Result of FASTA (omim) for
pFN21AE6634
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6634, 216 aa
1>>>pF1KE6634 216 - 216 aa - 216 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.0959+/-0.000347; mu= 15.1737+/- 0.022
mean_var=65.1467+/-12.971, 0's: 0 Z-trim(113.9): 51 B-trim: 24 in 1/51
Lambda= 0.158902
statistics sampled from 23364 (23416) to 23364 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.667), E-opt: 0.2 (0.275), width: 16
Scan time: 5.000
The best scores are: opt bits E(85289)
NP_665877 (OMIM: 603758) maleylacetoacetate isomer ( 216) 1428 335.8 3.2e-92
NP_001299589 (OMIM: 603758) maleylacetoacetate iso ( 161) 1056 250.5 1.2e-66
XP_016876732 (OMIM: 603758) PREDICTED: maleylaceto ( 177) 947 225.5 4.3e-59
XP_011534972 (OMIM: 603758) PREDICTED: maleylaceto ( 177) 947 225.5 4.3e-59
NP_665878 (OMIM: 603758) maleylacetoacetate isomer ( 174) 683 165.0 7e-41
XP_011534973 (OMIM: 603758) PREDICTED: maleylaceto ( 175) 683 165.0 7.1e-41
NP_004823 (OMIM: 605482) glutathione S-transferase ( 241) 216 58.0 1.5e-08
NP_001177932 (OMIM: 605482) glutathione S-transfer ( 213) 212 57.0 2.6e-08
NP_000838 (OMIM: 605449) glutathione S-transferase ( 222) 208 56.1 5.2e-08
NP_899062 (OMIM: 612314) glutathione S-transferase ( 243) 186 51.1 1.8e-06
XP_011537572 (OMIM: 612314) PREDICTED: glutathione ( 243) 186 51.1 1.8e-06
NP_665683 (OMIM: 138359) glutathione S-transferase ( 222) 184 50.6 2.3e-06
NP_001177943 (OMIM: 612314) glutathione S-transfer ( 215) 182 50.2 3.1e-06
NP_000837 (OMIM: 138360) glutathione S-transferase ( 222) 181 50.0 3.8e-06
XP_011512834 (OMIM: 138360) PREDICTED: glutathione ( 222) 181 50.0 3.8e-06
NP_714543 (OMIM: 607605) glutathione S-transferase ( 222) 179 49.5 5.2e-06
NP_001177931 (OMIM: 605482) glutathione S-transfer ( 208) 178 49.2 5.7e-06
XP_005249091 (OMIM: 138359) PREDICTED: glutathione ( 225) 168 47.0 3e-05
XP_006715135 (OMIM: 605449) PREDICTED: glutathione ( 172) 166 46.4 3.3e-05
XP_016866283 (OMIM: 605449) PREDICTED: glutathione ( 172) 166 46.4 3.3e-05
XP_006717687 (OMIM: 612314) PREDICTED: glutathione ( 183) 159 44.9 0.00011
XP_011537575 (OMIM: 612314) PREDICTED: glutathione ( 149) 153 43.4 0.00023
XP_005249092 (OMIM: 605450) PREDICTED: glutathione ( 222) 152 43.3 0.00038
NP_001503 (OMIM: 605450) glutathione S-transferase ( 222) 152 43.3 0.00038
XP_011537573 (OMIM: 612314) PREDICTED: glutathione ( 166) 150 42.8 0.00041
XP_011537574 (OMIM: 612314) PREDICTED: glutathione ( 166) 150 42.8 0.00041
XP_016871160 (OMIM: 612314) PREDICTED: glutathione ( 132) 148 42.2 0.00047
XP_016871159 (OMIM: 612314) PREDICTED: glutathione ( 132) 148 42.2 0.00047
NP_000844 (OMIM: 600436) glutathione S-transferase ( 240) 151 43.1 0.00047
NP_000845 (OMIM: 600437) glutathione S-transferase ( 244) 151 43.1 0.00048
NP_001177942 (OMIM: 612314) glutathione S-transfer ( 209) 149 42.6 0.00058
NP_001177944 (OMIM: 612314) glutathione S-transfer ( 181) 145 41.6 0.00097
XP_011512837 (OMIM: 605450) PREDICTED: glutathione ( 185) 144 41.4 0.0012
XP_011512836 (OMIM: 605450) PREDICTED: glutathione ( 185) 144 41.4 0.0012
NP_001289599 (OMIM: 600437) glutathione S-transfer ( 230) 141 40.8 0.0022
