Result of FASTA (ccds) for
pFN21AE6742
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6742, 1427 aa
1>>>pF1KE6742 1427 - 1427 aa - 1427 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.1189+/-0.000911; mu= 22.1371+/- 0.055
mean_var=143.3145+/-28.302, 0's: 0 Z-trim(111.5): 92 B-trim: 0 in 0/51
Lambda= 0.107134
statistics sampled from 12309 (12403) to 12309 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.715), E-opt: 0.2 (0.381), width: 16
Scan time: 4.420
The best scores are: opt bits E(32554)
CCDS6970.1 ADAMTS13 gene_id:11093|Hs108|chr9 (1427) 10218 1592.2 0
CCDS6972.1 ADAMTS13 gene_id:11093|Hs108|chr9 (1371) 8210 1281.8 0
CCDS6971.1 ADAMTS13 gene_id:11093|Hs108|chr9 (1340) 6056 948.9 0
CCDS33524.1 ADAMTS1 gene_id:9510|Hs108|chr21 ( 967) 1087 180.7 1.8e-44
CCDS41732.1 ADAMTS8 gene_id:11095|Hs108|chr11 ( 889) 1029 171.7 8.5e-42
CCDS1223.1 ADAMTS4 gene_id:9507|Hs108|chr1 ( 837) 1016 169.7 3.3e-41
CCDS7307.1 ADAMTS14 gene_id:140766|Hs108|chr10 (1226) 997 166.9 3.2e-40
CCDS13579.1 ADAMTS5 gene_id:11096|Hs108|chr21 ( 930) 986 165.1 8.8e-40
CCDS7306.1 ADAMTS14 gene_id:140766|Hs108|chr10 (1223) 979 164.1 2.2e-39
CCDS31778.2 ADAMTS20 gene_id:80070|Hs108|chr12 (1910) 937 157.9 2.7e-37
CCDS8488.1 ADAMTS15 gene_id:170689|Hs108|chr11 ( 950) 931 156.6 3.2e-37
CCDS4444.1 ADAMTS2 gene_id:9509|Hs108|chr5 (1211) 875 148.1 1.5e-34
CCDS3553.1 ADAMTS3 gene_id:9508|Hs108|chr4 (1205) 865 146.5 4.4e-34
CCDS10383.1 ADAMTS17 gene_id:170691|Hs108|chr15 (1095) 862 146.0 5.7e-34
CCDS43299.1 ADAMTS16 gene_id:170690|Hs108|chr5 (1224) 825 140.3 3.2e-32
CCDS10926.1 ADAMTS18 gene_id:170692|Hs108|chr16 (1221) 817 139.1 7.6e-32
CCDS82801.1 ADAMTS9 gene_id:56999|Hs108|chr3 (1907) 803 137.1 4.6e-31
CCDS2903.1 ADAMTS9 gene_id:56999|Hs108|chr3 (1935) 803 137.2 4.6e-31
CCDS47954.1 ADAMTSL1 gene_id:92949|Hs108|chr9 (1762) 612 107.6 3.4e-22
CCDS34311.1 ADAMTS2 gene_id:9509|Hs108|chr5 ( 566) 527 93.9 1.4e-18
CCDS4146.1 ADAMTS19 gene_id:171019|Hs108|chr5 (1207) 513 92.1 1.1e-17
CCDS34140.1 ADAMTS12 gene_id:81792|Hs108|chr5 (1594) 450 82.5 1.1e-14
CCDS6485.1 ADAMTSL1 gene_id:92949|Hs108|chr9 ( 525) 415 76.5 2.2e-13
CCDS32303.1 ADAMTS7 gene_id:11173|Hs108|chr15 (1686) 414 77.0 5.3e-13
CCDS30852.1 ADAMTSL4 gene_id:54507|Hs108|chr1 ( 877) 398 74.2 1.9e-12
CCDS955.1 ADAMTSL4 gene_id:54507|Hs108|chr1 (1074) 398 74.3 2.2e-12
CCDS72908.1 ADAMTSL4 gene_id:54507|Hs108|chr1 (1097) 398 74.3 2.2e-12
CCDS73773.1 ADAMTSL3 gene_id:57188|Hs108|chr15 (1682) 393 73.7 5e-12
CCDS10326.1 ADAMTSL3 gene_id:57188|Hs108|chr15 (1691) 393 73.7 5.1e-12
>>CCDS6970.1 ADAMTS13 gene_id:11093|Hs108|chr9 (1427 aa)
initn: 10218 init1: 10218 opt: 10218 Z-score: 8537.2 bits: 1592.2 E(32554): 0
Smith-Waterman score: 10218; 100.0% identity (100.0% similar) in 1427 aa overlap (1-1427:1-1427)
10 20 30 40 50 60
pF1KE6 MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 PSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 PSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 GAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 GAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 FDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 FDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 PGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 PGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTEC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 GVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 GVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 RACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 RACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 ALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 ALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE6 VWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 VWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE6 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE6 YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE6 TVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 TVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE6 PPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 PPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE6 PVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 PVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPA
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE6 AGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 AGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLA
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE6 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMS
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE6 LGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 LGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGT
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE6 WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGTPSLVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGTPSLVP
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE6 HEEAAAPGRTTATPAGASLEWSQARGLLFSPAPQPRRLLPGPQENSVQSSACGRQHLEPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 HEEAAAPGRTTATPAGASLEWSQARGLLFSPAPQPRRLLPGPQENSVQSSACGRQHLEPT
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE6 GTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRKLLDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 GTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRKLLDM
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE6 TFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLSPATS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 TFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLSPATS
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE6 NAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQVLYWE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 NAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQVLYWE
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420
pF1KE6 SESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT
:::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 SESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT
1390 1400 1410 1420
>>CCDS6972.1 ADAMTS13 gene_id:11093|Hs108|chr9 (1371 aa)
initn: 8210 init1: 8210 opt: 8210 Z-score: 6860.1 bits: 1281.8 E(32554): 0
Smith-Waterman score: 9719; 96.1% identity (96.1% similar) in 1427 aa overlap (1-1427:1-1371)
10 20 30 40 50 60
pF1KE6 MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 PSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 PSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 GAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 GAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 FDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 FDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 PGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 PGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTEC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 GVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 GVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 RACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 RACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 ALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 ALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQ
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE6 VWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 VWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE6 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE6 YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE6 TVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 TVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTL
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE6 PPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 PPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE6 PVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 PVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPA
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE6 AGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 AGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLA
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE6 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMS
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE6 LGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 LGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGT
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE6 WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGTPSLVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQG------
1090 1100 1110 1120 1130
1150 1160 1170 1180 1190 1200
pF1KE6 HEEAAAPGRTTATPAGASLEWSQARGLLFSPAPQPRRLLPGPQENSVQSSACGRQHLEPT
::::::::::
CCDS69 --------------------------------------------------ACGRQHLEPT
1140
1210 1220 1230 1240 1250 1260
pF1KE6 GTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRKLLDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 GTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRKLLDM
1150 1160 1170 1180 1190 1200
1270 1280 1290 1300 1310 1320
pF1KE6 TFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLSPATS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 TFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLSPATS
1210 1220 1230 1240 1250 1260
1330 1340 1350 1360 1370 1380
pF1KE6 NAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQVLYWE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 NAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQVLYWE
1270 1280 1290 1300 1310 1320
1390 1400 1410 1420
pF1KE6 SESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT
:::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 SESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT
1330 1340 1350 1360 1370
>>CCDS6971.1 ADAMTS13 gene_id:11093|Hs108|chr9 (1340 aa)
initn: 6046 init1: 6046 opt: 6056 Z-score: 5061.0 bits: 948.9 E(32554): 0
Smith-Waterman score: 9400; 93.9% identity (93.9% similar) in 1427 aa overlap (1-1427:1-1340)
10 20 30 40 50 60
pF1KE6 MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 PSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 PSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 GAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 GAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 FDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 FDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQ
::::::::::::::::::::::::::::::::::::
CCDS69 GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSA------------------------
250 260 270
310 320 330 340 350 360
pF1KE6 PGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTEC
:::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 -------NEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTEC
280 290 300 310 320
370 380 390 400 410 420
pF1KE6 GVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 GVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGG
330 340 350 360 370 380
430 440 450 460 470 480
pF1KE6 RACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 RACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGD
390 400 410 420 430 440
490 500 510 520 530 540
pF1KE6 ALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 ALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQ
450 460 470 480 490 500
550 560 570 580 590 600
pF1KE6 VWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 VWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIG
510 520 530 540 550 560
610 620 630 640 650 660
pF1KE6 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR
570 580 590 600 610 620
670 680 690 700 710 720
pF1KE6 YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 YGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVE
630 640 650 660 670 680
730 740 750 760 770 780
pF1KE6 TVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 TVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTL
690 700 710 720 730 740
790 800 810 820 830 840
pF1KE6 PPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 PPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEA
750 760 770 780 790 800
850 860 870 880 890 900
pF1KE6 PVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 PVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWTPA
810 820 830 840 850 860
910 920 930 940 950 960
pF1KE6 AGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 AGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLA
870 880 890 900 910 920
970 980 990 1000 1010 1020
pF1KE6 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 ACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCPPRWKVMS
930 940 950 960 970 980
1030 1040 1050 1060 1070 1080
pF1KE6 LGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 LGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTYRWHVGT
990 1000 1010 1020 1030 1040
1090 1100 1110 1120 1130 1140
pF1KE6 WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQGTPSLVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 WMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPCVGQG------
1050 1060 1070 1080 1090 1100
1150 1160 1170 1180 1190 1200
pF1KE6 HEEAAAPGRTTATPAGASLEWSQARGLLFSPAPQPRRLLPGPQENSVQSSACGRQHLEPT
::::::::::
CCDS69 --------------------------------------------------ACGRQHLEPT
1110
1210 1220 1230 1240 1250 1260
pF1KE6 GTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRKLLDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 GTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNCSAGDMLLLWGRLTWRKMCRKLLDM
1120 1130 1140 1150 1160 1170
1270 1280 1290 1300 1310 1320
pF1KE6 TFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLSPATS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 TFSSKTNTLVVRQRCGRPGGGVLLRYGSQLAPETFYRECDMQLFGPWGEIVSPSLSPATS
1180 1190 1200 1210 1220 1230
1330 1340 1350 1360 1370 1380
pF1KE6 NAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQVLYWE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 NAGGCRLFINVAPHARIAIHALATNMGAGTEGANASYILIRDTHSLRTTAFHGQQVLYWE
1240 1250 1260 1270 1280 1290
1390 1400 1410 1420
pF1KE6 SESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT
:::::::::::::::::::::::::::::::::::::::::::::::
CCDS69 SESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPEMQDPQSWKGKEGT
1300 1310 1320 1330 1340
>>CCDS33524.1 ADAMTS1 gene_id:9510|Hs108|chr21 (967 aa)
initn: 804 init1: 283 opt: 1087 Z-score: 911.9 bits: 180.7 E(32554): 1.8e-44
Smith-Waterman score: 1235; 30.2% identity (56.7% similar) in 786 aa overlap (51-804:230-966)
30 40 50 60 70
pF1KE6 CGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAP-LKG--RPPSPGFQRQRQRQRRAAG
:: : :.: .: . : :..: ..
CCDS33 VVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVGQPTGTG----SIRKKRFVS
200 210 220 230 240 250
80 90 100 110 120 130
pF1KE6 GILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEP
. ..: .... .. . : ..:.:: ....:.: . ::. . . .::.... .
CCDS33 SHRYVETMLVADQSMAEFHGSGLKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVIHDE
260 270 280 290 300 310
140 150 160 170 180 190
pF1KE6 EGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGNRQVRGVTQ
. .:..:.: . .: . :.:.. :: .: : : : .. .:: :: . . .. :...
CCDS33 QKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDL-CGSQTCDTLGMAD
320 330 340 350 360 370
200 210 220 230 240 250
pF1KE6 LGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPG----SGCGPSGHVMASDG
.: .:.:. :: . :: :.. . : :::.:: :.. :: : .: . ..:.:::
CCDS33 VGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHDDAKQCASLNGVNQDSHMMASML
380 390 400 410 420 430
260 270 280 290 300 310
pF1KE6 AAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQPGLYYSANEQCRV
. . ::::: .. :.:. :...:. : :. .: . : :: :.::.::.
