Result of FASTA (omim) for
pFN21ASDA1158
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA1158, 215 aa
1>>>pF1KSDA1158 215 - 215 aa - 215 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1222+/-0.000423; mu= 15.1128+/- 0.026
mean_var=85.0290+/-17.204, 0's: 0 Z-trim(111.9): 97 B-trim: 402 in 1/54
Lambda= 0.139088
statistics sampled from 20504 (20605) to 20504 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.62), E-opt: 0.2 (0.242), width: 16
Scan time: 5.790
The best scores are: opt bits E(85289)
NP_060870 (OMIM: 608214,613120) sodium channel sub ( 215) 1430 296.8 1.8e-80
XP_011541199 (OMIM: 608214,613120) PREDICTED: sodi ( 215) 1430 296.8 1.8e-80
NP_001035241 (OMIM: 608214,613120) sodium channel ( 215) 1430 296.8 1.8e-80
NP_001028 (OMIM: 600235,604233,612838,615377) sodi ( 218) 604 131.0 1.4e-30
NP_001308534 (OMIM: 600235,604233,612838,615377) s ( 185) 537 117.5 1.4e-26
NP_950238 (OMIM: 600235,604233,612838,615377) sodi ( 268) 337 77.5 2.2e-14
NP_000521 (OMIM: 118200,145900,159440,180800,60525 ( 248) 229 55.8 7.1e-08
NP_001302420 (OMIM: 118200,145900,159440,180800,60 ( 312) 229 55.9 8.3e-08
XP_016856810 (OMIM: 118200,145900,159440,180800,60 ( 240) 226 55.2 1e-07
NP_938016 (OMIM: 611707) myelin protein zero-like ( 235) 211 52.2 8.3e-07
XP_016872793 (OMIM: 611707) PREDICTED: myelin prot ( 219) 193 48.6 9.7e-06
NP_005788 (OMIM: 604873) myelin protein zero-like ( 215) 190 48.0 1.4e-05
NP_658911 (OMIM: 604873) myelin protein zero-like ( 215) 190 48.0 1.4e-05
XP_006718838 (OMIM: 611707) PREDICTED: myelin prot ( 217) 190 48.0 1.5e-05
NP_001273081 (OMIM: 611707) myelin protein zero-li ( 223) 179 45.8 6.9e-05
NP_003944 (OMIM: 604376) myelin protein zero-like ( 269) 176 45.2 0.00012
NP_078845 (OMIM: 604376) myelin protein zero-like ( 209) 172 44.3 0.00017
NP_004579 (OMIM: 601327,615378) sodium channel sub ( 215) 155 40.9 0.0019
XP_011510776 (OMIM: 608351) PREDICTED: immunoglobu ( 323) 150 40.1 0.005
XP_011510773 (OMIM: 608351) PREDICTED: immunoglobu ( 429) 150 40.2 0.0062
XP_011510770 (OMIM: 608351) PREDICTED: immunoglobu ( 443) 150 40.2 0.0063
XP_011510769 (OMIM: 608351) PREDICTED: immunoglobu ( 453) 150 40.2 0.0064
XP_011510768 (OMIM: 608351) PREDICTED: immunoglobu ( 457) 150 40.2 0.0065
XP_011510765 (OMIM: 608351) PREDICTED: immunoglobu ( 480) 150 40.3 0.0067
XP_011510766 (OMIM: 608351) PREDICTED: immunoglobu ( 480) 150 40.3 0.0067
XP_011510767 (OMIM: 608351) PREDICTED: immunoglobu ( 480) 150 40.3 0.0067
XP_011510764 (OMIM: 608351) PREDICTED: immunoglobu ( 481) 150 40.3 0.0067
>>NP_060870 (OMIM: 608214,613120) sodium channel subunit (215 aa)
initn: 1430 init1: 1430 opt: 1430 Z-score: 1565.6 bits: 296.8 E(85289): 1.8e-80
Smith-Waterman score: 1430; 100.0% identity (100.0% similar) in 215 aa overlap (1-215:1-215)
10 20 30 40 50 60
pF1KSD MPAFNRLFPLASLVLIYWVSVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MPAFNRLFPLASLVLIYWVSVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD EWFYRPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQDVSITVLNVTLNDSGLYTC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 EWFYRPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQDVSITVLNVTLNDSGLYTC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD NVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLLIEMIYC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 NVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLLIEMIYC
130 140 150 160 170 180
190 200 210
pF1KSD YRKVSKAEEAAQENASDYLAIPSENKENSAVPVEE
:::::::::::::::::::::::::::::::::::
NP_060 YRKVSKAEEAAQENASDYLAIPSENKENSAVPVEE
190 200 210
>>XP_011541199 (OMIM: 608214,613120) PREDICTED: sodium c (215 aa)
initn: 1430 init1: 1430 opt: 1430 Z-score: 1565.6 bits: 296.8 E(85289): 1.8e-80
Smith-Waterman score: 1430; 100.0% identity (100.0% similar) in 215 aa overlap (1-215:1-215)
10 20 30 40 50 60
pF1KSD MPAFNRLFPLASLVLIYWVSVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MPAFNRLFPLASLVLIYWVSVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD EWFYRPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQDVSITVLNVTLNDSGLYTC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EWFYRPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQDVSITVLNVTLNDSGLYTC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD NVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLLIEMIYC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLLIEMIYC
130 140 150 160 170 180
190 200 210
pF1KSD YRKVSKAEEAAQENASDYLAIPSENKENSAVPVEE
:::::::::::::::::::::::::::::::::::
XP_011 YRKVSKAEEAAQENASDYLAIPSENKENSAVPVEE
190 200 210
>>NP_001035241 (OMIM: 608214,613120) sodium channel subu (215 aa)
initn: 1430 init1: 1430 opt: 1430 Z-score: 1565.6 bits: 296.8 E(85289): 1.8e-80
Smith-Waterman score: 1430; 100.0% identity (100.0% similar) in 215 aa overlap (1-215:1-215)
10 20 30 40 50 60
pF1KSD MPAFNRLFPLASLVLIYWVSVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPAFNRLFPLASLVLIYWVSVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD EWFYRPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQDVSITVLNVTLNDSGLYTC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EWFYRPEGGKDFLIYEYRNGHQEVESPFQGRLQWNGSKDLQDVSITVLNVTLNDSGLYTC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD NVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLLIEMIYC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLLIEMIYC
130 140 150 160 170 180
190 200 210
pF1KSD YRKVSKAEEAAQENASDYLAIPSENKENSAVPVEE
:::::::::::::::::::::::::::::::::::
NP_001 YRKVSKAEEAAQENASDYLAIPSENKENSAVPVEE
190 200 210
>>NP_001028 (OMIM: 600235,604233,612838,615377) sodium c (218 aa)
initn: 553 init1: 313 opt: 604 Z-score: 669.8 bits: 131.0 E(85289): 1.4e-30
Smith-Waterman score: 604; 49.5% identity (72.9% similar) in 214 aa overlap (10-215:5-218)
10 20 30 40 50 60
pF1KSD MPAFNRLFPLASLVLIYWVSVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVV
:: .: :: :::: :::::: : .:. :::: .: :..: : .
NP_001 MGRLLALVVGAALVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFT
10 20 30 40 50
70 80 90 100 110
pF1KSD EWFYRPEGGKDFL-IYEYRNGHQEVESP--FQGRLQWNGS---KDLQDVSITVLNVTLND
:: .: .: ..:. : .:.: ..: :.::. :::: :::::.:: . ::: :
NP_001 EWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNH
60 70 80 90 100 110
120 130 140 150 160 170
pF1KSD SGLYTCNVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLL
:: : :.: : . :: .. ..... : ..:...:..:..:.:::::::.:.: ::.::.
