Result of FASTA (omim) for
pFN21AE9659
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE9659, 222 aa
1>>>pF1KE9659 222 - 222 aa - 222 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.0495+/-0.000365; mu= 7.2993+/- 0.023
mean_var=131.6675+/-26.865, 0's: 0 Z-trim(116.9): 18 B-trim: 385 in 1/53
Lambda= 0.111772
statistics sampled from 28348 (28366) to 28348 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.673), E-opt: 0.2 (0.333), width: 16
Scan time: 4.410
The best scores are: opt bits E(85289)
NP_055268 (OMIM: 610893) charged multivesicular bo ( 222) 1379 233.1 2.9e-61
NP_940818 (OMIM: 610893) charged multivesicular bo ( 222) 1379 233.1 2.9e-61
XP_005258804 (OMIM: 610893) PREDICTED: charged mul ( 265) 1125 192.2 7.2e-49
XP_005258803 (OMIM: 610893) PREDICTED: charged mul ( 265) 1125 192.2 7.2e-49
NP_054762 (OMIM: 600795,609512,614696) charged mul ( 213) 427 79.5 4.6e-15
XP_011531878 (OMIM: 600795,609512,614696) PREDICTE ( 229) 408 76.5 4.1e-14
NP_001231573 (OMIM: 600795,609512,614696) charged ( 172) 346 66.4 3.3e-11
NP_057163 (OMIM: 610052) charged multivesicular bo ( 222) 308 60.4 2.8e-09
NP_065145 (OMIM: 606486) charged multivesicular bo ( 199) 296 58.4 1e-08
NP_002759 (OMIM: 164010,614961) charged multivesic ( 196) 258 52.3 6.9e-07
NP_001180446 (OMIM: 610052) charged multivesicular ( 182) 198 42.6 0.00053
NP_057494 (OMIM: 610900) charged multivesicular bo ( 219) 188 41.0 0.0019
NP_001005753 (OMIM: 610052) charged multivesicular ( 156) 175 38.8 0.0062
>>NP_055268 (OMIM: 610893) charged multivesicular body p (222 aa)
initn: 1379 init1: 1379 opt: 1379 Z-score: 1220.8 bits: 233.1 E(85289): 2.9e-61
Smith-Waterman score: 1379; 100.0% identity (100.0% similar) in 222 aa overlap (1-222:1-222)
10 20 30 40 50 60
pF1KE9 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS
130 140 150 160 170 180
190 200 210 220
pF1KE9 NLPSTGGSLSVAAGGKKAEAAASALADADADLEERLKNLRRD
::::::::::::::::::::::::::::::::::::::::::
NP_055 NLPSTGGSLSVAAGGKKAEAAASALADADADLEERLKNLRRD
190 200 210 220
>>NP_940818 (OMIM: 610893) charged multivesicular body p (222 aa)
initn: 1379 init1: 1379 opt: 1379 Z-score: 1220.8 bits: 233.1 E(85289): 2.9e-61
Smith-Waterman score: 1379; 100.0% identity (100.0% similar) in 222 aa overlap (1-222:1-222)
10 20 30 40 50 60
pF1KE9 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_940 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS
130 140 150 160 170 180
190 200 210 220
pF1KE9 NLPSTGGSLSVAAGGKKAEAAASALADADADLEERLKNLRRD
::::::::::::::::::::::::::::::::::::::::::
NP_940 NLPSTGGSLSVAAGGKKAEAAASALADADADLEERLKNLRRD
190 200 210 220
>>XP_005258804 (OMIM: 610893) PREDICTED: charged multive (265 aa)
initn: 1206 init1: 1125 opt: 1125 Z-score: 998.4 bits: 192.2 E(85289): 7.2e-49
Smith-Waterman score: 1209; 82.7% identity (83.1% similar) in 254 aa overlap (1-211:1-254)
10 20 30 40 50 60
pF1KE9 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS
130 140 150 160 170 180
190
pF1KE9 -------------------------------------------NLPSTGGSLSVAAGGKK
.::::::::::::::::
XP_005 SECSKSWTPFPTQGPATAPSPPFPCITPLRCLTPPAQTPTFSADLPSTGGSLSVAAGGKK
190 200 210 220 230 240
200 210 220
pF1KE9 AEAAASALADADADLEERLKNLRRD
::::::::::::::
XP_005 AEAAASALADADADLEERLKNLRRD
250 260
>>XP_005258803 (OMIM: 610893) PREDICTED: charged multive (265 aa)
initn: 1206 init1: 1125 opt: 1125 Z-score: 998.4 bits: 192.2 E(85289): 7.2e-49
Smith-Waterman score: 1209; 82.7% identity (83.1% similar) in 254 aa overlap (1-211:1-254)
10 20 30 40 50 60
pF1KE9 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS
130 140 150 160 170 180
190
pF1KE9 -------------------------------------------NLPSTGGSLSVAAGGKK
.::::::::::::::::
XP_005 SECSKSWTPFPTQGPATAPSPPFPCITPLRCLTPPAQTPTFSADLPSTGGSLSVAAGGKK
190 200 210 220 230 240
200 210 220
pF1KE9 AEAAASALADADADLEERLKNLRRD
::::::::::::::
XP_005 AEAAASALADADADLEERLKNLRRD
250 260
>>NP_054762 (OMIM: 600795,609512,614696) charged multive (213 aa)
initn: 482 init1: 365 opt: 427 Z-score: 391.4 bits: 79.5 E(85289): 4.6e-15
Smith-Waterman score: 427; 33.3% identity (69.8% similar) in 222 aa overlap (1-222:1-213)
10 20 30 40 50 60
pF1KE9 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR
: :: ..:: ........: : ..: . :.: :: :::.. .:::::: :. .: .
