Result of FASTA (omim) for
pFN21AE9420
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE9420, 337 aa
1>>>pF1KE9420 337 - 337 aa - 337 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.5663+/-0.000445; mu= 20.5567+/- 0.027
mean_var=130.1236+/-33.674, 0's: 0 Z-trim(110.5): 626 B-trim: 1168 in 1/52
Lambda= 0.112434
statistics sampled from 18049 (18860) to 18049 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.556), E-opt: 0.2 (0.221), width: 16
Scan time: 7.100
The best scores are: opt bits E(85289)
NP_003958 (OMIM: 607405) trace amine-associated re ( 337) 2286 383.0 5e-106
NP_778227 (OMIM: 608282) trace amine-associated re ( 348) 1052 182.8 9.2e-46
NP_778237 (OMIM: 608923) trace amine-associated re ( 345) 1025 178.4 1.9e-44
NP_444508 (OMIM: 606927) trace amine-associated re ( 342) 1019 177.5 3.7e-44
NP_001028252 (OMIM: 604849) trace amine-associated ( 351) 973 170.0 6.7e-42
NP_055441 (OMIM: 604849) trace amine-associated re ( 306) 923 161.8 1.7e-39
NP_612200 (OMIM: 609333) trace amine-associated re ( 339) 561 103.2 8.6e-22
NP_071640 (OMIM: 142703) histamine H2 receptor iso ( 359) 538 99.5 1.2e-20
XP_006714928 (OMIM: 142703) PREDICTED: histamine H ( 362) 538 99.5 1.2e-20
NP_001124527 (OMIM: 142703) histamine H2 receptor ( 397) 538 99.5 1.2e-20
XP_016864915 (OMIM: 142703) PREDICTED: histamine H ( 422) 538 99.6 1.3e-20
XP_011532851 (OMIM: 142703) PREDICTED: histamine H ( 422) 538 99.6 1.3e-20
XP_011532850 (OMIM: 142703) PREDICTED: histamine H ( 422) 538 99.6 1.3e-20
XP_005265961 (OMIM: 142703) PREDICTED: histamine H ( 422) 538 99.6 1.3e-20
XP_006714927 (OMIM: 142703) PREDICTED: histamine H ( 422) 538 99.6 1.3e-20
NP_000672 (OMIM: 104210) alpha-2A adrenergic recep ( 465) 398 76.9 9.2e-14
NP_001035262 (OMIM: 602164) 5-hydroxytryptamine re ( 360) 395 76.3 1.1e-13
NP_955525 (OMIM: 602164) 5-hydroxytryptamine recep ( 378) 395 76.3 1.2e-13
NP_001035259 (OMIM: 602164) 5-hydroxytryptamine re ( 387) 395 76.3 1.2e-13
NP_000861 (OMIM: 602164) 5-hydroxytryptamine recep ( 388) 395 76.3 1.2e-13
NP_001273339 (OMIM: 602164) 5-hydroxytryptamine re ( 411) 395 76.4 1.2e-13
NP_001035263 (OMIM: 602164) 5-hydroxytryptamine re ( 428) 395 76.4 1.2e-13
NP_001041 (OMIM: 182452) somatostatin receptor typ ( 369) 372 72.6 1.5e-12
NP_000674 (OMIM: 104250) alpha-2C adrenergic recep ( 462) 369 72.2 2.4e-12
NP_001138757 (OMIM: 600018) mu-type opioid recepto ( 389) 365 71.5 3.4e-12
NP_001008504 (OMIM: 600018) mu-type opioid recepto ( 392) 365 71.5 3.4e-12
NP_001138755 (OMIM: 600018) mu-type opioid recepto ( 397) 365 71.5 3.5e-12
NP_000905 (OMIM: 600018) mu-type opioid receptor i ( 400) 365 71.5 3.5e-12
NP_001138756 (OMIM: 600018) mu-type opioid recepto ( 403) 365 71.5 3.5e-12
NP_001138754 (OMIM: 600018) mu-type opioid recepto ( 406) 365 71.5 3.5e-12
NP_001272452 (OMIM: 600018) mu-type opioid recepto ( 414) 365 71.5 3.5e-12
NP_001008503 (OMIM: 600018) mu-type opioid recepto ( 418) 365 71.5 3.6e-12
NP_001138758 (OMIM: 600018) mu-type opioid recepto ( 420) 365 71.5 3.6e-12
NP_001008505 (OMIM: 600018) mu-type opioid recepto ( 446) 365 71.6 3.7e-12
