FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE6627, 220 aa
  1>>>pF1KE6627 220 - 220 aa - 220 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.5451+/-0.000334; mu= 12.1102+/- 0.021
 mean_var=63.5235+/-12.380, 0's: 0 Z-trim(115.2): 6  B-trim: 6 in 1/51
 Lambda= 0.160919
 statistics sampled from 25491 (25497) to 25491 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.687), E-opt: 0.2 (0.299), width:  16
 Scan time:  4.250

The best scores are:                                      opt bits E(85289)
NP_003246 (OMIM: 188825) metalloproteinase inhibit ( 220) 1538 365.4  4e-101
NP_003247 (OMIM: 601915) metalloproteinase inhibit ( 224)  780 189.5 3.9e-48
NP_000353 (OMIM: 136900,188826) metalloproteinase  ( 211)  686 167.6 1.4e-41
NP_003245 (OMIM: 305370) metalloproteinase inhibit ( 207)  554 137.0 2.2e-32
XP_016885255 (OMIM: 305370) PREDICTED: metalloprot ( 261)  154 44.2 0.00025


>>NP_003246 (OMIM: 188825) metalloproteinase inhibitor 2  (220 aa)
 initn: 1538 init1: 1538 opt: 1538  Z-score: 1936.4  bits: 365.4 E(85289): 4e-101
Smith-Waterman score: 1538; 100.0% identity (100.0% similar) in 220 aa overlap (1-220:1-220)

               10        20        30        40        50        60
pF1KE6 MGAAARTLRLALGLLLLATLLRPADACSCSPVHPQQAFCNADVVIRAKAVSEKEVDSGND
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MGAAARTLRLALGLLLLATLLRPADACSCSPVHPQQAFCNADVVIRAKAVSEKEVDSGND
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE6 IYGNPIKRIQYEIKQIKMFKGPEKDIEFIYTAPSSAVCGVSLDVGGKKEYLIAGKAEGDG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 IYGNPIKRIQYEIKQIKMFKGPEKDIEFIYTAPSSAVCGVSLDVGGKKEYLIAGKAEGDG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE6 KMHITLCDFIVPWDTLSTTQKKSLNHRYQMGCECKITRCPMIPCYISSPDECLWMDWVTE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 KMHITLCDFIVPWDTLSTTQKKSLNHRYQMGCECKITRCPMIPCYISSPDECLWMDWVTE
              130       140       150       160       170       180

              190       200       210       220
pF1KE6 KNINGHQAKFFACIKRSDGSCAWYRGAAPPKQEFLDIEDP
       ::::::::::::::::::::::::::::::::::::::::
NP_003 KNINGHQAKFFACIKRSDGSCAWYRGAAPPKQEFLDIEDP
              190       200       210       220

>>NP_003247 (OMIM: 601915) metalloproteinase inhibitor 4  (224 aa)
 initn: 812 init1: 564 opt: 780  Z-score: 985.2  bits: 189.5 E(85289): 3.9e-48
Smith-Waterman score: 780; 50.0% identity (80.2% similar) in 212 aa overlap (14-220:14-224)

               10        20           30        40        50       
pF1KE6 MGAAARTLRLALGLLLLATLLRP---ADACSCSPVHPQQAFCNADVVIRAKAVSEKEVDS
                    :: : .::::   ..::::.:.:::: .:.. .:::::  ::: : .
NP_003 MPGSPRPAPSWVLLLRLLALLRPPGLGEACSCAPAHPQQHICHSALVIRAKISSEKVVPA
               10        20        30        40        50        60

        60        70        80          90       100       110     
pF1KE6 GNDIYGNPIKRIQYEIKQIKMFKGPEK--DIEFIYTAPSSAVCGVSLDVGGKKEYLIAGK
       . :  ..  : ..::::::::::: ::  :...:::  .:..:::.:.....:.::..:.
NP_003 SADP-ADTEKMLRYEIKQIKMFKGFEKVKDVQYIYTPFDSSLCGVKLEANSQKQYLLTGQ
                70        80        90       100       110         

         120       130       140       150       160       170     
pF1KE6 AEGDGKMHITLCDFIVPWDTLSTTQKKSLNHRYQMGCECKITRCPMIPCYISSPDECLWM
       . .:::. : ::..: ::. :: .:..::::.:...: :.:: :  .:: ::.:.:::: 
NP_003 VLSDGKVFIHLCNYIEPWEDLSLVQRESLNHHYHLNCGCQITTCYTVPCTISAPNECLWT
     120       130       140       150       160       170         

         180       190       200       210       220
pF1KE6 DWVTEKNINGHQAKFFACIKRSDGSCAWYRGAAPPKQEFLDIEDP
       ::. :... :.::. ..:.:. ::.:.::::  : ..::.:: .:
NP_003 DWLLERKLYGYQAQHYVCMKHVDGTCSWYRGHLPLRKEFVDIVQP
     180       190       200       210       220    

>>NP_000353 (OMIM: 136900,188826) metalloproteinase inhi  (211 aa)
 initn: 616 init1: 456 opt: 686  Z-score: 867.7  bits: 167.6 E(85289): 1.4e-41
Smith-Waterman score: 686; 45.2% identity (75.4% similar) in 199 aa overlap (24-220:21-211)

