Result of FASTA (omim) for
pFN21AE6730
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6730, 809 aa
1>>>pF1KE6730 809 - 809 aa - 809 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.1102+/-0.000422; mu= -9.7560+/- 0.026
mean_var=439.6571+/-91.333, 0's: 0 Z-trim(123.4): 103 B-trim: 806 in 1/60
Lambda= 0.061167
statistics sampled from 42988 (43106) to 42988 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.789), E-opt: 0.2 (0.505), width: 16
Scan time: 11.480
The best scores are: opt bits E(85289)
NP_001107572 (OMIM: 616667) seizure 6-like protein ( 809) 5675 515.6 3.4e-145
XP_016878624 (OMIM: 616667) PREDICTED: seizure 6-l ( 739) 4721 431.4 6.9e-120
NP_036542 (OMIM: 616667) seizure 6-like protein 2 ( 853) 4525 414.2 1.2e-114
NP_001230262 (OMIM: 616667) seizure 6-like protein ( 879) 4525 414.2 1.3e-114
NP_001230261 (OMIM: 616667) seizure 6-like protein ( 923) 4525 414.2 1.3e-114
NP_001107571 (OMIM: 616667) seizure 6-like protein ( 840) 3941 362.6 4e-99
NP_963869 (OMIM: 616667) seizure 6-like protein 2 ( 910) 3941 362.7 4.2e-99
XP_005255309 (OMIM: 616667) PREDICTED: seizure 6-l ( 859) 3473 321.3 1.1e-86
NP_001092105 (OMIM: 616666) seizure protein 6 homo ( 993) 2401 226.8 3.7e-58
NP_001277131 (OMIM: 616666) seizure protein 6 homo ( 869) 2352 222.4 6.6e-57
NP_849191 (OMIM: 616666) seizure protein 6 homolog ( 994) 2352 222.5 7.3e-57
NP_066938 (OMIM: 607021) seizure 6-like protein is (1024) 2347 222.0 1e-56
NP_001171702 (OMIM: 607021) seizure 6-like protein (1023) 2343 221.7 1.3e-56
XP_006724258 (OMIM: 607021) PREDICTED: seizure 6-l (1022) 2335 221.0 2.1e-56
XP_011522619 (OMIM: 616666) PREDICTED: seizure pro ( 964) 2271 215.3 1e-54
XP_011522617 (OMIM: 616666) PREDICTED: seizure pro (1073) 2269 215.2 1.2e-54
NP_001171703 (OMIM: 607021) seizure 6-like protein (1013) 2128 202.7 6.6e-51
NP_001171704 (OMIM: 607021) seizure 6-like protein (1011) 2123 202.3 9e-51
XP_005261496 (OMIM: 607021) PREDICTED: seizure 6-l (1012) 2118 201.8 1.2e-50
NP_001171706 (OMIM: 607021) seizure 6-like protein ( 948) 1847 177.9 1.8e-43
XP_011528341 (OMIM: 607021) PREDICTED: seizure 6-l ( 957) 1844 177.6 2.2e-43
XP_011528340 (OMIM: 607021) PREDICTED: seizure 6-l ( 958) 1844 177.6 2.2e-43
XP_011528339 (OMIM: 607021) PREDICTED: seizure 6-l ( 959) 1844 177.6 2.2e-43
XP_016884189 (OMIM: 607021) PREDICTED: seizure 6-l ( 958) 1661 161.5 1.6e-38
XP_016884188 (OMIM: 607021) PREDICTED: seizure 6-l ( 959) 1661 161.5 1.6e-38
XP_005261497 (OMIM: 607021) PREDICTED: seizure 6-l ( 960) 1661 161.5 1.6e-38
NP_001171705 (OMIM: 607021) seizure 6-like protein ( 949) 1660 161.4 1.7e-38
XP_011533056 (OMIM: 608397) PREDICTED: CUB and sus (2238) 748 81.2 5.4e-14
XP_011515117 (OMIM: 608399) PREDICTED: CUB and sus (2173) 687 75.8 2.2e-12
XP_011533055 (OMIM: 608397) PREDICTED: CUB and sus (2595) 655 73.1 1.8e-11
XP_016869220 (OMIM: 608397) PREDICTED: CUB and sus (3327) 655 73.2 2.2e-11
XP_011533054 (OMIM: 608397) PREDICTED: CUB and sus (3549) 655 73.2 2.3e-11
NP_150094 (OMIM: 608397) CUB and sushi domain-cont (3564) 655 73.2 2.3e-11
XP_016855682 (OMIM: 608398) PREDICTED: CUB and sus (2294) 648 72.4 2.5e-11
XP_016855681 (OMIM: 608398) PREDICTED: CUB and sus (2315) 648 72.4 2.5e-11
XP_016855680 (OMIM: 608398) PREDICTED: CUB and sus (2973) 648 72.5 3e-11
XP_016855679 (OMIM: 608398) PREDICTED: CUB and sus (3362) 648 72.6 3.3e-11
NP_443128 (OMIM: 608398) CUB and sushi domain-cont (3487) 648 72.6 3.4e-11
XP_016855678 (OMIM: 608398) PREDICTED: CUB and sus (3506) 648 72.6 3.4e-11
XP_016855683 (OMIM: 608398) PREDICTED: CUB and sus (3566) 648 72.6 3.5e-11
XP_016855677 (OMIM: 608398) PREDICTED: CUB and sus (3567) 648 72.6 3.5e-11
XP_016855676 (OMIM: 608398) PREDICTED: CUB and sus (3606) 648 72.6 3.5e-11
XP_016855675 (OMIM: 608398) PREDICTED: CUB and sus (3607) 648 72.6 3.5e-11
XP_016855674 (OMIM: 608398) PREDICTED: CUB and sus (3607) 648 72.6 3.5e-11
NP_001268885 (OMIM: 608398) CUB and sushi domain-c (3631) 648 72.6 3.5e-11
XP_016868500 (OMIM: 608399) PREDICTED: CUB and sus (3507) 509 60.3 1.7e-07
XP_016868498 (OMIM: 608399) PREDICTED: CUB and sus (3637) 509 60.3 1.7e-07
XP_016868501 (OMIM: 608399) PREDICTED: CUB and sus (3463) 506 60.0 2e-07
NP_443132 (OMIM: 608399) CUB and sushi domain-cont (3538) 506 60.0 2.1e-07