CCDS33 SNLDHSQPWSPCSAYMITSFLDNGHGECLMDKPQ-NPIQL---PGDLPGTSYDANRQCQF
440 450 460 470 480 490
320 330 340 350 360 370
pF1KE6 AFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRS
.:: . : : . :..: : :. : ::: :: ::: .:.: .
CCDS33 TFGEDSKHCPDAA---STCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWCINGKCVN
500 510 520 530 540
380 390 400 410 420 430
pF1KE6 LVELTPI-AAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEM
.. . . :: :. ::: . :::.::::: :.:.:: : ::. : : .. .
CCDS33 KTDRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRS
550 560 570 580 590 600
440 450 460 470 480
pF1KE6 CNTQAC-EKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDA---LCRHMCR
:: . : ... : .:: .. .. ..: :.. .: .:. : . :. .:.
CCDS33 CNLEDCPDNNGKTFREEQC-EAHNEFSKASFGSGPAVEW---IPKYAGVSPKDRCKLICQ
610 620 630 640 650 660
490 500 510 520 530 540
pF1KE6 A--IGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQ
: :: :... . .::: : : :.: :.::.:.: ::: .::.. .:.:
CCDS33 AKGIGYFFVLQ--PKVVDGTPCSP-----DST-SVCVQGQCVKAGCDRIIDSKKKFDKCG
670 680 690 700 710
550 560 570 580 590 600
pF1KE6 VCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIA--NHRPLFTH---LAVRIG-
::::..:::. .:: :... : ..:. . :.. . :.: .. ::.. .
CCDS33 VCGGNGSTCKKISGSVTSAKPG-YHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAAD
720 730 740 750 760 770
610 620 630 640 650 660
pF1KE6 GRYVVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRR
: :.. : ...: : ... : : : . . ::.:: ..::.: :::
CCDS33 GTYILNGDYTLS--TLEQDIMYKGVV-LRYSGSS---AALERIRSFSPLKEPLTIQVLT-
780 790 800 810 820
670 680 690 700
pF1KE6 YGEEYGNLTRPDITFTYFQPKPRQ---------AWV---WAAVRGPCSVSCGAGLRWVNY
:: :: : .::: : .. ::: : : :: :: : .
CCDS33 ----VGNALRPKIKYTYFVKKKKESFNAIPTFSAWVIEEW----GECSKSCELGWQRRLV
830 840 850 860 870
710 720 730 740 750 760
pF1KE6 SCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVR
: : . : : ... :: . :. .::: : .:... :: .:: : ..: ..
CCDS33 ECRDINGQPASE---C-AKEVKPASTRPCADHPCPQ-WQLGEWSSCSKTCGKGYKKRSLK
880 890 900 910 920 930
770 780 790 800 810 820
pF1KE6 CVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALEN
:. .:..:. : ..: .. :. :
CCDS33 CLSHDGGVLSH---ESCDP-LKKPKHFIDFCTMAECS
940 950 960
830 840 850 860 870 880
pF1KE6 ETCVPGADGLEAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIR
>>CCDS41732.1 ADAMTS8 gene_id:11095|Hs108|chr11 (889 aa)
initn: 946 init1: 290 opt: 1029 Z-score: 863.9 bits: 171.7 E(32554): 8.5e-42
Smith-Waterman score: 1103; 28.9% identity (53.7% similar) in 765 aa overlap (60-805:201-888)
30 40 50 60 70 80
pF1KE6 PSHFQQSCLQALEPQAVSSYLSPGAPLKGRPPSPGFQRQRQRQRRAAGGILHLELLVAVG
:: : .: .: .. .: :...
CCDS41 TGEGQRQERGDHQEDSEEESQEEEAEGASEPPPP--LGATSRTKRFVSEARFVETLLVAD
180 190 200 210 220
90 100 110 120 130 140
pF1KE6 PDVFQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTS
.. . : . ..:: ....:.. . ::. .. . .::..:. . . .:... :
CCDS41 ASMAAFYGADLQNHILTLMSVAARIYKHPSIKNSINLMVVKVLIVEDEKWGPEVSDNGGL
230 240 250 260 270 280
150 160 170 180 190 200
pF1KE6 SLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGNRQVRGVTQLGGACSPTWSCL
.: . :.:.. .: .: : : : .. .:: .. .: .. ::...: :.:. ::
CCDS41 TLRNFCNWQRRFNQPSDRHPEHYDTAILLTRQNFCGQEGLCDTLGVADIGTICDPNKSCS
290 300 310 320 330 340
210 220 230 240 250 260
pF1KE6 ITEDTGFDLGVTIAHEIGHSFGLEHDGA-PGSGC-GPSG--HVMASDGAAPRAGLAWSPC
. :: :.. . :.:::.:: ... :: . : . :: : :::: . : ::::
CCDS41 VIEDEGLQAAHTLAHELGHVLSMPHDDSKPCTRLFGPMGKHHVMAPLFVHLNQTLPWSPC
350 360 370 380 390 400
270 280 290 300 310 320
pF1KE6 SRRQLLSLLSAGRARCVWDPPRPQPGSAGHP-PDAQPGLY--YSANEQCRVAFGPKAVAC
: : ::..:.. :. : : .:. : : . :: . :. ..::: ::: :
CCDS41 SAMYLTELLDGGHGDCLLDAP-----AAALPLPTGLPGRMALYQLDQQCRQIFGPDFRHC
410 420 430 440 450 460
330 340 350 360 370
pF1KE6 TFAREHLDMCQALSCHTD---PLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVELT-
. . :.: : :::: :: ... . : : ::: :: . ::.: : :.
CCDS41 PNTSAQ-DVCAQLWCHTDGAEPLCHTKNGSL--PWADGTPCGPGHLCSEGSCLPEEEVER
470 480 490 500 510 520
380 390 400 410 420 430
pF1KE6 PIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQAC
: .. : :. ::: . :::.::::: .:.:..:.: ::: :.: . . :.:. :
CCDS41 PKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEEC
530 540 550 560 570 580
440 450 460 470 480 490
pF1KE6 EKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDA---LCRHMCRAIGESFI
: ::: . .. . : .. .: ::. : . :. .::: :.: .
