Result of FASTA (omim) for
pFN21AE6770
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6770, 555 aa
1>>>pF1KE6770 555 - 555 aa - 555 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4002+/-0.000353; mu= 18.7976+/- 0.022
mean_var=71.7706+/-14.393, 0's: 0 Z-trim(113.4): 31 B-trim: 0 in 0/54
Lambda= 0.151391
statistics sampled from 22688 (22716) to 22688 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.639), E-opt: 0.2 (0.266), width: 16
Scan time: 5.180
The best scores are: opt bits E(85289)
NP_005699 (OMIM: 258315,604404) glypican-6 precurs ( 555) 3741 826.5 0
XP_016875787 (OMIM: 258315,604404) PREDICTED: glyp ( 485) 3259 721.2 1.8e-207
XP_011519346 (OMIM: 258315,604404) PREDICTED: glyp ( 485) 3259 721.2 1.8e-207
XP_016875788 (OMIM: 258315,604404) PREDICTED: glyp ( 485) 3259 721.2 1.8e-207
XP_016875789 (OMIM: 258315,604404) PREDICTED: glyp ( 485) 3259 721.2 1.8e-207
XP_016875790 (OMIM: 258315,604404) PREDICTED: glyp ( 433) 2930 649.3 7.1e-186
NP_001439 (OMIM: 194070,300168,312870) glypican-4 ( 556) 2422 538.4 2.2e-152
XP_016875791 (OMIM: 258315,604404) PREDICTED: glyp ( 324) 1756 392.8 8.7e-109
NP_002072 (OMIM: 600395) glypican-1 precursor [Hom ( 558) 1320 297.7 6.3e-80
XP_011509278 (OMIM: 600395) PREDICTED: glypican-1 ( 486) 1048 238.3 4.3e-62
XP_016875924 (OMIM: 602446) PREDICTED: glypican-5 ( 565) 756 174.5 7.7e-43
NP_004457 (OMIM: 602446) glypican-5 precursor [Hom ( 572) 756 174.5 7.8e-43
XP_011519356 (OMIM: 602446) PREDICTED: glypican-5 ( 480) 745 172.1 3.6e-42
XP_011519362 (OMIM: 602446) PREDICTED: glypican-5 ( 443) 698 161.8 4.1e-39
XP_011519361 (OMIM: 602446) PREDICTED: glypican-5 ( 444) 698 161.8 4.1e-39
XP_016875926 (OMIM: 602446) PREDICTED: glypican-5 ( 444) 698 161.8 4.1e-39
XP_011519357 (OMIM: 602446) PREDICTED: glypican-5 ( 444) 698 161.8 4.1e-39
XP_016875925 (OMIM: 602446) PREDICTED: glypican-5 ( 444) 698 161.8 4.1e-39
XP_011519358 (OMIM: 602446) PREDICTED: glypican-5 ( 444) 698 161.8 4.1e-39
XP_011519360 (OMIM: 602446) PREDICTED: glypican-5 ( 444) 698 161.8 4.1e-39
XP_011519359 (OMIM: 602446) PREDICTED: glypican-5 ( 444) 698 161.8 4.1e-39
NP_004475 (OMIM: 194070,300037,312870) glypican-3 ( 580) 687 159.5 2.7e-38
XP_016884902 (OMIM: 194070,300037,312870) PREDICTE ( 486) 640 149.2 2.9e-35
NP_001158089 (OMIM: 194070,300037,312870) glypican ( 603) 569 133.7 1.6e-30
NP_001158091 (OMIM: 194070,300037,312870) glypican ( 526) 558 131.3 7.6e-30
NP_001158090 (OMIM: 194070,300037,312870) glypican ( 564) 555 130.6 1.3e-29
>>NP_005699 (OMIM: 258315,604404) glypican-6 precursor [ (555 aa)
initn: 3741 init1: 3741 opt: 3741 Z-score: 4413.7 bits: 826.5 E(85289): 0
Smith-Waterman score: 3741; 100.0% identity (100.0% similar) in 555 aa overlap (1-555:1-555)
10 20 30 40 50 60
pF1KE6 MPSWIGAVILPLLGLLLSLPAGADVKARSCGEVRQAYGAKGFSLADIPYQEIAGEHLRIC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MPSWIGAVILPLLGLLLSLPAGADVKARSCGEVRQAYGAKGFSLADIPYQEIAGEHLRIC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 PQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVSRHKKFDEFFRELLENAEKSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVSRHKKFDEFFRELLENAEKSL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 NDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEMLNDFWARLLERMFQLINPQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 NDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEMLNDFWARLLERMFQLINPQY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 HFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAARTFVQGLTVGREVANRVSKVSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 HFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAARTFVQGLTVGREVANRVSKVSP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 TPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLANQADLDTEWNLFIDAMLLVAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLANQADLDTEWNLFIDAMLLVAE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 RLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQGCGQPKPAPALRSARSAPENF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQGCGQPKPAPALRSARSAPENF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 NTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWSALPYTICKDESVTAGTSNEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 NTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWSALPYTICKDESVTAGTSNEE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 ECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFIRQQIMALRVMTNKLKNAYNG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFIRQQIMALRVMTNKLKNAYNG
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 NDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAVDPDRREVDSSAAQRGHSLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 NDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAVDPDRREVDSSAAQRGHSLLS
490 500 510 520 530 540
550
pF1KE6 WSLTCIVLALQRLCR
:::::::::::::::
NP_005 WSLTCIVLALQRLCR
550
>>XP_016875787 (OMIM: 258315,604404) PREDICTED: glypican (485 aa)
initn: 3259 init1: 3259 opt: 3259 Z-score: 3845.6 bits: 721.2 E(85289): 1.8e-207
Smith-Waterman score: 3259; 100.0% identity (100.0% similar) in 485 aa overlap (71-555:1-485)
50 60 70 80 90 100
pF1KE6 GFSLADIPYQEIAGEHLRICPQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVS
::::::::::::::::::::::::::::::
XP_016 MEDKLSQQSKLEFENLVEETSHFVRTTFVS
10 20 30
110 120 130 140 150 160
pF1KE6 RHKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RHKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEM
40 50 60 70 80 90
170 180 190 200 210 220
pF1KE6 LNDFWARLLERMFQLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAART
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNDFWARLLERMFQLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAART
100 110 120 130 140 150
230 240 250 260 270 280
pF1KE6 FVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLAN
160 170 180 190 200 210
290 300 310 320 330 340
pF1KE6 QADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQG
220 230 240 250 260 270
350 360 370 380 390 400
pF1KE6 CGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWS
280 290 300 310 320 330
410 420 430 440 450 460
pF1KE6 ALPYTICKDESVTAGTSNEEECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALPYTICKDESVTAGTSNEEECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFI
340 350 360 370 380 390
470 480 490 500 510 520
pF1KE6 RQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAV
400 410 420 430 440 450
530 540 550
pF1KE6 DPDRREVDSSAAQRGHSLLSWSLTCIVLALQRLCR
:::::::::::::::::::::::::::::::::::
XP_016 DPDRREVDSSAAQRGHSLLSWSLTCIVLALQRLCR
460 470 480
>>XP_011519346 (OMIM: 258315,604404) PREDICTED: glypican (485 aa)
initn: 3259 init1: 3259 opt: 3259 Z-score: 3845.6 bits: 721.2 E(85289): 1.8e-207
Smith-Waterman score: 3259; 100.0% identity (100.0% similar) in 485 aa overlap (71-555:1-485)
50 60 70 80 90 100
pF1KE6 GFSLADIPYQEIAGEHLRICPQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVS
::::::::::::::::::::::::::::::
XP_011 MEDKLSQQSKLEFENLVEETSHFVRTTFVS
10 20 30
110 120 130 140 150 160
pF1KE6 RHKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RHKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEM
40 50 60 70 80 90
170 180 190 200 210 220
pF1KE6 LNDFWARLLERMFQLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAART
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LNDFWARLLERMFQLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAART
100 110 120 130 140 150
230 240 250 260 270 280
pF1KE6 FVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLAN
160 170 180 190 200 210
290 300 310 320 330 340
pF1KE6 QADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQG
220 230 240 250 260 270
350 360 370 380 390 400
pF1KE6 CGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWS
280 290 300 310 320 330
410 420 430 440 450 460
pF1KE6 ALPYTICKDESVTAGTSNEEECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALPYTICKDESVTAGTSNEEECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFI
340 350 360 370 380 390
470 480 490 500 510 520
pF1KE6 RQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAV
400 410 420 430 440 450
530 540 550
pF1KE6 DPDRREVDSSAAQRGHSLLSWSLTCIVLALQRLCR
:::::::::::::::::::::::::::::::::::
XP_011 DPDRREVDSSAAQRGHSLLSWSLTCIVLALQRLCR
460 470 480
>>XP_016875788 (OMIM: 258315,604404) PREDICTED: glypican (485 aa)
initn: 3259 init1: 3259 opt: 3259 Z-score: 3845.6 bits: 721.2 E(85289): 1.8e-207
Smith-Waterman score: 3259; 100.0% identity (100.0% similar) in 485 aa overlap (71-555:1-485)
50 60 70 80 90 100
pF1KE6 GFSLADIPYQEIAGEHLRICPQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVS
::::::::::::::::::::::::::::::
XP_016 MEDKLSQQSKLEFENLVEETSHFVRTTFVS
10 20 30
110 120 130 140 150 160
pF1KE6 RHKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RHKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEM
40 50 60 70 80 90
170 180 190 200 210 220
pF1KE6 LNDFWARLLERMFQLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAART
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNDFWARLLERMFQLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAART
100 110 120 130 140 150
230 240 250 260 270 280
pF1KE6 FVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLAN
160 170 180 190 200 210
290 300 310 320 330 340
pF1KE6 QADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQG
220 230 240 250 260 270
350 360 370 380 390 400
pF1KE6 CGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWS
280 290 300 310 320 330
410 420 430 440 450 460
pF1KE6 ALPYTICKDESVTAGTSNEEECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALPYTICKDESVTAGTSNEEECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFI
340 350 360 370 380 390
470 480 490 500 510 520
pF1KE6 RQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAV
400 410 420 430 440 450
530 540 550
pF1KE6 DPDRREVDSSAAQRGHSLLSWSLTCIVLALQRLCR
:::::::::::::::::::::::::::::::::::
XP_016 DPDRREVDSSAAQRGHSLLSWSLTCIVLALQRLCR
460 470 480
>>XP_016875789 (OMIM: 258315,604404) PREDICTED: glypican (485 aa)
initn: 3259 init1: 3259 opt: 3259 Z-score: 3845.6 bits: 721.2 E(85289): 1.8e-207
Smith-Waterman score: 3259; 100.0% identity (100.0% similar) in 485 aa overlap (71-555:1-485)
50 60 70 80 90 100
pF1KE6 GFSLADIPYQEIAGEHLRICPQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVS
::::::::::::::::::::::::::::::
XP_016 MEDKLSQQSKLEFENLVEETSHFVRTTFVS
10 20 30
110 120 130 140 150 160
pF1KE6 RHKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RHKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEM
40 50 60 70 80 90
170 180 190 200 210 220
pF1KE6 LNDFWARLLERMFQLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAART
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNDFWARLLERMFQLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAART
100 110 120 130 140 150
230 240 250 260 270 280
pF1KE6 FVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLAN
160 170 180 190 200 210
290 300 310 320 330 340
pF1KE6 QADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQG
220 230 240 250 260 270
350 360 370 380 390 400
pF1KE6 CGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWS
280 290 300 310 320 330
410 420 430 440 450 460
pF1KE6 ALPYTICKDESVTAGTSNEEECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALPYTICKDESVTAGTSNEEECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFI
340 350 360 370 380 390
470 480 490 500 510 520
pF1KE6 RQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAV
400 410 420 430 440 450
530 540 550
pF1KE6 DPDRREVDSSAAQRGHSLLSWSLTCIVLALQRLCR
:::::::::::::::::::::::::::::::::::
XP_016 DPDRREVDSSAAQRGHSLLSWSLTCIVLALQRLCR
460 470 480
>>XP_016875790 (OMIM: 258315,604404) PREDICTED: glypican (433 aa)
initn: 2930 init1: 2930 opt: 2930 Z-score: 3458.0 bits: 649.3 E(85289): 7.1e-186
Smith-Waterman score: 2930; 100.0% identity (100.0% similar) in 433 aa overlap (123-555:1-433)
100 110 120 130 140 150
