Result of FASTA (omim) for
pFN21AE6695
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6695, 335 aa
1>>>pF1KE6695 335 - 335 aa - 335 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9547+/-0.000376; mu= 18.1972+/- 0.023
mean_var=68.9603+/-13.737, 0's: 0 Z-trim(112.9): 58 B-trim: 62 in 1/52
Lambda= 0.154445
statistics sampled from 21919 (21977) to 21919 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.632), E-opt: 0.2 (0.258), width: 16
Scan time: 4.490
The best scores are: opt bits E(85289)
NP_004381 (OMIM: 116820) pro-cathepsin H isoform a ( 335) 2349 532.5 4.8e-151
XP_016877441 (OMIM: 116820) PREDICTED: pro-catheps ( 297) 2081 472.7 4.2e-133
XP_005254238 (OMIM: 116820) PREDICTED: pro-catheps ( 297) 2081 472.7 4.2e-133
XP_016877440 (OMIM: 116820) PREDICTED: pro-catheps ( 317) 2068 469.9 3.3e-132
NP_001306066 (OMIM: 116820) pro-cathepsin H isofor ( 201) 1207 277.9 1.3e-74
XP_011519578 (OMIM: 116820) PREDICTED: pro-catheps ( 169) 1143 263.5 2.2e-70
NP_000387 (OMIM: 265800,601105) cathepsin K prepro ( 329) 804 188.2 2e-47
NP_001903 (OMIM: 116880) cathepsin L1 isoform 1 pr ( 333) 799 187.1 4.5e-47
NP_666023 (OMIM: 116880) cathepsin L1 isoform 1 pr ( 333) 799 187.1 4.5e-47
NP_001244901 (OMIM: 116880) cathepsin L1 isoform 1 ( 333) 799 187.1 4.5e-47
XP_005251773 (OMIM: 116880) PREDICTED: cathepsin L ( 333) 799 187.1 4.5e-47
NP_001244900 (OMIM: 116880) cathepsin L1 isoform 1 ( 333) 799 187.1 4.5e-47
NP_001188504 (OMIM: 603308) cathepsin L2 prepropro ( 334) 792 185.6 1.3e-46
NP_001324 (OMIM: 603308) cathepsin L2 preproprotei ( 334) 792 185.6 1.3e-46
NP_004070 (OMIM: 116845) cathepsin S isoform 1 pre ( 331) 725 170.6 4.1e-42
XP_011543630 (OMIM: 603539,615362) PREDICTED: cath ( 424) 669 158.2 2.8e-38
NP_003784 (OMIM: 603539,615362) cathepsin F precur ( 484) 669 158.3 3.1e-38
NP_001186668 (OMIM: 116845) cathepsin S isoform 2 ( 281) 584 139.2 1e-32
XP_016869782 (OMIM: 116880) PREDICTED: cathepsin L ( 272) 575 137.1 4e-32
XP_011516565 (OMIM: 116880) PREDICTED: cathepsin L ( 272) 575 137.1 4e-32
NP_001325 (OMIM: 600550) cathepsin O preproprotein ( 321) 535 128.3 2.2e-29
NP_001805 (OMIM: 170650,245000,245010,602365) dipe ( 463) 383 94.5 4.6e-19
NP_001244902 (OMIM: 116880) cathepsin L1 isoform 2 ( 151) 375 92.4 6.7e-19
NP_001304166 (OMIM: 116810) cathepsin B isoform 2 ( 215) 277 70.7 3.3e-12
XP_016868590 (OMIM: 116810) PREDICTED: cathepsin B ( 245) 277 70.7 3.6e-12
NP_680093 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 277 70.8 4.7e-12
NP_680092 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 277 70.8 4.7e-12
NP_680090 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 277 70.8 4.7e-12
XP_016868586 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 277 70.8 4.7e-12
XP_006716307 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 277 70.8 4.7e-12
NP_001899 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 277 70.8 4.7e-12
XP_011542114 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 277 70.8 4.7e-12
XP_006716308 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 277 70.8 4.7e-12
XP_016868589 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 277 70.8 4.7e-12
XP_016868588 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 277 70.8 4.7e-12
XP_016868587 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 277 70.8 4.7e-12
NP_680091 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 277 70.8 4.7e-12
NP_001327 (OMIM: 603169) cathepsin Z preproprotein ( 303) 185 50.3 6.3e-06
NP_001326 (OMIM: 602364) cathepsin W preproprotein ( 376) 174 47.9 4.1e-05
XP_005271163 (OMIM: 616064) PREDICTED: tubulointer ( 440) 167 46.4 0.00014
NP_001191344 (OMIM: 616064) tubulointerstitial nep ( 362) 151 42.8 0.0014
XP_005271164 (OMIM: 616064) PREDICTED: tubulointer ( 362) 151 42.8 0.0014
XP_011540248 (OMIM: 616064) PREDICTED: tubulointer ( 408) 151 42.8 0.0015
NP_001191343 (OMIM: 616064) tubulointerstitial nep ( 436) 151 42.8 0.0016
