Result of FASTA (omim) for
pFN21AE6709
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6709, 713 aa
1>>>pF1KE6709 713 - 713 aa - 713 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2506+/-0.000397; mu= 20.0010+/- 0.025
mean_var=72.6971+/-14.727, 0's: 0 Z-trim(111.7): 21 B-trim: 1012 in 1/53
Lambda= 0.150423
statistics sampled from 20307 (20322) to 20307 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.604), E-opt: 0.2 (0.238), width: 16
Scan time: 6.080
The best scores are: opt bits E(85289)
NP_005923 (OMIM: 602241) mitochondrial intermediat ( 713) 4791 1049.8 0
XP_011533399 (OMIM: 602241) PREDICTED: mitochondri ( 651) 4360 956.2 0
XP_011533400 (OMIM: 602241) PREDICTED: mitochondri ( 621) 4124 905.0 0
XP_011526530 (OMIM: 601117) PREDICTED: thimet olig ( 480) 644 149.7 2.6e-35
NP_003240 (OMIM: 601117) thimet oligopeptidase [Ho ( 689) 644 149.8 3.4e-35
XP_006714724 (OMIM: 611530) PREDICTED: neurolysin, ( 681) 631 147.0 2.4e-34
NP_065777 (OMIM: 611530) neurolysin, mitochondrial ( 704) 631 147.0 2.5e-34
XP_016865162 (OMIM: 611530) PREDICTED: neurolysin, ( 663) 288 72.5 6e-12
XP_005248616 (OMIM: 611530) PREDICTED: neurolysin, ( 686) 288 72.5 6.2e-12
>>NP_005923 (OMIM: 602241) mitochondrial intermediate pe (713 aa)
initn: 4791 init1: 4791 opt: 4791 Z-score: 5616.4 bits: 1049.8 E(85289): 0
Smith-Waterman score: 4791; 100.0% identity (100.0% similar) in 713 aa overlap (1-713:1-713)
10 20 30 40 50 60
pF1KE6 MLCVGRLGGLGARAAALPPRRAGRGSLEAGIRARRVSTSWSPVGAAFNVKPQGSRLDLFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MLCVGRLGGLGARAAALPPRRAGRGSLEAGIRARRVSTSWSPVGAAFNVKPQGSRLDLFG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ERRGLFGVPELSAPEGFHIAQEKALRKTELLVDRACSTPPGPQTVLIFDELSDSLCRVAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ERRGLFGVPELSAPEGFHIAQEKALRKTELLVDRACSTPPGPQTVLIFDELSDSLCRVAD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 LADFVKIAHPEPAFREAAEEACRSIGTMVEKLNTNVDLYQSLQKLLADKKLVDSLDPETR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LADFVKIAHPEPAFREAAEEACRSIGTMVEKLNTNVDLYQSLQKLLADKKLVDSLDPETR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 RVAELFMFDFEISGIHLDKEKRKRAVDLNVKILDLSSTFLMGTNFPNKIEKHLLPEHIRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RVAELFMFDFEISGIHLDKEKRKRAVDLNVKILDLSSTFLMGTNFPNKIEKHLLPEHIRR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 NFTSAGDHIIIDGLHAESPDDLVREAAYKIFLYPNAGQLKCLEELLSSRDLLAKLVGYST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 NFTSAGDHIIIDGLHAESPDDLVREAAYKIFLYPNAGQLKCLEELLSSRDLLAKLVGYST
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 FSHRALQGTIAKNPETVMQFLEKLSDKLSERTLKDFEMIRGMKMKLNPQNSEVMPWDPPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 FSHRALQGTIAKNPETVMQFLEKLSDKLSERTLKDFEMIRGMKMKLNPQNSEVMPWDPPY
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 YSGVIRAERYNIEPSLYCPFFSLGACMEGLNILLNRLLGISLYAEQPAKGEVWSEDVRKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 YSGVIRAERYNIEPSLYCPFFSLGACMEGLNILLNRLLGISLYAEQPAKGEVWSEDVRKL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 AVVHESEGLLGYIYCDFFQRADKPHQDCHFTIRGGRLKEDGDYQLPVVVLMLNLPRSSRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AVVHESEGLLGYIYCDFFQRADKPHQDCHFTIRGGRLKEDGDYQLPVVVLMLNLPRSSRS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 SPTLLTPGMMENLFHEMGHAMHSMLGRTRYQHVTGTRCPTDFAEVPSILMEYFANDYRVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 SPTLLTPGMMENLFHEMGHAMHSMLGRTRYQHVTGTRCPTDFAEVPSILMEYFANDYRVV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE6 NQFARHYQTGQPLPKNMVSRLCESKKVCAAADMQLQVFYATLDQIYHGKHPLRNSTTDIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 NQFARHYQTGQPLPKNMVSRLCESKKVCAAADMQLQVFYATLDQIYHGKHPLRNSTTDIL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE6 KETQEKFYGLPYVPNTAWQLRFSHLVGYGARYYSYLMSRAVASMVWKECFLQDPFNRAAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KETQEKFYGLPYVPNTAWQLRFSHLVGYGARYYSYLMSRAVASMVWKECFLQDPFNRAAG
