Result of FASTA (omim) for
pFN21AA1378
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KA1378, 620 aa
1>>>pF1KA1378 620 - 620 aa - 620 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2031+/-0.000444; mu= 19.9190+/- 0.027
mean_var=92.7621+/-21.123, 0's: 0 Z-trim(110.5): 294 B-trim: 1591 in 2/54
Lambda= 0.133165
statistics sampled from 18518 (18928) to 18518 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.581), E-opt: 0.2 (0.222), width: 16
Scan time: 8.570
The best scores are: opt bits E(85289)
NP_001278932 (OMIM: 611967) kelch-like protein 8 i ( 620) 4223 822.6 0
NP_065854 (OMIM: 611967) kelch-like protein 8 isof ( 620) 4223 822.6 0
NP_001278935 (OMIM: 611967) kelch-like protein 8 i ( 544) 3259 637.4 4e-182
NP_001278936 (OMIM: 611967) kelch-like protein 8 i ( 437) 2517 494.7 2.8e-139
NP_067646 (OMIM: 614522) kelch-like protein 12 iso ( 568) 1400 280.2 1.3e-74
NP_001289980 (OMIM: 614522) kelch-like protein 12 ( 606) 1400 280.3 1.4e-74
XP_011508137 (OMIM: 614522) PREDICTED: kelch-like ( 623) 1400 280.3 1.4e-74
NP_061990 (OMIM: 300348) kelch-like protein 4 isof ( 718) 1383 277.1 1.5e-73
NP_476503 (OMIM: 300348) kelch-like protein 4 isof ( 720) 1363 273.2 2.1e-72
NP_001244123 (OMIM: 605775,614495) kelch-like prot ( 555) 1313 263.5 1.4e-69
NP_059111 (OMIM: 605775,614495) kelch-like protein ( 587) 1313 263.5 1.5e-69
XP_011529874 (OMIM: 605774) PREDICTED: kelch-like ( 633) 1291 259.3 2.9e-68
NP_001154993 (OMIM: 605774) kelch-like protein 2 i ( 597) 1288 258.7 4.1e-68
XP_016863163 (OMIM: 605774) PREDICTED: kelch-like ( 555) 1287 258.5 4.5e-68
NP_009177 (OMIM: 605774) kelch-like protein 2 isof ( 593) 1287 258.5 4.7e-68
NP_001244124 (OMIM: 605775,614495) kelch-like prot ( 505) 1223 246.2 2.1e-64
XP_016863165 (OMIM: 605774) PREDICTED: kelch-like ( 505) 1176 237.1 1.1e-61
NP_001154994 (OMIM: 605774) kelch-like protein 2 i ( 505) 1176 237.1 1.1e-61
NP_001317953 (OMIM: 605774) kelch-like protein 2 i ( 496) 1101 222.7 2.4e-57
XP_011529878 (OMIM: 605774) PREDICTED: kelch-like ( 496) 1101 222.7 2.4e-57
NP_001290038 (OMIM: 614522) kelch-like protein 12 ( 467) 1083 219.2 2.5e-56
XP_016857484 (OMIM: 614522) PREDICTED: kelch-like ( 471) 1083 219.2 2.5e-56
XP_011508139 (OMIM: 614522) PREDICTED: kelch-like ( 522) 1083 219.3 2.7e-56
XP_011508138 (OMIM: 614522) PREDICTED: kelch-like ( 526) 1083 219.3 2.7e-56
NP_987096 (OMIM: 606016) kelch-like ECH-associated ( 624) 1047 212.5 3.7e-54
XP_005260230 (OMIM: 606016) PREDICTED: kelch-like ( 624) 1047 212.5 3.7e-54
NP_036421 (OMIM: 606016) kelch-like ECH-associated ( 624) 1047 212.5 3.7e-54
XP_011526754 (OMIM: 606016) PREDICTED: kelch-like ( 624) 1047 212.5 3.7e-54
XP_005260231 (OMIM: 606016) PREDICTED: kelch-like ( 624) 1047 212.5 3.7e-54
NP_001316524 (OMIM: 608778,615081) kelch-like prot ( 608) 1002 203.8 1.4e-51
NP_689680 (OMIM: 608778,615081) kelch-like protein ( 608) 1002 203.8 1.4e-51
XP_016863164 (OMIM: 605774) PREDICTED: kelch-like ( 415) 947 193.1 1.7e-48
NP_001317952 (OMIM: 605774) kelch-like protein 2 i ( 427) 946 192.9 2e-48
NP_001316525 (OMIM: 608778,615081) kelch-like prot ( 520) 893 182.8 2.6e-45
XP_016856699 (OMIM: 147485) PREDICTED: actin-bindi ( 531) 860 176.5 2.1e-43
NP_001138821 (OMIM: 147485) actin-binding protein ( 582) 860 176.5 2.3e-43
NP_005888 (OMIM: 147485) actin-binding protein IPP ( 584) 860 176.5 2.3e-43
NP_001026880 (OMIM: 611119,612943,617055) kelch-li ( 586) 823 169.4 3.2e-41
XP_016867928 (OMIM: 611119,612943,617055) PREDICTE ( 564) 815 167.8 8.9e-41
NP_061334 (OMIM: 611119,612943,617055) kelch-like ( 538) 782 161.5 7e-39
NP_569713 (OMIM: 614214) kelch-like protein 6 [Hom ( 621) 741 153.7 1.8e-36
XP_011541998 (OMIM: 605173) PREDICTED: ectoderm-ne ( 589) 737 152.9 3e-36
XP_011541999 (OMIM: 605173) PREDICTED: ectoderm-ne ( 589) 737 152.9 3e-36
NP_001243504 (OMIM: 605173) ectoderm-neural cortex ( 589) 737 152.9 3e-36
NP_003624 (OMIM: 605173) ectoderm-neural cortex pr ( 589) 737 152.9 3e-36
NP_001243503 (OMIM: 605173) ectoderm-neural cortex ( 589) 737 152.9 3e-36
XP_006710686 (OMIM: 147485) PREDICTED: actin-bindi ( 440) 719 149.3 2.7e-35
XP_005270896 (OMIM: 147485) PREDICTED: actin-bindi ( 465) 717 148.9 3.6e-35
XP_011539696 (OMIM: 147485) PREDICTED: actin-bindi ( 465) 717 148.9 3.6e-35
