Result of FASTA (omim) for
pFN21AB3334
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KB3334, 770 aa
1>>>pF1KB3334 770 - 770 aa - 770 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.4921+/-0.000476; mu= 6.1549+/- 0.030
mean_var=226.5313+/-44.441, 0's: 0 Z-trim(116.2): 104 B-trim: 0 in 0/53
Lambda= 0.085214
statistics sampled from 27159 (27263) to 27159 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.656), E-opt: 0.2 (0.32), width: 16
Scan time: 11.400
The best scores are: opt bits E(85289)
NP_000475 (OMIM: 104300,104760,605714) amyloid bet ( 770) 5160 648.3 3.5e-185
NP_001129602 (OMIM: 104300,104760,605714) amyloid ( 714) 4648 585.3 2.9e-166
NP_001191230 (OMIM: 104300,104760,605714) amyloid ( 752) 4294 541.8 3.8e-153
NP_001129488 (OMIM: 104300,104760,605714) amyloid ( 746) 2674 342.7 3.4e-93
NP_958816 (OMIM: 104300,104760,605714) amyloid bet ( 751) 2674 342.7 3.4e-93
NP_001129601 (OMIM: 104300,104760,605714) amyloid ( 639) 2653 340.0 1.8e-92
NP_001129603 (OMIM: 104300,104760,605714) amyloid ( 660) 2653 340.1 1.9e-92
NP_958817 (OMIM: 104300,104760,605714) amyloid bet ( 695) 2653 340.1 1.9e-92
NP_001191231 (OMIM: 104300,104760,605714) amyloid ( 733) 2431 312.8 3.3e-84
NP_001191232 (OMIM: 104300,104760,605714) amyloid ( 677) 1977 257.0 2e-67
NP_001315615 (OMIM: 104776) amyloid-like protein 2 ( 730) 1295 173.1 3.6e-42
NP_001633 (OMIM: 104776) amyloid-like protein 2 is ( 763) 1295 173.2 3.7e-42
NP_001315611 (OMIM: 104776) amyloid-like protein 2 ( 707) 1269 169.9 3.2e-41
NP_001135748 (OMIM: 104776) amyloid-like protein 2 ( 751) 985 135.0 1.1e-30
NP_001230228 (OMIM: 104776) amyloid-like protein 2 ( 761) 985 135.0 1.1e-30
NP_001135749 (OMIM: 104776) amyloid-like protein 2 ( 695) 959 131.8 9.5e-30
NP_001135750 (OMIM: 104776) amyloid-like protein 2 ( 522) 949 130.5 1.8e-29
NP_001315613 (OMIM: 104776) amyloid-like protein 2 ( 700) 924 127.5 1.9e-28
NP_001315614 (OMIM: 104776) amyloid-like protein 2 ( 644) 898 124.3 1.6e-27
XP_016882227 (OMIM: 104775) PREDICTED: amyloid-lik ( 597) 695 99.3 5e-20
XP_016882226 (OMIM: 104775) PREDICTED: amyloid-lik ( 598) 695 99.3 5e-20
NP_001019978 (OMIM: 104775) amyloid-like protein 1 ( 651) 685 98.1 1.3e-19
NP_005157 (OMIM: 104775) amyloid-like protein 1 is ( 650) 683 97.9 1.5e-19
NP_001159575 (OMIM: 270420,605124) kunitz-type pro ( 195) 236 42.4 0.0022
NP_066925 (OMIM: 270420,605124) kunitz-type protea ( 252) 236 42.5 0.0026
NP_006643 (OMIM: 613941) kunitz-type protease inhi ( 89) 224 40.6 0.0034
>>NP_000475 (OMIM: 104300,104760,605714) amyloid beta A4 (770 aa)
initn: 5160 init1: 5160 opt: 5160 Z-score: 3445.7 bits: 648.3 E(85289): 3.5e-185
Smith-Waterman score: 5160; 100.0% identity (100.0% similar) in 770 aa overlap (1-770:1-770)
10 20 30 40 50 60
pF1KB3 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
610 620 630 640 650 660
670 680 690 700 710 720
pF1KB3 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
670 680 690 700 710 720
730 740 750 760 770
pF1KB3 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
730 740 750 760 770
>>NP_001129602 (OMIM: 104300,104760,605714) amyloid beta (714 aa)
initn: 4648 init1: 4648 opt: 4648 Z-score: 3105.9 bits: 585.3 E(85289): 2.9e-166
Smith-Waterman score: 4648; 100.0% identity (100.0% similar) in 696 aa overlap (75-770:19-714)
50 60 70 80 90 100
pF1KB3 MNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQ
::::::::::::::::::::::::::::::
NP_001 MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQ
10 20 30 40
110 120 130 140 150 160
pF1KB3 CKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTN
50 60 70 80 90 100
170 180 190 200 210 220
pF1KB3 LHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDK
110 120 130 140 150 160
230 240 250 260 270 280
pF1KB3 VVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVE
170 180 190 200 210 220
290 300 310 320 330 340
pF1KB3 EVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSA
230 240 250 260 270 280
350 360 370 380 390 400
pF1KB3 MSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRE
290 300 310 320 330 340
410 420 430 440 450 460