610 620 630 640 650 660
670 680 690 700 710
pF1KE6 ERYRREMLAHGGGREPMLMVEGMLQKCPSVDDFVSALVSDLDLDFETFLMDSE
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 ERYRREMLAHGGGREPMLMVEGMLQKCPSVDDFVSALVSDLDLDFETFLMDSE
670 680 690 700 710
>>XP_011533399 (OMIM: 602241) PREDICTED: mitochondrial i (651 aa)
initn: 4360 init1: 4360 opt: 4360 Z-score: 5111.4 bits: 956.2 E(85289): 0
Smith-Waterman score: 4360; 99.8% identity (100.0% similar) in 650 aa overlap (64-713:2-651)
40 50 60 70 80 90
pF1KE6 RRVSTSWSPVGAAFNVKPQGSRLDLFGERRGLFGVPELSAPEGFHIAQEKALRKTELLVD
::::::::::::::::::::::::::::::
XP_011 MGLFGVPELSAPEGFHIAQEKALRKTELLVD
10 20 30
100 110 120 130 140 150
pF1KE6 RACSTPPGPQTVLIFDELSDSLCRVADLADFVKIAHPEPAFREAAEEACRSIGTMVEKLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RACSTPPGPQTVLIFDELSDSLCRVADLADFVKIAHPEPAFREAAEEACRSIGTMVEKLN
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE6 TNVDLYQSLQKLLADKKLVDSLDPETRRVAELFMFDFEISGIHLDKEKRKRAVDLNVKIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TNVDLYQSLQKLLADKKLVDSLDPETRRVAELFMFDFEISGIHLDKEKRKRAVDLNVKIL
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE6 DLSSTFLMGTNFPNKIEKHLLPEHIRRNFTSAGDHIIIDGLHAESPDDLVREAAYKIFLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLSSTFLMGTNFPNKIEKHLLPEHIRRNFTSAGDHIIIDGLHAESPDDLVREAAYKIFLY
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE6 PNAGQLKCLEELLSSRDLLAKLVGYSTFSHRALQGTIAKNPETVMQFLEKLSDKLSERTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PNAGQLKCLEELLSSRDLLAKLVGYSTFSHRALQGTIAKNPETVMQFLEKLSDKLSERTL
220 230 240 250 260 270
340 350 360 370 380 390
pF1KE6 KDFEMIRGMKMKLNPQNSEVMPWDPPYYSGVIRAERYNIEPSLYCPFFSLGACMEGLNIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDFEMIRGMKMKLNPQNSEVMPWDPPYYSGVIRAERYNIEPSLYCPFFSLGACMEGLNIL
280 290 300 310 320 330
400 410 420 430 440 450
pF1KE6 LNRLLGISLYAEQPAKGEVWSEDVRKLAVVHESEGLLGYIYCDFFQRADKPHQDCHFTIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LNRLLGISLYAEQPAKGEVWSEDVRKLAVVHESEGLLGYIYCDFFQRADKPHQDCHFTIR
340 350 360 370 380 390
460 470 480 490 500 510
pF1KE6 GGRLKEDGDYQLPVVVLMLNLPRSSRSSPTLLTPGMMENLFHEMGHAMHSMLGRTRYQHV
::::::::::::::::::::::::::::::::::.:::::::::::::::::::::::::
XP_011 GGRLKEDGDYQLPVVVLMLNLPRSSRSSPTLLTPSMMENLFHEMGHAMHSMLGRTRYQHV
400 410 420 430 440 450
520 530 540 550 560 570
pF1KE6 TGTRCPTDFAEVPSILMEYFANDYRVVNQFARHYQTGQPLPKNMVSRLCESKKVCAAADM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGTRCPTDFAEVPSILMEYFANDYRVVNQFARHYQTGQPLPKNMVSRLCESKKVCAAADM
460 470 480 490 500 510
580 590 600 610 620 630
pF1KE6 QLQVFYATLDQIYHGKHPLRNSTTDILKETQEKFYGLPYVPNTAWQLRFSHLVGYGARYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QLQVFYATLDQIYHGKHPLRNSTTDILKETQEKFYGLPYVPNTAWQLRFSHLVGYGARYY
520 530 540 550 560 570
640 650 660 670 680 690
pF1KE6 SYLMSRAVASMVWKECFLQDPFNRAAGERYRREMLAHGGGREPMLMVEGMLQKCPSVDDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYLMSRAVASMVWKECFLQDPFNRAAGERYRREMLAHGGGREPMLMVEGMLQKCPSVDDF
580 590 600 610 620 630
700 710
pF1KE6 VSALVSDLDLDFETFLMDSE
::::::::::::::::::::
XP_011 VSALVSDLDLDFETFLMDSE
640 650
>>XP_011533400 (OMIM: 602241) PREDICTED: mitochondrial i (621 aa)
initn: 4124 init1: 4124 opt: 4124 Z-score: 4834.9 bits: 905.0 E(85289): 0
