Result of FASTA (omim) for
pFN21AE9558
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE9558, 477 aa
1>>>pF1KE9558 477 - 477 aa - 477 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4065+/-0.000336; mu= 18.0240+/- 0.021
mean_var=79.7579+/-15.948, 0's: 0 Z-trim(117.2): 225 B-trim: 626 in 2/50
Lambda= 0.143611
statistics sampled from 28738 (28968) to 28738 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.701), E-opt: 0.2 (0.34), width: 16
Scan time: 9.290
The best scores are: opt bits E(85289)
NP_000151 (OMIM: 125853,138033) glucagon receptor ( 477) 3324 698.2 1.3e-200
XP_006722340 (OMIM: 125853,138033) PREDICTED: gluc ( 477) 3324 698.2 1.3e-200
XP_016879935 (OMIM: 125853,138033) PREDICTED: gluc ( 475) 3293 691.8 1.1e-198
XP_011521841 (OMIM: 125853,138033) PREDICTED: gluc ( 444) 2634 555.3 1.3e-157
XP_016879936 (OMIM: 125853,138033) PREDICTED: gluc ( 355) 2373 501.1 2.1e-141
NP_002053 (OMIM: 138032) glucagon-like peptide 1 r ( 463) 1425 304.8 3.4e-82
XP_016866239 (OMIM: 138032) PREDICTED: glucagon-li ( 468) 1416 302.9 1.2e-81
NP_004237 (OMIM: 603659) glucagon-like peptide 2 r ( 553) 1231 264.6 4.9e-70
XP_016880828 (OMIM: 603659) PREDICTED: glucagon-li ( 559) 1209 260.1 1.2e-68
NP_000155 (OMIM: 137241) gastric inhibitory polype ( 466) 1191 256.3 1.3e-67
NP_001295347 (OMIM: 137241) gastric inhibitory pol ( 430) 1186 255.2 2.6e-67
XP_011522379 (OMIM: 603659) PREDICTED: glucagon-li ( 578) 1028 222.6 2.3e-57
XP_005256918 (OMIM: 603659) PREDICTED: glucagon-li ( 400) 993 215.2 2.6e-55
XP_016880830 (OMIM: 603659) PREDICTED: glucagon-li ( 448) 993 215.3 2.9e-55
XP_016880829 (OMIM: 603659) PREDICTED: glucagon-li ( 483) 993 215.3 3.1e-55
XP_005249618 (OMIM: 601970) PREDICTED: vasoactive ( 463) 815 178.4 3.7e-44
NP_001295188 (OMIM: 601970) vasoactive intestinal ( 422) 814 178.2 4e-44
NP_003373 (OMIM: 601970) vasoactive intestinal pol ( 438) 814 178.2 4.1e-44
XP_006716171 (OMIM: 601970) PREDICTED: vasoactive ( 392) 791 173.4 1e-42
XP_011514852 (OMIM: 601970) PREDICTED: vasoactive ( 439) 791 173.4 1.1e-42
XP_006716170 (OMIM: 601970) PREDICTED: vasoactive ( 455) 791 173.4 1.2e-42
XP_016868069 (OMIM: 601970) PREDICTED: vasoactive ( 300) 767 168.3 2.6e-41
XP_016866240 (OMIM: 138032) PREDICTED: glucagon-li ( 287) 743 163.3 8e-40
NP_002971 (OMIM: 182098) secretin receptor precurs ( 440) 718 158.3 4e-38
XP_005263787 (OMIM: 182098) PREDICTED: secretin re ( 262) 704 155.2 2e-37
XP_016860161 (OMIM: 182098) PREDICTED: secretin re ( 377) 701 154.7 4.1e-37
XP_016860159 (OMIM: 182098) PREDICTED: secretin re ( 435) 701 154.8 4.6e-37
XP_011509923 (OMIM: 182098) PREDICTED: secretin re ( 445) 701 154.8 4.7e-37
NP_001238813 (OMIM: 192321) vasoactive intestinal ( 409) 698 154.1 6.8e-37
XP_005265496 (OMIM: 192321) PREDICTED: vasoactive ( 410) 698 154.1 6.8e-37
NP_001238811 (OMIM: 192321) vasoactive intestinal ( 416) 698 154.1 6.8e-37
XP_005265495 (OMIM: 192321) PREDICTED: vasoactive ( 416) 698 154.1 6.8e-37
XP_011532381 (OMIM: 192321) PREDICTED: vasoactive ( 416) 698 154.1 6.8e-37
NP_001238814 (OMIM: 192321) vasoactive intestinal ( 430) 698 154.1 7e-37
XP_005265494 (OMIM: 192321) PREDICTED: vasoactive ( 456) 698 154.1 7.3e-37
NP_004615 (OMIM: 192321) vasoactive intestinal pol ( 457) 698 154.1 7.4e-37
XP_016860162 (OMIM: 182098) PREDICTED: secretin re ( 267) 687 151.7 2.4e-36
XP_016860160 (OMIM: 182098) PREDICTED: secretin re ( 409) 687 151.8 3.3e-36
NP_001291451 (OMIM: 601970) vasoactive intestinal ( 358) 648 143.7 8e-34
XP_005249675 (OMIM: 102981) PREDICTED: pituitary a ( 411) 645 143.1 1.4e-33
