FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE9284, 327 aa
  1>>>pF1KE9284 327 - 327 aa - 327 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 4.9459+/-0.000391; mu= 18.2527+/- 0.024
 mean_var=68.4498+/-14.218, 0's: 0 Z-trim(112.1): 34  B-trim: 942 in 1/54
 Lambda= 0.155020
 statistics sampled from 20927 (20953) to 20927 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.611), E-opt: 0.2 (0.246), width:  16
 Scan time:  6.110

The best scores are:                                      opt bits E(85289)
NP_006824 (OMIM: 614729) COP9 signalosome complex  ( 327) 2135 486.6 3.1e-137
NP_002802 (OMIM: 157970) 26S proteasome non-ATPase ( 324)  366 90.9 3.8e-18
NP_003745 (OMIM: 603914) eukaryotic translation in ( 357)  354 88.3 2.7e-17


>>NP_006824 (OMIM: 614729) COP9 signalosome complex subu  (327 aa)
 initn: 2135 init1: 2135 opt: 2135  Z-score: 2584.8  bits: 486.6 E(85289): 3.1e-137
Smith-Waterman score: 2135; 100.0% identity (100.0% similar) in 327 aa overlap (1-327:1-327)

               10        20        30        40        50        60
pF1KE9 MAAAAAAAAATNGTGGSSGMEVDAAVVPSVMACGVTGSVSVALHPLVILNISDHWIRMRS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MAAAAAAAAATNGTGGSSGMEVDAAVVPSVMACGVTGSVSVALHPLVILNISDHWIRMRS
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE9 QEGRPVQVIGALIGKQEGRNIEVMNSFELLSHTVEEKIIIDKEYYYTKEEQFKQVFKELE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 QEGRPVQVIGALIGKQEGRNIEVMNSFELLSHTVEEKIIIDKEYYYTKEEQFKQVFKELE
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE9 FLGWYTTGGPPDPSDIHVHKQVCEIIESPLFLKLNPMTKHTDLPVSVFESVIDIINGEAT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 FLGWYTTGGPPDPSDIHVHKQVCEIIESPLFLKLNPMTKHTDLPVSVFESVIDIINGEAT
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE9 MLFAELTYTLATEEAERIGVDHVARMTATGSGENSTVAEHLIAQHSAIKMLHSRVKLILE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MLFAELTYTLATEEAERIGVDHVARMTATGSGENSTVAEHLIAQHSAIKMLHSRVKLILE
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE9 YVKASEAGEVPFNHEILREAYALCHCLPVLSTDKFKTDFYDQCNDVGLMAYLGTITKTCN
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 YVKASEAGEVPFNHEILREAYALCHCLPVLSTDKFKTDFYDQCNDVGLMAYLGTITKTCN
              250       260       270       280       290       300

              310       320       
pF1KE9 TMNQFVNKFNVLYDRQGIGRRMRGLFF
       :::::::::::::::::::::::::::
NP_006 TMNQFVNKFNVLYDRQGIGRRMRGLFF
              310       320       

>>NP_002802 (OMIM: 157970) 26S proteasome non-ATPase reg  (324 aa)
 initn: 299 init1: 182 opt: 366  Z-score: 446.7  bits: 90.9 E(85289): 3.8e-18
Smith-Waterman score: 366; 26.4% identity (63.7% similar) in 273 aa overlap (41-307:9-277)

               20        30        40        50        60        70
pF1KE9 TNGTGGSSGMEVDAAVVPSVMACGVTGSVSVALHPLVILNISDHWIRMRSQEGRPVQVIG
                                     :..::::.:.. ::. :. .. :   .:.:
NP_002                       MPELAVQKVVVHPLVLLSVVDHFNRI-GKVGNQKRVVG
                                     10        20         30       

               80         90         100       110       120       
pF1KE9 ALIGKQEGRNIEVMNSFEL-LSHTVEEKII--IDKEYYYTKEEQFKQVFKELEFLGWYTT
       .:.:. . . ..: ::: . ...  ..  .  .:..:  .   .::.:  . ...::: :
NP_002 VLLGSWQKKVLDVSNSFAVPFDEDDKDDSVWFLDHDYLENMYGMFKKVNARERIVGWYHT
        40        50        60        70        80        90       

       130       140       150       160       170        180      
pF1KE9 GGPPDPSDIHVHKQVCEIIESPLFLKLNPMTKHTDLPVSVFESVIDIIN-GEATM-LFAE
       :     .:: ... . .   . ... ..   :   ::. .. :: .. . :  :   : .
NP_002 GPKLHKNDIAINELMKRYCPNSVLVIIDVKPKDLGLPTEAYISVEEVHDDGTPTSKTFEH
       100       110       120       130       140       150       

