Result of FASTA (omim) for
pFN21AE6702
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6702, 758 aa
1>>>pF1KE6702 758 - 758 aa - 758 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5169+/-0.000445; mu= 19.4573+/- 0.028
mean_var=81.5762+/-16.529, 0's: 0 Z-trim(111.1): 55 B-trim: 0 in 0/51
Lambda= 0.142001
statistics sampled from 19552 (19601) to 19552 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.589), E-opt: 0.2 (0.23), width: 16
Scan time: 9.530
The best scores are: opt bits E(85289)
NP_599025 (OMIM: 610068) solute carrier family 26 ( 758) 4887 1011.8 0
NP_075062 (OMIM: 610068) solute carrier family 26 ( 759) 4875 1009.3 0
NP_001035544 (OMIM: 610068) solute carrier family ( 738) 4745 982.7 0
NP_602298 (OMIM: 610068) solute carrier family 26 ( 740) 3879 805.3 0
NP_001268662 (OMIM: 610068) solute carrier family ( 651) 3249 676.2 1.2e-193
NP_001268661 (OMIM: 610068) solute carrier family ( 723) 3222 670.7 6e-192
NP_996766 (OMIM: 604943,613865) prestin isoform b ( 685) 1769 373.0 2.3e-102
XP_011514472 (OMIM: 604943,613865) PREDICTED: pres ( 744) 1769 373.0 2.5e-102
NP_945350 (OMIM: 604943,613865) prestin isoform a ( 744) 1769 373.0 2.5e-102
NP_443166 (OMIM: 608481) solute carrier family 26 ( 791) 1726 364.2 1.2e-99
NP_599152 (OMIM: 608481) solute carrier family 26 ( 887) 1726 364.3 1.3e-99
XP_011507423 (OMIM: 608481) PREDICTED: solute carr ( 702) 1544 326.9 1.8e-88
NP_996767 (OMIM: 604943,613865) prestin isoform c ( 516) 1536 325.2 4.4e-88
XP_011507424 (OMIM: 608481) PREDICTED: solute carr ( 627) 1342 285.5 4.7e-76
NP_001308716 (OMIM: 604943,613865) prestin isoform ( 653) 1291 275.0 6.8e-73
NP_001161434 (OMIM: 604943,613865) prestin isoform ( 712) 1291 275.1 7.2e-73
NP_000432 (OMIM: 274600,600791,605646) pendrin [Ho ( 780) 1261 268.9 5.5e-71
XP_005250482 (OMIM: 274600,600791,605646) PREDICTE ( 780) 1261 268.9 5.5e-71
XP_011507426 (OMIM: 608481) PREDICTED: solute carr ( 466) 1247 265.9 2.7e-70
NP_000102 (OMIM: 126650,214700) chloride anion exc ( 764) 1212 258.9 5.7e-68
XP_011514169 (OMIM: 126650,214700) PREDICTED: chlo ( 764) 1212 258.9 5.7e-68
NP_439897 (OMIM: 608479) anion exchange transporte ( 656) 1047 225.1 7.6e-58
NP_001269285 (OMIM: 608479) anion exchange transpo ( 656) 1047 225.1 7.6e-58
NP_599028 (OMIM: 608479) anion exchange transporte ( 663) 1047 225.1 7.6e-58
NP_071325 (OMIM: 167030,610130) sulfate anion tran ( 701) 990 213.4 2.6e-54
NP_998778 (OMIM: 167030,610130) sulfate anion tran ( 701) 990 213.4 2.6e-54
XP_016864680 (OMIM: 222600,226900,256050,600972,60 ( 739) 979 211.2 1.3e-53
NP_000103 (OMIM: 222600,226900,256050,600972,60671 ( 739) 979 211.2 1.3e-53
NP_443193 (OMIM: 606766,608480) testis anion trans ( 970) 879 190.8 2.4e-47
XP_016865724 (OMIM: 606766,608480) PREDICTED: test ( 970) 879 190.8 2.4e-47
NP_001180405 (OMIM: 606766,608480) testis anion tr ( 970) 879 190.8 2.4e-47
NP_996768 (OMIM: 604943,613865) prestin isoform d ( 335) 855 185.5 3.1e-46
XP_016867807 (OMIM: 274600,600791,605646) PREDICTE ( 754) 792 172.9 4.5e-42
XP_006716088 (OMIM: 274600,600791,605646) PREDICTE ( 423) 783 170.8 1e-41
NP_619732 (OMIM: 606766,608480) testis anion trans ( 865) 648 143.4 3.8e-33
NP_775897 (OMIM: 610117) sodium-independent sulfat ( 606) 585 130.4 2.2e-29
NP_001159819 (OMIM: 610117) sodium-independent sul ( 606) 585 130.4 2.2e-29
NP_001159820 (OMIM: 610117) sodium-independent sul ( 606) 585 130.4 2.2e-29
NP_001159821 (OMIM: 610117) sodium-independent sul ( 606) 585 130.4 2.2e-29
NP_001269286 (OMIM: 608479) anion exchange transpo ( 355) 448 102.1 4.1e-21
XP_006721896 (OMIM: 610117) PREDICTED: sodium-inde ( 630) 445 101.7 9.8e-21
XP_016879996 (OMIM: 610117) PREDICTED: sodium-inde ( 630) 445 101.7 9.8e-21
XP_016879995 (OMIM: 610117) PREDICTED: sodium-inde ( 677) 445 101.7 1e-20
XP_016879994 (OMIM: 610117) PREDICTED: sodium-inde ( 696) 445 101.7 1.1e-20
NP_602297 (OMIM: 167030,610130) sulfate anion tran ( 224) 343 80.5 8.5e-15
XP_011522955 (OMIM: 610117) PREDICTED: sodium-inde ( 441) 336 79.3 3.9e-14
XP_011522956 (OMIM: 610117) PREDICTED: sodium-inde ( 441) 336 79.3 3.9e-14
XP_011522954 (OMIM: 610117) PREDICTED: sodium-inde ( 465) 336 79.3 4.1e-14
XP_011512596 (OMIM: 606766,608480) PREDICTED: test ( 944) 324 77.1 3.9e-13
