Result of FASTA (omim) for
pFN21AE6720
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6720, 753 aa
1>>>pF1KE6720 753 - 753 aa - 753 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4619+/-0.000489; mu= 19.3793+/- 0.030
mean_var=69.9530+/-13.999, 0's: 0 Z-trim(108.4): 302 B-trim: 175 in 1/53
Lambda= 0.153345
statistics sampled from 16230 (16533) to 16230 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.536), E-opt: 0.2 (0.194), width: 16
Scan time: 8.220
The best scores are: opt bits E(85289)
NP_004290 (OMIM: 300135,301310) ATP-binding casset ( 753) 4872 1087.9 0
NP_001258625 (OMIM: 300135,301310) ATP-binding cas ( 752) 4853 1083.7 0
NP_001258627 (OMIM: 300135,301310) ATP-binding cas ( 726) 4316 964.8 0
NP_001258626 (OMIM: 300135,301310) ATP-binding cas ( 712) 3827 856.7 0
NP_001258628 (OMIM: 300135,301310) ATP-binding cas ( 713) 3827 856.7 0
NP_005680 (OMIM: 111600,605452,609153,614497,61540 ( 842) 1585 360.7 1.4e-98
NP_036221 (OMIM: 605454) ATP-binding cassette sub- ( 738) 801 187.2 2.1e-46
XP_011542437 (OMIM: 605454) PREDICTED: ATP-binding ( 559) 766 179.4 3.5e-44
NP_001157413 (OMIM: 611785) ATP-binding cassette s (1257) 765 179.4 8.1e-44
XP_011536398 (OMIM: 605453) PREDICTED: ATP-binding ( 766) 754 176.8 2.9e-43
XP_016874592 (OMIM: 605453) PREDICTED: ATP-binding ( 766) 754 176.8 2.9e-43
NP_062571 (OMIM: 605453) ATP-binding cassette sub- ( 766) 754 176.8 2.9e-43
XP_011536397 (OMIM: 605453) PREDICTED: ATP-binding ( 766) 754 176.8 2.9e-43
XP_005253615 (OMIM: 605453) PREDICTED: ATP-binding ( 548) 741 173.9 1.6e-42
XP_011536400 (OMIM: 605453) PREDICTED: ATP-binding ( 548) 741 173.9 1.6e-42
NP_000918 (OMIM: 120080,171050,612244) multidrug r (1280) 743 174.5 2.4e-42
XP_011542438 (OMIM: 605454) PREDICTED: ATP-binding ( 442) 730 171.4 7.2e-42
NP_009119 (OMIM: 605464) ATP-binding cassette sub- ( 718) 726 170.6 2e-41
NP_001269220 (OMIM: 605464) ATP-binding cassette s ( 735) 726 170.6 2e-41
NP_001269222 (OMIM: 605464) ATP-binding cassette s ( 630) 725 170.4 2.1e-41
XP_011514615 (OMIM: 171060,600803,602347,614972) P (1232) 720 169.4 7.9e-41
NP_061338 (OMIM: 171060,600803,602347,614972) phos (1232) 720 169.4 7.9e-41
XP_011514614 (OMIM: 171060,600803,602347,614972) P (1247) 720 169.4 8e-41
XP_011514613 (OMIM: 171060,600803,602347,614972) P (1251) 720 169.4 8e-41
XP_011514612 (OMIM: 171060,600803,602347,614972) P (1259) 720 169.4 8e-41
NP_000434 (OMIM: 171060,600803,602347,614972) phos (1279) 720 169.4 8.1e-41
NP_061337 (OMIM: 171060,600803,602347,614972) phos (1286) 720 169.4 8.2e-41
XP_011514611 (OMIM: 171060,600803,602347,614972) P (1287) 720 169.4 8.2e-41
XP_011514610 (OMIM: 171060,600803,602347,614972) P (1294) 720 169.4 8.2e-41
XP_016867812 (OMIM: 171060,600803,602347,614972) P (1294) 720 169.4 8.2e-41
XP_011510383 (OMIM: 601847,603201,605479) PREDICTE ( 763) 681 160.7 2.1e-38
XP_011514617 (OMIM: 171060,600803,602347,614972) P (1074) 682 161.0 2.4e-38
XP_011510382 (OMIM: 601847,603201,605479) PREDICTE ( 936) 652 154.3 2.1e-36
NP_000584 (OMIM: 170260,604571) antigen peptide tr ( 808) 650 153.8 2.5e-36
XP_016860654 (OMIM: 601847,603201,605479) PREDICTE (1314) 652 154.4 2.8e-36
NP_003733 (OMIM: 601847,603201,605479) bile salt e (1321) 652 154.4 2.8e-36
XP_006712880 (OMIM: 601847,603201,605479) PREDICTE (1335) 652 154.4 2.8e-36
XP_011510380 (OMIM: 601847,603201,605479) PREDICTE (1355) 652 154.4 2.9e-36
XP_011510379 (OMIM: 601847,603201,605479) PREDICTE (1355) 652 154.4 2.9e-36
NP_001278951 (OMIM: 170260,604571) antigen peptide ( 547) 644 152.4 4.6e-36
XP_016860655 (OMIM: 601847,603201,605479) PREDICTE (1098) 637 151.0 2.4e-35
NP_001269221 (OMIM: 605464) ATP-binding cassette s ( 693) 614 145.8 5.6e-34
NP_001229943 (OMIM: 605453) ATP-binding cassette s ( 681) 613 145.6 6.4e-34
NP_982269 (OMIM: 605453) ATP-binding cassette sub- ( 683) 612 145.4 7.5e-34
NP_062570 (OMIM: 605453) ATP-binding cassette sub- ( 723) 600 142.8 5e-33
XP_016860656 (OMIM: 601847,603201,605479) PREDICTE ( 916) 599 142.6 7e-33
NP_001276972 (OMIM: 170261,604571) antigen peptide ( 686) 585 139.4 4.7e-32