NP_001 SGDYECHVYRLLFFENYEHNTSVVKKIHIEVVDKANRDMASIVSEIMMYVLIVVLTIWLV
120 130 140 150 160 170
180 190 200 210
pF1KSD IEMIYCYRKVSKAEE-AAQENASDYLAIPSENKEN-SAVPVEE
::::::.:.. : : :::::::.:::: ::.::: ..: : :
NP_001 AEMIYCYKKIAAATETAAQENASEYLAITSESKENCTGVQVAE
180 190 200 210
>>NP_001308534 (OMIM: 600235,604233,612838,615377) sodiu (185 aa)
initn: 481 init1: 313 opt: 537 Z-score: 598.0 bits: 117.5 E(85289): 1.4e-26
Smith-Waterman score: 537; 49.5% identity (75.8% similar) in 182 aa overlap (42-215:4-185)
20 30 40 50 60 70
pF1KSD SLVLIYWVSVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVVEWFYRPEGGKD
:. :::: .: :..: : .:: .: .: ..
NP_001 MTFKILCISCKRRSETNAETFTEWTFRQKGTEE
10 20 30
80 90 100 110 120
pF1KSD FL-IYEYRNGHQEVESP--FQGRLQWNGS---KDLQDVSITVLNVTLNDSGLYTCNVSRE
:. : .:.: ..: :.::. :::: :::::.:: . ::: : :: : :.: :
NP_001 FVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHVYRL
40 50 60 70 80 90
130 140 150 160 170 180
pF1KSD FEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLLIEMIYCYRKVS
. :: .. ..... : ..:...:..:..:.:::::::.:.: ::.::. ::::::.:..
NP_001 LFFENYEHNTSVVKKIHIEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMIYCYKKIA
100 110 120 130 140 150
190 200 210
pF1KSD KAEE-AAQENASDYLAIPSENKEN-SAVPVEE
: : :::::::.:::: ::.::: ..: : :
NP_001 AATETAAQENASEYLAITSESKENCTGVQVAE
160 170 180
>>NP_950238 (OMIM: 600235,604233,612838,615377) sodium c (268 aa)
initn: 342 init1: 177 opt: 337 Z-score: 379.1 bits: 77.5 E(85289): 2.2e-14
Smith-Waterman score: 337; 43.2% identity (66.2% similar) in 148 aa overlap (10-151:5-151)
10 20 30 40 50 60
pF1KSD MPAFNRLFPLASLVLIYWVSVCFPVCVEVPSETEAVQGNPMKLRCISCMKREEVEATTVV
:: .: :: :::: :::::: : .:. :::: .: :..: : .
NP_950 MGRLLALVVGAALVSSACGGCVEVDSETEAVYGMTFKILCISCKRRSETNAETFT
10 20 30 40 50
70 80 90 100 110
pF1KSD EWFYRPEGGKDFL-IYEYRNGHQEVESP--FQGRLQWNGS---KDLQDVSITVLNVTLND
:: .: .: ..:. : .:.: ..: :.::. :::: :::::.:: . ::: :
NP_950 EWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNH
60 70 80 90 100 110
120 130 140 150 160 170
pF1KSD SGLYTCNVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLWLL
:: : :.: : . :: .. ..... : ..:... ::
NP_950 SGDYECHVYRLLFFENYEHNTSVVKKIHIEVVDK-GESGAACPFTVTHRRARWRDRWQAV
120 130 140 150 160 170
180 190 200 210
pF1KSD IEMIYCYRKVSKAEEAAQENASDYLAIPSENKENSAVPVEE
NP_950 DRTGWLCAWPANRPQQRAEGEGSSPSCPLQLWPLFLSSPRRGQSMPVPHRRSGYRTQLCH
180 190 200 210 220 230
>>NP_000521 (OMIM: 118200,145900,159440,180800,605253,60 (248 aa)
initn: 136 init1: 107 opt: 229 Z-score: 262.4 bits: 55.8 E(85289): 7.1e-08
Smith-Waterman score: 229; 26.7% identity (56.7% similar) in 210 aa overlap (14-213:16-218)
10 20 30 40 50
pF1KSD MPAFNRLFPLASLVLIYWVSVCFP---VCVEVPSETEAVQGNPMKLRCISCMKREEVE
::.. : : . : . :.... :. . :.: : . : :
NP_000 MAPGAPSSSPSPILAVLLFSSLVLSPAQAIVVYTDREVHGAVGSRVTLHC-SFWSSEWVS
10 20 30 40 50
60 70 80 90 100 110
pF1KSD ATTVVEWFYRPEGGKDFL-IYEYRNGHQEVE--SPFQGRLQWNGSKDLQDVSITVLNVTL
: :.::::.: . :..: .:. .. . :. :.:: :. .: ::.. :.
