Result of FASTA (omim) for
pFN21ASDA0319
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA0319, 1072 aa
1>>>pF1KSDA0319 1072 - 1072 aa - 1072 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.8089+/-0.000435; mu= -5.8267+/- 0.027
mean_var=226.1842+/-46.339, 0's: 0 Z-trim(116.7): 55 B-trim: 0 in 0/59
Lambda= 0.085279
statistics sampled from 27984 (28034) to 27984 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.672), E-opt: 0.2 (0.329), width: 16
Scan time: 13.490
The best scores are: opt bits E(85289)
NP_001161847 (OMIM: 600202,609269) dyslexia-associ (1072) 7106 888.3 0
XP_011513327 (OMIM: 600202,609269) PREDICTED: dysl (1072) 7106 888.3 0
NP_055624 (OMIM: 600202,609269) dyslexia-associate (1072) 7106 888.3 0
NP_001161846 (OMIM: 600202,609269) dyslexia-associ (1063) 6993 874.4 0
XP_016867030 (OMIM: 600202,609269) PREDICTED: dysl (1063) 6993 874.4 0
XP_016867034 (OMIM: 600202,609269) PREDICTED: dysl (1027) 6821 853.2 0
XP_011513328 (OMIM: 600202,609269) PREDICTED: dysl (1027) 6821 853.2 0
NP_001161848 (OMIM: 600202,609269) dyslexia-associ (1027) 6821 853.2 0
XP_016867031 (OMIM: 600202,609269) PREDICTED: dysl (1047) 6720 840.8 0
XP_016867035 (OMIM: 600202,609269) PREDICTED: dysl ( 986) 6301 789.2 0
XP_016867039 (OMIM: 600202,609269) PREDICTED: dysl ( 978) 6296 788.6 0
XP_016867036 (OMIM: 600202,609269) PREDICTED: dysl ( 978) 6296 788.6 0
XP_016867038 (OMIM: 600202,609269) PREDICTED: dysl ( 978) 6296 788.6 0
XP_016867037 (OMIM: 600202,609269) PREDICTED: dysl ( 978) 6296 788.6 0
NP_001161849 (OMIM: 600202,609269) dyslexia-associ (1011) 6294 788.4 0
XP_016867042 (OMIM: 600202,609269) PREDICTED: dysl ( 920) 6033 756.2 1.9e-217
XP_016867041 (OMIM: 600202,609269) PREDICTED: dysl ( 920) 6033 756.2 1.9e-217
XP_016867040 (OMIM: 600202,609269) PREDICTED: dysl ( 937) 5967 748.1 5.3e-215
XP_016867032 (OMIM: 600202,609269) PREDICTED: dysl (1039) 4729 595.8 4.1e-169
XP_016867033 (OMIM: 600202,609269) PREDICTED: dysl (1039) 4729 595.8 4.1e-169
NP_001239257 (OMIM: 600202,609269) dyslexia-associ ( 483) 3195 407.0 1.3e-112
NP_079150 (OMIM: 613535) dyslexia-associated prote (1049) 2959 378.1 1.5e-103
XP_011540481 (OMIM: 613535) PREDICTED: dyslexia-as (1049) 2959 378.1 1.5e-103
XP_006710970 (OMIM: 613535) PREDICTED: dyslexia-as (1049) 2959 378.1 1.5e-103
XP_006710972 (OMIM: 613535) PREDICTED: dyslexia-as (1049) 2959 378.1 1.5e-103
XP_016857855 (OMIM: 613535) PREDICTED: dyslexia-as (1054) 2945 376.3 5e-103
XP_016857858 (OMIM: 613535) PREDICTED: dyslexia-as (1054) 2945 376.3 5e-103
XP_016857857 (OMIM: 613535) PREDICTED: dyslexia-as (1054) 2945 376.3 5e-103
XP_016857856 (OMIM: 613535) PREDICTED: dyslexia-as (1054) 2945 376.3 5e-103
XP_006710973 (OMIM: 613535) PREDICTED: dyslexia-as ( 691) 2708 347.1 2e-94
XP_016857865 (OMIM: 613535) PREDICTED: dyslexia-as ( 691) 2708 347.1 2e-94
XP_016857864 (OMIM: 613535) PREDICTED: dyslexia-as ( 696) 2694 345.4 6.7e-94
XP_016857863 (OMIM: 613535) PREDICTED: dyslexia-as ( 696) 2694 345.4 6.7e-94
XP_011540482 (OMIM: 613535) PREDICTED: dyslexia-as ( 950) 2628 337.3 2.5e-91
XP_016857861 (OMIM: 613535) PREDICTED: dyslexia-as ( 950) 2628 337.3 2.5e-91
XP_016857859 (OMIM: 613535) PREDICTED: dyslexia-as ( 955) 2614 335.6 8.2e-91
XP_016857860 (OMIM: 613535) PREDICTED: dyslexia-as ( 955) 2614 335.6 8.2e-91
XP_016857866 (OMIM: 613535) PREDICTED: dyslexia-as ( 592) 2377 306.4 3.2e-82
XP_016857862 (OMIM: 613535) PREDICTED: dyslexia-as ( 853) 2249 290.7 2.4e-77
XP_016857867 (OMIM: 613535) PREDICTED: dyslexia-as ( 491) 1775 232.3 5.3e-60
>>NP_001161847 (OMIM: 600202,609269) dyslexia-associated (1072 aa)
initn: 7106 init1: 7106 opt: 7106 Z-score: 4737.3 bits: 888.3 E(85289): 0
Smith-Waterman score: 7106; 99.8% identity (99.9% similar) in 1072 aa overlap (1-1072:1-1072)
10 20 30 40 50 60
pF1KSD MAPPTGVLSSLLLLVTIAGCARKQCSEGRTYSNAVISPNLETTRIMRVSHTFPVVDCTAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAPPTGVLSSLLLLVTIAGCARKQCSEGRTYSNAVISPNLETTRIMRVSHTFPVVDCTAA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD CCDLSSCDLAWWFEGRCYLVSCPHKENCEPKKMGPIRSYLTFVLRPVQRPAQLLDYGDMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CCDLSSCDLAWWFEGRCYLVSCPHKENCEPKKMGPIRSYLTFVLRPVQRPAQLLDYGDMM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD LNRGSPSGIWGDSPEDIRKDLPFLGKDWGLEEMSEYADDYRELEKDLLQPSGKQEPRGSA
::::::::::::::::::::: ::::::::::::::.:::::::::::::::::::::::
NP_001 LNRGSPSGIWGDSPEDIRKDLTFLGKDWGLEEMSEYSDDYRELEKDLLQPSGKQEPRGSA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD EYTDWGLLPGSEGAFNSSVGDSPAVPAETQQDPELHYLNESASTPAPKLPERSVLLPLPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EYTDWGLLPGSEGAFNSSVGDSPAVPAETQQDPELHYLNESASTPAPKLPERSVLLPLPT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD TPSSGEVLEKEKASQLQEQSSNSSGKEVLMPSHSLPPASLELSSVTVEKSPVLTVTPGST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPSSGEVLEKEKASQLQEQSSNSSGKEVLMPSHSLPPASLELSSVTVEKSPVLTVTPGST
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD EHSIPTPPTSAAPSESTPSELPISPTTAPRTVKELTVSAGDNLIITLPDNEVELKAFVAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EHSIPTPPTSAAPSESTPSELPISPTTAPRTVKELTVSAGDNLIITLPDNEVELKAFVAP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD APPVETTYNYEWNLISHPTDYQGEIKQGHKQTLNLSQLSVGLYVFKVTVSSENAFGEGFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APPVETTYNYEWNLISHPTDYQGEIKQGHKQTLNLSQLSVGLYVFKVTVSSENAFGEGFV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD NVTVKPARRVNLPPVAVVSPQLQELTLPLTSALIDGSQSTDDTEIVSYHWEEINGPFIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NVTVKPARRVNLPPVAVVSPQLQELTLPLTSALIDGSQSTDDTEIVSYHWEEINGPFIEE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD KTSVDSPVLRLSNLDPGNYSFRLTVTDSDGATNSTTAALIVNNAVDYPPVANAGPNHTIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KTSVDSPVLRLSNLDPGNYSFRLTVTDSDGATNSTTAALIVNNAVDYPPVANAGPNHTIT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD LPQNSITLNGNQSSDDHQIVLYEWSLGPGSEGKHVVMQGVQTPYLHLSAMQEGDYTFQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPQNSITLNGNQSSDDHQIVLYEWSLGPGSEGKHVVMQGVQTPYLHLSAMQEGDYTFQLK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD VTDSSRQQSTAVVTVIVQPENNRPPVAVAGPDKELIFPVESATLDGSSSSDDHGIVFYHW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTDSSRQQSTAVVTVIVQPENNRPPVAVAGPDKELIFPVESATLDGSSSSDDHGIVFYHW