XP_005247613 (OMIM: 611295) PREDICTED: kelch-like ( 600) 715 148.7 5.7e-35
>>NP_001278932 (OMIM: 611967) kelch-like protein 8 isofo (620 aa)
initn: 4223 init1: 4223 opt: 4223 Z-score: 4391.0 bits: 822.6 E(85289): 0
Smith-Waterman score: 4223; 100.0% identity (100.0% similar) in 620 aa overlap (1-620:1-620)
10 20 30 40 50 60
pF1KA1 MASDSMSSKQARNHITKGKRQQQHQQIKNRSSISDGDGEDSFIFEANEAWKDFHGSLLRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MASDSMSSKQARNHITKGKRQQQHQQIKNRSSISDGDGEDSFIFEANEAWKDFHGSLLRF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 YENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIED
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 LVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 RIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 NPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 VPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 VISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 LDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 DPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAAL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 TTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVCS
550 560 570 580 590 600
610 620
pF1KA1 CLTSQIRDVGHGSNNVVDCM
::::::::::::::::::::
NP_001 CLTSQIRDVGHGSNNVVDCM
610 620
>>NP_065854 (OMIM: 611967) kelch-like protein 8 isoform (620 aa)
initn: 4223 init1: 4223 opt: 4223 Z-score: 4391.0 bits: 822.6 E(85289): 0
Smith-Waterman score: 4223; 100.0% identity (100.0% similar) in 620 aa overlap (1-620:1-620)
10 20 30 40 50 60
pF1KA1 MASDSMSSKQARNHITKGKRQQQHQQIKNRSSISDGDGEDSFIFEANEAWKDFHGSLLRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 MASDSMSSKQARNHITKGKRQQQHQQIKNRSSISDGDGEDSFIFEANEAWKDFHGSLLRF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 YENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 YENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIED
70 80 90 100 110 120
130 140 150 160 170 180
pF1KA1 LVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KA1 RIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 RIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KA1 NPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 NPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KA1 VPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 VPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KA1 VISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 VISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KA1 LDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 LDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERY
430 440 450 460 470 480
490 500 510 520 530 540
pF1KA1 DPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 DPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAAL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KA1 TTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_065 TTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVCS
550 560 570 580 590 600
610 620
pF1KA1 CLTSQIRDVGHGSNNVVDCM
::::::::::::::::::::
NP_065 CLTSQIRDVGHGSNNVVDCM
610 620
>>NP_001278935 (OMIM: 611967) kelch-like protein 8 isofo (544 aa)
initn: 3259 init1: 3259 opt: 3259 Z-score: 3390.8 bits: 637.4 E(85289): 4e-182
Smith-Waterman score: 3574; 87.7% identity (87.7% similar) in 620 aa overlap (1-620:1-544)
10 20 30 40 50 60
pF1KA1 MASDSMSSKQARNHITKGKRQQQHQQIKNRSSISDGDGEDSFIFEANEAWKDFHGSLLRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MASDSMSSKQARNHITKGKRQQQHQQIKNRSSISDGDGEDSFIFEANEAWKDFHGSLLRF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 YENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIED
:::::::::::::
NP_001 YENGELCDVTLKV-----------------------------------------------
70
130 140 150 160 170 180
pF1KA1 LVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHN
:::::::::::::::::::::::::::::::
NP_001 -----------------------------ELVARACCEYMKLHFHPSNCLAVRAFAESHN
80 90 100
190 200 210 220 230 240
pF1KA1 RIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLA
110 120 130 140 150 160
250 260 270 280 290 300
pF1KA1 NPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRA
170 180 190 200 210 220
310 320 330 340 350 360
pF1KA1 VPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVG
230 240 250 260 270 280
370 380 390 400 410 420
pF1KA1 VISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGG
