Result of FASTA (omim) for
pFN21AB3827
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3827, 1168 aa
1>>>pF1KB3827 1168 - 1168 aa - 1168 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.5368+/-0.000397; mu= 17.8950+/- 0.025
mean_var=123.7604+/-24.974, 0's: 0 Z-trim(116.2): 40 B-trim: 288 in 1/52
Lambda= 0.115288
statistics sampled from 27074 (27114) to 27074 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.66), E-opt: 0.2 (0.318), width: 16
Scan time: 14.720
The best scores are: opt bits E(85289)
NP_443150 (OMIM: 606283) VPS10 domain-containing r (1168) 7858 1319.2 0
NP_001193500 (OMIM: 606283) VPS10 domain-containin (1159) 7586 1273.9 0
NP_001193501 (OMIM: 606283) VPS10 domain-containin (1179) 7568 1271.0 0
NP_001193498 (OMIM: 606283) VPS10 domain-containin (1179) 7568 1271.0 0
XP_011537501 (OMIM: 606283) PREDICTED: VPS10 domai (1187) 7568 1271.0 0
NP_001013049 (OMIM: 606283) VPS10 domain-containin (1198) 7568 1271.0 0
XP_016871103 (OMIM: 606283) PREDICTED: VPS10 domai (1203) 7568 1271.0 0
NP_001193499 (OMIM: 606283) VPS10 domain-containin (1130) 7564 1270.3 0
XP_011537503 (OMIM: 606283) PREDICTED: VPS10 domai (1116) 7337 1232.5 0
XP_016871104 (OMIM: 606283) PREDICTED: VPS10 domai (1159) 6840 1149.9 0
XP_016871105 (OMIM: 606283) PREDICTED: VPS10 domai (1031) 6306 1061.0 0
XP_016871106 (OMIM: 606283) PREDICTED: VPS10 domai (1018) 6304 1060.7 0
NP_055793 (OMIM: 606285) VPS10 domain-containing r (1222) 5064 854.5 0
XP_016871107 (OMIM: 606283) PREDICTED: VPS10 domai ( 726) 4351 735.7 2.4e-211
XP_011537844 (OMIM: 606285) PREDICTED: VPS10 domai ( 866) 3966 671.7 5.2e-192
NP_065828 (OMIM: 606284) VPS10 domain-containing r (1159) 3301 561.2 1.3e-158
XP_011511816 (OMIM: 606284) PREDICTED: VPS10 domai (1173) 3301 561.3 1.3e-158
XP_011511818 (OMIM: 606284) PREDICTED: VPS10 domai (1160) 3297 560.6 2e-158
XP_016863970 (OMIM: 606284) PREDICTED: VPS10 domai (1166) 3297 560.6 2.1e-158
XP_011511817 (OMIM: 606284) PREDICTED: VPS10 domai (1173) 3297 560.6 2.1e-158
XP_005248044 (OMIM: 606284) PREDICTED: VPS10 domai (1174) 3297 560.6 2.1e-158
XP_005271157 (OMIM: 602458,613589) PREDICTED: sort ( 830) 808 146.5 6.6e-34
NP_002950 (OMIM: 602458,613589) sortilin isoform 1 ( 831) 801 145.3 1.5e-33
NP_001192157 (OMIM: 602458,613589) sortilin isofor ( 694) 755 137.6 2.6e-31
XP_006710875 (OMIM: 602458,613589) PREDICTED: sort ( 695) 748 136.4 5.9e-31
XP_005271158 (OMIM: 602458,613589) PREDICTED: sort ( 695) 748 136.4 5.9e-31
XP_005271159 (OMIM: 602458,613589) PREDICTED: sort ( 695) 748 136.4 5.9e-31
XP_016873660 (OMIM: 104300,602005) PREDICTED: sort (1769) 652 120.8 7.6e-26
XP_016873659 (OMIM: 104300,602005) PREDICTED: sort (2039) 652 120.9 8.5e-26
XP_016873658 (OMIM: 104300,602005) PREDICTED: sort (2110) 652 120.9 8.7e-26
XP_011541265 (OMIM: 104300,602005) PREDICTED: sort (2176) 652 120.9 8.9e-26
NP_003096 (OMIM: 104300,602005) sortilin-related r (2214) 652 120.9 9e-26
XP_011541267 (OMIM: 104300,602005) PREDICTED: sort (1701) 380 75.5 3.1e-12
>>NP_443150 (OMIM: 606283) VPS10 domain-containing recep (1168 aa)
initn: 7858 init1: 7858 opt: 7858 Z-score: 7064.9 bits: 1319.2 E(85289): 0
Smith-Waterman score: 7858; 100.0% identity (100.0% similar) in 1168 aa overlap (1-1168:1-1168)
10 20 30 40 50 60
pF1KB3 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB3 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB3 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB3 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB3 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB3 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB3 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVALPSPPSPSTQPGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_443 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVALPSPPSPSTQPGD
1090 1100 1110 1120 1130 1140
1150 1160
pF1KB3 SSLRLQRARHATPPSTPKRGSAGAQYAI
::::::::::::::::::::::::::::
NP_443 SSLRLQRARHATPPSTPKRGSAGAQYAI
1150 1160
>>NP_001193500 (OMIM: 606283) VPS10 domain-containing re (1159 aa)
initn: 7568 init1: 7568 opt: 7586 Z-score: 6820.4 bits: 1273.9 E(85289): 0
Smith-Waterman score: 7586; 99.5% identity (99.6% similar) in 1135 aa overlap (1-1134:1-1135)
10 20 30 40 50 60
pF1KB3 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB3 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB3 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB3 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB3 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB3 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130
pF1KB3 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVAL-PSPPSPSTQPG
:::::::::::::::::::::::::::::::::::::::::::: :.: : :.:
NP_001 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRCVSLYPRSPTPDLFLL
1090 1100 1110 1120 1130 1140
1140 1150 1160
pF1KB3 DSSLRLQRARHATPPSTPKRGSAGAQYAI
NP_001 PDRFRSMCYSDVHSSDGFY
1150
>>NP_001193501 (OMIM: 606283) VPS10 domain-containing re (1179 aa)
initn: 7568 init1: 7568 opt: 7568 Z-score: 6804.1 bits: 1271.0 E(85289): 0
Smith-Waterman score: 7568; 99.8% identity (100.0% similar) in 1126 aa overlap (1-1126:1-1126)
10 20 30 40 50 60
pF1KB3 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB3 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB3 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB3 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB3 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB3 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB3 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVALPSPPSPSTQPGD
::::::::::::::::::::::::::::::::::::::::::::..
NP_001 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRKIPGINVYAQMQNEKE
1090 1100 1110 1120 1130 1140
1150 1160
pF1KB3 SSLRLQRARHATPPSTPKRGSAGAQYAI
NP_001 QEMISPVSHSESRPNVPQTELRRPGQLIDEKVESQLIGE
1150 1160 1170
>>NP_001193498 (OMIM: 606283) VPS10 domain-containing re (1179 aa)
initn: 7568 init1: 7568 opt: 7568 Z-score: 6804.1 bits: 1271.0 E(85289): 0
Smith-Waterman score: 7568; 99.8% identity (100.0% similar) in 1126 aa overlap (1-1126:1-1126)
10 20 30 40 50 60
pF1KB3 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB3 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB3 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB3 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB3 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB3 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB3 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVALPSPPSPSTQPGD
::::::::::::::::::::::::::::::::::::::::::::..
NP_001 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRKIPGINVYAQMQNEKE
1090 1100 1110 1120 1130 1140
1150 1160
pF1KB3 SSLRLQRARHATPPSTPKRGSAGAQYAI
NP_001 QEMISPVSHSESRPNVPQTELRRPGQLIDEKVESQLIGK
1150 1160 1170
>>XP_011537501 (OMIM: 606283) PREDICTED: VPS10 domain-co (1187 aa)
initn: 7568 init1: 7568 opt: 7568 Z-score: 6804.1 bits: 1271.0 E(85289): 0
Smith-Waterman score: 7568; 99.8% identity (100.0% similar) in 1126 aa overlap (1-1126:1-1126)
10 20 30 40 50 60
pF1KB3 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB3 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB3 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB3 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB3 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB3 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB3 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVALPSPPSPSTQPGD
::::::::::::::::::::::::::::::::::::::::::::..