NP_000535 (OMIM: 170261,604571) antigen peptide tr ( 703) 580 138.3 1e-31
NP_001306961 (OMIM: 605251) multidrug resistance-a ( 965) 580 138.4 1.4e-31
XP_016874593 (OMIM: 605453) PREDICTED: ATP-binding ( 485) 576 137.3 1.4e-31
>>NP_004290 (OMIM: 300135,301310) ATP-binding cassette s (753 aa)
initn: 4872 init1: 4872 opt: 4872 Z-score: 5821.5 bits: 1087.9 E(85289): 0
Smith-Waterman score: 4872; 100.0% identity (100.0% similar) in 753 aa overlap (1-753:1-753)
10 20 30 40 50 60
pF1KE6 MALLAMHSWRWAAAAAAFEKRRHSAILIRPLVSVSGSGPQWRPHQLGALGTARAYQQIPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MALLAMHSWRWAAAAAAFEKRRHSAILIRPLVSVSGSGPQWRPHQLGALGTARAYQQIPE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 SLKSITWQRLGKGNSGQFLDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKEGLKDVDTRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SLKSITWQRLGKGNSGQFLDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKEGLKDVDTRK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 IIKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 IIKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 DAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 FHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 TLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 LKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQ
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 LSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 EYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE6 SLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYD
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE6 TQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 TQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE6 SIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPK
670 680 690 700 710 720
730 740 750
pF1KE6 WEAKKENISKEEERKKLQEEIVNSVKGCGNCSC
:::::::::::::::::::::::::::::::::
NP_004 WEAKKENISKEEERKKLQEEIVNSVKGCGNCSC
730 740 750
>>NP_001258625 (OMIM: 300135,301310) ATP-binding cassett (752 aa)
initn: 4490 init1: 4490 opt: 4853 Z-score: 5798.8 bits: 1083.7 E(85289): 0
Smith-Waterman score: 4853; 99.9% identity (99.9% similar) in 753 aa overlap (1-753:1-752)
10 20 30 40 50 60
pF1KE6 MALLAMHSWRWAAAAAAFEKRRHSAILIRPLVSVSGSGPQWRPHQLGALGTARAYQQIPE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::
NP_001 MALLAMHSWRWAAAAAAFEKRRHSAILIRPLVSVSGSGPQWRPHQLGALGTARAYQ-IPE
10 20 30 40 50
70 80 90 100 110 120
pF1KE6 SLKSITWQRLGKGNSGQFLDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKEGLKDVDTRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLKSITWQRLGKGNSGQFLDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKEGLKDVDTRK
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE6 IIKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IIKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLS
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE6 DAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLG
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE6 FHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLG
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE6 TLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGF
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE6 LKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQ
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE6 LSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHF
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE6 EYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDV
480 490 500 510 520 530
550 560 570 580 590 600
pF1KE6 SLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYD
540 550 560 570 580 590
610 620 630 640 650 660
pF1KE6 TQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRT
600 610 620 630 640 650
670 680 690 700 710 720
pF1KE6 SIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPK
660 670 680 690 700 710
730 740 750
pF1KE6 WEAKKENISKEEERKKLQEEIVNSVKGCGNCSC
:::::::::::::::::::::::::::::::::
NP_001 WEAKKENISKEEERKKLQEEIVNSVKGCGNCSC
720 730 740 750
>>NP_001258627 (OMIM: 300135,301310) ATP-binding cassett (726 aa)