>>NP_665877 (OMIM: 603758) maleylacetoacetate isomerase (216 aa)
initn: 1428 init1: 1428 opt: 1428 Z-score: 1776.6 bits: 335.8 E(85289): 3.2e-92
Smith-Waterman score: 1428; 100.0% identity (100.0% similar) in 216 aa overlap (1-216:1-216)
10 20 30 40 50 60
pF1KE6 MQAGKPILYSYFRSSCSWRVRIALALKGIDYETVPINLIKDGGQQFSKDFQALNPMKQVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 MQAGKPILYSYFRSSCSWRVRIALALKGIDYETVPINLIKDGGQQFSKDFQALNPMKQVP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 TLKIDGITIHQSLAIIEYLEEMRPTPRLLPQDPKKRASVRMISDLIAGGIQPLQNLSVLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 TLKIDGITIHQSLAIIEYLEEMRPTPRLLPQDPKKRASVRMISDLIAGGIQPLQNLSVLK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 QVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMADLCLVPQVANAERFKVDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 QVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMADLCLVPQVANAERFKVDL
130 140 150 160 170 180
190 200 210
pF1KE6 TPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA
::::::::::::::::::::::::::::::::::::
NP_665 TPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA
190 200 210
>>NP_001299589 (OMIM: 603758) maleylacetoacetate isomera (161 aa)
initn: 1056 init1: 1056 opt: 1056 Z-score: 1317.5 bits: 250.5 E(85289): 1.2e-66
Smith-Waterman score: 1056; 100.0% identity (100.0% similar) in 161 aa overlap (56-216:1-161)
30 40 50 60 70 80
pF1KE6 LKGIDYETVPINLIKDGGQQFSKDFQALNPMKQVPTLKIDGITIHQSLAIIEYLEEMRPT
::::::::::::::::::::::::::::::
NP_001 MKQVPTLKIDGITIHQSLAIIEYLEEMRPT
10 20 30
90 100 110 120 130 140
pF1KE6 PRLLPQDPKKRASVRMISDLIAGGIQPLQNLSVLKQVGEEMQLTWAQNAITCGFNALEQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PRLLPQDPKKRASVRMISDLIAGGIQPLQNLSVLKQVGEEMQLTWAQNAITCGFNALEQI
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE6 LQSTAGIYCVGDEVTMADLCLVPQVANAERFKVDLTPYPTISSINKRLLVLEAFQVSHPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQSTAGIYCVGDEVTMADLCLVPQVANAERFKVDLTPYPTISSINKRLLVLEAFQVSHPC
100 110 120 130 140 150
210
pF1KE6 RQPDTPTELRA
:::::::::::
NP_001 RQPDTPTELRA
160
>>XP_016876732 (OMIM: 603758) PREDICTED: maleylacetoacet (177 aa)
initn: 947 init1: 947 opt: 947 Z-score: 1181.9 bits: 225.5 E(85289): 4.3e-59
Smith-Waterman score: 947; 100.0% identity (100.0% similar) in 144 aa overlap (73-216:34-177)
50 60 70 80 90 100
pF1KE6 GQQFSKDFQALNPMKQVPTLKIDGITIHQSLAIIEYLEEMRPTPRLLPQDPKKRASVRMI
::::::::::::::::::::::::::::::
XP_016 EEEKEEFAGPVPSGPGVLGPLPASLLPSGQLAIIEYLEEMRPTPRLLPQDPKKRASVRMI
10 20 30 40 50 60
110 120 130 140 150 160
pF1KE6 SDLIAGGIQPLQNLSVLKQVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SDLIAGGIQPLQNLSVLKQVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMA
70 80 90 100 110 120
170 180 190 200 210
pF1KE6 DLCLVPQVANAERFKVDLTPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLCLVPQVANAERFKVDLTPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA
130 140 150 160 170
>>XP_011534972 (OMIM: 603758) PREDICTED: maleylacetoacet (177 aa)
initn: 947 init1: 947 opt: 947 Z-score: 1181.9 bits: 225.5 E(85289): 4.3e-59
Smith-Waterman score: 947; 100.0% identity (100.0% similar) in 144 aa overlap (73-216:34-177)