290 300 310 320 330 340
430 440 450 460 470 480
pF1KA1 LDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERY
350 360 370 380 390 400
490 500 510 520 530 540
pF1KA1 DPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAAL
410 420 430 440 450 460
550 560 570 580 590 600
pF1KA1 TTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVCS
470 480 490 500 510 520
610 620
pF1KA1 CLTSQIRDVGHGSNNVVDCM
::::::::::::::::::::
NP_001 CLTSQIRDVGHGSNNVVDCM
530 540
>>NP_001278936 (OMIM: 611967) kelch-like protein 8 isofo (437 aa)
initn: 2514 init1: 2514 opt: 2517 Z-score: 2621.6 bits: 494.7 E(85289): 2.8e-139
Smith-Waterman score: 2620; 70.5% identity (70.5% similar) in 620 aa overlap (1-620:1-437)
10 20 30 40 50 60
pF1KA1 MASDSMSSKQARNHITKGKRQQQHQQIKNRSSISDGDGEDSFIFEANEAWKDFHGSLLRF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MASDSMSSKQARNHITKGKRQQQHQQIKNRSSISDGDGEDSFIFEANEAWKDFHGSLLRF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KA1 YENGELCDVTLKVGSKLISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIED
:::::::::::::
NP_001 YENGELCDVTLKV-----------------------------------------------
70
130 140 150 160 170 180
pF1KA1 LVKFVYSSRLTLTVDNVQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHN
NP_001 ------------------------------------------------------------
190 200 210 220 230 240
pF1KA1 RIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLA
NP_001 ------------------------------------------------------------
250 260 270 280 290 300
pF1KA1 NPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRA
::::::::::::::::::::::::::::::::::::::::::::
NP_001 ----------------RLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRA
80 90 100 110
310 320 330 340 350 360
pF1KA1 VPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVG
120 130 140 150 160 170
370 380 390 400 410 420
pF1KA1 VISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMMKASMNTKRRGIALASLGGPIYAIGG
180 190 200 210 220 230
430 440 450 460 470 480
pF1KA1 LDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERY
240 250 260 270 280 290
490 500 510 520 530 540
pF1KA1 DPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAAL
300 310 320 330 340 350
550 560 570 580 590 600
pF1KA1 TTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTPRGGVGIATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVCS
360 370 380 390 400 410
610 620
pF1KA1 CLTSQIRDVGHGSNNVVDCM
::::::::::::::::::::
NP_001 CLTSQIRDVGHGSNNVVDCM
420 430
>>NP_067646 (OMIM: 614522) kelch-like protein 12 isoform (568 aa)
initn: 1660 init1: 1155 opt: 1400 Z-score: 1460.4 bits: 280.2 E(85289): 1.3e-74
Smith-Waterman score: 1400; 38.5% identity (71.0% similar) in 559 aa overlap (47-598:13-564)
20 30 40 50 60 70
pF1KA1 KGKRQQQHQQIKNRSSISDGDGEDSFIFEANEAWKDFHGSLLRFYENGELCDVTLKVGSK
: :.. .:. . ... ::::::.: .:
NP_067 MGGIMAPKDIMTNTHAKSILNSMNSLRKSNTLCDVTLRVEQK
10 20 30 40
80 90 100 110 120 130
pF1KA1 LISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDN
. :..::: :: ::: ::..: . ..:. . ....: :. :::. . .::.:
NP_067 DFPAHRIVLAACSDYFCAMFTSELSEKGKPYVDIQGLTASTMEILLDFVYTETVHVTVEN
50 60 70 80 90 100
140 150 160 170 180 190
pF1KA1 VQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHF
:: :: :::.::.. : .::::... .. :::::..: :::.:: .:::. :. .. ::
NP_067 VQELLPAACLLQLKGVKQACCEFLESQLDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHF
110 120 130 140 150 160
200 210 220 230 240 250
pF1KA1 TEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQV
:::. :.:. .: ...::.. .......:. :..:.:.:. ... . : . : :
NP_067 PEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPVFEAVINWVKHAKKEREESLPNLLQYV
170 180 190 200 210 220
260 270 280 290 300 310
pF1KA1 RLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRAVPDFEYSI---RTTPR
:.::: .. :. : ... .:.::::.:::...::. :... .. :: :
NP_067 RMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEAKKFHLR------PELRSQMQGPRTRAR
230 240 250 260 270
320 330 340 350 360 370
pF1KA1 KHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGG
. ::. ::: :.. .:. .: :. . . : : : .. .::.:. .:.. ..:..::
NP_067 LGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGG
280 290 300 310 320 330
380 390 400 410 420
pF1KA1 HDGNEHLGSMEMFDPLTNK---WMMKASMNTKRRGIALAS-LGGPIYAIGGLDDNTCFND
.:: .:.:.: .: ... :. : ::. :::.: :. :: ::. ::.: . ..