pF1KB3 RMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAM
350 360 370 380 390 400
470 480 490 500 510 520
pF1KB3 LNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAA
410 420 430 440 450 460
530 540 550 560 570 580
pF1KB3 QIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEP
470 480 490 500 510 520
590 600 610 620 630 640
pF1KB3 RISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARP
530 540 550 560 570 580
650 660 670 680 690 700
pF1KB3 AADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIG
590 600 610 620 630 640
710 720 730 740 750 760
pF1KB3 LMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKF
650 660 670 680 690 700
770
pF1KB3 FEQMQN
::::::
NP_001 FEQMQN
710
>>NP_001191230 (OMIM: 104300,104760,605714) amyloid beta (752 aa)
initn: 4294 init1: 4294 opt: 4294 Z-score: 2870.4 bits: 541.8 E(85289): 3.8e-153
Smith-Waterman score: 4993; 97.7% identity (97.7% similar) in 770 aa overlap (1-770:1-752)
10 20 30 40 50 60
pF1KB3 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KB3 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KB3 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KB3 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
490 500 510 520 530 540
550 560 570 580 590 600
pF1KB3 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
550 560 570 580 590 600
610 620 630 640 650 660
pF1KB3 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
:::::::::::::::::::::::::::::::::::: ::::::
NP_001 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENE------------------GSGLTN
610 620 630 640
670 680 690 700 710 720
pF1KB3 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
650 660 670 680 690 700
730 740 750 760 770
pF1KB3 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
710 720 730 740 750
>>NP_001129488 (OMIM: 104300,104760,605714) amyloid beta (746 aa)
initn: 2640 init1: 2640 opt: 2674 Z-score: 1794.1 bits: 342.7 E(85289): 3.4e-93
Smith-Waterman score: 4872; 97.3% identity (97.5% similar) in 751 aa overlap (20-770:15-746)
10 20 30 40 50 60
pF1KB3 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
:::::::::::::::::::::::::::::::::::::::::
NP_001 MDQLEDLLVLFINYVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
10 20 30 40 50
70 80 90 100 110 120
pF1KB3 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
60 70 80 90 100 110
130 140 150 160 170 180
pF1KB3 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
120 130 140 150 160 170
190 200 210 220 230 240
pF1KB3 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
180 190 200 210 220 230
250 260 270 280 290 300
pF1KB3 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
240 250 260 270 280 290
310 320 330 340 350 360
pF1KB3 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
::::::::::::::::::::::::::::::::::::::::::::.
NP_001 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAI---------------
300 310 320 330 340
370 380 390 400 410 420
pF1KB3 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ----PTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
350 360 370 380 390
430 440 450 460 470 480
pF1KB3 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
400 410 420 430 440 450
490 500 510 520 530 540
pF1KB3 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
460 470 480 490 500 510
550 560 570 580 590 600
pF1KB3 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
520 530 540 550 560 570
610 620 630 640 650 660
pF1KB3 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
580 590 600 610 620 630
670 680 690 700 710 720
pF1KB3 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
640 650 660 670 680 690
730 740 750 760 770
pF1KB3 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
700 710 720 730 740
>>NP_958816 (OMIM: 104300,104760,605714) amyloid beta A4 (751 aa)
initn: 2640 init1: 2640 opt: 2674 Z-score: 1794.1 bits: 342.7 E(85289): 3.4e-93
Smith-Waterman score: 4990; 97.4% identity (97.5% similar) in 770 aa overlap (1-770:1-751)
10 20 30 40 50 60
pF1KB3 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
::::::::::::::::::::::::::::::::::::::::::::.