50 60 70 80 90 100
pF1KE6 GQQFSKDFQALNPMKQVPTLKIDGITIHQSLAIIEYLEEMRPTPRLLPQDPKKRASVRMI
::::::::::::::::::::::::::::::
XP_011 EEEKEEFAGPVPSGPGVLGPLPASLLPSGQLAIIEYLEEMRPTPRLLPQDPKKRASVRMI
10 20 30 40 50 60
110 120 130 140 150 160
pF1KE6 SDLIAGGIQPLQNLSVLKQVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SDLIAGGIQPLQNLSVLKQVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMA
70 80 90 100 110 120
170 180 190 200 210
pF1KE6 DLCLVPQVANAERFKVDLTPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLCLVPQVANAERFKVDLTPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA
130 140 150 160 170
>>NP_665878 (OMIM: 603758) maleylacetoacetate isomerase (174 aa)
initn: 1141 init1: 674 opt: 683 Z-score: 854.9 bits: 165.0 E(85289): 7e-41
Smith-Waterman score: 1061; 80.6% identity (80.6% similar) in 216 aa overlap (1-216:1-174)
10 20 30 40 50 60
pF1KE6 MQAGKPILYSYFRSSCSWRVRIALALKGIDYETVPINLIKDGGQQFSKDFQALNPMKQVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 MQAGKPILYSYFRSSCSWRVRIALALKGIDYETVPINLIKDGGQQFSKDFQALNPMKQVP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 TLKIDGITIHQSLAIIEYLEEMRPTPRLLPQDPKKRASVRMISDLIAGGIQPLQNLSVLK
:::::::::::: ::::::
NP_665 TLKIDGITIHQS------------------------------------------NLSVLK
70
130 140 150 160 170 180
pF1KE6 QVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMADLCLVPQVANAERFKVDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_665 QVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMADLCLVPQVANAERFKVDL
80 90 100 110 120 130
190 200 210
pF1KE6 TPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA
::::::::::::::::::::::::::::::::::::
NP_665 TPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA
140 150 160 170
>>XP_011534973 (OMIM: 603758) PREDICTED: maleylacetoacet (175 aa)
initn: 1125 init1: 674 opt: 683 Z-score: 854.9 bits: 165.0 E(85289): 7.1e-41
Smith-Waterman score: 1045; 79.5% identity (80.5% similar) in 215 aa overlap (2-216:3-175)
10 20 30 40 50
pF1KE6 MQAGKPILYSYFRSSCSWRVRIALALKGIDYETVPINLIKDGGQQFSKDFQALNPMKQV
..::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MTESGKPILYSYFRSSCSWRVRIALALKGIDYETVPINLIKDGGQQFSKDFQALNPMKQV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 PTLKIDGITIHQSLAIIEYLEEMRPTPRLLPQDPKKRASVRMISDLIAGGIQPLQNLSVL
::::::::::::: :::::
XP_011 PTLKIDGITIHQS------------------------------------------NLSVL
70
120 130 140 150 160 170
pF1KE6 KQVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMADLCLVPQVANAERFKVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KQVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMADLCLVPQVANAERFKVD
80 90 100 110 120 130
180 190 200 210
pF1KE6 LTPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA
:::::::::::::::::::::::::::::::::::::
XP_011 LTPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA
140 150 160 170
>>NP_004823 (OMIM: 605482) glutathione S-transferase ome (241 aa)
initn: 167 init1: 96 opt: 216 Z-score: 274.3 bits: 58.0 E(85289): 1.5e-08
Smith-Waterman score: 216; 29.9% identity (55.4% similar) in 184 aa overlap (4-182:22-197)
10 20 30 40
pF1KE6 MQAGKPILYSYFRSSCSWRVRIALALKGIDYETVPINLIKDG
:. .::. . :.:..: ::: .:.. ::: :.