CCDS41 PPDGKSFREQQCEKYNAYNYTDMDG--NLLQW---VPKYAGVSPRDRCKLFCRARGRSEF
590 600 610 620 630
500 510 520 530 540 550
pF1KE6 MKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTC
. .::: : ::. ::..:: :.: ::: .:: . :.: :::: ...:
CCDS41 KVFEAKVIDGTLC---GPE---TLAICVRGQCVKAGCDHVVDSPRKLDKCGVCGGKGNSC
640 650 660 670 680
560 570 580 590 600 610
pF1KE6 SPRKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIGGRYVVA----GKMSI
.::.: : ..:. . :.. . .. .: .:. : :.. :.. .
CCDS41 RKVSGSLTP-TNYGYNDIVTIPAGATNIDVKQR----SHPGVQNDGNYLALKTADGQYLL
690 700 710 720 730 740
620 630 640 650 660 670
pF1KE6 SPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRP
. : . .. .: :. . . ::... . :: : .:. :: . :
CCDS41 NGNLAISAIEQDILVKGTILKYSGSIATLERLQSFRPLPEPLTVQLLTVPGEVFP----P
750 760 770 780 790 800
680 690 700 710 720 730
pF1KE6 DITFTYFQPKPRQAWVWAAVRGPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPP
. .:.: :. :..: :. :: . :
CCDS41 KVKYTFFVPND-----------------------VDFSM--QSSKERATT----------
810 820
740 750 760 770 780 790
pF1KE6 AWPEACVLEPC-PPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQ
...: :..::.. ::..::.: ..: :.: . .:. : : :
CCDS41 -----NIIQPLLHAQWVLGDWSECSSTCGAGWQRRTVECRDPSGQ-----ASATCNK-AL
830 840 850 860 870
800 810 820 830 840 850
pF1KE6 QPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVD
.: : . :. : ::
CCDS41 KPEDA-KPCESQLCPL
880
>>CCDS1223.1 ADAMTS4 gene_id:9507|Hs108|chr1 (837 aa)
initn: 843 init1: 204 opt: 1016 Z-score: 853.3 bits: 169.7 E(32554): 3.3e-41
Smith-Waterman score: 1034; 31.1% identity (54.9% similar) in 679 aa overlap (38-682:162-805)
10 20 30 40 50 60
pF1KE6 ARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGA-------PLKGRP
:: :: . .: .::: : .:.
CCDS12 INGDPESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPGAHILRRKSPASGQG
140 150 160 170 180 190
70 80 90 100 110
pF1KE6 P-----SP-GFQRQRQRQ-RRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAE
: .: : : :. .: :. .: ::.. . : .::.:: . .:.
CCDS12 PMCNVKAPLGSPSPRPRRAKRFASLSRFVETLVVADDKMAAFHGAGLKRYLLTVMAAAAK
200 210 220 230 240 250
120 130 140 150 160 170
pF1KE6 LLRDPSLGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHAD
.. ::. . ....::: : .:.. . ...: : :.:.. .: .:.:: : :
CCDS12 AFKHPSIRNPVSLVVTRLVILGSGEEGPQVGPSAAQTLRSFCAWQRGLNTPEDSDPDHFD
260 270 280 290 300 310
180 190 200 210 220 230
pF1KE6 LVLYITRFDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLE
.. .:: :: .. .. :....: .:.:. :: :.:: :.. . : :::.:: :..
CCDS12 TAILFTRQDL-CGVSTCDTLGMADVGTVCDPARSCAIVEDDGLQSAFTAAHELGHVFNML
320 330 340 350 360 370
240 250 260 270 280
pF1KE6 HDGAPG--SGCGP---SGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRP
::.. : :: : :::: : ::::: : . ..:. : ..:. :
CCDS12 HDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEPWSPCSARFITDFLDNGYGHCLLD----
380 390 400 410 420
290 300 310 320 330 340
pF1KE6 QPGSAGHPPDAQPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCS
.: . : : . :: :.:..::...::: . : . : :: : .. :.
CCDS12 KPEAPLHLPVTFPGKDYDADRQCQLTFGPDSRHCP---QLPPPCAALWCSGHLNGHAMCQ
430 440 450 460 470 480
350 360 370 380 390 400
pF1KE6 RLLVPLLDGTECGVEKWCSKGRCRSLVELTPIAAVH-GRWSSWGPRSPCSRSCGGGVVTR
: ::: :: . : ::: . .: . . : :. ::: . :::.:::::
CCDS12 TKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQAGGWGPWGPWGDCSRTCGGGVQFS
490 500 510 520 530 540
410 420 430 440 450 460
pF1KE6 RRQCNNPRPAFGGRACVGADLQAEMCNTQACEK-TQLEFMSQQCA----RTDGQPLRSSP
:.:. : : ::. : : . . :::. : . : : .::: ::: ..: :
CCDS12 SRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFREEQCAAYNHRTDL--FKSFP
550 560 570 580 590 600
470 480 490 500 510
pF1KE6 GGASFY-HWGAAVPHSQGDALCRHMCRA--IGESFIMKRGDSFLDGTRCMPSGPREDGTL
: .. .. ...:..: :. :.: .: .... .::: : : :..
CCDS12 GPMDWVPRYTGVAPQDQ----CKLTCQAQALGYYYVLE--PRVVDGTPCSP-----DSS-
610 620 630 640
520 530 540 550 560 570
pF1KE6 SLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPN
:.::.: : ::: . :.. .:.:.:::::.: :: ..::: : : . .:. .
CCDS12 SVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKFR-YGYNNVVTIPAG
650 660 670 680 690 700
580 590 600 610 620 630
pF1KE6 LTSVYI-----ANHRPLFTHLAVRI-GGRYVVAGKMSISPNTTYPSLLEDGRVEYRVALT
: . . .:: .. ::... : :.. :.... :. : ... : : : .
