Result of FASTA (omim) for
pFN21AE6609
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6609, 299 aa
1>>>pF1KE6609 299 - 299 aa - 299 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9167+/-0.000424; mu= 17.3990+/- 0.026
mean_var=60.9217+/-13.084, 0's: 0 Z-trim(111.0): 30 B-trim: 1049 in 1/48
Lambda= 0.164319
statistics sampled from 19508 (19532) to 19508 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.591), E-opt: 0.2 (0.229), width: 16
Scan time: 4.480
The best scores are: opt bits E(85289)
NP_008849 (OMIM: 602286,607330) lathosterol oxidas ( 299) 2086 503.2 2.6e-142
NP_001020127 (OMIM: 602286,607330) lathosterol oxi ( 299) 2086 503.2 2.6e-142
NP_006736 (OMIM: 607545,616834) methylsterol monoo ( 293) 279 74.8 2.3e-13
XP_005263233 (OMIM: 607545,616834) PREDICTED: meth ( 293) 279 74.8 2.3e-13
NP_001017369 (OMIM: 607545,616834) methylsterol mo ( 162) 273 73.2 3.8e-13
NP_003947 (OMIM: 604551) cholesterol 25-hydroxylas ( 272) 206 57.4 3.5e-08
XP_006715794 (OMIM: 613738) PREDICTED: alkylglycer ( 423) 150 44.3 0.0005
XP_016867693 (OMIM: 613738) PREDICTED: alkylglycer ( 424) 150 44.3 0.0005
XP_011513704 (OMIM: 613738) PREDICTED: alkylglycer ( 437) 150 44.3 0.00051
NP_001004320 (OMIM: 613738) alkylglycerol monooxyg ( 445) 150 44.3 0.00052
XP_006715793 (OMIM: 613738) PREDICTED: alkylglycer ( 456) 150 44.3 0.00053
>>NP_008849 (OMIM: 602286,607330) lathosterol oxidase [H (299 aa)
initn: 2086 init1: 2086 opt: 2086 Z-score: 2675.9 bits: 503.2 E(85289): 2.6e-142
Smith-Waterman score: 2086; 100.0% identity (100.0% similar) in 299 aa overlap (1-299:1-299)
10 20 30 40 50 60
pF1KE6 MDLVLRVADYYFFTPYVYPATWPEDDIFRQAISLLIVTNVGAYILYFFCATLSYYFVFDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 MDLVLRVADYYFFTPYVYPATWPEDDIFRQAISLLIVTNVGAYILYFFCATLSYYFVFDH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ALMKHPQFLKNQVRREIKFTVQALPWISILTVALFLLEIRGYSKLHDDLGEFPYGLFELV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 ALMKHPQFLKNQVRREIKFTVQALPWISILTVALFLLEIRGYSKLHDDLGEFPYGLFELV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 VSIISFLFFTDMFIYWIHRGLHHRLVYKRLHKPHHIWKIPTPFASHAFHPIDGFLQSLPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 VSIISFLFFTDMFIYWIHRGLHHRLVYKRLHKPHHIWKIPTPFASHAFHPIDGFLQSLPY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 HIYPFIFPLHKVVYLSLYILVNIWTISIHDGDFRVPQILQPFINGSAHHTDHHMFFDYNY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 HIYPFIFPLHKVVYLSLYILVNIWTISIHDGDFRVPQILQPFINGSAHHTDHHMFFDYNY
190 200 210 220 230 240
250 260 270 280 290
pF1KE6 GQYFTLWDRIGGSFKNPSSFEGKGPLSYVKEMTEGKRSSHSGNGCKNEKLFNGEFTKTE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_008 GQYFTLWDRIGGSFKNPSSFEGKGPLSYVKEMTEGKRSSHSGNGCKNEKLFNGEFTKTE
250 260 270 280 290
>>NP_001020127 (OMIM: 602286,607330) lathosterol oxidase (299 aa)
initn: 2086 init1: 2086 opt: 2086 Z-score: 2675.9 bits: 503.2 E(85289): 2.6e-142