NP_000 DDISFTWRYQPEGGRDAISIFHYAKGQPYIDEVGTFKERIQWVGDPRWKDGSIVIHNLDY
60 70 80 90 100 110
120 130 140 150 160 170
pF1KSD NDSGLYTCNVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLW
.:.: .::.:. .. : : . : : :.. . :.. .. .: : : :
NP_000 SDNGTFTCDVKNPPDI------VGKTSQVTLYVFEKVPTRYGVVLGAVIGGVLGVVLLLL
120 130 140 150 160 170
180 190 200 210
pF1KSD LLIEMI-YCYRKVSKAEE---AAQENASDYLAIPSENKENSAVPVEE
::. .. ::. . . : . .:.:... . . .:.. .::
NP_000 LLFYVVRYCWLRRQAALQRRLSAMEKGKLHKPGKDASKRGRQTPVLYAMLDHSRSTKAVS
180 190 200 210 220 230
NP_000 EKKAKGLGESRKDKK
240
>>NP_001302420 (OMIM: 118200,145900,159440,180800,605253 (312 aa)
initn: 136 init1: 107 opt: 229 Z-score: 261.1 bits: 55.9 E(85289): 8.3e-08
Smith-Waterman score: 229; 26.7% identity (56.7% similar) in 210 aa overlap (14-213:16-218)
10 20 30 40 50
pF1KSD MPAFNRLFPLASLVLIYWVSVCFP---VCVEVPSETEAVQGNPMKLRCISCMKREEVE
::.. : : . : . :.... :. . :.: : . : :
NP_001 MAPGAPSSSPSPILAVLLFSSLVLSPAQAIVVYTDREVHGAVGSRVTLHC-SFWSSEWVS
10 20 30 40 50
60 70 80 90 100 110
pF1KSD ATTVVEWFYRPEGGKDFL-IYEYRNGHQEVE--SPFQGRLQWNGSKDLQDVSITVLNVTL
: :.::::.: . :..: .:. .. . :. :.:: :. .: ::.. :.
NP_001 DDISFTWRYQPEGGRDAISIFHYAKGQPYIDEVGTFKERIQWVGDPRWKDGSIVIHNLDY
60 70 80 90 100 110
120 130 140 150 160 170
pF1KSD NDSGLYTCNVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTLW
.:.: .::.:. .. : : . : : :.. . :.. .. .: : : :
NP_001 SDNGTFTCDVKNPPDI------VGKTSQVTLYVFEKVPTRYGVVLGAVIGGVLGVVLLLL
120 130 140 150 160 170
180 190 200 210
pF1KSD LLIEMI-YCYRKVSKAEE---AAQENASDYLAIPSENKENSAVPVEE
::. .. ::. . . : . .:.:... . . .:.. .::
NP_001 LLFYVVRYCWLRRQAALQRRLSAMEKGKLHKPGKDASKRGRQTPVLYAMLDHSRSTKAVS
180 190 200 210 220 230
NP_001 EKKAKGLGESRKDKKXRLAGRAGDRGLGVESAKGPKVMVIEMELRKDEQSPELRPAVKSP
240 250 260 270 280 290
>>XP_016856810 (OMIM: 118200,145900,159440,180800,605253 (240 aa)
initn: 136 init1: 107 opt: 226 Z-score: 259.3 bits: 55.2 E(85289): 1e-07
Smith-Waterman score: 226; 28.2% identity (56.4% similar) in 181 aa overlap (14-187:26-199)
10 20 30 40
pF1KSD MPAFNRLFPLASLVLIYWVSVCFP---VCVEVPSETEAVQGNPMKLRC
