Result of FASTA (omim) for
pFN21AE6526
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6526, 150 aa
1>>>pF1KE6526 150 - 150 aa - 150 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2767+/-0.000277; mu= 12.3546+/- 0.017
mean_var=63.8862+/-12.957, 0's: 0 Z-trim(119.4): 16 B-trim: 1837 in 2/49
Lambda= 0.160461
statistics sampled from 33340 (33356) to 33340 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.772), E-opt: 0.2 (0.391), width: 16
Scan time: 3.560
The best scores are: opt bits E(85289)
NP_006299 (OMIM: 604624,613376) heat shock protein ( 150) 1001 239.4 1.7e-63
NP_001532 (OMIM: 602179) heat shock protein beta-2 ( 182) 240 63.3 2.1e-10
NP_001531 (OMIM: 602195,606595,608634) heat shock ( 205) 224 59.6 3e-09
NP_653218 (OMIM: 610695) heat shock protein beta-6 ( 160) 221 58.8 4e-09
NP_000385 (OMIM: 123580,604219) alpha-crystallin A ( 173) 216 57.7 9.5e-09
XP_005261150 (OMIM: 123580,604219) PREDICTED: alph ( 136) 212 56.7 1.5e-08
NP_001317308 (OMIM: 123590,608810,613763,613869,61 ( 108) 198 53.4 1.1e-07
XP_011540910 (OMIM: 123590,608810,613763,613869,61 ( 175) 200 54.0 1.2e-07
NP_001876 (OMIM: 123590,608810,613763,613869,61518 ( 175) 200 54.0 1.2e-07
NP_001276737 (OMIM: 123590,608810,613763,613869,61 ( 175) 200 54.0 1.2e-07
NP_001276736 (OMIM: 123590,608810,613763,613869,61 ( 175) 200 54.0 1.2e-07
NP_055180 (OMIM: 158590,608014,608673) heat shock ( 196) 173 47.8 1e-05
>>NP_006299 (OMIM: 604624,613376) heat shock protein bet (150 aa)
initn: 1001 init1: 1001 opt: 1001 Z-score: 1261.1 bits: 239.4 E(85289): 1.7e-63
Smith-Waterman score: 1001; 100.0% identity (100.0% similar) in 150 aa overlap (1-150:1-150)
10 20 30 40 50 60
pF1KE6 MAKIILRHLIEIPVRYQEEFEARGLEDCRLDHALYALPGPTIVDLRKTRAAQSPPVDSAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MAKIILRHLIEIPVRYQEEFEARGLEDCRLDHALYALPGPTIVDLRKTRAAQSPPVDSAA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ETPPREGKSHFQILLDVVQFLPEDIIIQTFEGWLLIKAQHGTRMDEHGFISRSFTRQYKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 ETPPREGKSHFQILLDVVQFLPEDIIIQTFEGWLLIKAQHGTRMDEHGFISRSFTRQYKL
70 80 90 100 110 120
130 140 150
pF1KE6 PDGVEIKDLSAVLCHDGILVVEVKDPVGTK
::::::::::::::::::::::::::::::
NP_006 PDGVEIKDLSAVLCHDGILVVEVKDPVGTK
130 140 150
>>NP_001532 (OMIM: 602179) heat shock protein beta-2 [Ho (182 aa)
initn: 257 init1: 236 opt: 240 Z-score: 307.8 bits: 63.3 E(85289): 2.1e-10
Smith-Waterman score: 240; 37.5% identity (66.3% similar) in 104 aa overlap (47-150:50-151)
20 30 40 50 60 70
pF1KE6 QEEFEARGLEDCRLDHALYALPGPTIVDLRKTRAAQSPPVDSAAETPPREGKSHFQILLD
. ::: . . :. . : ....:: .::
NP_001 NPSRLGEQRFGEGLLPEEILTPTLYHGYYVRPRAAPAGEGSRAGASELRLSEGKFQAFLD
20 30 40 50 60 70
80 90 100 110 120 130
pF1KE6 VVQFLPEDIIIQTFEGWLLIKAQHGTRMDEHGFISRSFTRQYKLPDGVEIKDLSAVLCHD
: .: :... ..: .. : ..:.: :.:.:::.:: : : : :: :. . :.: ::
NP_001 VSHFTPDEVTVRTVDNLLEVSARHPQRLDRHGFVSREFCRTYVLPADVDPWRVRAALSHD
80 90 100 110 120 130
140 150
pF1KE6 GILVVEVKDPVGTK
::: .:. : : .