CCDS12 ATHILVRQQGNPGHRSIY--LALKLPDGSYALNGEYTLMPSPT--DVVLPGAVSLRYS--
710 720 730 740 750 760
640 650 660 670 680 690
pF1KE6 EDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPKPRQAWVWAAVRG
: . ::: . .:: :: . ...: :.:
CCDS12 -GATAASETLSGHGPLAQPLTLQVLVA-----GNPQDTRLRYSFFVPRPTPSTPRPTPQD
770 780 790 800 810
700 710 720 730 740 750
pF1KE6 PCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGP
CCDS12 WLHRRAQILEILRRRPWAGRK
820 830
>>CCDS7307.1 ADAMTS14 gene_id:140766|Hs108|chr10 (1226 aa)
initn: 1077 init1: 298 opt: 997 Z-score: 835.5 bits: 166.9 E(32554): 3.2e-40
Smith-Waterman score: 1313; 29.5% identity (55.5% similar) in 892 aa overlap (70-933:248-1092)
40 50 60 70 80 90
pF1KE6 ALEPQAVSSYLSPGAPLKGRPPSPGFQRQRQRQRR-AAGGILHLELLVAVGPDVFQAH-Q
.:.:: : : .:.:..: .: . : .
CCDS73 EPDGDLHNEAFGLGDLPNLLGLVGDQLGDTERKRRHAKPGSYSIEVLLVVDDSVVRFHGK
220 230 240 250 260 270
100 110 120 130 140 150
pF1KE6 EDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNIT-ANLTSSLLSVCG
: .. :::: .:: :. .: :::... . ::..... .. : .: . :: .::
CCDS73 EHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCR
280 290 300 310 320 330
160 170 180 190 200 210
pF1KE6 WSQTINPEDDTDPGHADLVLYITRFDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGF
:... . .: . : : :...:: :. :.: ..: . . : : : :: .... ::
CCDS73 WAHSQQRQDPSHAEHHDHVVFLTRQDFG-PSG---MQGYAPVTGMCHPLRSCALNHEDGF
340 350 360 370 380 390
220 230 240 250 260 270
pF1KE6 DLGVTIAHEIGHSFGLEHDGAPGSGCGPS---GHVMASDGAAPRAGLAWSPCSRRQLLSL
. . .:::: :: .:.:::: :.::. : ::: : . :: ::. .:
CCDS73 SSAFVIAHETGHVLGMEHDGQ-GNGCADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRY
400 410 420 430 440 450
280 290 300 310 320 330
pF1KE6 LSAGRARCVWDPPRPQPGSAGHPPDAQPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQ
: . :. : : .: . .::. ::. :: .:::: :: .: .: . .. :.
CCDS73 LPS--YDCLLDDPF-DP-AWPQPPEL-PGINYSMDEQCRFDFGSGYQTC-LAFRTFEPCK
460 470 480 490 500
340 350 360 370 380 390
pF1KE6 ALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVELTPIAAV--HGRWSSWG
: : . : . :. : ::::::. ::: ::.: . .: . : ::::
CCDS73 QLWC-SHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHC---IWKSPEQTYGQDGGWSSWT
510 520 530 540 550 560
400 410 420 430 440 450
pF1KE6 PRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCA
. ::::::::: .: :.:::: ::.::: :.: .. ..::.. : : .: .::::
CCDS73 KFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQQCA
570 580 590 600 610 620
460 470 480 490 500
pF1KE6 RTDGQPLRSSPGGASFYHWGAAVPHSQGDAL--CRHMCRAIGESFIMKRGDSFLDGTRCM
. .. .... . : ::. : :. .:.. . .. .. :::::
CCDS73 KRNSYYVHQNAK----HSW---VPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRCS
630 640 650 660 670
510 520 530 540 550 560
pF1KE6 PSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSF-TAGRAR
: :.:. : : ::: .. :... :.: ::::::: : ::.. :..
CCDS73 YRDPY-----SVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQA
680 690 700 710 720 730
570 580 590 600 610 620
pF1KE6 EYVTFLTVTPNLTSVYIANHRPLFTHLAVR--IGGRYVVAGKMSISPNTTYPSL---LED
. .. . . . : . ...:. . : ... : . . . :. .. ::
CCDS73 GALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEWED
740 750 760 770 780 790
630 640 650 660 670 680
pF1KE6 GRVEYRVAL-TEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPKP
. . . .: : ::. : : . .. .: . : : : . .
CCDS73 AVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLL--PLIGSNNVLLEE
800 810 820 830 840
690 700 710 720 730 740
pF1KE6 RQAWVWAAVR-GPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEP
... :: .::: .::.:.....:.: . ...:. :. ...: . : .:
CCDS73 MDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHP
850 860 870 880 890 900
750 760 770 780 790
pF1KE6 CP-PYWAVGDFGPCSASCGG-GLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETC
: : :.. ..: :: ::: :.. : ..:. .. . . ::. :: ..: : . :
CCDS73 CSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAG-DRPE-ARRPC
910 920 930 940 950 960
800 810 820 830 840 850
pF1KE6 NPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPC
::::.:... :.:... : :. .. .: .:..: . : .: . :
CCDS73 LRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTV-------QVC
970 980 990 1000 1010
860 870 880 890 900 910
pF1KE6 VGMSCPPGWGHLDATSAGE--KAPSPWGSIRTGAQAAHVWT------PAAGSCSVSCGRG
.: : .: ..: .. . .: :. .. : . : .:. :: :
CCDS73 SLPAC--GGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQ--
1020 1030 1040 1050 1060 1070
920 930 940 950 960 970
pF1KE6 LMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVV
::. .: .: ..::
CCDS73 -MEV----LDRYCSIPGYHRLCCVSCIKKASGPNPGPDPGPTSLPPFSTPGSPLPGPQDP
1080 1090 1100 1110 1120 1130
>>CCDS13579.1 ADAMTS5 gene_id:11096|Hs108|chr21 (930 aa)
initn: 539 init1: 238 opt: 986 Z-score: 827.7 bits: 165.1 E(32554): 8.8e-40
Smith-Waterman score: 1050; 29.5% identity (54.4% similar) in 743 aa overlap (30-742:223-930)
10 20 30 40 50
pF1KE6 MHQRHPRARCPPLCVAGILACGFLLGCWGPSHFQQSCLQALEPQAVS-SYLSPGAPLKG
:.: . : :: : .. : :::.. :
CCDS13 YTREGFSFEALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLDQSALSPAG---G
200 210 220 230 240
60 70 80 90 100 110
pF1KE6 RPPSPGFQRQRQRQRRAAGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDP
:. ..:.:. :: ..:::... .. . . . ..:.:: .:. .:
CCDS13 SGPQTWWRRRRRSISRAR----QVELLLVADASMARLYGRGLQHYLLTLASIANRLYSHA
250 260 270 280 290 300
120 130 140 150 160 170
pF1KE6 SLGAQFRVHLVKMVILTEPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYI
:. ..:. .::.:.: . . . ... : ...: . : :.. : : : : .. .
