Result of FASTA (omim) for
pFN21ASDA0210
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KSDA0210, 795 aa
1>>>pF1KSDA0210 795 - 795 aa - 795 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.8423+/-0.000372; mu= 9.4726+/- 0.023
mean_var=153.3255+/-31.707, 0's: 0 Z-trim(118.0): 59 B-trim: 761 in 1/54
Lambda= 0.103578
statistics sampled from 30427 (30490) to 30427 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.699), E-opt: 0.2 (0.357), width: 16
Scan time: 10.280
The best scores are: opt bits E(85289)
XP_005265671 (OMIM: 615740) PREDICTED: TBC1 domain ( 795) 5283 801.8 0
XP_016863048 (OMIM: 615740) PREDICTED: TBC1 domain ( 795) 5283 801.8 0
XP_016863049 (OMIM: 615740) PREDICTED: TBC1 domain ( 795) 5283 801.8 0
XP_016863050 (OMIM: 615740) PREDICTED: TBC1 domain ( 795) 5283 801.8 0
NP_055559 (OMIM: 615740) TBC1 domain family member ( 795) 5283 801.8 0
XP_016863046 (OMIM: 615740) PREDICTED: TBC1 domain ( 795) 5283 801.8 0
XP_016863047 (OMIM: 615740) PREDICTED: TBC1 domain ( 795) 5283 801.8 0
XP_016863053 (OMIM: 615740) PREDICTED: TBC1 domain ( 659) 4362 664.1 5.4e-190
XP_016863054 (OMIM: 615740) PREDICTED: TBC1 domain ( 659) 4362 664.1 5.4e-190
XP_016863052 (OMIM: 615740) PREDICTED: TBC1 domain ( 659) 4362 664.1 5.4e-190
XP_016863056 (OMIM: 615740) PREDICTED: TBC1 domain ( 659) 4362 664.1 5.4e-190
XP_016863055 (OMIM: 615740) PREDICTED: TBC1 domain ( 659) 4362 664.1 5.4e-190
XP_016863042 (OMIM: 615740) PREDICTED: TBC1 domain ( 817) 3576 546.7 1.5e-154
XP_016863041 (OMIM: 615740) PREDICTED: TBC1 domain ( 817) 3576 546.7 1.5e-154
XP_011532586 (OMIM: 615740) PREDICTED: TBC1 domain ( 817) 3576 546.7 1.5e-154
XP_016863045 (OMIM: 615740) PREDICTED: TBC1 domain ( 817) 3576 546.7 1.5e-154
XP_011532583 (OMIM: 615740) PREDICTED: TBC1 domain ( 817) 3576 546.7 1.5e-154
XP_005265668 (OMIM: 615740) PREDICTED: TBC1 domain ( 817) 3576 546.7 1.5e-154
XP_006713493 (OMIM: 615740) PREDICTED: TBC1 domain ( 817) 3576 546.7 1.5e-154
XP_016863043 (OMIM: 615740) PREDICTED: TBC1 domain ( 817) 3576 546.7 1.5e-154
XP_016863044 (OMIM: 615740) PREDICTED: TBC1 domain ( 817) 3576 546.7 1.5e-154
NP_001127853 (OMIM: 615740) TBC1 domain family mem ( 817) 3576 546.7 1.5e-154
XP_005265669 (OMIM: 615740) PREDICTED: TBC1 domain ( 817) 3576 546.7 1.5e-154
XP_011532585 (OMIM: 615740) PREDICTED: TBC1 domain ( 817) 3576 546.7 1.5e-154
XP_011532588 (OMIM: 615740) PREDICTED: TBC1 domain ( 817) 3576 546.7 1.5e-154
XP_016863057 (OMIM: 615740) PREDICTED: TBC1 domain ( 444) 3008 461.7 3.2e-129
XP_011532589 (OMIM: 615740) PREDICTED: TBC1 domain ( 681) 2655 409.0 3.4e-113
XP_016863051 (OMIM: 615740) PREDICTED: TBC1 domain ( 681) 2655 409.0 3.4e-113
XP_005265673 (OMIM: 615740) PREDICTED: TBC1 domain ( 681) 2655 409.0 3.4e-113
XP_005265672 (OMIM: 615740) PREDICTED: TBC1 domain ( 681) 2655 409.0 3.4e-113
XP_005252117 (OMIM: 616218) PREDICTED: TBC1 domain ( 324) 272 52.7 2.9e-06
NP_060671 (OMIM: 616218) TBC1 domain family member ( 400) 272 52.8 3.4e-06
NP_001273701 (OMIM: 616218) TBC1 domain family mem ( 275) 223 45.4 0.00041
XP_016884231 (OMIM: 616879) PREDICTED: TBC1 domain ( 549) 225 45.9 0.00058
>>XP_005265671 (OMIM: 615740) PREDICTED: TBC1 domain fam (795 aa)
initn: 5283 init1: 5283 opt: 5283 Z-score: 4274.6 bits: 801.8 E(85289): 0
Smith-Waterman score: 5283; 100.0% identity (100.0% similar) in 795 aa overlap (1-795:1-795)
10 20 30 40 50 60
pF1KSD MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGLSSKNISSSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGLSSKNISSSP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD SVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEEELEAQISFLQGQLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEEELEAQISFLQGQLN
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD DLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD EAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGCTDRGNSDDFILISK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGCTDRGNSDDFILISK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD DDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPASASSSNPSSSPDDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPASASSSNPSSSPDDD
730 740 750 760 770 780
790
pF1KSD SSKDSGFTIVSPLDI
:::::::::::::::
XP_005 SSKDSGFTIVSPLDI
790
>>XP_016863048 (OMIM: 615740) PREDICTED: TBC1 domain fam (795 aa)
initn: 5283 init1: 5283 opt: 5283 Z-score: 4274.6 bits: 801.8 E(85289): 0
Smith-Waterman score: 5283; 100.0% identity (100.0% similar) in 795 aa overlap (1-795:1-795)
10 20 30 40 50 60
pF1KSD MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGLSSKNISSSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGLSSKNISSSP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD SVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEEELEAQISFLQGQLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEEELEAQISFLQGQLN
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD DLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD EAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGCTDRGNSDDFILISK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGCTDRGNSDDFILISK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD DDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPASASSSNPSSSPDDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPASASSSNPSSSPDDD
730 740 750 760 770 780
790
pF1KSD SSKDSGFTIVSPLDI
:::::::::::::::
XP_016 SSKDSGFTIVSPLDI
790
>>XP_016863049 (OMIM: 615740) PREDICTED: TBC1 domain fam (795 aa)
initn: 5283 init1: 5283 opt: 5283 Z-score: 4274.6 bits: 801.8 E(85289): 0
Smith-Waterman score: 5283; 100.0% identity (100.0% similar) in 795 aa overlap (1-795:1-795)
10 20 30 40 50 60
pF1KSD MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGLSSKNISSSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGLSSKNISSSP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD SVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEEELEAQISFLQGQLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEEELEAQISFLQGQLN
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD DLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD EAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGCTDRGNSDDFILISK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGCTDRGNSDDFILISK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD DDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPASASSSNPSSSPDDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPASASSSNPSSSPDDD
730 740 750 760 770 780
790
pF1KSD SSKDSGFTIVSPLDI
:::::::::::::::
XP_016 SSKDSGFTIVSPLDI
790
>>XP_016863050 (OMIM: 615740) PREDICTED: TBC1 domain fam (795 aa)
initn: 5283 init1: 5283 opt: 5283 Z-score: 4274.6 bits: 801.8 E(85289): 0
Smith-Waterman score: 5283; 100.0% identity (100.0% similar) in 795 aa overlap (1-795:1-795)
10 20 30 40 50 60
pF1KSD MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGLSSKNISSSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGLSSKNISSSP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD SVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEEELEAQISFLQGQLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEEELEAQISFLQGQLN
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD DLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD EAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGCTDRGNSDDFILISK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGCTDRGNSDDFILISK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD DDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPASASSSNPSSSPDDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPASASSSNPSSSPDDD
730 740 750 760 770 780
790
pF1KSD SSKDSGFTIVSPLDI
:::::::::::::::
XP_016 SSKDSGFTIVSPLDI
790
>>NP_055559 (OMIM: 615740) TBC1 domain family member 5 i (795 aa)
initn: 5283 init1: 5283 opt: 5283 Z-score: 4274.6 bits: 801.8 E(85289): 0