NP_004 MSGESARSLGKGSAPPGPVPEGSIRIYSMRFCPFAERTRLVLKAKGIRHEVININL-KNK
10 20 30 40 50
50 60 70 80 90 100
pF1KE6 GQQFSKDFQALNPMKQVPTLKID-GITIHQSLAIIEYLEEMRPTPRLLPQDPKKRASVRM
. : : ::. ::.:. . : :..: :::.: : .:::.:: ..: .:
NP_004 PEWFFKK----NPFGLVPVLENSQGQLIYESAITCEYLDEAYPGKKLLPDDPYEKACQKM
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE6 ISDLIAGGIQPLQNLSVLKQVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTM
: .:.. . : . . .: :.. . .. . :. ::..: . . :. ..:
NP_004 ILELFSK-VPSLVGSFIRSQNKEDY--AGLKEEFRKEFTKLEEVLTNKKTTFFGGNSISM
120 130 140 150 160 170
170 180 190 200 210
pF1KE6 ADLCLVPQVANAERFK----VDLTPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA
: . : : .: :: ::
NP_004 IDYLIWPWFERLEAMKLNECVDHTPKLKLWMAAMKEDPTVSALLTSEKDWQGFLELYLQN
180 190 200 210 220 230
>>NP_001177932 (OMIM: 605482) glutathione S-transferase (213 aa)
initn: 164 init1: 96 opt: 212 Z-score: 270.1 bits: 57.0 E(85289): 2.6e-08
Smith-Waterman score: 212; 30.8% identity (56.2% similar) in 169 aa overlap (19-182:9-169)
10 20 30 40 50 60
pF1KE6 MQAGKPILYSYFRSSCSWRVRIALALKGIDYETVPINLIKDGGQQFSKDFQALNPMKQVP
:.:..: ::: .:.. ::: :. . : : ::. ::
NP_001 MRFCPFAERTRLVLKAKGIRHEVININL-KNKPEWFFKK----NPFGLVP
10 20 30 40
70 80 90 100 110
pF1KE6 TLKID-GITIHQSLAIIEYLEEMRPTPRLLPQDPKKRASVRMISDLIAGGIQPLQNLSVL
.:. . : :..: :::.: : .:::.:: ..: .:: .:.. . : . .