pF1KE6 FVRTTFVSRHKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTG
::::::::::::::::::::::::::::::
XP_016 MFVRTYGMLYMQNSEVFQDLFTELKRYYTG
10 20 30
160 170 180 190 200 210
pF1KE6 GNVNLEEMLNDFWARLLERMFQLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GNVNLEEMLNDFWARLLERMFQLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVT
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE6 RAFIAARTFVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RAFIAARTFVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLN
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE6 VMKGCLANQADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VMKGCLANQADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQ
160 170 180 190 200 210
340 350 360 370 380 390
pF1KE6 VSAKVFQGCGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSAKVFQGCGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKL
220 230 240 250 260 270
400 410 420 430 440 450
pF1KE6 KLSKKVWSALPYTICKDESVTAGTSNEEECWNGHSKARYLPEIMNDGLTNQINNPEVDVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLSKKVWSALPYTICKDESVTAGTSNEEECWNGHSKARYLPEIMNDGLTNQINNPEVDVD
280 290 300 310 320 330
460 470 480 490 500 510
pF1KE6 ITRPDTFIRQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ITRPDTFIRQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEF
340 350 360 370 380 390
520 530 540 550
pF1KE6 VTTEAPAVDPDRREVDSSAAQRGHSLLSWSLTCIVLALQRLCR
:::::::::::::::::::::::::::::::::::::::::::
XP_016 VTTEAPAVDPDRREVDSSAAQRGHSLLSWSLTCIVLALQRLCR
400 410 420 430
>>NP_001439 (OMIM: 194070,300168,312870) glypican-4 prec (556 aa)
initn: 2398 init1: 1676 opt: 2422 Z-score: 2856.7 bits: 538.4 E(85289): 2.2e-152
Smith-Waterman score: 2422; 64.5% identity (86.1% similar) in 546 aa overlap (9-552:9-553)
10 20 30 40 50 60
pF1KE6 MPSWIGAVILPLLGLLLSLPAGADVKARSCGEVRQAYGAKGFSLADIPYQEIAGEHLRIC
.: :..: . .:..:..::.:::. : .:::. : : .:: :.::.::
NP_001 MARFGLPALLCTLAVLSAALLAAELKSKSCSEVRRLYVSKGFNKNDAPLHEINGDHLKIC
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 PQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVSRHKKFDEFFRELLENAEKSL
:: :::. :::.: : ::: .:...: : . ....:.::.:::::::.::::::::::
NP_001 PQGSTCCSQEMEEKYSLQSKDDFKSVVSEQCNHLQAVFASRYKKFDEFFKELLENAEKSL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 NDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEMLNDFWARLLERMFQLINPQY
:::::.::: :::::::.:.:::.::::::. :::::::::::::::::::::.:.: ::
NP_001 NDMFVKTYGHLYMQNSELFKDLFVELKRYYVVGNVNLEEMLNDFWARLLERMFRLVNSQY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 HFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAARTFVQGLTVGREVANRVSKVSP
::...:::::::::.:::::::::::::.::::::.:::::.:::.:. .:...:: :.:
NP_001 HFTDEYLECVSKYTEQLKPFGDVPRKLKLQVTRAFVAARTFAQGLAVAGDVVSKVSVVNP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 TPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLANQADLDTEWNLFIDAMLLVAE
: : .::.::.:: .:::: ::.:: ::: :.:.::::::.::: ::: ::::::.:::
NP_001 TAQCTHALLKMIYCSHCRGLVTVKPCYNYCSNIMRGCLANQGDLDFEWNNFIDAMLMVAE
250 260 270 280 290 300
310 320 330 340 350
pF1KE6 RLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQGCGQPKPAPALRSARSAPEN-
::::::::::::::::::::.::::::.::.::: ::::::: ::: :: : .:: :.
NP_001 RLEGPFNIESVMDPIDVKISDAIMNMQDNSVQVSQKVFQGCGPPKPLPAGRISRSISESA
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE6 FNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWSALPYTICKDESVTAGTSNE
:..::::..:::::::::::::::::::.::::: .:: ::.:: ..:.:: ..::..::
NP_001 FSARFRPHHPEERPTTAAGTSLDRLVTDVKEKLKQAKKFWSSLPSNVCNDERMAAGNGNE
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE6 EECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFIRQQIMALRVMTNKLKNAYN
..::::..:.::: . ..::.:: :::::.:: ..:: .: .:::::::::.:.:::::
NP_001 DDCWNGKGKSRYLFAVTGNGLANQGNNPEVQVDTSKPDILILRQIMALRVMTSKMKNAYN
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE6 GNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAVDPDRREVDSSAAQRGHSLL
::::.: : :::::: :::::: . ::.::.. .:. . . ... .::.... : .