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD EHVRGPSAVEMENIDKAIATVTGLQVGTYHFRLTVKDQQGLSSTSTLTVAVKKENNSPPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EHVRGPSAVEMENIDKAIATVTGLQVGTYHFRLTVKDQQGLSSTSTLTVAVKKENNSPPR
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD ARAGGRHVLVLPNNSITLDGSRSTDDQRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARAGGRHVLVLPNNSITLDGSRSTDDQRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD LVEGVYTFHLRVTDSQGASDTDTATVEVQPDPRKSGLVELTLQVGVGQLTEQRKDTLVRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVEGVYTFHLRVTDSQGASDTDTATVEVQPDPRKSGLVELTLQVGVGQLTEQRKDTLVRQ
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD LAVLLNVLDSDIKVQKIRAHSDLSTVIVFYVQSRPPFKVLKAAEVARNLHMRLSKEKADF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAVLLNVLDSDIKVQKIRAHSDLSTVIVFYVQSRPPFKVLKAAEVARNLHMRLSKEKADF
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD LLFKVLRVDTAGCLLKCSGHGHCDPLTKRCICSHLWMENLIQRYIWDGESNCEWSIFYVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLFKVLRVDTAGCLLKCSGHGHCDPLTKRCICSHLWMENLIQRYIWDGESNCEWSIFYVT
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD VLAFTLIVLTGGFTWLCICCCKRQKRTKIRKKTKYTILDNMDEQERMELRPKYGIKHRST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLAFTLIVLTGGFTWLCICCCKRQKRTKIRKKTKYTILDNMDEQERMELRPKYGIKHRST
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070
pF1KSD EHNSSLMVSESEFDSDQDTIFSREKMERGNPKVSMNGSIRNGASFSYCSKDR
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EHNSSLMVSESEFDSDQDTIFSREKMERGNPKVSMNGSIRNGASFSYCSKDR
1030 1040 1050 1060 1070
>>XP_011513327 (OMIM: 600202,609269) PREDICTED: dyslexia (1072 aa)
initn: 7106 init1: 7106 opt: 7106 Z-score: 4737.3 bits: 888.3 E(85289): 0
Smith-Waterman score: 7106; 99.8% identity (99.9% similar) in 1072 aa overlap (1-1072:1-1072)
10 20 30 40 50 60
pF1KSD MAPPTGVLSSLLLLVTIAGCARKQCSEGRTYSNAVISPNLETTRIMRVSHTFPVVDCTAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAPPTGVLSSLLLLVTIAGCARKQCSEGRTYSNAVISPNLETTRIMRVSHTFPVVDCTAA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD CCDLSSCDLAWWFEGRCYLVSCPHKENCEPKKMGPIRSYLTFVLRPVQRPAQLLDYGDMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CCDLSSCDLAWWFEGRCYLVSCPHKENCEPKKMGPIRSYLTFVLRPVQRPAQLLDYGDMM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD LNRGSPSGIWGDSPEDIRKDLPFLGKDWGLEEMSEYADDYRELEKDLLQPSGKQEPRGSA
::::::::::::::::::::: ::::::::::::::.:::::::::::::::::::::::
XP_011 LNRGSPSGIWGDSPEDIRKDLTFLGKDWGLEEMSEYSDDYRELEKDLLQPSGKQEPRGSA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD EYTDWGLLPGSEGAFNSSVGDSPAVPAETQQDPELHYLNESASTPAPKLPERSVLLPLPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EYTDWGLLPGSEGAFNSSVGDSPAVPAETQQDPELHYLNESASTPAPKLPERSVLLPLPT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD TPSSGEVLEKEKASQLQEQSSNSSGKEVLMPSHSLPPASLELSSVTVEKSPVLTVTPGST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPSSGEVLEKEKASQLQEQSSNSSGKEVLMPSHSLPPASLELSSVTVEKSPVLTVTPGST
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD EHSIPTPPTSAAPSESTPSELPISPTTAPRTVKELTVSAGDNLIITLPDNEVELKAFVAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EHSIPTPPTSAAPSESTPSELPISPTTAPRTVKELTVSAGDNLIITLPDNEVELKAFVAP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD APPVETTYNYEWNLISHPTDYQGEIKQGHKQTLNLSQLSVGLYVFKVTVSSENAFGEGFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APPVETTYNYEWNLISHPTDYQGEIKQGHKQTLNLSQLSVGLYVFKVTVSSENAFGEGFV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD NVTVKPARRVNLPPVAVVSPQLQELTLPLTSALIDGSQSTDDTEIVSYHWEEINGPFIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVTVKPARRVNLPPVAVVSPQLQELTLPLTSALIDGSQSTDDTEIVSYHWEEINGPFIEE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD KTSVDSPVLRLSNLDPGNYSFRLTVTDSDGATNSTTAALIVNNAVDYPPVANAGPNHTIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KTSVDSPVLRLSNLDPGNYSFRLTVTDSDGATNSTTAALIVNNAVDYPPVANAGPNHTIT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD LPQNSITLNGNQSSDDHQIVLYEWSLGPGSEGKHVVMQGVQTPYLHLSAMQEGDYTFQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPQNSITLNGNQSSDDHQIVLYEWSLGPGSEGKHVVMQGVQTPYLHLSAMQEGDYTFQLK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD VTDSSRQQSTAVVTVIVQPENNRPPVAVAGPDKELIFPVESATLDGSSSSDDHGIVFYHW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTDSSRQQSTAVVTVIVQPENNRPPVAVAGPDKELIFPVESATLDGSSSSDDHGIVFYHW
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD EHVRGPSAVEMENIDKAIATVTGLQVGTYHFRLTVKDQQGLSSTSTLTVAVKKENNSPPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EHVRGPSAVEMENIDKAIATVTGLQVGTYHFRLTVKDQQGLSSTSTLTVAVKKENNSPPR
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD ARAGGRHVLVLPNNSITLDGSRSTDDQRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ARAGGRHVLVLPNNSITLDGSRSTDDQRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD LVEGVYTFHLRVTDSQGASDTDTATVEVQPDPRKSGLVELTLQVGVGQLTEQRKDTLVRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVEGVYTFHLRVTDSQGASDTDTATVEVQPDPRKSGLVELTLQVGVGQLTEQRKDTLVRQ
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD LAVLLNVLDSDIKVQKIRAHSDLSTVIVFYVQSRPPFKVLKAAEVARNLHMRLSKEKADF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAVLLNVLDSDIKVQKIRAHSDLSTVIVFYVQSRPPFKVLKAAEVARNLHMRLSKEKADF
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD LLFKVLRVDTAGCLLKCSGHGHCDPLTKRCICSHLWMENLIQRYIWDGESNCEWSIFYVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLFKVLRVDTAGCLLKCSGHGHCDPLTKRCICSHLWMENLIQRYIWDGESNCEWSIFYVT
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD VLAFTLIVLTGGFTWLCICCCKRQKRTKIRKKTKYTILDNMDEQERMELRPKYGIKHRST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLAFTLIVLTGGFTWLCICCCKRQKRTKIRKKTKYTILDNMDEQERMELRPKYGIKHRST
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070
pF1KSD EHNSSLMVSESEFDSDQDTIFSREKMERGNPKVSMNGSIRNGASFSYCSKDR
