Result of FASTA (omim) for
pFN21AE9501
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE9501, 487 aa
1>>>pF1KE9501 487 - 487 aa - 487 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.2674+/-0.000452; mu= 13.9692+/- 0.029
mean_var=124.9537+/-28.171, 0's: 0 Z-trim(113.1): 521 B-trim: 2161 in 2/49
Lambda= 0.114736
statistics sampled from 21588 (22262) to 21588 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.614), E-opt: 0.2 (0.261), width: 16
Scan time: 8.260
The best scores are: opt bits E(85289)
NP_001091681 (OMIM: 600167) histamine H1 receptor ( 487) 3291 556.7 5.5e-158
NP_000852 (OMIM: 600167) histamine H1 receptor [Ho ( 487) 3291 556.7 5.5e-158
XP_011531954 (OMIM: 600167) PREDICTED: histamine H ( 487) 3291 556.7 5.5e-158
NP_001091683 (OMIM: 600167) histamine H1 receptor ( 487) 3291 556.7 5.5e-158
XP_011531955 (OMIM: 600167) PREDICTED: histamine H ( 487) 3291 556.7 5.5e-158
XP_016861773 (OMIM: 600167) PREDICTED: histamine H ( 487) 3291 556.7 5.5e-158
NP_001091682 (OMIM: 600167) histamine H1 receptor ( 487) 3291 556.7 5.5e-158
XP_016861772 (OMIM: 600167) PREDICTED: histamine H ( 487) 3291 556.7 5.5e-158
NP_001307846 (OMIM: 118496) muscarinic acetylcholi ( 532) 464 88.7 4.3e-17
NP_036257 (OMIM: 118496) muscarinic acetylcholine ( 532) 464 88.7 4.3e-17
XP_011542345 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16
XP_016855644 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16
XP_016855645 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16
XP_016855651 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16
XP_016855649 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16
XP_011542349 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16
XP_016855643 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16
XP_016855646 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16
XP_016855647 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16
NP_000731 (OMIM: 100100,118494) muscarinic acetylc ( 590) 454 87.1 1.5e-16
XP_016855642 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16
XP_011542346 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16
XP_011542343 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16
XP_011542347 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16
XP_011542348 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16
XP_016855648 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16
XP_005273089 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16
XP_016855652 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16
XP_016855641 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16
XP_016855650 (OMIM: 100100,118494) PREDICTED: musc ( 590) 454 87.1 1.5e-16
NP_001006631 (OMIM: 118493) muscarinic acetylcholi ( 466) 452 86.7 1.5e-16
NP_001006627 (OMIM: 118493) muscarinic acetylcholi ( 466) 452 86.7 1.5e-16
NP_001006629 (OMIM: 118493) muscarinic acetylcholi ( 466) 452 86.7 1.5e-16
NP_001006632 (OMIM: 118493) muscarinic acetylcholi ( 466) 452 86.7 1.5e-16
NP_000730 (OMIM: 118493) muscarinic acetylcholine ( 466) 452 86.7 1.5e-16
NP_001006633 (OMIM: 118493) muscarinic acetylcholi ( 466) 452 86.7 1.5e-16
XP_011514071 (OMIM: 118493) PREDICTED: muscarinic ( 466) 452 86.7 1.5e-16
NP_001006628 (OMIM: 118493) muscarinic acetylcholi ( 466) 452 86.7 1.5e-16
NP_001006630 (OMIM: 118493) muscarinic acetylcholi ( 466) 452 86.7 1.5e-16
NP_000732 (OMIM: 118495) muscarinic acetylcholine ( 479) 450 86.4 2e-16
NP_000729 (OMIM: 118510) muscarinic acetylcholine ( 460) 443 85.2 4.3e-16
XP_011543044 (OMIM: 118510) PREDICTED: muscarinic ( 460) 443 85.2 4.3e-16
NP_000856 (OMIM: 182132) 5-hydroxytryptamine recep ( 365) 428 82.6 2e-15
XP_011534091 (OMIM: 182132) PREDICTED: 5-hydroxytr ( 365) 428 82.6 2e-15
NP_000854 (OMIM: 182131) 5-hydroxytryptamine recep ( 390) 427 82.5 2.4e-15
NP_000015 (OMIM: 109690,600807,601665) beta-2 adre ( 413) 412 80.0 1.4e-14