initn: 4316 init1: 4316 opt: 4316 Z-score: 5156.9 bits: 964.8 E(85289): 0
Smith-Waterman score: 4629; 96.4% identity (96.4% similar) in 753 aa overlap (1-753:1-726)
10 20 30 40 50 60
pF1KE6 MALLAMHSWRWAAAAAAFEKRRHSAILIRPLVSVSGSGPQWRPHQLGALGTARAYQQIPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MALLAMHSWRWAAAAAAFEKRRHSAILIRPLVSVSGSGPQWRPHQLGALGTARAYQ----
10 20 30 40 50
70 80 90 100 110 120
pF1KE6 SLKSITWQRLGKGNSGQFLDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKEGLKDVDTRK
:::::::::::::::::::::::::::::::::::::
NP_001 -----------------------ALQVWPLIEKRTCWHGHAGGGLHTDPKEGLKDVDTRK
60 70 80 90
130 140 150 160 170 180
pF1KE6 IIKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IIKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLS
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE6 DAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLG
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE6 FHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLG
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE6 TLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGF
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE6 LKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQ
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE6 LSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHF
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE6 EYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDV
460 470 480 490 500 510
550 560 570 580 590 600
pF1KE6 SLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYD
520 530 540 550 560 570
610 620 630 640 650 660
pF1KE6 TQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRT
580 590 600 610 620 630
670 680 690 700 710 720
pF1KE6 SIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPK
640 650 660 670 680 690
730 740 750
pF1KE6 WEAKKENISKEEERKKLQEEIVNSVKGCGNCSC
:::::::::::::::::::::::::::::::::
NP_001 WEAKKENISKEEERKKLQEEIVNSVKGCGNCSC
700 710 720
>>NP_001258626 (OMIM: 300135,301310) ATP-binding cassett (712 aa)
initn: 4193 init1: 3825 opt: 3827 Z-score: 4572.4 bits: 856.7 E(85289): 0
Smith-Waterman score: 4501; 94.6% identity (94.6% similar) in 753 aa overlap (1-753:1-712)
10 20 30 40 50 60
pF1KE6 MALLAMHSWRWAAAAAAFEKRRHSAILIRPLVSVSGSGPQWRPHQLGALGTARAYQQIPE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::: :::
NP_001 MALLAMHSWRWAAAAAAFEKRRHSAILIRPLVSVSGSGPQWRPHQLGALGTARAYQ-IPE
10 20 30 40 50
70 80 90 100 110 120
pF1KE6 SLKSITWQRLGKGNSGQFLDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKEGLKDVDTRK
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLKSITWQRLGKGNSGQFLDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKEG--------
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE6 IIKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLS
::::::::::::::::::::::::::::
NP_001 --------------------------------AMNIVVPFMFKYAVDSLNQMSGNMLNLS
120 130
190 200 210 220 230 240
pF1KE6 DAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLG
140 150 160 170 180 190
250 260 270 280 290 300
pF1KE6 FHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLG
200 210 220 230 240 250
310 320 330 340 350 360
pF1KE6 TLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGF
260 270 280 290 300 310
370 380 390 400 410 420
pF1KE6 LKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQ
320 330 340 350 360 370
430 440 450 460 470 480
pF1KE6 LSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHF
380 390 400 410 420 430
490 500 510 520 530 540
pF1KE6 EYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDV
440 450 460 470 480 490
550 560 570 580 590 600
pF1KE6 SLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYD
500 510 520 530 540 550
610 620 630 640 650 660
pF1KE6 TQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRT
560 570 580 590 600 610
670 680 690 700 710 720
pF1KE6 SIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPK
620 630 640 650 660 670
730 740 750
pF1KE6 WEAKKENISKEEERKKLQEEIVNSVKGCGNCSC
:::::::::::::::::::::::::::::::::
NP_001 WEAKKENISKEEERKKLQEEIVNSVKGCGNCSC
680 690 700 710
>>NP_001258628 (OMIM: 300135,301310) ATP-binding cassett (713 aa)
