Result of FASTA (ccds) for
pFN21ASDA0388
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA0388, 747 aa
1>>>pF1KSDA0388 747 - 747 aa - 747 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.2690+/-0.00105; mu= 17.3299+/- 0.064
mean_var=140.8176+/-26.007, 0's: 0 Z-trim(109.1): 63 B-trim: 0 in 0/51
Lambda= 0.108080
statistics sampled from 10570 (10626) to 10570 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.685), E-opt: 0.2 (0.326), width: 16
Scan time: 2.740
The best scores are: opt bits E(32554)
CCDS32659.1 EZH1 gene_id:2145|Hs108|chr17 ( 747) 5206 824.1 0
CCDS82130.1 EZH1 gene_id:2145|Hs108|chr17 ( 738) 4666 739.9 3.3e-213
CCDS82129.1 EZH1 gene_id:2145|Hs108|chr17 ( 707) 4383 695.8 6.1e-200
CCDS56516.1 EZH2 gene_id:2146|Hs108|chr7 ( 746) 2701 433.5 5.7e-121
CCDS5891.1 EZH2 gene_id:2146|Hs108|chr7 ( 751) 2624 421.5 2.3e-117
CCDS56518.1 EZH2 gene_id:2146|Hs108|chr7 ( 737) 2491 400.8 4.1e-111
CCDS5892.1 EZH2 gene_id:2146|Hs108|chr7 ( 707) 2354 379.4 1.1e-104
CCDS56517.1 EZH2 gene_id:2146|Hs108|chr7 ( 695) 1262 209.1 1.9e-53
>>CCDS32659.1 EZH1 gene_id:2145|Hs108|chr17 (747 aa)
initn: 5206 init1: 5206 opt: 5206 Z-score: 4396.3 bits: 824.1 E(32554): 0
Smith-Waterman score: 5206; 100.0% identity (100.0% similar) in 747 aa overlap (1-747:1-747)
10 20 30 40 50 60
pF1KSD MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD KKLRVQPVQSMKPVSGHPFLKKCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 KKLRVQPVQSMKPVSGHPFLKKCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD FMVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 FMVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD DALNQYSDEEEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGNKKSSKKQFPNDMIFSAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 DALNQYSDEEEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGNKKSSKKQFPNDMIFSAI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD ASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHTLFCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 ASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHTLFCR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD RCFKYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAMLHNPRSKCSGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 RCFKYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAMLHNPRSKCSGR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD RRRRHHIVSASCSNASASAVAETKEGDSDRDTGNDWASSSSEANSRCQTPTKQKASPAPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 RRRRHHIVSASCSNASASAVAETKEGDSDRDTGNDWASSSSEANSRCQTPTKQKASPAPP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD QLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKESLILK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 QLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKESLILK
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD LPTDELMNPSQKKKRKHRLWAAHCRKIQLKKDNSSTQVYNYQPCDHPDRPCDSTCPCIMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 LPTDELMNPSQKKKRKHRLWAAHCRKIQLKKDNSSTQVYNYQPCDHPDRPCDSTCPCIMT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD QNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 QNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVV
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD SCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 SCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD KYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS32 KYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAG
670 680 690 700 710 720
730 740
pF1KSD EELFFDYRYSQADALKYVGIERETDVL
:::::::::::::::::::::::::::
CCDS32 EELFFDYRYSQADALKYVGIERETDVL
730 740
>>CCDS82130.1 EZH1 gene_id:2145|Hs108|chr17 (738 aa)
initn: 4664 init1: 4664 opt: 4666 Z-score: 3941.3 bits: 739.9 E(32554): 3.3e-213
Smith-Waterman score: 5115; 98.8% identity (98.8% similar) in 747 aa overlap (1-747:1-738)
10 20 30 40 50 60
pF1KSD MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD KKLRVQPVQSMKPVSGHPFLKKCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQN
::::::::::::: ::::::::::::::::::::::::::::::::::::::
CCDS82 KKLRVQPVQSMKP---------CTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQN
70 80 90 100 110