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EHNSSLMVSESEFDSDQDTIFSREKMERGNPKVSMNGSIRNGASFSYCSKDR
1030 1040 1050 1060 1070
>>NP_055624 (OMIM: 600202,609269) dyslexia-associated pr (1072 aa)
initn: 7106 init1: 7106 opt: 7106 Z-score: 4737.3 bits: 888.3 E(85289): 0
Smith-Waterman score: 7106; 99.8% identity (99.9% similar) in 1072 aa overlap (1-1072:1-1072)
10 20 30 40 50 60
pF1KSD MAPPTGVLSSLLLLVTIAGCARKQCSEGRTYSNAVISPNLETTRIMRVSHTFPVVDCTAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MAPPTGVLSSLLLLVTIAGCARKQCSEGRTYSNAVISPNLETTRIMRVSHTFPVVDCTAA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD CCDLSSCDLAWWFEGRCYLVSCPHKENCEPKKMGPIRSYLTFVLRPVQRPAQLLDYGDMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 CCDLSSCDLAWWFEGRCYLVSCPHKENCEPKKMGPIRSYLTFVLRPVQRPAQLLDYGDMM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD LNRGSPSGIWGDSPEDIRKDLPFLGKDWGLEEMSEYADDYRELEKDLLQPSGKQEPRGSA
::::::::::::::::::::: ::::::::::::::.:::::::::::::::::::::::
NP_055 LNRGSPSGIWGDSPEDIRKDLTFLGKDWGLEEMSEYSDDYRELEKDLLQPSGKQEPRGSA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD EYTDWGLLPGSEGAFNSSVGDSPAVPAETQQDPELHYLNESASTPAPKLPERSVLLPLPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EYTDWGLLPGSEGAFNSSVGDSPAVPAETQQDPELHYLNESASTPAPKLPERSVLLPLPT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD TPSSGEVLEKEKASQLQEQSSNSSGKEVLMPSHSLPPASLELSSVTVEKSPVLTVTPGST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 TPSSGEVLEKEKASQLQEQSSNSSGKEVLMPSHSLPPASLELSSVTVEKSPVLTVTPGST
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD EHSIPTPPTSAAPSESTPSELPISPTTAPRTVKELTVSAGDNLIITLPDNEVELKAFVAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EHSIPTPPTSAAPSESTPSELPISPTTAPRTVKELTVSAGDNLIITLPDNEVELKAFVAP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD APPVETTYNYEWNLISHPTDYQGEIKQGHKQTLNLSQLSVGLYVFKVTVSSENAFGEGFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 APPVETTYNYEWNLISHPTDYQGEIKQGHKQTLNLSQLSVGLYVFKVTVSSENAFGEGFV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD NVTVKPARRVNLPPVAVVSPQLQELTLPLTSALIDGSQSTDDTEIVSYHWEEINGPFIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NVTVKPARRVNLPPVAVVSPQLQELTLPLTSALIDGSQSTDDTEIVSYHWEEINGPFIEE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD KTSVDSPVLRLSNLDPGNYSFRLTVTDSDGATNSTTAALIVNNAVDYPPVANAGPNHTIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 KTSVDSPVLRLSNLDPGNYSFRLTVTDSDGATNSTTAALIVNNAVDYPPVANAGPNHTIT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD LPQNSITLNGNQSSDDHQIVLYEWSLGPGSEGKHVVMQGVQTPYLHLSAMQEGDYTFQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LPQNSITLNGNQSSDDHQIVLYEWSLGPGSEGKHVVMQGVQTPYLHLSAMQEGDYTFQLK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD VTDSSRQQSTAVVTVIVQPENNRPPVAVAGPDKELIFPVESATLDGSSSSDDHGIVFYHW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VTDSSRQQSTAVVTVIVQPENNRPPVAVAGPDKELIFPVESATLDGSSSSDDHGIVFYHW
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD EHVRGPSAVEMENIDKAIATVTGLQVGTYHFRLTVKDQQGLSSTSTLTVAVKKENNSPPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EHVRGPSAVEMENIDKAIATVTGLQVGTYHFRLTVKDQQGLSSTSTLTVAVKKENNSPPR
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD ARAGGRHVLVLPNNSITLDGSRSTDDQRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ARAGGRHVLVLPNNSITLDGSRSTDDQRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD LVEGVYTFHLRVTDSQGASDTDTATVEVQPDPRKSGLVELTLQVGVGQLTEQRKDTLVRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LVEGVYTFHLRVTDSQGASDTDTATVEVQPDPRKSGLVELTLQVGVGQLTEQRKDTLVRQ
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD LAVLLNVLDSDIKVQKIRAHSDLSTVIVFYVQSRPPFKVLKAAEVARNLHMRLSKEKADF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LAVLLNVLDSDIKVQKIRAHSDLSTVIVFYVQSRPPFKVLKAAEVARNLHMRLSKEKADF
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD LLFKVLRVDTAGCLLKCSGHGHCDPLTKRCICSHLWMENLIQRYIWDGESNCEWSIFYVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LLFKVLRVDTAGCLLKCSGHGHCDPLTKRCICSHLWMENLIQRYIWDGESNCEWSIFYVT
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD VLAFTLIVLTGGFTWLCICCCKRQKRTKIRKKTKYTILDNMDEQERMELRPKYGIKHRST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VLAFTLIVLTGGFTWLCICCCKRQKRTKIRKKTKYTILDNMDEQERMELRPKYGIKHRST
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070
pF1KSD EHNSSLMVSESEFDSDQDTIFSREKMERGNPKVSMNGSIRNGASFSYCSKDR
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EHNSSLMVSESEFDSDQDTIFSREKMERGNPKVSMNGSIRNGASFSYCSKDR
1030 1040 1050 1060 1070
>>NP_001161846 (OMIM: 600202,609269) dyslexia-associated (1063 aa)
initn: 6993 init1: 6993 opt: 6993 Z-score: 4662.2 bits: 874.4 E(85289): 0
Smith-Waterman score: 6993; 99.8% identity (99.9% similar) in 1053 aa overlap (20-1072:11-1063)
10 20 30 40 50 60
pF1KSD MAPPTGVLSSLLLLVTIAGCARKQCSEGRTYSNAVISPNLETTRIMRVSHTFPVVDCTAA
:::::::::::::::::::::::::::::::::::::::::
NP_001 MTRLGWPSPCCARKQCSEGRTYSNAVISPNLETTRIMRVSHTFPVVDCTAA
10 20 30 40 50
70 80 90 100 110 120
pF1KSD CCDLSSCDLAWWFEGRCYLVSCPHKENCEPKKMGPIRSYLTFVLRPVQRPAQLLDYGDMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CCDLSSCDLAWWFEGRCYLVSCPHKENCEPKKMGPIRSYLTFVLRPVQRPAQLLDYGDMM
60 70 80 90 100 110
130 140 150 160 170 180
pF1KSD LNRGSPSGIWGDSPEDIRKDLPFLGKDWGLEEMSEYADDYRELEKDLLQPSGKQEPRGSA
::::::::::::::::::::: ::::::::::::::.:::::::::::::::::::::::
NP_001 LNRGSPSGIWGDSPEDIRKDLTFLGKDWGLEEMSEYSDDYRELEKDLLQPSGKQEPRGSA
120 130 140 150 160 170
190 200 210 220 230 240
pF1KSD EYTDWGLLPGSEGAFNSSVGDSPAVPAETQQDPELHYLNESASTPAPKLPERSVLLPLPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EYTDWGLLPGSEGAFNSSVGDSPAVPAETQQDPELHYLNESASTPAPKLPERSVLLPLPT
180 190 200 210 220 230
250 260 270 280 290 300
pF1KSD TPSSGEVLEKEKASQLQEQSSNSSGKEVLMPSHSLPPASLELSSVTVEKSPVLTVTPGST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPSSGEVLEKEKASQLQEQSSNSSGKEVLMPSHSLPPASLELSSVTVEKSPVLTVTPGST
240 250 260 270 280 290
310 320 330 340 350 360
pF1KSD EHSIPTPPTSAAPSESTPSELPISPTTAPRTVKELTVSAGDNLIITLPDNEVELKAFVAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EHSIPTPPTSAAPSESTPSELPISPTTAPRTVKELTVSAGDNLIITLPDNEVELKAFVAP