NP_001 VLENSQGQLIYESAITCEYLDEAYPGKKLLPDDPYEKACQKMILELFSK-VPSLVGSFIR
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE6 KQVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTMADLCLVPQVANAERFK--
.: :.. . .. . :. ::..: . . :. ..: : . : : .:
NP_001 SQNKEDY--AGLKEEFRKEFTKLEEVLTNKKTTFFGGNSISMIDYLIWPWFERLEAMKLN
110 120 130 140 150 160
180 190 200 210
pF1KE6 --VDLTPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA
:: ::
NP_001 ECVDHTPKLKLWMAAMKEDPTVSALLTSEKDWQGFLELYLQNSPEACDYGL
170 180 190 200 210
>>NP_000838 (OMIM: 605449) glutathione S-transferase A3 (222 aa)
initn: 158 init1: 80 opt: 208 Z-score: 264.9 bits: 56.1 E(85289): 5.2e-08
Smith-Waterman score: 208; 26.2% identity (57.9% similar) in 221 aa overlap (3-216:2-212)
10 20 30 40 50
pF1KE6 MQAGKPILYSYFRSSCSWR-VRIALALKGIDYETVPINLIKDGGQQFSKDFQALNPMKQV
:::: :. :: . . .: :: :...: :. .: :. . .: . . ..::
NP_000 MAGKPKLH-YFNGRGRMEPIRWLLAAAGVEFEEKFIGSAEDLGK-LRNDGSLM--FQQV
10 20 30 40 50
60 70 80 90 100 110
pF1KE6 PTLKIDGITIHQSLAIIEYLEEMRPTPRLLPQDPKKRASVRMISDLIAGGIQPLQNLSVL
: ..:::. . :. ::..:. : .: :.:: . : .. .: . . : .
NP_000 PMVEIDGMKLVQTRAILNYIASKY---NLYGKDIKERALIDMYTEGMADLNEMILLLPLC
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE6 KQVGEEMQLTWAQNAITCG-FNALEQILQSTAGIYCVGDEVTMADLCLVPQVANAERFKV
. .. ... .. : :.:..::: . : ::.... ::. :: . .:..
NP_000 RPEEKDAKIALIKEKTKSRYFPAFEKVLQSHGQDYLVGNKLSRADISLVELLYYVEELDS
120 130 140 150 160 170
180 190 200 210
pF1KE6 DL-TPYPTISSINKRL----LVLEAFQVSHPCRQPDTPTELRA
.: . .: ..... :. : . .: . : :.: :.. .:
NP_000 SLISNFPLLKALKTRISNLPTVKKFLQPGSP-RKP--PADAKALEEARKIFRF
180 190 200 210 220
>>NP_899062 (OMIM: 612314) glutathione S-transferase ome (243 aa)
initn: 85 init1: 85 opt: 186 Z-score: 237.0 bits: 51.1 E(85289): 1.8e-06
Smith-Waterman score: 186; 28.4% identity (54.3% similar) in 162 aa overlap (8-168:26-180)
10 20 30 40
pF1KE6 MQAGKPILYSYFRSSCSWRVRIALALKGIDYETVPINLIKDG
.::. : :.:..: : : .:.: ::: .
NP_899 MSGDATRTLGKGSQPPGPVPEGLIRIYSMRFCPYSHRTRLVLKAKDIRHEVVNINLRNKP
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE6 GQQFSKDFQALNPMKQVPTLKIDGIT-IHQSLAIIEYLEEMRPTPRLLPQDPKKRASVRM
..: .:. ..:.:. . :..:. :::.. : .:.: :: .:: .:
NP_899 EWYYTK-----HPFGHIPVLETSQCQLIYESVIACEYLDDAYPGRKLFPYDPYERARQKM
70 80 90 100 110
110 120 130 140 150 160
pF1KE6 ISDLIAGGIQPLQNLSVLKQVGEEMQLTWAQNAITCGFNALEQILQSTAGIYCVGDEVTM
. .:. . .. : . :.: : . :. :. ::.::. . : ..:
NP_899 LLELFCKVPHLTKECLVALRCGRE--CTNLKAALRQEFSNLEEILEYQNTTFFGGTCISM
120 130 140 150 160 170
170 180 190 200 210
pF1KE6 ADLCLVPQVANAERFKVDLTPYPTISSINKRLLVLEAFQVSHPCRQPDTPTELRA
: : :
NP_899 IDYLLWPWFERLDVYGILDCVSHTPALRLWISAMKWDPTVCALLMDKSIFQGFLNLYFQN
180 190 200 210 220 230
216 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 14:58:13 2016 done: Tue Nov 8 14:58:14 2016
Total Scan time: 5.000 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]