FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE6689, 278 aa
  1>>>pF1KE6689 278 - 278 aa - 278 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 4.8976+/-0.000352; mu= 17.1199+/- 0.022
 mean_var=63.5148+/-12.339, 0's: 0 Z-trim(114.0): 13  B-trim: 44 in 1/53
 Lambda= 0.160930
 statistics sampled from 23655 (23665) to 23655 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.654), E-opt: 0.2 (0.277), width:  16
 Scan time:  5.470

The best scores are:                                      opt bits E(85289)
NP_683762 (OMIM: 609713) checkpoint protein HUS1B  ( 278) 1811 429.0 4.7e-120
NP_004498 (OMIM: 603760) checkpoint protein HUS1 [ ( 280)  927 223.8 2.9e-58
XP_016867604 (OMIM: 603760) PREDICTED: checkpoint  ( 259)  856 207.3 2.5e-53


>>NP_683762 (OMIM: 609713) checkpoint protein HUS1B [Hom  (278 aa)
 initn: 1811 init1: 1811 opt: 1811  Z-score: 2276.3  bits: 429.0 E(85289): 4.7e-120
Smith-Waterman score: 1811; 99.6% identity (99.6% similar) in 278 aa overlap (1-278:1-278)

               10        20        30        40        50        60
pF1KE6 MKFRAKITGKGCLELFIHVSGTVARLAKVCVLRVRPDSLCFGPAGSGGLHEARLWCEVRQ
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 MKFRAKITGKGCLELFIHVSGTVARLAKVCVLRVRPDSLCFGPAGSGGLHEARLWCEVRQ
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE6 GAFQQFRMEGVSEDLDEIHLELTAEHLSRAARSAAGASSLKLQLTHKRRPSLTVAVELVS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 GAFQQFRMEGVSEDLDEIHLELTAEHLSRAARSAAGASSLKLQLTHKRRPSLTVAVELVS
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE6 SLGRARSVVHDLPVRVLPRRVWRDCLPPSLRASDASIRLPRWRTLRSIVERMANVGSHVL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 SLGRARSVVHDLPVRVLPRRVWRDCLPPSLRASDASIRLPRWRTLRSIVERMANVGSHVL
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE6 VEANLSGRMTLSIETEVVSIQSYFKNLGNPPQSAVGVPENRDLESMVQVRVDNRKLLQFL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_683 VEANLSGRMTLSIETEVVSIQSYFKNLGNPPQSAVGVPENRDLESMVQVRVDNRKLLQFL
              190       200       210       220       230       240

              250       260       270        
pF1KE6 EGQQIHPTTALCNIWDNTLLQLVLVQEYVSLQYFIPAL
       ::::::::::::::::::::::::::: ::::::::::
NP_683 EGQQIHPTTALCNIWDNTLLQLVLVQEDVSLQYFIPAL
              250       260       270        

>>NP_004498 (OMIM: 603760) checkpoint protein HUS1 [Homo  (280 aa)
 initn: 760 init1: 760 opt: 927  Z-score: 1167.1  bits: 223.8 E(85289): 2.9e-58
Smith-Waterman score: 927; 48.9% identity (80.9% similar) in 282 aa overlap (1-278:1-279)

               10        20        30        40           50       
pF1KE6 MKFRAKITGKGCLELFIHVSGTVARLAKVCVLRVRPDSLCF---GPAGSGGLHEARLWCE
       :::::::.  .::. : ..:. .:.:::.:.::. ::.: :      ..::.    .:::
NP_004 MKFRAKIVDGACLNHFTRISNMIAKLAKTCTLRISPDKLNFILCDKLANGGVS---MWCE
               10        20        30        40        50          

        60         70        80        90       100       110      
pF1KE6 VRQ-GAFQQFRMEGVSEDLDEIHLELTAEHLSRAARSAAGASSLKLQLTHKRRPSLTVAV
       ..: . :..:.::::: . .::.::::.:.:::: ..: .: .::..::.:. : :::.:
NP_004 LEQENFFNEFQMEGVSAENNEIYLELTSENLSRALKTAQNARALKIKLTNKHFPCLTVSV
        60        70        80        90       100       110       