Smith-Waterman score: 4124; 99.7% identity (99.8% similar) in 619 aa overlap (1-619:1-619)
10 20 30 40 50 60
pF1KE6 MLCVGRLGGLGARAAALPPRRAGRGSLEAGIRARRVSTSWSPVGAAFNVKPQGSRLDLFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MLCVGRLGGLGARAAALPPRRAGRGSLEAGIRARRVSTSWSPVGAAFNVKPQGSRLDLFG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ERRGLFGVPELSAPEGFHIAQEKALRKTELLVDRACSTPPGPQTVLIFDELSDSLCRVAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERRGLFGVPELSAPEGFHIAQEKALRKTELLVDRACSTPPGPQTVLIFDELSDSLCRVAD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 LADFVKIAHPEPAFREAAEEACRSIGTMVEKLNTNVDLYQSLQKLLADKKLVDSLDPETR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LADFVKIAHPEPAFREAAEEACRSIGTMVEKLNTNVDLYQSLQKLLADKKLVDSLDPETR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 RVAELFMFDFEISGIHLDKEKRKRAVDLNVKILDLSSTFLMGTNFPNKIEKHLLPEHIRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RVAELFMFDFEISGIHLDKEKRKRAVDLNVKILDLSSTFLMGTNFPNKIEKHLLPEHIRR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 NFTSAGDHIIIDGLHAESPDDLVREAAYKIFLYPNAGQLKCLEELLSSRDLLAKLVGYST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NFTSAGDHIIIDGLHAESPDDLVREAAYKIFLYPNAGQLKCLEELLSSRDLLAKLVGYST
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 FSHRALQGTIAKNPETVMQFLEKLSDKLSERTLKDFEMIRGMKMKLNPQNSEVMPWDPPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSHRALQGTIAKNPETVMQFLEKLSDKLSERTLKDFEMIRGMKMKLNPQNSEVMPWDPPY
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 YSGVIRAERYNIEPSLYCPFFSLGACMEGLNILLNRLLGISLYAEQPAKGEVWSEDVRKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YSGVIRAERYNIEPSLYCPFFSLGACMEGLNILLNRLLGISLYAEQPAKGEVWSEDVRKL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 AVVHESEGLLGYIYCDFFQRADKPHQDCHFTIRGGRLKEDGDYQLPVVVLMLNLPRSSRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVVHESEGLLGYIYCDFFQRADKPHQDCHFTIRGGRLKEDGDYQLPVVVLMLNLPRSSRS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 SPTLLTPGMMENLFHEMGHAMHSMLGRTRYQHVTGTRCPTDFAEVPSILMEYFANDYRVV
:::::::.::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPTLLTPSMMENLFHEMGHAMHSMLGRTRYQHVTGTRCPTDFAEVPSILMEYFANDYRVV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE6 NQFARHYQTGQPLPKNMVSRLCESKKVCAAADMQLQVFYATLDQIYHGKHPLRNSTTDIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NQFARHYQTGQPLPKNMVSRLCESKKVCAAADMQLQVFYATLDQIYHGKHPLRNSTTDIL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE6 KETQEKFYGLPYVPNTAWQLRFSHLVGYGARYYSYLMSRAVASMVWKECFLQDPFNRAAG
::::::::::::::::: :
XP_011 KETQEKFYGLPYVPNTAVQEA
610 620
>>XP_011526530 (OMIM: 601117) PREDICTED: thimet oligopep (480 aa)
initn: 497 init1: 292 opt: 644 Z-score: 755.0 bits: 149.7 E(85289): 2.6e-35
Smith-Waterman score: 644; 28.6% identity (63.4% similar) in 423 aa overlap (282-694:47-463)
260 270 280 290 300 310
pF1KE6 DGLHAESPDDLVREAAYKIFLYPNAGQLKCLEELLSSRDLLAKLVGYSTFSHRALQGTIA
:.::.. : ..:.:. : . .:. ..:
XP_011 PLLKKCHVPETRRKVEEAFNCRCKEENCAILKELVTLRAQKSRLLGFHTHADYVLEMNMA
20 30 40 50 60 70
320 330 340 350 360
pF1KE6 KNPETVMQFLEKLSDKLS-----ERTLKDFEMIRGMKMKLN-PQNSEVMPWDPPYYSGVI
:. .:: ::..:..::. ::.. .:. :. . . : .... :: :: . .
XP_011 KTSQTVATFLDELAQKLKPLGEQERAVI-LELKRAECERRGLPFDGRIRAWDMRYYMNQV
80 90 100 110 120 130
370 380 390 400 410 420
pF1KE6 RAERYNIEPSLYCPFFSLGACMEGLNILLNRLLGISLYAEQPAKGEVWSEDVRKLAVVHE
. :: .. .: .: . . .:: . ..:::.... :. :.. : :::: ..
XP_011 EETRYCVDQNLLKEYFPVQVVTHGLLGIYQELLGLAFHHEEGASA--WHEDVRLYTARDA
140 150 160 170 180 190
430 440 450 460 470 480
pF1KE6 SEG-LLGYIYCDFFQRADK-PHQDCHFTIRGGRLKEDGDYQLPVVVLMLNLPRSSRSSPT
. : ..: .: :.. : : : : : .. : :..::. :. ..... :. . . ..:.