NP_958 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAI---------------
310 320 330 340
370 380 390 400 410 420
pF1KB3 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 ----PTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
350 360 370 380 390 400
430 440 450 460 470 480
pF1KB3 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
410 420 430 440 450 460
490 500 510 520 530 540
pF1KB3 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
470 480 490 500 510 520
550 560 570 580 590 600
pF1KB3 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
530 540 550 560 570 580
610 620 630 640 650 660
pF1KB3 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
590 600 610 620 630 640
670 680 690 700 710 720
pF1KB3 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
650 660 670 680 690 700
730 740 750 760 770
pF1KB3 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
710 720 730 740 750
>>NP_001129601 (OMIM: 104300,104760,605714) amyloid beta (639 aa)
initn: 2759 init1: 2650 opt: 2653 Z-score: 1781.0 bits: 340.0 E(85289): 1.8e-92
Smith-Waterman score: 3944; 89.1% identity (89.2% similar) in 696 aa overlap (75-770:19-639)
50 60 70 80 90 100
pF1KB3 MNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQ
::::::::::::::::::::::::::::::
NP_001 MLPGLALLLLAAWTARALEVYPELQITNVVEANQPVTIQNWCKRGRKQ
10 20 30 40
110 120 130 140 150 160
pF1KB3 CKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTN
50 60 70 80 90 100
170 180 190 200 210 220
pF1KB3 LHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDK
110 120 130 140 150 160
230 240 250 260 270 280
pF1KB3 VVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVE
170 180 190 200 210 220
290 300 310 320 330 340
pF1KB3 EVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSA
::::
NP_001 EVVR--------------------------------------------------------
230
350 360 370 380 390 400
pF1KB3 MSQSLLKTTQEPLARDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRE
.::::::::::::::::::::::::::::::::::::::::
NP_001 -------------------VPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRE
240 250 260 270
410 420 430 440 450 460
pF1KB3 RMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAM
280 290 300 310 320 330
470 480 490 500 510 520
pF1KB3 LNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAA
340 350 360 370 380 390
530 540 550 560 570 580
pF1KB3 QIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEP
400 410 420 430 440 450
590 600 610 620 630 640
pF1KB3 RISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARP
460 470 480 490 500 510
650 660 670 680 690 700
pF1KB3 AADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIG
520 530 540 550 560 570
710 720 730 740 750 760
pF1KB3 LMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKF
580 590 600 610 620 630
770
pF1KB3 FEQMQN
::::::
NP_001 FEQMQN
>>NP_001129603 (OMIM: 104300,104760,605714) amyloid beta (660 aa)
initn: 2650 init1: 2650 opt: 2653 Z-score: 1780.9 bits: 340.1 E(85289): 1.9e-92
Smith-Waterman score: 4234; 89.7% identity (89.8% similar) in 735 aa overlap (36-770:1-660)
10 20 30 40 50 60
pF1KB3 ALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDT
::::::::::::::::::::::::::::::
NP_001 MFCGRLNMHMNVQNGKWDSDPSGTKTCIDT
10 20 30
70 80 90 100 110 120
pF1KB3 KEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSD
40 50 60 70 80 90
130 140 150 160 170 180
pF1KB3 ALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFV
100 110 120 130 140 150
190 200 210 220 230 240
pF1KB3 CCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDD
160 170 180 190 200 210
250 260 270 280 290 300
pF1KB3 EDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMIS
:::::::::::::::::::::::::::::::::::::::::::
NP_001 EDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVR-----------------
220 230 240 250
310 320 330 340 350 360
pF1KB3 RWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARDPVKLP
.:
NP_001 ----------------------------------------------------------VP
370 380 390 400 410 420
pF1KB3 TTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPK
260 270 280 290 300 310
430 440 450 460 470 480
pF1KB3 ADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPP
320 330 340 350 360 370
490 500 510 520 530 540
pF1KB3 RPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSL
380 390 400 410 420 430
550 560 570 580 590 600
pF1KB3 SLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVE
440 450 460 470 480 490
610 620 630 640 650 660
pF1KB3 LLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEE
500 510 520 530 540 550
670 680 690 700 710 720
pF1KB3 ISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKK
560 570 580 590 600 610
730 740 750 760 770
pF1KB3 KQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
:::::::::::::::::::::::::::::::::::::::::::::
NP_001 KQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
