Result of FASTA (omim) for
pFN21AB3796
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3796, 860 aa
1>>>pF1KB3796 860 - 860 aa - 860 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.9615+/-0.000474; mu= -1.1107+/- 0.029
mean_var=279.7903+/-56.180, 0's: 0 Z-trim(118.7): 202 B-trim: 115 in 1/53
Lambda= 0.076676
statistics sampled from 31789 (32008) to 31789 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.711), E-opt: 0.2 (0.375), width: 16
Scan time: 13.430
The best scores are: opt bits E(85289)
XP_016872194 (OMIM: 602714) PREDICTED: disintegrin ( 753) 4781 543.2 1.6e-153
NP_001275902 (OMIM: 602714) disintegrin and metall ( 906) 4781 543.3 1.9e-153
NP_003465 (OMIM: 602714) disintegrin and metallopr ( 909) 4781 543.3 1.9e-153
XP_016872195 (OMIM: 602714) PREDICTED: disintegrin ( 520) 3801 434.7 5.2e-121
NP_001275904 (OMIM: 602714) disintegrin and metall ( 735) 3349 384.8 7.7e-106
NP_067673 (OMIM: 602714) disintegrin and metallopr ( 738) 3349 384.8 7.7e-106
NP_001275903 (OMIM: 602714) disintegrin and metall ( 737) 3348 384.7 8.3e-106
NP_150377 (OMIM: 603640) disintegrin and metallopr ( 918) 2087 245.3 9.6e-64
XP_005266060 (OMIM: 603640) PREDICTED: disintegrin ( 955) 2087 245.3 9.9e-64
XP_011532984 (OMIM: 603640) PREDICTED: disintegrin ( 651) 1992 234.7 1.1e-60
XP_016865498 (OMIM: 603640) PREDICTED: disintegrin ( 651) 1992 234.7 1.1e-60
XP_011527669 (OMIM: 607114) PREDICTED: disintegrin ( 812) 1750 208.0 1.5e-52
NP_079496 (OMIM: 607114) disintegrin and metallopr ( 813) 1750 208.0 1.5e-52
XP_011527668 (OMIM: 607114) PREDICTED: disintegrin ( 825) 1750 208.0 1.5e-52
XP_005260900 (OMIM: 607114) PREDICTED: disintegrin ( 826) 1750 208.0 1.5e-52
NP_001269376 (OMIM: 607114) disintegrin and metall ( 812) 1745 207.4 2.1e-52
XP_006723702 (OMIM: 607114) PREDICTED: disintegrin ( 825) 1745 207.4 2.2e-52
XP_006723703 (OMIM: 607114) PREDICTED: disintegrin ( 823) 1733 206.1 5.4e-52
NP_997079 (OMIM: 605548) disintegrin and metallopr ( 862) 1595 190.9 2.2e-47
NP_997080 (OMIM: 605548) disintegrin and metallopr ( 863) 1595 190.9 2.2e-47
NP_997077 (OMIM: 605548) disintegrin and metallopr ( 839) 1571 188.2 1.4e-46
NP_997078 (OMIM: 605548) disintegrin and metallopr ( 838) 1568 187.9 1.7e-46
NP_997074 (OMIM: 605548) disintegrin and metallopr ( 772) 1542 185.0 1.2e-45
NP_001248394 (OMIM: 605548) disintegrin and metall ( 796) 1542 185.0 1.2e-45
NP_003806 (OMIM: 605548) disintegrin and metallopr ( 814) 1542 185.0 1.2e-45
NP_001248393 (OMIM: 605548) disintegrin and metall ( 824) 1542 185.0 1.2e-45
XP_011542984 (OMIM: 602713,612775) PREDICTED: disi ( 801) 1521 182.6 6.1e-45
NP_003807 (OMIM: 602713,612775) disintegrin and me ( 819) 1521 182.7 6.2e-45
XP_016869431 (OMIM: 602713,612775) PREDICTED: disi ( 821) 1521 182.7 6.2e-45
XP_011527675 (OMIM: 607114) PREDICTED: disintegrin ( 492) 1509 181.2 1.1e-44
NP_694882 (OMIM: 607114) disintegrin and metallopr ( 787) 1451 174.9 1.3e-42
XP_011527670 (OMIM: 607114) PREDICTED: disintegrin ( 800) 1451 174.9 1.3e-42
NP_001248395 (OMIM: 605548) disintegrin and metall ( 633) 1331 161.6 1.1e-38
NP_001157961 (OMIM: 602267) disintegrin and metall ( 742) 1186 145.6 8.2e-34
XP_016870955 (OMIM: 602267) PREDICTED: disintegrin ( 779) 1186 145.6 8.6e-34
NP_001100 (OMIM: 602267) disintegrin and metallopr ( 824) 1186 145.6 8.9e-34
XP_011537419 (OMIM: 602267) PREDICTED: disintegrin ( 863) 1186 145.6 9.3e-34
XP_016870954 (OMIM: 602267) PREDICTED: disintegrin ( 889) 1186 145.6 9.5e-34
NP_001157962 (OMIM: 602267) disintegrin and metall ( 733) 1174 144.2 2.1e-33
XP_011527672 (OMIM: 607114) PREDICTED: disintegrin ( 635) 1159 142.5 5.8e-33
NP_003808 (OMIM: 607310) disintegrin and metallopr ( 754) 1130 139.4 6.1e-32
XP_016869432 (OMIM: 607310) PREDICTED: disintegrin ( 755) 1130 139.4 6.1e-32
XP_016867825 (OMIM: 603709) PREDICTED: disintegrin ( 907) 1124 138.8 1.1e-31
XP_016867823 (OMIM: 603709) PREDICTED: disintegrin ( 924) 1124 138.8 1.1e-31
NP_068367 (OMIM: 603709) disintegrin and metallopr ( 823) 1119 138.2 1.5e-31
NP_004185 (OMIM: 603709) disintegrin and metallopr ( 859) 1119 138.2 1.6e-31
NP_001311346 (OMIM: 603709) disintegrin and metall ( 869) 1119 138.2 1.6e-31
NP_057435 (OMIM: 603709) disintegrin and metallopr ( 870) 1119 138.2 1.6e-31
XP_016867828 (OMIM: 603709) PREDICTED: disintegrin ( 887) 1119 138.2 1.6e-31
NP_001311350 (OMIM: 603709) disintegrin and metall ( 890) 1119 138.2 1.6e-31
>>XP_016872194 (OMIM: 602714) PREDICTED: disintegrin and (753 aa)
initn: 4781 init1: 4781 opt: 4781 Z-score: 2877.1 bits: 543.2 E(85289): 1.6e-153
Smith-Waterman score: 5010; 93.9% identity (93.9% similar) in 753 aa overlap (154-860:1-753)
130 140 150 160 170 180
pF1KB3 GYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCGSHHNTP
::::::::::::::::::::::::::::::
XP_016 MKSATNRYKLFPAKKLKSVRGSCGSHHNTP
10 20 30
190 200
pF1KB3 NLAAKNVFPPPSQTWARR------------------------------------------
::::::::::::::::::
XP_016 NLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIEIAN
40 50 60 70 80 90
210 220 230 240 250
pF1KB3 ----FYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNAQLV
100 110 120 130 140 150
260 270 280 290 300 310
pF1KB3 SGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTLDRG
160 170 180 190 200 210
320 330 340 350 360 370
pF1KB3 CSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFGGQK
220 230 240 250 260 270
380 390 400 410 420 430
pF1KB3 CGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACRDSS
280 290 300 310 320 330
440 450 460 470 480 490
pF1KB3 NSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKPAPG
340 350 360 370 380 390
500 510 520 530 540 550
pF1KB3 ICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIETNIP
400 410 420 430 440 450
560 570 580 590 600 610
pF1KB3 LQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQCHG
460 470 480 490 500 510
620 630 640 650 660 670
pF1KB3 RGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILVTILCLLAAGFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILVTILCLLAAGFV
520 530 540 550 560 570
680 690 700 710 720 730
pF1KB3 VYLKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPPDSYPPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VYLKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPPDSYPPK
580 590 600 610 620 630
740 750 760 770 780 790
pF1KB3 DNPRRLLQCQNVDISRPLNGLNVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKPALRQAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DNPRRLLQCQNVDISRPLNGLNVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKPALRQAQ
640 650 660 670 680 690
800 810 820 830 840 850
pF1KB3 GTCKPNPPQKPLPADPLARTTRLTHALARTPGQWETGLRLAPLRPAPQYPHQVPRSTHTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GTCKPNPPQKPLPADPLARTTRLTHALARTPGQWETGLRLAPLRPAPQYPHQVPRSTHTA
700 710 720 730 740 750
860
pF1KB3 YIK
:::
XP_016 YIK
>>NP_001275902 (OMIM: 602714) disintegrin and metallopro (906 aa)
initn: 4781 init1: 4781 opt: 4781 Z-score: 2876.0 bits: 543.3 E(85289): 1.9e-153
Smith-Waterman score: 5914; 94.7% identity (94.7% similar) in 892 aa overlap (15-860:15-906)
10 20 30 40 50 60
pF1KB3 MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVRSGDLWIPVKSFD
::::::::::::::::::::::::::::::::: ::::::::::::
NP_001 MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 SKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTGHCYYHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTGHCYYHG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 HVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCGSHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCGSHH
130 140 150 160 170 180
190 200
pF1KB3 NTPNLAAKNVFPPPSQTWARR---------------------------------------
:::::::::::::::::::::
NP_001 NTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIE
190 200 210 220 230 240
210 220 230 240 250
pF1KB3 -------FYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNA
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNA
250 260 270 280 290 300
260 270 280 290 300 310
pF1KB3 QLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTL
310 320 330 340 350 360
320 330 340 350 360 370
pF1KB3 DRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFG
370 380 390 400 410 420
380 390 400 410 420 430
pF1KB3 GQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACR
430 440 450 460 470 480
440 450 460 470 480 490
pF1KB3 DSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKP
490 500 510 520 530 540
500 510 520 530 540 550
pF1KB3 APGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIET
550 560 570 580 590 600
560 570 580 590 600 610
pF1KB3 NIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQ
610 620 630 640 650 660
620 630 640 650 660 670
pF1KB3 CHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILVTILCLLAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILVTILCLLAA
670 680 690 700 710 720
680 690 700 710 720 730
pF1KB3 GFVVYLKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPPDSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFVVYLKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPPDSY
730 740 750 760 770 780
740 750 760 770 780 790
pF1KB3 PPKDNPRRLLQCQNVDISRPLNGLNVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKPALR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPKDNPRRLLQCQNVDISRPLNGLNVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKPALR
790 800 810 820 830 840
800 810 820 830 840 850
pF1KB3 QAQGTCKPNPPQKPLPADPLARTTRLTHALARTPGQWETGLRLAPLRPAPQYPHQVPRST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QAQGTCKPNPPQKPLPADPLARTTRLTHALARTPGQWETGLRLAPLRPAPQYPHQVPRST