XP_016868499 (OMIM: 608399) PREDICTED: CUB and sus (3577) 506 60.1 2.1e-07
>>NP_001107572 (OMIM: 616667) seizure 6-like protein 2 i (809 aa)
initn: 5675 init1: 5675 opt: 5675 Z-score: 2727.8 bits: 515.6 E(85289): 3.4e-145
Smith-Waterman score: 5675; 99.9% identity (99.9% similar) in 809 aa overlap (1-809:1-809)
10 20 30 40 50 60
pF1KE6 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 RRGPEMGYLPGSDPDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP
::::::::::::: ::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 ELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPAYLLSCGFPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPAYLLSCGFPP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 RPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 NATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 PVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 TTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 AGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 QLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGW
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE6 RTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE6 HRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNP
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE6 GVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAYEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAYEE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE6 LLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGS
730 740 750 760 770 780
790 800
pF1KE6 HSYSPITVESDFSNPLYEAGDTREYEVSI
:::::::::::::::::::::::::::::
NP_001 HSYSPITVESDFSNPLYEAGDTREYEVSI
790 800
>>XP_016878624 (OMIM: 616667) PREDICTED: seizure 6-like (739 aa)
initn: 4721 init1: 4721 opt: 4721 Z-score: 2273.3 bits: 431.4 E(85289): 6.9e-120
Smith-Waterman score: 5048; 91.3% identity (91.3% similar) in 809 aa overlap (1-809:1-739)
10 20 30 40 50 60
pF1KE6 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 RRGPEMGYLPGSDPDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP
:::::::::::
XP_016 RRGPEMGYLPG-------------------------------------------------
70
130 140 150 160 170 180
pF1KE6 ELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPAYLLSCGFPP
:::::::::::::::::::::::::::::::::::::::
XP_016 ---------------------PPLGPEGGEEETTTTIITTTTVTTTVTSPAYLLSCGFPP
80 90 100 110
190 200 210 220 230 240
pF1KE6 RPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIH
120 130 140 150 160 170
250 260 270 280 290 300
pF1KE6 NATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLS
180 190 200 210 220 230
310 320 330 340 350 360
pF1KE6 PVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNV
240 250 260 270 280 290
370 380 390 400 410 420
pF1KE6 TTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEP
300 310 320 330 340 350
430 440 450 460 470 480
pF1KE6 AGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLA
360 370 380 390 400 410
490 500 510 520 530 540
pF1KE6 QLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGW
420 430 440 450 460 470
550 560 570 580 590 600
pF1KE6 RTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANG
480 490 500 510 520 530
610 620 630 640 650 660
pF1KE6 HRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNP
540 550 560 570 580 590
670 680 690 700 710 720
pF1KE6 GVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAYEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAYEE
600 610 620 630 640 650
730 740 750 760 770 780
pF1KE6 LLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGS
660 670 680 690 700 710
790 800
pF1KE6 HSYSPITVESDFSNPLYEAGDTREYEVSI
:::::::::::::::::::::::::::::
XP_016 HSYSPITVESDFSNPLYEAGDTREYEVSI
720 730
>>NP_036542 (OMIM: 616667) seizure 6-like protein 2 isof (853 aa)
initn: 5009 init1: 4525 opt: 4525 Z-score: 2179.0 bits: 414.2 E(85289): 1.2e-114
Smith-Waterman score: 4837; 85.1% identity (88.3% similar) in 848 aa overlap (13-809:13-853)
10 20 30 40 50 60
pF1KE6 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL
::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL
10 20 30 40 50 60
70 80 90 100 110
pF1KE6 RRGPEMGYLPGSDPDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGV-RGAGPT-
::::::::::: : :. : .:. .. .. .: : . .. :.. .: : .