300 310 320 330 340 350
370 380 390 400 410 420
pF1KSD APPVETTYNYEWNLISHPTDYQGEIKQGHKQTLNLSQLSVGLYVFKVTVSSENAFGEGFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APPVETTYNYEWNLISHPTDYQGEIKQGHKQTLNLSQLSVGLYVFKVTVSSENAFGEGFV
360 370 380 390 400 410
430 440 450 460 470 480
pF1KSD NVTVKPARRVNLPPVAVVSPQLQELTLPLTSALIDGSQSTDDTEIVSYHWEEINGPFIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NVTVKPARRVNLPPVAVVSPQLQELTLPLTSALIDGSQSTDDTEIVSYHWEEINGPFIEE
420 430 440 450 460 470
490 500 510 520 530 540
pF1KSD KTSVDSPVLRLSNLDPGNYSFRLTVTDSDGATNSTTAALIVNNAVDYPPVANAGPNHTIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KTSVDSPVLRLSNLDPGNYSFRLTVTDSDGATNSTTAALIVNNAVDYPPVANAGPNHTIT
480 490 500 510 520 530
550 560 570 580 590 600
pF1KSD LPQNSITLNGNQSSDDHQIVLYEWSLGPGSEGKHVVMQGVQTPYLHLSAMQEGDYTFQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPQNSITLNGNQSSDDHQIVLYEWSLGPGSEGKHVVMQGVQTPYLHLSAMQEGDYTFQLK
540 550 560 570 580 590
610 620 630 640 650 660
pF1KSD VTDSSRQQSTAVVTVIVQPENNRPPVAVAGPDKELIFPVESATLDGSSSSDDHGIVFYHW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTDSSRQQSTAVVTVIVQPENNRPPVAVAGPDKELIFPVESATLDGSSSSDDHGIVFYHW
600 610 620 630 640 650
670 680 690 700 710 720
pF1KSD EHVRGPSAVEMENIDKAIATVTGLQVGTYHFRLTVKDQQGLSSTSTLTVAVKKENNSPPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EHVRGPSAVEMENIDKAIATVTGLQVGTYHFRLTVKDQQGLSSTSTLTVAVKKENNSPPR
660 670 680 690 700 710
730 740 750 760 770 780
pF1KSD ARAGGRHVLVLPNNSITLDGSRSTDDQRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARAGGRHVLVLPNNSITLDGSRSTDDQRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTN
720 730 740 750 760 770
790 800 810 820 830 840
pF1KSD LVEGVYTFHLRVTDSQGASDTDTATVEVQPDPRKSGLVELTLQVGVGQLTEQRKDTLVRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVEGVYTFHLRVTDSQGASDTDTATVEVQPDPRKSGLVELTLQVGVGQLTEQRKDTLVRQ
780 790 800 810 820 830
850 860 870 880 890 900
pF1KSD LAVLLNVLDSDIKVQKIRAHSDLSTVIVFYVQSRPPFKVLKAAEVARNLHMRLSKEKADF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAVLLNVLDSDIKVQKIRAHSDLSTVIVFYVQSRPPFKVLKAAEVARNLHMRLSKEKADF
840 850 860 870 880 890
910 920 930 940 950 960
pF1KSD LLFKVLRVDTAGCLLKCSGHGHCDPLTKRCICSHLWMENLIQRYIWDGESNCEWSIFYVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLFKVLRVDTAGCLLKCSGHGHCDPLTKRCICSHLWMENLIQRYIWDGESNCEWSIFYVT
900 910 920 930 940 950
970 980 990 1000 1010 1020
pF1KSD VLAFTLIVLTGGFTWLCICCCKRQKRTKIRKKTKYTILDNMDEQERMELRPKYGIKHRST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLAFTLIVLTGGFTWLCICCCKRQKRTKIRKKTKYTILDNMDEQERMELRPKYGIKHRST
960 970 980 990 1000 1010
1030 1040 1050 1060 1070
pF1KSD EHNSSLMVSESEFDSDQDTIFSREKMERGNPKVSMNGSIRNGASFSYCSKDR
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EHNSSLMVSESEFDSDQDTIFSREKMERGNPKVSMNGSIRNGASFSYCSKDR
1020 1030 1040 1050 1060
>>XP_016867030 (OMIM: 600202,609269) PREDICTED: dyslexia (1063 aa)
initn: 6993 init1: 6993 opt: 6993 Z-score: 4662.2 bits: 874.4 E(85289): 0
Smith-Waterman score: 6993; 99.8% identity (99.9% similar) in 1053 aa overlap (20-1072:11-1063)
10 20 30 40 50 60
pF1KSD MAPPTGVLSSLLLLVTIAGCARKQCSEGRTYSNAVISPNLETTRIMRVSHTFPVVDCTAA
:::::::::::::::::::::::::::::::::::::::::
XP_016 MTRLGWPSPCCARKQCSEGRTYSNAVISPNLETTRIMRVSHTFPVVDCTAA
10 20 30 40 50
70 80 90 100 110 120
pF1KSD CCDLSSCDLAWWFEGRCYLVSCPHKENCEPKKMGPIRSYLTFVLRPVQRPAQLLDYGDMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CCDLSSCDLAWWFEGRCYLVSCPHKENCEPKKMGPIRSYLTFVLRPVQRPAQLLDYGDMM
60 70 80 90 100 110
130 140 150 160 170 180
pF1KSD LNRGSPSGIWGDSPEDIRKDLPFLGKDWGLEEMSEYADDYRELEKDLLQPSGKQEPRGSA
::::::::::::::::::::: ::::::::::::::.:::::::::::::::::::::::
XP_016 LNRGSPSGIWGDSPEDIRKDLTFLGKDWGLEEMSEYSDDYRELEKDLLQPSGKQEPRGSA
120 130 140 150 160 170
190 200 210 220 230 240
pF1KSD EYTDWGLLPGSEGAFNSSVGDSPAVPAETQQDPELHYLNESASTPAPKLPERSVLLPLPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EYTDWGLLPGSEGAFNSSVGDSPAVPAETQQDPELHYLNESASTPAPKLPERSVLLPLPT
180 190 200 210 220 230
250 260 270 280 290 300
pF1KSD TPSSGEVLEKEKASQLQEQSSNSSGKEVLMPSHSLPPASLELSSVTVEKSPVLTVTPGST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPSSGEVLEKEKASQLQEQSSNSSGKEVLMPSHSLPPASLELSSVTVEKSPVLTVTPGST
240 250 260 270 280 290
310 320 330 340 350 360
pF1KSD EHSIPTPPTSAAPSESTPSELPISPTTAPRTVKELTVSAGDNLIITLPDNEVELKAFVAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EHSIPTPPTSAAPSESTPSELPISPTTAPRTVKELTVSAGDNLIITLPDNEVELKAFVAP
300 310 320 330 340 350
370 380 390 400 410 420
pF1KSD APPVETTYNYEWNLISHPTDYQGEIKQGHKQTLNLSQLSVGLYVFKVTVSSENAFGEGFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APPVETTYNYEWNLISHPTDYQGEIKQGHKQTLNLSQLSVGLYVFKVTVSSENAFGEGFV
360 370 380 390 400 410
430 440 450 460 470 480
pF1KSD NVTVKPARRVNLPPVAVVSPQLQELTLPLTSALIDGSQSTDDTEIVSYHWEEINGPFIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NVTVKPARRVNLPPVAVVSPQLQELTLPLTSALIDGSQSTDDTEIVSYHWEEINGPFIEE
420 430 440 450 460 470
490 500 510 520 530 540
pF1KSD KTSVDSPVLRLSNLDPGNYSFRLTVTDSDGATNSTTAALIVNNAVDYPPVANAGPNHTIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KTSVDSPVLRLSNLDPGNYSFRLTVTDSDGATNSTTAALIVNNAVDYPPVANAGPNHTIT
480 490 500 510 520 530
550 560 570 580 590 600
pF1KSD LPQNSITLNGNQSSDDHQIVLYEWSLGPGSEGKHVVMQGVQTPYLHLSAMQEGDYTFQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPQNSITLNGNQSSDDHQIVLYEWSLGPGSEGKHVVMQGVQTPYLHLSAMQEGDYTFQLK
540 550 560 570 580 590
610 620 630 640 650 660
pF1KSD VTDSSRQQSTAVVTVIVQPENNRPPVAVAGPDKELIFPVESATLDGSSSSDDHGIVFYHW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTDSSRQQSTAVVTVIVQPENNRPPVAVAGPDKELIFPVESATLDGSSSSDDHGIVFYHW
600 610 620 630 640 650
670 680 690 700 710 720
pF1KSD EHVRGPSAVEMENIDKAIATVTGLQVGTYHFRLTVKDQQGLSSTSTLTVAVKKENNSPPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EHVRGPSAVEMENIDKAIATVTGLQVGTYHFRLTVKDQQGLSSTSTLTVAVKKENNSPPR
660 670 680 690 700 710
730 740 750 760 770 780
pF1KSD ARAGGRHVLVLPNNSITLDGSRSTDDQRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARAGGRHVLVLPNNSITLDGSRSTDDQRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTN
720 730 740 750 760 770
790 800 810 820 830 840