850 860 870 880 890 900
860
pF1KB3 HTAYIK
::::::
NP_001 HTAYIK
>>NP_003465 (OMIM: 602714) disintegrin and metalloprotei (909 aa)
initn: 5484 init1: 4781 opt: 4781 Z-score: 2876.0 bits: 543.3 E(85289): 1.9e-153
Smith-Waterman score: 5883; 94.4% identity (94.4% similar) in 892 aa overlap (18-860:18-909)
10 20 30 40 50 60
pF1KB3 MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVRSGDLWIPVKSFD
:::::::::::::::::::::::::::::: ::::::::::::
NP_003 MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFD
10 20 30 40 50 60
70 80 90 100 110
pF1KB3 SKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYT---GHCY
::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
NP_003 SKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCY
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB3 YHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 YHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCG
130 140 150 160 170 180
180 190 200
pF1KB3 SHHNTPNLAAKNVFPPPSQTWARR------------------------------------
::::::::::::::::::::::::
NP_003 SHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQR
190 200 210 220 230 240
210 220 230 240 250
pF1KB3 ----------FYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSH
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSH
250 260 270 280 290 300
260 270 280 290 300 310
pF1KB3 DNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNH
310 320 330 340 350 360
320 330 340 350 360 370
pF1KB3 DTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRE
370 380 390 400 410 420
380 390 400 410 420 430
pF1KB3 SFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGT
430 440 450 460 470 480
440 450 460 470 480 490
pF1KB3 ACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPG
490 500 510 520 530 540
500 510 520 530 540 550
pF1KB3 AKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 AKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVS
550 560 570 580 590 600
560 570 580 590 600 610
pF1KB3 IETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 IETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHEC
610 620 630 640 650 660
620 630 640 650 660 670
pF1KB3 AMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILVTILCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 AMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILVTILCL
670 680 690 700 710 720
680 690 700 710 720 730
pF1KB3 LAAGFVVYLKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 LAAGFVVYLKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPP
730 740 750 760 770 780
740 750 760 770 780 790
pF1KB3 DSYPPKDNPRRLLQCQNVDISRPLNGLNVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DSYPPKDNPRRLLQCQNVDISRPLNGLNVPQPQSTQRVLPPLHRAPRAPSVPARPLPAKP
790 800 810 820 830 840
800 810 820 830 840 850
pF1KB3 ALRQAQGTCKPNPPQKPLPADPLARTTRLTHALARTPGQWETGLRLAPLRPAPQYPHQVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 ALRQAQGTCKPNPPQKPLPADPLARTTRLTHALARTPGQWETGLRLAPLRPAPQYPHQVP
850 860 870 880 890 900
860
pF1KB3 RSTHTAYIK
:::::::::
NP_003 RSTHTAYIK
>>XP_016872195 (OMIM: 602714) PREDICTED: disintegrin and (520 aa)
initn: 3801 init1: 3801 opt: 3801 Z-score: 2293.4 bits: 434.7 E(85289): 5.2e-121
Smith-Waterman score: 3801; 100.0% identity (100.0% similar) in 520 aa overlap (341-860:1-520)
320 330 340 350 360 370
pF1KB3 HDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVR
::::::::::::::::::::::::::::::
XP_016 MVFSSCSRKDLETSLEKGMGVCLFNLPEVR
10 20 30
380 390 400 410 420 430
pF1KB3 ESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAG
40 50 60 70 80 90
440 450 460 470 480 490
pF1KB3 TACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGP
100 110 120 130 140 150
500 510 520 530 540 550
pF1KB3 GAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAV
160 170 180 190 200 210
560 570 580 590 600 610
pF1KB3 SIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SIETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHE
220 230 240 250 260 270
620 630 640 650 660 670
pF1KB3 CAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILVTILC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILVTILC
280 290 300 310 320 330
680 690 700 710 720 730
pF1KB3 LLAAGFVVYLKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLAAGFVVYLKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKP
340 350 360 370 380 390
740 750 760 770 780 790
pF1KB3 PDSYPPKDNPRRLLQCQNVDISRPLNGLNVPQPQSTQRVLPPLHRAPRAPSVPARPLPAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PDSYPPKDNPRRLLQCQNVDISRPLNGLNVPQPQSTQRVLPPLHRAPRAPSVPARPLPAK
400 410 420 430 440 450
800 810 820 830 840 850
pF1KB3 PALRQAQGTCKPNPPQKPLPADPLARTTRLTHALARTPGQWETGLRLAPLRPAPQYPHQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PALRQAQGTCKPNPPQKPLPADPLARTTRLTHALARTPGQWETGLRLAPLRPAPQYPHQV
