FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE9613, 314 aa
  1>>>pF1KE9613 314 - 314 aa - 314 aa
Library: human.CCDS.faa
  18511270 residues in 32554 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.3957+/-0.000713; mu= 15.4480+/- 0.043
 mean_var=64.6811+/-13.143, 0's: 0 Z-trim(109.2): 22  B-trim: 177 in 1/49
 Lambda= 0.159472
 statistics sampled from 10733 (10751) to 10733 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.714), E-opt: 0.2 (0.33), width:  16
 Scan time:  2.390

The best scores are:                                      opt bits E(32554)
CCDS9194.1 SIRT4 gene_id:23409|Hs108|chr12         ( 314) 2176 509.0  2e-144
CCDS4526.1 SIRT5 gene_id:23408|Hs108|chr6          ( 310)  396 99.4 3.7e-21
CCDS4527.1 SIRT5 gene_id:23408|Hs108|chr6          ( 299)  353 89.5 3.4e-18
CCDS56398.1 SIRT5 gene_id:23408|Hs108|chr6         ( 202)  316 80.9 8.9e-16


>>CCDS9194.1 SIRT4 gene_id:23409|Hs108|chr12              (314 aa)
 initn: 2176 init1: 2176 opt: 2176  Z-score: 2706.5  bits: 509.0 E(32554): 2e-144
Smith-Waterman score: 2176; 100.0% identity (100.0% similar) in 314 aa overlap (1-314:1-314)

               10        20        30        40        50        60
pF1KE9 MKMSFALTFRSAKGRWIANPSQPCSKASIGLFVPASPPLDPEKVKELQRFITLSKRLLVM
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS91 MKMSFALTFRSAKGRWIANPSQPCSKASIGLFVPASPPLDPEKVKELQRFITLSKRLLVM
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE9 TGAGISTESGIPDYRSEKVGLYARTDRRPIQHGDFVRSAPIRQRYWARNFVGWPQFSSHQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS91 TGAGISTESGIPDYRSEKVGLYARTDRRPIQHGDFVRSAPIRQRYWARNFVGWPQFSSHQ
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE9 PNPAHWALSTWEKLGKLYWLVTQNVDALHTKAGSRRLTELHGCMDRVLCLDCGEQTPRGV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS91 PNPAHWALSTWEKLGKLYWLVTQNVDALHTKAGSRRLTELHGCMDRVLCLDCGEQTPRGV
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE9 LQERFQVLNPTWSAEAHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLKPDVVFFGDTVNP
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS91 LQERFQVLNPTWSAEAHGLAPDGDVFLSEEQVRSFQVPTCVQCGGHLKPDVVFFGDTVNP
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE9 DKVDFVHKRVKEADSLLVVGSSLQVYSGYRFILTAWEKKLPIAILNIGPTRSDDLACLKL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS91 DKVDFVHKRVKEADSLLVVGSSLQVYSGYRFILTAWEKKLPIAILNIGPTRSDDLACLKL
              250       260       270       280       290       300

              310    
pF1KE9 NSRCGELLPLIDPC
       ::::::::::::::
CCDS91 NSRCGELLPLIDPC
              310    

>>CCDS4526.1 SIRT5 gene_id:23408|Hs108|chr6               (310 aa)
 initn: 366 init1: 166 opt: 396  Z-score: 493.3  bits: 99.4 E(32554): 3.7e-21
Smith-Waterman score: 396; 28.2% identity (55.1% similar) in 312 aa overlap (20-314:8-303)

               10        20        30                40        50  
pF1KE9 MKMSFALTFRSAKGRWIANPSQPCSKASIGLFVPASP--------PLDPEKVKELQRFIT
                          ::.  :.   ::  :::              .. ....:..
CCDS45             MRPLQIVPSRLISQLYCGLKPPASTRNQICLKMARPSSSMADFRKFFA
                           10        20        30        40        

             60        70        80        90          100         
pF1KE9 LSKRLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHGDFVRS---APIRQRYWARN
        .:......:::.:.:::.: .:.  .: :     :  :  :..     :   .: :   
CCDS45 KAKHIVIISGAGVSAESGVPTFRG--AGGYW----RKWQAQDLATPLAFAHNPSRVWEFY
       50        60        70              80        90       100  

     110       120       130           140       150       160     
pF1KE9 FVGWPQFSSHQPNPAHWALSTWE----KLGKLYWLVTQNVDALHTKAGSRRLTELHGCMD
             ..:..:: .: :..  :    : :.   ..:::.: :: :::.. : :.:: . 
CCDS45 HYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLF
            110       120       130       140       150       160  

         170       180       190       200       210       220     
pF1KE9 RVLCLDCGEQTPRGVLQERFQVLNPTWSAEAHGLAPDGDVFLSEEQVRSFQVPTCVQ--C
       .. : .::      :. : ..  .:   : .   ::.  .  .. ..   ..: : .  :
CCDS45 KTRCTSCG------VVAENYK--SPICPALSGKGAPEPGT--QDASIPVEKLPRCEEAGC
            170               180       190         200       210  

           230       240       250       260       270       280   
pF1KE9 GGHLKPDVVFFGDTVNPDKVDFVHKRVKEADSLLVVGSSLQVYSGYRFILTAWEKKLPIA
       :: :.: ::.::....:  .. : ... . :  ::::.:  :: .  :   .  . .:.:
CCDS45 GGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVA
            220       230       240       250       260       270  