>>NP_599025 (OMIM: 610068) solute carrier family 26 memb (758 aa)
initn: 4887 init1: 4887 opt: 4887 Z-score: 5410.2 bits: 1011.8 E(85289): 0
Smith-Waterman score: 4887; 100.0% identity (100.0% similar) in 758 aa overlap (1-758:1-758)
10 20 30 40 50 60
pF1KE6 MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 FGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 FGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAAR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 VQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 VQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 SHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 SHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 TLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 TLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 SLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 SLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 ISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 ISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 FTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 FTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE6 KVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 KVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE6 AASPKGASVSINVNTSLEDMRSNNVEDCKMMVSSGDKMEDATANGQEDSKAPDGSTLKAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 AASPKGASVSINVNTSLEDMRSNNVEDCKMMVSSGDKMEDATANGQEDSKAPDGSTLKAL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE6 GLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_599 GLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHF
670 680 690 700 710 720
730 740 750
pF1KE6 FDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
::::::::::::::::::::::::::::::::::::::
NP_599 FDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
730 740 750
>>NP_075062 (OMIM: 610068) solute carrier family 26 memb (759 aa)
initn: 4048 init1: 4048 opt: 4875 Z-score: 5396.9 bits: 1009.3 E(85289): 0
Smith-Waterman score: 4875; 99.9% identity (99.9% similar) in 759 aa overlap (1-758:1-759)
10 20 30 40 50 60
pF1KE6 MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_075 MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_075 QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 FGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_075 FGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAAR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 VQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_075 VQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 SHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_075 SHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 TLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_075 TLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 SLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_075 SLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 ISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_075 ISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 FTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_075 FTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE6 KVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_075 KVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQ
550 560 570 580 590 600
610 620 630 640 650
pF1KE6 AASPKGASVSINVNTSLEDMRSNNVEDCKMM-VSSGDKMEDATANGQEDSKAPDGSTLKA
::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::
NP_075 AASPKGASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQEDSKAPDGSTLKA
610 620 630 640 650 660
660 670 680 690 700 710
pF1KE6 LGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_075 LGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGH
670 680 690 700 710 720
720 730 740 750
pF1KE6 FFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
:::::::::::::::::::::::::::::::::::::::
NP_075 FFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
730 740 750
>>NP_001035544 (OMIM: 610068) solute carrier family 26 m (738 aa)
initn: 3918 init1: 3918 opt: 4745 Z-score: 5253.2 bits: 982.7 E(85289): 0
Smith-Waterman score: 4745; 99.9% identity (99.9% similar) in 738 aa overlap (22-758:1-738)
10 20 30 40 50 60
pF1KE6 MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL
:::::::::::::::::::::::::::::::::::::::