NP_071640 (OMIM: 142703) histamine H2 receptor iso ( 359) 405 78.8 2.8e-14
XP_006714928 (OMIM: 142703) PREDICTED: histamine H ( 362) 405 78.8 2.8e-14
NP_001124527 (OMIM: 142703) histamine H2 receptor ( 397) 405 78.9 3e-14
XP_016864915 (OMIM: 142703) PREDICTED: histamine H ( 422) 405 78.9 3.2e-14
>>NP_001091681 (OMIM: 600167) histamine H1 receptor [Hom (487 aa)
initn: 3291 init1: 3291 opt: 3291 Z-score: 2957.4 bits: 556.7 E(85289): 5.5e-158
Smith-Waterman score: 3291; 100.0% identity (100.0% similar) in 487 aa overlap (1-487:1-487)
10 20 30 40 50 60
pF1KE9 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
430 440 450 460 470 480
pF1KE9 RILHIRS
:::::::
NP_001 RILHIRS
>>NP_000852 (OMIM: 600167) histamine H1 receptor [Homo s (487 aa)
initn: 3291 init1: 3291 opt: 3291 Z-score: 2957.4 bits: 556.7 E(85289): 5.5e-158
Smith-Waterman score: 3291; 100.0% identity (100.0% similar) in 487 aa overlap (1-487:1-487)
10 20 30 40 50 60
pF1KE9 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
430 440 450 460 470 480
pF1KE9 RILHIRS
:::::::
NP_000 RILHIRS
>>XP_011531954 (OMIM: 600167) PREDICTED: histamine H1 re (487 aa)
initn: 3291 init1: 3291 opt: 3291 Z-score: 2957.4 bits: 556.7 E(85289): 5.5e-158
Smith-Waterman score: 3291; 100.0% identity (100.0% similar) in 487 aa overlap (1-487:1-487)
10 20 30 40 50 60
pF1KE9 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
430 440 450 460 470 480
pF1KE9 RILHIRS
:::::::
XP_011 RILHIRS
>>NP_001091683 (OMIM: 600167) histamine H1 receptor [Hom (487 aa)
initn: 3291 init1: 3291 opt: 3291 Z-score: 2957.4 bits: 556.7 E(85289): 5.5e-158
Smith-Waterman score: 3291; 100.0% identity (100.0% similar) in 487 aa overlap (1-487:1-487)
10 20 30 40 50 60
pF1KE9 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
430 440 450 460 470 480
pF1KE9 RILHIRS
:::::::
NP_001 RILHIRS
>>XP_011531955 (OMIM: 600167) PREDICTED: histamine H1 re (487 aa)
initn: 3291 init1: 3291 opt: 3291 Z-score: 2957.4 bits: 556.7 E(85289): 5.5e-158
Smith-Waterman score: 3291; 100.0% identity (100.0% similar) in 487 aa overlap (1-487:1-487)
10 20 30 40 50 60
pF1KE9 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
430 440 450 460 470 480
pF1KE9 RILHIRS
:::::::
XP_011 RILHIRS
>>XP_016861773 (OMIM: 600167) PREDICTED: histamine H1 re (487 aa)
initn: 3291 init1: 3291 opt: 3291 Z-score: 2957.4 bits: 556.7 E(85289): 5.5e-158
Smith-Waterman score: 3291; 100.0% identity (100.0% similar) in 487 aa overlap (1-487:1-487)
10 20 30 40 50 60
pF1KE9 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
430 440 450 460 470 480
pF1KE9 RILHIRS
:::::::
XP_016 RILHIRS
>>NP_001091682 (OMIM: 600167) histamine H1 receptor [Hom (487 aa)
initn: 3291 init1: 3291 opt: 3291 Z-score: 2957.4 bits: 556.7 E(85289): 5.5e-158
Smith-Waterman score: 3291; 100.0% identity (100.0% similar) in 487 aa overlap (1-487:1-487)
10 20 30 40 50 60
pF1KE9 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
430 440 450 460 470 480
pF1KE9 RILHIRS
:::::::
NP_001 RILHIRS
>>XP_016861772 (OMIM: 600167) PREDICTED: histamine H1 re (487 aa)
initn: 3291 init1: 3291 opt: 3291 Z-score: 2957.4 bits: 556.7 E(85289): 5.5e-158
Smith-Waterman score: 3291; 100.0% identity (100.0% similar) in 487 aa overlap (1-487:1-487)
10 20 30 40 50 60
pF1KE9 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE9 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE9 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE9 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
430 440 450 460 470 480
pF1KE9 RILHIRS
:::::::
XP_016 RILHIRS
>>NP_001307846 (OMIM: 118496) muscarinic acetylcholine r (532 aa)
initn: 701 init1: 398 opt: 464 Z-score: 427.9 bits: 88.7 E(85289): 4.3e-17
Smith-Waterman score: 688; 29.0% identity (58.8% similar) in 486 aa overlap (26-486:29-513)
10 20 30 40 50
pF1KE9 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERK
... ...: ... :.:. :.::. . . . .