NP_001186566 (OMIM: 102981) pituitary adenylate cy ( 447) 645 143.2 1.5e-33
NP_001109 (OMIM: 102981) pituitary adenylate cycla ( 468) 645 143.2 1.5e-33
XP_016882076 (OMIM: 137241) PREDICTED: gastric inh ( 302) 626 139.1 1.7e-32
NP_001158209 (OMIM: 114131,166710) calcitonin rece ( 508) 621 138.2 5.1e-32
XP_005265401 (OMIM: 125350,156400,168468,215045,60 ( 562) 594 132.7 2.6e-30
NP_001171673 (OMIM: 125350,156400,168468,215045,60 ( 593) 594 132.7 2.8e-30
XP_016862422 (OMIM: 125350,156400,168468,215045,60 ( 593) 594 132.7 2.8e-30
NP_000307 (OMIM: 125350,156400,168468,215045,60000 ( 593) 594 132.7 2.8e-30
XP_011532270 (OMIM: 125350,156400,168468,215045,60 ( 600) 594 132.7 2.8e-30
XP_011532269 (OMIM: 125350,156400,168468,215045,60 ( 606) 594 132.7 2.8e-30
>>NP_000151 (OMIM: 125853,138033) glucagon receptor prec (477 aa)
initn: 3324 init1: 3324 opt: 3324 Z-score: 3722.9 bits: 698.2 E(85289): 1.3e-200
Smith-Waterman score: 3324; 100.0% identity (100.0% similar) in 477 aa overlap (1-477:1-477)
10 20 30 40 50 60
pF1KE9 MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 TFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 CQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 CQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 FASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 FASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYC
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 WLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 WLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 HEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 HEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRL
370 380 390 400 410 420
430 440 450 460 470
pF1KE9 GKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
430 440 450 460 470
>>XP_006722340 (OMIM: 125853,138033) PREDICTED: glucagon (477 aa)
initn: 3324 init1: 3324 opt: 3324 Z-score: 3722.9 bits: 698.2 E(85289): 1.3e-200
Smith-Waterman score: 3324; 100.0% identity (100.0% similar) in 477 aa overlap (1-477:1-477)
10 20 30 40 50 60
pF1KE9 MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 TFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 CQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 FASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYC
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 WLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 HEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRL
370 380 390 400 410 420
430 440 450 460 470
pF1KE9 GKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
430 440 450 460 470
>>XP_016879935 (OMIM: 125853,138033) PREDICTED: glucagon (475 aa)
initn: 3189 init1: 3189 opt: 3293 Z-score: 3688.2 bits: 691.8 E(85289): 1.1e-198
Smith-Waterman score: 3293; 99.6% identity (99.6% similar) in 477 aa overlap (1-477:1-475)
10 20 30 40 50 60
pF1KE9 MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNR
::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::
XP_016 MPPCQPQRPLLLLLLLLAC--QVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNR
10 20 30 40 50
70 80 90 100 110 120
pF1KE9 TFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQ
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE9 CQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANL
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE9 FASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYC
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE9 WLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDN
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE9 MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGV
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE9 HEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRL
360 370 380 390 400 410
430 440 450 460 470
pF1KE9 GKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
420 430 440 450 460 470
>>XP_011521841 (OMIM: 125853,138033) PREDICTED: glucagon (444 aa)
initn: 2634 init1: 2634 opt: 2634 Z-score: 2950.7 bits: 555.3 E(85289): 1.3e-157
Smith-Waterman score: 2634; 100.0% identity (100.0% similar) in 387 aa overlap (91-477:58-444)
70 80 90 100 110 120
pF1KE9 TFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQ
::::::::::::::::::::::::::::::
XP_011 GQSWCATEPSTSIPAGRTPPPIPRPTSPAPVQHRFVFKRCGPDGQWVRGPRGQPWRDASQ
30 40 50 60 70 80
130 140 150 160 170 180
pF1KE9 CQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANL
90 100 110 120 130 140
190 200 210 220 230 240
pF1KE9 FASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYC
150 160 170 180 190 200
250 260 270 280 290 300
pF1KE9 WLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDN
210 220 230 240 250 260
310 320 330 340 350 360
pF1KE9 MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGV
270 280 290 300 310 320
370 380 390 400 410 420
pF1KE9 HEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRL
330 340 350 360 370 380
430 440 450 460 470
pF1KE9 GKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
390 400 410 420 430 440
>>XP_016879936 (OMIM: 125853,138033) PREDICTED: glucagon (355 aa)
initn: 2373 init1: 2373 opt: 2373 Z-score: 2659.8 bits: 501.1 E(85289): 2.1e-141
Smith-Waterman score: 2373; 100.0% identity (100.0% similar) in 355 aa overlap (123-477:1-355)
100 110 120 130 140 150
pF1KE9 HRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLS
::::::::::::::::::::::::::::::
XP_016 MDGEEIEVQKEVAKMYSSFQVMYTVGYSLS
10 20 30
160 170 180 190 200 210
pF1KE9 LGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSV
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE9 STWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGW
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE9 GAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAK
160 170 180 190 200 210
340 350 360 370 380 390
pF1KE9 LRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQ
220 230 240 250 260 270
400 410 420 430 440 450
pF1KE9 GLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGR
280 290 300 310 320 330
460 470
pF1KE9 GGGSQDSSAETPLAGGLPRLAESPF
:::::::::::::::::::::::::
XP_016 GGGSQDSSAETPLAGGLPRLAESPF
340 350
>>NP_002053 (OMIM: 138032) glucagon-like peptide 1 recep (463 aa)
initn: 1373 init1: 861 opt: 1425 Z-score: 1596.7 bits: 304.8 E(85289): 3.4e-82
Smith-Waterman score: 1425; 47.5% identity (73.9% similar) in 463 aa overlap (9-461:7-456)
10 20 30 40 50
pF1KE9 MPPCQPQRPLLLLLLLLAC------QPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPP-
:: : ::::. .:: .... . . .::. : ::...:. :::
NP_002 MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETV-QKWREYRRQCQRSLTEDPPPA
10 20 30 40 50
60 70 80 90 100 110
pF1KE9 TELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQ
:.: ::::::.:.:::: .. .:.:::::::: .: . :.. : .: :.. ..
NP_002 TDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSS
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE9 -PWRDASQCQMD--GEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLH
:::: :.:. . ::. .... .: ..:::::.::..::..: ::: :. .::
NP_002 LPWRDLSECEESKRGERSSPEEQLLFLY----IIYTVGYALSFSALVIASAILLGFRHLH
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE9 CTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVF
:::: :: ::::::.:.: ::.. :. :. :: ... . . :: .::.. ..