NP_001272453 (OMIM: 600018) mu-type opioid recepto ( 493) 365 71.6 3.9e-12
NP_001138751 (OMIM: 600018) mu-type opioid recepto ( 493) 365 71.6 3.9e-12
XP_016884413 (OMIM: 182453) PREDICTED: somatostati ( 418) 363 71.2 4.5e-12
NP_001042 (OMIM: 182453) somatostatin receptor typ ( 418) 363 71.2 4.5e-12
XP_005261778 (OMIM: 182453) PREDICTED: somatostati ( 418) 363 71.2 4.5e-12
NP_001265616 (OMIM: 182453) somatostatin receptor ( 418) 363 71.2 4.5e-12
XP_011528651 (OMIM: 182453) PREDICTED: somatostati ( 418) 363 71.2 4.5e-12
XP_016884412 (OMIM: 182453) PREDICTED: somatostati ( 418) 363 71.2 4.5e-12
XP_006724374 (OMIM: 182453) PREDICTED: somatostati ( 418) 363 71.2 4.5e-12
NP_000015 (OMIM: 109690,600807,601665) beta-2 adre ( 413) 359 70.5 6.9e-12
NP_000902 (OMIM: 165195) delta-type opioid recepto ( 372) 352 69.3 1.4e-11
NP_000673 (OMIM: 104260,607876) alpha-2B adrenergi ( 450) 351 69.3 1.8e-11
NP_004239 (OMIM: 600895) prolactin-releasing pepti ( 370) 349 68.8 2e-11
NP_000855 (OMIM: 182133) 5-hydroxytryptamine recep ( 377) 344 68.0 3.6e-11
NP_057624 (OMIM: 605569) probable G-protein couple ( 423) 340 67.5 6e-11
NP_001243689 (OMIM: 312861) 5-hydroxytryptamine re ( 458) 340 67.5 6.2e-11
>>NP_003958 (OMIM: 607405) trace amine-associated recept (337 aa)
initn: 2286 init1: 2286 opt: 2286 Z-score: 2024.4 bits: 383.0 E(85289): 5e-106
Smith-Waterman score: 2286; 100.0% identity (100.0% similar) in 337 aa overlap (1-337:1-337)
10 20 30 40 50 60
pF1KE9 MRAVFIQGAEEHPAAFCYQVNGSCPRTVHTLGIQLVIYLACAAGMLIIVLGNVFVAFAVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MRAVFIQGAEEHPAAFCYQVNGSCPRTVHTLGIQLVIYLACAAGMLIIVLGNVFVAFAVS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE9 YFKALHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 YFKALHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCLT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE9 SIFHLCFISIDRHCAICDPLLYPSKFTVRVALRYILAGWGVPAAYTSLFLYTDVVETRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 SIFHLCFISIDRHCAICDPLLYPSKFTVRVALRYILAGWGVPAAYTSLFLYTDVVETRLS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE9 QWLEEMPCVGSCQLLLNKFWGWLNFPLFFVPCLIMISLYVKIFVVATRQAQQITTLSKSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QWLEEMPCVGSCQLLLNKFWGWLNFPLFFVPCLIMISLYVKIFVVATRQAQQITTLSKSL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE9 AGAAKHERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFDIFIWFAYFNSAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 AGAAKHERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFDIFIWFAYFNSAC
250 260 270 280 290 300
310 320 330
pF1KE9 NPIIYVFSYQWFRKALKLTLSQKVFSPQTRTVDLYQE
:::::::::::::::::::::::::::::::::::::
NP_003 NPIIYVFSYQWFRKALKLTLSQKVFSPQTRTVDLYQE
310 320 330
>>NP_778227 (OMIM: 608282) trace amine-associated recept (348 aa)
initn: 1100 init1: 690 opt: 1052 Z-score: 942.5 bits: 182.8 E(85289): 9.2e-46
Smith-Waterman score: 1052; 46.2% identity (75.5% similar) in 331 aa overlap (16-337:13-343)
10 20 30 40 50
pF1KE9 MRAVFIQGAEEHPAAFCYQ-VNGSCPRTVHTLGIQLVIYLACAAGMLIIVLGNVFVAFAV
.::. :: :: .: .. : . ..: . . : .. ..::..: .:.
