Result of FASTA (omim) for
pFN21AE6708
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6708, 739 aa
1>>>pF1KE6708 739 - 739 aa - 739 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.7075+/-0.000436; mu= 5.3678+/- 0.027
mean_var=245.5380+/-49.259, 0's: 0 Z-trim(119.6): 24 B-trim: 64 in 1/54
Lambda= 0.081849
statistics sampled from 33808 (33832) to 33808 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.728), E-opt: 0.2 (0.397), width: 16
Scan time: 11.770
The best scores are: opt bits E(85289)
NP_036450 (OMIM: 194190,604407) LETM1 and EF-hand ( 739) 4771 577.2 8.3e-164
XP_006713947 (OMIM: 194190,604407) PREDICTED: LETM ( 738) 4753 575.1 3.6e-163
XP_016863676 (OMIM: 194190,604407) PREDICTED: LETM ( 559) 3493 426.2 1.8e-118
>>NP_036450 (OMIM: 194190,604407) LETM1 and EF-hand doma (739 aa)
initn: 4771 init1: 4771 opt: 4771 Z-score: 3061.8 bits: 577.2 E(85289): 8.3e-164
Smith-Waterman score: 4771; 100.0% identity (100.0% similar) in 739 aa overlap (1-739:1-739)
10 20 30 40 50 60
pF1KE6 MASILLRSCRGRAPARLPPPPRYTVPRGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 MASILLRSCRGRAPARLPPPPRYTVPRGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 VYTSSRGDHLGCWALRPECLRIVSRAPWTSTSVGFVAVGPQCLPVRGWHSSRPVRDDSVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 VYTSSRGDHLGCWALRPECLRIVSRAPWTSTSVGFVAVGPQCLPVRGWHSSRPVRDDSVV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 EKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDTKIAAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 EKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDTKIAAR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 MLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 MLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 ETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 ETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 SNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 SNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 LIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 LIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 MYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 MYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 REKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 REKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE6 TKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 TKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE6 ESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 ESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE6 KHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_036 KHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKV
670 680 690 700 710 720
730
pF1KE6 EEKEKAKEKAEKEVAEVKS
:::::::::::::::::::
NP_036 EEKEKAKEKAEKEVAEVKS
730
>>XP_006713947 (OMIM: 194190,604407) PREDICTED: LETM1 an (738 aa)
initn: 4751 init1: 3251 opt: 4753 Z-score: 3050.3 bits: 575.1 E(85289): 3.6e-163
Smith-Waterman score: 4753; 99.9% identity (99.9% similar) in 739 aa overlap (1-739:1-738)
10 20 30 40 50 60
pF1KE6 MASILLRSCRGRAPARLPPPPRYTVPRGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MASILLRSCRGRAPARLPPPPRYTVPRGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 VYTSSRGDHLGCWALRPECLRIVSRAPWTSTSVGFVAVGPQCLPVRGWHSSRPVRDDSVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VYTSSRGDHLGCWALRPECLRIVSRAPWTSTSVGFVAVGPQCLPVRGWHSSRPVRDDSVV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 EKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDTKIAAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDTKIAAR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 MLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 ETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 SNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 LIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 MYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEH
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 REKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEI
:::::::::::: :::::::::::::::::::::::::::::::::::::::::::::::
XP_006 REKELQKRSEVA-DFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEI
490 500 510 520 530
550 560 570 580 590 600
pF1KE6 TKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVE
540 550 560 570 580 590
610 620 630 640 650 660
pF1KE6 ESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQV
600 610 620 630 640 650
670 680 690 700 710 720
pF1KE6 KHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKV
660 670 680 690 700 710
730
pF1KE6 EEKEKAKEKAEKEVAEVKS
:::::::::::::::::::
XP_006 EEKEKAKEKAEKEVAEVKS
720 730
>>XP_016863676 (OMIM: 194190,604407) PREDICTED: LETM1 an (559 aa)
initn: 3493 init1: 3493 opt: 3493 Z-score: 2247.8 bits: 426.2 E(85289): 1.8e-118
Smith-Waterman score: 3493; 100.0% identity (100.0% similar) in 559 aa overlap (181-739:1-559)
160 170 180 190 200 210
pF1KE6 KSLGQRVLDELKHYYHGFRLLWIDTKIAARMLWRILNGHSLTRRERRQFLRICADLFRLV
::::::::::::::::::::::::::::::
XP_016 MLWRILNGHSLTRRERRQFLRICADLFRLV
10 20 30
220 230 240 250 260 270
pF1KE6 PFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQDTIEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFLVFVVVPFMEFLLPVAVKLFPNMLPSTFETQSLKEERLKKELRVKLELAKFLQDTIEE
40 50 60 70 80 90
280 290 300 310 320 330
pF1KE6 MALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MALKNKAAKGSATKDFSVFFQKIRETGERPSNEEIMRFSKLFEDELTLDNLTRPQLVALC
100 110 120 130 140 150
340 350 360 370 380 390
pF1KE6 KLLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLLELQSIGTNNFLRFQLTMRLRSIKADDKLIAEEGVDSLNVKELQAACRARGMRALGVT
160 170 180 190 200 210
400 410 420 430 440 450
pF1KE6 EDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDRLRGQLKQWLDLHLHQEIPTSLLILSRAMYLPDTLSPADQLKSTLQTLPEIVAKEAQV
220 230 240 250 260 270
460 470 480 490 500 510
pF1KE6 KVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVAEVEGEQVDNKAKLEATLQEEAAIQQEHREKELQKRSEVAKDFEPERVVAAPQRPGTE
280 290 300 310 320 330
520 530 540 550 560 570
pF1KE6 PQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQPEMPDTVLQSETLKDTAPVLEGLKEEEITKEEIDILSDACSKLQEQKKSLTKEKEELE
340 350 360 370 380 390
580 590 600 610 620 630
pF1KE6 LLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLKEDVQDYSEDLQEIKKELSKTGEEKYVEESKASKRLTKRVQQMIGQIDGLISQLEMDQ
400 410 420 430 440 450
640 650 660 670 680 690
pF1KE6 QAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QAGKLAPANGMPTGENVISVAELINAMKQVKHIPESKLTSLAAALDENKDGKVNIDDLVK
460 470 480 490 500 510
700 710 720 730
pF1KE6 VIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVAEVKS
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VIELVDKEDVHISTSQVAEIVATLEKEEKVEEKEKAKEKAEKEVAEVKS
520 530 540 550
739 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 15:34:35 2016 done: Tue Nov 8 15:34:36 2016
Total Scan time: 11.770 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]