XP_011 ASGEVVGKFYLDLYPREGKYGHAAC-FGLQPGCLRQDGSRQIAIAAMVANFTKPTADAPS
200 210 220 230 240 250
490 500 510 520 530 540
pF1KE6 LLTPGMMENLFHEMGHAMHSMLGRTRYQHVTGTRCPTDFAEVPSILMEYFANDYRVVNQF
:: .:. :::.::.::.. ..... .::. ::.:.:: ..: .. . . . ..
XP_011 LLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEQEPLLRM
260 270 280 290 300 310
550 560 570 580 590 600
pF1KE6 ARHYQTGQPLPKNMVSRLCESKKVCAAADMQLQVFYATLDQIYHGKHPLRNSTTDILKET
.:::.::. .:.... .: ::... .. :. : .:: : . . . . .
XP_011 SRHYRTGSAVPRELLEKLIESRQANTGLFNLRQIVLAKVDQALHTQTDA-DPAEEYARLC
320 330 340 350 360 370
610 620 630 640 650 660
pF1KE6 QEKFYGLPYVPNTAWQLRFSHLVG-YGARYYSYLMSRAVASMVWKECFLQDP-FNRAAGE
:: . :.: .:.: :.::.: : :.::.:: :.. . ... : :. .: .:
XP_011 QE-ILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGVLNSKVGM
380 390 400 410 420 430
670 680 690 700 710
pF1KE6 RYRREMLAHGGGREPMLMVEGMLQKCPSVDDFVSALVSDLDLDFETFLMDSE
:: .: ::... :.. .: . :. : :.
XP_011 DYRSCILRPGGSEDASAMLRRFLGRDPKQDAFLLSKGLQVGGCEPEPQVC
440 450 460 470 480
>>NP_003240 (OMIM: 601117) thimet oligopeptidase [Homo s (689 aa)
initn: 542 init1: 292 opt: 644 Z-score: 752.8 bits: 149.8 E(85289): 3.4e-35
Smith-Waterman score: 714; 27.5% identity (58.5% similar) in 607 aa overlap (120-694:80-672)
90 100 110 120 130 140
pF1KE6 LLVDRACSTPPGPQTVLIFDELSDSLCRVADLADFVKIAHPEPAFREAAEEACRSIGTMV
.. :: . . : .: :. :: .... .
NP_003 QVGTQEFEDVSYESTLKALADVEVTYTVQRNILDFPQHVSPSKDIRTASTEADKKLSEFD
50 60 70 80 90 100
150 160 170 180 190 200
pF1KE6 EKLNTNVDLYQSLQKLLADKKLVDSLDPETRRVAELFMFDFEISGIHLDKE--------K
... :.:: . : .: ::: ::. : : .. . .:.:: .: :
NP_003 VEMSMREDVYQRIV-WLQEKVQKDSLRPEAARYLERLIKLGRRNGLHLPRETQENIKRIK
110 120 130 140 150 160
210 220 230 240
pF1KE6 RKRA---VDLNVKILDLSSTFL------MG---TNFPNKIEKHLLPEHIRRNFTSAGDHI
.: . .:.: : :. ..::: .: .: :..:: : . . : :
NP_003 KKLSLLCIDFN-KNLNEDTTFLPFTLQELGGLPEDFLNSLEKM---EDGKLKVTLKYPHY
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE6 --IIDGLHAESPDDLVREAAYKIFLYPNAGQLKCLEELLSSRDLLAKLVGYSTFSHRALQ
.. :. :.:: : . :: ::.. : ..:.:. : . .:.
NP_003 FPLLKKCHVPETRRKVEEAFNCRCKEENCAILK---ELVTLRAQKSRLLGFHTHADYVLE
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE6 GTIAKNPETVMQFLEKLSDKLS-----ERTLKDFEMIRGMKMKLN-PQNSEVMPWDPPYY
..::. .:: ::..:..::. ::.. .:. :. . . : .... :: ::
NP_003 MNMAKTSQTVATFLDELAQKLKPLGEQERAVI-LELKRAECERRGLPFDGRIRAWDMRYY
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE6 SGVIRAERYNIEPSLYCPFFSLGACMEGLNILLNRLLGISLYAEQPAKGEVWSEDVRKLA
. .. :: .. .: .: . . .:: . ..:::.... :. :.. : :::: .
NP_003 MNQVEETRYCVDQNLLKEYFPVQVVTHGLLGIYQELLGLAFHHEEGASA--WHEDVRLYT
350 360 370 380 390
430 440 450 460 470
pF1KE6 VVHESEG-LLGYIYCDFFQRADK-PHQDCHFTIRGGRLKEDGDYQLPVVVLMLNLPRSSR
. . : ..: .: :.. : : : : : .. : :..::. :. ..... :. . .
NP_003 ARDAASGEVVGKFYLDLYPREGKYGHAAC-FGLQPGCLRQDGSRQIAIAAMVANFTKPTA
400 410 420 430 440 450
480 490 500 510 520 530
pF1KE6 SSPTLLTPGMMENLFHEMGHAMHSMLGRTRYQHVTGTRCPTDFAEVPSILMEYFANDYRV
..:.:: .:. :::.::.::.. ..... .::. ::.:.:: ..: .. . .