NP_778 MVNNFSQAEAVELCYKNVNESCIKTPYSPGPRSILYAVLGFGAVLAAFGNLLVMIAI
10 20 30 40 50
60 70 80 90 100 110
pF1KE9 SYFKALHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCL
.:: ::::::::. ::: ::...:. :.:.::.:::::::.::: :..:: .:: ::.
NP_778 LHFKQLHTPTNFLIASLACADFLVGVTVMPFSTVRSVESCWYFGDSYCKFHTCFDTSFCF
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE9 TSIFHLCFISIDRHCAICDPLLYPSKFTVRVALRYILAGWGVPAAYTSLFLYTDVVETRL
.:.:::: ::.::. :. ::: ::.:::: :. :. .: ..:. ..:: . : .
NP_778 ASLFHLCCISVDRYIAVTDPLTYPTKFTVSVSGICIVLSWFFSVTYSFSIFYTGANEEGI
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE9 SQWLEEMPCVGSCQLLLNKFWGWLNFPLFFVPCLIMISLYVKIFVVATRQAQQI-TTLSK
. . . :::.:: ::. : : : :::.: . :. .: :::.:: .::..: .: :.
NP_778 EELVVALTCVGGCQAPLNQNWVLLCFLLFFIPNVAMVFIYSKIFLVAKHQARKIESTASQ
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE9 SLAGA-------AKHERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFDIFI
. ... ::.:::::::::::.. .:. :::. .:...:. ..::::: :..:..
NP_778 AQSSSESYKERVAKRERKAAKTLGIAMAAFLVSWLPYLVDAVIDAYMNFITPPYVYEILV
240 250 260 270 280 290
300 310 320 330
pF1KE9 WFAYFNSACNPIIYVFSYQWFRKALKLTLSQKVFSPQTRTVDLYQE
: .:.::: ::.::.: :::: ::.:: .: ::. .. :..:..:
NP_778 WCVYYNSAMNPLIYAFFYQWFGKAIKLIVSGKVLRTDSSTTNLFSEEVETD
300 310 320 330 340
>>NP_778237 (OMIM: 608923) trace amine-associated recept (345 aa)
initn: 1037 init1: 699 opt: 1025 Z-score: 918.9 bits: 178.4 E(85289): 1.9e-44
Smith-Waterman score: 1025; 43.8% identity (74.9% similar) in 331 aa overlap (16-337:13-343)
10 20 30 40 50
pF1KE9 MRAVFIQGAEEHPAAFCY-QVNGSCPRTVHTLGIQLVIYLACAAGMLIIVLGNVFVAFAV
.:: .::::: . . : ....:.. . : .. :.::..: ...