130 140 150 160 170 180
pF1KSD FMVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 FMVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELV
120 130 140 150 160 170
190 200 210 220 230 240
pF1KSD DALNQYSDEEEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGNKKSSKKQFPNDMIFSAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 DALNQYSDEEEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGNKKSSKKQFPNDMIFSAI
180 190 200 210 220 230
250 260 270 280 290 300
pF1KSD ASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHTLFCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 ASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHTLFCR
240 250 260 270 280 290
310 320 330 340 350 360
pF1KSD RCFKYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAMLHNPRSKCSGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 RCFKYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAMLHNPRSKCSGR
300 310 320 330 340 350
370 380 390 400 410 420
pF1KSD RRRRHHIVSASCSNASASAVAETKEGDSDRDTGNDWASSSSEANSRCQTPTKQKASPAPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 RRRRHHIVSASCSNASASAVAETKEGDSDRDTGNDWASSSSEANSRCQTPTKQKASPAPP
360 370 380 390 400 410
430 440 450 460 470 480
pF1KSD QLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKESLILK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 QLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKESLILK
420 430 440 450 460 470
490 500 510 520 530 540
pF1KSD LPTDELMNPSQKKKRKHRLWAAHCRKIQLKKDNSSTQVYNYQPCDHPDRPCDSTCPCIMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 LPTDELMNPSQKKKRKHRLWAAHCRKIQLKKDNSSTQVYNYQPCDHPDRPCDSTCPCIMT
480 490 500 510 520 530
550 560 570 580 590 600
pF1KSD QNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 QNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVV
540 550 560 570 580 590
610 620 630 640 650 660
pF1KSD SCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 SCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYD
600 610 620 630 640 650
670 680 690 700 710 720
pF1KSD KYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 KYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAG
660 670 680 690 700 710
730 740
pF1KSD EELFFDYRYSQADALKYVGIERETDVL
:::::::::::::::::::::::::::
CCDS82 EELFFDYRYSQADALKYVGIERETDVL
720 730
>>CCDS82129.1 EZH1 gene_id:2145|Hs108|chr17 (707 aa)
initn: 4382 init1: 4382 opt: 4383 Z-score: 3703.0 bits: 695.8 E(32554): 6.1e-200
Smith-Waterman score: 4842; 94.6% identity (94.6% similar) in 747 aa overlap (1-747:1-707)
10 20 30 40 50 60
pF1KSD MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD KKLRVQPVQSMKPVSGHPFLKKCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQN
::::::::::::::::::::::
CCDS82 KKLRVQPVQSMKPVSGHPFLKK--------------------------------------
70 80
130 140 150 160 170 180
pF1KSD FMVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 --VEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELV
90 100 110 120 130 140
190 200 210 220 230 240
pF1KSD DALNQYSDEEEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGNKKSSKKQFPNDMIFSAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 DALNQYSDEEEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGNKKSSKKQFPNDMIFSAI
150 160 170 180 190 200
250 260 270 280 290 300
pF1KSD ASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHTLFCR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 ASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHTLFCR
210 220 230 240 250 260
310 320 330 340 350 360
pF1KSD RCFKYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAMLHNPRSKCSGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 RCFKYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAMLHNPRSKCSGR
270 280 290 300 310 320
370 380 390 400 410 420
pF1KSD RRRRHHIVSASCSNASASAVAETKEGDSDRDTGNDWASSSSEANSRCQTPTKQKASPAPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 RRRRHHIVSASCSNASASAVAETKEGDSDRDTGNDWASSSSEANSRCQTPTKQKASPAPP
330 340 350 360 370 380
430 440 450 460 470 480
pF1KSD QLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKESLILK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 QLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCSIARLLGTKTCKQVFQFAVKESLILK
390 400 410 420 430 440
490 500 510 520 530 540