NP_001 MDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL
10 20 30
70 80 90 100 110 120
pF1KE6 QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE6 FGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAAR
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE6 VQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLS
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE6 SHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELL
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE6 TLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAI
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE6 SLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGA
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE6 ISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVT
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE6 FTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGV
460 470 480 490 500 510
550 560 570 580 590 600
pF1KE6 KVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQ
520 530 540 550 560 570
610 620 630 640 650
pF1KE6 AASPKGASVSINVNTSLEDMRSNNVEDCKMM-VSSGDKMEDATANGQEDSKAPDGSTLKA
::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::
NP_001 AASPKGASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQEDSKAPDGSTLKA
580 590 600 610 620 630
660 670 680 690 700 710
pF1KE6 LGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGH
640 650 660 670 680 690
720 730 740 750
pF1KE6 FFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
:::::::::::::::::::::::::::::::::::::::
NP_001 FFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
700 710 720 730
>>NP_602298 (OMIM: 610068) solute carrier family 26 memb (740 aa)
initn: 4681 init1: 3856 opt: 3879 Z-score: 4294.3 bits: 805.3 E(85289): 0
Smith-Waterman score: 4646; 96.2% identity (97.0% similar) in 758 aa overlap (1-758:1-740)
10 20 30 40 50 60
pF1KE6 MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_602 MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_602 QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 FGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_602 FGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAAR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 VQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_602 VQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 SHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_602 SHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 TLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_602 TLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAI
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 SLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_602 SLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGA
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 ISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_602 ISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 FTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_602 FTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGV
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE6 KVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_602 KVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE6 AASPKGASVSINVNTSLEDMRSNNVEDCKMMVSSGDKMEDATANGQEDSKAPDGSTLKAL
:. .: .. ..:::::::::::::::::::::::::::::
NP_602 AGPLLSACLA------------------PQQVSSGDKMEDATANGQEDSKAPDGSTLKAL
610 620 630 640
670 680 690 700 710 720
pF1KE6 GLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_602 GLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHF
650 660 670 680 690 700
730 740 750
pF1KE6 FDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
::::::::::::::::::::::::::::::::::::::
NP_602 FDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
710 720 730 740
>>NP_001268662 (OMIM: 610068) solute carrier family 26 m (651 aa)
initn: 3239 init1: 3239 opt: 3249 Z-score: 3597.6 bits: 676.2 E(85289): 1.2e-193
Smith-Waterman score: 4005; 85.9% identity (85.9% similar) in 758 aa overlap (1-758:1-651)
10 20 30 40 50 60
pF1KE6 MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 FGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALNDSMINETARDAAR
::::::::::::::::::::::::
NP_001 FGLYSSFYPVFIYFLFGTSRHISV------------------------------------
130 140
