Result of FASTA (omim) for
pFN21AE9521
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE9521, 317 aa
1>>>pF1KE9521 317 - 317 aa - 317 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1308+/-0.000471; mu= 17.1781+/- 0.029
mean_var=119.6575+/-31.572, 0's: 0 Z-trim(110.4): 335 B-trim: 2191 in 2/48
Lambda= 0.117248
statistics sampled from 18217 (18729) to 18217 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.572), E-opt: 0.2 (0.22), width: 16
Scan time: 4.640
The best scores are: opt bits E(85289)
NP_002377 (OMIM: 155555,203200,266300,613098,61309 ( 317) 2064 360.9 2e-99
NP_005903 (OMIM: 155541,601665) melanocortin recep ( 332) 982 177.9 2.6e-44
NP_063941 (OMIM: 155540,602025,607948) melanocorti ( 323) 958 173.8 4.2e-43
NP_005904 (OMIM: 600042) melanocortin receptor 5 [ ( 325) 921 167.5 3.2e-41
NP_000520 (OMIM: 202200,607397) adrenocorticotropi ( 297) 750 138.6 1.6e-32
XP_016881270 (OMIM: 202200,607397) PREDICTED: adre ( 297) 750 138.6 1.6e-32
NP_001278840 (OMIM: 202200,607397) adrenocorticotr ( 297) 750 138.6 1.6e-32
NP_001307659 (OMIM: 601974) sphingosine 1-phosphat ( 382) 341 69.5 1.2e-11
NP_001391 (OMIM: 601974) sphingosine 1-phosphate r ( 382) 341 69.5 1.2e-11
NP_004221 (OMIM: 605111,610419,610419) sphingosine ( 353) 326 66.9 6.7e-11
XP_016882957 (OMIM: 605110) PREDICTED: lysophospha ( 351) 292 61.2 3.6e-09
NP_004711 (OMIM: 605110) lysophosphatidic acid rec ( 351) 292 61.2 3.6e-09
XP_016882958 (OMIM: 605110) PREDICTED: lysophospha ( 351) 292 61.2 3.6e-09
XP_011526723 (OMIM: 605110) PREDICTED: lysophospha ( 351) 292 61.2 3.6e-09
NP_005272 (OMIM: 600241) G-protein coupled recepto ( 330) 273 57.9 3.2e-08
NP_005217 (OMIM: 601965) sphingosine 1-phosphate r ( 378) 273 58.0 3.5e-08
NP_036284 (OMIM: 605106) lysophosphatidic acid rec ( 353) 272 57.8 3.8e-08
NP_005275 (OMIM: 600553) G-protein coupled recepto ( 362) 262 56.1 1.2e-07
NP_001273028 (OMIM: 600553) G-protein coupled rece ( 377) 262 56.2 1.3e-07
NP_005279 (OMIM: 600752) G-protein coupled recepto ( 334) 259 55.6 1.7e-07
XP_005265876 (OMIM: 104220) PREDICTED: alpha-1B ad ( 328) 253 54.5 3.4e-07
XP_006714884 (OMIM: 104220) PREDICTED: alpha-1B ad ( 331) 253 54.6 3.4e-07
XP_005265875 (OMIM: 104220) PREDICTED: alpha-1B ad ( 366) 253 54.6 3.6e-07
XP_011532740 (OMIM: 104220) PREDICTED: alpha-1B ad ( 389) 253 54.6 3.7e-07
XP_011532739 (OMIM: 104220) PREDICTED: alpha-1B ad ( 402) 253 54.7 3.8e-07
XP_016869888 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07
XP_016869892 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07
XP_016869885 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07
XP_016869877 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07
XP_016869894 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07
XP_005251838 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07
XP_016869893 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07
XP_016869887 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07
XP_016869878 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07
XP_016869883 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07
XP_016869872 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07
XP_016869876 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07
XP_016869889 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07
NP_001392 (OMIM: 602282) lysophosphatidic acid rec ( 364) 252 54.4 4e-07
XP_016869879 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07
XP_016869886 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07
XP_016869880 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07
XP_005251839 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07
XP_016869884 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07
XP_016869895 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07
XP_016869874 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07
XP_016869896 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07
XP_016869891 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07
NP_476500 (OMIM: 602282) lysophosphatidic acid rec ( 364) 252 54.4 4e-07
XP_016869875 (OMIM: 602282) PREDICTED: lysophospha ( 364) 252 54.4 4e-07