pF1KSD LPTDELMNPSQKKKRKHRLWAAHCRKIQLKKDNSSTQVYNYQPCDHPDRPCDSTCPCIMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 LPTDELMNPSQKKKRKHRLWAAHCRKIQLKKDNSSTQVYNYQPCDHPDRPCDSTCPCIMT
450 460 470 480 490 500
550 560 570 580 590 600
pF1KSD QNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 QNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPCYLAVRECDPDLCLTCGASEHWDCKVV
510 520 530 540 550 560
610 620 630 640 650 660
pF1KSD SCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 SCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQKNEFISEYCGELISQDEADRRGKVYD
570 580 590 600 610 620
670 680 690 700 710 720
pF1KSD KYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 KYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVVMVNGDHRIGIFAKRAIQAG
630 640 650 660 670 680
730 740
pF1KSD EELFFDYRYSQADALKYVGIERETDVL
:::::::::::::::::::::::::::
CCDS82 EELFFDYRYSQADALKYVGIERETDVL
690 700
>>CCDS56516.1 EZH2 gene_id:2146|Hs108|chr7 (746 aa)
initn: 3051 init1: 1795 opt: 2701 Z-score: 2285.3 bits: 433.5 E(32554): 5.7e-121
Smith-Waterman score: 3353; 65.0% identity (82.3% similar) in 758 aa overlap (15-746:15-745)
10 20 30 40 50 60
pF1KSD MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEW
:...:::::::::::::.. .:... .: :. :.:.:::.::
CCDS56 MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD KKLRVQPVQSMKPVSGHPFLKKCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQN
:. :.:::. . ::. ..:.. : . : .: . ...::.:: :::::::::::::
CCDS56 KQRRIQPVHILTSVSSLRGTRECSVTSDLD-FPTQVIPLKTLNAVASVPIMYSWSPLQQN
70 80 90 100 110
130 140 150 160 170 180
pF1KSD FMVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELV
::::::::: ::::::::: ..: :::::::.::::::::..: : .:.: .:.:::
CCDS56 FMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDREC--G--FINDEIFVELV
120 130 140 150 160 170
190 200 210 220 230
pF1KSD DALNQYSDEEEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGNK--KSSK--KQFPNDMI
.::.::.:.. : .:: :: .: :..:.. .: .. : :. ..::.: :
CCDS56 NALGQYNDDD-----DDDDG--DDPEE-----REEKQKDLEDHRDDKESRPPRKFPSDKI
180 190 200 210 220
240 250 260 270 280 290
pF1KSD FSAIASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHT
: ::.::::..:. ...::.:.::::.. :.::::.::::::::::::::::::::::::
CCDS56 FEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHT
230 240 250 260 270 280
300 310 320 330 340 350
pF1KSD LFCRRCFKYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAM------L
:::::::::::::::::::::.::::: : .. .::: .:. ::::::.: .
CCDS56 LFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERI
290 300 310 320 330 340
360 370 380 390
pF1KSD HNPRSKCSGRRRRRHHIVSASCSNASASAVAETKEGDSDRDTGN---------------D
..: .. .:::: : :. :. . . : :.:. ::::..:. :
CCDS56 KTPPKRPGGRRRGRLPNNSSRPSTPTIN-VLESKDTDSDREAGTETGGENNDKEEEEKKD
350 360 370 380 390 400
400 410 420 430 440 450
pF1KSD WASSSSEANSRCQTPTKQKASPAPPQLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCS
.::::::::::::: :.: . :: : :::.::: :.:::. :::..:::.
CCDS56 ETSSSSEANSRCQTPIKMKPNIEPP---------ENVEWSGAEASMFRVLIGTYYDNFCA
410 420 430 440 450
460 470 480 490 500 510
pF1KSD IARLLGTKTCKQVFQFAVKES-LILKLPTDELMNPSQKKKRKHRLWAAHCRKIQLKKDNS
::::.:::::.::..: :::: .: :.... .: .:::::::::::::::::::::.:
CCDS56 IARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGS
460 470 480 490 500 510
520 530 540 550 560 570
pF1KSD STQVYNYQPCDHPDRPCDSTCPCIMTQNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPC
:..:::::::::: .::::.:::...::::::::::. .:::::::::::.:::::::::
CCDS56 SNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPC
520 530 540 550 560 570
580 590 600 610 620 630
pF1KSD YLAVRECDPDLCLTCGASEHWDCKVVSCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQ
:::::::::::::::::..::: : ::::::::::: ::::::::::::::: :::. ::
CCDS56 YLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQ
580 590 600 610 620 630
640 650 660 670 680 690
pF1KSD KNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNP
:::::::::::.::::::::::::::::: ::::::::::::::::::::::::::::::
CCDS56 KNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNP
640 650 660 670 680 690
700 710 720 730 740
pF1KSD NCYAKVVMVNGDHRIGIFAKRAIQAGEELFFDYRYSQADALKYVGIERETDVL
::::::.:::::::::::::::::.:::::::::::::::::::::::: ..