CCDS13 SIENHIRLAVVKVVVLGDKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYDAAILF
310 320 330 340 350 360
180 190 200 210 220 230
pF1KE6 TRFDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAP
:: :: . .. :....: ::: :: . :: :. . :.:::::: .:: :: .
CCDS13 TREDL-CGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSHDDSK
370 380 390 400 410 420
240 250 260 270 280 290
pF1KE6 GS----GCGPSGHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAG
: . ..:.: .. :. :: :. . .:. :.. :. : :: : :
CCDS13 FCEETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLPRKQI--LG
430 440 450 460 470 480
300 310 320 330 340 350
pF1KE6 HPPDAQPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPL
:. :: :.:..:: ..:::. .: .:.: : : . : : .:
CCDS13 --PEELPGQTYDATQQCNLTFGPEYSVCP----GMDVCARLWCAVVRQGQMVCLTKKLPA
490 500 510 520 530
360 370 380 390 400 410
pF1KE6 LDGTECGVEKWCSKGRCRSLVELTPIA-AVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNN
..:: :: . : .:.: . .. . . :: :.::: . ::::::::: :.:::
CCDS13 VEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNN
540 550 560 570 580 590
420 430 440 450 460 470
pF1KE6 PRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAA
: : .:: :.: . :. . : . : .:: .: .. : .: .:
CCDS13 PAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGYQ-SDAKGVKTFVEW---
600 610 620 630 640 650
480 490 500 510 520 530
pF1KE6 VPHSQG---DALCRHMCRAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTF
::. : .:. ::: : .. . . . :::.: : .. :.:: :.:
CCDS13 VPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTEC-----RLYSN-SVCVRGKCVRT
660 670 680 690 700
540 550 560 570 580
pF1KE6 GCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYI----A
:::: . :. .:.: :::::::.:. :.:. ... :. . . . : . . :
CCDS13 GCDGIIGSKLQYDKCGVCGGDNSSCTKIVGTFNK-KSKGYTDVVRIPEGATHIKVRQFKA
710 720 730 740 750 760
590 600 610 620 630 640
pF1KE6 NHRPLFT-HLAVRI-GGRYVVAGKMSISPNTTYPSLLEDGRVEYRVALT--EDRLPRL--
. . :: .::.. .:.:.. ::. :: . : .. .: : . . .: : .
CCDS13 KDQTRFTAYLALKKKNGEYLINGKYMISTSETIIDI--NGTVMNYSGWSHRDDFLHGMGY
770 780 790 800 810 820
650 660 670 680 690
pF1KE6 ---EEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPKPR-----QAWVWAAVR
.:: : : : . ::. . . : .. . . . . . : :
CCDS13 SATKEILIVQILATDPTKPLDVRYSFFVPKKSTPKVNSVTSHGSNKVGSHTSQPQW--VT
830 840 850 860 870 880
700 710 720 730 740
pF1KE6 GP---CSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPCPPYWAVG
:: :: .: .: . . .: : :: :.. : ::.: :. . :.:. :
CCDS13 GPWLACSRTCDTGWHTRTVQCQDGNRK-LAKG--CPLSQRPSAFKQ-CLLKKC
890 900 910 920 930
750 760 770 780 790 800
pF1KE6 DFGPCSASCGGGLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWE
>>CCDS7306.1 ADAMTS14 gene_id:140766|Hs108|chr10 (1223 aa)
initn: 941 init1: 298 opt: 979 Z-score: 820.5 bits: 164.1 E(32554): 2.2e-39
Smith-Waterman score: 1301; 29.5% identity (55.2% similar) in 892 aa overlap (70-933:248-1089)
40 50 60 70 80 90
pF1KE6 ALEPQAVSSYLSPGAPLKGRPPSPGFQRQRQRQRR-AAGGILHLELLVAVGPDVFQAH-Q
.:.:: : : .:.:..: .: . : .
CCDS73 EPDGDLHNEAFGLGDLPNLLGLVGDQLGDTERKRRHAKPGSYSIEVLLVVDDSVVRFHGK
220 230 240 250 260 270
100 110 120 130 140 150
pF1KE6 EDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILTEPEGAPNIT-ANLTSSLLSVCG
: .. :::: .:: :. .: :::... . ::..... .. : .: . :: .::
CCDS73 EHVQNYVLTLMNIVDEIYHDESLGVHINIALVRLIMVGYRQSLSLIERGNPSRSLEQVCR
280 290 300 310 320 330
160 170 180 190 200 210
pF1KE6 WSQTINPEDDTDPGHADLVLYITRFDLELPDGNRQVRGVTQLGGACSPTWSCLITEDTGF
:... . .: . : : :...:: :. :.: : :. : : :: .... ::
CCDS73 WAHSQQRQDPSHAEHHDHVVFLTRQDFG-PSGYAPVTGM------CHPLRSCALNHEDGF
340 350 360 370 380 390
220 230 240 250 260 270
pF1KE6 DLGVTIAHEIGHSFGLEHDGAPGSGCGPS---GHVMASDGAAPRAGLAWSPCSRRQLLSL
. . .:::: :: .:.:::: :.::. : ::: : . :: ::. .:
CCDS73 SSAFVIAHETGHVLGMEHDGQ-GNGCADETSLGSVMAPLVQAAFHRFHWSRCSKLELSRY
400 410 420 430 440
280 290 300 310 320 330
pF1KE6 LSAGRARCVWDPPRPQPGSAGHPPDAQPGLYYSANEQCRVAFGPKAVACTFAREHLDMCQ
: . :. : : .: . .::. ::. :: .:::: :: .: .: . .. :.