460 470 480 490 500 510
860
pF1KB3 PRSTHTAYIK
::::::::::
XP_016 PRSTHTAYIK
520
>>NP_001275904 (OMIM: 602714) disintegrin and metallopro (735 aa)
initn: 4665 init1: 3346 opt: 3349 Z-score: 2021.2 bits: 384.8 E(85289): 7.7e-106
Smith-Waterman score: 4482; 93.0% identity (93.2% similar) in 688 aa overlap (15-656:15-702)
10 20 30 40 50 60
pF1KB3 MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVRSGDLWIPVKSFD
::::::::::::::::::::::::::::::::: ::::::::::::
NP_001 MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 SKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTGHCYYHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTGHCYYHG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 HVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCGSHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCGSHH
130 140 150 160 170 180
190 200
pF1KB3 NTPNLAAKNVFPPPSQTWARR---------------------------------------
:::::::::::::::::::::
NP_001 NTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIE
190 200 210 220 230 240
210 220 230 240 250
pF1KB3 -------FYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNA
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNA
250 260 270 280 290 300
260 270 280 290 300 310
pF1KB3 QLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTL
310 320 330 340 350 360
320 330 340 350 360 370
pF1KB3 DRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFG
370 380 390 400 410 420
380 390 400 410 420 430
pF1KB3 GQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACR
430 440 450 460 470 480
440 450 460 470 480 490
pF1KB3 DSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKP
490 500 510 520 530 540
500 510 520 530 540 550
pF1KB3 APGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIET
550 560 570 580 590 600
560 570 580 590 600 610
pF1KB3 NIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQ
610 620 630 640 650 660
620 630 640 650 660 670
pF1KB3 CHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILVTILCLLAA
:::::::::::::::::::::::::::::::::::::::::.
NP_001 CHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQAEARQEAAESNRERGQGQEP
670 680 690 700 710 720
680 690 700 710 720 730
pF1KB3 GFVVYLKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPPDSY
NP_001 VGSQEHASTASLTLI
730
>>NP_067673 (OMIM: 602714) disintegrin and metalloprotei (738 aa)
initn: 4651 init1: 3346 opt: 3349 Z-score: 2021.1 bits: 384.8 E(85289): 7.7e-106
Smith-Waterman score: 4451; 92.6% identity (92.7% similar) in 688 aa overlap (18-656:18-705)
10 20 30 40 50 60
pF1KB3 MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVRSGDLWIPVKSFD
:::::::::::::::::::::::::::::: ::::::::::::
NP_067 MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFD
10 20 30 40 50 60
70 80 90 100 110
pF1KB3 SKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYT---GHCY
::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
NP_067 SKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTVILGHCY
70 80 90 100 110 120
120 130 140 150 160 170
pF1KB3 YHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 YHGHVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCG
130 140 150 160 170 180
180 190 200
pF1KB3 SHHNTPNLAAKNVFPPPSQTWARR------------------------------------
::::::::::::::::::::::::
NP_067 SHHNTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQR
190 200 210 220 230 240
210 220 230 240 250
pF1KB3 ----------FYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSH
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 LIEIANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSH
250 260 270 280 290 300
260 270 280 290 300 310
pF1KB3 DNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 DNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNH
310 320 330 340 350 360
320 330 340 350 360 370
pF1KB3 DTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 DTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRE
370 380 390 400 410 420
380 390 400 410 420 430
pF1KB3 SFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 SFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGT
430 440 450 460 470 480
440 450 460 470 480 490
pF1KB3 ACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 ACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPG
490 500 510 520 530 540
500 510 520 530 540 550
pF1KB3 AKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 AKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVS
550 560 570 580 590 600
560 570 580 590 600 610
pF1KB3 IETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_067 IETNIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHEC
610 620 630 640 650 660
620 630 640 650 660 670
pF1KB3 AMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILVTILCL
::::::::::::::::::::::::::::::::::::::::::::.