620 630 640 650 660
>>NP_958817 (OMIM: 104300,104760,605714) amyloid beta A4 (695 aa)
initn: 2650 init1: 2650 opt: 2653 Z-score: 1780.6 bits: 340.1 E(85289): 1.9e-92
Smith-Waterman score: 4456; 90.1% identity (90.3% similar) in 770 aa overlap (1-770:1-695)
10 20 30 40 50 60
pF1KB3 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVR------------
250 260 270 280
310 320 330 340 350 360
pF1KB3 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
NP_958 ------------------------------------------------------------
370 380 390 400 410 420
pF1KB3 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 ---VPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
290 300 310 320 330 340
430 440 450 460 470 480
pF1KB3 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
350 360 370 380 390 400
490 500 510 520 530 540
pF1KB3 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
410 420 430 440 450 460
550 560 570 580 590 600
pF1KB3 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
470 480 490 500 510 520
610 620 630 640 650 660
pF1KB3 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
530 540 550 560 570 580
670 680 690 700 710 720
pF1KB3 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
590 600 610 620 630 640
730 740 750 760 770
pF1KB3 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_958 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
650 660 670 680 690
>>NP_001191231 (OMIM: 104300,104760,605714) amyloid beta (733 aa)
initn: 3134 init1: 2401 opt: 2431 Z-score: 1632.8 bits: 312.8 E(85289): 3.3e-84
Smith-Waterman score: 4823; 95.1% identity (95.2% similar) in 770 aa overlap (1-770:1-733)
10 20 30 40 50 60
pF1KB3 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KB3 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
::::::::::::::::::::::::::::::::::::::::::::.
NP_001 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAI---------------
310 320 330 340
370 380 390 400 410 420
pF1KB3 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ----PTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
350 360 370 380 390 400
430 440 450 460 470 480
pF1KB3 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
410 420 430 440 450 460
490 500 510 520 530 540
pF1KB3 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
470 480 490 500 510 520
550 560 570 580 590 600
pF1KB3 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
530 540 550 560 570 580
610 620 630 640 650 660
pF1KB3 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
:::::::::::::::::::::::::::::::::::: ::::::
NP_001 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENE------------------GSGLTN
590 600 610 620
670 680 690 700 710 720
pF1KB3 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
630 640 650 660 670 680
730 740 750 760 770
pF1KB3 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
690 700 710 720 730
>>NP_001191232 (OMIM: 104300,104760,605714) amyloid beta (677 aa)
initn: 2710 init1: 1977 opt: 1977 Z-score: 1331.6 bits: 257.0 E(85289): 2e-67
Smith-Waterman score: 4289; 87.8% identity (87.9% similar) in 770 aa overlap (1-770:1-677)
10 20 30 40 50 60
pF1KB3 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KB3 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KB3 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KB3 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KB3 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPC
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVR------------
250 260 270 280
310 320 330 340 350 360
pF1KB3 RAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSAMSQSLLKTTQEPLARD
NP_001 ------------------------------------------------------------
370 380 390 400 410 420
pF1KB3 PVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ---VPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQA
290 300 310 320 330 340
430 440 450 460 470 480
pF1KB3 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITAL
350 360 370 380 390 400
490 500 510 520 530 540
pF1KB3 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYER
410 420 430 440 450 460
550 560 570 580 590 600
pF1KB3 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTET
470 480 490 500 510 520
610 620 630 640 650 660
pF1KB3 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTN
:::::::::::::::::::::::::::::::::::: ::::::
NP_001 KTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENE------------------GSGLTN
530 540 550 560
670 680 690 700 710 720
pF1KB3 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITL
570 580 590 600 610 620
730 740 750 760 770
pF1KB3 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN
630 640 650 660 670
770 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 12:55:04 2016 done: Thu Nov 3 12:55:05 2016
Total Scan time: 11.400 Total Display time: 0.180
Function used was FASTA [36.3.4 Apr, 2011]