Result of FASTA (omim) for
pFN21AE9524
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE9524, 348 aa
1>>>pF1KE9524 348 - 348 aa - 348 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.6193+/-0.000481; mu= 20.3893+/- 0.030
mean_var=114.8959+/-30.449, 0's: 0 Z-trim(111.2): 526 B-trim: 1140 in 1/49
Lambda= 0.119653
statistics sampled from 19078 (19752) to 19078 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.584), E-opt: 0.2 (0.232), width: 16
Scan time: 6.760
The best scores are: opt bits E(85289)
NP_001699 (OMIM: 190900,613522) short-wave-sensiti ( 348) 2387 423.7 3e-118
NP_000530 (OMIM: 136880,180380,610445,613731) rhod ( 348) 1085 198.9 1.3e-50
NP_000504 (OMIM: 300821,303700,303800) medium-wave ( 364) 1033 190.0 6.9e-48
NP_064445 (OMIM: 300822,303700,303900) long-wave-s ( 364) 1027 189.0 1.4e-47
NP_055137 (OMIM: 606695) opsin-3 [Homo sapiens] ( 402) 533 103.7 7e-22
NP_859528 (OMIM: 609042) opsin-5 [Homo sapiens] ( 354) 402 81.0 4.2e-15
XP_016865905 (OMIM: 609042) PREDICTED: opsin-5 iso ( 408) 402 81.1 4.5e-15
NP_150598 (OMIM: 606665) melanopsin isoform 1 [Hom ( 478) 395 80.0 1.1e-14
XP_016872445 (OMIM: 606665) PREDICTED: melanopsin ( 528) 395 80.1 1.2e-14
NP_006574 (OMIM: 605224) visual pigment-like recep ( 337) 390 78.9 1.7e-14
NP_001050 (OMIM: 162332,614840) neuromedin-K recep ( 465) 390 79.2 2.1e-14
XP_016865900 (OMIM: 609042) PREDICTED: opsin-5 iso ( 298) 377 76.6 7.6e-14
NP_001049 (OMIM: 162323) substance-P receptor isof ( 407) 377 76.8 9e-14
NP_001025186 (OMIM: 606665) melanopsin isoform 2 [ ( 489) 377 76.9 1e-13
XP_016872444 (OMIM: 606665) PREDICTED: melanopsin ( 539) 377 77.0 1.1e-13
XP_016872446 (OMIM: 606665) PREDICTED: melanopsin ( 405) 373 76.1 1.5e-13
NP_056542 (OMIM: 162323) substance-P receptor isof ( 311) 368 75.1 2.3e-13
NP_001048 (OMIM: 162321) substance-K receptor [Hom ( 398) 360 73.9 6.8e-13
NP_000903 (OMIM: 165196) kappa-type opioid recepto ( 380) 335 69.5 1.3e-11
NP_001305426 (OMIM: 165196) kappa-type opioid rece ( 409) 335 69.6 1.4e-11
NP_003848 (OMIM: 603691) galanin receptor type 2 [ ( 387) 330 68.7 2.4e-11
NP_872588 (OMIM: 602548) nociceptin receptor isofo ( 370) 326 68.0 3.8e-11
NP_001186948 (OMIM: 602548) nociceptin receptor is ( 370) 326 68.0 3.8e-11
XP_016883343 (OMIM: 602548) PREDICTED: nociceptin ( 370) 326 68.0 3.8e-11
NP_000904 (OMIM: 602548) nociceptin receptor isofo ( 370) 326 68.0 3.8e-11
XP_016883342 (OMIM: 602548) PREDICTED: nociceptin ( 388) 326 68.0 3.9e-11
XP_016883341 (OMIM: 602548) PREDICTED: nociceptin ( 388) 326 68.0 3.9e-11
XP_011527130 (OMIM: 602548) PREDICTED: nociceptin ( 388) 326 68.0 3.9e-11
NP_001305782 (OMIM: 602548) nociceptin receptor is ( 399) 326 68.0 4e-11
NP_001041 (OMIM: 182452) somatostatin receptor typ ( 369) 325 67.8 4.3e-11
NP_000900 (OMIM: 162641) neuropeptide Y receptor t ( 384) 323 67.5 5.6e-11
XP_011530312 (OMIM: 162641) PREDICTED: neuropeptid ( 384) 323 67.5 5.6e-11
XP_005263088 (OMIM: 162641) PREDICTED: neuropeptid ( 384) 323 67.5 5.6e-11
XP_016865902 (OMIM: 609042) PREDICTED: opsin-5 iso ( 285) 320 66.8 6.8e-11
XP_016865901 (OMIM: 609042) PREDICTED: opsin-5 iso ( 285) 320 66.8 6.8e-11
NP_001040 (OMIM: 182451) somatostatin receptor typ ( 391) 316 66.3 1.3e-10