NP_067 AMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQAEARQEAAESNRERGQG
670 680 690 700 710 720
680 690 700 710 720 730
pF1KB3 LAAGFVVYLKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPP
NP_067 QEPVGSQEHASTASLTLI
730
>>NP_001275903 (OMIM: 602714) disintegrin and metallopro (737 aa)
initn: 4664 init1: 3345 opt: 3348 Z-score: 2020.5 bits: 384.7 E(85289): 8.3e-106
Smith-Waterman score: 4481; 92.8% identity (93.0% similar) in 690 aa overlap (15-658:15-704)
10 20 30 40 50 60
pF1KB3 MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVRSGDLWIPVKSFD
::::::::::::::::::::::::::::::::: ::::::::::::
NP_001 MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVGSGDLWIPVKSFD
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 SKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTGHCYYHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTGHCYYHG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 HVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCGSHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HVRGYSDSAVSLSTCSGLRGLIVFENESYVLEPMKSATNRYKLFPAKKLKSVRGSCGSHH
130 140 150 160 170 180
190 200
pF1KB3 NTPNLAAKNVFPPPSQTWARR---------------------------------------
:::::::::::::::::::::
NP_001 NTPNLAAKNVFPPPSQTWARRHKRETLKATKYVELVIVADNREFQRQGKDLEKVKQRLIE
190 200 210 220 230 240
210 220 230 240 250
pF1KB3 -------FYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNA
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IANHVDKFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDNA
250 260 270 280 290 300
260 270 280 290 300 310
pF1KB3 QLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDTL
310 320 330 340 350 360
320 330 340 350 360 370
pF1KB3 DRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESFG
370 380 390 400 410 420
380 390 400 410 420 430
pF1KB3 GQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTACR
430 440 450 460 470 480
440 450 460 470 480 490
pF1KB3 DSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAKP
490 500 510 520 530 540
500 510 520 530 540 550
pF1KB3 APGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIET
550 560 570 580 590 600
560 570 580 590 600 610
pF1KB3 NIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NIPLQQGGRILCRGTHVYLGDDMPDPGLVLAGTKCADGKICLNRQCQNISVFGVHECAMQ
610 620 630 640 650 660
620 630 640 650 660 670
pF1KB3 CHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILVTILCLLAA
::::::::::::::::::::::::::::::::::::::::: ..
NP_001 CHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQAGKEARQEAAESNRERGQGQ
670 680 690 700 710 720
680 690 700 710 720 730
pF1KB3 GFVVYLKRKTLIRLLFTNKKTTIEKLRCVRPSRPPRGFQPCQAHLGHLGKGLMRKPPDSY
NP_001 EPVGSQEHASTASLTLI
730
>>NP_150377 (OMIM: 603640) disintegrin and metalloprotei (918 aa)
initn: 2260 init1: 1077 opt: 2087 Z-score: 1265.4 bits: 245.3 E(85289): 9.6e-64
Smith-Waterman score: 2415; 43.0% identity (64.4% similar) in 915 aa overlap (15-849:12-908)
10 20 30 40 50
pF1KB3 MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVRSGDLWIPV-KSF
:::.: : : :: . :..: .: : ... .: :: :.
NP_150 MPGGAGAARLCLLAFALQPLRPRAAREPG-WTRG--SEEGSPKLQH-ELIIPQWKTS
10 20 30 40 50
60 70 80 90 100 110
pF1KB3 DS---KNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTGHC
.: ..:: ..:.. :..:::..::.:: :.: :.::::: ..:. . .:. ::
NP_150 ESPVREKHPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHC
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB3 YYHGHVRGYSDSAVSLSTCSGLRGLI-VFENESYVLEPMKSATNRYKLFPAKKLKSVRGS
.::: :: :.:.:::: :.:::: : : :::.::. .. ... .. ...:: :.
NP_150 FYHGTVRETELSSVTLSTCRGIRGLITVSSNLSYVIEPLPDSKGQHLIYRSEHLKPPPGN
120 130 140 150 160 170
180 190 200
pF1KB3 CGSHHNTPNLAAKNV-FPPPSQTWARR---------------------------------
:: .:. :. . : .. ::
NP_150 CGFEHSKPTTRDWALQFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDAT
180 190 200 210 220 230
210 220 230 240
pF1KB3 -------------FYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPR
::: :::::.:::.:::. . : ::..:...: ::.::. ::: .
NP_150 KHKLIEIANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRR-KLLAQ
240 250 260 270 280 290
250 260 270 280 290 300
pF1KB3 KSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFG
: ::::::..:. :.:::::.::.:.::.. ::::. ::::.: .:.:.:.:::.:::::
NP_150 KYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFG
300 310 320 330 340 350
310 320 330 340 350 360
pF1KB3 MNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPE
:.::. : : :. .. ::::: :.::.::: ::..:.:..:. :..: :.:: :.:.