NP_054 MASLF-KKKTVDDVIKEQNRELRGTQRAIIRDRAALEKQEKQLELEIKKMAKIGNKEACK
10 20 30 40 50
70 80 90 100 110 120
pF1KE9 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP
..::.::. :. . . ... ..: . ....:. .:: ::. ..:.: ..:...
NP_054 VLAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQ
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE9 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS
. . :..:... :.: :::.::..:: . .:::::. .:.:::::.:. .. ...
NP_054 KTLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMA
120 130 140 150 160 170
190 200 210 220
pF1KE9 NLPSTGGSLSVAAGGKKAEAAASALADADADLEERLKNLRRD
. ::.. :: :. .: :. : : ..:..:: : :
NP_054 KAPSAARSLPSASTSK---ATIS-----DEEIERQLKALGVD
180 190 200 210
>>XP_011531878 (OMIM: 600795,609512,614696) PREDICTED: c (229 aa)
initn: 482 init1: 365 opt: 408 Z-score: 374.4 bits: 76.5 E(85289): 4.1e-14
Smith-Waterman score: 408; 32.9% identity (70.0% similar) in 210 aa overlap (13-222:28-229)
10 20 30 40
pF1KE9 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIA
.......: : ..: . :.: :: :::..
XP_011 MISAQRNHHLPDSSDSSTSAYRVARITDVIKEQNRELRGTQRAIIRDRAALEKQEKQLEL
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE9 DIKKMAKQGQMDAVRIMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKG
.:::::: :. .: ...::.::. :. . . ... ..: . ....:. .:: ::.
XP_011 EIKKMAKIGNKEACKVLAKQLVHLRKQKTRTFAVSSKVTSMSTQTKVMNSQMKMAGAMST
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE9 VTKAMGTMNRQLKLPQIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVS
..:.: ..:... . . :..:... :.: :::.::..:: . .:::::. .:.
XP_011 TAKTMQAVNKKMDPQKTLQTMQNFQKENMKMEMTEEMINDTLDDIFDGSDDEEESQDIVN
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE9 QVLDELGLSLTDELSNLPSTGGSLSVAAGGKKAEAAASALADADADLEERLKNLRRD
:::::.:. .. .... ::.. :: :. .: :. : : ..:..:: : :
XP_011 QVLDEIGIEISGKMAKAPSAARSLPSASTSK---ATIS-----DEEIERQLKALGVD
190 200 210 220
>>NP_001231573 (OMIM: 600795,609512,614696) charged mult (172 aa)
initn: 371 init1: 336 opt: 346 Z-score: 322.1 bits: 66.4 E(85289): 3.3e-11
Smith-Waterman score: 346; 33.3% identity (70.1% similar) in 177 aa overlap (46-222:4-172)
20 30 40 50 60 70
pF1KE9 RQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVRIMAKDLVRTRRYVRK
.:::::: :. .: ...::.::. :. .
NP_001 MELEIKKMAKIGNKEACKVLAKQLVHLRKQKTR
10 20 30
80 90 100 110 120 130
pF1KE9 FVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLPQIQKIMMEFERQAEI
. ... ..: . ....:. .:: ::. ..:.: ..:... . . :..:...
NP_001 TFAVSSKVTSMSTQTKVMNSQMKMAGAMSTTAKTMQAVNKKMDPQKTLQTMQNFQKENMK
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE9 MDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELSNLPSTGGSLSVAAGG
:.: :::.::..:: . .:::::. .:.:::::.:. .. .... ::.. :: :. .
NP_001 MEMTEEMINDTLDDIFDGSDDEEESQDIVNQVLDEIGIEISGKMAKAPSAARSLPSASTS
100 110 120 130 140 150
200 210 220
pF1KE9 KKAEAAASALADADADLEERLKNLRRD
: :. : : ..:..:: : :
NP_001 K---ATIS-----DEEIERQLKALGVD
160 170
>>NP_057163 (OMIM: 610052) charged multivesicular body p (222 aa)
initn: 288 init1: 288 opt: 308 Z-score: 287.4 bits: 60.4 E(85289): 2.8e-09
Smith-Waterman score: 308; 27.4% identity (63.0% similar) in 219 aa overlap (4-212:3-220)
10 20 30 40 50
pF1KE9 MDLLFGR--RKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDA
:::. .: :.::. . . . . :: .::. . .. .:.:. ..: ::.:: :.