NP_001471 (OMIM: 600377) galanin receptor type 1 [ ( 349) 315 66.0 1.4e-10
NP_001043 (OMIM: 182454) somatostatin receptor typ ( 388) 312 65.6 2.1e-10
NP_000902 (OMIM: 165195) delta-type opioid recepto ( 372) 311 65.4 2.3e-10
NP_004239 (OMIM: 600895) prolactin-releasing pepti ( 370) 307 64.7 3.7e-10
XP_016865898 (OMIM: 609042) PREDICTED: opsin-5 iso ( 303) 302 63.7 6.1e-10
NP_001044 (OMIM: 182455) somatostatin receptor typ ( 364) 302 63.8 6.7e-10
NP_001166031 (OMIM: 182455) somatostatin receptor ( 364) 302 63.8 6.7e-10
NP_001305784 (OMIM: 602548) nociceptin receptor is ( 341) 297 62.9 1.2e-09
XP_016883344 (OMIM: 602548) PREDICTED: nociceptin ( 365) 297 62.9 1.2e-09
NP_001305783 (OMIM: 602548) nociceptin receptor is ( 365) 297 62.9 1.2e-09
XP_011527132 (OMIM: 602548) PREDICTED: nociceptin ( 289) 295 62.4 1.4e-09
NP_001138757 (OMIM: 600018) mu-type opioid recepto ( 389) 295 62.6 1.6e-09
NP_001008504 (OMIM: 600018) mu-type opioid recepto ( 392) 295 62.6 1.6e-09
NP_001138755 (OMIM: 600018) mu-type opioid recepto ( 397) 295 62.7 1.6e-09
>>NP_001699 (OMIM: 190900,613522) short-wave-sensitive o (348 aa)
initn: 2387 init1: 2387 opt: 2387 Z-score: 2244.1 bits: 423.7 E(85289): 3e-118
Smith-Waterman score: 2387; 100.0% identity (100.0% similar) in 348 aa overlap (1-348:1-348)
10 20 30 40 50 60
pF1KE9 MRKMSEEEFYLFKNISSVGPWDGPQYHIAPVWAFYLQAAFMGTVFLIGFPLNAMVLVATL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRKMSEEEFYLFKNISSVGPWDGPQYHIAPVWAFYLQAAFMGTVFLIGFPLNAMVLVATL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 RYKKLRQPLNYILVNVSFGGFLLCIFSVFPVFVASCNGYFVFGRHVCALEGFLGTVAGLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RYKKLRQPLNYILVNVSFGGFLLCIFSVFPVFVASCNGYFVFGRHVCALEGFLGTVAGLV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 TGWSLAFLAFERYIVICKPFGNFRFSSKHALTVVLATWTIGIGVSIPPFFGWSRFIPEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGWSLAFLAFERYIVICKPFGNFRFSSKHALTVVLATWTIGIGVSIPPFFGWSRFIPEGL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 QCSCGPDWYTVGTKYRSESYTWFLFIFCFIVPLSLICFSYTQLLRALKAVAAQQQESATT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QCSCGPDWYTVGTKYRSESYTWFLFIFCFIVPLSLICFSYTQLLRALKAVAAQQQESATT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 QKAEREVSRMVVVMVGSFCVCYVPYAAFAMYMVNNRNHGLDLRLVTIPSFFSKSACIYNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKAEREVSRMVVVMVGSFCVCYVPYAAFAMYMVNNRNHGLDLRLVTIPSFFSKSACIYNP
250 260 270 280 290 300
310 320 330 340
pF1KE9 IIYCFMNKQFQACIMKMVCGKAMTDESDTCSSQKTEVSTVSSTQVGPN
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IIYCFMNKQFQACIMKMVCGKAMTDESDTCSSQKTEVSTVSSTQVGPN
310 320 330 340
>>NP_000530 (OMIM: 136880,180380,610445,613731) rhodopsi (348 aa)
initn: 1064 init1: 1038 opt: 1085 Z-score: 1029.4 bits: 198.9 E(85289): 1.3e-50
Smith-Waterman score: 1085; 45.9% identity (77.5% similar) in 338 aa overlap (9-341:9-346)
10 20 30 40 50
pF1KE9 MRKMSEEEFYL-FKNISSV--GPWDGPQYHIAPVWAFYLQAAFMGTVFLIGFPLNAMVLV
::. :.: ..: .:.. :::..: : : . ::.: ....:::.: ..:
NP_000 MNGTEGPNFYVPFSNATGVVRSPFEYPQYYLAEPWQFSMLAAYMFLLIVLGFPINFLTLY
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE9 ATLRYKKLRQPLNYILVNVSFGGFLLCIFSVFPVFVASCNGYFVFGRHVCALEGFLGTVA
.:...:::: ::::::.:.. . ... . . .. .: .:::::: : ::::..:..