NP_067 YDGRSRLSSVECLDYTADEDGVWYSVAPMNV-RRGLAGATTLGDMIYVSGGFDGSRRHTS
340 350 360 370 380 390
430 440 450 460 470 480
pF1KA1 VERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIE
.:::: . :::: .. :.: : :.: :. . .: .:: ::. :.:::.:::: .: .
NP_067 MERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTN
400 410 420 430 440 450
490 500 510 520 530 540
pF1KA1 VKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGI
: :. .:.: ::. :. .::::::: .. ::::: :. :...: :...:::: ::
NP_067 VTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGA
460 470 480 490 500 510
550 560 570 580 590 600
pF1KA1 ATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVCSCLTSQIRDV
... :...:..:..::. :...: .::... ::.: :.. : ::: :
NP_067 TVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQRCDAGVCVLREK
520 530 540 550 560
610 620
pF1KA1 GHGSNNVVDCM
>>NP_001289980 (OMIM: 614522) kelch-like protein 12 isof (606 aa)
initn: 1660 init1: 1155 opt: 1400 Z-score: 1460.0 bits: 280.3 E(85289): 1.4e-74
Smith-Waterman score: 1400; 38.5% identity (71.0% similar) in 559 aa overlap (47-598:51-602)
20 30 40 50 60 70
pF1KA1 KGKRQQQHQQIKNRSSISDGDGEDSFIFEANEAWKDFHGSLLRFYENGELCDVTLKVGSK
: :.. .:. . ... ::::::.: .:
NP_001 TWKLQNPRTHFVLSPHCFMGGIMAPKDIMTNTHAKSILNSMNSLRKSNTLCDVTLRVEQK
30 40 50 60 70 80
80 90 100 110 120 130
pF1KA1 LISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDN
. :..::: :: ::: ::..: . ..:. . ....: :. :::. . .::.:
NP_001 DFPAHRIVLAACSDYFCAMFTSELSEKGKPYVDIQGLTASTMEILLDFVYTETVHVTVEN
90 100 110 120 130 140
140 150 160 170 180 190
pF1KA1 VQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHF
:: :: :::.::.. : .::::... .. :::::..: :::.:: .:::. :. .. ::
NP_001 VQELLPAACLLQLKGVKQACCEFLESQLDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHF
150 160 170 180 190 200
200 210 220 230 240 250
pF1KA1 TEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQV
:::. :.:. .: ...::.. .......:. :..:.:.:. ... . : . : :
NP_001 PEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPVFEAVINWVKHAKKEREESLPNLLQYV
210 220 230 240 250 260
260 270 280 290 300 310
pF1KA1 RLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRAVPDFEYSI---RTTPR
:.::: .. :. : ... .:.::::.:::...::. :... .. :: :
NP_001 RMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEAKKFHLR------PELRSQMQGPRTRAR
270 280 290 300 310
320 330 340 350 360 370
pF1KA1 KHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGG
. ::. ::: :.. .:. .: :. . . : : : .. .::.:. .:.. ..:..::
NP_001 LGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGG
320 330 340 350 360 370
380 390 400 410 420
pF1KA1 HDGNEHLGSMEMFDPLTNK---WMMKASMNTKRRGIALAS-LGGPIYAIGGLDDNTCFND
.:: .:.:.: .: ... :. : ::. :::.: :. :: ::. ::.: . ..
