Result of FASTA (omim) for
pFN21AE6655
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6655, 253 aa
1>>>pF1KE6655 253 - 253 aa - 253 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.0936+/-0.000304; mu= 16.5899+/- 0.019
mean_var=68.2856+/-13.652, 0's: 0 Z-trim(116.8): 27 B-trim: 0 in 0/56
Lambda= 0.155206
statistics sampled from 28308 (28332) to 28308 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.704), E-opt: 0.2 (0.332), width: 16
Scan time: 5.970
The best scores are: opt bits E(85289)
NP_000281 (OMIM: 261670,612931) phosphoglycerate m ( 253) 1714 392.2 4.9e-109
NP_002620 (OMIM: 172250) phosphoglycerate mutase 1 ( 254) 1443 331.5 9e-91
NP_001025062 (OMIM: 300567) phosphoglycerate mutas ( 254) 1371 315.4 6.4e-86
NP_001304008 (OMIM: 172250) phosphoglycerate mutas ( 239) 1220 281.5 9.2e-76
NP_001280014 (OMIM: 222800,613896) bisphosphoglyce ( 259) 978 227.4 2e-59
NP_954655 (OMIM: 222800,613896) bisphosphoglycerat ( 259) 978 227.4 2e-59
XP_011514829 (OMIM: 222800,613896) PREDICTED: bisp ( 259) 978 227.4 2e-59
NP_001715 (OMIM: 222800,613896) bisphosphoglycerat ( 259) 978 227.4 2e-59
NP_065108 (OMIM: 610775) fructose-2,6-bisphosphata ( 270) 140 39.7 0.0064
>>NP_000281 (OMIM: 261670,612931) phosphoglycerate mutas (253 aa)
initn: 1714 init1: 1714 opt: 1714 Z-score: 2078.6 bits: 392.2 E(85289): 4.9e-109
Smith-Waterman score: 1714; 100.0% identity (100.0% similar) in 253 aa overlap (1-253:1-253)
10 20 30 40 50 60
pF1KE6 MATHRLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MATHRLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 KRAIRTLWAILDGTDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEEQVKIWRRSFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KRAIRTLWAILDGTDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEEQVKIWRRSFD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 IPPPPMDEKHPYYNSISKERRYAGLKPGELPTCESLKDTIARALPFWNEEIVPQIKAGKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IPPPPMDEKHPYYNSISKERRYAGLKPGELPTCESLKDTIARALPFWNEEIVPQIKAGKR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 VLIAAHGNSLRGIVKHLEGMSDQAIMELNLPTGIPIVYELNKELKPTKPMQFLGDEETVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 VLIAAHGNSLRGIVKHLEGMSDQAIMELNLPTGIPIVYELNKELKPTKPMQFLGDEETVR
190 200 210 220 230 240
250
pF1KE6 KAMEAVAAQGKAK
:::::::::::::
NP_000 KAMEAVAAQGKAK
250
>>NP_002620 (OMIM: 172250) phosphoglycerate mutase 1 iso (254 aa)
initn: 1443 init1: 1443 opt: 1443 Z-score: 1750.6 bits: 331.5 E(85289): 9e-91
Smith-Waterman score: 1443; 81.0% identity (93.3% similar) in 253 aa overlap (1-253:1-253)
10 20 30 40 50 60
pF1KE6 MATHRLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVL
::...::..:::::.:: :::: ::.::.:: : ::::::..:..:: .:::::.:::
NP_002 MAAYKLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 KRAIRTLWAILDGTDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEEQVKIWRRSFD
::::::::..::. ::::::::::::::::::::::::::::::::::: ::::::::.:
NP_002 KRAIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEAQVKIWRRSYD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 IPPPPMDEKHPYYNSISKERRYAGLKPGELPTCESLKDTIARALPFWNEEIVPQIKAGKR
.:::::. ::.:..:::.:::: : .::.:::::::::::::::::::::::: :::
NP_002 VPPPPMEPDHPFYSNISKDRRYADLTEDQLPSCESLKDTIARALPFWNEEIVPQIKEGKR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 VLIAAHGNSLRGIVKHLEGMSDQAIMELNLPTGIPIVYELNKELKPTKPMQFLGDEETVR