NP_036 RRGPEMGYLPG----PPLG-PEGGEEETTTTIITTTTVTTTVTSPVLCNNNISEGEGYVE
70 80 90 100 110
120 130 140
pF1KE6 APELLTPP----------------PGTTAPPPPSP------------ASPGPP-LGPEG-
.:.: .: :: . :. : : :.:.
NP_036 SPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGLAPRLL
120 130 140 150 160 170
150 160 170 180
pF1KE6 ------GEEETTTTIITTTTVTTTVTSP-------------AYLLSCGFPPRPAHGDVSV
:: .. . :. . :: :::::::::::::::::::
NP_036 ANSSMLGEGQVLRS--PTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGFPPRPAHGDVSV
180 190 200 210 220 230
190 200 210 220 230 240
pF1KE6 TDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 TDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVS
240 250 260 270 280 290
250 260 270 280 290 300
pF1KE6 PEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDSDMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 PEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDSDMD
300 310 320 330 340 350
310 320 330 340 350 360
pF1KE6 DVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 DVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRP
360 370 380 390 400 410
370 380 390 400 410 420
pF1KE6 GALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 GALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDW
420 430 440 450 460 470
430 440 450 460 470 480
pF1KE6 PQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 PQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRR
480 490 500 510 520 530
490 500 510 520 530 540
pF1KE6 RLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 RLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLI
540 550 560 570 580 590
550 560 570 580 590 600
pF1KE6 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGF
600 610 620 630 640 650
610 620 630 640 650 660
pF1KE6 PVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 PVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQT
660 670 680 690 700 710
670 680 690 700 710 720
pF1KE6 LYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAYEELLDNRKLEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 LYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAYEELLDNRKLEV
720 730 740 750 760 770
730 740 750 760 770 780
pF1KE6 TQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 TQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVE
780 790 800 810 820 830
790 800
pF1KE6 SDFSNPLYEAGDTREYEVSI
::::::::::::::::::::
NP_036 SDFSNPLYEAGDTREYEVSI
840 850
>>NP_001230262 (OMIM: 616667) seizure 6-like protein 2 i (879 aa)
initn: 5177 init1: 4525 opt: 4525 Z-score: 2178.9 bits: 414.2 E(85289): 1.3e-114
Smith-Waterman score: 4874; 86.4% identity (86.4% similar) in 841 aa overlap (83-809:39-879)
60 70 80 90 100 110
pF1KE6 ELLHGALLRRGPEMGYLPGSDPDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGV
::::::::::::::::::::::::::::::
NP_001 PPPPQLLFLILLSCPWIQGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGV
10 20 30 40 50 60
120 130 140 150 160 170
pF1KE6 RGAGPTAPELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSP--
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGAGPTAPELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPVL
70 80 90 100 110 120
pF1KE6 ------------------------------------------------------------
NP_001 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL
130 140 150 160 170 180
pF1KE6 ----------------------------------------------------AYLLSCGF
::::::::
NP_001 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGF
190 200 210 220 230 240
180 190 200 210 220 230
pF1KE6 PPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGT
250 260 270 280 290 300
240 250 260 270 280 290
pF1KE6 IHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSP
310 320 330 340 350 360
300 310 320 330 340 350
pF1KE6 LSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHG
370 380 390 400 410 420
360 370 380 390 400 410
pF1KE6 NVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELS
430 440 450 460 470 480
420 430 440 450 460 470
pF1KE6 EPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARV
490 500 510 520 530 540
480 490 500 510 520 530
pF1KE6 LAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEW
550 560 570 580 590 600
540 550 560 570 580 590
pF1KE6 GWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIA
610 620 630 640 650 660
600 610 620 630 640 650
pF1KE6 NGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCL
670 680 690 700 710 720
660 670 680 690 700 710
pF1KE6 NPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAY
730 740 750 760 770 780
720 730 740 750 760 770
pF1KE6 EELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFS
790 800 810 820 830 840
780 790 800
pF1KE6 GSHSYSPITVESDFSNPLYEAGDTREYEVSI
:::::::::::::::::::::::::::::::
NP_001 GSHSYSPITVESDFSNPLYEAGDTREYEVSI
850 860 870
>>NP_001230261 (OMIM: 616667) seizure 6-like protein 2 i (923 aa)
initn: 5661 init1: 4525 opt: 4525 Z-score: 2178.6 bits: 414.2 E(85289): 1.3e-114
Smith-Waterman score: 4874; 86.4% identity (86.4% similar) in 841 aa overlap (83-809:83-923)
60 70 80 90 100 110
pF1KE6 ELLHGALLRRGPEMGYLPGSDPDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGV
::::::::::::::::::::::::::::::
NP_001 ELLHGALLRRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGV
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE6 RGAGPTAPELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSP--
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGAGPTAPELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPVL
120 130 140 150 160 170
pF1KE6 ------------------------------------------------------------
NP_001 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL
180 190 200 210 220 230
pF1KE6 ----------------------------------------------------AYLLSCGF
::::::::
NP_001 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGF
240 250 260 270 280 290
180 190 200 210 220 230
pF1KE6 PPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGT
300 310 320 330 340 350
240 250 260 270 280 290
pF1KE6 IHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSP
360 370 380 390 400 410
300 310 320 330 340 350
pF1KE6 LSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHG
420 430 440 450 460 470
360 370 380 390 400 410
pF1KE6 NVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELS
480 490 500 510 520 530
420 430 440 450 460 470
pF1KE6 EPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARV
540 550 560 570 580 590
480 490 500 510 520 530
pF1KE6 LAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEW
600 610 620 630 640 650
540 550 560 570 580 590
pF1KE6 GWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIA
660 670 680 690 700 710
600 610 620 630 640 650
pF1KE6 NGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCL
720 730 740 750 760 770
660 670 680 690 700 710
pF1KE6 NPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAY
780 790 800 810 820 830
720 730 740 750 760 770
pF1KE6 EELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFS
840 850 860 870 880 890
780 790 800
pF1KE6 GSHSYSPITVESDFSNPLYEAGDTREYEVSI
:::::::::::::::::::::::::::::::
NP_001 GSHSYSPITVESDFSNPLYEAGDTREYEVSI
900 910 920
>--
initn: 563 init1: 563 opt: 563 Z-score: 289.0 bits: 64.6 E(85289): 2.3e-09
Smith-Waterman score: 563; 98.8% identity (98.8% similar) in 82 aa overlap (1-82:1-82)
10 20 30 40 50 60
pF1KE6 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 RRGPEMGYLPGSDPDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP
::::::::::::: ::::::::
NP_001 RRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP
70 80 90 100 110 120
>>NP_001107571 (OMIM: 616667) seizure 6-like protein 2 i (840 aa)
initn: 4421 init1: 3937 opt: 3941 Z-score: 1900.6 bits: 362.6 E(85289): 4e-99
Smith-Waterman score: 4722; 83.6% identity (86.8% similar) in 848 aa overlap (13-809:13-840)
10 20 30 40 50 60
pF1KE6 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL
10 20 30 40 50 60
70 80 90 100 110
pF1KE6 RRGPEMGYLPGSDPDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGV-RGAGPT-
::::::::::: : :. : .:. .. .. .: : . .. :.. .: : .
NP_001 RRGPEMGYLPG----PPLG-PEGGEEETTTTIITTTTVTTTVTSPVLCNNNISEGEGYVE
70 80 90 100 110
120 130 140
pF1KE6 APELLTPP----------------PGTTAPPPPSP------------ASPGPP-LGPEG-
.:.: .: :: . :. : : :.:.