initn: 3825 init1: 3825 opt: 3827 Z-score: 4572.4 bits: 856.7 E(85289): 0
Smith-Waterman score: 4520; 94.7% identity (94.7% similar) in 753 aa overlap (1-753:1-713)
10 20 30 40 50 60
pF1KE6 MALLAMHSWRWAAAAAAFEKRRHSAILIRPLVSVSGSGPQWRPHQLGALGTARAYQQIPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MALLAMHSWRWAAAAAAFEKRRHSAILIRPLVSVSGSGPQWRPHQLGALGTARAYQQIPE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 SLKSITWQRLGKGNSGQFLDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKEGLKDVDTRK
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLKSITWQRLGKGNSGQFLDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKEG--------
70 80 90 100 110
130 140 150 160 170 180
pF1KE6 IIKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLS
::::::::::::::::::::::::::::
NP_001 --------------------------------AMNIVVPFMFKYAVDSLNQMSGNMLNLS
120 130 140
190 200 210 220 230 240
pF1KE6 DAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLG
150 160 170 180 190 200
250 260 270 280 290 300
pF1KE6 FHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLG
210 220 230 240 250 260
310 320 330 340 350 360
pF1KE6 TLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGF
270 280 290 300 310 320
370 380 390 400 410 420
pF1KE6 LKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQ
330 340 350 360 370 380
430 440 450 460 470 480
pF1KE6 LSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHF
390 400 410 420 430 440
490 500 510 520 530 540
pF1KE6 EYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDV
450 460 470 480 490 500
550 560 570 580 590 600
pF1KE6 SLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYD
510 520 530 540 550 560
610 620 630 640 650 660
pF1KE6 TQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRT
570 580 590 600 610 620
670 680 690 700 710 720
pF1KE6 SIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPK
630 640 650 660 670 680
730 740 750
pF1KE6 WEAKKENISKEEERKKLQEEIVNSVKGCGNCSC
:::::::::::::::::::::::::::::::::
NP_001 WEAKKENISKEEERKKLQEEIVNSVKGCGNCSC
690 700 710
>>NP_005680 (OMIM: 111600,605452,609153,614497,615402) A (842 aa)
initn: 1512 init1: 808 opt: 1585 Z-score: 1890.7 bits: 360.7 E(85289): 1.4e-98
Smith-Waterman score: 1585; 42.0% identity (73.4% similar) in 610 aa overlap (117-720:241-836)
90 100 110 120 130 140
pF1KE6 VWPLIEKRTCWHGHAGGGLHTDPKEGLKDVDTRKIIKAMLSYVWPKDRPDLRARVAISLG
: . .. . .:.::. : :. : : ::
NP_005 PQSYTLQVHEEDQDVERSQVRSAAQQSTWRDFGRKLRLLSGYLWPRGSPALQLVVLICLG
220 230 240 250 260 270
150 160 170 180 190 200
pF1KE6 FLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLSDAP-NTVA-TMATAVLIGY--GVSRA
..: .:.:..::.... :. :.. :: :..: :... :.. . : . .
NP_005 LMGLERALNVLVPIFYRNIVNLLTE---------KAPWNSLAWTVTSYVFLKFLQGGGTG
280 290 300 310 320
210 220 230 240 250 260
pF1KE6 GAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQTGALSKAIDRGTRGIS
...: ...:. .. .: : . ::. .: :::.:.: .::.:.:: . . :::: ...
NP_005 STGFVSNLRTFLWIRVQQFTSRRVELLIFSHLHELSLRWHLGRRTGEVLRIADRGTSSVT
330 340 350 360 370 380
270 280 290 300 310 320
pF1KE6 FVLSALVFNLLPIMFEVMLVSGVLYYKC--GAQFALVTLGTLGTYTAFTVAVTRWRTRFR
.:: ::::..: . .... :..:.. .: :.:... .. : ..:..::.:::.::
NP_005 GLLSYLVFNVIPTLADIII--GIIYFSMFFNAWFGLIVFLCMSLYLTLTIVVTEWRTKFR
390 400 410 420 430
330 340 350 360 370 380
pF1KE6 IEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTSTLAMLNF
:: .: . :.:::::.:::::.: : ::..:: . :. ::...:..::
NP_005 RAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQGLEWKSSASLVLLNQ
440 450 460 470 480 490
390 400 410 420 430 440
pF1KE6 GQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALI
:. ....:: : .: . .. : ::: :. . ..:: .:::..:: :: . .:
NP_005 TQNLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYRMIQTNFI
500 510 520 530 540 550
450 460 470 480 490 500
pF1KE6 DMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIEGQKVLSGISFEVPAGK
::...: ::: .:..:: :.::.. : . . :.:::: : .:...:. .:: : :.
NP_005 DMENMFDLLKEETEVKDLPGAGPLRF--QKGRIEFENVHFSYADGRETLQDVSFTVMPGQ
560 570 580 590 600 610
510 520 530 540 550 560
pF1KE6 KVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFH
.:.:: ::.:::::.:::::::. ..: : . ::.:..:. ::: .::::::.:::.