pF1KSD LVEGVYTFHLRVTDSQGASDTDTATVEVQPDPRKSGLVELTLQVGVGQLTEQRKDTLVRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVEGVYTFHLRVTDSQGASDTDTATVEVQPDPRKSGLVELTLQVGVGQLTEQRKDTLVRQ
780 790 800 810 820 830
850 860 870 880 890 900
pF1KSD LAVLLNVLDSDIKVQKIRAHSDLSTVIVFYVQSRPPFKVLKAAEVARNLHMRLSKEKADF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAVLLNVLDSDIKVQKIRAHSDLSTVIVFYVQSRPPFKVLKAAEVARNLHMRLSKEKADF
840 850 860 870 880 890
910 920 930 940 950 960
pF1KSD LLFKVLRVDTAGCLLKCSGHGHCDPLTKRCICSHLWMENLIQRYIWDGESNCEWSIFYVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLFKVLRVDTAGCLLKCSGHGHCDPLTKRCICSHLWMENLIQRYIWDGESNCEWSIFYVT
900 910 920 930 940 950
970 980 990 1000 1010 1020
pF1KSD VLAFTLIVLTGGFTWLCICCCKRQKRTKIRKKTKYTILDNMDEQERMELRPKYGIKHRST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLAFTLIVLTGGFTWLCICCCKRQKRTKIRKKTKYTILDNMDEQERMELRPKYGIKHRST
960 970 980 990 1000 1010
1030 1040 1050 1060 1070
pF1KSD EHNSSLMVSESEFDSDQDTIFSREKMERGNPKVSMNGSIRNGASFSYCSKDR
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EHNSSLMVSESEFDSDQDTIFSREKMERGNPKVSMNGSIRNGASFSYCSKDR
1020 1030 1040 1050 1060
>>XP_016867034 (OMIM: 600202,609269) PREDICTED: dyslexia (1027 aa)
initn: 6821 init1: 6821 opt: 6821 Z-score: 4548.1 bits: 853.2 E(85289): 0
Smith-Waterman score: 6821; 99.8% identity (99.9% similar) in 1027 aa overlap (46-1072:1-1027)
20 30 40 50 60 70
pF1KSD TIAGCARKQCSEGRTYSNAVISPNLETTRIMRVSHTFPVVDCTAACCDLSSCDLAWWFEG
::::::::::::::::::::::::::::::
XP_016 MRVSHTFPVVDCTAACCDLSSCDLAWWFEG
10 20 30
80 90 100 110 120 130
pF1KSD RCYLVSCPHKENCEPKKMGPIRSYLTFVLRPVQRPAQLLDYGDMMLNRGSPSGIWGDSPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RCYLVSCPHKENCEPKKMGPIRSYLTFVLRPVQRPAQLLDYGDMMLNRGSPSGIWGDSPE
40 50 60 70 80 90
140 150 160 170 180 190
pF1KSD DIRKDLPFLGKDWGLEEMSEYADDYRELEKDLLQPSGKQEPRGSAEYTDWGLLPGSEGAF
:::::: ::::::::::::::.::::::::::::::::::::::::::::::::::::::
XP_016 DIRKDLTFLGKDWGLEEMSEYSDDYRELEKDLLQPSGKQEPRGSAEYTDWGLLPGSEGAF
100 110 120 130 140 150
200 210 220 230 240 250
pF1KSD NSSVGDSPAVPAETQQDPELHYLNESASTPAPKLPERSVLLPLPTTPSSGEVLEKEKASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NSSVGDSPAVPAETQQDPELHYLNESASTPAPKLPERSVLLPLPTTPSSGEVLEKEKASQ
160 170 180 190 200 210
260 270 280 290 300 310
pF1KSD LQEQSSNSSGKEVLMPSHSLPPASLELSSVTVEKSPVLTVTPGSTEHSIPTPPTSAAPSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQEQSSNSSGKEVLMPSHSLPPASLELSSVTVEKSPVLTVTPGSTEHSIPTPPTSAAPSE
220 230 240 250 260 270
320 330 340 350 360 370
pF1KSD STPSELPISPTTAPRTVKELTVSAGDNLIITLPDNEVELKAFVAPAPPVETTYNYEWNLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STPSELPISPTTAPRTVKELTVSAGDNLIITLPDNEVELKAFVAPAPPVETTYNYEWNLI
280 290 300 310 320 330
380 390 400 410 420 430
pF1KSD SHPTDYQGEIKQGHKQTLNLSQLSVGLYVFKVTVSSENAFGEGFVNVTVKPARRVNLPPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SHPTDYQGEIKQGHKQTLNLSQLSVGLYVFKVTVSSENAFGEGFVNVTVKPARRVNLPPV
340 350 360 370 380 390
440 450 460 470 480 490
pF1KSD AVVSPQLQELTLPLTSALIDGSQSTDDTEIVSYHWEEINGPFIEEKTSVDSPVLRLSNLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVVSPQLQELTLPLTSALIDGSQSTDDTEIVSYHWEEINGPFIEEKTSVDSPVLRLSNLD
400 410 420 430 440 450
500 510 520 530 540 550
pF1KSD PGNYSFRLTVTDSDGATNSTTAALIVNNAVDYPPVANAGPNHTITLPQNSITLNGNQSSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PGNYSFRLTVTDSDGATNSTTAALIVNNAVDYPPVANAGPNHTITLPQNSITLNGNQSSD
460 470 480 490 500 510
560 570 580 590 600 610
pF1KSD DHQIVLYEWSLGPGSEGKHVVMQGVQTPYLHLSAMQEGDYTFQLKVTDSSRQQSTAVVTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DHQIVLYEWSLGPGSEGKHVVMQGVQTPYLHLSAMQEGDYTFQLKVTDSSRQQSTAVVTV
520 530 540 550 560 570
620 630 640 650 660 670
pF1KSD IVQPENNRPPVAVAGPDKELIFPVESATLDGSSSSDDHGIVFYHWEHVRGPSAVEMENID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IVQPENNRPPVAVAGPDKELIFPVESATLDGSSSSDDHGIVFYHWEHVRGPSAVEMENID
580 590 600 610 620 630
680 690 700 710 720 730
pF1KSD KAIATVTGLQVGTYHFRLTVKDQQGLSSTSTLTVAVKKENNSPPRARAGGRHVLVLPNNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KAIATVTGLQVGTYHFRLTVKDQQGLSSTSTLTVAVKKENNSPPRARAGGRHVLVLPNNS
640 650 660 670 680 690
740 750 760 770 780 790
pF1KSD ITLDGSRSTDDQRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTNLVEGVYTFHLRVTDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ITLDGSRSTDDQRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTNLVEGVYTFHLRVTDS
700 710 720 730 740 750
800 810 820 830 840 850
pF1KSD QGASDTDTATVEVQPDPRKSGLVELTLQVGVGQLTEQRKDTLVRQLAVLLNVLDSDIKVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGASDTDTATVEVQPDPRKSGLVELTLQVGVGQLTEQRKDTLVRQLAVLLNVLDSDIKVQ
760 770 780 790 800 810
860 870 880 890 900 910
pF1KSD KIRAHSDLSTVIVFYVQSRPPFKVLKAAEVARNLHMRLSKEKADFLLFKVLRVDTAGCLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KIRAHSDLSTVIVFYVQSRPPFKVLKAAEVARNLHMRLSKEKADFLLFKVLRVDTAGCLL
820 830 840 850 860 870
920 930 940 950 960 970
pF1KSD KCSGHGHCDPLTKRCICSHLWMENLIQRYIWDGESNCEWSIFYVTVLAFTLIVLTGGFTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KCSGHGHCDPLTKRCICSHLWMENLIQRYIWDGESNCEWSIFYVTVLAFTLIVLTGGFTW
880 890 900 910 920 930
980 990 1000 1010 1020 1030
pF1KSD LCICCCKRQKRTKIRKKTKYTILDNMDEQERMELRPKYGIKHRSTEHNSSLMVSESEFDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCICCCKRQKRTKIRKKTKYTILDNMDEQERMELRPKYGIKHRSTEHNSSLMVSESEFDS
940 950 960 970 980 990
1040 1050 1060 1070
pF1KSD DQDTIFSREKMERGNPKVSMNGSIRNGASFSYCSKDR
:::::::::::::::::::::::::::::::::::::
XP_016 DQDTIFSREKMERGNPKVSMNGSIRNGASFSYCSKDR
1000 1010 1020
>>XP_011513328 (OMIM: 600202,609269) PREDICTED: dyslexia (1027 aa)
initn: 6821 init1: 6821 opt: 6821 Z-score: 4548.1 bits: 853.2 E(85289): 0
Smith-Waterman score: 6821; 99.8% identity (99.9% similar) in 1027 aa overlap (46-1072:1-1027)
20 30 40 50 60 70
pF1KSD TIAGCARKQCSEGRTYSNAVISPNLETTRIMRVSHTFPVVDCTAACCDLSSCDLAWWFEG
::::::::::::::::::::::::::::::
XP_011 MRVSHTFPVVDCTAACCDLSSCDLAWWFEG
10 20 30
80 90 100 110 120 130
pF1KSD RCYLVSCPHKENCEPKKMGPIRSYLTFVLRPVQRPAQLLDYGDMMLNRGSPSGIWGDSPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RCYLVSCPHKENCEPKKMGPIRSYLTFVLRPVQRPAQLLDYGDMMLNRGSPSGIWGDSPE