Smith-Waterman score: 2086; 100.0% identity (100.0% similar) in 299 aa overlap (1-299:1-299)
10 20 30 40 50 60
pF1KE6 MDLVLRVADYYFFTPYVYPATWPEDDIFRQAISLLIVTNVGAYILYFFCATLSYYFVFDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MDLVLRVADYYFFTPYVYPATWPEDDIFRQAISLLIVTNVGAYILYFFCATLSYYFVFDH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ALMKHPQFLKNQVRREIKFTVQALPWISILTVALFLLEIRGYSKLHDDLGEFPYGLFELV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALMKHPQFLKNQVRREIKFTVQALPWISILTVALFLLEIRGYSKLHDDLGEFPYGLFELV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 VSIISFLFFTDMFIYWIHRGLHHRLVYKRLHKPHHIWKIPTPFASHAFHPIDGFLQSLPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSIISFLFFTDMFIYWIHRGLHHRLVYKRLHKPHHIWKIPTPFASHAFHPIDGFLQSLPY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 HIYPFIFPLHKVVYLSLYILVNIWTISIHDGDFRVPQILQPFINGSAHHTDHHMFFDYNY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HIYPFIFPLHKVVYLSLYILVNIWTISIHDGDFRVPQILQPFINGSAHHTDHHMFFDYNY
190 200 210 220 230 240
250 260 270 280 290
pF1KE6 GQYFTLWDRIGGSFKNPSSFEGKGPLSYVKEMTEGKRSSHSGNGCKNEKLFNGEFTKTE
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GQYFTLWDRIGGSFKNPSSFEGKGPLSYVKEMTEGKRSSHSGNGCKNEKLFNGEFTKTE
250 260 270 280 290
>>NP_006736 (OMIM: 607545,616834) methylsterol monooxyge (293 aa)
initn: 268 init1: 152 opt: 279 Z-score: 360.9 bits: 74.8 E(85289): 2.3e-13
Smith-Waterman score: 279; 29.5% identity (55.1% similar) in 234 aa overlap (45-263:61-284)
20 30 40 50 60
pF1KE6 PYVYPATWPEDDIFRQAISLLIVTNVGAYILYF-FCATLSYYFVFDHALMKH------PQ
::: :: .. : : . :. :.
NP_006 EPFKNAWNYMLNNYTKFQIATWGSLIVHEALYFLFCLP-GFLFQFIPYMKKYKIQKDKPE
40 50 60 70 80
70 80 90 100 110 120
pF1KE6 FLKNQ-----VRREIKFTVQALPWISILTVALFLLEIRGYSKLHDDLGEFPYGLFELVVS
.:: : .: .: :: .. . .. : : .. : ..: : :..
NP_006 TWENQWKCFKVLLFNHFCIQ-LP---LICGTYYFTE---YFNIPYDWERMPRWYF-LLAR
90 100 110 120 130 140
130 140 150 160 170 180
pF1KE6 IISFLFFTDMFIYWIHRGLHHRLVYKRLHKPHHIWKIPTPFASHAFHPIDGFLQSLPYHI
.. . : . :..:: :::. .:: .:: :: .. : . .. ::.. .. . . :
NP_006 CFGCAVIEDTWHYFLHRLLHHKRIYKYIHKVHHEFQAPFGMEAEYAHPLETLILGTGFFI
150 160 170 180 190 200
190 200 210 220 230
pF1KE6 YPFIFPLHKVVYLSLYILVNIW-TISIHDG-DFRV-PQILQPFINGSAHHTDHHMFFDYN
.. : :. : .. . . ::..:.: :. . : : :: :: :: ::: : :
NP_006 GIVLLCDH-VILLWAWVTIRLLETIDVHSGYDIPLNPLNLIPFYAGSRHHDFHHMNFIGN
210 220 230 240 250 260
240 250 260 270 280 290
pF1KE6 YGQYFTLWDRIGGSFKNPSSFEGKGPLSYVKEMTEGKRSSHSGNGCKNEKLFNGEFTKTE
:.. :: :::: :. .. .... :
NP_006 YASTFTWWDRIFGTDSQYNAYNEKRKKFEKKTE
270 280 290
>>XP_005263233 (OMIM: 607545,616834) PREDICTED: methylst (293 aa)
initn: 268 init1: 152 opt: 279 Z-score: 360.9 bits: 74.8 E(85289): 2.3e-13
Smith-Waterman score: 279; 29.5% identity (55.1% similar) in 234 aa overlap (45-263:61-284)
20 30 40 50 60
pF1KE6 PYVYPATWPEDDIFRQAISLLIVTNVGAYILYF-FCATLSYYFVFDHALMKH------PQ
::: :: .. : : . :. :.