NP_003 DAPSLLQHDEVETYFHEFGHVMHQLCSQAEFAMFSGTHVERDFVEAPSQMLENWVWEQEP
460 470 480 490 500 510
540 550 560 570 580 590
pF1KE6 VNQFARHYQTGQPLPKNMVSRLCESKKVCAAADMQLQVFYATLDQIYHGKHPLRNSTTDI
. ...:::.::. .:.... .: ::... .. :. : .:: : . . . .
NP_003 LLRMSRHYRTGSAVPRELLEKLIESRQANTGLFNLRQIVLAKVDQALHTQTDA-DPAEEY
520 530 540 550 560 570
600 610 620 630 640 650
pF1KE6 LKETQEKFYGLPYVPNTAWQLRFSHLVG-YGARYYSYLMSRAVASMVWKECFLQDP-FNR
. :: . :.: .:.: :.::.: : :.::.:: :.. . ... : :. .:
NP_003 ARLCQE-ILGVPATPGTNMPATFGHLAGGYDAQYYGYLWSEVYSMDMFHTRFKQEGVLNS
580 590 600 610 620 630
660 670 680 690 700 710
pF1KE6 AAGERYRREMLAHGGGREPMLMVEGMLQKCPSVDDFVSALVSDLDLDFETFLMDSE
.: :: .: ::... :.. .: . :. : :.
NP_003 KVGMDYRSCILRPGGSEDASAMLRRFLGRDPKQDAFLLSKGLQVGGCEPEPQVC
640 650 660 670 680
>>XP_006714724 (OMIM: 611530) PREDICTED: neurolysin, mit (681 aa)
initn: 515 init1: 271 opt: 631 Z-score: 737.6 bits: 147.0 E(85289): 2.4e-34
Smith-Waterman score: 659; 26.9% identity (56.0% similar) in 605 aa overlap (121-694:82-673)
100 110 120 130 140 150
pF1KE6 LVDRACSTPPGPQTVLIFDELSDSLCRVADLADFVKIAHPEPAFREAAEEACRSIGTMVE
. :: . . . : :. :: . .. .
XP_006 VGMLGIEEVTYENCLQALADVEVKYIVERTMLDFPQHVSSDKEVRAASTEADKRLSRFDI
60 70 80 90 100 110
160 170 180 190 200
pF1KE6 KLNTNVDLYQSLQKLLADKKLVDSLDPETRRVAELFMFDFEISGIHLD-------KEKRK
... :... . .: : .. ::.:: : . . .:.:: : .:
XP_006 EMSMRGDIFERIVHLQETCDL-GKIKPEARRYLEKSIKMGKRNGLHLPEQVQNEIKSMKK
120 130 140 150 160 170
210 220 230 240 250
pF1KE6 RAVDLNV---KILDLSSTFLMGTNFPNKIEKHLLPEHIRRNFTSAGD---HIIIDGLHAE
: .: . : :. ..:::. : .: : ::. . .. .. : .: . :
XP_006 RMSELCIDFNKNLNEDDTFLV---F-SKAELGALPDDFIDSLEKTDDDKYKITLKYPHYF
180 190 200 210 220
260 270 280 290 300
pF1KE6 S--PDDLVREAAYKIFLYPNAGQLKCLEE-------LLSSRDLLAKLVGYSTFSHRALQG
. :. .. . :. .: :: :: : .:::.:::: . .:.
XP_006 PVMKKCCIPETRRRMEMAFNT---RCKEENTIILQQLLPLRTKVAKLLGYSTHADFVLEM
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE6 TIAKNPETVMQFLEKLSDKLSERTLKDFEMIRGMKMKLNPQ-----NSEVMPWDPPYYSG
. ::. : ::. ::.::. . :.: ..: : . .... :: ::
XP_006 NTAKSTSRVTAFLDDLSQKLKPLGEAEREFILNLKKKECKDRGFEYDGKINAWDLYYYMT
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE6 VIRAERYNIEPSLYCPFFSLGACMEGLNILLNRLLGISLYAEQPAKGEVWSEDVRKLAVV
. .:.:. . .: . . ::: ..:::.:. :: . ..::...: .:
XP_006 QTEELKYSIDQEFLKEYFPIEVVTEGLLNTYQELLGLSF--EQMTDAHVWNKSVTLYTVK
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE6 HESEG-LLGYIYCDFFQRADK-PHQDCHFTIRGGRLKEDGDYQLPVVVLMLNLPRSSRSS
.. : .:: .: :.. : : : : : .. : : ::. .. :..:..:. . .
XP_006 DKATGEVLGQFYLDLYPREGKYNHAAC-FGLQPGCLLPDGSRMMAVAALVVNFSQPVAGR
410 420 430 440 450 460
490 500 510 520 530 540
pF1KE6 PTLLTPGMMENLFHEMGHAMHSMLGRTRYQHVTGTRCPTDFAEVPSILMEYFANDYRVVN
:.:: ... :::.::.::.. ..: . . .:: :::.:::: ..: .. : .