40 50 60 70 80 90
140 150 160 170 180 190
pF1KSD DIRKDLPFLGKDWGLEEMSEYADDYRELEKDLLQPSGKQEPRGSAEYTDWGLLPGSEGAF
:::::: ::::::::::::::.::::::::::::::::::::::::::::::::::::::
XP_011 DIRKDLTFLGKDWGLEEMSEYSDDYRELEKDLLQPSGKQEPRGSAEYTDWGLLPGSEGAF
100 110 120 130 140 150
200 210 220 230 240 250
pF1KSD NSSVGDSPAVPAETQQDPELHYLNESASTPAPKLPERSVLLPLPTTPSSGEVLEKEKASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NSSVGDSPAVPAETQQDPELHYLNESASTPAPKLPERSVLLPLPTTPSSGEVLEKEKASQ
160 170 180 190 200 210
260 270 280 290 300 310
pF1KSD LQEQSSNSSGKEVLMPSHSLPPASLELSSVTVEKSPVLTVTPGSTEHSIPTPPTSAAPSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQEQSSNSSGKEVLMPSHSLPPASLELSSVTVEKSPVLTVTPGSTEHSIPTPPTSAAPSE
220 230 240 250 260 270
320 330 340 350 360 370
pF1KSD STPSELPISPTTAPRTVKELTVSAGDNLIITLPDNEVELKAFVAPAPPVETTYNYEWNLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 STPSELPISPTTAPRTVKELTVSAGDNLIITLPDNEVELKAFVAPAPPVETTYNYEWNLI
280 290 300 310 320 330
380 390 400 410 420 430
pF1KSD SHPTDYQGEIKQGHKQTLNLSQLSVGLYVFKVTVSSENAFGEGFVNVTVKPARRVNLPPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SHPTDYQGEIKQGHKQTLNLSQLSVGLYVFKVTVSSENAFGEGFVNVTVKPARRVNLPPV
340 350 360 370 380 390
440 450 460 470 480 490
pF1KSD AVVSPQLQELTLPLTSALIDGSQSTDDTEIVSYHWEEINGPFIEEKTSVDSPVLRLSNLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVVSPQLQELTLPLTSALIDGSQSTDDTEIVSYHWEEINGPFIEEKTSVDSPVLRLSNLD
400 410 420 430 440 450
500 510 520 530 540 550
pF1KSD PGNYSFRLTVTDSDGATNSTTAALIVNNAVDYPPVANAGPNHTITLPQNSITLNGNQSSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PGNYSFRLTVTDSDGATNSTTAALIVNNAVDYPPVANAGPNHTITLPQNSITLNGNQSSD
460 470 480 490 500 510
560 570 580 590 600 610
pF1KSD DHQIVLYEWSLGPGSEGKHVVMQGVQTPYLHLSAMQEGDYTFQLKVTDSSRQQSTAVVTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DHQIVLYEWSLGPGSEGKHVVMQGVQTPYLHLSAMQEGDYTFQLKVTDSSRQQSTAVVTV
520 530 540 550 560 570
620 630 640 650 660 670
pF1KSD IVQPENNRPPVAVAGPDKELIFPVESATLDGSSSSDDHGIVFYHWEHVRGPSAVEMENID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IVQPENNRPPVAVAGPDKELIFPVESATLDGSSSSDDHGIVFYHWEHVRGPSAVEMENID
580 590 600 610 620 630
680 690 700 710 720 730
pF1KSD KAIATVTGLQVGTYHFRLTVKDQQGLSSTSTLTVAVKKENNSPPRARAGGRHVLVLPNNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KAIATVTGLQVGTYHFRLTVKDQQGLSSTSTLTVAVKKENNSPPRARAGGRHVLVLPNNS
640 650 660 670 680 690
740 750 760 770 780 790
pF1KSD ITLDGSRSTDDQRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTNLVEGVYTFHLRVTDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ITLDGSRSTDDQRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTNLVEGVYTFHLRVTDS
700 710 720 730 740 750
800 810 820 830 840 850
pF1KSD QGASDTDTATVEVQPDPRKSGLVELTLQVGVGQLTEQRKDTLVRQLAVLLNVLDSDIKVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGASDTDTATVEVQPDPRKSGLVELTLQVGVGQLTEQRKDTLVRQLAVLLNVLDSDIKVQ
760 770 780 790 800 810
860 870 880 890 900 910
pF1KSD KIRAHSDLSTVIVFYVQSRPPFKVLKAAEVARNLHMRLSKEKADFLLFKVLRVDTAGCLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KIRAHSDLSTVIVFYVQSRPPFKVLKAAEVARNLHMRLSKEKADFLLFKVLRVDTAGCLL
820 830 840 850 860 870
920 930 940 950 960 970
pF1KSD KCSGHGHCDPLTKRCICSHLWMENLIQRYIWDGESNCEWSIFYVTVLAFTLIVLTGGFTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KCSGHGHCDPLTKRCICSHLWMENLIQRYIWDGESNCEWSIFYVTVLAFTLIVLTGGFTW
880 890 900 910 920 930
980 990 1000 1010 1020 1030
pF1KSD LCICCCKRQKRTKIRKKTKYTILDNMDEQERMELRPKYGIKHRSTEHNSSLMVSESEFDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LCICCCKRQKRTKIRKKTKYTILDNMDEQERMELRPKYGIKHRSTEHNSSLMVSESEFDS
940 950 960 970 980 990
1040 1050 1060 1070
pF1KSD DQDTIFSREKMERGNPKVSMNGSIRNGASFSYCSKDR
:::::::::::::::::::::::::::::::::::::
XP_011 DQDTIFSREKMERGNPKVSMNGSIRNGASFSYCSKDR
1000 1010 1020
>>NP_001161848 (OMIM: 600202,609269) dyslexia-associated (1027 aa)
initn: 6821 init1: 6821 opt: 6821 Z-score: 4548.1 bits: 853.2 E(85289): 0
Smith-Waterman score: 6821; 99.8% identity (99.9% similar) in 1027 aa overlap (46-1072:1-1027)
20 30 40 50 60 70
pF1KSD TIAGCARKQCSEGRTYSNAVISPNLETTRIMRVSHTFPVVDCTAACCDLSSCDLAWWFEG
::::::::::::::::::::::::::::::
NP_001 MRVSHTFPVVDCTAACCDLSSCDLAWWFEG
10 20 30
80 90 100 110 120 130
pF1KSD RCYLVSCPHKENCEPKKMGPIRSYLTFVLRPVQRPAQLLDYGDMMLNRGSPSGIWGDSPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RCYLVSCPHKENCEPKKMGPIRSYLTFVLRPVQRPAQLLDYGDMMLNRGSPSGIWGDSPE
40 50 60 70 80 90
140 150 160 170 180 190
pF1KSD DIRKDLPFLGKDWGLEEMSEYADDYRELEKDLLQPSGKQEPRGSAEYTDWGLLPGSEGAF
:::::: ::::::::::::::.::::::::::::::::::::::::::::::::::::::
NP_001 DIRKDLTFLGKDWGLEEMSEYSDDYRELEKDLLQPSGKQEPRGSAEYTDWGLLPGSEGAF
100 110 120 130 140 150
200 210 220 230 240 250
pF1KSD NSSVGDSPAVPAETQQDPELHYLNESASTPAPKLPERSVLLPLPTTPSSGEVLEKEKASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NSSVGDSPAVPAETQQDPELHYLNESASTPAPKLPERSVLLPLPTTPSSGEVLEKEKASQ
160 170 180 190 200 210
260 270 280 290 300 310
pF1KSD LQEQSSNSSGKEVLMPSHSLPPASLELSSVTVEKSPVLTVTPGSTEHSIPTPPTSAAPSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQEQSSNSSGKEVLMPSHSLPPASLELSSVTVEKSPVLTVTPGSTEHSIPTPPTSAAPSE
220 230 240 250 260 270
320 330 340 350 360 370
pF1KSD STPSELPISPTTAPRTVKELTVSAGDNLIITLPDNEVELKAFVAPAPPVETTYNYEWNLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STPSELPISPTTAPRTVKELTVSAGDNLIITLPDNEVELKAFVAPAPPVETTYNYEWNLI
280 290 300 310 320 330
380 390 400 410 420 430
pF1KSD SHPTDYQGEIKQGHKQTLNLSQLSVGLYVFKVTVSSENAFGEGFVNVTVKPARRVNLPPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SHPTDYQGEIKQGHKQTLNLSQLSVGLYVFKVTVSSENAFGEGFVNVTVKPARRVNLPPV
340 350 360 370 380 390
440 450 460 470 480 490
pF1KSD AVVSPQLQELTLPLTSALIDGSQSTDDTEIVSYHWEEINGPFIEEKTSVDSPVLRLSNLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVVSPQLQELTLPLTSALIDGSQSTDDTEIVSYHWEEINGPFIEEKTSVDSPVLRLSNLD
400 410 420 430 440 450
500 510 520 530 540 550
pF1KSD PGNYSFRLTVTDSDGATNSTTAALIVNNAVDYPPVANAGPNHTITLPQNSITLNGNQSSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGNYSFRLTVTDSDGATNSTTAALIVNNAVDYPPVANAGPNHTITLPQNSITLNGNQSSD
460 470 480 490 500 510
560 570 580 590 600 610