CCDS73 LPS--YDCLLDDPF-DP-AWPQPPEL-PGINYSMDEQCRFDFGSGYQTC-LAFRTFEPCK
450 460 470 480 490 500
340 350 360 370 380 390
pF1KE6 ALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRCRSLVELTPIAAV--HGRWSSWG
: : . : . :. : ::::::. ::: ::.: . .: . : ::::
CCDS73 QLWC-SHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHC---IWKSPEQTYGQDGGWSSWT
510 520 530 540 550
400 410 420 430 440 450
pF1KE6 PRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQCA
. ::::::::: .: :.:::: ::.::: :.: .. ..::.. : : .: .::::
CCDS73 KFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEECPGTYEDFRAQQCA
560 570 580 590 600 610
460 470 480 490 500
pF1KE6 RTDGQPLRSSPGGASFYHWGAAVPHSQGDAL--CRHMCRAIGESFIMKRGDSFLDGTRCM
. .. .... . : ::. : :. .:.. . .. .. :::::
CCDS73 KRNSYYVHQNAK----HSW---VPYEPDDDAQKCELICQSADTGDVVFMNQVVHDGTRCS
620 630 640 650 660 670
510 520 530 540 550 560
pF1KE6 PSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSPRKGSF-TAGRAR
: :.:. : : ::: .. :... :.: ::::::: : ::.. :..
CCDS73 YRDPY-----SVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASKQA
680 690 700 710 720
570 580 590 600 610 620
pF1KE6 EYVTFLTVTPNLTSVYIANHRPLFTHLAVR--IGGRYVVAGKMSISPNTTYPSL---LED
. .. . . . : . ...:. . : ... : . . . :. .. ::
CCDS73 GALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGKEATSRTFTAMGLEWED
730 740 750 760 770 780
630 640 650 660 670 680
pF1KE6 GRVEYRVAL-TEDRLPRLEEIRIWGPLQEDADIQVYRRYGEEYGNLTRPDITFTYFQPKP
. . . .: : ::. : : . .. .: . : : : . .
CCDS73 AVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLL--PLIGSNNVLLEE
790 800 810 820 830 840
690 700 710 720 730 740
pF1KE6 RQAWVWAAVR-GPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEP
... :: .::: .::.:.....:.: . ...:. :. ...: . : .:
CCDS73 MDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQHP
850 860 870 880 890 900
750 760 770 780 790
pF1KE6 CP-PYWAVGDFGPCSASCGG-GLRERPVRCVEAQGSLLKTLPPARCRAGAQQPAVALETC
: : :.. ..: :: ::: :.. : ..:. .. . . ::. :: ..: : . :
CCDS73 CSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAG-DRPE-ARRPC
910 920 930 940 950 960
800 810 820 830 840 850
pF1KE6 NPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGLEAPVTEGPGSVDEKLPAPEPC
::::.:... :.:... : :. .. .: .:..: . : .: . :
CCDS73 LRVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTV-------QVC
970 980 990 1000 1010
860 870 880 890 900 910
pF1KE6 VGMSCPPGWGHLDATSAGE--KAPSPWGSIRTGAQAAHVWT------PAAGSCSVSCGRG
.: : .: ..: .. . .: :. .. : . : .:. :: :
CCDS73 SLPAC--GGNHQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQ--
1020 1030 1040 1050 1060 1070
920 930 940 950 960 970
pF1KE6 LMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPCPARWQYKLAACSVSCGRGVV
::. .: .: ..::
CCDS73 -MEV----LDRYCSIPGYHRLCCVSCIKKASGPNPGPDPGPTSLPPFSTPGSPLPGPQDP
1080 1090 1100 1110 1120
>>CCDS31778.2 ADAMTS20 gene_id:80070|Hs108|chr12 (1910 aa)
initn: 981 init1: 384 opt: 937 Z-score: 783.1 bits: 157.9 E(32554): 2.7e-37
Smith-Waterman score: 1640; 27.0% identity (52.4% similar) in 1321 aa overlap (46-1325:232-1433)
20 30 40 50 60 70
pF1KE6 AGILACGFLLGCWGPSHFQQSCLQALEPQAVSSYLSPGAPLKGRPPSPGFQRQRQRQRRA
: .. : ..::: .:...:..:
CCDS31 SVSESQIKETSLPFHTYSNMNEDLNVMKERVLGHTSKNVPLKD-------ERRHSRKKRL
210 220 230 240 250
80 90 100 110 120 130
pF1KE6 AGGILHLELLVAVGPDVFQAHQEDTERYVLTNLNIGAELLRDPSLGAQFRVHLVKMVILT
. ..:..:.. : .:: . . :.:: ..: : . .:::.: ... .::.:..
CCDS31 ISYPRYIEIMVTADAKVVSAHGSNLQNYILTLMSIVATIYKDPSIGNLIHIVVVKLVMIH
260 270 280 290 300 310
140 150 160 170 180 190
pF1KE6 EPEGAPNITANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLELPDGNRQVRGV
. : .: :. . ...: . :.:.:: : ::. :.: : .. ::: :. . .. :.
CCDS31 REEEGPVINFDGATTLKNFCSWQQTQNDLDDVHPSHHDTAVLITREDICSSKEKCNMLGL
320 330 340 350 360 370
200 210 220 230 240 250
pF1KE6 TQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGP----SGHVMAS
. :: :.: ::.:.:. :. . :::::.::..:..:: : : . ::::
CCDS31 SYLGTICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHDDNP--RCKEMKVTKYHVMAP
380 390 400 410 420 430
260 270 280 290 300 310
pF1KE6 DGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQPGLYYSANEQC
. . .:: :::. . .:..: ..:. : : . . :. :: :..:.::
CCDS31 ALSFHMSPWSWSNCSRKYVTEFLDTGYGECLLDKPDEE---IYNLPSELPGSRYDGNKQC
440 450 460 470 480
320 330 340 350 360 370
pF1KE6 RVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCSKGRC
..:::: . : :...:. : : . ...: :: :::.:: : .: :
CCDS31 ELAFGPGSQMCP----HINICMHLWCTSTEKLHKGCFTQHVPPADGTDCGPGMHCRHGLC
490 500 510 520 530 540
380 390 400 410 420 430
pF1KE6 RSLVELTPIAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGADLQAE
. . : :.:.:. : : : :::.::::. . :.:: :.: :: ::: .. .
CCDS31 VN--KETETRPVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFR
550 560 570 580 590 600
440 450 460 470 480
pF1KE6 MCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDAL---CRHMCR
:::..: : .: .::. .:. : : : : .: .:. .: . :. .:.