NP_001 GILNLEA--PRGGRHLDTEVNEVYISLLPAPPDPEEEEEAAIVEP
140 150 160 170 180
>>NP_001531 (OMIM: 602195,606595,608634) heat shock prot (205 aa)
initn: 213 init1: 213 opt: 224 Z-score: 287.0 bits: 59.6 E(85289): 3e-09
Smith-Waterman score: 224; 34.2% identity (67.6% similar) in 111 aa overlap (36-146:62-170)
10 20 30 40 50 60
pF1KE6 LRHLIEIPVRYQEEFEARGLEDCRLDHALYALPGPTIVDLRKTRAAQSPPVDSAAETPPR
:. .:... .:: . ....: :
NP_001 AFGLPRLPEEWSQWLGGSSWPGYVRPLPPAAIESPAVAAPAYSRALSRQLSSGVSEI--R
40 50 60 70 80
70 80 90 100 110 120
pF1KE6 EGKSHFQILLDVVQFLPEDIIIQTFEGWLLIKAQHGTRMDEHGFISRSFTRQYKLPDGVE
. ..... ::: .: :... ..: .: . : ..: :.::::.::: :::.: :: ::.
NP_001 HTADRWRVSLDVNHFAPDELTVKTKDGVVEITGKHEERQDEHGYISRCFTRKYTLPPGVD
90 100 110 120 130 140
130 140 150
pF1KE6 IKDLSAVLCHDGILVVEVKDPVGTK
..:. : .: :.::. :
NP_001 PTQVSSSLSPEGTLTVEAPMPKLATQSNEITIPVTFESRAQLGGPEAAKSDETAAK
150 160 170 180 190 200
>>NP_653218 (OMIM: 610695) heat shock protein beta-6 [Ho (160 aa)
initn: 204 init1: 189 opt: 221 Z-score: 284.9 bits: 58.8 E(85289): 4e-09
Smith-Waterman score: 222; 35.1% identity (60.3% similar) in 131 aa overlap (13-142:25-145)
10 20 30 40
pF1KE6 MAKIILRHLIEIPVRYQEEFEARGLEDCRLDHALYALPGPTIVDLRKT
: : .. ..:: :. : :: :: .
NP_653 MEIPVPVQPSWLRRASAPLPGLSAPGRLFDQRFGEGL----LEAELAAL-CPTTLAPYYL
10 20 30 40 50
50 60 70 80 90 100
pF1KE6 RAAQSP-PVDSAAETPPREGKSHFQILLDVVQFLPEDIIIQTFEGWLLIKAQHGTRMDEH
:: . :: :..: : ::..:::: .: ::.: ... . ..:.: : :::
NP_653 RAPSVALPV---AQVPTDPG--HFSVLLDVKHFSPEEIAVKVVGEHVEVHARHEERPDEH
60 70 80 90 100 110
110 120 130 140 150
pF1KE6 GFISRSFTRQYKLPDGVEIKDLSAVLCHDGILVVEVKDPVGTK
::..: : :.:.:: ::. ....: .:.: ..