:::::::::::::::::::.:..:::::::::::::::::.:.::: :::::::::::::
NP_002 VLIAAHGNSLRGIVKHLEGLSEEAIMELNLPTGIPIVYELDKNLKPIKPMQFLGDEETVR
190 200 210 220 230 240
250
pF1KE6 KAMEAVAAQGKAK
:::::::::::::
NP_002 KAMEAVAAQGKAKK
250
>>NP_001025062 (OMIM: 300567) phosphoglycerate mutase 4 (254 aa)
initn: 1371 init1: 1371 opt: 1371 Z-score: 1663.5 bits: 315.4 E(85289): 6.4e-86
Smith-Waterman score: 1371; 77.9% identity (91.3% similar) in 253 aa overlap (1-253:1-253)
10 20 30 40 50 60
pF1KE6 MATHRLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVL
::...::..:::::::: :::: :.::.:: : ::::::..:..:: .::::: :::
NP_001 MAAYKLVLIRHGESTWNLENRFSCWYDADLSPAGHEEAKRGGQALRDAGYEFDICLTSVQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 KRAIRTLWAILDGTDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEEQVKIWRRSFD
::.:::::..::. ::::::::::::::::::::::::::::::::::: ::::::::.:
NP_001 KRVIRTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEAQVKIWRRSYD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 IPPPPMDEKHPYYNSISKERRYAGLKPGELPTCESLKDTIARALPFWNEEIVPQIKAGKR
.:::::. ::.:..:::.:::: : .::. :: :::::::::::::::::::: :::
NP_001 VPPPPMEPDHPFYSNISKDRRYADLTEDQLPSYESPKDTIARALPFWNEEIVPQIKEGKR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 VLIAAHGNSLRGIVKHLEGMSDQAIMELNLPTGIPIVYELNKELKPTKPMQFLGDEETVR
::::::::::.::.::.::.:..:::::::::::::::::.:.::: ::::::::::::
NP_001 VLIAAHGNSLQGIAKHVEGLSEEAIMELNLPTGIPIVYELDKNLKPIKPMQFLGDEETVC
190 200 210 220 230 240
250
pF1KE6 KAMEAVAAQGKAK
::.::::::::::
NP_001 KAIEAVAAQGKAKK
250
>>NP_001304008 (OMIM: 172250) phosphoglycerate mutase 1 (239 aa)
initn: 1220 init1: 1220 opt: 1220 Z-score: 1481.1 bits: 281.5 E(85289): 9.2e-76
Smith-Waterman score: 1220; 85.0% identity (94.2% similar) in 207 aa overlap (47-253:32-238)
20 30 40 50 60 70
pF1KE6 NQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVLKRAIRTLWAILDGTDQ
:: .:::::.::: ::::::::..::. ::
NP_001 RHRYLASDCSPSFLPSLYHPSQMKQNAGQSDAGYEFDICFTSVQKRAIRTLWTVLDAIDQ
10 20 30 40 50 60
80 90 100 110 120 130
pF1KE6 MWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEEQVKIWRRSFDIPPPPMDEKHPYYNSI
::::::::::::::::::::::::::::::::: ::::::::.:.:::::. ::.:..:
NP_001 MWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEAQVKIWRRSYDVPPPPMEPDHPFYSNI
70 80 90 100 110 120
140 150 160 170 180 190
pF1KE6 SKERRYAGLKPGELPTCESLKDTIARALPFWNEEIVPQIKAGKRVLIAAHGNSLRGIVKH
::.:::: : .::.:::::::::::::::::::::::: :::::::::::::::::::
NP_001 SKDRRYADLTEDQLPSCESLKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLRGIVKH
130 140 150 160 170 180
200 210 220 230 240 250
pF1KE6 LEGMSDQAIMELNLPTGIPIVYELNKELKPTKPMQFLGDEETVRKAMEAVAAQGKAK
:::.:..:::::::::::::::::.:.::: ::::::::::::::::::::::::::
NP_001 LEGLSEEAIMELNLPTGIPIVYELDKNLKPIKPMQFLGDEETVRKAMEAVAAQGKAKK
190 200 210 220 230
>>NP_001280014 (OMIM: 222800,613896) bisphosphoglycerate (259 aa)
initn: 985 init1: 597 opt: 978 Z-score: 1187.8 bits: 227.4 E(85289): 2e-59
Smith-Waterman score: 978; 51.4% identity (80.4% similar) in 255 aa overlap (1-253:1-255)
10 20 30 40 50 60
pF1KE6 MATHRLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVL
:. ..:.:.::::..::.:::::.: : .:. .: :::. .: .: ..:::. .::::
NP_001 MSKYKLIMLRHGEGAWNKENRFCSWVDQKLNSEGMEEARNCGKQLKALNFEFDLVFTSVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 KRAIRTLWAILDGTDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEEQVKIWRRSFD
.:.:.: : ::. : :.:: .:::::::::.: :::. . : .::::::..::::..