NP_001 GNDVDFFDISDESSGEGSGSGCEYQQCPSEFDYNATDHAGKSANEK-ADSAGVRPGAQAY
490 500 510 520 530
540 550
pF1KE6 SWSLTCIV-LALQRLCR
.. ::. :..::
NP_001 LLTVFCILFLVMQREWR
540 550
>>XP_016875791 (OMIM: 258315,604404) PREDICTED: glypican (324 aa)
initn: 1756 init1: 1756 opt: 1756 Z-score: 2074.0 bits: 392.8 E(85289): 8.7e-109
Smith-Waterman score: 1756; 100.0% identity (100.0% similar) in 263 aa overlap (293-555:62-324)
270 280 290 300 310 320
pF1KE6 VRPCNNYCLNVMKGCLANQADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEA
::::::::::::::::::::::::::::::
XP_016 QGLWGNSITGRRNSRCKAWRQDCIWLCPDPDAMLLVAERLEGPFNIESVMDPIDVKISEA
40 50 60 70 80 90
330 340 350 360 370 380
pF1KE6 IMNMQENSMQVSAKVFQGCGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IMNMQENSMQVSAKVFQGCGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLD
100 110 120 130 140 150
390 400 410 420 430 440
pF1KE6 RLVTDIKEKLKLSKKVWSALPYTICKDESVTAGTSNEEECWNGHSKARYLPEIMNDGLTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLVTDIKEKLKLSKKVWSALPYTICKDESVTAGTSNEEECWNGHSKARYLPEIMNDGLTN
160 170 180 190 200 210
450 460 470 480 490 500
pF1KE6 QINNPEVDVDITRPDTFIRQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QINNPEVDVDITRPDTFIRQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCM
220 230 240 250 260 270
510 520 530 540 550
pF1KE6 DDVCPTEFEFVTTEAPAVDPDRREVDSSAAQRGHSLLSWSLTCIVLALQRLCR
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DDVCPTEFEFVTTEAPAVDPDRREVDSSAAQRGHSLLSWSLTCIVLALQRLCR
280 290 300 310 320
>>NP_002072 (OMIM: 600395) glypican-1 precursor [Homo sa (558 aa)
initn: 1719 init1: 1204 opt: 1320 Z-score: 1555.9 bits: 297.7 E(85289): 6.3e-80
Smith-Waterman score: 1766; 49.1% identity (80.3% similar) in 503 aa overlap (4-506:9-499)
10 20 30 40 50
pF1KE6 MPSWIGAVILPLLGLLLSLPAGADVKARSCGEVRQAYGAKGFSLADIPYQEIAGE
:. . :.. . ::. :.:::::::: ::::::::.:.: ::.::
NP_002 MELRARGWWLLCAAAALVACARGDPAS---KSRSCGEVRQIYGAKGFSLSDVPQAEISGE
10 20 30 40 50
60 70 80 90 100 110
pF1KE6 HLRICPQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVSRHKKFDEFFRELLEN
::::::: :::::.:::..:...:. :.:. ....:. ... .... ..::. :..::..
NP_002 HLRICPQGYTCCTSEMEENLANRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLND
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE6 AEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEMLNDFWARLLERMFQL
.:..:. : ..: :: ::...:.::..::. :: :.:..::: : .::::::::.:.
NP_002 SERTLQATFPGAFGELYTQNARAFRDLYSELRLYYRGANLHLEETLAEFWARLLERLFKQ
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE6 INPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAARTFVQGLTVGREVANRV
..:: . .:::.:..: .. :.:::..::.:....::::.:::.::::: :. .:. .:
NP_002 LHPQLLLPDDYLDCLGKQAEALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKV
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE6 SKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLANQADLDTEWNLFIDAM
..: : : ::.::..:: .: :.: .::: .:: ::.:::::::::::.:: ..:.:
NP_002 AQVPLGPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVLKGCLANQADLDAEWRNLLDSM
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE6 LLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQGCGQPKPAPALRSARS
.:..... : ..:::. . . ..::: .:.: ..:::.::::.:: :
NP_002 VLITDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVIQGCGNPKVNP----QGP
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE6 APENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWSALPYTICKDESVTAG
.::. : . :.::: . :: :..::.. : .:. . : .:: :.:. :... .
NP_002 GPEEKRRRGK-LAPRERPPS--GT-LEKLVSEAKAQLRDVQDFWISLPGTLCS-EKMALS
360 370 380 390 400
420 430 440 450 460 470
pF1KE6 TSNEEECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFIRQQIMALRVMTNKLK
:.....:::: ...:::::.:.:::.::::::::.::::.:: :::::: :..:::.:.