pF1KSD DHQIVLYEWSLGPGSEGKHVVMQGVQTPYLHLSAMQEGDYTFQLKVTDSSRQQSTAVVTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DHQIVLYEWSLGPGSEGKHVVMQGVQTPYLHLSAMQEGDYTFQLKVTDSSRQQSTAVVTV
520 530 540 550 560 570
620 630 640 650 660 670
pF1KSD IVQPENNRPPVAVAGPDKELIFPVESATLDGSSSSDDHGIVFYHWEHVRGPSAVEMENID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IVQPENNRPPVAVAGPDKELIFPVESATLDGSSSSDDHGIVFYHWEHVRGPSAVEMENID
580 590 600 610 620 630
680 690 700 710 720 730
pF1KSD KAIATVTGLQVGTYHFRLTVKDQQGLSSTSTLTVAVKKENNSPPRARAGGRHVLVLPNNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KAIATVTGLQVGTYHFRLTVKDQQGLSSTSTLTVAVKKENNSPPRARAGGRHVLVLPNNS
640 650 660 670 680 690
740 750 760 770 780 790
pF1KSD ITLDGSRSTDDQRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTNLVEGVYTFHLRVTDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ITLDGSRSTDDQRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTNLVEGVYTFHLRVTDS
700 710 720 730 740 750
800 810 820 830 840 850
pF1KSD QGASDTDTATVEVQPDPRKSGLVELTLQVGVGQLTEQRKDTLVRQLAVLLNVLDSDIKVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QGASDTDTATVEVQPDPRKSGLVELTLQVGVGQLTEQRKDTLVRQLAVLLNVLDSDIKVQ
760 770 780 790 800 810
860 870 880 890 900 910
pF1KSD KIRAHSDLSTVIVFYVQSRPPFKVLKAAEVARNLHMRLSKEKADFLLFKVLRVDTAGCLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KIRAHSDLSTVIVFYVQSRPPFKVLKAAEVARNLHMRLSKEKADFLLFKVLRVDTAGCLL
820 830 840 850 860 870
920 930 940 950 960 970
pF1KSD KCSGHGHCDPLTKRCICSHLWMENLIQRYIWDGESNCEWSIFYVTVLAFTLIVLTGGFTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KCSGHGHCDPLTKRCICSHLWMENLIQRYIWDGESNCEWSIFYVTVLAFTLIVLTGGFTW
880 890 900 910 920 930
980 990 1000 1010 1020 1030
pF1KSD LCICCCKRQKRTKIRKKTKYTILDNMDEQERMELRPKYGIKHRSTEHNSSLMVSESEFDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCICCCKRQKRTKIRKKTKYTILDNMDEQERMELRPKYGIKHRSTEHNSSLMVSESEFDS
940 950 960 970 980 990
1040 1050 1060 1070
pF1KSD DQDTIFSREKMERGNPKVSMNGSIRNGASFSYCSKDR
:::::::::::::::::::::::::::::::::::::
NP_001 DQDTIFSREKMERGNPKVSMNGSIRNGASFSYCSKDR
1000 1010 1020
>>XP_016867031 (OMIM: 600202,609269) PREDICTED: dyslexia (1047 aa)
initn: 6717 init1: 6717 opt: 6720 Z-score: 4480.8 bits: 840.8 E(85289): 0
Smith-Waterman score: 6720; 98.9% identity (99.5% similar) in 1024 aa overlap (1-1024:1-1024)
10 20 30 40 50 60
pF1KSD MAPPTGVLSSLLLLVTIAGCARKQCSEGRTYSNAVISPNLETTRIMRVSHTFPVVDCTAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAPPTGVLSSLLLLVTIAGCARKQCSEGRTYSNAVISPNLETTRIMRVSHTFPVVDCTAA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD CCDLSSCDLAWWFEGRCYLVSCPHKENCEPKKMGPIRSYLTFVLRPVQRPAQLLDYGDMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CCDLSSCDLAWWFEGRCYLVSCPHKENCEPKKMGPIRSYLTFVLRPVQRPAQLLDYGDMM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD LNRGSPSGIWGDSPEDIRKDLPFLGKDWGLEEMSEYADDYRELEKDLLQPSGKQEPRGSA
::::::::::::::::::::: ::::::::::::::.:::::::::::::::::::::::
XP_016 LNRGSPSGIWGDSPEDIRKDLTFLGKDWGLEEMSEYSDDYRELEKDLLQPSGKQEPRGSA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD EYTDWGLLPGSEGAFNSSVGDSPAVPAETQQDPELHYLNESASTPAPKLPERSVLLPLPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EYTDWGLLPGSEGAFNSSVGDSPAVPAETQQDPELHYLNESASTPAPKLPERSVLLPLPT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD TPSSGEVLEKEKASQLQEQSSNSSGKEVLMPSHSLPPASLELSSVTVEKSPVLTVTPGST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPSSGEVLEKEKASQLQEQSSNSSGKEVLMPSHSLPPASLELSSVTVEKSPVLTVTPGST
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD EHSIPTPPTSAAPSESTPSELPISPTTAPRTVKELTVSAGDNLIITLPDNEVELKAFVAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EHSIPTPPTSAAPSESTPSELPISPTTAPRTVKELTVSAGDNLIITLPDNEVELKAFVAP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD APPVETTYNYEWNLISHPTDYQGEIKQGHKQTLNLSQLSVGLYVFKVTVSSENAFGEGFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APPVETTYNYEWNLISHPTDYQGEIKQGHKQTLNLSQLSVGLYVFKVTVSSENAFGEGFV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD NVTVKPARRVNLPPVAVVSPQLQELTLPLTSALIDGSQSTDDTEIVSYHWEEINGPFIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NVTVKPARRVNLPPVAVVSPQLQELTLPLTSALIDGSQSTDDTEIVSYHWEEINGPFIEE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD KTSVDSPVLRLSNLDPGNYSFRLTVTDSDGATNSTTAALIVNNAVDYPPVANAGPNHTIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KTSVDSPVLRLSNLDPGNYSFRLTVTDSDGATNSTTAALIVNNAVDYPPVANAGPNHTIT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD LPQNSITLNGNQSSDDHQIVLYEWSLGPGSEGKHVVMQGVQTPYLHLSAMQEGDYTFQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPQNSITLNGNQSSDDHQIVLYEWSLGPGSEGKHVVMQGVQTPYLHLSAMQEGDYTFQLK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD VTDSSRQQSTAVVTVIVQPENNRPPVAVAGPDKELIFPVESATLDGSSSSDDHGIVFYHW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTDSSRQQSTAVVTVIVQPENNRPPVAVAGPDKELIFPVESATLDGSSSSDDHGIVFYHW
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD EHVRGPSAVEMENIDKAIATVTGLQVGTYHFRLTVKDQQGLSSTSTLTVAVKKENNSPPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EHVRGPSAVEMENIDKAIATVTGLQVGTYHFRLTVKDQQGLSSTSTLTVAVKKENNSPPR
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD ARAGGRHVLVLPNNSITLDGSRSTDDQRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARAGGRHVLVLPNNSITLDGSRSTDDQRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD LVEGVYTFHLRVTDSQGASDTDTATVEVQPDPRKSGLVELTLQVGVGQLTEQRKDTLVRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVEGVYTFHLRVTDSQGASDTDTATVEVQPDPRKSGLVELTLQVGVGQLTEQRKDTLVRQ
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD LAVLLNVLDSDIKVQKIRAHSDLSTVIVFYVQSRPPFKVLKAAEVARNLHMRLSKEKADF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAVLLNVLDSDIKVQKIRAHSDLSTVIVFYVQSRPPFKVLKAAEVARNLHMRLSKEKADF
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD LLFKVLRVDTAGCLLKCSGHGHCDPLTKRCICSHLWMENLIQRYIWDGESNCEWSIFYVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLFKVLRVDTAGCLLKCSGHGHCDPLTKRCICSHLWMENLIQRYIWDGESNCEWSIFYVT
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD VLAFTLIVLTGGFTWLCICCCKRQKRTKIRKKTKYTILDNMDEQERMELRPKYGIKHRST
::::::::::::::::::::::::::::::::::::::::::::::::::::: . :.