NP_000 VTVQHKKLRTPLNYILLNLAVADLFMVLGGFTSTLYTSLHGYFVFGPTGCNLEGFFATLG
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE9 GLVTGWSLAFLAFERYIVICKPFGNFRFSSKHALTVVLATWTIGIGVSIPPFFGWSRFIP
: .. :::. ::.:::.:.:::..::::. .::. : ::..... . ::. ::::.::
NP_000 GEIALWSLVVLAIERYVVVCKPMSNFRFGENHAIMGVAFTWVMALACAAPPLAGWSRYIP
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE9 EGLQCSCGPDWYTVGTKYRSESYTWFLFIFCFIVPLSLICFSYTQLLRALKAVAAQQQES
:::::::: :.::. . .::.. ..:. : .:. .: : : ::. ..: .:::::::
NP_000 EGLQCSCGIDYYTLKPEVNNESFVIYMFVVHFTIPMIIIFFCYGQLVFTVKEAAAQQQES
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE9 ATTQKAEREVSRMVVVMVGSFCVCYVPYAAFAMYMVNNRNHGLDLRLVTIPSFFSKSACI
:::::::.::.:::..:: .: .:.::::. :.:. .... .. ..:::.::.::: :
NP_000 ATTQKAEKEVTRMVIIMVIAFLICWVPYASVAFYIFTHQGSNFGPIFMTIPAFFAKSAAI
250 260 270 280 290 300
300 310 320 330 340
pF1KE9 YNPIIYCFMNKQFQACIMKMVC-GKA-MTDESDTCSSQKTEVSTVSSTQVGPN
:::.:: .:::::. :.. .: :: . :. . . .:::.: :.
NP_000 YNPVIYIMMNKQFRNCMLTTICCGKNPLGDDEASATVSKTETSQVAPA
310 320 330 340
>>NP_000504 (OMIM: 300821,303700,303800) medium-wave-sen (364 aa)
initn: 1052 init1: 963 opt: 1033 Z-score: 980.7 bits: 190.0 E(85289): 6.9e-48
Smith-Waterman score: 1033; 44.3% identity (74.8% similar) in 345 aa overlap (5-347:23-363)
10 20 30 40
pF1KE9 MRKMSEEEFYLFKNISSV-GPWDGPQYHIAPVWAFYLQAAFM
.. .. . : .:. ::..::.::::: :...: ...:
NP_000 MAQQWSLQRLAGRHPQDSYEDSTQSSIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSVWM
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE9 GTVFLIGFPLNAMVLVATLRYKKLRQPLNYILVNVSFGGFLLCIFSVFPVFVASCNGYFV
: . . :..::.::...::::.:::.::::.. . . ... : . ::::
NP_000 IFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISVVNQVYGYFV
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE9 FGRHVCALEGFLGTVAGLVTGWSLAFLAFERYIVICKPFGNFRFSSKHALTVVLATWTIG
.:. .:.:::. .. :.. ::::....::..:.:::::: ::..: :.. . .: .