>>NP_002377 (OMIM: 155555,203200,266300,613098,613099) m (317 aa)
initn: 2064 init1: 2064 opt: 2064 Z-score: 1906.0 bits: 360.9 E(85289): 2e-99
Smith-Waterman score: 2064; 100.0% identity (100.0% similar) in 317 aa overlap (1-317:1-317)
10 20 30 40 50 60
pF1KE9 MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 ATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 DVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 AYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 AYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 VTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 VTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAF
250 260 270 280 290 300
310
pF1KE9 HSQELRRTLKEVLTCSW
:::::::::::::::::
NP_002 HSQELRRTLKEVLTCSW
310
>>NP_005903 (OMIM: 155541,601665) melanocortin receptor (332 aa)
initn: 982 init1: 398 opt: 982 Z-score: 916.6 bits: 177.9 E(85289): 2.6e-44
Smith-Waterman score: 982; 51.2% identity (78.1% similar) in 297 aa overlap (20-315:27-319)
10 20 30 40 50
pF1KE9 MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLE-VSISDGLFLSLGLVS
: .:: . .. : : : . .: .:..::..:
NP_005 MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGG--CYEQLFVSPEVFVTLGVIS
10 20 30 40 50
60 70 80 90 100 110
pF1KE9 LVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAV
:.:: ::...::::.::::::: ::: ::..:.::: :: :: :: ::.. :.. .
NP_005 LLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFT
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE9 LQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVAS
.. .::::: . :::.:.:.: : .::::::..:::::.::.:.:. :. .. ::.:
NP_005 VN-IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAAC
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE9 VVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVH
.: . ::: : : ::..::...:..::.::: :::::. : : . :: : ..
NP_005 TVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTG-AIR
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE9 QGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAI
:: ..:::.:::::.:.: .::.:::::: . . ::..: : :....:::.: ::.::.:
NP_005 QGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSI
240 250 260 270 280 290
300 310
pF1KE9 IDPLIYAFHSQELRRTLKEVLTCSW
:::::::..:::::.:.::.. :
NP_005 IDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
300 310 320 330
>>NP_063941 (OMIM: 155540,602025,607948) melanocortin re (323 aa)
initn: 940 init1: 584 opt: 958 Z-score: 894.8 bits: 173.8 E(85289): 4.2e-43
Smith-Waterman score: 958; 49.5% identity (77.6% similar) in 295 aa overlap (23-315:22-315)
10 20 30 40 50
pF1KE9 MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTG-ARCLEVSISDGLFLSLGLVSLVENALV
: . .::.. : : .: :. .:::::.:::.:: ::
NP_063 MNASCCLPSVQPTLPNGSEHLQAPFFSNQSSSAFCEQVFIKPEVFLSLGIVSLLENILV
10 20 30 40 50
60 70 80 90 100 110
pF1KE9 VATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNV
. ....: ::::::: :.: ::..:.::: ::.::: .: .... :. . .:..::.
NP_063 ILAVVRNGNLHSPMYFFLCSLAVADMLVSVSNALETIMIAIVHSDYLTFEDQFIQHMDNI
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE9 IDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLF
.: . : :...:.: : :::::::..::::::::::.:. .: ..:::: : ...:
NP_063 FDSMICISLVASICNLLAIAVDRYVTIFYALRYHSIMTVRKALTLIVAIWVCCGVCGVVF
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE9 IAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFG-LK
:.: . :..::...:.::..::..:::::. : :.. :: : . . : . .:
NP_063 IVYSESKMVIVCLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMK
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE9 GAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIY
::::.:::::.:..::.::::::.::. :: .: : : .:: .:.::.::..::::::
NP_063 GAVTITILLGVFIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIY
240 250 260 270 280 290
300 310
pF1KE9 AFHSQELRRTLKEVLTCSW
::.: ::: :..:.: :
NP_063 AFRSLELRNTFREIL-CGCNGMNLG
300 310 320
>>NP_005904 (OMIM: 600042) melanocortin receptor 5 [Homo (325 aa)
initn: 904 init1: 563 opt: 921 Z-score: 860.9 bits: 167.5 E(85289): 3.2e-41
Smith-Waterman score: 921; 45.9% identity (76.9% similar) in 303 aa overlap (13-315:13-312)
10 20 30 40 50 60
pF1KE9 MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVV
.::.: . : ... .. : ...:. .::.::..::.:: ::.