NP_653 GFVAREFHRRYRLPPGVDPAAVTSALSPEGVLSIQAAPASAQAPPPAAAK
120 130 140 150 160
>>NP_000385 (OMIM: 123580,604219) alpha-crystallin A cha (173 aa)
initn: 193 init1: 193 opt: 216 Z-score: 278.1 bits: 57.7 E(85289): 9.5e-09
Smith-Waterman score: 216; 32.3% identity (64.6% similar) in 127 aa overlap (13-139:19-139)
10 20 30 40 50
pF1KE6 MAKIILRHLIEIPVRYQEEFEARGLEDCRLDHALYALPGPTIVDLRKTRAAQSP
: : ..: ..:: ... : . . :: . ..
NP_000 MDVTIQHPWFKRTLGPFYPSRLFDQFFGEGL----FEYDLLPFLSSTISPYYRQSLFRTV
10 20 30 40 50
60 70 80 90 100 110
pF1KE6 PVDSAAETPPREGKSHFQILLDVVQFLPEDIIIQTFEGWLLIKAQHGTRMDEHGFISRSF
.::. . : ...: :.::: .: :::. ... . .. :...:. :.:.::.::: :
NP_000 -LDSGI-SEVRSDRDKFVIFLDVKHFSPEDLTVKVQDDFVEIHGKHNERQDDHGYISREF
60 70 80 90 100 110
120 130 140 150
pF1KE6 TRQYKLPDGVEIKDLSAVLCHDGILVVEVKDPVGTK
:.:.::..:. . :: : ::.:
NP_000 HRRYRLPSNVDQSALSCSLSADGMLTFCGPKIQTGLDATHAERAIPVSREEKPTSAPSS
120 130 140 150 160 170
>>XP_005261150 (OMIM: 123580,604219) PREDICTED: alpha-cr (136 aa)
initn: 193 init1: 193 opt: 212 Z-score: 274.7 bits: 56.7 E(85289): 1.5e-08
Smith-Waterman score: 212; 41.3% identity (76.0% similar) in 75 aa overlap (65-139:28-102)
40 50 60 70 80 90
pF1KE6 YALPGPTIVDLRKTRAAQSPPVDSAAETPPREGKSHFQILLDVVQFLPEDIIIQTFEGWL
: ...: :.::: .: :::. ... . ..
XP_005 MPVCPGDSHRPPKALPHLVCGRRGRQVRSDRDKFVIFLDVKHFSPEDLTVKVQDDFV
10 20 30 40 50
100 110 120 130 140 150
pF1KE6 LIKAQHGTRMDEHGFISRSFTRQYKLPDGVEIKDLSAVLCHDGILVVEVKDPVGTK
:...:. :.:.::.::: : :.:.::..:. . :: : ::.:
XP_005 EIHGKHNERQDDHGYISREFHRRYRLPSNVDQSALSCSLSADGMLTFCGPKIQTGLDATH
60 70 80 90 100 110
XP_005 AERAIPVSREEKPTSAPSS
120 130
>>NP_001317308 (OMIM: 123590,608810,613763,613869,615184 (108 aa)
initn: 194 init1: 183 opt: 198 Z-score: 258.7 bits: 53.4 E(85289): 1.1e-07
Smith-Waterman score: 198; 37.7% identity (71.4% similar) in 77 aa overlap (65-141:2-78)
40 50 60 70 80 90
pF1KE6 YALPGPTIVDLRKTRAAQSPPVDSAAETPPREGKSHFQILLDVVQFLPEDIIIQTFEGWL
: :..:.. ::: .: ::.. .... .
NP_001 MRLEKDRFSVNLDVKHFSPEELKVKVLGDVI
10 20 30
100 110 120 130 140 150
pF1KE6 LIKAQHGTRMDEHGFISRSFTRQYKLPDGVEIKDLSAVLCHDGILVVEVKDPVGTK
....: :.:::::::: : :.:..: :. ... : ::.:.:
NP_001 EVHGKHEERQDEHGFISREFHRKYRIPADVDPLTITSSLSSDGVLTVNGPRKQVSGPERT
40 50 60 70 80 90
NP_001 IPITREEKPAVTAAPKK
100
>>XP_011540910 (OMIM: 123590,608810,613763,613869,615184 (175 aa)
initn: 196 init1: 183 opt: 200 Z-score: 258.0 bits: 54.0 E(85289): 1.2e-07
Smith-Waterman score: 200; 33.0% identity (66.0% similar) in 97 aa overlap (45-141:49-145)
20 30 40 50 60 70
pF1KE6 RYQEEFEARGLEDCRLDHALYALPGPTIVDLRKTRAAQSPPVDSAAETPPREGKSHFQIL
:: ..: ... . : :..:..