CCDS56 NCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP
700 710 720 730 740
>>CCDS5891.1 EZH2 gene_id:2146|Hs108|chr7 (751 aa)
initn: 3162 init1: 1692 opt: 2624 Z-score: 2220.4 bits: 421.5 E(32554): 2.3e-117
Smith-Waterman score: 3322; 64.5% identity (81.7% similar) in 763 aa overlap (15-746:15-750)
10 20 30 40 50 60
pF1KSD MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEW
:...:::::::::::::.. .:... .: :. :.:.:::.::
CCDS58 MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD KKLRVQPVQSMKPVSGHPFLKKCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQN
:. :.:::. . ::. ..:.. : . : .: . ...::.:: :::::::::::::
CCDS58 KQRRIQPVHILTSVSSLRGTRECSVTSDLD-FPTQVIPLKTLNAVASVPIMYSWSPLQQN
70 80 90 100 110
130 140 150 160 170 180
pF1KSD FMVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELV
::::::::: ::::::::: ..: :::::::.::::::::..: : .:.: .:.:::
CCDS58 FMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDREC--G--FINDEIFVELV
120 130 140 150 160 170
190 200 210 220 230
pF1KSD DALNQYSDEEEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGNK--KSSK--KQFPNDMI
.::.::.:.. : .:: :: .: :..:.. .: .. : :. ..::.: :
CCDS58 NALGQYNDDD-----DDDDG--DDPEE-----REEKQKDLEDHRDDKESRPPRKFPSDKI
180 190 200 210 220
240 250 260 270 280 290
pF1KSD FSAIASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHT
: ::.::::..:. ...::.:.::::.. :.::::.::::::::::::::::::::::::
CCDS58 FEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHT
230 240 250 260 270 280
300 310 320 330 340
pF1KSD LFCRRCFKYDCFLH-----PFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAM--
:::::::::::::: ::::::.::::: : .. .::: .:. ::::::.:
CCDS58 LFCRRCFKYDCFLHRKCNYSFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAAL
290 300 310 320 330 340
350 360 370 380 390
pF1KSD ----LHNPRSKCSGRRRRRHHIVSASCSNASASAVAETKEGDSDRDTGN-----------
...: .. .:::: : :. :. . . : :.:. ::::..:.
CCDS58 TAERIKTPPKRPGGRRRGRLPNNSSRPSTPTIN-VLESKDTDSDREAGTETGGENNDKEE
350 360 370 380 390 400
400 410 420 430 440 450
pF1KSD ----DWASSSSEANSRCQTPTKQKASPAPPQLCVVEAPSEPVEWTGAEESLFRVFHGTYF
: .::::::::::::: :.: . :: : :::.::: :.:::. :::.
CCDS58 EEKKDETSSSSEANSRCQTPIKMKPNIEPP---------ENVEWSGAEASMFRVLIGTYY
410 420 430 440 450
460 470 480 490 500
pF1KSD NNFCSIARLLGTKTCKQVFQFAVKES-LILKLPTDELMNPSQKKKRKHRLWAAHCRKIQL
.:::.::::.:::::.::..: :::: .: :.... .: .::::::::::::::::::
CCDS58 DNFCAIARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQL
460 470 480 490 500 510
510 520 530 540 550 560
pF1KSD KKDNSSTQVYNYQPCDHPDRPCDSTCPCIMTQNFCEKFCQCNPDCQNRFPGCRCKTQCNT
:::.::..:::::::::: .::::.:::...::::::::::. .:::::::::::.::::
CCDS58 KKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNT
520 530 540 550 560 570
570 580 590 600 610 620
pF1KSD KQCPCYLAVRECDPDLCLTCGASEHWDCKVVSCKNCSIQRGLKKHLLLAPSDVAGWGTFI
::::::::::::::::::::::..::: : ::::::::::: ::::::::::::::: ::
CCDS58 KQCPCYLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFI
580 590 600 610 620 630
630 640 650 660 670 680
pF1KSD KESVQKNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNNDFVVDATRKGNKIRFAN
:. :::::::::::::.::::::::::::::::: :::::::::::::::::::::::::
CCDS58 KDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFAN
640 650 660 670 680 690
690 700 710 720 730 740
pF1KSD HSVNPNCYAKVVMVNGDHRIGIFAKRAIQAGEELFFDYRYSQADALKYVGIERETDVL
:::::::::::.:::::::::::::::::.:::::::::::::::::::::::: ..