NP_001 YDGRSRLSSVECLDYTADEDGVWYSVAPMNV-RRGLAGATTLGDMIYVSGGFDGSRRHTS
380 390 400 410 420 430
430 440 450 460 470 480
pF1KA1 VERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIE
.:::: . :::: .. :.: : :.: :. . .: .:: ::. :.:::.:::: .: .
NP_001 MERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTN
440 450 460 470 480 490
490 500 510 520 530 540
pF1KA1 VKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGI
: :. .:.: ::. :. .::::::: .. ::::: :. :...: :...:::: ::
NP_001 VTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGA
500 510 520 530 540 550
550 560 570 580 590 600
pF1KA1 ATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVCSCLTSQIRDV
... :...:..:..::. :...: .::... ::.: :.. : ::: :
NP_001 TVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQRCDAGVCVLREK
560 570 580 590 600
610 620
pF1KA1 GHGSNNVVDCM
>>XP_011508137 (OMIM: 614522) PREDICTED: kelch-like prot (623 aa)
initn: 1660 init1: 1155 opt: 1400 Z-score: 1459.9 bits: 280.3 E(85289): 1.4e-74
Smith-Waterman score: 1400; 38.5% identity (71.0% similar) in 559 aa overlap (47-598:68-619)
20 30 40 50 60 70
pF1KA1 KGKRQQQHQQIKNRSSISDGDGEDSFIFEANEAWKDFHGSLLRFYENGELCDVTLKVGSK
: :.. .:. . ... ::::::.: .:
XP_011 GAQLQNPRTHFVLSPHCFMGGIMAPKDIMTNTHAKSILNSMNSLRKSNTLCDVTLRVEQK
40 50 60 70 80 90
80 90 100 110 120 130
pF1KA1 LISCHKLVLACVIPYFRAMFLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDN
. :..::: :: ::: ::..: . ..:. . ....: :. :::. . .::.:
XP_011 DFPAHRIVLAACSDYFCAMFTSELSEKGKPYVDIQGLTASTMEILLDFVYTETVHVTVEN
100 110 120 130 140 150
140 150 160 170 180 190
pF1KA1 VQPLLYAACILQVELVARACCEYMKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHF
:: :: :::.::.. : .::::... .. :::::..: :::.:: .:::. :. .. ::
XP_011 VQELLPAACLLQLKGVKQACCEFLESQLDPSNCLGIRDFAETHNCVDLMQAAEVFSQKHF
160 170 180 190 200 210
200 210 220 230 240 250
pF1KA1 TEVVECEDFVSVSPQHLHKLLSSSDLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQV
:::. :.:. .: ...::.. .......:. :..:.:.:. ... . : . : :
XP_011 PEVVQHEEFILLSQGEVEKLIKCDEIQVDSEEPVFEAVINWVKHAKKEREESLPNLLQYV
220 230 240 250 260 270
260 270 280 290 300 310
pF1KA1 RLPLLPVDFLMGVVAKEQIVKQNLKCRDLLDEARNYHLHLSSRAVPDFEYSI---RTTPR
:.::: .. :. : ... .:.::::.:::...::. :... .. :: :
XP_011 RMPLLTPRYITDVIDAEPFIRCSLQCRDLVDEAKKFHLR------PELRSQMQGPRTRAR
280 290 300 310 320 330
320 330 340 350 360 370
pF1KA1 KHTAGVLFCVGGRGGSGDPFRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGG
. ::. ::: :.. .:. .: :. . . : : : .. .::.:. .:.. ..:..::
XP_011 LGANEVLLVVGGFGSQQSPIDVVEKYDPKTQEWSFLPSITRKRRYVASVSLHDRIYVIGG
340 350 360 370 380 390
380 390 400 410 420
pF1KA1 HDGNEHLGSMEMFDPLTNK---WMMKASMNTKRRGIALAS-LGGPIYAIGGLDDNTCFND
.:: .:.:.: .: ... :. : ::. :::.: :. :: ::. ::.: . ..
XP_011 YDGRSRLSSVECLDYTADEDGVWYSVAPMNV-RRGLAGATTLGDMIYVSGGFDGSRRHTS
400 410 420 430 440 450
430 440 450 460 470 480
pF1KA1 VERYDIESDQWSTVAPMNTPRGGVGSVALVNHVYAVGGNDGMASLSSVERYDPHLDKWIE
.:::: . :::: .. :.: : :.: :. . .: .:: ::. :.:::.:::: .: .