NP_001 SPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVLAGGGSPGLAPRLL
120 130 140 150 160 170
150 160 170 180
pF1KE6 ------GEEETTTTIITTTTVTTTVTSP-------------AYLLSCGFPPRPAHGDVSV
:: .. . :. . :: :::::::::::::::::::
NP_001 ANSSMLGEGQVLRS--PTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGFPPRPAHGDVSV
180 190 200 210 220 230
190 200 210 220 230 240
pF1KE6 TDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVS
240 250 260 270 280 290
250 260 270 280 290 300
pF1KE6 PEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDSDMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDSDMD
300 310 320 330 340 350
310 320 330 340 350 360
pF1KE6 DVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRP
360 370 380 390 400 410
370 380 390 400 410 420
pF1KE6 GALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDW
420 430 440 450 460 470
430 440 450 460 470 480
pF1KE6 PQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRR
480 490 500 510 520 530
490 500 510 520 530 540
pF1KE6 RLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLI
540 550 560 570 580 590
550 560 570 580 590 600
pF1KE6 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGF
600 610 620 630 640 650
610 620 630 640 650 660
pF1KE6 PVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCLNPGVPENGYQT
660 670 680 690 700 710
670 680 690 700 710 720
pF1KE6 LYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAYEELLDNRKLEV
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKV-------------
720 730 740 750 760
730 740 750 760 770 780
pF1KE6 TQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHSYSPITVE
770 780 790 800 810 820
790 800
pF1KE6 SDFSNPLYEAGDTREYEVSI
::::::::::::::::::::
NP_001 SDFSNPLYEAGDTREYEVSI
830 840
>>NP_963869 (OMIM: 616667) seizure 6-like protein 2 isof (910 aa)
initn: 5073 init1: 3937 opt: 3941 Z-score: 1900.2 bits: 362.7 E(85289): 4.2e-99
Smith-Waterman score: 4759; 84.9% identity (84.9% similar) in 841 aa overlap (83-809:83-910)
60 70 80 90 100 110
pF1KE6 ELLHGALLRRGPEMGYLPGSDPDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGV
::::::::::::::::::::::::::::::
NP_963 ELLHGALLRRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGV
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE6 RGAGPTAPELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSP--
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 RGAGPTAPELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPVL
120 130 140 150 160 170
pF1KE6 ------------------------------------------------------------
NP_963 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL
180 190 200 210 220 230
pF1KE6 ----------------------------------------------------AYLLSCGF
::::::::
NP_963 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGF
240 250 260 270 280 290
180 190 200 210 220 230
pF1KE6 PPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 PPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGT
300 310 320 330 340 350
240 250 260 270 280 290
pF1KE6 IHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 IHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSP
360 370 380 390 400 410
300 310 320 330 340 350
pF1KE6 LSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 LSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHG
420 430 440 450 460 470
360 370 380 390 400 410
pF1KE6 NVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 NVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELS
480 490 500 510 520 530
420 430 440 450 460 470
pF1KE6 EPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 EPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARV
540 550 560 570 580 590
480 490 500 510 520 530
pF1KE6 LAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 LAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEW
600 610 620 630 640 650
540 550 560 570 580 590
pF1KE6 GWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 GWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIA
660 670 680 690 700 710
600 610 620 630 640 650
pF1KE6 NGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 NGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCL
720 730 740 750 760 770
660 670 680 690 700 710
pF1KE6 NPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 NPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKV--
780 790 800 810 820 830
720 730 740 750 760 770
pF1KE6 EELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFS
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 -----------TQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFS
840 850 860 870
780 790 800
pF1KE6 GSHSYSPITVESDFSNPLYEAGDTREYEVSI
:::::::::::::::::::::::::::::::
NP_963 GSHSYSPITVESDFSNPLYEAGDTREYEVSI
880 890 900 910
>--
initn: 563 init1: 563 opt: 563 Z-score: 289.1 bits: 64.6 E(85289): 2.3e-09
Smith-Waterman score: 563; 98.8% identity (98.8% similar) in 82 aa overlap (1-82:1-82)