         190       200        210       220       230       240    
pF1KE9 LTYTLATEEAERIGVDHVAR-MTATGSGENSTVAEHLIAQHSAIKMLHSRVKLILEYVKA
       .:  ...::::..::.:. : .  :  :   :.....  :  ..: :.:..  :  :.. 
NP_002 VTSEIGAEEAEEVGVEHLLRDIKDTTVG---TLSQRITNQVHGLKGLNSKLLDIRSYLEK
       160       170       180          190       200       210    

          250       260       270       280       290       300    
pF1KE9 SEAGEVPFNHEILREAYALCHCLPVLSTDKFKTDFYDQCNDVGLMAYLGTITKTCNTMNQ
         .:..:.::.:. .   . . :: .: ..:   :: . ::  ...::... ..  ....
NP_002 VATGKLPINHQIIYQLQDVFNLLPDVSLQEFVKAFYLKTNDQMVVVYLASLIRSVVALHN
          220       230       240       250       260       270    

          310       320                                  
pF1KE9 FVNKFNVLYDRQGIGRRMRGLFF                           
       ..:                                               
NP_002 LINNKIANRDAEKKEGQEKEESKKDRKEDKEKDKDKEKSDVKKEEKKEKK
          280       290       300       310       320    

>>NP_003745 (OMIM: 603914) eukaryotic translation initia  (357 aa)
 initn: 296 init1: 131 opt: 354  Z-score: 431.6  bits: 88.3 E(85289): 2.7e-17
Smith-Waterman score: 354; 25.7% identity (59.8% similar) in 311 aa overlap (2-307:50-356)

                                            10        20           
pF1KE9                              MAAAAAAAAATNGTGGSSGM--EVDAAVVPS
                                     ::::::.:: . : .:.    .. : ..:.
NP_003 AAAPASVPAPTPAPAAAPVPAAAPASSSDPAAAAAATAAPGQTPASAQAPAQTPAPALPG
      20        30        40        50        60        70         

      30         40        50        60        70        80        
pF1KE9 VMACG-VTGSVSVALHPLVILNISDHWIRMRSQEGRPVQVIGALIGKQEGRNIEVMNSFE
           :   :.  : :::... .: : .   : .::  ..:::.:.:  . ...:: : : 
NP_003 PALPGPFPGGRVVRLHPVILASIVDSY--ERRNEG-AARVIGTLLGTVDKHSVEVTNCFS
      80        90       100         110        120       130      

       90       100       110       120       130       140        
pF1KE9 LLSHTVEEKIIIDKEYYYTKEEQFKQVFKELEFLGWYTTGGPPDPSDIHVHKQVCEIIES
       .  .  :... .: :.  .  :  :.:  .  .::::.::      .. .:.   .   .
NP_003 VPHNESEDEVAVDMEFAKNMYELHKKVSPNELILGWYATGHDITEHSVLIHEYYSREAPN
        140       150       160       170       180       190      

      150       160       170       180        190       200       
pF1KE9 PLFLKLNPMTKHTDLPVSVFESVIDIINGEAT-MLFAELTYTLATEEAERIGVDHVARMT
       :. : ..   ..  . .... :..  . :..  ..:. ::   :  ..:::::: . . :
NP_003 PIHLTVDTSLQNGRMSIKAYVSTLMGVPGRTMGVMFTPLTVKYAYYDTERIGVDLIMK-T
        200       210       220       230       240       250      

       210       220       230       240       250       260       
pF1KE9 ATGSGENSTVAEHLIAQHSAIKMLHSRVKLILEYVKASEAGEVPFNHEILREAYALCHCL
         . ..   ..  :    .:   ... .. .:.:..   .:.:  .. . :  ..: . .
NP_003 CFSPNRVIGLSSDLQQVGGASARIQDALSTVLQYAEDVLSGKVSADNTVGRFLMSLVNQV
         260       270       280       290       300       310     

       270       280       290       300        310       320      
pF1KE9 PVLSTDKFKTDFYDQCNDVGLMAYLGTITKTCNTMNQ-FVNKFNVLYDRQGIGRRMRGLF
       : .  : :.: . .. ::. ...::...:..  ..:. .::                   
NP_003 PKIVPDDFETMLNSNINDLLMVTYLANLTQSQIALNEKLVNL                  
         320       330       340       350                         

        
pF1KE9 F




327 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Tue Nov  8 10:25:18 2016 done: Tue Nov  8 10:25:19 2016
 Total Scan time:  6.110 Total Display time: -0.030

Function used was FASTA [36.3.4 Apr, 2011]