Smith-Waterman score: 5283; 100.0% identity (100.0% similar) in 795 aa overlap (1-795:1-795)
10 20 30 40 50 60
pF1KSD MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGLSSKNISSSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGLSSKNISSSP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD SVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEEELEAQISFLQGQLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 SVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEEELEAQISFLQGQLN
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD DLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD EAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGCTDRGNSDDFILISK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 EAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGCTDRGNSDDFILISK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD DDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPASASSSNPSSSPDDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 DDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPASASSSNPSSSPDDD
730 740 750 760 770 780
790
pF1KSD SSKDSGFTIVSPLDI
:::::::::::::::
NP_055 SSKDSGFTIVSPLDI
790
>>XP_016863046 (OMIM: 615740) PREDICTED: TBC1 domain fam (795 aa)
initn: 5283 init1: 5283 opt: 5283 Z-score: 4274.6 bits: 801.8 E(85289): 0
Smith-Waterman score: 5283; 100.0% identity (100.0% similar) in 795 aa overlap (1-795:1-795)
10 20 30 40 50 60
pF1KSD MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGLSSKNISSSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGLSSKNISSSP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD SVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEEELEAQISFLQGQLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEEELEAQISFLQGQLN
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD DLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD EAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGCTDRGNSDDFILISK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGCTDRGNSDDFILISK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD DDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPASASSSNPSSSPDDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPASASSSNPSSSPDDD
730 740 750 760 770 780
790
pF1KSD SSKDSGFTIVSPLDI
:::::::::::::::
XP_016 SSKDSGFTIVSPLDI
790
>>XP_016863047 (OMIM: 615740) PREDICTED: TBC1 domain fam (795 aa)
initn: 5283 init1: 5283 opt: 5283 Z-score: 4274.6 bits: 801.8 E(85289): 0
Smith-Waterman score: 5283; 100.0% identity (100.0% similar) in 795 aa overlap (1-795:1-795)
10 20 30 40 50 60
pF1KSD MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MYHSLSETRHPLQPEEQEVGIDPLSSYSNKSGGDSNKNGRRTSSTLDSEGTFNSYRKEWE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KSD ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELFVNNNYLATIRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWISRIEELRAWYSNIK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KSD EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQDVKRTFPEMQFFQQE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KSD NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLHASESAQPSEEMKTV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KSD LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFARPQDLGPTIAIVTK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KSD VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQDLLVVWDALFADGL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KSD SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLILKALFLRDPKRNPRP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KSD VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGRKLISPAMAPGSAGG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KSD PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGLSSKNISSSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQLNKGLSSKNISSSP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KSD SVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEEELEAQISFLQGQLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEEELEAQISFLQGQLN
550 560 570 580 590 600
610 620 630 640 650 660
pF1KSD DLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIKDILKGSLRFNQSQL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KSD EAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGCTDRGNSDDFILISK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGCTDRGNSDDFILISK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KSD DDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPASASSSNPSSSPDDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPASASSSNPSSSPDDD
730 740 750 760 770 780
790
pF1KSD SSKDSGFTIVSPLDI
:::::::::::::::
XP_016 SSKDSGFTIVSPLDI
790
>>XP_016863053 (OMIM: 615740) PREDICTED: TBC1 domain fam (659 aa)
initn: 4362 init1: 4362 opt: 4362 Z-score: 3532.0 bits: 664.1 E(85289): 5.4e-190
Smith-Waterman score: 4362; 100.0% identity (100.0% similar) in 659 aa overlap (137-795:1-659)
110 120 130 140 150 160
pF1KSD SRIEELRAWYSNIKEIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQD
::::::::::::::::::::::::::::::
XP_016 MINNPLSQDEGSLWNKFFQDKELRSMIEQD
10 20 30
170 180 190 200 210 220
pF1KSD VKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLH
40 50 60 70 80 90
230 240 250 260 270 280
pF1KSD ASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFA
100 110 120 130 140 150
290 300 310 320 330 340
pF1KSD RPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQ
160 170 180 190 200 210
350 360 370 380 390 400
pF1KSD DLLVVWDALFADGLSLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLLVVWDALFADGLSLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLIL
220 230 240 250 260 270
410 420 430 440 450 460
pF1KSD KALFLRDPKRNPRPVTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KALFLRDPKRNPRPVTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGR
280 290 300 310 320 330
470 480 490 500 510 520
pF1KSD KLISPAMAPGSAGGPVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLISPAMAPGSAGGPVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQ
340 350 360 370 380 390
530 540 550 560 570 580
pF1KSD LNKGLSSKNISSSPSVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNKGLSSKNISSSPSVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEE
400 410 420 430 440 450
590 600 610 620 630 640
pF1KSD ELEAQISFLQGQLNDLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELEAQISFLQGQLNDLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIK
460 470 480 490 500 510
650 660 670 680 690 700
pF1KSD DILKGSLRFNQSQLEAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DILKGSLRFNQSQLEAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGC
520 530 540 550 560 570
710 720 730 740 750 760
pF1KSD TDRGNSDDFILISKDDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDRGNSDDFILISKDDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPA
580 590 600 610 620 630
770 780 790
pF1KSD SASSSNPSSSPDDDSSKDSGFTIVSPLDI
:::::::::::::::::::::::::::::
XP_016 SASSSNPSSSPDDDSSKDSGFTIVSPLDI
640 650
>>XP_016863054 (OMIM: 615740) PREDICTED: TBC1 domain fam (659 aa)
initn: 4362 init1: 4362 opt: 4362 Z-score: 3532.0 bits: 664.1 E(85289): 5.4e-190
Smith-Waterman score: 4362; 100.0% identity (100.0% similar) in 659 aa overlap (137-795:1-659)
110 120 130 140 150 160
pF1KSD SRIEELRAWYSNIKEIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQD
::::::::::::::::::::::::::::::
XP_016 MINNPLSQDEGSLWNKFFQDKELRSMIEQD
10 20 30
170 180 190 200 210 220
pF1KSD VKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLH
40 50 60 70 80 90
230 240 250 260 270 280
pF1KSD ASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFA
100 110 120 130 140 150
290 300 310 320 330 340
pF1KSD RPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQ
160 170 180 190 200 210
350 360 370 380 390 400
pF1KSD DLLVVWDALFADGLSLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLLVVWDALFADGLSLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLIL
220 230 240 250 260 270
410 420 430 440 450 460
pF1KSD KALFLRDPKRNPRPVTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KALFLRDPKRNPRPVTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGR
280 290 300 310 320 330
470 480 490 500 510 520
pF1KSD KLISPAMAPGSAGGPVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLISPAMAPGSAGGPVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQ
340 350 360 370 380 390
530 540 550 560 570 580
pF1KSD LNKGLSSKNISSSPSVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNKGLSSKNISSSPSVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEE
400 410 420 430 440 450
590 600 610 620 630 640
pF1KSD ELEAQISFLQGQLNDLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELEAQISFLQGQLNDLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIK
460 470 480 490 500 510
650 660 670 680 690 700
pF1KSD DILKGSLRFNQSQLEAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DILKGSLRFNQSQLEAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGC
520 530 540 550 560 570
710 720 730 740 750 760
pF1KSD TDRGNSDDFILISKDDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDRGNSDDFILISKDDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPA
580 590 600 610 620 630
770 780 790
pF1KSD SASSSNPSSSPDDDSSKDSGFTIVSPLDI
:::::::::::::::::::::::::::::
XP_016 SASSSNPSSSPDDDSSKDSGFTIVSPLDI
640 650
>>XP_016863052 (OMIM: 615740) PREDICTED: TBC1 domain fam (659 aa)
initn: 4362 init1: 4362 opt: 4362 Z-score: 3532.0 bits: 664.1 E(85289): 5.4e-190
Smith-Waterman score: 4362; 100.0% identity (100.0% similar) in 659 aa overlap (137-795:1-659)
110 120 130 140 150 160
pF1KSD SRIEELRAWYSNIKEIHITNPRKVVGQQDLMINNPLSQDEGSLWNKFFQDKELRSMIEQD
::::::::::::::::::::::::::::::
XP_016 MINNPLSQDEGSLWNKFFQDKELRSMIEQD
10 20 30
170 180 190 200 210 220
pF1KSD VKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKRTFPEMQFFQQENVRKILTDVLFCYARENEQLLYKQGMHELLAPIVFVLHCDHQAFLH
40 50 60 70 80 90
230 240 250 260 270 280
pF1KSD ASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASESAQPSEEMKTVLNPEYLEHDAYAVFSQLMETAEPWFSTFEHDGQKGKETLMTPIPFA
100 110 120 130 140 150
290 300 310 320 330 340
pF1KSD RPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPQDLGPTIAIVTKVNQIQDHLLKKHDIELYMHLNRLEIAPQIYGLRWVRLLFGREFPLQ
160 170 180 190 200 210
350 360 370 380 390 400
pF1KSD DLLVVWDALFADGLSLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLLVVWDALFADGLSLGLVDYIFVAMLLYIRDALISSNYQTCLGLLMHYPFIGDVHSLIL
220 230 240 250 260 270
410 420 430 440 450 460
pF1KSD KALFLRDPKRNPRPVTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KALFLRDPKRNPRPVTYQFHPNLDYYKARGADLMNKSRTNAKGAPLNINKVSNSLINFGR
280 290 300 310 320 330
470 480 490 500 510 520
pF1KSD KLISPAMAPGSAGGPVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLISPAMAPGSAGGPVPGGNSSSSSSVVIPTRTSAEAPSHHLQQQQQQQRLMKSESMPVQ
340 350 360 370 380 390
530 540 550 560 570 580
pF1KSD LNKGLSSKNISSSPSVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNKGLSSKNISSSPSVESLPGGREFTGSPPSSATKKDSFFSNISRSRSHSKTMGRKESEE
400 410 420 430 440 450
590 600 610 620 630 640
pF1KSD ELEAQISFLQGQLNDLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELEAQISFLQGQLNDLDAMCKYCAKVMDTHLVNIQDVILQENLEKEDQILVSLAGLKQIK
460 470 480 490 500 510
650 660 670 680 690 700
pF1KSD DILKGSLRFNQSQLEAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DILKGSLRFNQSQLEAEENEQITIADNHYCSSGQGQGRGQGQSVQMSGAIKQASSETPGC
520 530 540 550 560 570
710 720 730 740 750 760
pF1KSD TDRGNSDDFILISKDDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDRGNSDDFILISKDDDGSSARGSFSGQAQPLRTLRSTSGKSQAPVCSPLVFSDPLMGPA
580 590 600 610 620 630
770 780 790
pF1KSD SASSSNPSSSPDDDSSKDSGFTIVSPLDI
:::::::::::::::::::::::::::::
XP_016 SASSSNPSSSPDDDSSKDSGFTIVSPLDI
640 650
795 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Nov 3 00:40:59 2016 done: Thu Nov 3 00:41:00 2016
Total Scan time: 10.280 Total Display time: 0.210
Function used was FASTA [36.3.4 Apr, 2011]