NP_150 MTHDSAD--C-CSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPD
360 370 380 390 400
370 380 390 400 410 420
pF1KB3 VRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKP
.: .::..::: ..:.:::::::: ::: : ::::..:::.: : :::: ::..:.:
NP_150 TRMLYGGRRCGNGYLEDGEECDCGEEEECNNPCCNASNCTLRPGAECAHGSCCHQCKLLA
410 420 430 440 450 460
430 440 450 460 470 480
pF1KB3 AGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLW
:: ::... .::::::::: :::::.: : :: :. ..:::::.: :...:: ::
NP_150 PGTLCREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLW
470 480 490 500 510 520
490 500 510 520 530 540
pF1KB3 GPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTN
::::.::: .:::.:: ::: .::::: .. ::.::::::::::::.. .:: . .:
NP_150 GPGARPAPDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARP-LESN
530 540 550 560 570 580
550 560 570 580 590 600
pF1KB3 AVSIETNIPLQQGGRILCRGTHVYLGD----DMPDPGLVLAGTKCADGKICLNRQCQNIS
:: :.:.: ...: .: ::::::: : :: :::::..::::. ..::.. ::.: :
NP_150 AVPIDTTI-IMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTS
590 600 610 620 630 640
610 620 630 640 650 660
pF1KB3 VFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGI
: .. :. .:.:.::::: .:::: ::::::. : ::: ::::. . .. :.
NP_150 FFETEGCGKKCNGHGVCNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGV
650 660 670 680 690 700
670 680 690 700 710
pF1KB3 LVTILCLLAAGFVVYLKRKTLIRLLFTNKKTTIEKLR----C-VRPSR--------PPRG
::.:: : . .. : :.. .: . .. ::: : : :. :
NP_150 LVAILVLAVLMLMYYCCRQN-NKLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFK
710 720 730 740 750 760
720 730 740 750 760
pF1KB3 FQPCQAHLGHLGKG-LMRKPPDSYPPKDNPRRLLQCQNVDISRPLN----GLNVPQPQST
.: :.. .. ..::: : :: : :. . : . . : : : :
NP_150 LQTPQGKRKVINTPEILRKP--SQPPPRPPPDYLRGGSPPAPLPAHLSRAARNSPGPGSQ
770 780 790 800 810 820
770 780 790 800 810 820
pF1KB3 QRVLPPLHRAPRAPSVPARPLPAKPALRQAQGTCKPNPPQKPLPADPLARTTRLTHALA-
. .: : :.::.: : .: .: :::: :::.:. : . .
NP_150 IERTESSRRPP-----PSRPIPPAPNCIVSQDFSRPRPPQKALPANPVPGRRSLPRPGGA
830 840 850 860 870
830 840 850 860
pF1KB3 ---RTPGQWETGLR-LAPLRPA-PQYPHQVPRSTHTAYIK
: :: : :: : : :.: :
NP_150 SPLRPPGAGPQQSRPLAALAPKFPEYRSQRAGGMISSKI
880 890 900 910
>>XP_005266060 (OMIM: 603640) PREDICTED: disintegrin and (955 aa)
initn: 2273 init1: 1077 opt: 2087 Z-score: 1265.1 bits: 245.3 E(85289): 9.9e-64
Smith-Waterman score: 2414; 43.0% identity (64.6% similar) in 909 aa overlap (15-849:12-891)
10 20 30 40 50
pF1KB3 MAARPLPVSPARALLLALAGALLAPCEARGVSLWNQGRADEVVSASVRSGDLWIPV-KSF
:::.: : : :: . :..: .: : ... .: :: :.
XP_005 MPGGAGAARLCLLAFALQPLRPRAAREPG-WTRG--SEEGSPKLQH-ELIIPQWKTS
10 20 30 40 50
60 70 80 90 100 110
pF1KB3 DS---KNHPEVLNIRLQRESKELIINLERNEGLIASSFTETHYLQDGTDVSLARNYTGHC
.: ..:: ..:.. :..:::..::.:: :.: :.::::: ..:. . .:. ::
XP_005 ESPVREKHPLKAELRVMAEGRELILDLEKNEQLFAPSYTETHYTSSGNPQTTTRKLEDHC
60 70 80 90 100 110
120 130 140 150 160 170
pF1KB3 YYHGHVRGYSDSAVSLSTCSGLRGLI-VFENESYVLEPMKSATNRYKLFPAKKLKSVRGS
.::: :: :.:.:::: :.:::: : : :::.::. .. ... .. ...:: :.