XP_011 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRKIPGINVYAQMQNEKE
1090 1100 1110 1120 1130 1140
1150 1160
pF1KB3 SSLRLQRARHATPPSTPKRGSAGAQYAI
XP_011 QEMISPVSHSESRPNVPQTELRRPGQLIDEKVESQLIGRYRSTLQSL
1150 1160 1170 1180
>>NP_001013049 (OMIM: 606283) VPS10 domain-containing re (1198 aa)
initn: 7568 init1: 7568 opt: 7568 Z-score: 6804.0 bits: 1271.0 E(85289): 0
Smith-Waterman score: 7568; 99.8% identity (100.0% similar) in 1126 aa overlap (1-1126:1-1126)
10 20 30 40 50 60
pF1KB3 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB3 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB3 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB3 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB3 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB3 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB3 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVALPSPPSPSTQPGD
::::::::::::::::::::::::::::::::::::::::::::..
NP_001 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRKIPGINVYAQMQNEKE
1090 1100 1110 1120 1130 1140
1150 1160
pF1KB3 SSLRLQRARHATPPSTPKRGSAGAQYAI
NP_001 QEMISPVSHSESRPNVPQTELRRPGQLIDEKVESQLIGSISIVAENQSTKEIPTYVNV
1150 1160 1170 1180 1190
>>XP_016871103 (OMIM: 606283) PREDICTED: VPS10 domain-co (1203 aa)
initn: 7568 init1: 7568 opt: 7568 Z-score: 6804.0 bits: 1271.0 E(85289): 0
Smith-Waterman score: 7568; 99.8% identity (100.0% similar) in 1126 aa overlap (1-1126:1-1126)
10 20 30 40 50 60
pF1KB3 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB3 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB3 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB3 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB3 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB3 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB3 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVALPSPPSPSTQPGD
::::::::::::::::::::::::::::::::::::::::::::..
XP_016 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRKIPGINVYAQMQNEKE
1090 1100 1110 1120 1130 1140
1150 1160
pF1KB3 SSLRLQRARHATPPSTPKRGSAGAQYAI
XP_016 QEMISPVSHSESRPNVPQTELRRPGQLIDEKVESQLIEVPNSNFESSGVLGSCSVFSRNP
1150 1160 1170 1180 1190 1200
>>NP_001193499 (OMIM: 606283) VPS10 domain-containing re (1130 aa)
initn: 7564 init1: 7564 opt: 7564 Z-score: 6800.8 bits: 1270.3 E(85289): 0
Smith-Waterman score: 7564; 99.9% identity (100.0% similar) in 1125 aa overlap (1-1125:1-1125)
10 20 30 40 50 60
pF1KB3 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB3 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB3 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB3 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB3 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB3 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB3 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVALPSPPSPSTQPGD
::::::::::::::::::::::::::::::::::::::::::::.