XP_005 EPFKNAWNYMLNNYTKFQIATWGSLIVHEALYFLFCLP-GFLFQFIPYMKKYKIQKDKPE
40 50 60 70 80
70 80 90 100 110 120
pF1KE6 FLKNQ-----VRREIKFTVQALPWISILTVALFLLEIRGYSKLHDDLGEFPYGLFELVVS
.:: : .: .: :: .. . .. : : .. : ..: : :..
XP_005 TWENQWKCFKVLLFNHFCIQ-LP---LICGTYYFTE---YFNIPYDWERMPRWYF-LLAR
90 100 110 120 130 140
130 140 150 160 170 180
pF1KE6 IISFLFFTDMFIYWIHRGLHHRLVYKRLHKPHHIWKIPTPFASHAFHPIDGFLQSLPYHI
.. . : . :..:: :::. .:: .:: :: .. : . .. ::.. .. . . :
XP_005 CFGCAVIEDTWHYFLHRLLHHKRIYKYIHKVHHEFQAPFGMEAEYAHPLETLILGTGFFI
150 160 170 180 190 200
190 200 210 220 230
pF1KE6 YPFIFPLHKVVYLSLYILVNIW-TISIHDG-DFRV-PQILQPFINGSAHHTDHHMFFDYN
.. : :. : .. . . ::..:.: :. . : : :: :: :: ::: : :
XP_005 GIVLLCDH-VILLWAWVTIRLLETIDVHSGYDIPLNPLNLIPFYAGSRHHDFHHMNFIGN
210 220 230 240 250 260
240 250 260 270 280 290
pF1KE6 YGQYFTLWDRIGGSFKNPSSFEGKGPLSYVKEMTEGKRSSHSGNGCKNEKLFNGEFTKTE
:.. :: :::: :. .. .... :
XP_005 YASTFTWWDRIFGTDSQYNAYNEKRKKFEKKTE
270 280 290
>>NP_001017369 (OMIM: 607545,616834) methylsterol monoox (162 aa)
initn: 268 init1: 152 opt: 273 Z-score: 356.9 bits: 73.2 E(85289): 3.8e-13
Smith-Waterman score: 273; 34.6% identity (62.5% similar) in 136 aa overlap (131-263:19-153)
110 120 130 140 150 160
pF1KE6 GYSKLHDDLGEFPYGLFELVVSIISFLFFTDMFIYWIHRGLHHRLVYKRLHKPHHIWKIP
: . :..:: :::. .:: .:: :: .. :
NP_001 MPRWYFLLARCFGCAVIEDTWHYFLHRLLHHKRIYKYIHKVHHEFQAP
10 20 30 40
170 180 190 200 210
pF1KE6 TPFASHAFHPIDGFLQSLPYHIYPFIFPLHKVVYLSLYILVNIW-TISIHDG-DFRV-PQ
. .. ::.. .. . . : .. : :. : .. . . ::..:.: :. . :
NP_001 FGMEAEYAHPLETLILGTGFFIGIVLLCDH-VILLWAWVTIRLLETIDVHSGYDIPLNPL
50 60 70 80 90 100
220 230 240 250 260 270
pF1KE6 ILQPFINGSAHHTDHHMFFDYNYGQYFTLWDRIGGSFKNPSSFEGKGPLSYVKEMTEGKR
: :: :: :: ::: : ::.. :: :::: :. .. .... :
NP_001 NLIPFYAGSRHHDFHHMNFIGNYASTFTWWDRIFGTDSQYNAYNEKRKKFEKKTE
110 120 130 140 150 160
280 290
pF1KE6 SSHSGNGCKNEKLFNGEFTKTE
>>NP_003947 (OMIM: 604551) cholesterol 25-hydroxylase [H (272 aa)
initn: 162 init1: 112 opt: 206 Z-score: 267.8 bits: 57.4 E(85289): 3.5e-08
Smith-Waterman score: 206; 30.3% identity (58.6% similar) in 152 aa overlap (116-258:121-268)
90 100 110 120 130 140
pF1KE6 WISILTVALFLLEIRGYSKLHDDLGEFPYGLFELVVSIISFLFFTDM-FIYWIHRGLHHR
:. :. :. :.. :: :. : : :::.