NP_001 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQ
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE9 LHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFS
:.::.: :..::. ::::.: : . :.::..:.:: : .::..:::::.::...
NP_001 LKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMN
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE9 VFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRR
.... .::: :. .:: : :: ::. : ::..:: ::. :: :.... . .:
NP_001 LLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPL
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE9 EDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSE
:.:. .: . . ::: ::.:. .: .: .::. .... . .. : .
NP_001 -DECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKA
190 200 210 220 230
240 250 260 270 280
pF1KE9 IKLRPEN----------PKGD-AKKPGKESPWEVLKRKPKDAGGGSVLKSPSQT-PKEMK
: .: . :. :.. ... : .:. . .: : .:: . : .
NP_001 EKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQ
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE9 SPVVFSQEDDREVDKLYCFP-LDIVHMQAAAEGSSRDYVA--VNRSHGQLKTDEQGLNTH
. : .... :: : :..:. . . :. .... : .... . .:... .:
NP_001 LTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTP
300 310 320 330 340 350
350 360 370 380 390
pF1KE9 G------ASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLR
. :.. ..: . . .: . :: : :.. . . : :
NP_001 NYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLN
360 370 380 390 400 410
400 410 420 430 440 450
pF1KE9 ---SHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMF
::. . . . .:::::. :. :. :::. : :: :. .: .:: .: : .
NP_001 PNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHL
420 430 440 450 460 470
460 470 480
pF1KE9 TIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
:: :.:::.::. : :::..:.:::: .: :
NP_001 GYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
480 490 500 510 520 530
>>NP_036257 (OMIM: 118496) muscarinic acetylcholine rece (532 aa)
initn: 701 init1: 398 opt: 464 Z-score: 427.9 bits: 88.7 E(85289): 4.3e-17
Smith-Waterman score: 688; 29.0% identity (58.8% similar) in 486 aa overlap (26-486:29-513)
10 20 30 40 50
pF1KE9 MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERK
... ...: ... :.:. :.::. . . . .
NP_036 MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQ
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE9 LHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFS
:.::.: :..::. ::::.: : . :.::..:.:: : .::..:::::.::...
NP_036 LKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMN
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE9 VFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSF-LWVIPILGWNHFMQQTSVRR
.... .::: :. .:: : :: ::. : ::..:: ::. :: :.... . .:
NP_036 LLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPL
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE9 EDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSE
:.:. .: . . ::: ::.:. .: .: .::. .... . .. : .
NP_036 -DECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKA
190 200 210 220 230
240 250 260 270 280
pF1KE9 IKLRPEN----------PKGD-AKKPGKESPWEVLKRKPKDAGGGSVLKSPSQT-PKEMK
: .: . :. :.. ... : .:. . .: : .:: . : .
NP_036 EKRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQ
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE9 SPVVFSQEDDREVDKLYCFP-LDIVHMQAAAEGSSRDYVA--VNRSHGQLKTDEQGLNTH
. : .... :: : :..:. . . :. .... : .... . .:... .:
NP_036 LTTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTP
300 310 320 330 340 350
350 360 370 380 390
pF1KE9 G------ASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLR
. :.. ..: . . .: . :: : :.. . . : :
NP_036 NYLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLN
360 370 380 390 400 410
400 410 420 430 440 450
pF1KE9 ---SHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMF
::. . . . .:::::. :. :. :::. : :: :. .: .:: .: : .
NP_036 PNPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHL
420 430 440 450 460 470
460 470 480
pF1KE9 TIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
:: :.:::.::. : :::..:.:::: .: :
NP_036 GYWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP
480 490 500 510 520 530
487 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 03:49:19 2016 done: Mon Nov 7 03:49:20 2016
Total Scan time: 8.260 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]