NP_001 NRSIHTAWLILEELGQEWVPVESSWRLNERHYGALIGLNREQMALNHGEEQVRLWRRSYN
70 80 90 100 110 120
130 140 150 160 170
pF1KE6 IPPPPMDEKHPYYNSISKERRYA--GLKPGELPTCESLKDTIARALPFWNEEIVPQIKAG
. :::..:.::::. : ..::: . .:: :::::.. : ::.:::.:.:.. :
NP_001 VTPPPIEESHPYYQEIYNDRRYKVCDVPLDQLPRSESLKDVLERLLPYWNERIAPEVLRG
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE6 KRVLIAAHGNSLRGIVKHLEGMSDQAIMELNLPTGIPIVYELNKELKPTKPMQFLGDEET
: .::.::::: :...:::::.::. :....::::.::. ::...:. . : :::::.:.
NP_001 KTILISAHGNSSRALLKHLEGISDEDIINITLPTGVPILLELDENLRAVGPHQFLGDQEA
190 200 210 220 230 240
240 250
pF1KE6 VRKAMEAVAAQGKAK
.. :.. : :::.:
NP_001 IQAAIKKVEDQGKVKQAKK
250
>>NP_954655 (OMIM: 222800,613896) bisphosphoglycerate mu (259 aa)
initn: 985 init1: 597 opt: 978 Z-score: 1187.8 bits: 227.4 E(85289): 2e-59
Smith-Waterman score: 978; 51.4% identity (80.4% similar) in 255 aa overlap (1-253:1-255)
10 20 30 40 50 60
pF1KE6 MATHRLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVL
:. ..:.:.::::..::.:::::.: : .:. .: :::. .: .: ..:::. .::::
NP_954 MSKYKLIMLRHGEGAWNKENRFCSWVDQKLNSEGMEEARNCGKQLKALNFEFDLVFTSVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 KRAIRTLWAILDGTDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEEQVKIWRRSFD
.:.:.: : ::. : :.:: .:::::::::.: :::. . : .::::::..::::..
NP_954 NRSIHTAWLILEELGQEWVPVESSWRLNERHYGALIGLNREQMALNHGEEQVRLWRRSYN
70 80 90 100 110 120
130 140 150 160 170
pF1KE6 IPPPPMDEKHPYYNSISKERRYA--GLKPGELPTCESLKDTIARALPFWNEEIVPQIKAG
. :::..:.::::. : ..::: . .:: :::::.. : ::.:::.:.:.. :
NP_954 VTPPPIEESHPYYQEIYNDRRYKVCDVPLDQLPRSESLKDVLERLLPYWNERIAPEVLRG
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE6 KRVLIAAHGNSLRGIVKHLEGMSDQAIMELNLPTGIPIVYELNKELKPTKPMQFLGDEET
: .::.::::: :...:::::.::. :....::::.::. ::...:. . : :::::.:.
NP_954 KTILISAHGNSSRALLKHLEGISDEDIINITLPTGVPILLELDENLRAVGPHQFLGDQEA
190 200 210 220 230 240
240 250
pF1KE6 VRKAMEAVAAQGKAK
.. :.. : :::.:
NP_954 IQAAIKKVEDQGKVKQAKK
250
>>XP_011514829 (OMIM: 222800,613896) PREDICTED: bisphosp (259 aa)
initn: 985 init1: 597 opt: 978 Z-score: 1187.8 bits: 227.4 E(85289): 2e-59
Smith-Waterman score: 978; 51.4% identity (80.4% similar) in 255 aa overlap (1-253:1-255)
10 20 30 40 50 60
pF1KE6 MATHRLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVL
:. ..:.:.::::..::.:::::.: : .:. .: :::. .: .: ..:::. .::::
XP_011 MSKYKLIMLRHGEGAWNKENRFCSWVDQKLNSEGMEEARNCGKQLKALNFEFDLVFTSVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 KRAIRTLWAILDGTDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEEQVKIWRRSFD
.:.:.: : ::. : :.:: .:::::::::.: :::. . : .::::::..::::..
XP_011 NRSIHTAWLILEELGQEWVPVESSWRLNERHYGALIGLNREQMALNHGEEQVRLWRRSYN
70 80 90 100 110 120
130 140 150 160 170
pF1KE6 IPPPPMDEKHPYYNSISKERRYA--GLKPGELPTCESLKDTIARALPFWNEEIVPQIKAG
. :::..:.::::. : ..::: . .:: :::::.. : ::.:::.:.:.. :
XP_011 VTPPPIEESHPYYQEIYNDRRYKVCDVPLDQLPRSESLKDVLERLLPYWNERIAPEVLRG
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE6 KRVLIAAHGNSLRGIVKHLEGMSDQAIMELNLPTGIPIVYELNKELKPTKPMQFLGDEET
: .::.::::: :...:::::.::. :....::::.::. ::...:. . : :::::.:.