NP_778 MSSNSSLLVAVQLCYANVNGSCVKIPFSPGSRVILYIVFGFGAVLAVFGNLLVMISI
10 20 30 40 50
60 70 80 90 100 110
pF1KE9 SYFKALHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCL
.:: ::.:::::. ::: ::...:. :.:.: .:.:::::.:: .: .:: :. ::
NP_778 LHFKQLHSPTNFLVASLACADFLVGVTVMPFSMVRTVESCWYFGRSFCTFHTCCDVAFCY
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE9 TSIFHLCFISIDRHCAICDPLLYPSKFTVRVALRYILAGWGVPAAYTSLFLYTDVVETRL
.:.::::::::::. :. :::.::.:::: :. : ..: .: :.. .:: : . :
NP_778 SSLFHLCFISIDRYIAVTDPLVYPTKFTVSVSGICISVSWILPLMYSGAVFYTGVYDDGL
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE9 SQWLEEMPCVGSCQLLLNKFWGWLNFPLFFVPCLIMISLYVKIFVVATRQAQQI-TTLSK
. . . :.:.:: ..:. : .: ::.: .::: :: .::.:: :::..: .: ::
NP_778 EELSDALNCIGGCQTVVNQNWVLTDFLSFFIPTFIMIILYGNIFLVARRQAKKIENTGSK
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE9 SLAGA-------AKHERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFDIFI
. ... :..:::::::::..: ... :::..::...:... :::: ...:
NP_778 TESSSESYKARVARRERKAAKTLGVTVVAFMISWLPYSIDSLIDAFMGFITPACIYEICC
240 250 260 270 280 290
300 310 320 330
pF1KE9 WFAYFNSACNPIIYVFSYQWFRKALKLTLSQKVFSPQTRTVDLYQE
: ::.::: ::.::.. : :::::.:. .. .:.. .. :..:..:
NP_778 WCAYYNSAMNPLIYALFYPWFRKAIKVIVTGQVLKNSSATMNLFSEHI
300 310 320 330 340
>>NP_444508 (OMIM: 606927) trace amine-associated recept (342 aa)
initn: 1063 init1: 690 opt: 1019 Z-score: 913.7 bits: 177.5 E(85289): 3.7e-44
Smith-Waterman score: 1019; 44.1% identity (73.7% similar) in 331 aa overlap (16-337:12-342)
10 20 30 40 50
pF1KE9 MRAVFIQGAEEHPAAFCYQ-VNGSCPRTVHTLGIQLVIYLACAAGMLIIVLGNVFVAFAV
.::. ::::: .: .. : ....: : . : :. :.::..: .:
NP_444 MTSNFSQPVVQLCYEDVNGSCIETPYSPGSRVILYTAFSFGSLLAVFGNLLVMTSV
10 20 30 40 50
60 70 80 90 100 110
pF1KE9 SYFKALHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCL
.:: ::.:::::. ::: ::...:. :. .: .:.:::::.:: .: ::. :. ::
NP_444 LHFKQLHSPTNFLIASLACADFLVGVTVMLFSMVRTVESCWYFGAKFCTLHSCCDVAFCY
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE9 TSIFHLCFISIDRHCAICDPLLYPSKFTVRVALRYILAGWGVPAAYTSLFLYTDVVETRL
.:..::::: :::. .. :::.: .:::: :. : ..: .: .:.. .:: : . :
NP_444 SSVLHLCFICIDRYIVVTDPLVYATKFTVSVSGICISVSWILPLTYSGAVFYTGVNDDGL
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE9 SQWLEEMPCVGSCQLLLNKFWGWLNFPLFFVPCLIMISLYVKIFVVATRQAQQITTLSKS
. . . :::.::..... : ..: :::.: :.:: :: :::..: .:: .: : :..
NP_444 EELVSALNCVGGCQIIVSQGWVLIDFLLFFIPTLVMIILYSKIFLIAKQQAIKIETTSSK
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE9 LAGA--------AKHERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFDIFI
. .. ::.:::::::::..: ... :::.:.: ..:... :.:: ...:
NP_444 VESSSESYKIRVAKRERKAAKTLGVTVLAFVISWLPYTVDILIDAFMGFLTPAYIYEICC
240 250 260 270 280 290
300 310 320 330
pF1KE9 WFAYFNSACNPIIYVFSYQWFRKALKLTLSQKVFSPQTRTVDLYQE
: ::.::: ::.::.. : :::::.:: :: :.. .. :..:. :
NP_444 WSAYYNSAMNPLIYALFYPWFRKAIKLILSGDVLKASSSTISLFLE
300 310 320 330 340
>>NP_001028252 (OMIM: 604849) trace amine-associated rec (351 aa)
initn: 976 init1: 566 opt: 973 Z-score: 873.3 bits: 170.0 E(85289): 6.7e-42
Smith-Waterman score: 973; 43.3% identity (75.6% similar) in 307 aa overlap (21-326:30-336)
10 20 30 40 50
pF1KE9 MRAVFIQGAEEHPAAFCYQVNGSCPRTVHTLGIQLVIYLACAAGMLIIVLG
: :::.. ..::.....: :....: ..:
NP_001 MAVSSEQHELSHFKRTQTKKEKFNCSEYGNRSCPENERSLGVRVAMYSFMAGSIFITIFG
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE9 NVFVAFAVSYFKALHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHT
:. . ...:::: ::::::::.::.:..:..::. ..: : :::::.::.:: .:...