NP_071447 (OMIM: 616064) tubulointerstitial nephri ( 467) 151 42.8 0.0017
XP_016866237 (OMIM: 606749) PREDICTED: tubulointer ( 309) 143 40.9 0.0042
XP_016866236 (OMIM: 606749) PREDICTED: tubulointer ( 351) 143 41.0 0.0047
XP_016866235 (OMIM: 606749) PREDICTED: tubulointer ( 401) 143 41.0 0.0052
XP_011512799 (OMIM: 606749) PREDICTED: tubulointer ( 426) 143 41.0 0.0054
XP_006715125 (OMIM: 606749) PREDICTED: tubulointer ( 458) 143 41.1 0.0057
>>NP_004381 (OMIM: 116820) pro-cathepsin H isoform a pre (335 aa)
initn: 2349 init1: 2349 opt: 2349 Z-score: 2832.6 bits: 532.5 E(85289): 4.8e-151
Smith-Waterman score: 2349; 99.7% identity (99.7% similar) in 335 aa overlap (1-335:1-335)
10 20 30 40 50 60
pF1KE6 MWATLPLLCAGAWLLGVPVCGAAELSVNSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFAS
::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::
NP_004 MWATLPLLCAGAWLLGVPVCGAAELCVNSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFAS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 NWRKINAHNNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NWRKINAHNNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 DWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 CQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 CQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 EAVALYNPVSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 EAVALYNPVSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVK
250 260 270 280 290 300
310 320 330
pF1KE6 NSWGPQWGMNGYFLIERGKNMCGLAACASYPIPLV
:::::::::::::::::::::::::::::::::::
NP_004 NSWGPQWGMNGYFLIERGKNMCGLAACASYPIPLV
310 320 330
>>XP_016877441 (OMIM: 116820) PREDICTED: pro-cathepsin H (297 aa)
initn: 2081 init1: 2081 opt: 2081 Z-score: 2510.6 bits: 472.7 E(85289): 4.2e-133
Smith-Waterman score: 2081; 100.0% identity (100.0% similar) in 297 aa overlap (39-335:1-297)
10 20 30 40 50 60
pF1KE6 CAGAWLLGVPVCGAAELSVNSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFASNWRKINAH
::::::::::::::::::::::::::::::
XP_016 MSKHRKTYSTEEYHHRLQTFASNWRKINAH
10 20 30
70 80 90 100 110 120
pF1KE6 NNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSVDWRKKGNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSVDWRKKGNF
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE6 VSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHGCQGGLPSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHGCQGGLPSQ
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE6 AFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMVEAVALYNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMVEAVALYNP
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE6 VSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVKNSWGPQWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVKNSWGPQWG
220 230 240 250 260 270
310 320 330
pF1KE6 MNGYFLIERGKNMCGLAACASYPIPLV
:::::::::::::::::::::::::::
XP_016 MNGYFLIERGKNMCGLAACASYPIPLV
280 290
>>XP_005254238 (OMIM: 116820) PREDICTED: pro-cathepsin H (297 aa)
initn: 2081 init1: 2081 opt: 2081 Z-score: 2510.6 bits: 472.7 E(85289): 4.2e-133
Smith-Waterman score: 2081; 100.0% identity (100.0% similar) in 297 aa overlap (39-335:1-297)
10 20 30 40 50 60
pF1KE6 CAGAWLLGVPVCGAAELSVNSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFASNWRKINAH
::::::::::::::::::::::::::::::
XP_005 MSKHRKTYSTEEYHHRLQTFASNWRKINAH
10 20 30
70 80 90 100 110 120
pF1KE6 NNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSVDWRKKGNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSVDWRKKGNF
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE6 VSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHGCQGGLPSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHGCQGGLPSQ
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE6 AFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMVEAVALYNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMVEAVALYNP
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE6 VSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVKNSWGPQWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVKNSWGPQWG
220 230 240 250 260 270
310 320 330
pF1KE6 MNGYFLIERGKNMCGLAACASYPIPLV
:::::::::::::::::::::::::::
XP_005 MNGYFLIERGKNMCGLAACASYPIPLV
280 290
>>XP_016877440 (OMIM: 116820) PREDICTED: pro-cathepsin H (317 aa)
initn: 2068 init1: 2068 opt: 2068 Z-score: 2494.6 bits: 469.9 E(85289): 3.3e-132
Smith-Waterman score: 2068; 99.3% identity (99.7% similar) in 297 aa overlap (39-335:21-317)
10 20 30 40 50 60
pF1KE6 CAGAWLLGVPVCGAAELSVNSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFASNWRKINAH
: .:::::::::::::::::::::::::::
XP_016 MVIFAVNLTQHQQWRPGVPHMWQHRKTYSTEEYHHRLQTFASNWRKINAH
10 20 30 40 50
70 80 90 100 110 120
pF1KE6 NNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSVDWRKKGNF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSVDWRKKGNF
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE6 VSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHGCQGGLPSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHGCQGGLPSQ
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE6 AFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMVEAVALYNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMVEAVALYNP
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE6 VSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVKNSWGPQWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSFAFEVTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVKNSWGPQWG
240 250 260 270 280 290
310 320 330
pF1KE6 MNGYFLIERGKNMCGLAACASYPIPLV
:::::::::::::::::::::::::::
XP_016 MNGYFLIERGKNMCGLAACASYPIPLV
300 310
>>NP_001306066 (OMIM: 116820) pro-cathepsin H isoform c (201 aa)
initn: 1207 init1: 1207 opt: 1207 Z-score: 1460.5 bits: 277.9 E(85289): 1.3e-74
Smith-Waterman score: 1207; 100.0% identity (100.0% similar) in 171 aa overlap (165-335:31-201)
140 150 160 170 180 190
pF1KE6 QGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHGCQGGLPSQAFEYIL
::::::::::::::::::::::::::::::
NP_001 MWLSQGGLAPHAKALTASQLAGHWVVSFFQAEQQLVDCAQDFNNHGCQGGLPSQAFEYIL
10 20 30 40 50 60
200 210 220 230 240 250
pF1KE6 YNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMVEAVALYNPVSFAFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMVEAVALYNPVSFAFE
70 80 90 100 110 120
260 270 280 290 300 310
pF1KE6 VTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVKNSWGPQWGMNGYFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTQDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGYGEKNGIPYWIVKNSWGPQWGMNGYFL
130 140 150 160 170 180
320 330
pF1KE6 IERGKNMCGLAACASYPIPLV
:::::::::::::::::::::
NP_001 IERGKNMCGLAACASYPIPLV
190 200
>>XP_011519578 (OMIM: 116820) PREDICTED: pro-cathepsin H (169 aa)
initn: 1159 init1: 1143 opt: 1143 Z-score: 1384.5 bits: 263.5 E(85289): 2.2e-70
Smith-Waterman score: 1143; 98.2% identity (98.8% similar) in 166 aa overlap (1-166:1-166)
10 20 30 40 50 60
pF1KE6 MWATLPLLCAGAWLLGVPVCGAAELSVNSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFAS
::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::
XP_011 MWATLPLLCAGAWLLGVPVCGAAELCVNSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFAS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 NWRKINAHNNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NWRKINAHNNGNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPYPPSV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 DWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQDFNNHG
:::::::::::::::::::::::::::::::::::::::::::: .
XP_011 DWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLPQLSS
130 140 150 160
190 200 210 220 230 240
pF1KE6 CQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITIYDEEAMV
>>NP_000387 (OMIM: 265800,601105) cathepsin K preproprot (329 aa)
initn: 422 init1: 225 opt: 804 Z-score: 972.3 bits: 188.2 E(85289): 2e-47
Smith-Waterman score: 804; 41.9% identity (68.6% similar) in 334 aa overlap (11-331:3-327)
10 20 30 40 50
pF1KE6 MWATLPLLCAGAWLLGVPVCGAAELSVNSLEKFHFKSWMSKHRKTYST--EEYHHRLQTF
: .: .:: . : : . . :.. : . ::: :.. .: .:: .