NP_005 MNSSFHLHFLDLNLNATEGNLS--GPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVI
10 20 30 40 50
70 80 90 100 110 120
pF1KE9 ATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVI
..:.::.::::::: :.: ::..:.::: :.. :: .: ::. :: : ....:::.
NP_005 GAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVF
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE9 DVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFI
: . : :...:.: : :::::::..:::::::: :.: :. .:.::. . . .::
NP_005 DSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFI
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE9 AYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGA
: . . :.:::. .:.::: :.. ::.::. : :.. :: : . ..: ...::
NP_005 LYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASS-ARQRTSMQGA
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE9 VTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAF
::.:.:::.: .::.::::::::.. ::.. :. ....::..: ::.::...:::::::
NP_005 VTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAF
240 250 260 270 280 290
310
pF1KE9 HSQELRRTLKEVLTCSW
.:::.:.:.::.. :
NP_005 RSQEMRKTFKEIICCRGFRIACSFPRRD
300 310 320
>>NP_000520 (OMIM: 202200,607397) adrenocorticotropic ho (297 aa)
initn: 773 init1: 390 opt: 750 Z-score: 705.0 bits: 138.6 E(85289): 1.6e-32
Smith-Waterman score: 750; 40.7% identity (73.0% similar) in 285 aa overlap (35-317:21-297)
10 20 30 40 50 60
pF1KE9 GSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIA
: .: . . .:.....:...:: .:. ..
NP_000 MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVF
10 20 30 40 50
70 80 90 100 110 120
pF1KE9 KNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDVIT
::.::..::: ::: ::.::.: : ..::. .:.: . : : :.. :..:: .
NP_000 KNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLF
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE9 CSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYD
:.:.:. :..::.::::.::.:::::::::. :. ....::. . . .. .
NP_000 VLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSH
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE9 HVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLT
:: ... .. .: :::.. :::::. : .:.. :. : . . .:::.:::
NP_000 HVPTVITFTSLFPLMLVFILCLYVHMFLLARSHTRKISTLPRAN--------MKGAITLT
180 190 200 210 220
250 260 270 280 290 300
pF1KE9 ILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQE
::::.:..::.:: ::. :...:: .: :.: .. :.. ::.:::.:::.::::.: :
NP_000 ILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPE
230 240 250 260 270 280
310
pF1KE9 LRRTLKEVLTCS--W
:: ..:... :: :
NP_000 LRDAFKKMIFCSRYW
290
>>XP_016881270 (OMIM: 202200,607397) PREDICTED: adrenoco (297 aa)
initn: 773 init1: 390 opt: 750 Z-score: 705.0 bits: 138.6 E(85289): 1.6e-32
Smith-Waterman score: 750; 40.7% identity (73.0% similar) in 285 aa overlap (35-317:21-297)
10 20 30 40 50 60
pF1KE9 GSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIA
: .: . . .:.....:...:: .:. ..
XP_016 MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVF
10 20 30 40 50
70 80 90 100 110 120
pF1KE9 KNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDVIT
::.::..::: ::: ::.::.: : ..::. .:.: . : : :.. :..:: .
XP_016 KNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLF
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE9 CSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYD
:.:.:. :..::.::::.::.:::::::::. :. ....::. . . .. .