NP_005 TLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFN
620 630 640 650 660 670
570 580 590 600 610 620
pF1KE6 NTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAI
.:: :. :: ..:. .:: :.:. ::.::::. .:.:: ::::::::::::::::::::
NP_005 DTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAI
680 690 700 710 720 730
630 640 650 660 670 680
pF1KE6 ARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVL
::.::: : .:: :::::.::. .:..: ... : .::.: .::::::::.::.:.:.
NP_005 ARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVI
740 750 760 770 780 790
690 700 710 720 730 740
pF1KE6 DQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPKWEAKKENISKEEERKKLQEE
.: ..::: :..::. ..:..::. :... .. .. :
NP_005 KDGCIVERGRHEALLSRG-GVYADMWQLQQGQEETSEDTKPQTMER
800 810 820 830 840
750
pF1KE6 IVNSVKGCGNCSC
>>NP_036221 (OMIM: 605454) ATP-binding cassette sub-fami (738 aa)
initn: 630 init1: 415 opt: 801 Z-score: 954.2 bits: 187.2 E(85289): 2.1e-46
Smith-Waterman score: 803; 29.5% identity (61.9% similar) in 599 aa overlap (123-710:158-734)
100 110 120 130 140 150
pF1KE6 KRTCWHGHAGGGLHTDPKEGLKDVDTRKIIKAMLSYVWPKDRPDLRARVAISLGFLGGAK
. .:. ..:. : :.: ..::: ..
NP_036 AGDEAWRRGPAAPPGDKGRLRPAAAGLPEARKLLGLAYPERR-----RLAAAVGFLTMSS
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE6 AMNIVVPFMFKYAVDSLNQMSGNMLNLSDAPNTVATMATAVLIGYGVSRAGAAFFNEVRN
.... .::.. .: . ... .. :: . . .::.. ::: : .:
NP_036 VISMSAPFFLGKIIDVI--YTNPTVDYSDNLTRLCLGLSAVFL------CGAAA-NAIRV
190 200 210 220 230
220 230 240 250 260 270
pF1KE6 AVFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQTGALSKAIDRGTRGISFVLSALVFNL
.. .: . :. ..: . ...: . .:: : :.: . ... ... ::
NP_036 YLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGEL---INRLSSDTALLGRSVTENL
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE6 LPIMFEVMLVS-GV-LYYKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDA
. .: :. ... . ..: .:... . ..: :. .. . . .:
NP_036 SDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQA
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE6 GNAAIDSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTSTLAMLNFGQSAIFSVGL
. : . . : .::. :..: : ..: . :. .. .: ..: .: .. .: .:
NP_036 TQLAEERIGNVRTVRAFGKEMTEIEKYAS--KVDHVMQLARKEAFARAGFFGATGLSGNL
360 370 380 390 400
400 410 420 430 440
pF1KE6 TAIMVLASQGIVAGT--LTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTL
.. :: . :.. :. .:::.: : ... .. :.. : : ..: . :. :
NP_036 IVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWEL
410 420 430 440 450 460
450 460 470 480 490 500
pF1KE6 LKVDTQI--KDKVMASPLQITPQTATVAFDNVHFEYIEGQKV--LSGISFEVPAGKKVAI
:. . .. .. :. . . . : : . : :::: : .: .. .:. .:.:. .:.
NP_036 LEREPKLPFNEGVILN--EKSFQGA-LEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTAL
470 480 490 500 510 520
510 520 530 540 550 560
pF1KE6 VGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIY
:: :::::::.. ::.:.:.: .:.: : :..:.... :: .:.: :. .:: .:
NP_036 VGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIA
530 540 550 560 570 580
570 580 590 600 610 620
pF1KE6 YNLLYGN---ISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIA
:. :: :.. ::. ::..:. : .:.:..: :::.:. ::::.:::.:::
NP_036 ENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIA
590 600 610 620 630 640
630 640 650 660 670 680
pF1KE6 RAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLD
::.::.: ..: :::::.::. .: . :. .. :: . :::::::. .:. . :::
NP_036 RALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLD
650 660 670 680 690 700
690 700 710 720 730 740
pF1KE6 QGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPKWEAKKENISKEEERKKLQEEI
:::..: : :. ::..:..:: .. . ::
NP_036 QGKITEYGKHEELLSKPNGIYRKLMNKQSFISA
710 720 730
>>XP_011542437 (OMIM: 605454) PREDICTED: ATP-binding cas (559 aa)
initn: 660 init1: 415 opt: 766 Z-score: 914.2 bits: 179.4 E(85289): 3.5e-44
Smith-Waterman score: 766; 29.6% identity (62.0% similar) in 571 aa overlap (151-710:2-555)
130 140 150 160 170 180
pF1KE6 IIKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLS
...... .::.. .: . ... .. :
XP_011 MSSVISMSAPFFLGKIIDVI--YTNPTVDYS
10 20
190 200 210 220 230 240
pF1KE6 DAPNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLG
: . . .::.. ::: : .: .. .: . :. ..: . ...