               10        20        30        40        50        60
pF1KE6 MGAAARTLRLALGLLLLATLLRPADACSCSPVHPQQAFCNADVVIRAKAVSEKEVDSGND
                              :.::.::: :::.::::.:.:::::.:..: :  :  
NP_000    MTPWLGLIVLLGSWSLGDWGAEACTCSPSHPQDAFCNSDIVIRAKVVGKKLVKEG--
                  10        20        30        40        50       

               70        80          90       100       110        
pF1KE6 IYGNPIKRIQYEIKQIKMFKGPEK--DIEFIYTAPSSAVCGVSLDVGGKKEYLIAGKAEG
           :.  . : :::.::..:  :   ...:.:  : ..::..:.:. : .::..:..  
NP_000 ----PFGTLVYTIKQMKMYRGFTKMPHVQYIHTEASESLCGLKLEVN-KYQYLLTGRVY-
              60        70        80        90        100          

      120       130       140       150       160       170        
pF1KE6 DGKMHITLCDFIVPWDTLSTTQKKSLNHRYQMGCECKITRCPMIPCYISSPDECLWMDWV
       ::::.  ::.:.  :: :. .:.:.::.::..::.:::  : ..::...: .:::: : .
NP_000 DGKMYTGLCNFVERWDQLTLSQRKGLNYRYHLGCNCKIKSCYYLPCFVTSKNECLWTDML
     110       120       130       140       150       160         

      180       190       200       210       220
pF1KE6 TEKNINGHQAKFFACIKRSDGSCAWYRGAAPPKQEFLDIEDP
       .. .  :.:.: .:::... : :.:::: ::: . ...  ::
NP_000 SNFGYPGYQSKHYACIRQKGGYCSWYRGWAPPDKSIINATDP
     170       180       190       200       210 

>>NP_003245 (OMIM: 305370) metalloproteinase inhibitor 1  (207 aa)
 initn: 547 init1: 199 opt: 554  Z-score: 702.2  bits: 137.0 E(85289): 2.2e-32
Smith-Waterman score: 554; 42.3% identity (67.2% similar) in 201 aa overlap (10-203:7-199)

               10        20        30        40        50        60
pF1KE6 MGAAARTLRLALGLLLLATLLRPADACSCSPVHPQQAFCNADVVIRAKAVSEKEVDSGND
                :: :.:::  :. :. ::.: : ::: ::::.:.::::: :.  ::.. . 
NP_003    MAPFEPLASGILLLLWLIAPSRACTCVPPHPQTAFCNSDLVIRAKFVGTPEVNQ-TT
                  10        20        30        40        50       

               70        80             90       100        110    
pF1KE6 IYGNPIKRIQYEIKQIKMFKGPEK-----DIEFIYTAPSSAVCGVSLDVGGK-KEYLIAG
       .:       .::::. ::.:: .      ::.:.::    .:::      .. .:.::::
NP_003 LYQ------RYEIKMTKMYKGFQALGDAADIRFVYTPAMESVCGYFHRSHNRSEEFLIAG
               60        70        80        90       100       110

          120       130       140       150        160       170   
pF1KE6 KAEGDGKMHITLCDFIVPWDTLSTTQKKSLNHRYQMGCE-CKITRCPMIPCYISSPDECL
       : . :: .::: :.:..::..:: .:...... : .::: : .  :  ::: ..:  .::
NP_003 KLQ-DGLLHITTCSFVAPWNSLSLAQRRGFTKTYTVGCEECTVFPCLSIPCKLQSGTHCL
               120       130       140       150       160         

           180       190       200       210       220
pF1KE6 WMDWVTEKNINGHQAKFFACIKRSDGSCAWYRGAAPPKQEFLDIEDP
       : : . . . .: :.. .::. :  : :.:                 
NP_003 WTDQLLQGSEKGFQSRHLACLPREPGLCTWQSLRSQIA         
     170       180       190       200                

>>XP_016885255 (OMIM: 305370) PREDICTED: metalloproteina  (261 aa)
 initn: 184 init1: 146 opt: 154  Z-score: 198.7  bits: 44.2 E(85289): 0.00025
Smith-Waterman score: 154; 42.2% identity (80.0% similar) in 45 aa overlap (114-157:104-147)

            90       100       110       120       130       140   
pF1KE6 KDIEFIYTAPSSAVCGVSLDVGGKKEYLIAGKAEGDGKMHITLCDFIVPWDTLSTTQKKS
                                     :: . :: .::: :.:..::..:: .:...
XP_016 FSLSEGRAFGSLAAQPITSCLSVPAPPFSLGKLQ-DGLLHITTCSFVAPWNSLSLAQRRG
            80        90       100        110       120       130  

           150        160       170       180       190       200  
pF1KE6 LNHRYQMGCE-CKITRCPMIPCYISSPDECLWMDWVTEKNINGHQAKFFACIKRSDGSCA
       ... : .::: : ..                                             
XP_016 FTKTYTVGCEECTVSAWTLTSNGRSFPGPFPKSWACFLLPLAILCPCGCSPTLRAVPDLS
            140       150       160       170       180       190  




220 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Tue Nov  8 14:55:05 2016 done: Tue Nov  8 14:55:05 2016
 Total Scan time:  4.250 Total Display time: -0.020

Function used was FASTA [36.3.4 Apr, 2011]