NP_001 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRKYFHSC
1090 1100 1110 1120 1130
1150 1160
pF1KB3 SSLRLQRARHATPPSTPKRGSAGAQYAI
>>XP_011537503 (OMIM: 606283) PREDICTED: VPS10 domain-co (1116 aa)
initn: 7337 init1: 7337 opt: 7337 Z-score: 6596.8 bits: 1232.5 E(85289): 0
Smith-Waterman score: 7337; 100.0% identity (100.0% similar) in 1088 aa overlap (1-1088:1-1088)
10 20 30 40 50 60
pF1KB3 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB3 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB3 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB3 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB3 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KB3 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KB3 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVALPSPPSPSTQPGD
::::::::
XP_011 VHAAHLTAGVIKRCYHRDIRELIFPGFSCYHWMCYE
1090 1100 1110
>>XP_016871104 (OMIM: 606283) PREDICTED: VPS10 domain-co (1159 aa)
initn: 7264 init1: 6840 opt: 6840 Z-score: 6149.8 bits: 1149.9 E(85289): 0
Smith-Waterman score: 7179; 95.9% identity (96.1% similar) in 1126 aa overlap (1-1126:1-1082)
10 20 30 40 50 60
pF1KB3 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGKVGAGGGSQARLSALLAGAGLLILCAPGVCGGGSCCPSPHPSSAPRSASTPRGFSHQG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPGRAPATPLPLVVRPLFSVAPGDRALSLERARGTGASMAVAARSGRRRRSGADQEKAER
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GEGASRSPRGVLRDGGQQEPGTRERDPDKATRFRMEELRLTSTTFALTGDSAHNQAMVHW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGLKTILSYLYVCPTNK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQEDWILAYSQDQKLYSSA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVDGHSHYLTCRMQNCTEANRNQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFPGYIDPDSLIVQDHYVFVQLTSGGRPHYYVSYRRNAFAQMKLPKYALPKDMHVISTDE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NQVFAAVQEWNQNDTYNLYISDTRGVYFTLALENVQSSRGPEGNIMIDLYEVAGIKGMFL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ANKKIDNQVKTFITYNKGRDWRLLQAPDTDLRGDPVHCLLPYCSLHLHLKVSENPYTSGI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IASKDTAPSIIVASGNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAM
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KHTSLPIRHLWLSFDEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFGHFSHRSEWQL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKVDYKSIFDRRCAEEDYRPWQLHSQGEACIMGAKRIYKKRKSERKCMQGKYAGAMESEP
670 680 690 700 710 720
730 740 750 760 770 780
pF1KB3 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CVCTEADFDCDYGYERHSNGQCLPAFWFNPSSLSKDCSLGQSYLNSTGYRKVVSNNCTDG
730 740 750 760 770 780
790 800 810 820 830 840
pF1KB3 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VREQYTAKPQKCPGKAPRGLRIVTADGKLTAEQGHNVTLMVQLEEGDVQRTLIQVDFGDG
790 800 810 820 830 840
850 860 870 880 890 900
pF1KB3 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IAVSYVNLSSMEDGIKHVYQNVGIFRVTVQVDNSLGSDSAVLYLHVTCPLEHVHLSLPFV
850 860 870 880 890 900
910 920 930 940 950 960
pF1KB3 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTKNKEVNATAVLWPSQVGTLTYVWWYGNNTEPLITLEGSISFRFTSEGMNTITVQVSAG
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KB3 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVEATGVPGQHI
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NAILQDTKTIAVYEEFRSLRLSFSPNLDDYNPDIPEWRRDIGRVIKKSLVE---------
970 980 990 1000 1010
1030 1040 1050 1060 1070 1080
pF1KB3 LVAVLPGLPTTAELFVLPYQDPAGENKRSTDDLEQISELLIHTLNQNSVHFELKPGVRVL
:::::::::::::::::::::::::
XP_016 -----------------------------------ISELLIHTLNQNSVHFELKPGVRVL
1020 1030
1090 1100 1110 1120 1130 1140
pF1KB3 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRRVALPSPPSPSTQPGD
::::::::::::::::::::::::::::::::::::::::::::..
XP_016 VHAAHLTAAPLVDLTPTHSGSAMLMLLSVVFVGLAVFVIYKFKRKIPGINVYAQMQNEKE
1040 1050 1060 1070 1080 1090
1150 1160
pF1KB3 SSLRLQRARHATPPSTPKRGSAGAQYAI
XP_016 QEMISPVSHSESRPNVPQTELRRPGQLIDEKVESQLIEVPNSNFESSGVLGSCSVFSRNP
1100 1110 1120 1130 1140 1150
1168 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 14:01:49 2016 done: Thu Nov 3 14:01:51 2016
Total Scan time: 14.720 Total Display time: 0.530
Function used was FASTA [36.3.4 Apr, 2011]