XP_011 MERYDPNIDQWSMLGDMQTAREGAGLVVASGVIYCLGGYDGLNILNSVEKYDPHTGHWTN
460 470 480 490 500 510
490 500 510 520 530 540
pF1KA1 VKEMGQRRAGNGVSKLHGCLYVVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGI
: :. .:.: ::. :. .::::::: .. ::::: :. :...: :...:::: ::
XP_011 VTPMATKRSGAGVALLNDHIYVVGGFDGTAHLSSVEAYNIRTDSWTTVTSMTTPRCYVGA
520 530 540 550 560 570
550 560 570 580 590 600
pF1KA1 ATVMGKIFAVGGHNGNAYLNTVEAFDPVLNRWELVGSVSHCRAGAGVAVCSCLTSQIRDV
... :...:..:..::. :...: .::... ::.: :.. : ::: :
XP_011 TVLRGRLYAIAGYDGNSLLSSIECYDPIIDSWEVVTSMGTQRCDAGVCVLREK
580 590 600 610 620
610 620
pF1KA1 GHGSNNVVDCM
>>NP_061990 (OMIM: 300348) kelch-like protein 4 isoform (718 aa)
initn: 2013 init1: 580 opt: 1383 Z-score: 1441.5 bits: 277.1 E(85289): 1.5e-73
Smith-Waterman score: 1383; 38.7% identity (69.1% similar) in 599 aa overlap (19-598:122-714)
10 20 30 40
pF1KA1 MASDSMSSKQARNHITKGKRQQQHQQIKNRSSISDG----DGEDSFIF
:: :. ... . ..: :. : . : .
NP_061 QQHNLIVHFQANEDTPKSVPEKNLFKEACEKRAQDLEMMAD-DNIEDSTARLDTQHSEDM
100 110 120 130 140 150
50 60 70 80 90
pF1KA1 EANEAWKDFH-----GSLLRFYEN----GELCDVTLKVGSKLISCHKLVLACVIPYFRAM
.:... ..:: . :: .:: .:::: : .: : :.:::. : :: ::
NP_061 NATRSEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAM
160 170 180 190 200 210
100 110 120 130 140 150
pF1KA1 FLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARA
: ... :::: .... : .:...::...:.. : : :... :: :::.::. : .
NP_061 FTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDV
220 230 240 250 260 270
160 170 180 190 200 210
pF1KA1 CCEYMKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHK
: ... ..::::::..:.:..... .:...: .:. .:: ::.. ..:. . ... :
NP_061 CSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISK
280 290 300 310 320 330
220 230 240 250 260 270
pF1KA1 LLSSSDLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQI
:: :.:.:. .:. ...: ..:. . :... : :. .:::::: . :.. . ..
NP_061 LLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQ-LLADLETSSM
340 350 360 370 380
280 290 300 310 320 330
pF1KA1 VKQNLKCRDLLDEARNYHLHLSSRAVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRS
.:.:. :: :: .::: :.. . : :: ::: :.:.:. ::: . .
NP_061 FTGDLECQKLLMEAMKYHLLPERRSMMQ---SPRTKPRKSTVGALYAVGGMDAMKGT-TT
390 400 410 420 430 440
340 350 360 370 380 390
pF1KA1 IECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMM
:: :.. :::. ::.:: . :: ...:.:.:::.:: . :...: :.:. . : .
NP_061 IEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTV
450 460 470 480 490 500
400 410 420 430 440 450
pF1KA1 KASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGS
:.:.:.:...:.: ::.::.:: : . .: :::.: :. ::. :: :.:::. ::
NP_061 MPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGV
510 520 530 540 550 560
460 470 480 490 500 510
pF1KA1 VALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGF
::: :..::.:: :: . :.:.: .::: .:: :..::.: ::. .: ::::::
NP_061 VALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGH
570 580 590 600 610 620
520 530 540 550 560
pF1KA1 D---DN--SPLSS-VERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLN
: .: : ::. ::::::....:. :: :..:: .:.. . :...:::..:..:::
NP_061 DAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLN
630 640 650 660 670 680
570 580 590 600 610 620
pF1KA1 TVEAFDPVLNRWELVGSVSHCRAGAGVAVCSCLTSQIRDVGHGSNNVVDCM
:::..: :.:. :. :::: :.:
NP_061 TVESYDAQRNEWKEEVPVNIGRAGACVVVVKLP
690 700 710
>>NP_476503 (OMIM: 300348) kelch-like protein 4 isoform (720 aa)
initn: 1977 init1: 580 opt: 1363 Z-score: 1420.7 bits: 273.2 E(85289): 2.1e-72
Smith-Waterman score: 1363; 38.6% identity (69.1% similar) in 583 aa overlap (19-582:122-698)
10 20 30 40
pF1KA1 MASDSMSSKQARNHITKGKRQQQHQQIKNRSSISDG----DGEDSFIF
:: :. ... . ..: :. : . : .