190 200 210 220 230 240
pF1KE6 VQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLS
NP_001 ------------------------------------------------------------
250 260 270 280 290 300
pF1KE6 SHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELL
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 -----------VLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELL
150 160 170 180 190
310 320 330 340 350 360
pF1KE6 TLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAI
200 210 220 230 240 250
370 380 390 400 410 420
pF1KE6 SLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGA
260 270 280 290 300 310
430 440 450 460 470 480
pF1KE6 ISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVT
320 330 340 350 360 370
490 500 510 520 530 540
pF1KE6 FTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGV
380 390 400 410 420 430
550 560 570 580 590 600
pF1KE6 KVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQ
440 450 460 470 480 490
610 620 630 640 650 660
pF1KE6 AASPKGASVSINVNTSLEDMRSNNVEDCKMMVSSGDKMEDATANGQEDSKAPDGSTLKAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AASPKGASVSINVNTSLEDMRSNNVEDCKMMVSSGDKMEDATANGQEDSKAPDGSTLKAL
500 510 520 530 540 550
670 680 690 700 710 720
pF1KE6 GLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHF
560 570 580 590 600 610
730 740 750
pF1KE6 FDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
::::::::::::::::::::::::::::::::::::::
NP_001 FDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
620 630 640 650
>>NP_001268661 (OMIM: 610068) solute carrier family 26 m (723 aa)
initn: 3378 init1: 2394 opt: 3222 Z-score: 3567.0 bits: 670.7 E(85289): 6e-192
Smith-Waterman score: 4128; 87.3% identity (90.7% similar) in 761 aa overlap (1-758:1-723)
10 20 30 40 50 60
pF1KE6 MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPV
70 80 90 100 110 120
130 140 150 160 170
pF1KE6 FGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMV--GSVTESLAPQALNDSMINETARDA
::::::::::::::::::::::::.: . . ... : : . .:. : :
NP_001 FGLYSSFYPVFIYFLFGTSRHISVATPGPLPLLTAPGRPTGGAGPDPL---------RLR
130 140 150 160 170
180 190 200 210 220 230
pF1KE6 ARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLH
... : .. : : : . : .: : :. . . ...
NP_001 GHLPVRTSCPRL------------------YHSCSCA-GLRLTAQVCVWPPSEQPLWA--
180 190 200 210
240 250 260 270 280 290
pF1KE6 LSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGE
.. . .::::::::::::::::::::::::::::::::::::::::::::::
NP_001 --------TVPHLLLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGE
220 230 240 250 260
300 310 320 330 340 350
pF1KE6 LLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAI
270 280 290 300 310 320
360 370 380 390 400 410
pF1KE6 AISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVA
330 340 350 360 370 380
420 430 440 450 460 470
pF1KE6 GAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWL
390 400 410 420 430 440
480 490 500 510 520 530
pF1KE6 VTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVR
450 460 470 480 490 500
540 550 560 570 580 590
pF1KE6 GVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLR
510 520 530 540 550 560
600 610 620 630 640 650
pF1KE6 KQAASPKGASVSINVNTSLEDMRSNNVEDCKMM-VSSGDKMEDATANGQEDSKAPDGSTL
::::::::::::::::::::::::::::::::: ::::::::::::::::::::::::::
NP_001 KQAASPKGASVSINVNTSLEDMRSNNVEDCKMMQVSSGDKMEDATANGQEDSKAPDGSTL
570 580 590 600 610 620
660 670 680 690 700 710
pF1KE6 KALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEA
630 640 650 660 670 680
720 730 740 750
pF1KE6 GHFFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
:::::::::::::::::::::::::::::::::::::::::
NP_001 GHFFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
690 700 710 720
>>NP_996766 (OMIM: 604943,613865) prestin isoform b [Hom (685 aa)
initn: 1731 init1: 1330 opt: 1769 Z-score: 1958.6 bits: 373.0 E(85289): 2.3e-102
Smith-Waterman score: 1833; 41.6% identity (75.5% similar) in 687 aa overlap (29-707:16-679)
10 20 30 40 50
pF1KE6 MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEE-LGRWGSAPRT--HQWR
:..:::.... :.: : ..: . . .
NP_996 MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLK
10 20 30 40
60 70 80 90 100 110
pF1KE6 TWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGL
. :. . .. . ::. ::: : ....::::.::.:....:::::::.:.::..