CCDS58 HSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP
700 710 720 730 740 750
>>CCDS56518.1 EZH2 gene_id:2146|Hs108|chr7 (737 aa)
initn: 3005 init1: 1795 opt: 2491 Z-score: 2108.4 bits: 400.8 E(32554): 4.1e-111
Smith-Waterman score: 3328; 64.9% identity (81.9% similar) in 758 aa overlap (15-746:15-736)
10 20 30 40 50 60
pF1KSD MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEW
:...:::::::::::::.. .:... .: :. :.:.:::.::
CCDS56 MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD KKLRVQPVQSMKPVSGHPFLKKCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQN
:. :.:::. .: .:.. : . : .: . ...::.:: :::::::::::::
CCDS56 KQRRIQPVH---------ILTSCSVTSDLD-FPTQVIPLKTLNAVASVPIMYSWSPLQQN
70 80 90 100 110
130 140 150 160 170 180
pF1KSD FMVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELV
::::::::: ::::::::: ..: :::::::.::::::::..: : .:.: .:.:::
CCDS56 FMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDREC--G--FINDEIFVELV
120 130 140 150 160
190 200 210 220 230
pF1KSD DALNQYSDEEEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGNK--KSSK--KQFPNDMI
.::.::.:.. : .:: :: .: :..:.. .: .. : :. ..::.: :
CCDS56 NALGQYNDDD-----DDDDG--DDPEE-----REEKQKDLEDHRDDKESRPPRKFPSDKI
170 180 190 200 210
240 250 260 270 280 290
pF1KSD FSAIASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHT
: ::.::::..:. ...::.:.::::.. :.::::.::::::::::::::::::::::::
CCDS56 FEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHT
220 230 240 250 260 270
300 310 320 330 340 350
pF1KSD LFCRRCFKYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAM------L
:::::::::::::::::::::.::::: : .. .::: .:. ::::::.: .
CCDS56 LFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERI
280 290 300 310 320 330
360 370 380 390
pF1KSD HNPRSKCSGRRRRRHHIVSASCSNASASAVAETKEGDSDRDTGN---------------D
..: .. .:::: : :. :. . . : :.:. ::::..:. :
CCDS56 KTPPKRPGGRRRGRLPNNSSRPSTPTIN-VLESKDTDSDREAGTETGGENNDKEEEEKKD
340 350 360 370 380 390
400 410 420 430 440 450
pF1KSD WASSSSEANSRCQTPTKQKASPAPPQLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCS
.::::::::::::: :.: . :: : :::.::: :.:::. :::..:::.
CCDS56 ETSSSSEANSRCQTPIKMKPNIEPP---------ENVEWSGAEASMFRVLIGTYYDNFCA
400 410 420 430 440
460 470 480 490 500 510
pF1KSD IARLLGTKTCKQVFQFAVKES-LILKLPTDELMNPSQKKKRKHRLWAAHCRKIQLKKDNS
::::.:::::.::..: :::: .: :.... .: .:::::::::::::::::::::.:
CCDS56 IARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGS
450 460 470 480 490 500
520 530 540 550 560 570
pF1KSD STQVYNYQPCDHPDRPCDSTCPCIMTQNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPC
:..:::::::::: .::::.:::...::::::::::. .:::::::::::.:::::::::
CCDS56 SNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPC
510 520 530 540 550 560
580 590 600 610 620 630
pF1KSD YLAVRECDPDLCLTCGASEHWDCKVVSCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQ
:::::::::::::::::..::: : ::::::::::: ::::::::::::::: :::. ::
CCDS56 YLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQ
570 580 590 600 610 620
640 650 660 670 680 690
pF1KSD KNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNP
:::::::::::.::::::::::::::::: ::::::::::::::::::::::::::::::
CCDS56 KNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNP
630 640 650 660 670 680
700 710 720 730 740
pF1KSD NCYAKVVMVNGDHRIGIFAKRAIQAGEELFFDYRYSQADALKYVGIERETDVL
::::::.:::::::::::::::::.:::::::::::::::::::::::: ..
CCDS56 NCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP
690 700 710 720 730
>>CCDS5892.1 EZH2 gene_id:2146|Hs108|chr7 (707 aa)
initn: 2960 init1: 1720 opt: 2354 Z-score: 1993.2 bits: 379.4 E(32554): 1.1e-104
Smith-Waterman score: 3118; 62.3% identity (78.2% similar) in 758 aa overlap (15-746:15-706)
10 20 30 40 50 60
pF1KSD MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEW
:...:::::::::::::.. .:... .: :. :.:.:::.::
CCDS58 MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD KKLRVQPVQSMKPVSGHPFLKKCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQN
:. :.:::. :. : : :. .