           290       300       310           
pF1KE9 ILNIGPTRSDDLACLKLNSRCGELLPLIDPC       
        .:   : . .   ..... ::  ::    :       
CCDS45 EFNTETTPATNRFRFHFQGPCGTTLPEALACHENETVS
            280       290       300       310

>>CCDS4527.1 SIRT5 gene_id:23408|Hs108|chr6               (299 aa)
 initn: 326 init1: 132 opt: 353  Z-score: 440.1  bits: 89.5 E(32554): 3.4e-18
Smith-Waterman score: 370; 28.9% identity (56.0% similar) in 284 aa overlap (20-286:8-275)

               10        20        30                40        50  
pF1KE9 MKMSFALTFRSAKGRWIANPSQPCSKASIGLFVPASP--------PLDPEKVKELQRFIT
                          ::.  :.   ::  :::              .. ....:..
CCDS45             MRPLQIVPSRLISQLYCGLKPPASTRNQICLKMARPSSSMADFRKFFA
                           10        20        30        40        

             60        70        80        90          100         
pF1KE9 LSKRLLVMTGAGISTESGIPDYRSEKVGLYARTDRRPIQHGDFVRS---APIRQRYWARN
        .:......:::.:.:::.: .:.  .: : :      :  :..     :   .: :   
CCDS45 KAKHIVIISGAGVSAESGVPTFRG--AGGYWRK----WQAQDLATPLAFAHNPSRVWEFY
       50        60        70              80        90       100  

     110       120       130           140       150       160     
pF1KE9 FVGWPQFSSHQPNPAHWALSTWE----KLGKLYWLVTQNVDALHTKAGSRRLTELHGCMD
             ..:..:: .: :..  :    : :.   ..:::.: :: :::.. : :.:: . 
CCDS45 HYRREVMGSKEPNAGHRAIAECETRLGKQGRRVVVITQNIDELHRKAGTKNLLEIHGSLF
            110       120       130       140       150       160  

         170       180       190       200       210       220     
pF1KE9 RVLCLDCGEQTPRGVLQERFQVLNPTWSAEAHGLAPDGDVFLSEEQVRSFQVPTCVQ--C
       .. : .::      :. : ..  .:   : .   ::.  .  .. ..   ..: : .  :
CCDS45 KTRCTSCG------VVAENYK--SPICPALSGKGAPEPGT--QDASIPVEKLPRCEEAGC
            170               180       190         200       210  

           230       240       250       260       270       280   
pF1KE9 GGHLKPDVVFFGDTVNPDKVDFVHKRVKEADSLLVVGSSLQVYSGYRFILTAWEKKLPIA
       :: :.: ::.::....:  .. : ... . :  ::::.:  :: .  :   .  . .:.:
CCDS45 GGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVA
            220       230       240       250       260       270  

           290       300       310    
pF1KE9 ILNIGPTRSDDLACLKLNSRCGELLPLIDPC
        .:                            
CCDS45 EFNTETTPATNRFSHLISISSLIIIKN    
            280       290             

>>CCDS56398.1 SIRT5 gene_id:23408|Hs108|chr6              (202 aa)
 initn: 284 init1: 166 opt: 316  Z-score: 396.7  bits: 80.9 E(32554): 8.9e-16
Smith-Waterman score: 316; 30.0% identity (57.6% similar) in 203 aa overlap (118-314:3-195)

        90       100       110       120       130           140   
pF1KE9 RPIQHGDFVRSAPIRQRYWARNFVGWPQFSSHQPNPAHWALSTWE----KLGKLYWLVTQ
                                     :..:: .: :..  :    : :.   ..::
CCDS56                             MGSKEPNAGHRAIAECETRLGKQGRRVVVITQ
                                           10        20        30  

           150       160       170       180       190       200   
pF1KE9 NVDALHTKAGSRRLTELHGCMDRVLCLDCGEQTPRGVLQERFQVLNPTWSAEAHGLAPDG
       :.: :: :::.. : :.:: . .. : .:      ::. : ..  .:   : .   ::. 
CCDS56 NIDELHRKAGTKNLLEIHGSLFKTRCTSC------GVVAENYK--SPICPALSGKGAPEP
             40        50        60                70        80    

           210       220         230       240       250       260 
pF1KE9 DVFLSEEQVRSFQVPTCVQ--CGGHLKPDVVFFGDTVNPDKVDFVHKRVKEADSLLVVGS
        .  .. ..   ..: : .  ::: :.: ::.::....:  .. : ... . :  ::::.
CCDS56 GT--QDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEVDRELAHCDLCLVVGT
             90       100       110       120       130       140  

             270       280       290       300       310           
pF1KE9 SLQVYSGYRFILTAWEKKLPIAILNIGPTRSDDLACLKLNSRCGELLPLIDPC       
       :  :: .  :   .  . .:.: .:   : . .   ..... ::  ::    :       
CCDS56 SSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRFRFHFQGPCGTTLPEALACHENETVS
            150       160       170       180       190       200  




314 residues in 1 query   sequences
18511270 residues in 32554 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sun Nov  6 06:25:29 2016 done: Sun Nov  6 06:25:30 2016
 Total Scan time:  2.390 Total Display time:  0.010

Function used was FASTA [36.3.4 Apr, 2011]