XP_011 DNLTRLCLGLSAVFL------CGAAA-NAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVA
30 40 50 60 70 80
250 260 270 280 290
pF1KE6 FHLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVS-GV-LYYKCGAQFALVT
: . .:: : :.: . ... ... :: . .: :. ... . ..: .
XP_011 FFDKTRTGEL---INRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFV
90 100 110 120 130
300 310 320 330 340 350
pF1KE6 LGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYD
:... . ..: :. .. . . .: . : . . : .::. :..: : ..:
XP_011 LSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYA
140 150 160 170 180 190
360 370 380 390 400 410
pF1KE6 GFLKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGT--LTVGDLVMVNG
. :. .. .: ..: .: .. .: .: .. :: . :.. :. .:::.:
XP_011 S--KVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLM
200 210 220 230 240 250
420 430 440 450 460 470
pF1KE6 LLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQI--KDKVMASPLQITPQTATVA
: ... .. :.. : : ..: . :. ::. . .. .. :. . . . : : .
XP_011 YAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILN--EKSFQGA-LE
260 270 280 290 300 310
480 490 500 510 520 530
pF1KE6 FDNVHFEYIEGQKV--LSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYL
: :::: : .: .. .:. .:.:. .:.:: :::::::.. ::.:.:.: .:.: :
XP_011 FKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISL
320 330 340 350 360 370
540 550 560 570 580
pF1KE6 AGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGN---ISASPEEVYAVAKLAGLH
:..:.... :: .:.: :. .:: .: :. :: :.. ::. ::..:.
XP_011 DGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAV
380 390 400 410 420 430
590 600 610 620 630 640
pF1KE6 DAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETIL
: .:.:..: :::.:. ::::.:::.:::::.::.: ..: :::::.::. .: .
XP_011 AFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQ
440 450 460 470 480 490
650 660 670 680 690 700
pF1KE6 GAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQ
:. .. :: . :::::::. .:. . ::::::..: : :. ::..:..:: .. . :
XP_011 EALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQ
500 510 520 530 540 550
710 720 730 740 750
pF1KE6 SSRVQNHDNPKWEAKKENISKEEERKKLQEEIVNSVKGCGNCSC
:
XP_011 SFISA
>>NP_001157413 (OMIM: 611785) ATP-binding cassette sub-f (1257 aa)
initn: 669 init1: 599 opt: 765 Z-score: 907.7 bits: 179.4 E(85289): 8.1e-44
Smith-Waterman score: 765; 30.9% identity (60.8% similar) in 576 aa overlap (184-746:100-655)
160 170 180 190 200 210
pF1KE6 MNIVVPFMFKYAVDSLNQMSGNMLNLSDAPNTVATMATAVLIGYGVSRAGAAFFNEVRNA
: :. : .: ::. : .:. .. .
NP_001 GEMSDNLISGCLVQTNTTNYQNCTQSQEKLNEDMTLLTLYYVGIGVA---ALIFGYIQIS
70 80 90 100 110 120
220 230 240 250 260
pF1KE6 VFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQTGAL----SKAIDRGTRGISFVLSALV
.. .: . .:: :. : . :.:. : . : : . ::. . ::. . ::.
NP_001 LWIITAARQTKRIRKQFFHSVLAQDIGWFDSCDIGELNTRMTDDIDKISDGIGDKI-ALL
130 140 150 160 170 180
270 280 290 300 310 320
pF1KE6 FNLLPIMFEVMLVSGVLYYKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADND
:. . : . :. :.. : ...::::.: : ..: .: . . .: .