::.. : : . : . :.... :. . :.:
XP_016 MLRAPAPAPAMAPGAPSSSPSPILAVLLFSSLVLSPAQAIVVYTDREVHGAVGSRVTLHC
10 20 30 40 50 60
50 60 70 80 90 100
pF1KSD ISCMKREEVEATTVVEWFYRPEGGKDFL-IYEYRNGHQEVE--SPFQGRLQWNGSKDLQD
: . : : : :.::::.: . :..: .:. .. . :. :.:: :. .:
XP_016 -SFWSSEWVSDDISFTWRYQPEGGRDAISIFHYAKGQPYIDEVGTFKERIQWVGDPRWKD
70 80 90 100 110
110 120 130 140 150 160
pF1KSD VSITVLNVTLNDSGLYTCNVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMM
::.. :. .:.: .::.:. .. : : . : : :.. . :.. ..
XP_016 GSIVIHNLDYSDNGTFTCDVKNPPDI------VGKTSQVTLYVFEKVPTRYGVVLGAVIG
120 130 140 150 160 170
170 180 190 200 210
pF1KSD YILLVFLTLWLLIEMI-YCYRKVSKAEEAAQENASDYLAIPSENKENSAVPVEE
.: : : : ::. .. ::. . . :
XP_016 GVLGVVLLLLLLFYVVRYCWLRRQAALQRRLSAMEKGKLHKPGKDASKRGRQGFYNNQMR
180 190 200 210 220 230
>>NP_938016 (OMIM: 611707) myelin protein zero-like prot (235 aa)
initn: 130 init1: 72 opt: 211 Z-score: 243.2 bits: 52.2 E(85289): 8.3e-07
Smith-Waterman score: 215; 22.7% identity (58.3% similar) in 211 aa overlap (7-215:14-213)
10 20 30 40 50
pF1KSD MPAFNRLFPLASLVLIYWVSVCFPVCVEVPSETEAVQGNPMKLRCISCMKREE
:::: ..... : . : . ... ..... :. .::.: . . .
NP_938 MQQRGAAGSRGCALFPLLGVLFFQGVYIVFSLEIRADAHVRGYVGEKIKLKC-TFKSTSD
10 20 30 40 50
60 70 80 90 100 110
pF1KSD VEATTVVEWFYRPEGGKDFL-IYEYRN-GHQEVESPFQGRLQWNGSKDLQDVSITVLNVT
: ...: ::: ... . :..:.. . . . :. :..: :. :.::.. : :
NP_938 VTDKLTIDWTYRPPSSSHTVSIFHYQSFQYPTTAGTFRDRISWVGNVYKGDASISISNPT
60 70 80 90 100 110
120 130 140 150 160 170
pF1KSD LNDSGLYTCNVSREFEFEAHRPFVKTTRLIPLRVTEEAGEDFTSVVSEIMMYILLVFLTL
..:.: ..: :. . . . :... : :::.. : ...: . . .:::.
NP_938 IKDNGTFSCAVKNPPDVHHNIPMTE------LTVTERG---FGTMLSSVALLSILVFVPS
120 130 140 150 160 170
180 190 200 210
pF1KSD WLLIEMIYCYRKVSKAEEAAQENASDYLAIPSENKENSAVPVEE
... .. : :: ... : : : .... ::
NP_938 AVVVALLLV-RMGRKAAGLKKRSRSGYKKSSIEVSDDTDQEEEEACMARLCVRCAECLDS
180 190 200 210 220
NP_938 DYEETY
230
215 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 05:11:04 2016 done: Thu Nov 3 05:11:05 2016
Total Scan time: 5.790 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]