NP_000 LGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSWIWA
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE9 IGVSIPPFFGWSRFIPEGLQCSCGPDWYTVGTKYRS-ESYTWFLFIFCFIVPLSLICFSY
. ::.:::::. :.::. ::::: .. :..: . .:: :.. : :.:::.: . :
NP_000 AVWTAPPIFGWSRYWPHGLKTSCGPDVFS-GSSYPGVQSYMIVLMVTCCITPLSIIVLCY
190 200 210 220 230
230 240 250 260 270 280
pF1KE9 TQLLRALKAVAAQQQESATTQKAEREVSRMVVVMVGSFCVCYVPYAAFAMYMVNNRNHGL
:. :..::: ::.:: .:::::.::.::::::: .:: :. ::: :: . . : .. .
NP_000 LQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMVLAFCFCWGPYAFFACFAAANPGYPF
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE9 DLRLVTIPSFFSKSACIYNPIIYCFMNKQFQACIMKMVCGKAMTDESDTCSSQKTEVSTV
....:.::.::: ::::.:: :::.::. ::... :: . : :. :..:::::.:
NP_000 HPLMAALPAFFAKSATIYNPVIYVFMNRQFRNCILQLF-GKKVDDGSELSSASKTEVSSV
300 310 320 330 340 350
pF1KE9 SSTQVGPN
:: :.:
NP_000 SS--VSPA
360
>>NP_064445 (OMIM: 300822,303700,303900) long-wave-sensi (364 aa)
initn: 1047 init1: 957 opt: 1027 Z-score: 975.1 bits: 189.0 E(85289): 1.4e-47
Smith-Waterman score: 1027; 43.2% identity (75.7% similar) in 345 aa overlap (5-347:23-363)
10 20 30 40
pF1KE9 MRKMSEEEFYLFKNISSV-GPWDGPQYHIAPVWAFYLQAAFM
.. .. . : .:. ::..::.::::: :...: ...:
NP_064 MAQQWSLQRLAGRHPQDSYEDSTQSSIFTYTNSNSTRGPFEGPNYHIAPRWVYHLTSVWM
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE9 GTVFLIGFPLNAMVLVATLRYKKLRQPLNYILVNVSFGGFLLCIFSVFPVFVASCNGYFV
: . :..::.::...::::.:::.::::.. . . ... .: . .::::
NP_064 IFVVTASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADLAETVIASTISIVNQVSGYFV
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE9 FGRHVCALEGFLGTVAGLVTGWSLAFLAFERYIVICKPFGNFRFSSKHALTVVLATWTIG
.:. .:.:::. .. :.. ::::....::..:.:::::: ::..: :.. . .: .
NP_064 LGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVVCKPFGNVRFDAKLAIVGIAFSWIWA
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE9 IGVSIPPFFGWSRFIPEGLQCSCGPDWYTVGTKYRS-ESYTWFLFIFCFIVPLSLICFSY
. ::.:::::. :.::. ::::: .. :..: . .:: :.. : :.::..: . :
NP_064 AVWTAPPIFGWSRYWPHGLKTSCGPDVFS-GSSYPGVQSYMIVLMVTCCIIPLAIIMLCY
190 200 210 220 230
230 240 250 260 270 280
pF1KE9 TQLLRALKAVAAQQQESATTQKAEREVSRMVVVMVGSFCVCYVPYAAFAMYMVNNRNHGL
:. :..::: ::.:: .:::::.::.::::::. ..:::. ::. :: . . : ....