NP_002 CTRNYIHLNLFASFILRALSVFIKDAALKWMYSTA-AQQHQWDGLLSYQDSLSCRLVFLL
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE9 MQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFE
::: ..::: ::::::.::..::....: :. .: ::..::::.:.::::::..:: :.:
NP_002 MQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYE
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE9 NVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKS
. ::: :.::..: :.:.:...:: .::.::::.. ..:.::.: : .:: : :::::
NP_002 DEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKS
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE9 TLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSE
:::::::::.:::.:::: ::::.:::: ::: .: ..:::::.::.::::.:.::: :
NP_002 TLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLE
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE9 LRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLP
.:. :.:::: .. .: :: :.. :. : .::. .:
NP_002 FRKSWERWRL-------EHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
420 430 440 450 460
pF1KE9 RLAESPF
>>XP_016866239 (OMIM: 138032) PREDICTED: glucagon-like p (468 aa)
initn: 1373 init1: 861 opt: 1416 Z-score: 1586.6 bits: 302.9 E(85289): 1.2e-81
Smith-Waterman score: 1416; 48.3% identity (73.9% similar) in 449 aa overlap (21-461:25-461)
10 20 30 40 50
pF1KE9 MPPCQPQRPLLLLLLLLACQPQVPSAQVMDF-LFE---KWKLYGDQCHHNLSLLPP
: .:: : :.: ::. : ::...:. ::
XP_016 MEIEKPSVLGGEGAGEGLAEPTGLPYMPSPQGATVSLWETVQKWREYRRQCQRSLTEDPP
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE9 P-TELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPR
: :.: ::::::.:.:::: .. .:.:::::::: .: . :.. : .: :..
XP_016 PATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDN
70 80 90 100 110 120
120 130 140 150 160
pF1KE9 GQ-PWRDASQCQMD--GEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSK
.. :::: :.:. . ::. .... .: ..:::::.::..::..: ::: :. .
XP_016 SSLPWRDLSECEESKRGERSSPEEQLLFLY----IIYTVGYALSFSALVIASAILLGFRH
130 140 150 160 170
170 180 190 200 210 220
pF1KE9 LHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAA
:::::: :: ::::::.:.: ::.. :. :. :: ... . . :: .::..
XP_016 LHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTA-AQQHQWDGLLSYQDSLSCRLVF
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE9 VFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCL
..::: ..::: ::::::.::..::....: :. .: ::..::::.:.::::::..:: :
XP_016 LLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYL
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE9 FENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLA
.:. ::: :.::..: :.:.:...:: .::.::::.. ..:.::.: : .:: : :::
XP_016 YEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLA
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE9 KSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQ
:::::::::::.:::.:::: ::::.:::: ::: .: ..:::::.::.::::.:.:::
XP_016 KSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQ
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE9 SELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGG
:.:. :.:::: .. .: :: :.. :. : .::. .:
XP_016 LEFRKSWERWRL-------EHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
420 430 440 450 460
470
pF1KE9 LPRLAESPF
>>NP_004237 (OMIM: 603659) glucagon-like peptide 2 recep (553 aa)
initn: 1126 init1: 756 opt: 1231 Z-score: 1378.4 bits: 264.6 E(85289): 4.9e-70
Smith-Waterman score: 1231; 44.9% identity (74.1% similar) in 421 aa overlap (6-422:48-458)
10 20 30
pF1KE9 MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEK
: ::.: :.::.. . :: ...... .:
NP_004 LPGVHELPMGIPAPWGTSPLSFHRKCSLWAPGRPFLTLVLLVSIK-QV-TGSLLEETTRK
20 30 40 50 60 70
40 50 60 70 80 90
pF1KE9 WKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWP-DTPANTTANISCPWYLPWHHKVQHR
: : . : ..: : :. . :: :::.: ::: ..:.:.. . :: :::: . .
NP_004 WAQYKQACLRDL--LKEPSGIFCNGTFDQYVCWPHSSPGNVS--VPCPSYLPWWSEESSG
80 90 100 110 120 130
100 110 120 130 140 150
pF1KE9 FVFKRCGPDGQWVRGPRGQP-WRDASQCQMDGEEIEVQKEVAK--MYSSFQVMYTVGYSL
....: .: : . :.: :.:. :. ...: . . :..:.:::::::.