NP_003 TLYQHVMFVFPVTLLHWARSPALLPHEAPELLLLLHHILFCLLLFDMEFFVW-HL-LHHK
100 110 120 130 140
150 160 170 180 190 200
pF1KE6 L--VYKRLHKPHHIWKIPTPFASHAFHPIDGFLQSLPYHIYPFIFPLHKVVYLSLYILVN
. .:. .:: :: . .:.. . . : .. . .. : .. :.... ::
NP_003 VPWLYRTFHKVHHQNSSSFALATQYMSVWELFSLGFFDMMNVTLLGCHPLTTLTFHV-VN
150 160 170 180 190 200
210 220 230 240 250
pF1KE6 IW-TISIHDGDFRVP---QILQPF--INGSAHHTDHHMFFDYNYGQYFTLWDRIGGSFKN
:: .. :.: . : . : :: .: .:: :: :. :.. ::: ::.: :....
NP_003 IWLSVEDHSG-YNFPWSTHRLVPFGWYGGVVHHDLHHSHFNCNFAPYFTHWDKILGTLRT
210 220 230 240 250 260
260 270 280 290
pF1KE6 PSSFEGKGPLSYVKEMTEGKRSSHSGNGCKNEKLFNGEFTKTE
:
NP_003 ASVPAR
270
>>XP_006715794 (OMIM: 613738) PREDICTED: alkylglycerol m (423 aa)
initn: 182 init1: 81 opt: 150 Z-score: 193.3 bits: 44.3 E(85289): 0.0005
Smith-Waterman score: 150; 25.8% identity (54.5% similar) in 132 aa overlap (131-255:125-251)
110 120 130 140 150
pF1KE6 GYSKLHDDLGEFPYGLFELVVSIISFLFFTDMFIYWIHRGLHHRLVYKRLHKPHHI---W
:. ::.:: :. .. :. :: .
XP_006 TSYIYIWENYRLFNLPWDSPWTWYSAFLGVDFGYYWFHRMAHEVNIMWAGHQTHHSSEDY
100 110 120 130 140 150
160 170 180 190 200 210
pF1KE6 KIPTPFASHAFHPIDGFLQSLPYHIYPFIFPLHKVVYLSLYILVNIWTISIHDGDFRVPQ
.. : . . ... ... : . :: : .:.:.. .: ..: :: .
XP_006 NLSTALRQSVLQIYTSWIFYSPLAL--FIPPSVYAVHLQFNLLYQFW---IHTEVINNLG
160 170 180 190 200
220 230 240 250 260 270
pF1KE6 ILQPFINGSAHHTDHH----MFFDYNYGQYFTLWDRIGGSFKNPSSFEGKGPLSYVKEMT
:. ..: .:: :: . .: ::. . .::.: :.:.
XP_006 PLELILNTPSHHRVHHGRNRYCIDKNYAGVLIIWDKIFGTFEAENEKVVYGLTHPINTFE
210 220 230 240 250 260
280 290
pF1KE6 EGKRSSHSGNGCKNEKLFNGEFTKTE
XP_006 PIKVQFHHLFSIWTTFWATPGFFNKFSVIFKGPGWGPGKPRLGLSEEIPEVTGKEVPFSS
270 280 290 300 310 320
>>XP_016867693 (OMIM: 613738) PREDICTED: alkylglycerol m (424 aa)
initn: 182 init1: 81 opt: 150 Z-score: 193.3 bits: 44.3 E(85289): 0.0005
Smith-Waterman score: 150; 25.8% identity (54.5% similar) in 132 aa overlap (131-255:125-251)
110 120 130 140 150
pF1KE6 GYSKLHDDLGEFPYGLFELVVSIISFLFFTDMFIYWIHRGLHHRLVYKRLHKPHHI---W
:. ::.:: :. .. :. :: .
XP_016 TSYIYIWENYRLFNLPWDSPWTWYSAFLGVDFGYYWFHRMAHEVNIMWAGHQTHHSSEDY
100 110 120 130 140 150
160 170 180 190 200 210
pF1KE6 KIPTPFASHAFHPIDGFLQSLPYHIYPFIFPLHKVVYLSLYILVNIWTISIHDGDFRVPQ
.. : . . ... ... : . :: : .:.:.. .: ..: :: .
XP_016 NLSTALRQSVLQIYTSWIFYSPLAL--FIPPSVYAVHLQFNLLYQFW---IHTEVINNLG
160 170 180 190 200
220 230 240 250 260 270
pF1KE6 ILQPFINGSAHHTDHH----MFFDYNYGQYFTLWDRIGGSFKNPSSFEGKGPLSYVKEMT
:. ..: .:: :: . .: ::. . .::.: :.:.