NP_002 TASDDRCWNGMARGRYLPEVMGDGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLR
410 420 430 440 450 460
480 490 500 510 520 530
pF1KE6 NAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAVDPDRREVDSSAAQRG
.:::::::.:::.::..::::::.::.::.:
NP_002 SAYNGNDVDFQDASDDGSGSGSGDGCLDDLCSRKVSRKSSSSRTPLTHALPGLSEQEGQK
470 480 490 500 510 520
540 550
pF1KE6 HSLLSWSLTCIVLALQRLCR
NP_002 TSAASCPQPPTFLLPLLLFLALTVARPRWR
530 540 550
>>XP_011509278 (OMIM: 600395) PREDICTED: glypican-1 isof (486 aa)
initn: 1406 init1: 891 opt: 1048 Z-score: 1235.7 bits: 238.3 E(85289): 4.3e-62
Smith-Waterman score: 1494; 47.5% identity (81.0% similar) in 436 aa overlap (71-506:1-427)
50 60 70 80 90 100
pF1KE6 GFSLADIPYQEIAGEHLRICPQEYTCCTTEMEDKLSQQSKLEFENLVEETSHFVRTTFVS
::..:...:. :.:. ....:. ... ...
XP_011 MEENLANRSHAELETALRDSSRVLQAMLAT
10 20 30
110 120 130 140 150 160
pF1KE6 RHKKFDEFFRELLENAEKSLNDMFVRTYGMLYMQNSEVFQDLFTELKRYYTGGNVNLEEM
. ..::. :..::...:..:. : ..: :: ::...:.::..::. :: :.:..:::
XP_011 QLRSFDDHFQHLLNDSERTLQATFPGAFGELYTQNARAFRDLYSELRLYYRGANLHLEET
40 50 60 70 80 90
170 180 190 200 210 220
pF1KE6 LNDFWARLLERMFQLINPQYHFSEDYLECVSKYTDQLKPFGDVPRKLKIQVTRAFIAART
: .::::::::.:. ..:: . .:::.:..: .. :.:::..::.:....::::.:::.
XP_011 LAEFWARLLERLFKQLHPQLLLPDDYLDCLGKQAEALRPFGEAPRELRLRATRAFVAARS
100 110 120 130 140 150
230 240 250 260 270 280
pF1KE6 FVQGLTVGREVANRVSKVSPTPGCIRALMKMLYCPYCRGLPTVRPCNNYCLNVMKGCLAN
::::: :. .:. .:..: : : ::.::..:: .: :.: .::: .:: ::.::::::
XP_011 FVQGLGVASDVVRKVAQVPLGPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVLKGCLAN
160 170 180 190 200 210
290 300 310 320 330 340
pF1KE6 QADLDTEWNLFIDAMLLVAERLEGPFNIESVMDPIDVKISEAIMNMQENSMQVSAKVFQG
:::::.:: ..:.:.:..... : ..:::. . . ..::: .:.: ..:::.::
XP_011 QADLDAEWRNLLDSMVLITDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVIQG
220 230 240 250 260 270
350 360 370 380 390 400
pF1KE6 CGQPKPAPALRSARSAPENFNTRFRPYNPEERPTTAAGTSLDRLVTDIKEKLKLSKKVWS
::.:: : .::. : . :.::: . :: :..::.. : .:. . :
XP_011 CGNPKVNPQ----GPGPEEKRRRGK-LAPRERPPS--GT-LEKLVSEAKAQLRDVQDFWI
280 290 300 310 320
410 420 430 440 450 460
pF1KE6 ALPYTICKDESVTAGTSNEEECWNGHSKARYLPEIMNDGLTNQINNPEVDVDITRPDTFI
.:: :.:. :... .:.....:::: ...:::::.:.:::.::::::::.::::.:: :
XP_011 SLPGTLCS-EKMALSTASDDRCWNGMARGRYLPEVMGDGLANQINNPEVEVDITKPDMTI
330 340 350 360 370 380
470 480 490 500 510 520
pF1KE6 RQQIMALRVMTNKLKNAYNGNDVNFQDTSDESSGSGSGSGCMDDVCPTEFEFVTTEAPAV
::::: :..:::.:..:::::::.:::.::..::::::.::.::.:
XP_011 RQQIMQLKIMTNRLRSAYNGNDVDFQDASDDGSGSGSGDGCLDDLCSRKVSRKSSSSRTP
390 400 410 420 430 440
530 540 550
pF1KE6 DPDRREVDSSAAQRGHSLLSWSLTCIVLALQRLCR
XP_011 LTHALPGLSEQEGQKTSAASCPQPPTFLLPLLLFLALTVARPRWR
450 460 470 480
555 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 16:12:35 2016 done: Tue Nov 8 16:12:36 2016
Total Scan time: 5.180 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]