XP_006 PSLLRHDEVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWDVDSLR
470 480 490 500 510 520
550 560 570 580 590 600
pF1KE6 QFARHYQTGQPLPKNMVSRLCESKKVCAAADMQLQVFYATLDQIYHGKHPLRNSTTDILK
....::. :.:. ... .: :. : .. :. . .:: : . : ..... :
XP_006 RLSKHYKDGSPIADDLLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNTSL-DAASEYAK
530 540 550 560 570
610 620 630 640 650
pF1KE6 ETQEKFYGLPYVPNTAWQLRFSHLVG-YGARYYSYLMSRAVASMVWKECFLQDPF-NRAA
.: . :. .:.: :.::.: : ..::.:: :.. . .. :: .. . : .
XP_006 YCSE-ILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSEVFSMDMFYSCFKKEGIMNPEV
580 590 600 610 620 630
660 670 680 690 700 710
pF1KE6 GERYRREMLAHGGGREPMLMVEGMLQKCPSVDDFVSALVSDLDLDFETFLMDSE
: .:: .: ::. . : :....:.. :. :.
XP_006 GMKYRNLILKPGGSLDGMDMLHNFLKREPNQKAFLMSRGLHAP
640 650 660 670 680
>>NP_065777 (OMIM: 611530) neurolysin, mitochondrial [Ho (704 aa)
initn: 515 init1: 271 opt: 631 Z-score: 737.4 bits: 147.0 E(85289): 2.5e-34
Smith-Waterman score: 659; 26.9% identity (56.0% similar) in 605 aa overlap (121-694:105-696)
100 110 120 130 140 150
pF1KE6 LVDRACSTPPGPQTVLIFDELSDSLCRVADLADFVKIAHPEPAFREAAEEACRSIGTMVE
. :: . . . : :. :: . .. .
NP_065 VGMLGIEEVTYENCLQALADVEVKYIVERTMLDFPQHVSSDKEVRAASTEADKRLSRFDI
80 90 100 110 120 130
160 170 180 190 200
pF1KE6 KLNTNVDLYQSLQKLLADKKLVDSLDPETRRVAELFMFDFEISGIHLD-------KEKRK
... :... . .: : .. ::.:: : . . .:.:: : .:
NP_065 EMSMRGDIFERIVHLQETCDL-GKIKPEARRYLEKSIKMGKRNGLHLPEQVQNEIKSMKK
140 150 160 170 180 190
210 220 230 240 250
pF1KE6 RAVDLNV---KILDLSSTFLMGTNFPNKIEKHLLPEHIRRNFTSAGD---HIIIDGLHAE
: .: . : :. ..:::. : .: : ::. . .. .. : .: . :
NP_065 RMSELCIDFNKNLNEDDTFLV---F-SKAELGALPDDFIDSLEKTDDDKYKITLKYPHYF
200 210 220 230 240
260 270 280 290 300
pF1KE6 S--PDDLVREAAYKIFLYPNAGQLKCLEE-------LLSSRDLLAKLVGYSTFSHRALQG
. :. .. . :. .: :: :: : .:::.:::: . .:.
NP_065 PVMKKCCIPETRRRMEMAFNT---RCKEENTIILQQLLPLRTKVAKLLGYSTHADFVLEM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 TIAKNPETVMQFLEKLSDKLSERTLKDFEMIRGMKMKLNPQ-----NSEVMPWDPPYYSG
. ::. : ::. ::.::. . :.: ..: : . .... :: ::
NP_065 NTAKSTSRVTAFLDDLSQKLKPLGEAEREFILNLKKKECKDRGFEYDGKINAWDLYYYMT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 VIRAERYNIEPSLYCPFFSLGACMEGLNILLNRLLGISLYAEQPAKGEVWSEDVRKLAVV
. .:.:. . .: . . ::: ..:::.:. :: . ..::...: .:
NP_065 QTEELKYSIDQEFLKEYFPIEVVTEGLLNTYQELLGLSF--EQMTDAHVWNKSVTLYTVK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 HESEG-LLGYIYCDFFQRADK-PHQDCHFTIRGGRLKEDGDYQLPVVVLMLNLPRSSRSS
.. : .:: .: :.. : : : : : .. : : ::. .. :..:..:. . .
NP_065 DKATGEVLGQFYLDLYPREGKYNHAAC-FGLQPGCLLPDGSRMMAVAALVVNFSQPVAGR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 PTLLTPGMMENLFHEMGHAMHSMLGRTRYQHVTGTRCPTDFAEVPSILMEYFANDYRVVN
:.:: ... :::.::.::.. ..: . . .:: :::.:::: ..: .. : .
NP_065 PSLLRHDEVRTYFHEFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWDVDSLR
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE6 QFARHYQTGQPLPKNMVSRLCESKKVCAAADMQLQVFYATLDQIYHGKHPLRNSTTDILK
....::. :.:. ... .: :. : .. :. . .:: : . : ..... :
NP_065 RLSKHYKDGSPIADDLLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNTSL-DAASEYAK
550 560 570 580 590 600
610 620 630 640 650
pF1KE6 ETQEKFYGLPYVPNTAWQLRFSHLVG-YGARYYSYLMSRAVASMVWKECFLQDPF-NRAA
.: . :. .:.: :.::.: : ..::.:: :.. . .. :: .. . : .