NP_996 QAFTCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAV
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE6 PPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALN-DSMINET--
::.::::::::::..: ..:::::::.: :::.:.:.:.:. :.:. . . .: :
NP_996 PPIFGLYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNG
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE6 --ARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLK
:::: ::.:: ....: :..: ::. .::::. ::.::::::.::::::.::.:.::
NP_996 TEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLK
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE6 YVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLP
:.::.. . .:: .:..:... : .. . .: .. .. .. .:. : .:......::
NP_996 YLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLP
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE6 MPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIA
::: :..... .:::: :..::. ..:::::..: ::.::. :.:.:: . .:..::
NP_996 APIPLEFFAVVMGTGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIA
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE6 VVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTG
.:::...::..: .: .:::.::.::::.:::: : ::..:: : .:::.:::::::.::
NP_996 IVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTG
350 360 370 380 390 400
420 430 440 450 460 470
pF1KE6 GNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRA
:..:.:: ..::.:::.:. : ::..::.:::.::.:::::::. :.::. .:....
NP_996 GKTQLAGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKI
410 420 430 440 450 460
480 490 500 510 520 530
pF1KE6 DLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYS
.: :::.::.....:.:: ::..:::..:: :. ::: : :.:::..:.::.: :. :
NP_996 ELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYE
470 480 490 500 510 520
540 550 560 570 580 590
pF1KE6 EAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQ
:.::. :.:.:. .: .:.::...::.:::.. ::. ... ..: ..:
NP_996 EVKEIPGIKIFQINAPIYYANSDLYSNALKRKTGVNPAVIMGARRKAMRKYA--------
530 540 550 560 570
600 610 620 630 640 650
pF1KE6 KEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMVSSGDKMEDATANGQEDSKAP
: .: ... :. ..... :: . . :: .. :. . . : :
NP_996 ---KEVGNANMANATVVKADAEVDGEDATKPEEEDGEV------KYPPIVIK----STFP
580 590 600 610 620
660 670 680 690 700 710
pF1KE6 DGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVV
. .. . : . :..:::. ..:.:.: .:.: .: ... .. . ::.:.:
NP_996 E--EMQRFMPPGDNVHTVILDFTQVNFIDSVGVKTLAGIVKEYGDVGIYVYLAGCSAFIQ
630 640 650 660 670 680
720 730 740 750
pF1KE6 SQLEAGHFFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
NP_996 R
>>XP_011514472 (OMIM: 604943,613865) PREDICTED: prestin (744 aa)
initn: 1908 init1: 1330 opt: 1769 Z-score: 1958.1 bits: 373.0 E(85289): 2.5e-102
Smith-Waterman score: 1902; 41.5% identity (75.1% similar) in 718 aa overlap (29-738:16-710)
10 20 30 40 50
pF1KE6 MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEE-LGRWGSAPRT--HQWR
:..:::.... :.: : ..: . . .
XP_011 MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLK
10 20 30 40
60 70 80 90 100 110
pF1KE6 TWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGL
. :. . .. . ::. ::: : ....::::.::.:....:::::::.:.::..
XP_011 QAFTCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAV
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE6 PPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALN-DSMINET--
::.::::::::::..: ..:::::::.: :::.:.:.:.:. :.:. . . .: :
XP_011 PPIFGLYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNG
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE6 --ARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLK
:::: ::.:: ....: :..: ::. .::::. ::.::::::.::::::.::.:.::
XP_011 TEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLK
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE6 YVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLP
:.::.. . .:: .:..:... : .. . .: .. .. .. .:. : .:......::
XP_011 YLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLP
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE6 MPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIA
::: :..... .:::: :..::. ..:::::..: ::.::. :.:.:: . .:..::
XP_011 APIPLEFFAVVMGTGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIA
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE6 VVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTG
.:::...::..: .: .:::.::.::::.:::: : ::..:: : .:::.:::::::.::
XP_011 IVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTG
350 360 370 380 390 400
420 430 440 450 460 470
pF1KE6 GNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRA
:..:.:: ..::.:::.:. : ::..::.:::.::.:::::::. :.::. .:....