XP_016 VLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSH
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE9 HVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLT
:: ... .. .: :::.. :::::. : .:.. :. : . . .:::.:::
XP_016 HVPTVITFTSLFPLMLVFILCLYVHMFLLARSHTRKISTLPRAN--------MKGAITLT
180 190 200 210 220
250 260 270 280 290 300
pF1KE9 ILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQE
::::.:..::.:: ::. :...:: .: :.: .. :.. ::.:::.:::.::::.: :
XP_016 ILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPE
230 240 250 260 270 280
310
pF1KE9 LRRTLKEVLTCS--W
:: ..:... :: :
XP_016 LRDAFKKMIFCSRYW
290
>>NP_001278840 (OMIM: 202200,607397) adrenocorticotropic (297 aa)
initn: 773 init1: 390 opt: 750 Z-score: 705.0 bits: 138.6 E(85289): 1.6e-32
Smith-Waterman score: 750; 40.7% identity (73.0% similar) in 285 aa overlap (35-317:21-297)
10 20 30 40 50 60
pF1KE9 GSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIA
: .: . . .:.....:...:: .:. ..
NP_001 MKHIINSYENINNTARNNSDCPRVVLPEEIFFTISIVGVLENLIVLLAVF
10 20 30 40 50
70 80 90 100 110 120
pF1KE9 KNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDVIT
::.::..::: ::: ::.::.: : ..::. .:.: . : : :.. :..:: .
NP_001 KNKNLQAPMYFFICSLAISDMLGSLYKILENILIILRNMGYLKPRGSFETTADDIIDSLF
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE9 CSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYD
:.:.:. :..::.::::.::.:::::::::. :. ....::. . . .. .
NP_001 VLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVVLTVIWTFCTGTGITMVIFSH
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE9 HVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLT
:: ... .. .: :::.. :::::. : .:.. :. : . . .:::.:::
NP_001 HVPTVITFTSLFPLMLVFILCLYVHMFLLARSHTRKISTLPRAN--------MKGAITLT
180 190 200 210 220
250 260 270 280 290 300
pF1KE9 ILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQE
::::.:..::.:: ::. :...:: .: :.: .. :.. ::.:::.:::.::::.: :
NP_001 ILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMSLFQVNGMLIMCNAVIDPFIYAFRSPE
230 240 250 260 270 280
310
pF1KE9 LRRTLKEVLTCS--W
:: ..:... :: :
NP_001 LRDAFKKMIFCSRYW
290
>>NP_001307659 (OMIM: 601974) sphingosine 1-phosphate re (382 aa)
initn: 277 init1: 114 opt: 341 Z-score: 330.0 bits: 69.5 E(85289): 1.2e-11
Smith-Waterman score: 359; 28.3% identity (61.9% similar) in 315 aa overlap (23-315:34-328)
10 20 30 40 50
pF1KE9 MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVS
.:...:.. .. ..... .:. .
NP_001 TSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENS----IKLTSVVFILICCFI
10 20 30 40 50
60 70 80 90 100 110
pF1KE9 LVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAV
..:: .:. :: :....: ::: :: ::::::: ..: :: .:: .:: . . .
NP_001 ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLL---AGVAYTANLLL--SGATTYKLTP
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE9 LQQL--DNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWV
: . .. . : .:..: : :::..:::... .. :. . : ..: ::
NP_001 AQWFLREGSMFVALSASVFSLL----AIAIERYITML-KMKLHNGSNNFRLFLLISACWV
120 130 140 150 160
180 190 200 210
pF1KE9 ASVVF-----------------STLFIAYYDHVAVLLCLVVFFLAMLVLMAVLY--VHML
:... ::.. :. : .:.: .:: : .:. ...:: .. :
NP_001 ISLILGGLPIMGWNCISALSSCSTVLPLYHKHY-ILFCTTVFTL-LLLSIVILYCRIYSL
170 180 190 200 210 220
220 230 240 250 260 270
pF1KE9 ARACQHAQGIAR-LHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEH
.:. .. . . . : .: .....: :. :.:..:. ::.:.:. : : : : .
NP_001 VRTRSRRLTFRKNISKASRSSEKSLALLK--TVIIVLSVFIACWAPLFILLLLDVGC-KV
230 240 250 260 270 280
280 290 300 310
pF1KE9 PTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCSW
:: .:. . ::.: . :. .:.::.. ..:.::.. ....:
NP_001 KTCDILFRA-EYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRP
290 300 310 320 330 340
NP_001 IIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
350 360 370 380
>>NP_001391 (OMIM: 601974) sphingosine 1-phosphate recep (382 aa)
initn: 277 init1: 114 opt: 341 Z-score: 330.0 bits: 69.5 E(85289): 1.2e-11
Smith-Waterman score: 359; 28.3% identity (61.9% similar) in 315 aa overlap (23-315:34-328)
10 20 30 40 50
pF1KE9 MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVS
.:...:.. .. ..... .:. .