NP_057 MGLFGKTQEKPPKELVNEWSLKIRKEMRVVDRQIRDIQREEEKVKRSVKDAAKKGQKDV
10 20 30 40 50
60 70 80 90 100 110
pF1KE9 VRIMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLK
..::...:.:. : :. .:....: . ... . .: ... :..: .:. .:
NP_057 CIVLAKEMIRSRKAVSKLYASKAHMNSVLMGMKNQLAVLRVAGSLQKSTEVMKAMQSLVK
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE9 LPQIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDE-----LGL
.:.:: : :. .. . :::..:.... .:: :::.. ....: : ::
NP_057 IPEIQATMRELSKEMMKAGIIEEMLEDTFESMDDQEEMEEEAEMEIDRILFEITAGALGK
120 130 140 150 160 170
180 190 200 210 220
pF1KE9 S---LTDELSNLPSTGGSLSVAAGGKKAEAAASALADADADLEERLKNLRRD
. .:: : . : :..... .. : : :. . : :
NP_057 APSKVTDALPE-PEPPGAMAASEDEEEEEEALEAMQSRLATLRS
180 190 200 210 220
>>NP_065145 (OMIM: 606486) charged multivesicular body p (199 aa)
initn: 342 init1: 287 opt: 296 Z-score: 277.7 bits: 58.4 E(85289): 1e-08
Smith-Waterman score: 299; 30.7% identity (66.3% similar) in 199 aa overlap (22-220:11-196)
10 20 30 40 50 60
pF1KE9 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR
:. : .::.: .: . .:: : ::: ..:.:...:
NP_065 MSNMEKHLFNLKFAAKELSRSAKKCDKEEKAEKAKIKKAIQKGNMEVAR
10 20 30 40
70 80 90 100 110 120
pF1KE9 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP
: :.. .: . . .:. : : ..::. ..:: . ......: ::.:.: . . ..:
NP_065 IHAENAIRQKNQAVNFLRMSARVDAVAARVQTAVTMGKVTKSMAGVVKSMDATLKTMNLE
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE9 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS
.:. .: .::.: : .:.. ..:.:..... ... : ..... :: ::.:. ::
NP_065 KISALMDKFEHQFETLDVQTQQMEDTMSSTTTLTTPQNQVDMLLQEMADEAGLDLNMEL-
110 120 130 140 150 160
190 200 210 220
pF1KE9 NLPSTGGSLSVAAGGKKAEAAASALADADADLEERLKNLRRD
:. : . ::.. ..::: : .: .:: ::
NP_065 --PQ-GQTGSVGT------SVASAEQD---ELSQRLARLRDQV
170 180 190
>>NP_002759 (OMIM: 164010,614961) charged multivesicular (196 aa)
initn: 215 init1: 199 opt: 258 Z-score: 244.6 bits: 52.3 E(85289): 6.9e-07
Smith-Waterman score: 260; 26.1% identity (61.8% similar) in 199 aa overlap (22-220:8-195)
10 20 30 40 50 60
pF1KE9 MDLLFGRRKTPEELLRQNQRALNRAMRELDRERQKLETQEKKIIADIKKMAKQGQMDAVR
:. . ..:.. .: : . : : .:: : ... .:
NP_002 MDDTLFQLKFTAKQLEKLAKKAEKDSKAEQAKVKKALLQKNVECAR
10 20 30 40
70 80 90 100 110 120
pF1KE9 IMAKDLVRTRRYVRKFVLMRANIQAVSLKIQTLKSNNSMAQAMKGVTKAMGTMNRQLKLP
..:.. .: . ... : . ..::. :.:: . ..... : ::::. . :
NP_002 VYAENAIRKKNEGVNWLRMASRVDAVASKVQTAVTMKGVTKNMAQVTKALDKALSTMDLQ
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE9 QIQKIMMEFERQAEIMDMKEEMMNDAIDDAMGDEEDEEESDAVVSQVLDELGLSLTDELS
.....: .::.:.. .:.. .:.:....: .:. :... :. .: :: . :.::
NP_002 KVSSVMDRFEQQVQNLDVHTSVMEDSMSSATTLTTPQEQVDSLIMQIAEENGLEVLDQLS
110 120 130 140 150 160
190 200 210 220
pF1KE9 NLPSTGGSLSVAAGGKKAEAAASALADADADLEERLKNLRRD
.:: : .: . .:. .. : .: .:: ::
NP_002 QLPE----------GASAVGESSVRSQED-QLSRRLAALRN
170 180 190
222 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 18:54:21 2016 done: Mon Nov 7 18:54:22 2016
Total Scan time: 4.410 Total Display time: -0.030
Function used was FASTA [36.3.4 Apr, 2011]