NP_001 FQNMST-FSIGLAVGLVK---GWKLTLVTLSTSPLIMASAAACSRMVISLTSKELSAYSK
190 200 210 220 230 240
330 340 350 360 370 380
pF1KE6 AGNAAIDSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTSTLAMLNFGQSAIFSVG
:: .: . : . .:: : .. : ::: :: . ..: : . ...: .: :
NP_001 AGAVAEEVLSSIRTVIAFRAQEKELQRYTQNLKDAKDFGIKRT-IASKVSLGAVYFFMNG
250 260 270 280 290 300
390 400 410 420 430 440
pF1KE6 LTAIMV-LASQGIVAGT--LTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLF
.. ... :. : :.: .. : .:.. .:.. . . : .. :
NP_001 TYGLAFWYGTSLILNGEPGYTIGTVLAV---FFSVIHSSYCIGAAVPHFETFAIARGAAF
310 320 330 340 350
450 460 470 480 490 500
pF1KE6 TLLKVDTQIKDKVMASPLQITPQT--ATVAFDNVHFEYIE--GQKVLSGISFEVPAGKKV
...: . . : :.. .:: : :: :.: . :.:.:..... .:. :
NP_001 HIFQVIDKKPSIDNFSTAGYKPESIEGTVEFKNVSFNYPSRPSIKILKGLNLRIKSGETV
360 370 380 390 400 410
510 520 530 540 550 560
pF1KE6 AIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNT
:.:: .::::::.:.:: :.:.:. : :.. ..:. .... : .::: :. ::: .:
NP_001 ALVGLNGSGKSTVVQLLQRLYDPDDGFIMVDENDIRALNVRHYRDHIGVVSQEPVLFGTT
420 430 440 450 460 470
570 580 590 600 610 620
pF1KE6 IYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIAR
: :. :: ... ::. .:. :. .: :...:. ..: :::.: ..:::.:::.::::
NP_001 ISNNIKYGRDDVTDEEMERAAREANAYDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIAR
480 490 500 510 520 530
630 640 650 660 670 680
pF1KE6 AILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQ
:....: ... :::::.::: .. .. .:.. . : ::.: .::::::. .:: :..: .
NP_001 ALVRNPKILILDEATSALDSESKSAVQAALEKASKGRTTIVVAHRLSTIRSADLIVTLKD
540 550 560 570 580 590
690 700 710 720 730 740
pF1KE6 GKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPKWEAKKENISKEEERK--KLQEE
: .::.:.: :.:. : : :...: : . . :... ::: .: .
NP_001 GMLAEKGAHAELMAKRGLYY--------SLVMSQDIKKADEQMESMTYSTERKTNSLPLH
600 610 620 630 640
750
pF1KE6 IVNSVKGCGNCSC
:.:.:
NP_001 SVKSIKSDFIDKAEESTQSKEISLPEVSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVF
650 660 670 680 690 700
>--
initn: 544 init1: 319 opt: 668 Z-score: 791.7 bits: 157.9 E(85289): 2.3e-37
Smith-Waterman score: 668; 28.1% identity (59.2% similar) in 613 aa overlap (107-710:666-1255)
80 90 100 110 120 130
pF1KE6 QFLDAAKALQVWPLIEKRTCWHGHAGGGLHTDPKE-GLKDVDTRKIIKAMLSYVWPKDRP
:. :: .: .:. ::.: . . ::
NP_001 TYSTERKTNSLPLHSVKSIKSDFIDKAEESTQSKEISLPEVSLLKILK-LNKPEWP----
640 650 660 670 680 690
140 150 160 170 180 190
pF1KE6 DLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLSDAPNTVATMATAVLI
. :: : :...: .: .:. .. : :: : . . . : . . ...
NP_001 ------FVVLGTL--ASVLNGTVHPVFSIIFAKIITMFGN--NDKTTLKHDAEIYSMIFV
700 710 720 730 740
200 210 220 230 240 250
pF1KE6 GYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQ--TGALSKA
:: ...: ... .:.... :. . .: . :... .. ::.:.
NP_001 ILGVI-CFVSYF--MQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTI
750 760 770 780 790
260 270 280 290 300 310
pF1KE6 IDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLGTLGTYTAFTVAVT
. :. . .. . ..: : .: .. . : ..... :. . .. . :
NP_001 LAIDIAQIQGATGSRI-GVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIET
800 810 820 830 840 850
320 330 340 350 360 370
pF1KE6 RWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTS
: : . .. . ::. : ..: : .:. .. :. : :. .:.: . . :...
NP_001 AAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKAQ
860 870 880 890 900 910
380 390 400 410 420 430
pF1KE6 TLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYR
.. . :.. . .: . ... : :: .: . .: . .. .. ..
NP_001 IIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVLAP
920 930 940 950 960 970
440 450 460 470 480
pF1KE6 ETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQT--ATVAFDNVHFEYIEGQKV--L
: .: ::.::. .: .. : :.: ... : .: : : : :
NP_001 EYSKAKSGAAHLFALLEKKPNIDSR---SQEGKKPDTCEGNLEFREVSFFYPCRPDVFIL
980 990 1000 1010 1020 1030
490 500 510 520 530 540
pF1KE6 SGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAV
:.:. . :: ::.::.:: :::: :.:: :.:.: .:.. . : . ...... :: .