NP_004 RAYRHCLAQGTWQTIENATDIWQDDSECS---ENHSFKQNVDRYALLSTLQLMYTVGYSF
140 150 160 170 180
160 170 180 190 200 210
pF1KE9 SLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLS
:: .:.:::..: : ::::::: :: ::::::.:.. .::: : .. . ::.. .. .
NP_004 SLISLFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYSKRPDNENG
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE9 VSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIG
..::. ... :: . :...: . ::: ::::::::::.:: ..:::: .. :: .:
NP_004 WMSYLSEMSTS-CRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLWPRYLLLG
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE9 WGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVA
:. :.::::::. .. .::. :::.: : .:::.: :..: . .:::::..:..::..
NP_004 WAFPVLFVVPWGFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLKILKLLIS
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE9 KLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSF
::.:.:: :::.:::::::.:::::::::..:.:.::....: . .::..: ::::
NP_004 KLKAHQMCFRDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFIQLTLSSF
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE9 QGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFG
.:.:::. : : : ::..:::. : :. :..
NP_004 HGFLVALQYGFANGEVKAELRKYWVRFLLARHSGCRACVLGKDFRFLGKCPKKLSEGDGA
430 440 450 460 470 480
460 470
pF1KE9 RGGGSQDSSAETPLAGGLPRLAESPF
NP_004 EKLRKLQPSLNSGRLLHLAMRGLGELGAQPQQDHARWPRGSSLSECSEGDVTMANTMEEI
490 500 510 520 530 540
>>XP_016880828 (OMIM: 603659) PREDICTED: glucagon-like p (559 aa)
initn: 1110 init1: 756 opt: 1209 Z-score: 1353.7 bits: 260.1 E(85289): 1.2e-68
Smith-Waterman score: 1209; 44.3% identity (73.1% similar) in 427 aa overlap (6-422:48-464)
10 20 30
pF1KE9 MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEK
: ::.: :.::.. . :: ...... .:
XP_016 LPGVHELPMGIPAPWGTSPLSFHRKCSLWAPGRPFLTLVLLVSIK-QV-TGSLLEETTRK
20 30 40 50 60 70
40 50 60 70 80 90
pF1KE9 WKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWP-DTPANTTANISCPWYLPWHHKVQHR
: : . : ..: : :. . :: :::.: ::: ..:.:.. . :: :::: .
XP_016 WAQYKQACLRDL--LKEPSGIFCNGTFDQYVCWPHSSPGNVS--VPCPSYLPWWSEELCL
80 90 100 110 120 130
100 110 120 130 140
pF1KE9 F------VFKRCGPDGQWVRGPRGQP-WRDASQCQMDGEEIEVQKEVAK--MYSSFQVMY
. ....: .: : . :.: :.:. :. ...: . . :..:.::
XP_016 LSESSGRAYRHCLAQGTWQTIENATDIWQDDSECS---ENHSFKQNVDRYALLSTLQLMY
140 150 160 170 180
150 160 170 180 190 200
pF1KE9 TVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQK
:::::.:: .:.:::..: : ::::::: :: ::::::.:.. .::: : .. . ::..
XP_016 TVGYSFSLISLFLALTLLLFLRKLHCTRNYIHMNLFASFILRTLAVLVKDVVFYNSYSKR
190 200 210 220 230 240
210 220 230 240 250 260
pF1KE9 IGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFS
.. . ..::. ... :: . :...: . ::: ::::::::::.:: ..:::: ..
XP_016 PDNENGWMSYLSEMSTS-CRSVQVLLHYFVGANYLWLLVEGLYLHTLLEPTVLPERRLWP
250 260 270 280 290 300
270 280 290 300 310 320
pF1KE9 LYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRI
:: .::. :.::::::. .. .::. :::.: : .:::.: :..: . .:::::..:
XP_016 RYLLLGWAFPVLFVVPWGFARAHLENTGCWTTNGNKKIWWIIRGPMMLCVTVNFFIFLKI
310 320 330 340 350 360
330 340 350 360 370 380
pF1KE9 VQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFD
..::..::.:.:: :::.:::::::.:::::::::..:.:.::....: . .::..