10 20 30 40 50 60
pF1KE6 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 RRGPEMGYLPGSDPDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP
::::::::::::: ::::::::
NP_963 RRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP
70 80 90 100 110 120
>>XP_005255309 (OMIM: 616667) PREDICTED: seizure 6-like (859 aa)
initn: 4744 init1: 3473 opt: 3473 Z-score: 1677.3 bits: 321.3 E(85289): 1.1e-86
Smith-Waterman score: 4255; 78.7% identity (78.8% similar) in 841 aa overlap (83-809:83-859)
60 70 80 90 100 110
pF1KE6 ELLHGALLRRGPEMGYLPGSDPDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGV
::::::::::::::::::::::::::::::
XP_005 ELLHGALLRRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGV
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE6 RGAGPTAPELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSP--
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGAGPTAPELLTPPPGTTAPPPPSPASPGPPLGPEGGEEETTTTIITTTTVTTTVTSPVL
120 130 140 150 160 170
pF1KE6 ------------------------------------------------------------
XP_005 CNNNISEGEGYVESPDLGSPVSRTLGLLDCTYSIHVYPGYGIEIQVQTLNLSQEEELLVL
180 190 200 210 220 230
pF1KE6 ----------------------------------------------------AYLLSCGF
::::::::
XP_005 AGGGSPGLAPRLLANSSMLGEGQVLRSPTNRLLLHFQSPRVPRGGGFRIHYQAYLLSCGF
240 250 260 270 280 290
180 190 200 210 220 230
pF1KE6 PPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PPRPAHGDVSVTDLHPGGTATFHCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGT
300 310 320 330 340 350
240 250 260 270 280 290
pF1KE6 IHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IHNATLGRIVSPEPGGAVGPNLTCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSP
360 370 380 390 400 410
300 310 320 330 340 350
pF1KE6 LSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSPVIYDSDMDDVPERGLISDAQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHG
420 430 440 450 460 470
360 370 380 390 400 410
pF1KE6 NVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NVTTTDPEYRPGALATFSCLPGYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELS
480 490 500 510 520 530
420 430 440 450 460 470
pF1KE6 EPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EPAGVVLSPDWPQSYSPGQDCVWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARV
540 550 560 570 580 590
480 490 500 510 520 530
pF1KE6 LAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LAQLRGPQPRRRLLSSGPDLTLQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEW
600 610 620 630 640 650
540 550 560 570 580 590
pF1KE6 GWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GWRTASHGDLIRGTVLTYQCEPGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIA
660 670 680 690 700 710
600 610 620 630 640 650
pF1KE6 NGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCALKYEPCL
:::::::::::::::::::::::::::::::::::::::::::::::::::::.
XP_005 NGHRTASDAGFPVGSHVQYRCLPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCAF------
720 730 740 750 760
660 670 680 690 700 710
pF1KE6 NPGVPENGYQTLYKHHYQAGESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVAY
::
XP_005 ----------------------------------------------------------AY
720 730 740 750 760 770
pF1KE6 EELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EELLDNRKLEVTQTTDPSRQLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFS
770 780 790 800 810 820
780 790 800
pF1KE6 GSHSYSPITVESDFSNPLYEAGDTREYEVSI
:::::::::::::::::::::::::::::::
XP_005 GSHSYSPITVESDFSNPLYEAGDTREYEVSI
830 840 850
>--
initn: 563 init1: 563 opt: 563 Z-score: 289.5 bits: 64.5 E(85289): 2.2e-09
Smith-Waterman score: 563; 98.8% identity (98.8% similar) in 82 aa overlap (1-82:1-82)
10 20 30 40 50 60
pF1KE6 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MGTPRAQHPPPPQLLFLILLSCPWIQGLPLKEEEILPEPGSETPTVASEALAELLHGALL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 RRGPEMGYLPGSDPDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP
::::::::::::: ::::::::
XP_005 RRGPEMGYLPGSDRDPTLATPPAGQTLAVPSLPRATEPGTGPLTTAVTPNGVRGAGPTAP
70 80 90 100 110 120
>>NP_001092105 (OMIM: 616666) seizure protein 6 homolog (993 aa)
initn: 2159 init1: 1155 opt: 2401 Z-score: 1165.2 bits: 226.8 E(85289): 3.7e-58
Smith-Waterman score: 2401; 50.2% identity (78.4% similar) in 644 aa overlap (171-809:352-993)
150 160 170 180 190 200
pF1KE6 GPPLGPEGGEEETTTTIITTTTVTTTVTSPAYLLSCGFPPRPAHGDVSVTDLHPGGTATF
:::::: :: :::.:::.::.:::::.: :
NP_001 VIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAYGDVTVTSLHPGGSARF
330 340 350 360 370 380
210 220 230 240 250 260
pF1KE6 HCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEPGGAVGPNL
:: .::::.: . : :::.:.: :... : :.:.:::.:.::: :::::: : . ::
NP_001 HCATGYQLKGARHLTCLNATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNL
390 400 410 420 430 440
270 280 290 300 310
pF1KE6 TCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDS-DMDDVPERGLISD
::.:..:: ::.:::::::.::: ::.:::..:.: . .: .::: ... .: .::.:.