NP_000 MWGLKVLLLPVVSFA-LYPEEILDTHWELWKKTHRKQYNNKVDEISRRL-IW
10 20 30 40 50
60 70 80 90 100 110
pF1KE6 ASNWRKINAHNN----GNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSN---YL-
.: . :. :: : ::...:.:...::. :. .: . . : ..:: :.
NP_000 EKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQK-MTGLKVPLSHSRSNDTLYIP
60 70 80 90 100
120 130 140 150 160 170
pF1KE6 RGTGPYPPSVDWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLV
. : : :::.:::: .:.:::::: :::::.::..::::. . :::.:.:. :.::
NP_000 EWEGRAPDSVDYRKKG-YVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLV
110 120 130 140 150 160
180 190 200 210 220
pF1KE6 DCAQDFNNHGCQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYCKFQP-GKAIGFVKDVA
::... : :: :: ..::.:. :.:: .::.::: :.. : ..: ::: .
NP_000 DCVSE--NDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAK-CRGYR
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE6 NITIYDEEAMVEAVALYNPVSFAFEVT-QDFMMYRTGIYSSTSCHKTPDKVNHAVLAVGY
.: .:.:. .::: .::: :.... .:..: :.: . ::.. :..:::::::::
NP_000 EIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNS--DNLNHAVLAVGY
230 240 250 260 270 280
290 300 310 320 330
pF1KE6 GEKNGIPYWIVKNSWGPQWGMNGYFLIERGKN-MCGLAACASYPIPLV
: ..: .::.::::: .:: .::.:. :.:: ::.: ::.:
NP_000 GIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
290 300 310 320
>>NP_001903 (OMIM: 116880) cathepsin L1 isoform 1 prepro (333 aa)
initn: 576 init1: 379 opt: 799 Z-score: 966.2 bits: 187.1 E(85289): 4.5e-47
Smith-Waterman score: 799; 38.3% identity (69.0% similar) in 339 aa overlap (6-331:3-331)
10 20 30 40 50 60
pF1KE6 MWATLPLLCAGAWLLGVPVCGAAELSVNSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFAS
: : .:. ::. ..: :. . . .. .: . : . :. .: : .. .
NP_001 MNPTLILAAFCLGI---ASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEK
10 20 30 40 50
70 80 90 100 110
pF1KE6 NWRKINAHNN----GNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPY
: . :. ::. :.:.: ::.: :.::. :... . . :: . :.. .. :
NP_001 NMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQ--VMNGFQNRKPRKGKVFQEPLFY
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE6 --PPSVDWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQ
: :::::.:: .:.:::::: :::::.::.:::::. . ::...::.::.::::.
NP_001 EAPRSVDWREKG-YVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE6 DFNNHGCQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITI-
.:.::.::: . ::.:. : :. .:..:::.. . ::..: ... .:.. . :
NP_001 PQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVA--NDTGFVDIP
180 190 200 210 220
240 250 260 270 280
pF1KE6 YDEEAMVEAVALYNPVSFAFEVTQD-FMMYRTGIYSSTSCHKTPDKVNHAVLAVGYG---
.:.:...::: .:.: :... .. :..:. ::: .: . . ..:.::.::::
NP_001 KQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDC--SSEDMDHGVLVVGYGFES
230 240 250 260 270 280
290 300 310 320 330
pF1KE6 -EKNGIPYWIVKNSWGPQWGMNGYFLIERGK-NMCGLAACASYPIPLV
:... ::.:::::: .:::.:: . . . : ::.:. ::::
NP_001 TESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
290 300 310 320 330
>>NP_666023 (OMIM: 116880) cathepsin L1 isoform 1 prepro (333 aa)
initn: 576 init1: 379 opt: 799 Z-score: 966.2 bits: 187.1 E(85289): 4.5e-47
Smith-Waterman score: 799; 38.3% identity (69.0% similar) in 339 aa overlap (6-331:3-331)
10 20 30 40 50 60
pF1KE6 MWATLPLLCAGAWLLGVPVCGAAELSVNSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFAS
: : .:. ::. ..: :. . . .. .: . : . :. .: : .. .