CCDS58 KQRRIQPVH----------------------------------------ILTSVSSLRGT
70 80
130 140 150 160 170 180
pF1KSD FMVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELV
::::::: ::::::::: ..: :::::::.::::::::..: : .:.: .:.:::
CCDS58 REVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDREC--G--FINDEIFVELV
90 100 110 120 130
190 200 210 220 230
pF1KSD DALNQYSDEEEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGNK--KSSK--KQFPNDMI
.::.::.:.. : .:: :: .: :..:.. .: .. : :. ..::.: :
CCDS58 NALGQYNDDD-----DDDDG--DDPEE-----REEKQKDLEDHRDDKESRPPRKFPSDKI
140 150 160 170 180
240 250 260 270 280 290
pF1KSD FSAIASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHT
: ::.::::..:. ...::.:.::::.. :.::::.::::::::::::::::::::::::
CCDS58 FEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHT
190 200 210 220 230 240
300 310 320 330 340 350
pF1KSD LFCRRCFKYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAM------L
:::::::::::::::::::::.::::: : .. .::: .:. ::::::.: .
CCDS58 LFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERI
250 260 270 280 290 300
360 370 380 390
pF1KSD HNPRSKCSGRRRRRHHIVSASCSNASASAVAETKEGDSDRDTGN---------------D
..: .. .:::: : :. :. . . : :.:. ::::..:. :
CCDS58 KTPPKRPGGRRRGRLPNNSSRPSTPTIN-VLESKDTDSDREAGTETGGENNDKEEEEKKD
310 320 330 340 350 360
400 410 420 430 440 450
pF1KSD WASSSSEANSRCQTPTKQKASPAPPQLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCS
.::::::::::::: :.: . :: : :::.::: :.:::. :::..:::.
CCDS58 ETSSSSEANSRCQTPIKMKPNIEPP---------ENVEWSGAEASMFRVLIGTYYDNFCA
370 380 390 400 410
460 470 480 490 500 510
pF1KSD IARLLGTKTCKQVFQFAVKES-LILKLPTDELMNPSQKKKRKHRLWAAHCRKIQLKKDNS
::::.:::::.::..: :::: .: :.... .: .:::::::::::::::::::::.:
CCDS58 IARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGS
420 430 440 450 460 470
520 530 540 550 560 570
pF1KSD STQVYNYQPCDHPDRPCDSTCPCIMTQNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPC
:..:::::::::: .::::.:::...::::::::::. .:::::::::::.:::::::::
CCDS58 SNHVYNYQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPC
480 490 500 510 520 530
580 590 600 610 620 630
pF1KSD YLAVRECDPDLCLTCGASEHWDCKVVSCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQ
:::::::::::::::::..::: : ::::::::::: ::::::::::::::: :::. ::
CCDS58 YLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQ
540 550 560 570 580 590
640 650 660 670 680 690
pF1KSD KNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNP
:::::::::::.::::::::::::::::: ::::::::::::::::::::::::::::::
CCDS58 KNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNP
600 610 620 630 640 650
700 710 720 730 740
pF1KSD NCYAKVVMVNGDHRIGIFAKRAIQAGEELFFDYRYSQADALKYVGIERETDVL
::::::.:::::::::::::::::.:::::::::::::::::::::::: ..