NP_065 YCSE-ILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSEVFSMDMFYSCFKKEGIMNPEV
610 620 630 640 650 660
660 670 680 690 700 710
pF1KE6 GERYRREMLAHGGGREPMLMVEGMLQKCPSVDDFVSALVSDLDLDFETFLMDSE
: .:: .: ::. . : :....:.. :. :.
NP_065 GMKYRNLILKPGGSLDGMDMLHNFLKREPNQKAFLMSRGLHAP
670 680 690 700
>>XP_016865162 (OMIM: 611530) PREDICTED: neurolysin, mit (663 aa)
initn: 396 init1: 152 opt: 288 Z-score: 335.5 bits: 72.5 E(85289): 6e-12
Smith-Waterman score: 560; 26.0% identity (53.9% similar) in 605 aa overlap (121-694:82-655)
100 110 120 130 140 150
pF1KE6 LVDRACSTPPGPQTVLIFDELSDSLCRVADLADFVKIAHPEPAFREAAEEACRSIGTMVE
. :: . . . : :. :: . .. .
XP_016 VGMLGIEEVTYENCLQALADVEVKYIVERTMLDFPQHVSSDKEVRAASTEADKRLSRFDI
60 70 80 90 100 110
160 170 180 190 200
pF1KE6 KLNTNVDLYQSLQKLLADKKLVDSLDPETRRVAELFMFDFEISGIHLD-------KEKRK
... :... . .: : .. ::.:: : . . .:.:: : .:
XP_016 EMSMRGDIFERIVHLQETCDL-GKIKPEARRYLEKSIKMGKRNGLHLPEQVQNEIKSMKK
120 130 140 150 160 170
210 220 230 240 250
pF1KE6 RAVDLNV---KILDLSSTFLMGTNFPNKIEKHLLPEHIRRNFTSAGD---HIIIDGLHAE
: .: . : :. ..:::. : .: : ::. . .. .. : .: . :
XP_016 RMSELCIDFNKNLNEDDTFLV---F-SKAELGALPDDFIDSLEKTDDDKYKITLKYPHYF
180 190 200 210 220
260 270 280 290 300
pF1KE6 S--PDDLVREAAYKIFLYPNAGQLKCLEE-------LLSSRDLLAKLVGYSTFSHRALQG
. :. .. . :. .: :: :: : .:::.:::: . .:.
XP_016 PVMKKCCIPETRRRMEMAFNT---RCKEENTIILQQLLPLRTKVAKLLGYSTHADFVLEM
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE6 TIAKNPETVMQFLEKLSDKLSERTLKDFEMIRGMKMKLNPQ-----NSEVMPWDPPYYSG
. ::. : ::. ::.::. . :.: ..: : . .... :: ::
XP_016 NTAKSTSRVTAFLDDLSQKLKPLGEAEREFILNLKKKECKDRGFEYDGKINAWDLYYYMT
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE6 VIRAERYNIEPSLYCPFFSLGACMEGLNILLNRLLGISLYAEQPAKGEVWSEDVRKLAVV
. .:.:. . .: . . ::: ..:::.:. :: . ..::...: .:
XP_016 QTEELKYSIDQEFLKEYFPIEVVTEGLLNTYQELLGLSF--EQMTDAHVWNKSVTLYTVK
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE6 HESEG-LLGYIYCDFFQRADK-PHQDCHFTIRGGRLKEDGDYQLPVVVLMLNLPRSSRSS
.. : .:: .: :.. : : : : : .. : : ::. .. :..:..:. . .
XP_016 DKATGEVLGQFYLDLYPREGKYNHAAC-FGLQPGCLLPDGSRMMAVAALVVNFSQPVAGR
410 420 430 440 450 460
490 500 510 520 530 540
pF1KE6 PTLLTPGMMENLFHEMGHAMHSMLGRTRYQHVTGTRCPTDFAEVPSILMEYFANDYRVVN
:.:: :. .: . . .:: :::.:::: ..: .. : .
XP_016 PSLLR--------HD----------ETDFARFSGTNVETDFVEVPSQMLENWVWDVDSLR
470 480 490 500
550 560 570 580 590 600
pF1KE6 QFARHYQTGQPLPKNMVSRLCESKKVCAAADMQLQVFYATLDQIYHGKHPLRNSTTDILK
....::. :.:. ... .: :. : .. :. . .:: : . : ..... :
XP_016 RLSKHYKDGSPIADDLLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNTSL-DAASEYAK
510 520 530 540 550 560
610 620 630 640 650
pF1KE6 ETQEKFYGLPYVPNTAWQLRFSHLVG-YGARYYSYLMSRAVASMVWKECFLQDPF-NRAA
.: . :. .:.: :.::.: : ..::.:: :.. . .. :: .. . : .
XP_016 YCSE-ILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSEVFSMDMFYSCFKKEGIMNPEV
570 580 590 600 610 620
660 670 680 690 700 710
pF1KE6 GERYRREMLAHGGGREPMLMVEGMLQKCPSVDDFVSALVSDLDLDFETFLMDSE
: .:: .: ::. . : :....:.. :. :.