XP_005 FYHGTVRETELSSVTLSTCRGIRGLITVSSNLSYVIEPLPDSKGQHLIYRSEHLKPPPGN
120 130 140 150 160 170
180 190 200
pF1KB3 CGSHHNTPNLAAKNV-FPPPSQTWARR---------------------------------
:: .:. :. . : .. ::
XP_005 CGFEHSKPTTRDWALQFTQQTKKRPRRMKREDLNSMKYVELYLVADYLEFQKNRRDQDAT
180 190 200 210 220 230
210 220 230 240
pF1KB3 -------------FYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPR
::: :::::.:::.:::. . : ::..:...: ::.::. ::: .
XP_005 KHKLIEIANYVDKFYRSLNIRIALVGLEVWTHGNMCEVSENPYSTLWSFLSWRR-KLLAQ
240 250 260 270 280 290
250 260 270 280 290 300
pF1KB3 KSHDNAQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFG
: ::::::..:. :.:::::.::.:.::.. ::::. ::::.: .:.:.:.:::.:::::
XP_005 KYHDNAQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFG
300 310 320 330 340 350
310 320 330 340 350 360
pF1KB3 MNHDTLDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPE
:.::. : : :. .. ::::: :.::.::: ::..:.:..:. :..: :.:: :.:.
XP_005 MTHDSAD--C-CSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPD
360 370 380 390 400
370 380 390 400 410 420
pF1KB3 VRESFGGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKP
.: .::..::: ..:.:::::::: ::: : ::::..:::.: : :::: ::..:.:
XP_005 TRMLYGGRRCGNGYLEDGEECDCGEEEECNNPCCNASNCTLRPGAECAHGSCCHQCKLLA
410 420 430 440 450 460
430 440 450 460 470 480
pF1KB3 AGTACRDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLW
:: ::... .::::::::: :::::.: : :: :. ..:::::.: :...:: ::
XP_005 PGTLCREQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLW
470 480 490 500 510 520
490 500 510 520 530 540
pF1KB3 GPGAKPAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTN
::::.::: .:::.:: ::: .::::: .. ::.::::::::::::.. .:: . .:
XP_005 GPGARPAPDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARP-LESN
530 540 550 560 570 580
550 560 570 580 590 600
pF1KB3 AVSIETNIPLQQGGRILCRGTHVYLGD----DMPDPGLVLAGTKCADGKICLNRQCQNIS
:: :.:.: ...: .: ::::::: : :: :::::..::::. ..::.. ::.: :
XP_005 AVPIDTTI-IMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTS
590 600 610 620 630 640
610 620 630 640 650 660
pF1KB3 VFGVHECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGI
: .. :. .:.:.::::: .:::: ::::::. : ::: ::::. . .. :.
XP_005 FFETEGCGKKCNGHGVCNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGV
650 660 670 680 690 700
670 680 690 700 710
pF1KB3 LVTILCLLAAGFVVYLKRKTLIRLLFTNKKTTIEKLR----C-VRPSR--------PPRG
::.:: : . .. : :.. .: . .. ::: : : :. :
XP_005 LVAILVLAVLMLMYYCCRQN-NKLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFK
710 720 730 740 750 760
720 730 740 750 760
pF1KB3 FQPCQAHLGHLGKG-LMRKPPDSYPPKDNPRRLLQCQNVDISRPLN----GLNVPQPQST
.: :.. .. ..::: : :: : :. . : . . : : : :
XP_005 LQTPQGKRKVINTPEILRKP--SQPPPRPPPDYLRGGSPPAPLPAHLSRAARNSPGPGSQ
770 780 790 800 810 820
770 780 790 800 810 820
pF1KB3 QRVLPPLHRAPRAPSVPARPLPAKPALRQAQGTCKPNPPQKPLPADPLARTTRLTHALAR
. .: : :.::.: : .: .: :::: :::.:. : .
XP_005 IERTESSRRPP-----PSRPIPPAPNCIVSQDFSRPRPPQKALPANPVPGRRSLPR----
830 840 850 860 870
830 840 850 860
pF1KB3 TPGQWETGLRLAPLRPAPQYPHQVPRSTHTAYIK
:: : .:::: :.:
XP_005 -PG----GA--SPLRPPGAGPQQSRPLAALAPKVSPREALKVKAGTRGLQGGRCRVEKTK
880 890 900 910 920
>>XP_011532984 (OMIM: 603640) PREDICTED: disintegrin and (651 aa)
initn: 1925 init1: 1077 opt: 1992 Z-score: 1210.6 bits: 234.7 E(85289): 1.1e-60
Smith-Waterman score: 2061; 46.8% identity (67.8% similar) in 652 aa overlap (224-849:2-641)
200 210 220 230 240 250
pF1KB3 PSQTWARRFYRPLNIRIVLVGVEVWNDMDKCSVSQDPFTSLHEFLDWRKMKLLPRKSHDN
: ::..:...: ::.::. ::: .: :::
XP_011 MCEVSENPYSTLWSFLSWRR-KLLAQKYHDN
10 20 30
260 270 280 290 300 310
pF1KB3 AQLVSGVYFQGTTIGMAPIMSMCTADQSGGIVMDHSDNPLGAAVTLAHELGHNFGMNHDT
:::..:. :.:::::.::.:.::.. ::::. ::::.: .:.:.:.:::.::::::.::.