NP_064 LQVWLAIRAVAKQQKESESTQKAEKEVTRMVVVMIFAYCVCWGPYTFFACFAAANPGYAF
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE9 DLRLVTIPSFFSKSACIYNPIIYCFMNKQFQACIMKMVCGKAMTDESDTCSSQKTEVSTV
....:..:.::: ::::.:: :::.::. ::... :: . : :. :..:::::.:
NP_064 HPLMAALPAYFAKSATIYNPVIYVFMNRQFRNCILQLF-GKKVDDGSELSSASKTEVSSV
300 310 320 330 340 350
pF1KE9 SSTQVGPN
:: :.:
NP_064 SS--VSPA
360
>>NP_055137 (OMIM: 606695) opsin-3 [Homo sapiens] (402 aa)
initn: 470 init1: 180 opt: 533 Z-score: 513.8 bits: 103.7 E(85289): 7e-22
Smith-Waterman score: 533; 30.5% identity (62.4% similar) in 311 aa overlap (19-319:23-325)
10 20 30 40 50
pF1KE9 MRKMSEEEFYLFKNISSVGPWDGPQYHIAPVWA---FYLQAAFMGTVFLIGFPLNA
:: . ::... . : ..:.. :.: :
NP_055 MYSGNRSGGHGYWDGGGAAGAEGPAPAGTLSPAPLFSPGTYERLALLLGSIGLLGVGNNL
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE9 MVLVATLRYKKLRQPLNYILVNVSFGGFLLCIFSVFPVFVASC--NGYFVFGRHVCALEG
.::: ....:: : . .:::.:.. .:. .:.: .:: :: ::. :. :. .:
NP_055 LVLVLYYKFQRLRTPTHLLLVNISLSDLLVSLFGVTFTFV-SCLRNGW-VWDTVGCVWDG
70 80 90 100 110
120 130 140 150 160 170
pF1KE9 FLGTVAGLVTGWSLAFLAFERYI-VICKPFGNFRFSSKHALTVVLATWTIGIGVSIPPFF
: :.. :.:. .:. ::.:::: :. :: .. . :.: . : ... . :..
NP_055 FSGSLFGIVSIATLTVLAYERYIRVVHARVINFSWAWR-AITYI---WLYSLAWAGAPLL
120 130 140 150 160 170
180 190 200 210 220
pF1KE9 GWSRFIPEGLQCSCGPDWYTVGTKYRSESYTWFLFIFCFIVPLSLICFSYTQLL---RAL
::.:.: . .: :: . .. . :.. :::. :..:::..: : ..: : :
NP_055 GWNRYILDVHGLGCTVDWKSKDAN--DSSFVLFLFLGCLVVPLGVIAHCYGHILYSIRML
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE9 KAVAAQQQ-ESATTQKAEREVSRMVVVMVGSFCVCYVPYAAFAMYMVNNRNHGLDLRLVT
. : : . : :.....: .:. .: ::..:: .. . .::...: . .
NP_055 RCVEDLQTIQVIKILKYEKKLAKMCFLMIFTFLVCWMPYIVICFLVVNGHGHLVTPTISI
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE9 IPSFFSKSACIYNPIIYCFMNKQFQACIMKMVCGKAMTDESDTCSSQKTEVSTVSSTQVG
. .:.:: .:::.:: :: ..:. .....:
NP_055 VSYLFAKSNTVYNPVIYVFMIRKFRRSLLQLLCLRLLRCQRPAKDLPAAGSEMQIRPIVM
300 310 320 330 340 350
pF1KE9 PN
NP_055 SQKDGDRPKKKVTFNSSSIIFIITSDESLSVDDSDKTNGSKVDVIQVRPL
360 370 380 390 400
>>NP_859528 (OMIM: 609042) opsin-5 [Homo sapiens] (354 aa)
initn: 380 init1: 229 opt: 402 Z-score: 392.1 bits: 81.0 E(85289): 4.2e-15
Smith-Waterman score: 402; 24.2% identity (59.4% similar) in 298 aa overlap (22-313:20-316)
10 20 30 40 50
pF1KE9 MRKMSEEEFYLFKNISSVGPWDGPQYHIAPVWAFYLQAAFMGTVFLIGFPL-NAMVLVAT
:: . : : :.:. :.. : . :..:: .
NP_859 MALNHTALPQDERLPHYLRDGDPFASKLSWEADLVAGFYLTIIGILSTFGNGYVLYMS
10 20 30 40 50
60 70 80 90 100 110
pF1KE9 LRYKKLRQPLNYILVNVSFGGFLLCIFSVFPVFVASCNGY-FVFGRHVCALEGFLGTVAG
: :: .: . . .:.. . . . . : . :: . .::: : :. : :
NP_859 SRRKKKLRPAEIMTINLAVCDLGISVVGK-PFTIISCFCHRWVFGWIGCRWYGWAGFFFG
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE9 LVTGWSLAFLAFERYIVICKPFGNFRFSSKHALTVVLATWTIGIGVSIPPFFGWSRFIPE
. ... ....::. :: . .. ::: . : :. . . :. : . ..::
NP_859 CGSLITMTAVSLDRYLKICYLSYGVWLKRKHAYICLAAIWAYASFWTTMPLVGLGDYVPE
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE9 GLQCSCGPDWYTVGTKYRSESYTWFLFIFCFIVPLSLICFSYTQLLRALKA----VAAQQ
. :: ::. . .. .. . ...::...: ..: :::.... .:. :: .
