Result of FASTA (omim) for
pFN21AE6619
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6619, 271 aa
1>>>pF1KE6619 271 - 271 aa - 271 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3423+/-0.00036; mu= 14.8788+/- 0.022
mean_var=69.5010+/-13.830, 0's: 0 Z-trim(113.3): 11 B-trim: 0 in 0/55
Lambda= 0.153843
statistics sampled from 22562 (22567) to 22562 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.657), E-opt: 0.2 (0.265), width: 16
Scan time: 4.850
The best scores are: opt bits E(85289)
NP_689958 (OMIM: 604639) neurexophilin-1 precursor ( 271) 1854 420.5 1.7e-117
NP_009157 (OMIM: 604635) neurexophilin-2 precursor ( 264) 1107 254.7 1.3e-67
NP_009156 (OMIM: 604636) neurexophilin-3 precursor ( 252) 847 196.9 3e-50
NP_009155 (OMIM: 604637) neurexophilin-4 precursor ( 308) 423 102.9 7.6e-22
XP_016874236 (OMIM: 604637) PREDICTED: neurexophil ( 223) 202 53.8 3.4e-07
>>NP_689958 (OMIM: 604639) neurexophilin-1 precursor [Ho (271 aa)
initn: 1854 init1: 1854 opt: 1854 Z-score: 2230.5 bits: 420.5 E(85289): 1.7e-117
Smith-Waterman score: 1854; 100.0% identity (100.0% similar) in 271 aa overlap (1-271:1-271)
10 20 30 40 50 60
pF1KE6 MQAACWYVLFLLQPTVYLVTCANLTNGGKSELLKSGSSKSTLKHIWTESSKDLSISRLLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 MQAACWYVLFLLQPTVYLVTCANLTNGGKSELLKSGSSKSTLKHIWTESSKDLSISRLLS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 QTFRGKENDTDLDLRYDTPEPYSEQDLWDWLRNSTDLQEPRPRAKRRPIVKTGKFKKMFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 QTFRGKENDTDLDLRYDTPEPYSEQDLWDWLRNSTDLQEPRPRAKRRPIVKTGKFKKMFG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 WGDFHSNIKTVKLNLLITGKIVDHGNGTFSVYFRHNSTGQGNVSVSLVPPTKIVEFDLAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 WGDFHSNIKTVKLNLLITGKIVDHGNGTFSVYFRHNSTGQGNVSVSLVPPTKIVEFDLAQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 QTVIDAKDSKSFNCRIEYEKVDKATKNTLCNYDPSKTCYQEQTQSHVSWLCSKPFKVICI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 QTVIDAKDSKSFNCRIEYEKVDKATKNTLCNYDPSKTCYQEQTQSHVSWLCSKPFKVICI
190 200 210 220 230 240
250 260 270
pF1KE6 YISFYSTDYKLVQKVCPDYNYHSDTPYFPSG
:::::::::::::::::::::::::::::::
NP_689 YISFYSTDYKLVQKVCPDYNYHSDTPYFPSG
250 260 270
>>NP_009157 (OMIM: 604635) neurexophilin-2 precursor [Ho (264 aa)
initn: 1106 init1: 1106 opt: 1107 Z-score: 1334.6 bits: 254.7 E(85289): 1.3e-67
Smith-Waterman score: 1107; 79.0% identity (93.3% similar) in 195 aa overlap (79-271:70-264)
50 60 70 80 90 100
pF1KE6 SSKDLSISRLLSQTFRGKENDTDLDLRYDTPEPYSE--QDLWDWLRNSTDLQEPRPRAKR
: :.. ...:::: : :..::: :.::
NP_009 PGTLVGNVVHSRIISPLRLFVKQSPVPKPGPMAYADSMENFWDWLANITEIQEPLARTKR
40 50 60 70 80 90
110 120 130 140 150 160
pF1KE6 RPIVKTGKFKKMFGWGDFHSNIKTVKLNLLITGKIVDHGNGTFSVYFRHNSTGQGNVSVS
::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::
NP_009 RPIVKTGKFKKMFGWGDFHSNIKTVKLNLLITGKIVDHGNGTFSVYFRHNSTGLGNVSVS
100 110 120 130 140 150
170 180 190 200 210 220
pF1KE6 LVPPTKIVEFDLAQQTVIDAKDSKSFNCRIEYEKVDKATKNTLCNYDPSKTCYQEQTQSH
::::.:.:::... :.....:.::::::::::::.:.: :..:::.:::: :::::::::
NP_009 LVPPSKVVEFEVSPQSTLETKESKSFNCRIEYEKTDRAKKTALCNFDPSKICYQEQTQSH
160 170 180 190 200 210
230 240 250 260 270
pF1KE6 VSWLCSKPFKVICIYISFYSTDYKLVQKVCPDYNYHSDTPYFPSG
::::::::::::::::.:::.::::::::::::::::.:::. ::
NP_009 VSWLCSKPFKVICIYIAFYSVDYKLVQKVCPDYNYHSETPYLSSG
220 230 240 250 260