NP_001 RGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQI
1040 1050 1060 1070 1080 1090
550 560 570 580 590 600
pF1KE6 GVVPQDAVLFHNTIYYNLLYGNIS-ASP-EEVYAVAKLAGLHDAILRMPHGYDTQVGERG
..:::. :::. .: :. ::. : . : .:. .:. :..:. : .:. :.:::: .:
NP_001 AIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKG
1100 1110 1120 1130 1140 1150
610 620 630 640 650 660
pF1KE6 LKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHR
.::::.:::.:::::.:. : ..: :::::.::. .:... :. . :: . ..::
NP_001 AQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHR
1160 1170 1180 1190 1200 1210
670 680 690 700 710 720
pF1KE6 LSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPKWEAKKEN
::.. .:: :.:: .::. :.:::. :: : ..:: .. ..::
NP_001 LSAIQNADLIVVLHNGKIKEQGTHQELLRN-RDIYFKLVNAQSVQ
1220 1230 1240 1250
730 740 750
pF1KE6 ISKEEERKKLQEEIVNSVKGCGNCSC
>>XP_011536398 (OMIM: 605453) PREDICTED: ATP-binding cas (766 aa)
initn: 597 init1: 564 opt: 754 Z-score: 897.8 bits: 176.8 E(85289): 2.9e-43
Smith-Waterman score: 776; 29.8% identity (60.7% similar) in 593 aa overlap (122-709:174-741)
100 110 120 130 140 150
pF1KE6 EKRTCWHGHAGGGLHTDPKEGLKDVDTRKIIKAMLSYVWPKDRPDLRARVAISLGFLGGA
.. .:::. .::. :: :. :: :
XP_011 TQALEPGAATEAEGFPGSGRPPPEQASGATLQKLLSYT----KPDVAFLVAASF-FLIVA
150 160 170 180 190
160 170 180 190 200 210
pF1KE6 KAMNIVVPFMFKYAVDSLNQMSGNMLNLSDAPNTVATMATAVLIGYGVSRAGAAFFNEVR
. .:.. :.:.. .. .: ..: : : .: :..: .:
XP_011 ALGETFLPYYTGRAIDGIV-IQKSMDQFSTAVVIVCLLAI-----------GSSFAAGIR
200 210 220 230 240
220 230 240 250 260 270
pF1KE6 NAVFGKVAQNSIRRIAKNVFLHLHNLDLGFHLSRQTGALSKAIDRGTRGISFVLSALVFN
...: . :. . .: : . . .: .:: : :.: : ..: . . :
XP_011 GGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDL---ISRLTSDTTMVSDLVSQN
250 260 270 280 290 300
280 290 300 310 320
pF1KE6 LLPIMFEVMLVSGVL--YYKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADND
. .. ... :.::. ... . :..:::. . . .. :. :...:
XP_011 INVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALAR
310 320 330 340 350 360
330 340 350 360 370 380
pF1KE6 AGNAAIDSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTSTLAMLNFGQSAIFSVG
:.:.: ... ..::. : ::. ::. : :. . : ... . .:.. . :
XP_011 ASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVV
370 380 390 400 410 420
390 400 410 420 430 440
pF1KE6 LTAIMVLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLL
..:. ... ...: .: :.:. : :. .. .:.:: :.. . .: ..
XP_011 QVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFI
430 440 450 460 470 480
450 460 470 480 490 500
pF1KE6 -KVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIE--GQKVLSGISFEVPAGKKVAIVG
. :...: .: : .. . : :.:: : : .::...:: . :: .:.::
XP_011 DRQPTMVHDGSLA-PDHLEGR---VDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVG
490 500 510 520 530
510 520 530 540 550 560
pF1KE6 GSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYN
::::::. : .: :: . : . : :. :. . . :.:....: :. ::: .: :
XP_011 PSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDN
540 550 560 570 580 590
570 580 590 600 610 620
pF1KE6 LLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILK
. :: .. : : .:. :. : :... ::.:..::.: .::::.:::::.:::...
XP_011 ISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVR
600 610 620 630 640 650
630 640 650 660 670 680
pF1KE6 DPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVA
.:::.. :::::.::. .: : :.. ....: ..:::::::: : :.:::.:.:.
XP_011 NPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVV
660 670 680 690 700 710
690 700 710 720 730 740
pF1KE6 ERGTHHGLLANPHSIYSEMWHTQSSRVQNHDNPKWEAKKENISKEEERKKLQEEIVNSVK
..:::. :::. ..:... . :
XP_011 QQGTHQQLLAQG-GLYAKLVQRQMLGLQPAADFTAGHNEPVANGSHKA
720 730 740 750 760
753 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 15:41:49 2016 done: Tue Nov 8 15:41:50 2016
Total Scan time: 8.220 Total Display time: 0.220
Function used was FASTA [36.3.4 Apr, 2011]