NP_001 NLAMIISISYFKQLHTPTNFLILSMAITDFLLGFTIMPYSMIRSVENCWYFGLTFCKIYY
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE9 YLDTLFCLTSIFHLCFISIDRHCAICDPLLYPSKFTVRVALRYILAGWGVPAAYTSLFLY
.: .. .::::::: ..::: ::: :::: .:.:. : : .: :.::.:.. ..
NP_001 SFDLMLSITSIFHLCSVAIDRFYAICYPLLYSTKITIPVIKRLLLLCWSVPGAFAFGVVF
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE9 TDVVETRLSQWLEEMPCVGSCQLLLNKFWGWLNFPL-FFVPCLIMISLYVKIFVVATRQA
... . . . : .:: ...::.:: : ::.: .:...: :::.:. ..:
NP_001 SEAYADGIEGYDILVACSSSCPVMFNKLWGTTLFMAGFFTPGSMMVGIYGKIFAVSRKHA
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE9 QQITTLSKSLAGAAKHERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFDIF
. :..: .. . .:...::::::::..:..::::.: . ..: .:.: :: ..:: .
NP_001 HAINNLRENQNNQVKKDKKAAKTLGIVIGVFLLCWFPCFFTILLDPFLNFSTPVVLFDAL
250 260 270 280 290 300
300 310 320 330
pF1KE9 IWFAYFNSACNPIIYVFSYQWFRKALKLTLSQKVFSPQTRTVDLYQE
::.::::.:::.:: : : :::.::: : :.::
NP_001 TWFGYFNSTCNPLIYGFFYPWFRRALKYILLGKIFSSCFHNTILCMQKESE
310 320 330 340 350
>>NP_055441 (OMIM: 604849) trace amine-associated recept (306 aa)
initn: 924 init1: 514 opt: 923 Z-score: 830.0 bits: 161.8 E(85289): 1.7e-39
Smith-Waterman score: 923; 43.6% identity (74.9% similar) in 291 aa overlap (37-326:1-291)
10 20 30 40 50 60
pF1KE9 QGAEEHPAAFCYQVNGSCPRTVHTLGIQLVIYLACAAGMLIIVLGNVFVAFAVSYFKALH
.: :....: ..::. . ...:::: ::
NP_055 MYSFMAGSIFITIFGNLAMIISISYFKQLH
10 20 30
70 80 90 100 110 120
pF1KE9 TPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCLTSIFHLC
::::::.::.:..:..::. ..: : :::::.::.:: .:... .: .. .:::::::
NP_055 TPTNFLILSMAITDFLLGFTIMPYSMIRSVENCWYFGLTFCKIYYSFDLMLSITSIFHLC
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE9 FISIDRHCAICDPLLYPSKFTVRVALRYILAGWGVPAAYTSLFLYTDVVETRLSQWLEEM
..::: ::: :::: .:.:. : : .: :.::.:.. ..... . . .
NP_055 SVAIDRFYAICYPLLYSTKITIPVIKRLLLLCWSVPGAFAFGVVFSEAYADGIEGYDILV
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE9 PCVGSCQLLLNKFWGWLNFPL-FFVPCLIMISLYVKIFVVATRQAQQITTLSKSLAGAAK
: .:: ...::.:: : ::.: .:...: :::.:. ..:. :..: .. . .:
NP_055 ACSSSCPVMFNKLWGTTLFMAGFFTPGSMMVGIYGKIFAVSRKHAHAINNLRENQNNQVK
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE9 HERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFDIFIWFAYFNSACNPIIY
...::::::::..:..::::.: . ..: .:.: :: ..:: . ::.::::.:::.::
NP_055 KDKKAAKTLGIVIGVFLLCWFPCFFTILLDPFLNFSTPVVLFDALTWFGYFNSTCNPLIY
220 230 240 250 260 270
310 320 330
pF1KE9 VFSYQWFRKALKLTLSQKVFSPQTRTVDLYQE
: : :::.::: : :.::
NP_055 GFFYPWFRRALKYILLGKIFSSCFHNTILCMQKESE
280 290 300
>>NP_612200 (OMIM: 609333) trace amine-associated recept (339 aa)
initn: 762 init1: 440 opt: 561 Z-score: 512.2 bits: 103.2 E(85289): 8.6e-22
Smith-Waterman score: 893; 39.0% identity (71.5% similar) in 333 aa overlap (16-337:4-336)
10 20 30 40 50
pF1KE9 MRAVFIQGAEEHPAAFCYQV-NGSCPRTVHTLGIQLVIYLACAAGMLIIVLGNVFVAFAV
::... : :: .. . .. .: . .: ..::..: ..