NP_476 QQHNLIVHFQANEDTPKSVPEKNLFKEACEKRAQDLEMMAD-DNIEDSTARLDTQHSEDM
100 110 120 130 140 150
50 60 70 80 90
pF1KA1 EANEAWKDFH-----GSLLRFYEN----GELCDVTLKVGSKLISCHKLVLACVIPYFRAM
.:... ..:: . :: .:: .:::: : .: : :.:::. : :: ::
NP_476 NATRSEEQFHVINHAEQTLRKMENYLKEKQLCDVLLIAGHLRIPAHRLVLSAVSDYFAAM
160 170 180 190 200 210
100 110 120 130 140 150
pF1KA1 FLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARA
: ... :::: .... : .:...::...:.. : : :... :: :::.::. : .
NP_476 FTNDVLEAKQEEVRMEGVDPNALNSLVQYAYTGVLQLKEDTIESLLAAACLLQLTQVIDV
220 230 240 250 260 270
160 170 180 190 200 210
pF1KA1 CCEYMKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHK
: ... ..::::::..:.:..... .:...: .:. .:: ::.. ..:. . ... :
NP_476 CSNFLIKQLHPSNCLGIRSFGDAQGCTELLNVAHKYTMEHFIEVIKNQEFLLLPANEISK
280 290 300 310 320 330
220 230 240 250 260 270
pF1KA1 LLSSSDLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQI
:: :.:.:. .:. ...: ..:. . :... : :. .:::::: ..: . ..
NP_476 LLCSDDINVPDEETIFHALMQWVGHDVQNRQGELGMLLSYIRLPLLPPQLLADL-ETSSM
340 350 360 370 380
280 290 300 310 320 330
pF1KA1 VKQNLKCRDLLDEARNYHLHLSSRAVPDFEYSIRTTPRKHTAGVLFCVGGRGGSGDPFRS
.:.:. :: :: .::: :.. : :: ::: :.:.:. ::: . .
NP_476 FTGDLECQKLLMEAMKYHLLPERRSM---MQSPRTKPRKSTVGALYAVGGMDAMKGT-TT
390 400 410 420 430 440
340 350 360 370 380 390
pF1KA1 IECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNKWMM
:: :.. :::. ::.:: . :: ...:.:.:::.:: . :...: :.:. . : .
NP_476 IEKYDLRTNSWLHIGTMNGRRLQFGVAVIDNKLYVVGGRDGLKTLNTVECFNPVGKIWTV
450 460 470 480 490 500
400 410 420 430 440 450
pF1KA1 KASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGGVGS
:.:.:.:...:.: ::.::.:: : . .: :::.: :. ::. :: :.:::. ::
NP_476 MPPMSTHRHGLGVATLEGPMYAVGGHDGWSYLNTVERWDPEGRQWNYVASMSTPRSTVGV
510 520 530 540 550 560
460 470 480 490 500 510
pF1KA1 VALVNHVYAVGGNDGMASLSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLYVVGGF
::: :..::.:: :: . :.:.: .::: .:: :..::.: ::. .: ::::::
NP_476 VALNNKLYAIGGRDGSSCLKSMEYFDPHTNKWSLCAPMSKRRGGVGVATYNGFLYVVGGH
570 580 590 600 610 620
520 530 540 550 560
pF1KA1 D---DN--SPLSS-VERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLN
: .: : ::. ::::::....:. :: :..:: .:.. . :...:::..:..:::
NP_476 DAPASNHCSRLSDCVERYDPKGDSWSTVAPLSVPRDAVAVCPLGDKLYVVGGYDGHTYLN
630 640 650 660 670 680
570 580 590 600 610 620
pF1KA1 TVEAFDPVLNRWELVGSVSHCRAGAGVAVCSCLTSQIRDVGHGSNNVVDCM
:::..: :.:.