XP_016 PLELILNTPSHHRVHHGRNRYCIDKNYAGVLIIWDKIFGTFEAENEKVVYGLTHPINTFE
210 220 230 240 250 260
280 290
pF1KE6 EGKRSSHSGNGCKNEKLFNGEFTKTE
XP_016 PIKVQFHHLFSIWTTFWATPGFFNKFSVIFKGPGWGPGKPRLGLSEEIPEVTGKEVPFSS
270 280 290 300 310 320
>>XP_011513704 (OMIM: 613738) PREDICTED: alkylglycerol m (437 aa)
initn: 182 init1: 81 opt: 150 Z-score: 193.1 bits: 44.3 E(85289): 0.00051
Smith-Waterman score: 150; 25.8% identity (54.5% similar) in 132 aa overlap (131-255:125-251)
110 120 130 140 150
pF1KE6 GYSKLHDDLGEFPYGLFELVVSIISFLFFTDMFIYWIHRGLHHRLVYKRLHKPHHI---W
:. ::.:: :. .. :. :: .
XP_011 TSYIYIWENYRLFNLPWDSPWTWYSAFLGVDFGYYWFHRMAHEVNIMWAGHQTHHSSEDY
100 110 120 130 140 150
160 170 180 190 200 210
pF1KE6 KIPTPFASHAFHPIDGFLQSLPYHIYPFIFPLHKVVYLSLYILVNIWTISIHDGDFRVPQ
.. : . . ... ... : . :: : .:.:.. .: ..: :: .
XP_011 NLSTALRQSVLQIYTSWIFYSPLAL--FIPPSVYAVHLQFNLLYQFW---IHTEVINNLG
160 170 180 190 200
220 230 240 250 260 270
pF1KE6 ILQPFINGSAHHTDHH----MFFDYNYGQYFTLWDRIGGSFKNPSSFEGKGPLSYVKEMT
:. ..: .:: :: . .: ::. . .::.: :.:.
XP_011 PLELILNTPSHHRVHHGRNRYCIDKNYAGVLIIWDKIFGTFEAENEKVVYGLTHPINTFE
210 220 230 240 250 260
280 290
pF1KE6 EGKRSSHSGNGCKNEKLFNGEFTKTE
XP_011 PIKVQFHHLFSIWTTFWATPGFFNKFSVIFKGPGWGPGKPRLGLSEEIPEVTGKEVPFSS
270 280 290 300 310 320
>>NP_001004320 (OMIM: 613738) alkylglycerol monooxygenas (445 aa)
initn: 162 init1: 81 opt: 150 Z-score: 193.0 bits: 44.3 E(85289): 0.00052
Smith-Waterman score: 150; 25.8% identity (54.5% similar) in 132 aa overlap (131-255:125-251)
110 120 130 140 150
pF1KE6 GYSKLHDDLGEFPYGLFELVVSIISFLFFTDMFIYWIHRGLHHRLVYKRLHKPHHI---W
:. ::.:: :. .. :. :: .
NP_001 TSYIYIWENYRLFNLPWDSPWTWYSAFLGVDFGYYWFHRMAHEVNIMWAGHQTHHSSEDY
100 110 120 130 140 150
160 170 180 190 200 210
pF1KE6 KIPTPFASHAFHPIDGFLQSLPYHIYPFIFPLHKVVYLSLYILVNIWTISIHDGDFRVPQ
.. : . . ... ... : . :: : .:.:.. .: ..: :: .
NP_001 NLSTALRQSVLQIYTSWIFYSPLAL--FIPPSVYAVHLQFNLLYQFW---IHTEVINNLG
160 170 180 190 200
220 230 240 250 260 270
pF1KE6 ILQPFINGSAHHTDHH----MFFDYNYGQYFTLWDRIGGSFKNPSSFEGKGPLSYVKEMT
:. ..: .:: :: . .: ::. . .::.: :.:.
NP_001 PLELILNTPSHHRVHHGRNRYCIDKNYAGVLIIWDKIFGTFEAENEKVVYGLTHPINTFE
210 220 230 240 250 260
280 290
pF1KE6 EGKRSSHSGNGCKNEKLFNGEFTKTE
NP_001 PIKVQFHHLFSIWTTFWATPGFFNKFSVIFKGPGWGPGKPRLGLSEEIPEVTGKEVPFSS
270 280 290 300 310 320
299 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 14:44:30 2016 done: Tue Nov 8 14:44:31 2016
Total Scan time: 4.480 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]