NP_612 MMPFCHNIINISCVKNNWSNDVRASLYSLMVLIILTTLVGNLIVIVSI
10 20 30 40
60 70 80 90 100 110
pF1KE9 SYFKALHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCL
:.:: ::::::.:. :.: .:..:: ::.: : .::.: ::.::. .:..:: : ..
NP_612 SHFKQLHTPTNWLIHSMATVDFLLGCLVMPYSMVRSAEHCWYFGEVFCKIHTSTDIMLSS
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE9 TSIFHLCFISIDRHCAICDPLLYPSKFTVRVALRYILAGWGVPAAYTSLFLYTDVVETRL
.::::: ::::::. :.:::: : .:... : .:. .:.:::... ... ..
NP_612 ASIFHLSFISIDRYYAVCDPLRYKAKMNILVICVMIFISWSVPAVFAFGMIFLELNFKGA
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE9 SQ-WLEEMPCVGSCQLLLNKFWGWLNFPL-FFVPCLIMISLYVKIFVVATRQAQQITTLS
. . ... : :.:.....:. : :.: :..: ::. .: .:...: .::. :. .
NP_612 EEIYYKHVHCRGGCSVFFSKISGVLTFMTSFYIPGSIMLCVYYRIYLIAKEQARLISDAN
170 180 190 200 210 220
240 250 260 270 280
pF1KE9 KSLA-------GAAK-HERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFDI
..: : .. .::::.:::::..:..:.:: :: : :..: .::.: :: . :.
NP_612 QKLQIGLEMKNGISQSKERKAVKTLGIVMGVFLICWCPFFICTVMDPFLHYIIPPTLNDV
230 240 250 260 270 280
290 300 310 320 330
pF1KE9 FIWFAYFNSACNPIIYVFSYQWFRKALKLTLSQKVFSPQTRTVDLYQE
.:::.:.::. ::..:.: : :::::::. : :.:. .. :. :
NP_612 LIWFGYLNSTFNPMVYAFFYPWFRKALKMMLFGKIFQKDSSRCKLFLELSS
290 300 310 320 330
>>NP_071640 (OMIM: 142703) histamine H2 receptor isoform (359 aa)
initn: 432 init1: 321 opt: 538 Z-score: 491.8 bits: 99.5 E(85289): 1.2e-20
Smith-Waterman score: 538; 35.7% identity (66.4% similar) in 283 aa overlap (34-313:18-296)
10 20 30 40 50 60
pF1KE9 VFIQGAEEHPAAFCYQVNGSCPRTVHTLGIQLVIYLACAAGMLIIVLGNVFVAFAVSYFK
...: .. :. .:: : ::: : .::. .
NP_071 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNR
10 20 30 40
70 80 90 100 110 120
pF1KE9 ALHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCLTSIF
:.. :: ...:::..:..:::::::.:.: .. : :: .: ..: ::...: .::.
NP_071 RLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASIL
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE9 HLCFISIDRHCAICDPLLYPSKFT-VRVALRYILAGWGVPAAYTSLFLYTDVVETRLSQW
.: .::.::.::. ::: :: : ::::. .: : . . : :: . . ..