NP_001 TCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSYEVEYLPIEGLLSS
450 460 470 480 490 500
320 330 340 350 360 370
pF1KE6 AQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLP
.. ..::: ... . ..::.:::.. .:. ::. .:: ... : : :. . ::: :
NP_001 GKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSSTPTYPVGTTVEFSCDP
510 520 530 540 550 560
380 390 400 410 420 430
pF1KE6 GYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDC
::.:: . :::::: .:.::.:::::.:.:.::... :::::::.::. :. ::::
NP_001 GYTLEQGS--IIIECVDPHDPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDC
570 580 590 600 610
440 450 460 470 480 490
pF1KE6 VWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLT
.:::::.:.:::.:....: . ::.::..::: .::::.: ::. . .:..: :.:
NP_001 IWGVHVEEDKRIMLDIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSHFKLFTSMADVT
620 630 640 650 660 670
500 510 520 530 540 550
pF1KE6 LQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCE
.:::. :: : ::::.:: :::::::::::: ::.. :. .:..:::.::::
NP_001 IQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQPELVHGTVVTYQCY
680 690 700 710 720 730
560 570 580 590 600 610
pF1KE6 PGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRC
:::...::..: :::::.:: :.::.. .: :::.. ...: :. ::::. ::: :
NP_001 PGYQVVGSSVLMCQWDLTWSEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYIC
740 750 760 770 780 790
620 630 640 650 660 670
pF1KE6 LPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCAL-KYEPCLNPGVPENGYQTLYKHHYQAG
:. : :...:::..:..:.::::::.::: : . .:: . ..:::: .. :. . ::
NP_001 DQGFVLMGSSILTCHDRQAGSPKWSDRAPKCLLEQLKPCHGLSAPENGARSPEKQLHPAG
800 810 820 830 840 850
680 690 700 710 720 730
pF1KE6 ESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVA-YEELLDNRKLEVTQTTDPSR
...: : :. : :...: :::::::.:.. ::.:..: . . ..:.:.:... :
NP_001 ATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAASLDGFYNSRSLDVAKAPAASS
860 870 880 890 900 910
740 750 760 770 780 790
pF1KE6 QLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHS--YSPITVESDFSNP
:.....: ::.::: ...: .:::.:...::::: . . . :. ::.:: :.::
NP_001 TLDAAHIAAAIFLPLVAMVLLVGGVYFYFSRLQGKSSLQLPRPRPRPYNRITIESAFDNP
920 930 940 950 960 970
800
pF1KE6 LYEAGDTREYEVSI
::.:.::::::::
NP_001 TYETGETREYEVSI
980 990
>>NP_001277131 (OMIM: 616666) seizure protein 6 homolog (869 aa)
initn: 2029 init1: 1155 opt: 2352 Z-score: 1142.6 bits: 222.4 E(85289): 6.6e-57
Smith-Waterman score: 2352; 49.6% identity (78.1% similar) in 635 aa overlap (171-800:227-859)
150 160 170 180 190 200
pF1KE6 GPPLGPEGGEEETTTTIITTTTVTTTVTSPAYLLSCGFPPRPAHGDVSVTDLHPGGTATF
:::::: :: :::.:::.::.:::::.: :
NP_001 VIRSPTHQAALRFQSLPPPAGPGTFHFHYQAYLLSCHFPRRPAYGDVTVTSLHPGGSARF
200 210 220 230 240 250
210 220 230 240 250 260
pF1KE6 HCDSGYQLQGEETLICLNGTRPSWNGETPSCMASCGGTIHNATLGRIVSPEPGGAVGPNL
:: .::::.: . : :::.:.: :... : :.:.:::.:.::: :::::: : . ::
NP_001 HCATGYQLKGARHLTCLNATQPFWDSKEPVCIAACGGVIRNATTGRIVSPGFPGNYSNNL
260 270 280 290 300 310
270 280 290 300 310
pF1KE6 TCRWVIEAAEGRRLHLHFERVSLDEDNDRLMVRSGGSPLSPVIYDS-DMDDVPERGLISD
::.:..:: ::.:::::::.::: ::.:::..:.: . .: .::: ... .: .::.:.