NP_859 PFGTSCTLDWWLAQASVGGQVFILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKEVAHFD
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE9 QESATTQKAEREVSRMVVVMVGSFCVCYVPYAAFAMYMVNNRNHGLDLRLVTIPSFFSKS
.. ... : ......... ..: . ..:::. ... . .: .. ..: ..:....::
NP_859 SRIHSSHVLEMKLTKVAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKS
240 250 260 270 280 290
300 310 320 330 340
pF1KE9 ACIYNPIIYCFMNKQFQACIMKMVCGKAMTDESDTCSSQKTEVSTVSSTQVGPN
: .:::::: .. .: :
NP_859 AAMYNPIIYQVIDYKFACCQTGGLKATKKKSLEGFRLHTVTTVRKSSAVLEIHEEWE
300 310 320 330 340 350
>>XP_016865905 (OMIM: 609042) PREDICTED: opsin-5 isoform (408 aa)
initn: 380 init1: 229 opt: 402 Z-score: 391.5 bits: 81.1 E(85289): 4.5e-15
Smith-Waterman score: 402; 24.2% identity (59.4% similar) in 298 aa overlap (22-313:20-316)
10 20 30 40 50
pF1KE9 MRKMSEEEFYLFKNISSVGPWDGPQYHIAPVWAFYLQAAFMGTVFLIGFPL-NAMVLVAT
:: . : : :.:. :.. : . :..:: .
XP_016 MALNHTALPQDERLPHYLRDGDPFASKLSWEADLVAGFYLTIIGILSTFGNGYVLYMS
10 20 30 40 50
60 70 80 90 100 110
pF1KE9 LRYKKLRQPLNYILVNVSFGGFLLCIFSVFPVFVASCNGY-FVFGRHVCALEGFLGTVAG
: :: .: . . .:.. . . . . : . :: . .::: : :. : :
XP_016 SRRKKKLRPAEIMTINLAVCDLGISVVGK-PFTIISCFCHRWVFGWIGCRWYGWAGFFFG
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE9 LVTGWSLAFLAFERYIVICKPFGNFRFSSKHALTVVLATWTIGIGVSIPPFFGWSRFIPE
. ... ....::. :: . .. ::: . : :. . . :. : . ..::
XP_016 CGSLITMTAVSLDRYLKICYLSYGVWLKRKHAYICLAAIWAYASFWTTMPLVGLGDYVPE
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE9 GLQCSCGPDWYTVGTKYRSESYTWFLFIFCFIVPLSLICFSYTQLLRALKA----VAAQQ
. :: ::. . .. .. . ...::...: ..: :::.... .:. :: .
XP_016 PFGTSCTLDWWLAQASVGGQVFILNILFFCLLLPTAVIVFSYVKIIAKVKSSSKEVAHFD
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE9 QESATTQKAEREVSRMVVVMVGSFCVCYVPYAAFAMYMVNNRNHGLDLRLVTIPSFFSKS
.. ... : ......... ..: . ..:::. ... . .: .. ..: ..:....::
XP_016 SRIHSSHVLEMKLTKVAMLICAGFLIAWIPYAVVSVWSAFGRPDSIPIQLSVVPTLLAKS
240 250 260 270 280 290
300 310 320 330 340
pF1KE9 ACIYNPIIYCFMNKQFQACIMKMVCGKAMTDESDTCSSQKTEVSTVSSTQVGPN
: .:::::: .. .: :
XP_016 AAMYNPIIYQVIDYKFACCQTGGLKATKKKSLEGFRLHTVTTVRKSSAVLEIHEEDKGRL
300 310 320 330 340 350
>>NP_150598 (OMIM: 606665) melanopsin isoform 1 [Homo sa (478 aa)
initn: 339 init1: 187 opt: 395 Z-score: 384.3 bits: 80.0 E(85289): 1.1e-14
Smith-Waterman score: 489; 28.5% identity (62.3% similar) in 305 aa overlap (30-319:66-367)
10 20 30 40 50
pF1KE9 MRKMSEEEFYLFKNISSVGPWDGPQYHIAPVWAFYLQAAFMGTVFLIGFPLNAMVLVAT
: : : .. . : : :. : :. .