CCDS31 SCNTDSCPKGTQDFREKQCSDFNGKHLDIS-GIPSNVRW---LPRYSGIGTKDRCKLYCQ
610 620 630 640 650
490 500 510 520 530 540
pF1KE6 AIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVC
. : .... : ::: : : . : ..::.:.: . ::: ..:. :.: ::
CCDS31 VAGTNYFYLLKDMVEDGTPC---GTE---THDICVQGQCMAAGCDHVLNSSAKIDKCGVC
660 670 680 690 700 710
550 560 570 580 590 600
pF1KE6 GGDNSTCSPRKGSFTAGRAREYVTFLTVTPNLTSVYIANH----RPLFTHLAVRIG-GRY
:::::.:. : :.... : . . . . :.: : .. .: ..::. . : .
CCDS31 GGDNSSCKTITGVFNSSH-YGYNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAEGNF
720 730 740 750 760 770
610 620 630 640 650 660
pF1KE6 VVAGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQVYRRYGE
. :.. .: . .. . :. . . ... . :.. . ... .::
CCDS31 LFNGNFLLSTSKKEINV-QGTRTVIEYSGSNNAVERINST---NRQEKELILQVL-----
780 790 800 810 820
670 680 690 700 710
pF1KE6 EYGNLTRPDITFTYFQPKPRQA--WVWAAVRGP---CSVSCGAGLRWVNYSCLDQARKEL
::: ::. ... : ... ..: :: :. : ::. : .:. .. . .
CCDS31 CVGNLYNPDVHYSFNIPLEERSDMFTWDPY-GPWEGCTKMC-QGLQRRNITCIHKSDHSV
830 840 850 860 870 880
720 730 740 750 760 770
pF1KE6 VETVQCQGSQQPPAWPEACVLEPCPPYWAVGDFGPCSASCGGGLRERPVRCVEAQGSLLK
: .:. : ..: . : : : . ::..:: : : ..:.. . .
CCDS31 VSDKECDHLPLPSFVTQSCNTD-CELRWHVIGKSECSSQCGQGYRTLDIHCMKYSIHEGQ
890 900 910 920 930 940
780 790 800 810 820 830
pF1KE6 TLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPSSCTSAGGAGLALENETCVPGADGL
:. : : . : :. . .::. :: :.:. . :.: .. :. ...
CCDS31 TVQVDDHYCGDQLKPPTQELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESYCM---NNF
950 960 970 980 990
840 850 860 870 880 890
pF1KE6 EAPVTEGPGSVDEKLPAPEPCVGMSCPPGWGHLDATSAGEKAPSPWGSIRTGAQAAHVWT
.... . .. : : .::: .: : : :.
CCDS31 GHRLADNECQELSRVTR-ENCNEFSCP-SW-----------AASEWSE------------
1000 1010 1020 1030
900 910 920 930 940 950
pF1KE6 PAAGSCSVSCGRGLMELRFLCMDSALRVP-VQEELCGLASKPGSRREVCQAVPCPARWQY
: :.::.: . . :. : : ... .:. ..:: : :. : : ::
CCDS31 -----CLVTCGKGTKQRQVWCQ---LNVDHLSDGFCNSSTKPESLSP-CELHTC-ASWQV
1040 1050 1060 1070 1080
960 970 980 990 1000 1010
pF1KE6 -KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCP---
. :...::.: : . :. .. . .: ::.:. :: ...: : ::
CCDS31 GPWGPCTTTCGHGYQMRDVKCV----NELASAVLEDTECHEASRPSDRQSCVLTPCSFIS
1090 1100 1110 1120 1130
1020 1030 1040 1050
pF1KE6 -------P--------RWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAAL
: .:. : :::.::: :: : :.: .. : .::. :: :
CCDS31 KLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSC---RDALDRIADESYCAHL
1140 1150 1160 1170 1180 1190
1060 1070 1080 1090 1100 1110
pF1KE6 VRPEASVPCLIADCTYRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPK
:: :. . : .:..: : ::.::: : :. :. . . :. ..:. .
CCDS31 PRPAEIWDCF-TPCG-EWQAGDWSPCSASCGHGKTTRQVLCM--NYHQPIDENYCDPEVR
1200 1210 1220 1230 1240 1250
1120 1130 1140 1150 1160 1170
pF1KE6 PVTVRGCWAGPCVGQGTPSLVPHEEAAAPGR--TTATPAGASLEWSQARGLLFSPAPQPR
:. . : . : . : : . :. .: : .:: .. . . :. .
CCDS31 PLMEQECSLAAC--PPAHSHFPSSPVQ-PSYYLSTNLPLTQKLEDNENQ--VVHPSVRGN
1260 1270 1280 1290 1300
1180 1190 1200 1210 1220 1230
pF1KE6 RLLPGPQENSVQSSACGRQHLEPTGTIDMRGPGQADCAVAIGRPLGEVVTLRVLESSLNC
. :: . .: . : :: . . : : . . : .: : :. .:
CCDS31 QWRTGPWGSCSSSCSGGLQH-RAVVCQDENGQSASYCDAASKPP-----ELQ------QC
1310 1320 1330 1340 1350
1240 1250 1260 1270 1280 1290
pF1KE6 SAGDMLLLWGRLTWRKMCRKLLDMTFSSKTNTLVVRQRCGRPGGGVLLRYGSQLA--PET
. : :. .: . : . ..:. ::. : :.: .: .. ... : .
CCDS31 GPGPCPQ-WNYGNWGE-CSQTCGGGIKSR---LVI---CQFPNGQILEDHNCEIVNKPPS
1360 1370 1380 1390 1400
1300 1310 1320 1330 1340 1350
pF1KE6 FYRECDMQLFGPWGEIVSPSLSPATSNAGGCRLFINVAPHARIAIHALATNMGAGTEGAN
.: :. : :: : :: ...:
CCDS31 VI-QCHMHAC-PAD--VSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDTNCSQVQK
1410 1420 1430 1440 1450 1460
1360 1370 1380 1390 1400 1410
pF1KE6 ASYILIRDTHSLRTTAFHGQQVLYWESESSQAEMEFSEGFLKAQASLRGQYWTLQSWVPE
CCDS31 PPTHKACRSVRCPSWKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEEMCDQSTRPCSQ
1470 1480 1490 1500 1510 1520
1427 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 15:55:36 2016 done: Tue Nov 8 15:55:37 2016
Total Scan time: 4.420 Total Display time: 0.410
Function used was FASTA [36.3.4 Apr, 2011]