XP_011 GKTQLAGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKI
410 420 430 440 450 460
480 490 500 510 520 530
pF1KE6 DLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYS
.: :::.::.....:.:: ::..:::..:: :. ::: : :.:::..:.::.: :. :
XP_011 ELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYE
470 480 490 500 510 520
540 550 560 570 580 590
pF1KE6 EAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQ
:.::. :.:.:. .: .:.::...::.:::.. ::. ... ..: ..:
XP_011 EVKEIPGIKIFQINAPIYYANSDLYSNALKRKTGVNPAVIMGARRKAMRKYA--------
530 540 550 560 570
600 610 620 630 640 650
pF1KE6 KEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMVSSGDKMEDATANGQEDSKAP
: .: ... :. ..... :: . . :: .. :. . . : :
XP_011 ---KEVGNANMANATVVKADAEVDGEDATKPEEEDGEV------KYPPIVIK----STFP
580 590 600 610 620
660 670 680 690 700 710
pF1KE6 DGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVV
. .. . : . :..:::. ..:.:.: .:.: .: ... .. . ::.:.: . ::
XP_011 E--EMQRFMPPGDNVHTVILDFTQVNFIDSVGVKTLAGIVKEYGDVGIYVYLAGCSAQVV
630 640 650 660 670 680
720 730 740 750
pF1KE6 SQLEAGHFFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
..: ..::. . :: :.::::
XP_011 NDLTRNRFFENPALWELLFHSIHDAVLGSQLREALAEQEASAPPSQEDLEPNATPATPEA
690 700 710 720 730 740
>>NP_945350 (OMIM: 604943,613865) prestin isoform a [Hom (744 aa)
initn: 1908 init1: 1330 opt: 1769 Z-score: 1958.1 bits: 373.0 E(85289): 2.5e-102
Smith-Waterman score: 1902; 41.5% identity (75.1% similar) in 718 aa overlap (29-738:16-710)
10 20 30 40 50
pF1KE6 MGLADASGPRDTQALLSATQAMDLRRRDYHMERPLLNQEHLEE-LGRWGSAPRT--HQWR
:..:::.... :.: : ..: . . .
NP_945 MDHAEENEILAATQRYYVERPIFSHPVLQERLHTKDKVPDSIADKLK
10 20 30 40
60 70 80 90 100 110
pF1KE6 TWLQCSRARAYALLLQHLPVLVWLPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGL
. :. . .. . ::. ::: : ....::::.::.:....:::::::.:.::..
NP_945 QAFTCTPKKIRNIIYMFLPITKWLPAYKFKEYVLGDLVSGISTGVLQLPQGLAFAMLAAV
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE6 PPVFGLYSSFYPVFIYFLFGTSRHISVGTFAVMSVMVGSVTESLAPQALN-DSMINET--
::.::::::::::..: ..:::::::.: :::.:.:.:.:. :.:. . . .: :
NP_945 PPIFGLYSSFYPVIMYCFLGTSRHISIGPFAVISLMIGGVAVRLVPDDIVIPGGVNATNG
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE6 --ARDAARVQVASTLSVLVGLFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLK
:::: ::.:: ....: :..: ::. .::::. ::.::::::.::::::.::.:.::
NP_945 TEARDALRVKVAMSVTLLSGIIQFCLGVCRFGFVAIYLTEPLVRGFTTAAAVHVFTSMLK
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE6 YVFGLHLSSHSGPLSLIYTVLEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLP
:.::.. . .:: .:..:... : .. . .: .. .. .. .:. : .:......::
NP_945 YLFGVKTKRYSGIFSVVYSTVAVLQNVKNLNVCSLGVGLMVFGLLLGGKEFNERFKEKLP
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE6 MPIPGELLTLIGATGISYGMGLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIA
::: :..... .:::: :..::. ..:::::..: ::.::. :.:.:: . .:..::
NP_945 APIPLEFFAVVMGTGISAGFNLKESYNVDVVGTLPLGLLPPANPDTSLFHLVYVDAIAIA
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE6 VVGFAIAISLGKIFALRHGYRVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTG
.:::...::..: .: .:::.::.::::.:::: : ::..:: : .:::.:::::::.::
NP_945 IVGFSVTISMAKTLANKHGYQVDGNQELIALGLCNSIGSLFQTFSISCSLSRSLVQEGTG
350 360 370 380 390 400
420 430 440 450 460 470
pF1KE6 GNSQVAGAISSLFILLIIVKLGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRA
:..:.:: ..::.:::.:. : ::..::.:::.::.:::::::. :.::. .:....