XP_016 LKLLISKLKAHQMCFRDYKYRLAKSTLVLIPLLGVHEILFSFITDDQVEGFAKLIRLFIQ
370 380 390 400 410 420
390 400 410 420 430 440
pF1KE9 LFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPS
: ::::.:.:::. : : : ::..:::. : :. :..
XP_016 LTLSSFHGFLVALQYGFANGEVKAELRKYWVRFLLARHSGCRACVLGKDFRFLGKCPKKL
430 440 450 460 470 480
450 460 470
pF1KE9 KELQFGRGGGSQDSSAETPLAGGLPRLAESPF
XP_016 SEGDGAEKLRKLQPSLNSGRLLHLAMRGLGELGAQPQQDHARWPRGSSLSECSEGDVTMA
490 500 510 520 530 540
>>NP_000155 (OMIM: 137241) gastric inhibitory polypeptid (466 aa)
initn: 1437 init1: 894 opt: 1191 Z-score: 1334.6 bits: 256.3 E(85289): 1.3e-67
Smith-Waterman score: 1491; 50.4% identity (73.2% similar) in 466 aa overlap (9-459:5-459)
10 20 30 40 50
pF1KE9 MPPCQPQRPLLLLLLLLA-CQPQVPSA------QVMDFLFEKWKLYGDQCHHNLSLLPPP
:.: ::: :. : . : :. :...:. : .:...:. ::
NP_000 MTTSPILQLLLRLSLCGLLLQRAETGSKGQTAGELYQRWERYRRECQETLAAAEPP
10 20 30 40 50
60 70 80 90 100 110
pF1KE9 TELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQ
. :.:: .:: : :: . :.:: ::::::::::.: ::...:: :::: :
NP_000 SGLACNGSFDMYVCWDYAAPNATARASCPWYLPWHHHVAAGFVLRQCGSDGQW-----GL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE9 PWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTR
::: .::. . :. :. . . .::::::::::::..::::: ::. . .:::::
NP_000 -WRDHTQCE-NPEKNEAFLDQRLILERLQVMYTVGYSLSLATLLLALLILSLFRRLHCTR
120 130 140 150 160
180 190 200 210 220 230
pF1KE9 NAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQY
: :: :::.::.:.:...: : :: : . .::. ... : . :.:.::.: . ::
NP_000 NYIHINLFTSFMLRAAAILSRDRLL-PRPGPYLGDQ-ALALW--NQALAACRTAQIVTQY
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE9 GIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQ
. ::: ::::::.:::.:: :. :.. : :: .::::: :::.::..:. :.::.:
NP_000 CVGANYTWLLVEGVYLHSLLVLVGGSEEGHFRYYLLLGWGAPALFVIPWVIVRYLYENTQ
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE9 CWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLT
:: :. ..:::.: :....:::::.::.::. .:..:::.:::. ::..:::.::::
NP_000 CWERNEVKAIWWIIRTPILMTILINFLIFIRILGILLSKLRTRQMRCRDYRLRLARSTLT
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE9 LIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRR
:.::::::::::: ::.:.:.:.:: ::: :..:::::::.::.:::::.:::::::.::
NP_000 LVPLLGVHEVVFAPVTEEQARGALRFAKLGFEIFLSSFQGFLVSVLYCFINKEVQSEIRR
350 360 370 380 390 400
420 430 440 450 460
pF1KE9 RWHRWRLGKVLWEERNTSNHRA------SSSPGHGPPSKELQFGR--GGGSQDSSAETPL
::. :: . : ::. .:: .:.::. : :. :. : : :.. :
NP_000 GWHHCRLRRSLGEEQRQLPERAFRALPSGSGPGEVPTSRGLSSGTLPGPGNEASRELESY
410 420 430 440 450 460
470
pF1KE9 AGGLPRLAESPF
NP_000 C
477 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 17:59:49 2016 done: Mon Nov 7 17:59:51 2016
Total Scan time: 9.290 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]