NP_001 TCHWLLEAPEGQRLHLHFEKVSLAEDDDRLIIRNGDNVEAPPVYDSYEVEYLPIEGLLSS
320 330 340 350 360 370
320 330 340 350 360 370
pF1KE6 AQSLYVELLSETPANPLLLSLRFEAFEEDRCFAPFLAHGNVTTTDPEYRPGALATFSCLP
.. ..::: ... . ..::.:::.. .:. ::. .:: ... : : :. . ::: :
NP_001 GKHFFVELSTDSSGAAAGMALRYEAFQQGHCYEPFVKYGNFSSSTPTYPVGTTVEFSCDP
380 390 400 410 420 430
380 390 400 410 420 430
pF1KE6 GYALEPPGPPNAIECVDPTEPHWNDTEPACKAMCGGELSEPAGVVLSPDWPQSYSPGQDC
::.:: . :::::: .:.::.:::::.:.:.::... :::::::.::. :. ::::
NP_001 GYTLEQGSI--IIECVDPHDPQWNETEPACRAVCSGEITDSAGVVLSPNWPEPYGRGQDC
440 450 460 470 480 490
440 450 460 470 480 490
pF1KE6 VWGVHVQEEKRILLQVEILNVREGDMLTLFDGDGPSARVLAQLRGPQPRRRLLSSGPDLT
.:::::.:.:::.:....: . ::.::..::: .::::.: ::. . .:..: :.:
NP_001 IWGVHVEEDKRIMLDIRVLRIGPGDVLTFYDGDDLTARVLGQYSGPRSHFKLFTSMADVT
500 510 520 530 540 550
500 510 520 530 540 550
pF1KE6 LQFQAPPGPPNPGLGQGFVLHFKEVPRNDTCPELPPPEWGWRTASHGDLIRGTVLTYQCE
.:::. :: : ::::.:: :::::::::::: ::.. :. .:..:::.::::
NP_001 IQFQSDPGTSVLGYQQGFVIHFFEVPRNDTCPELPEIPNGWKSPSQPELVHGTVVTYQCY
560 570 580 590 600 610
560 570 580 590 600 610
pF1KE6 PGYELLGSDILTCQWDLSWSAAPPACQKIMTCADPGEIANGHRTASDAGFPVGSHVQYRC
:::...::..: :::::.:: :.::.. .: :::.. ...: :. ::::. ::: :
NP_001 PGYQVVGSSVLMCQWDLTWSEDLPSCQRVTSCHDPGDVEHSRRLISSPKFPVGATVQYIC
620 630 640 650 660 670
620 630 640 650 660 670
pF1KE6 LPGYSLEGAAMLTCYSRDTGTPKWSDRVPKCAL-KYEPCLNPGVPENGYQTLYKHHYQAG
:. : :...:::..:..:.::::::.::: : . .:: . ..:::: .. :. . ::
NP_001 DQGFVLMGSSILTCHDRQAGSPKWSDRAPKCLLEQLKPCHGLSAPENGARSPEKQLHPAG
680 690 700 710 720 730
680 690 700 710 720 730
pF1KE6 ESLRFFCYEGFELIGEVTITCVPGHPSQWTSQPPLCKVA-YEELLDNRKLEVTQTTDPSR
...: : :. : :...: :::::::.:.. ::.:..: . . ..:.:.:... :
NP_001 ATIHFSCAPGYVLKGQASIKCVPGHPSHWSDPPPICRAASLDGFYNSRSLDVAKAPAASS
740 750 760 770 780 790
740 750 760 770 780 790
pF1KE6 QLEGGNLALAILLPLGLVIVLGSGVYIYYTKLQGKSLFGFSGSHS--YSPITVESDFSNP
:.....: ::.::: ...: .:::.:...::::: . . . :. ::.:: :.::
NP_001 TLDAAHIAAAIFLPLVAMVLLVGGVYFYFSRLQGKSSLQLPRPRPRPYNRITIESAFDNP
800 810 820 830 840 850
800
pF1KE6 LYEAGDTREYEVSI
::.:
NP_001 TYETGSLSFAGDERI
860
809 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 15:47:49 2016 done: Tue Nov 8 15:47:50 2016
Total Scan time: 11.480 Total Display time: 0.210
Function used was FASTA [36.3.4 Apr, 2011]