>>NP_009156 (OMIM: 604636) neurexophilin-3 precursor [Ho (252 aa)
initn: 906 init1: 838 opt: 847 Z-score: 1023.1 bits: 196.9 E(85289): 3e-50
Smith-Waterman score: 847; 65.1% identity (86.9% similar) in 175 aa overlap (97-271:79-252)
70 80 90 100 110 120
pF1KE6 ENDTDLDLRYDTPEPYSEQDLWDWLRNSTDLQEPRPRAKRRPIVKTGKFKKMFGWGDFHS
: .: : .. : ..: ::.::::::.:
NP_009 KRGHISPKSRPMANSTLLGLLAPPGEAWGILGQPPNRPNHSPP-PSAKVKKIFGWGDFYS
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE6 NIKTVKLNLLITGKIVDHGNGTFSVYFRHNSTGQGNVSVSLVPPTKIVEFDLAQQTVIDA
::::: ::::.::::::::::::::.:.::.:::::.:.:::::.: ::: :: :.:
NP_009 NIKTVALNLLVTGKIVDHGNGTFSVHFQHNATGQGNISISLVPPSKAVEFHQEQQIFIEA
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE6 KDSKSFNCRIEYEKVDKATKNTLCNYDPSKTCYQEQTQSHVSWLCSKPFKVICIYISFYS
: :: ::::.:.:::... ...::..::.: : ....:: ..: ::.::::.:.::.:::
NP_009 KASKIFNCRMEWEKVERGRRTSLCTHDPAKICSRDHAQSSATWSCSQPFKVVCVYIAFYS
170 180 190 200 210 220
250 260 270
pF1KE6 TDYKLVQKVCPDYNYHSDTPYFPSG
:::.:::::::::::::::::.:::
NP_009 TDYRLVQKVCPDYNYHSDTPYYPSG
230 240 250
>>NP_009155 (OMIM: 604637) neurexophilin-4 precursor [Ho (308 aa)
initn: 781 init1: 423 opt: 423 Z-score: 513.2 bits: 102.9 E(85289): 7.6e-22
Smith-Waterman score: 675; 44.4% identity (61.5% similar) in 257 aa overlap (79-268:51-307)
50 60 70 80 90
pF1KE6 SSKDLSISRLLSQTFRGKENDTDLDLRYDTPEPYSEQDL-------WDWLRNSTDLQE--
::: : . : : : : :
NP_009 VSAQIPESGRPQYLGLRPAAAGAGAPGQQLPEPRSSDGLGVGRAWSWAWPTNHTGALARA
30 40 50 60 70 80
100 110 120 130 140 150
pF1KE6 ------PRPRAKRRPIVKTGKFKKMFGWGDFHSNIKTVKLNLLITGKIVDHGNGTFSVYF
: :.::.: .:... ::.::::::. ..:.:..::.::::::: ::::::::
NP_009 GAAGALPAQRTKRKPSIKAARAKKIFGWGDFYFRVHTLKFSLLVTGKIVDHVNGTFSVYF
90 100 110 120 130 140
160 170 180
pF1KE6 RHNSTGQGNVSVSLVPPTKIVEFD---------------LAQQTVID-------------
::::.. ::.:::.:::.: ::: :: . :.
NP_009 RHNSSSLGNLSVSIVPPSKRVEFGGVWLPGPVPHPLQSTLALEGVLPGLGPPLGMAAAAA
150 160 170 180 190 200
190 200 210 220
pF1KE6 ------------------------AKDSKSFNCRIEYEKVDKATKNTLCNYDPSKTCYQE
::.:..:::..::::...: :. : ::::..:. :
NP_009 GPGLGGSLGGALAGPLGGALGVPGAKESRAFNCHVEYEKTNRARKHRPCLYDPSQVCFTE
210 220 230 240 250 260
230 240 250 260 270
pF1KE6 QTQSHVSWLCSKPFKVICIYISFYSTDYKLVQKVCPDYNYHSDTPYFPSG
.:::...:::.::::::::..:: : :::::::::::::..:. :::
NP_009 HTQSQAAWLCAKPFKVICIFVSFLSFDYKLVQKVCPDYNFQSEHPYFG
270 280 290 300
>>XP_016874236 (OMIM: 604637) PREDICTED: neurexophilin-4 (223 aa)
initn: 204 init1: 185 opt: 202 Z-score: 250.2 bits: 53.8 E(85289): 3.4e-07
Smith-Waterman score: 211; 35.7% identity (57.4% similar) in 115 aa overlap (79-174:51-165)
50 60 70 80 90
pF1KE6 SSKDLSISRLLSQTFRGKENDTDLDLRYDTPEPYSEQDL-------WDWLRNSTDLQE--
::: : . : : : : :
XP_016 VSAQIPESGRPQYLGLRPAAAGAGAPGQQLPEPRSSDGLGVGRAWSWAWPTNHTGALARA
30 40 50 60 70 80
100 110 120 130 140 150
pF1KE6 ------PRPRAKRRPIVKTGKFKKMFGWGDFHSNIKTVKLNLLITGKIVDHGNGTFSVYF
: :.::.: .:... ::.::::::. ..:.:..::.::::::: :. . .
XP_016 GAAGALPAQRTKRKPSIKAARAKKIFGWGDFYFRVHTLKFSLLVTGKIVDHVNALTTNWC
90 100 110 120 130 140
160 170 180 190 200
pF1KE6 RHNS-TGQGNVSVSL---VPPTKIVEFDLAQQTVIDAKDSKSFNCRIEYEKVDKATKNTL
:. . : . ::. .:: ..
XP_016 RRCAQTITSRVSTPTSDSAPPQPVLSLPPNPSLTRWDPLPSVLPLLWPCRPLLPLWGRRG
150 160 170 180 190 200
271 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 14:50:19 2016 done: Tue Nov 8 14:50:20 2016
Total Scan time: 4.850 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]