NP_071 NLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLI-WVI--SITLSFLSIHLGWNSRNET
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE9 LEEMPCVGSCQLLLNKFWGWLN-FPLFFVPCLIMISLYVKIFVVATRQAQQITTLSKSLA
. ...:.. .:. .: .. . :..: ::: : .:: :: ::..:. .: :
NP_071 SKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHIS-SWK
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE9 GAAKHERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFD-IFIWFAYFNSAC
.:. .:.::. ::. ..: ...::.:. . .: . :.. : .:..: :::
NP_071 AATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSAL
230 240 250 260 270 280
310 320 330
pF1KE9 NPIIYVFSYQWFRKALKLTLSQKVFSPQTRTVDLYQE
:::.:. . ::
NP_071 NPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQ
290 300 310 320 330 340
>>XP_006714928 (OMIM: 142703) PREDICTED: histamine H2 re (362 aa)
initn: 432 init1: 321 opt: 538 Z-score: 491.8 bits: 99.5 E(85289): 1.2e-20
Smith-Waterman score: 538; 35.7% identity (66.4% similar) in 283 aa overlap (34-313:18-296)
10 20 30 40 50 60
pF1KE9 VFIQGAEEHPAAFCYQVNGSCPRTVHTLGIQLVIYLACAAGMLIIVLGNVFVAFAVSYFK
...: .. :. .:: : ::: : .::. .
XP_006 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNR
10 20 30 40
70 80 90 100 110 120
pF1KE9 ALHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCLTSIF
:.. :: ...:::..:..:::::::.:.: .. : :: .: ..: ::...: .::.
XP_006 RLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASIL
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE9 HLCFISIDRHCAICDPLLYPSKFT-VRVALRYILAGWGVPAAYTSLFLYTDVVETRLSQW
.: .::.::.::. ::: :: : ::::. .: : . . : :: . . ..
XP_006 NLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLI-WVI--SITLSFLSIHLGWNSRNET
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE9 LEEMPCVGSCQLLLNKFWGWLN-FPLFFVPCLIMISLYVKIFVVATRQAQQITTLSKSLA
. ...:.. .:. .: .. . :..: ::: : .:: :: ::..:. .: :
XP_006 SKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHIS-SWK
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE9 GAAKHERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFD-IFIWFAYFNSAC
.:. .:.::. ::. ..: ...::.:. . .: . :.. : .:..: :::
XP_006 AATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSAL
230 240 250 260 270 280
310 320 330
pF1KE9 NPIIYVFSYQWFRKALKLTLSQKVFSPQTRTVDLYQE
:::.:. . ::
XP_006 NPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQ
290 300 310 320 330 340
>>NP_001124527 (OMIM: 142703) histamine H2 receptor isof (397 aa)
initn: 432 init1: 321 opt: 538 Z-score: 491.4 bits: 99.5 E(85289): 1.2e-20
Smith-Waterman score: 538; 35.7% identity (66.4% similar) in 283 aa overlap (34-313:18-296)
10 20 30 40 50 60
pF1KE9 VFIQGAEEHPAAFCYQVNGSCPRTVHTLGIQLVIYLACAAGMLIIVLGNVFVAFAVSYFK
...: .. :. .:: : ::: : .::. .
NP_001 MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNR
10 20 30 40
70 80 90 100 110 120
pF1KE9 ALHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCLTSIF
:.. :: ...:::..:..:::::::.:.: .. : :: .: ..: ::...: .::.
NP_001 RLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASIL
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE9 HLCFISIDRHCAICDPLLYPSKFT-VRVALRYILAGWGVPAAYTSLFLYTDVVETRLSQW
.: .::.::.::. ::: :: : ::::. .: : . . : :: . . ..
NP_001 NLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLI-WVI--SITLSFLSIHLGWNSRNET
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE9 LEEMPCVGSCQLLLNKFWGWLN-FPLFFVPCLIMISLYVKIFVVATRQAQQITTLSKSLA
. ...:.. .:. .: .. . :..: ::: : .:: :: ::..:. .: :
NP_001 SKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHIS-SWK
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE9 GAAKHERKAAKTLGIAVGIYLLCWLPFTIDTMVDSLLHFITPPLVFD-IFIWFAYFNSAC
.:. .:.::. ::. ..: ...::.:. . .: . :.. : .:..: :::
NP_001 AATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSAL
230 240 250 260 270 280
310 320 330
pF1KE9 NPIIYVFSYQWFRKALKLTLSQKVFSPQTRTVDLYQE
:::.:. . ::
NP_001 NPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQ
290 300 310 320 330 340
337 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 16:29:47 2016 done: Sun Nov 6 16:29:48 2016
Total Scan time: 7.100 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]