        120       130       140       150       160       170      
pF1KE6 ELVSSLGRARSVVHDLPVRVLPRRVWRDCLPPSLRASDASIRLPRWRTLRSIVERMANVG
       ::.:  . .: :.::.:..:.::..:.:   : .   :.:: ::  .:..:.::.: :..
NP_004 ELLSMSSSSRIVTHDIPIKVIPRKLWKDLQEPVVPDPDVSIYLPVLKTMKSVVEKMKNIS
       120       130       140       150       160       170       

        180       190       200       210       220       230      
pF1KE6 SHVLVEANLSGRMTLSIETEVVSIQSYFKNLGNPPQSAVGVPENRDLESMVQVRVDNRKL
       .:...::::.:...:.::::.: . ..::.::::: .. .. :.:..: :..:..: :::
NP_004 NHLVIEANLDGELNLKIETELVCVTTHFKDLGNPPLASESTHEDRNVEHMAEVHIDIRKL
       180       190       200       210       220       230       

        240       250       260       270         
pF1KE6 LQFLEGQQIHPTTALCNIWDNTLLQLVLVQEYVSLQYFIPAL 
       :::: :::..:: ::::: .: .... :..: :::::::::: 
NP_004 LQFLAGQQVNPTKALCNIVNNKMVHFDLLHEDVSLQYFIPALS
       240       250       260       270       280

>>XP_016867604 (OMIM: 603760) PREDICTED: checkpoint prot  (259 aa)
 initn: 844 init1: 760 opt: 856  Z-score: 1078.4  bits: 207.3 E(85289): 2.5e-53
Smith-Waterman score: 856; 48.8% identity (81.2% similar) in 260 aa overlap (23-278:2-258)

               10        20        30        40           50       
pF1KE6 MKFRAKITGKGCLELFIHVSGTVARLAKVCVLRVRPDSLCF---GPAGSGGLHEARLWCE
                             .:.:::.:.::. ::.: :      ..::.    .:::
XP_016                      MIAKLAKTCTLRISPDKLNFILCDKLANGGVS---MWCE
                                    10        20        30         

        60         70        80        90       100       110      
pF1KE6 VRQ-GAFQQFRMEGVSEDLDEIHLELTAEHLSRAARSAAGASSLKLQLTHKRRPSLTVAV
       ..: . :..:.::::: . .::.::::.:.:::: ..: .: .::..::.:. : :::.:
XP_016 LEQENFFNEFQMEGVSAENNEIYLELTSENLSRALKTAQNARALKIKLTNKHFPCLTVSV
         40        50        60        70        80        90      

        120       130       140       150       160       170      
pF1KE6 ELVSSLGRARSVVHDLPVRVLPRRVWRDCLPPSLRASDASIRLPRWRTLRSIVERMANVG
       ::.:  . .: :.::.:..:.::..:.:   : .   :.:: ::  .:..:.::.: :..
XP_016 ELLSMSSSSRIVTHDIPIKVIPRKLWKDLQEPVVPDPDVSIYLPVLKTMKSVVEKMKNIS
        100       110       120       130       140       150      

        180       190       200       210       220       230      
pF1KE6 SHVLVEANLSGRMTLSIETEVVSIQSYFKNLGNPPQSAVGVPENRDLESMVQVRVDNRKL
       .:...::::.:...:.::::.: . ..::.::::: .. .. :.:..: :..:..: :::
XP_016 NHLVIEANLDGELNLKIETELVCVTTHFKDLGNPPLASESTHEDRNVEHMAEVHIDIRKL
        160       170       180       190       200       210      

        240       250       260       270         
pF1KE6 LQFLEGQQIHPTTALCNIWDNTLLQLVLVQEYVSLQYFIPAL 
       :::: :::..:: ::::: .: .... :..: :::::::::: 
XP_016 LQFLAGQQVNPTKALCNIVNNKMVHFDLLHEDVSLQYFIPALS
        220       230       240       250         




278 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Tue Nov  8 15:25:51 2016 done: Tue Nov  8 15:25:52 2016
 Total Scan time:  5.470 Total Display time: -0.030

Function used was FASTA [36.3.4 Apr, 2011]