NP_150 ISSLGRLPSISPTAPGTWAAAWVPLPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTF
40 50 60 70 80 90
60 70 80 90 100 110
pF1KE9 LRYKKLRQPLNYILVNVSFGGFLLCIFSVFPVF-VASCNGYFVFGRHVCALEGFLGTVAG
: ..:: : :....:.. . ::. :. ::: ..: ..::. : . .: :.. :
NP_150 CRSRSLRTPANMFIINLAVSDFLMS-FTQAPVFFTSSLYKQWLFGETGCEFYAFCGALFG
100 110 120 130 140 150
120 130 140 150 160 170
pF1KE9 LVTGWSLAFLAFERYIVICKPFGNFRFSSKH-ALTVVLATWTIGIGVSIPPFFGWSRFIP
. . .:. .:..::.:: .:...: .::. : :.:..: ... :.::::::: ..:
NP_150 ISSMITLTAIALDRYLVITRPLATFGVASKRRAAFVLLGVWLYALAWSLPPFFGWSAYVP
160 170 180 190 200 210
180 190 200 210 220 230
pF1KE9 EGLQCSCGPDWYTVGTKYRSESYTWFLFIFCFIVPLSLICFSYTQLLRALKAVAAQQQES
::: ::. :... : .:: .: : :..:: .: . : ..::.. .. :
NP_150 EGLLTSCSWDYMSFTPAVR--AYTMLLCCFVFFLPLLIIIYCYIFIFRAIRETGRALQTF
220 230 240 250 260 270
240 250 260 270 280
pF1KE9 ATTQ------------KAEREVSRMVVVMVGSFCVCYVPYAAFAMYMVNNRNHGLDLRLV
.. . ..: .......... : . ..::.: :. . : : .
NP_150 GACKGNGESLWQRQRLQSECKMAKIMLLVILLFVLSWAPYSAVALVAFAGYAHVLTPYMS
280 290 300 310 320 330
290 300 310 320 330 340
pF1KE9 TIPSFFSKSACIYNPIIYCFMNKQFQACIMKMV-CGKAMTDESDTCSSQKTEVSTVSSTQ
..:. ..:.. :.::::: . . .... : . . :
NP_150 SVPAVIAKASAIHNPIIYAITHPKYRVAIAQHLPCLGVLLGVSRRHSRPYPSYRSTHRST
340 350 360 370 380 390
pF1KE9 VGPN
NP_150 LTSHTSNLSWISIRRRQESLGSESEVGWTHMEAAAVWGAAQQANGRSLYGQGLEDLEAKA
400 410 420 430 440 450
>>XP_016872445 (OMIM: 606665) PREDICTED: melanopsin isof (528 aa)
initn: 339 init1: 187 opt: 395 Z-score: 383.9 bits: 80.1 E(85289): 1.2e-14
Smith-Waterman score: 489; 28.5% identity (62.3% similar) in 305 aa overlap (30-319:66-367)
10 20 30 40 50
pF1KE9 MRKMSEEEFYLFKNISSVGPWDGPQYHIAPVWAFYLQAAFMGTVFLIGFPLNAMVLVAT
: : : .. . : : :. : :. .
XP_016 ISSLGRLPSISPTAPGTWAAAWVPLPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTF
40 50 60 70 80 90
60 70 80 90 100 110
pF1KE9 LRYKKLRQPLNYILVNVSFGGFLLCIFSVFPVF-VASCNGYFVFGRHVCALEGFLGTVAG
: ..:: : :....:.. . ::. :. ::: ..: ..::. : . .: :.. :
XP_016 CRSRSLRTPANMFIINLAVSDFLMS-FTQAPVFFTSSLYKQWLFGETGCEFYAFCGALFG
100 110 120 130 140 150
120 130 140 150 160 170
pF1KE9 LVTGWSLAFLAFERYIVICKPFGNFRFSSKH-ALTVVLATWTIGIGVSIPPFFGWSRFIP
. . .:. .:..::.:: .:...: .::. : :.:..: ... :.::::::: ..:
XP_016 ISSMITLTAIALDRYLVITRPLATFGVASKRRAAFVLLGVWLYALAWSLPPFFGWSAYVP
160 170 180 190 200 210
180 190 200 210 220 230
pF1KE9 EGLQCSCGPDWYTVGTKYRSESYTWFLFIFCFIVPLSLICFSYTQLLRALKAVAAQQQES
::: ::. :... : .:: .: : :..:: .: . : ..::.. .. :
XP_016 EGLLTSCSWDYMSFTPAVR--AYTMLLCCFVFFLPLLIIIYCYIFIFRAIRETGRALQTF
220 230 240 250 260 270
240 250 260 270 280
pF1KE9 ATTQ------------KAEREVSRMVVVMVGSFCVCYVPYAAFAMYMVNNRNHGLDLRLV
.. . ..: .......... : . ..::.: :. . : : .