XP_016 GMKYRNLILKPGGSLDGMDMLHNFLKREPNQKAFLMSRGLHAP
630 640 650 660
>>XP_005248616 (OMIM: 611530) PREDICTED: neurolysin, mit (686 aa)
initn: 396 init1: 152 opt: 288 Z-score: 335.3 bits: 72.5 E(85289): 6.2e-12
Smith-Waterman score: 560; 26.0% identity (53.9% similar) in 605 aa overlap (121-694:105-678)
100 110 120 130 140 150
pF1KE6 LVDRACSTPPGPQTVLIFDELSDSLCRVADLADFVKIAHPEPAFREAAEEACRSIGTMVE
. :: . . . : :. :: . .. .
XP_005 VGMLGIEEVTYENCLQALADVEVKYIVERTMLDFPQHVSSDKEVRAASTEADKRLSRFDI
80 90 100 110 120 130
160 170 180 190 200
pF1KE6 KLNTNVDLYQSLQKLLADKKLVDSLDPETRRVAELFMFDFEISGIHLD-------KEKRK
... :... . .: : .. ::.:: : . . .:.:: : .:
XP_005 EMSMRGDIFERIVHLQETCDL-GKIKPEARRYLEKSIKMGKRNGLHLPEQVQNEIKSMKK
140 150 160 170 180 190
210 220 230 240 250
pF1KE6 RAVDLNV---KILDLSSTFLMGTNFPNKIEKHLLPEHIRRNFTSAGD---HIIIDGLHAE
: .: . : :. ..:::. : .: : ::. . .. .. : .: . :
XP_005 RMSELCIDFNKNLNEDDTFLV---F-SKAELGALPDDFIDSLEKTDDDKYKITLKYPHYF
200 210 220 230 240
260 270 280 290 300
pF1KE6 S--PDDLVREAAYKIFLYPNAGQLKCLEE-------LLSSRDLLAKLVGYSTFSHRALQG
. :. .. . :. .: :: :: : .:::.:::: . .:.
XP_005 PVMKKCCIPETRRRMEMAFNT---RCKEENTIILQQLLPLRTKVAKLLGYSTHADFVLEM
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 TIAKNPETVMQFLEKLSDKLSERTLKDFEMIRGMKMKLNPQ-----NSEVMPWDPPYYSG
. ::. : ::. ::.::. . :.: ..: : . .... :: ::
XP_005 NTAKSTSRVTAFLDDLSQKLKPLGEAEREFILNLKKKECKDRGFEYDGKINAWDLYYYMT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 VIRAERYNIEPSLYCPFFSLGACMEGLNILLNRLLGISLYAEQPAKGEVWSEDVRKLAVV
. .:.:. . .: . . ::: ..:::.:. :: . ..::...: .:
XP_005 QTEELKYSIDQEFLKEYFPIEVVTEGLLNTYQELLGLSF--EQMTDAHVWNKSVTLYTVK
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 HESEG-LLGYIYCDFFQRADK-PHQDCHFTIRGGRLKEDGDYQLPVVVLMLNLPRSSRSS
.. : .:: .: :.. : : : : : .. : : ::. .. :..:..:. . .
XP_005 DKATGEVLGQFYLDLYPREGKYNHAAC-FGLQPGCLLPDGSRMMAVAALVVNFSQPVAGR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 PTLLTPGMMENLFHEMGHAMHSMLGRTRYQHVTGTRCPTDFAEVPSILMEYFANDYRVVN
:.:: :. .: . . .:: :::.:::: ..: .. : .
XP_005 PSLLR--------HD----------ETDFARFSGTNVETDFVEVPSQMLENWVWDVDSLR
490 500 510 520
550 560 570 580 590 600
pF1KE6 QFARHYQTGQPLPKNMVSRLCESKKVCAAADMQLQVFYATLDQIYHGKHPLRNSTTDILK
....::. :.:. ... .: :. : .. :. . .:: : . : ..... :
XP_005 RLSKHYKDGSPIADDLLEKLVASRLVNTGLLTLRQIVLSKVDQSLHTNTSL-DAASEYAK
530 540 550 560 570 580
610 620 630 640 650
pF1KE6 ETQEKFYGLPYVPNTAWQLRFSHLVG-YGARYYSYLMSRAVASMVWKECFLQDPF-NRAA
.: . :. .:.: :.::.: : ..::.:: :.. . .. :: .. . : .
XP_005 YCSE-ILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSEVFSMDMFYSCFKKEGIMNPEV
590 600 610 620 630 640
660 670 680 690 700 710
pF1KE6 GERYRREMLAHGGGREPMLMVEGMLQKCPSVDDFVSALVSDLDLDFETFLMDSE
: .:: .: ::. . : :....:.. :. :.
XP_005 GMKYRNLILKPGGSLDGMDMLHNFLKREPNQKAFLMSRGLHAP
650 660 670 680
713 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 15:35:17 2016 done: Tue Nov 8 15:35:18 2016
Total Scan time: 6.080 Total Display time: 0.100
Function used was FASTA [36.3.4 Apr, 2011]