NP_945 GKTQLAGCLASLMILLVILATGFLFESLPQAVLSAIVIVNLKGMFMQFSDLPFFWRTSKI
410 420 430 440 450 460
480 490 500 510 520 530
pF1KE6 DLLIWLVTFTATILLNLDLGLVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYS
.: :::.::.....:.:: ::..:::..:: :. ::: : :.:::..:.::.: :. :
NP_945 ELTIWLTTFVSSLFLGLDYGLITAVIIALLTVIYRTQSPSYKVLGKLPETDVYIDIDAYE
470 480 490 500 510 520
540 550 560 570 580 590
pF1KE6 EAKEVRGVKVFRSSATVYFANAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQ
:.::. :.:.:. .: .:.::...::.:::.. ::. ... ..: ..:
NP_945 EVKEIPGIKIFQINAPIYYANSDLYSNALKRKTGVNPAVIMGARRKAMRKYA--------
530 540 550 560 570
600 610 620 630 640 650
pF1KE6 KEEKLRKQAASPKGASVSINVNTSLEDMRSNNVEDCKMMVSSGDKMEDATANGQEDSKAP
: .: ... :. ..... :: . . :: .. :. . . : :
NP_945 ---KEVGNANMANATVVKADAEVDGEDATKPEEEDGEV------KYPPIVIK----STFP
580 590 600 610 620
660 670 680 690 700 710
pF1KE6 DGSTLKALGLPQPDFHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVV
. .. . : . :..:::. ..:.:.: .:.: .: ... .. . ::.:.: . ::
NP_945 E--EMQRFMPPGDNVHTVILDFTQVNFIDSVGVKTLAGIVKEYGDVGIYVYLAGCSAQVV
630 640 650 660 670 680
720 730 740 750
pF1KE6 SQLEAGHFFDASITKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
..: ..::. . :: :.::::
NP_945 NDLTRNRFFENPALWELLFHSIHDAVLGSQLREALAEQEASAPPSQEDLEPNATPATPEA
690 700 710 720 730 740
>>NP_443166 (OMIM: 608481) solute carrier family 26 memb (791 aa)
initn: 1316 init1: 1178 opt: 1726 Z-score: 1910.2 bits: 364.2 E(85289): 1.2e-99
Smith-Waterman score: 1726; 37.3% identity (73.1% similar) in 713 aa overlap (51-748:32-744)
30 40 50 60 70 80
pF1KE6 AMDLRRRDYHMERPLLNQEHLEELGRWGSAPRTHQWRTWLQCSRARAYALLLQHLPVLVW
: .. :. ..:: :. :... :::: :
NP_443 SQPRPRYVVDRAAYSLTLFDDEFEKKDRTYPVGEKLRNAFRCSSAKIKAVVFGLLPVLSW
10 20 30 40 50 60
90 100 110 120 130 140
pF1KE6 LPRYPVRDWLLGDLLSGLSVAIMQLPQGLAYALLAGLPPVFGLYSSFYPVFIYFLFGTSR
::.: ..:... :::.::: . .:.:::.:.::::.:: : ::::::.:.. ::..: .
NP_443 LPKYKIKDYIIPDLLGGLSGGSIQVPQGMAFALLANLPAVNGLYSSFFPLLTYFFLGGVH
70 80 90 100 110 120
150 160 170 180 190
pF1KE6 HISVGTFAVMSVMVGSVTESLAPQ--------ALNDSMINETARDAARVQVASTLSVLVG
.. :::::.:..::.. .:::. : :.:... .: .: :..:..::. :..