NP_666 MNPTLILAAFCLGI---ASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEK
10 20 30 40 50
70 80 90 100 110
pF1KE6 NWRKINAHNN----GNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPY
: . :. ::. :.:.: ::.: :.::. :... . . :: . :.. .. :
NP_666 NMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQ--VMNGFQNRKPRKGKVFQEPLFY
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE6 --PPSVDWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQ
: :::::.:: .:.:::::: :::::.::.:::::. . ::...::.::.::::.
NP_666 EAPRSVDWREKG-YVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE6 DFNNHGCQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITI-
.:.::.::: . ::.:. : :. .:..:::.. . ::..: ... .:.. . :
NP_666 PQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVA--NDTGFVDIP
180 190 200 210 220
240 250 260 270 280
pF1KE6 YDEEAMVEAVALYNPVSFAFEVTQD-FMMYRTGIYSSTSCHKTPDKVNHAVLAVGYG---
.:.:...::: .:.: :... .. :..:. ::: .: . . ..:.::.::::
NP_666 KQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDC--SSEDMDHGVLVVGYGFES
230 240 250 260 270 280
290 300 310 320 330
pF1KE6 -EKNGIPYWIVKNSWGPQWGMNGYFLIERGK-NMCGLAACASYPIPLV
:... ::.:::::: .:::.:: . . . : ::.:. ::::
NP_666 TESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
290 300 310 320 330
>>NP_001244901 (OMIM: 116880) cathepsin L1 isoform 1 pre (333 aa)
initn: 576 init1: 379 opt: 799 Z-score: 966.2 bits: 187.1 E(85289): 4.5e-47
Smith-Waterman score: 799; 38.3% identity (69.0% similar) in 339 aa overlap (6-331:3-331)
10 20 30 40 50 60
pF1KE6 MWATLPLLCAGAWLLGVPVCGAAELSVNSLEKFHFKSWMSKHRKTYSTEEYHHRLQTFAS
: : .:. ::. ..: :. . . .. .: . : . :. .: : .. .
NP_001 MNPTLILAAFCLGI---ASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEK
10 20 30 40 50
70 80 90 100 110
pF1KE6 NWRKINAHNN----GNHTFKMALNQFSDMSFAEIKHKYLWSEPQNCSATKSNYLRGTGPY
: . :. ::. :.:.: ::.: :.::. :... . . :: . :.. .. :
NP_001 NMKMIELHNQEYREGKHSFTMAMNAFGDMTSEEFRQ--VMNGFQNRKPRKGKVFQEPLFY
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE6 --PPSVDWRKKGNFVSPVKNQGACGSCWTFSTTGALESAIAIATGKMLSLAEQQLVDCAQ
: :::::.:: .:.:::::: :::::.::.:::::. . ::...::.::.::::.
NP_001 EAPRSVDWREKG-YVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE6 DFNNHGCQGGLPSQAFEYILYNKGIMGEDTYPYQGKDGYCKFQPGKAIGFVKDVANITI-
.:.::.::: . ::.:. : :. .:..:::.. . ::..: ... .:.. . :
NP_001 PQGNEGCNGGLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVA--NDTGFVDIP
180 190 200 210 220
240 250 260 270 280
pF1KE6 YDEEAMVEAVALYNPVSFAFEVTQD-FMMYRTGIYSSTSCHKTPDKVNHAVLAVGYG---
.:.:...::: .:.: :... .. :..:. ::: .: . . ..:.::.::::
NP_001 KQEKALMKAVATVGPISVAIDAGHESFLFYKEGIYFEPDC--SSEDMDHGVLVVGYGFES
230 240 250 260 270 280
290 300 310 320 330
pF1KE6 -EKNGIPYWIVKNSWGPQWGMNGYFLIERGK-NMCGLAACASYPIPLV
:... ::.:::::: .:::.:: . . . : ::.:. ::::
NP_001 TESDNNKYWLVKNSWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
290 300 310 320 330
335 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 15:29:11 2016 done: Tue Nov 8 15:29:12 2016
Total Scan time: 4.490 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]