NP_476 TVESYDAQRNEWKESMQELLQNFYTTQKLKETLGH
690 700 710 720
>>NP_001244123 (OMIM: 605775,614495) kelch-like protein (555 aa)
initn: 1148 init1: 777 opt: 1313 Z-score: 1370.2 bits: 263.5 E(85289): 1.4e-69
Smith-Waterman score: 1313; 39.0% identity (71.1% similar) in 539 aa overlap (66-598:17-550)
40 50 60 70 80 90
pF1KA1 GDGEDSFIFEANEAWKDFHGSLLRFYENGELCDVTLKVGSKLISCHKLVLACVIPYFRAM
:::: . . . : :..::: ::: ::
NP_001 MGKAFKVMNELRSKQLLCDVMIVAEDVEIEAHRVVLAACSPYFCAM
10 20 30 40
100 110 120 130 140 150
pF1KA1 FLSEMAEAKQTLIEIRDFDGDAIEDLVKFVYSSRLTLTVDNVQPLLYAACILQVELVARA
: ..:.:.: :::.: ::... :. ..:.... .: .::: :: :: .::. : .
NP_001 FTGDMSESKAKKIEIKDVDGQTLSKLIDYIYTAEIEVTEENVQVLLPAASLLQLMDVRQN
50 60 70 80 90 100
160 170 180 190 200 210
pF1KA1 CCEYMKLHFHPSNCLAVRAFAESHNRIDLMDMADQYACDHFTEVVECEDFVSVSPQHLHK
::.... ..::.:::..::::. :. ::...:. :: .:: ::. :.:.:.: ... .
NP_001 CCDFLQSQLHPTNCLGIRAFADVHTCTDLLQQANAYAEQHFPEVMLGEEFLSLSLDQVCS
110 120 130 140 150 160
220 230 240 250 260 270
pF1KA1 LLSSSDLNIENEKQVYNAAIKWLLANPQHHSKWLDETLAQVRLPLLPVDFLMGVVAKEQI
:.::. :.. .:..:..:.:.:. . . . . . . . .::::::: :.:. .: .: .
NP_001 LISSDKLTVSSEEKVFEAVISWINYEKETRLEHMAKLMEHVRLPLLPRDYLVQTVEEEAL
170 180 190 200 210 220
280 290 300 310 320 330
pF1KA1 VKQNLKCRDLLDEARNYHL-HLSSRAVPDFEYSIRTTPRKHTA--GVLFCVGGRGGSGDP
.:.: :.:.: :: .::: :..: . . :: :: .. :.. :::.. ..
NP_001 IKNNNTCKDFLIEAMKYHLLPLDQRLLIK---NPRTKPRTPVSLPKVMIVVGGQAPKA--
230 240 250 260 270 280
340 350 360 370 380 390
pF1KA1 FRSIECYSINKNSWFFGPEMNSRRRHVGVISVEGKVYAVGGHDGNEHLGSMEMFDPLTNK
.::.:::..... : :. ::: ..::. . :.:::::: .:. .. .....: . ..
NP_001 IRSVECYDFEEDRWDQIAELPSRRCRAGVVFMAGHVYAVGGFNGSLRVRTVDVYDGVKDQ
290 300 310 320 330 340
400 410 420 430 440 450
pF1KA1 WMMKASMNTKRRGIALASLGGPIYAIGGLDDNTCFNDVERYDIESDQWSTVAPMNTPRGG
: :::. .: .. : :. .::.::.: .: . .:: :. ....: :::::: :..
NP_001 WTSIASMQERRSTLGAAVLNDLLYAVGGFDGSTGLASVEAYSYKTNEWFFVAPMNTRRSS
350 360 370 380 390 400
460 470 480 490 500 510
pF1KA1 VGSVALVNHVYAVGGNDGMAS--LSSVERYDPHLDKWIEVKEMGQRRAGNGVSKLHGCLY
:: .. ...::::: :: . ::.::.:.: ..:: : .:. ::.: ::. : : ::
NP_001 VGVGVVEGKLYAVGGYDGASRQCLSTVEQYNPATNEWIYVADMSTRRSGAGVGVLSGQLY
410 420 430 440 450 460
520 530 540 550 560 570
pF1KA1 VVGGFDDNSPLSSVERYDPRSNKWDYVAALTTPRGGVGIATVMGKIFAVGGHNGNAYLNT
..:: : .::: ::: .: : :: .. : ..:. .: : ...::: .:. : .
NP_001 ATGGHDGPLVRKSVEVYDPGTNTWKQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLAS
470 480 490 500 510 520
580 590 600 610 620
pF1KA1 VEAFDPVLNRWELVGS-VSHCRAGAGVAVCSCLTSQIRDVGHGSNNVVDCM
:: ..:: ..: :. . .: :. :::::
NP_001 VEYYNPVTDKWTLLPTNMSTGRSYAGVAVIHKSL
530 540 550
620 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 2 21:06:13 2016 done: Wed Nov 2 21:06:15 2016
Total Scan time: 8.570 Total Display time: 0.100
Function used was FASTA [36.3.4 Apr, 2011]