CCDS58 NCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP
660 670 680 690 700
>>CCDS56517.1 EZH2 gene_id:2146|Hs108|chr7 (695 aa)
initn: 2811 init1: 1262 opt: 1262 Z-score: 1073.0 bits: 209.1 E(32554): 1.9e-53
Smith-Waterman score: 2946; 60.8% identity (76.5% similar) in 758 aa overlap (15-746:15-694)
10 20 30 40 50 60
pF1KSD MEIPNPPTSKCITYWKRKVKSEYMRLRQLKRLQANMGAKALYVANFAKVQEKTQILNEEW
:...:::::::::::::.. .:... .: :. :.:.:::.::
CCDS56 MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD KKLRVQPVQSMKPVSGHPFLKKCTIESIFPGFASQHMLMRSLNTVALVPIMYSWSPLQQN
:. :.:::. .: .:.. : . : .: . ...::.:: :::::::::::::
CCDS56 KQRRIQPVH---------ILTSCSVTSDLD-FPTQVIPLKTLNAVASVPIMYSWSPLQQN
70 80 90 100 110
130 140 150 160 170 180
pF1KSD FMVEDETVLCNIPYMGDEVKEEDETFIEELINNYDGKVHGEEEMIPGSVLISDAVFLELV
::::::::: ::::::::: ..: :::::::.::::::::..: : .:.: .:.:::
CCDS56 FMVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDREC--G--FINDEIFVELV
120 130 140 150 160
190 200 210 220 230
pF1KSD DALNQYSDEEEEGHNDTSDGKQDDSKEDLPVTRKRKRHAIEGNK--KSSK--KQFPNDMI
.::.::.:.. : .:: :: .: :..:.. .: .. : :. ..::.: :
CCDS56 NALGQYNDDD-----DDDDG--DDPEE-----REEKQKDLEDHRDDKESRPPRKFPSDKI
170 180 190 200 210
240 250 260 270 280 290
pF1KSD FSAIASMFPENGVPDDMKERYRELTEMSDPNALPPQCTPNIDGPNAKSVQREQSLHSFHT
: ::.::::..:. ...::.:.::::.. :.::::.::::::::::::::::::::::::
CCDS56 FEAISSMFPDKGTAEELKEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHT
220 230 240 250 260 270
300 310 320 330 340 350
pF1KSD LFCRRCFKYDCFLHPFHATPNVYKRKNKEIKIEPEPCGTDCFLLLEGAKEYAM------L
:::::::::::::::::::::.::::: : .. .::: .:. ::::::.: .
CCDS56 LFCRRCFKYDCFLHPFHATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERI
280 290 300 310 320 330
360 370 380 390
pF1KSD HNPRSKCSGRRRRRHHIVSASCSNASASAVAETKEGDSDRDTGN---------------D
..: .. .:::: : :. :. . . : :.:. ::::..:. :
CCDS56 KTPPKRPGGRRRGRLPNNSSRPSTPTIN-VLESKDTDSDREAGTETGGENNDKEEEEKKD
340 350 360 370 380 390
400 410 420 430 440 450
pF1KSD WASSSSEANSRCQTPTKQKASPAPPQLCVVEAPSEPVEWTGAEESLFRVFHGTYFNNFCS
.::::::::::::: :.: . :: : :::.::: :.:::. :::..:::.
CCDS56 ETSSSSEANSRCQTPIKMKPNIEPP---------ENVEWSGAEASMFRVLIGTYYDNFCA
400 410 420 430 440
460 470 480 490 500 510
pF1KSD IARLLGTKTCKQVFQFAVKES-LILKLPTDELMNPSQKKKRKHRLWAAHCRKIQLKKDNS
::::.:::::.::..: :::: .: :.... .: .::::::::::::::::::::
CCDS56 IARLIGTKTCRQVYEFRVKESSIIAPAPAEDVDTPPRKKKRKHRLWAAHCRKIQLKKG--
450 460 470 480 490 500
520 530 540 550 560 570
pF1KSD STQVYNYQPCDHPDRPCDSTCPCIMTQNFCEKFCQCNPDCQNRFPGCRCKTQCNTKQCPC
::::::::::.:::::::::
CCDS56 ----------------------------------------QNRFPGCRCKAQCNTKQCPC
510 520
580 590 600 610 620 630
pF1KSD YLAVRECDPDLCLTCGASEHWDCKVVSCKNCSIQRGLKKHLLLAPSDVAGWGTFIKESVQ
:::::::::::::::::..::: : ::::::::::: ::::::::::::::: :::. ::
CCDS56 YLAVRECDPDLCLTCGAADHWDSKNVSCKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQ
530 540 550 560 570 580
640 650 660 670 680 690
pF1KSD KNEFISEYCGELISQDEADRRGKVYDKYMSSFLFNLNNDFVVDATRKGNKIRFANHSVNP
:::::::::::.::::::::::::::::: ::::::::::::::::::::::::::::::
CCDS56 KNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFANHSVNP
590 600 610 620 630 640
700 710 720 730 740
pF1KSD NCYAKVVMVNGDHRIGIFAKRAIQAGEELFFDYRYSQADALKYVGIERETDVL
::::::.:::::::::::::::::.:::::::::::::::::::::::: ..
CCDS56 NCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRYSQADALKYVGIEREMEIP
650 660 670 680 690
747 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 01:35:28 2016 done: Thu Nov 3 01:35:29 2016
Total Scan time: 2.740 Total Display time: 0.150
Function used was FASTA [36.3.4 Apr, 2011]