XP_016 GACKGNGESLWQRQRLQSECKMAKIMLLVILLFVLSWAPYSAVALVAFAGYAHVLTPYMS
280 290 300 310 320 330
290 300 310 320 330 340
pF1KE9 TIPSFFSKSACIYNPIIYCFMNKQFQACIMKMV-CGKAMTDESDTCSSQKTEVSTVSSTQ
..:. ..:.. :.::::: . . .... : . . :
XP_016 SVPAVIAKASAIHNPIIYAITHPKYRVAIAQHLPCLGVLLGVSRRHSRPYPSYRSTHRST
340 350 360 370 380 390
pF1KE9 VGPN
XP_016 LTSHTSNLSWISIRRRQESLGSESEVGWTHMEAAAVWGAAQQANGRSLYGQGLEDLEAKA
400 410 420 430 440 450
>>NP_006574 (OMIM: 605224) visual pigment-like receptor (337 aa)
initn: 383 init1: 332 opt: 390 Z-score: 381.1 bits: 78.9 E(85289): 1.7e-14
Smith-Waterman score: 390; 25.7% identity (59.9% similar) in 284 aa overlap (38-317:29-308)
10 20 30 40 50 60
pF1KE9 EFYLFKNISSVGPWDGPQYHIAPVWAFYLQAAFMGTVFLIGFPLNAMVLVATLRYKKLRQ
:... . .:.. : .:: ..::.::
NP_006 MLRNNLGNSSDSKNEDGSVFSQTEHNIVATYLIMAGMISIISNIIVLGIFIKYKELRT
10 20 30 40 50
70 80 90 100 110 120
pF1KE9 PLNYILVNVSFGGFLLCIFSV-FPVFVAS-CNGYFVFGRHVCALEGFLGTVAGLVTGWSL
: : :..:.. . . :. .:. .:: : . :: : . . :. :... :
NP_006 PTNAIIINLAVTD--IGVSSIGYPMSAASDLYGSWKFGYAGCQVYAGLNIFFGMASIGLL
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE9 AFLAFERYIVICKPFGNFRFSSKHALTVVLATWTIGIGVSIPPFFGWSRFIPEGLQCSCG
. .: .::..:: : . :.... . ..:..: :. .. :..::. . :. .:
NP_006 TVVAVDRYLTICLPDVGRRMTTNTYIGLILGAWINGLFWALMPIIGWASYAPDPTGATCT
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE9 PDWYTVGTKYRSESYTWFLFIFCFIVPLSLICFSYTQLLRALKA-VAAQQQESATTQKAE
.: .. ::: .. . :::::... . : .. ..: .... :: . . ..
NP_006 INWRKNDRSFV--SYTMTVIAINFIVPLTVMFYCYYHVTLSIKHHTTSDCTESLNRDWSD
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE9 R-EVSRMVVVMVGSFCVCYVPYAAFAMYMVNNRNHGLDLRLVTIPSFFSKSACIYNPIIY
. .:..: :.:. : : . ::. .. . . . .. : .:.::. .::: ::
NP_006 QIDVTKMSVIMICMFLVAWSPYSIVCLWASFGDPKKIPPPMAIIAPLFAKSSTFYNPCIY
240 250 260 270 280 290
310 320 330 340
pF1KE9 CFMNKQFQACIMKMVCGKAMTDESDTCSSQKTEVSTVSSTQVGPN
::.:. .. :
NP_006 VVANKKFRRAMLAMFKCQTHQTMPVTSILPMDVSQNPLASGRI
300 310 320 330
348 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 16:16:52 2016 done: Sun Nov 6 16:16:53 2016
Total Scan time: 6.760 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]