NP_443 QMVPGTFAVISILVGNICLQLAPESKFQVFNNATNESYVDTAAMEAERLHVSATLACLTA
130 140 150 160 170 180
200 210 220 230 240 250
pF1KE6 LFQVGLGLIHFGFVVTYLSEPLVRGYTTAAAVQVFVSQLKYVFGLHLSSHSGPLSLIYTV
..:.:::...::::. :::: ..::. :::..:...: :::.::: . :..:: :...:
NP_443 IIQMGLGFMQFGFVAIYLSESFIRGFMTAAGLQILISVLKYIFGLTIPSYTGPGSIVFTF
190 200 210 220 230 240
260 270 280 290 300 310
pF1KE6 LEVCWKLPQSKVGTVVTAAVAGVVLVVVKLLNDKLQQQLPMPIPGELLTLIGATGISYGM
...: .::........ : ..:. ::.:: :: . .... .::: :..... ::.:: :
NP_443 IDICKNLPHTNIASLIFALISGAFLVLVKELNARYMHKIRFPIPTEMIVVVVATAISGGC
250 260 270 280 290 300
320 330 340 350 360 370
pF1KE6 GLKHRFEVDVVGNIPAGLVPPVAPNTQLFSKLVGSAFTIAVVGFAIAISLGKIFALRHGY
. .......::.: :. ::.: .. .. ..:.::..:.:...: ...:. .: .:::
NP_443 KMPKKYHMQIVGEIQRGFPTPVSPVVSQWKDMIGTAFSLAIVSYVINLAMGRTLANKHGY
310 320 330 340 350 360
380 390 400 410 420 430
pF1KE6 RVDSNQELVALGLSNLIGGIFQCFPVSCSMSRSLVQESTGGNSQVAGAISSLFILLIIVK
::::::..::: ::..:..:. . :..: .:. ...::.::::. :: ... ..
NP_443 DVDSNQEMIALGCSNFFGSFFKIHVICCALSVTLAVDGAGGKSQVASLCVSLVVMITMLV
370 380 390 400 410 420
440 450 460 470 480 490
pF1KE6 LGELFHDLPKAVLAAIIIVNLKGMLRQLSDMRSLWKANRADLLIWLVTFTATILLNLDLG
:: .. :::.::.:.: ::::. :.::.: ::. .. : ::.:.: ....:.: :
NP_443 LGIYLYPLPKSVLGALIAVNLKNSLKQLTDPYYLWRKSKLDCCIWVVSFLSSFFLSLPYG
430 440 450 460 470 480
500 510 520 530 540 550
pF1KE6 LVVAVIFSLLLVVVRTQMPHYSVLGQVPDTDIYRDVAEYSEAKEVRGVKVFRSSATVYFA
..:.: ::.:.:: .::. . .:.:: ::::: . :..:....:.:.. . .:::
NP_443 VAVGVAFSVLVVVFQTQFRNGYALAQVMDTDIYVNPKTYNRAQDIQGIKIITYCSPLYFA
490 500 510 520 530 540
560 570 580 590 600 610
pF1KE6 NAEFYSDALKQRCGVDVDFLISQKKKLLKKQEQLKLKQLQKEEKLRKQAASPKGASVSIN
:.:.. . . . :.: . .. :.: :::::. ... :....: .. . . .. .
NP_443 NSEIFRQKVIAKTGMDPQKVLLAKQKYLKKQEKRRMRPTQQRRSLFMKTKTVSLQELQQD
550 560 570 580 590 600
620 630 640 650 660
pF1KE6 V-NTSLEDMRSNNVEDCKMMVS----SGDKMEDATANGQEDSKAP-DGSTLKALGLPQPD
:. : .:.. :: : :. : .. ...:: . : . : :
NP_443 FENAPPTDPNNNQTPANGTSVSYITFSPDSSSPAQSEPPASAEAPGEPSDMLASVPPFVT
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE6 FHSLILDLGALSFVDTVCLKSLKNIFHDFREIEVEVYMAACHSPVVSQLEAGHFF-DASI
::.::::....:::: . .:.: .. . .: :.:... :. : ... : : :.:.
NP_443 FHTLILDMSGVSFVDLMGIKALAKLSSTYGKIGVKVFLVNIHAQVYNDISHGGVFEDGSL
670 680 690 700 710 720
730 740 750
pF1KE6 TKKHLFASVHDAVTFALQHPRPVPDSPVSVTRL
::.: :.:::: :: . : :
NP_443 ECKHVFPSIHDAVLFAQANARDVTPGHNFQGAPGDAELSLYDSEEDIRSYWDLEQEMFGS
730 740 750 760 770 780
758 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 15:30:26 2016 done: Tue Nov 8 15:30:27 2016
Total Scan time: 9.530 Total Display time: 0.190
Function used was FASTA [36.3.4 Apr, 2011]