XP_011 AQLITGMSFHGTTIGLAPLMAMCSVYQSGGVNMDHSENAIGVAATMAHEMGHNFGMTHDS
40 50 60 70 80 90
320 330 340 350 360 370
pF1KB3 LDRGCSCQMAVEKGGCIMNASTGYPFPMVFSSCSRKDLETSLEKGMGVCLFNLPEVRESF
: : :. .. ::::: :.::.::: ::..:.:..:. :..: :.:: :.:..: .
XP_011 AD--C-CSASAADGGCIMAAATGHPFPKVFNGCNRRELDRYLQSGGGMCLSNMPDTRMLY
100 110 120 130 140
380 390 400 410 420 430
pF1KB3 GGQKCGNRFVEEGEECDCGEPEECMNRCCNATTCTLKPDAVCAHGLCCEDCQLKPAGTAC
::..::: ..:.:::::::: ::: : ::::..:::.: : :::: ::..:.: :: :
XP_011 GGRRCGNGYLEDGEECDCGEEEECNNPCCNASNCTLRPGAECAHGSCCHQCKLLAPGTLC
150 160 170 180 190 200
440 450 460 470 480 490
pF1KB3 RDSSNSCDLPEFCTGASPHCPANVYLHDGHSCQDVDGYCYNGICQTHEQQCVTLWGPGAK
:... .::::::::: :::::.: : :: :. ..:::::.: :...:: ::::::.
XP_011 REQARQCDLPEFCTGKSPHCPTNFYQMDGTPCEGGQAYCYNGMCLTYQEQCQQLWGPGAR
210 220 230 240 250 260
500 510 520 530 540 550
pF1KB3 PAPGICFERVNSAGDPYGNCGKVSKSSFAKCEMRDAKCGKIQCQGGASRPVIGTNAVSIE
::: .:::.:: ::: .::::: .. ::.::::::::::::.. .:: . .::: :.
XP_011 PAPDLCFEKVNVAGDTFGNCGKDMNGEHRKCNMRDAKCGKIQCQSSEARP-LESNAVPID
270 280 290 300 310 320
560 570 580 590 600
pF1KB3 TNIPLQQGGRILCRGTHVYLGD----DMPDPGLVLAGTKCADGKICLNRQCQNISVFGVH
:.: ...: .: ::::::: : :: :::::..::::. ..::.. ::.: : : ..
XP_011 TTI-IMNGRQIQCRGTHVYRGPEEEGDMLDPGLVMTGTKCGYNHICFEGQCRNTSFFETE
330 340 350 360 370 380
610 620 630 640 650 660
pF1KB3 ECAMQCHGRGVCNNRKNCHCEAHWAPPFCDKFGFGGSTDSGPIRQADNQGLTIGILVTIL
:. .:.:.::::: .:::: ::::::. : ::: ::::. . .. :.::.::
XP_011 GCGKKCNGHGVCNNNQNCHCLPGWAPPFCNTPGHGGSIDSGPMPPESVGPVVAGVLVAIL
390 400 410 420 430 440
670 680 690 700 710
pF1KB3 CLLAAGFVVYLKRKTLIRLLFTNKKTTIEKLR----C-VRPSR--------PPRGFQPCQ
: . .. : :.. .: . .. ::: : : :. : .: :
XP_011 VLAVLMLMYYCCRQN-NKLGQLKPSALPSKLRQQFSCPFRVSQNSGTGHANPTFKLQTPQ
450 460 470 480 490 500
720 730 740 750 760 770
pF1KB3 AHLGHLGKG-LMRKP--PDSYPPKDNPRRLLQCQNVDISRPLNGLNVPQPQSTQRVLPPL
.. .. ..::: : :: : : . . : : : : .
XP_011 GKRKVINTPEILRKPSQPPPRPPPDYLRGGSPPAPLPAHLSRAARNSPGPGSQIERTESS
510 520 530 540 550 560
780 790 800 810 820
pF1KB3 HRAPRAPSVPARPLPAKPALRQAQGTCKPNPPQKPLPADPLARTTRLTHALA----RTPG
.: : :.::.: : .: .: :::: :::.:. : . . : ::
XP_011 RRPP-----PSRPIPPAPNCIVSQDFSRPRPPQKALPANPVPGRRSLPRPGGASPLRPPG
570 580 590 600 610
830 840 850 860
pF1KB3 QWETGLR-LAPLRPA-PQYPHQVPRSTHTAYIK
: :: : : :.: :
XP_011 AGPQQSRPLAALAPKFPEYRSQRAGGMISSKI
620 630 640 650
860 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 13:57:34 2016 done: Thu Nov 3 13:57:36 2016
Total Scan time: 13.430 Total Display time: 0.270
Function used was FASTA [36.3.4 Apr, 2011]