XP_011 KTILISAHGNSSRALLKHLEGISDEDIINITLPTGVPILLELDENLRAVGPHQFLGDQEA
190 200 210 220 230 240
240 250
pF1KE6 VRKAMEAVAAQGKAK
.. :.. : :::.:
XP_011 IQAAIKKVEDQGKVKQAKK
250
>>NP_001715 (OMIM: 222800,613896) bisphosphoglycerate mu (259 aa)
initn: 985 init1: 597 opt: 978 Z-score: 1187.8 bits: 227.4 E(85289): 2e-59
Smith-Waterman score: 978; 51.4% identity (80.4% similar) in 255 aa overlap (1-253:1-255)
10 20 30 40 50 60
pF1KE6 MATHRLVMVRHGESTWNQENRFCGWFDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSVL
:. ..:.:.::::..::.:::::.: : .:. .: :::. .: .: ..:::. .::::
NP_001 MSKYKLIMLRHGEGAWNKENRFCSWVDQKLNSEGMEEARNCGKQLKALNFEFDLVFTSVL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 KRAIRTLWAILDGTDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEEQVKIWRRSFD
.:.:.: : ::. : :.:: .:::::::::.: :::. . : .::::::..::::..
NP_001 NRSIHTAWLILEELGQEWVPVESSWRLNERHYGALIGLNREQMALNHGEEQVRLWRRSYN
70 80 90 100 110 120
130 140 150 160 170
pF1KE6 IPPPPMDEKHPYYNSISKERRYA--GLKPGELPTCESLKDTIARALPFWNEEIVPQIKAG
. :::..:.::::. : ..::: . .:: :::::.. : ::.:::.:.:.. :
NP_001 VTPPPIEESHPYYQEIYNDRRYKVCDVPLDQLPRSESLKDVLERLLPYWNERIAPEVLRG
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE6 KRVLIAAHGNSLRGIVKHLEGMSDQAIMELNLPTGIPIVYELNKELKPTKPMQFLGDEET
: .::.::::: :...:::::.::. :....::::.::. ::...:. . : :::::.:.
NP_001 KTILISAHGNSSRALLKHLEGISDEDIINITLPTGVPILLELDENLRAVGPHQFLGDQEA
190 200 210 220 230 240
240 250
pF1KE6 VRKAMEAVAAQGKAK
.. :.. : :::.:
NP_001 IQAAIKKVEDQGKVKQAKK
250
>>NP_065108 (OMIM: 610775) fructose-2,6-bisphosphatase T (270 aa)
initn: 118 init1: 68 opt: 140 Z-score: 173.4 bits: 39.7 E(85289): 0.0064
Smith-Waterman score: 160; 25.3% identity (54.1% similar) in 257 aa overlap (1-227:1-251)
10 20 30 40 50
pF1KE6 MATHRLVMVRHGESTWNQENRFCGW-FDAELSEKGTEEAKRGAKAIKDAKMEFDICYTSV
:: :..:::::. .:.:. . : : ::: : ..: .: .: ...: ..:
NP_065 MARFALTVVRHGETRFNKEKIIQGQGVDEPLSETGFKQA--AAAGIFLNNVKFTHAFSSD
10 20 30 40 50
60 70 80 90 100 110
pF1KE6 LKRAIRTLWAILDGTDQMW-LPVVRTWRLNERHYGGLTG--LNKAETAAKHGEEQVKIWR
: :. .:. .::. . . : :: ::.:: . : :.. .. :: ..:. ..
NP_065 LMRTKQTMHGILERSKFCKDMTVKYDSRLRERKYGVVEGKALSELRAMAKAAREECPVFT
60 70 80 90 100 110
120 130 140 150 160
pF1KE6 ----RSFD-IPPPPMDEKHPYYNSISKER-RYAGLKPGELPTCESLKDTIARALPFW---
...: . .: . . : :: . .. : .: :. ..:. .:.
NP_065 PPGGETLDQVKMRGIDFFEFLCQLILKEADQKEQFSQGSPSNC--LETSLAEIFPLGKNH
120 130 140 150 160 170
170 180 190 200 210
pF1KE6 -----NEEIVPQIKAGKRVLIAAHGNSLRGIVKHL---------EGMSDQAIMELNLPTG
.. .: . :. ::...:: .:.. .. .: . .: .. ::
NP_065 SSKVNSDSGIPGLAAS--VLVVSHGAYMRSLFDYFLTDLKCSLPATLSRSELMSVTPNTG
180 190 200 210 220 230
220 230 240 250
pF1KE6 IP---IVYELNKELKPTKPMQFLGDEETVRKAMEAVAAQGKAK
. : .: ..:.:::
NP_065 MSLFIINFEEGREVKPTVQCICMNLQDHLNGLTETR
240 250 260 270
253 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 15:10:09 2016 done: Tue Nov 8 15:10:10 2016
Total Scan time: 5.970 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]