XP_016 VLAFTLIVLTGGFTWLCICCCKRQKRTKIRKKTKYTILDNMDEQERMELRPKYEEEIRTC
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070
pF1KSD EHNSSLMVSESEFDSDQDTIFSREKMERGNPKVSMNGSIRNGASFSYCSKDR
...:
XP_016 RETSGARRHRGKIMGGHGKKAAIYKPR
1030 1040
>>XP_016867035 (OMIM: 600202,609269) PREDICTED: dyslexia (986 aa)
initn: 6738 init1: 6301 opt: 6301 Z-score: 4202.7 bits: 789.2 E(85289): 0
Smith-Waterman score: 6301; 99.6% identity (99.7% similar) in 956 aa overlap (1-956:1-956)
10 20 30 40 50 60
pF1KSD MAPPTGVLSSLLLLVTIAGCARKQCSEGRTYSNAVISPNLETTRIMRVSHTFPVVDCTAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAPPTGVLSSLLLLVTIAGCARKQCSEGRTYSNAVISPNLETTRIMRVSHTFPVVDCTAA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD CCDLSSCDLAWWFEGRCYLVSCPHKENCEPKKMGPIRSYLTFVLRPVQRPAQLLDYGDMM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CCDLSSCDLAWWFEGRCYLVSCPHKENCEPKKMGPIRSYLTFVLRPVQRPAQLLDYGDMM
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD LNRGSPSGIWGDSPEDIRKDLPFLGKDWGLEEMSEYADDYRELEKDLLQPSGKQEPRGSA
::::::::::::::::::::: ::::::::::::::.:::::::::::::::::::::::
XP_016 LNRGSPSGIWGDSPEDIRKDLTFLGKDWGLEEMSEYSDDYRELEKDLLQPSGKQEPRGSA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD EYTDWGLLPGSEGAFNSSVGDSPAVPAETQQDPELHYLNESASTPAPKLPERSVLLPLPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EYTDWGLLPGSEGAFNSSVGDSPAVPAETQQDPELHYLNESASTPAPKLPERSVLLPLPT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD TPSSGEVLEKEKASQLQEQSSNSSGKEVLMPSHSLPPASLELSSVTVEKSPVLTVTPGST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPSSGEVLEKEKASQLQEQSSNSSGKEVLMPSHSLPPASLELSSVTVEKSPVLTVTPGST
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD EHSIPTPPTSAAPSESTPSELPISPTTAPRTVKELTVSAGDNLIITLPDNEVELKAFVAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EHSIPTPPTSAAPSESTPSELPISPTTAPRTVKELTVSAGDNLIITLPDNEVELKAFVAP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD APPVETTYNYEWNLISHPTDYQGEIKQGHKQTLNLSQLSVGLYVFKVTVSSENAFGEGFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 APPVETTYNYEWNLISHPTDYQGEIKQGHKQTLNLSQLSVGLYVFKVTVSSENAFGEGFV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD NVTVKPARRVNLPPVAVVSPQLQELTLPLTSALIDGSQSTDDTEIVSYHWEEINGPFIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NVTVKPARRVNLPPVAVVSPQLQELTLPLTSALIDGSQSTDDTEIVSYHWEEINGPFIEE
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD KTSVDSPVLRLSNLDPGNYSFRLTVTDSDGATNSTTAALIVNNAVDYPPVANAGPNHTIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KTSVDSPVLRLSNLDPGNYSFRLTVTDSDGATNSTTAALIVNNAVDYPPVANAGPNHTIT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD LPQNSITLNGNQSSDDHQIVLYEWSLGPGSEGKHVVMQGVQTPYLHLSAMQEGDYTFQLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPQNSITLNGNQSSDDHQIVLYEWSLGPGSEGKHVVMQGVQTPYLHLSAMQEGDYTFQLK
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD VTDSSRQQSTAVVTVIVQPENNRPPVAVAGPDKELIFPVESATLDGSSSSDDHGIVFYHW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTDSSRQQSTAVVTVIVQPENNRPPVAVAGPDKELIFPVESATLDGSSSSDDHGIVFYHW
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD EHVRGPSAVEMENIDKAIATVTGLQVGTYHFRLTVKDQQGLSSTSTLTVAVKKENNSPPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EHVRGPSAVEMENIDKAIATVTGLQVGTYHFRLTVKDQQGLSSTSTLTVAVKKENNSPPR
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD ARAGGRHVLVLPNNSITLDGSRSTDDQRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ARAGGRHVLVLPNNSITLDGSRSTDDQRIVSYLWIRDGQSPAAGDVIDGSDHSVALQLTN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KSD LVEGVYTFHLRVTDSQGASDTDTATVEVQPDPRKSGLVELTLQVGVGQLTEQRKDTLVRQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVEGVYTFHLRVTDSQGASDTDTATVEVQPDPRKSGLVELTLQVGVGQLTEQRKDTLVRQ
790 800 810 820 830 840
850 860 870 880 890 900
pF1KSD LAVLLNVLDSDIKVQKIRAHSDLSTVIVFYVQSRPPFKVLKAAEVARNLHMRLSKEKADF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAVLLNVLDSDIKVQKIRAHSDLSTVIVFYVQSRPPFKVLKAAEVARNLHMRLSKEKADF
850 860 870 880 890 900
910 920 930 940 950 960
pF1KSD LLFKVLRVDTAGCLLKCSGHGHCDPLTKRCICSHLWMENLIQRYIWDGESNCEWSIFYVT
::::::::::::::::::::::::::::::::::::::::::::::::::::: :
XP_016 LLFKVLRVDTAGCLLKCSGHGHCDPLTKRCICSHLWMENLIQRYIWDGESNCEEEIRTCR
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KSD VLAFTLIVLTGGFTWLCICCCKRQKRTKIRKKTKYTILDNMDEQERMELRPKYGIKHRST
XP_016 ETSGARRHRGKIMGGHGKKAAIYKPR
970 980
1072 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 01:15:55 2016 done: Thu Nov 3 01:15:57 2016
Total Scan time: 13.490 Total Display time: 0.360
Function used was FASTA [36.3.4 Apr, 2011]