NP_001 TSVPLVKAHRSSVSDYVNYDIIVRHYNYTGKLNISADKENS----IKLTSVVFILICCFI
10 20 30 40 50
60 70 80 90 100 110
pF1KE9 LVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAV
..:: .:. :: :....: ::: :: ::::::: ..: :: .:: .:: . . .
NP_001 ILENIFVLLTIWKTKKFHRPMYYFIGNLALSDLL---AGVAYTANLLL--SGATTYKLTP
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE9 LQQL--DNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWV
: . .. . : .:..: : :::..:::... .. :. . : ..: ::
NP_001 AQWFLREGSMFVALSASVFSLL----AIAIERYITML-KMKLHNGSNNFRLFLLISACWV
120 130 140 150 160
180 190 200 210
pF1KE9 ASVVF-----------------STLFIAYYDHVAVLLCLVVFFLAMLVLMAVLY--VHML
:... ::.. :. : .:.: .:: : .:. ...:: .. :
NP_001 ISLILGGLPIMGWNCISALSSCSTVLPLYHKHY-ILFCTTVFTL-LLLSIVILYCRIYSL
170 180 190 200 210 220
220 230 240 250 260 270
pF1KE9 ARACQHAQGIAR-LHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEH
.:. .. . . . : .: .....: :. :.:..:. ::.:.:. : : : : .
NP_001 VRTRSRRLTFRKNISKASRSSEKSLALLK--TVIIVLSVFIACWAPLFILLLLDVGC-KV
230 240 250 260 270 280
280 290 300 310
pF1KE9 PTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCSW
:: .:. . ::.: . :. .:.::.. ..:.::.. ....:
NP_001 KTCDILFRA-EYFLVLAVLNSGTNPIIYTLTNKEMRRAFIRIMSCCKCPSGDSAGKFKRP
290 300 310 320 330 340
NP_001 IIAGMEFSRSKSDNSSHPQKDEGDNPETIMSSGNVNSSS
350 360 370 380
>>NP_004221 (OMIM: 605111,610419,610419) sphingosine 1-p (353 aa)
initn: 339 init1: 109 opt: 326 Z-score: 316.6 bits: 66.9 E(85289): 6.7e-11
Smith-Waterman score: 326; 29.6% identity (59.9% similar) in 294 aa overlap (40-317:35-306)
10 20 30 40 50 60
pF1KE9 LLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIAKNRNL
....... : . .::: ::. ..:.: ..
NP_004 YSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 HSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDV-ITCSSM
:: :: :. :: ::::.. . : .: : .:... : . .: . .. :: :.
NP_004 HSAMYLFLGNLAASDLLAGVAFVANT-----LLSGSVTLRLTPVQWFAREGSAFITLSAS
70 80 90 100 110
130 140 150 160 170 180
pF1KE9 LSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYD---H
. :: :::..:...: . : : . : ..: :. :.:.. : : .. :
NP_004 VFSLL---AIAIERHVAIAKVKLYGSDKSC-RMLLLIGASWLISLVLGGLPILGWNCLGH
120 130 140 150 160 170
190 200 210 220 230
pF1KE9 VAV------------LLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQ
. . .::.:..: .:. ...:::.. : ..: . . . :
NP_004 LEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIY---C-----VVRSSHADMAAPQ
180 190 200 210 220
240 250 260 270 280 290
pF1KE9 GFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAII
..: :.::.::.:..:: : : : : :: : .: ..: . :.:. :...
NP_004 TLALLK--TVTIVLGVFIVCWLPAFSILLLDYACPVH-SCPILYKA-HYFFAVSTLNSLL
230 240 250 260 270 280
300 310
pF1KE9 DPLIYAFHSQELRRTLKEVLTCSW
.:.::...:..::: . . : : :
NP_004 NPVIYTWRSRDLRREVLRPLQC-WRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPT
290 300 310 320 330 340
317 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 02:17:50 2016 done: Tue Nov 8 02:17:51 2016
Total Scan time: 4.640 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]