XP_011 SPSRLFDQFFGEHLLESDLFPTSTSLSPFYLRPPSFLRAPSWFDTGLSEMRLEKDRFSVN
20 30 40 50 60 70
80 90 100 110 120 130
pF1KE6 LDVVQFLPEDIIIQTFEGWLLIKAQHGTRMDEHGFISRSFTRQYKLPDGVEIKDLSAVLC
::: .: ::.. .... . ....: :.:::::::: : :.:..: :. ... :
XP_011 LDVKHFSPEELKVKVLGDVIEVHGKHEERQDEHGFISREFHRKYRIPADVDPLTITSSLS
80 90 100 110 120 130
140 150
pF1KE6 HDGILVVEVKDPVGTK
::.:.:
XP_011 SDGVLTVNGPRKQVSGPERTIPITREEKPAVTAAPKK
140 150 160 170
>>NP_001876 (OMIM: 123590,608810,613763,613869,615184) a (175 aa)
initn: 196 init1: 183 opt: 200 Z-score: 258.0 bits: 54.0 E(85289): 1.2e-07
Smith-Waterman score: 200; 33.0% identity (66.0% similar) in 97 aa overlap (45-141:49-145)
20 30 40 50 60 70
pF1KE6 RYQEEFEARGLEDCRLDHALYALPGPTIVDLRKTRAAQSPPVDSAAETPPREGKSHFQIL
:: ..: ... . : :..:..
NP_001 SPSRLFDQFFGEHLLESDLFPTSTSLSPFYLRPPSFLRAPSWFDTGLSEMRLEKDRFSVN
20 30 40 50 60 70
80 90 100 110 120 130
pF1KE6 LDVVQFLPEDIIIQTFEGWLLIKAQHGTRMDEHGFISRSFTRQYKLPDGVEIKDLSAVLC
::: .: ::.. .... . ....: :.:::::::: : :.:..: :. ... :
NP_001 LDVKHFSPEELKVKVLGDVIEVHGKHEERQDEHGFISREFHRKYRIPADVDPLTITSSLS
80 90 100 110 120 130
140 150
pF1KE6 HDGILVVEVKDPVGTK
::.:.:
NP_001 SDGVLTVNGPRKQVSGPERTIPITREEKPAVTAAPKK
140 150 160 170
>>NP_001276737 (OMIM: 123590,608810,613763,613869,615184 (175 aa)
initn: 196 init1: 183 opt: 200 Z-score: 258.0 bits: 54.0 E(85289): 1.2e-07
Smith-Waterman score: 200; 33.0% identity (66.0% similar) in 97 aa overlap (45-141:49-145)
20 30 40 50 60 70
pF1KE6 RYQEEFEARGLEDCRLDHALYALPGPTIVDLRKTRAAQSPPVDSAAETPPREGKSHFQIL
:: ..: ... . : :..:..
NP_001 SPSRLFDQFFGEHLLESDLFPTSTSLSPFYLRPPSFLRAPSWFDTGLSEMRLEKDRFSVN
20 30 40 50 60 70
80 90 100 110 120 130
pF1KE6 LDVVQFLPEDIIIQTFEGWLLIKAQHGTRMDEHGFISRSFTRQYKLPDGVEIKDLSAVLC
::: .: ::.. .... . ....: :.:::::::: : :.:..: :. ... :
NP_001 LDVKHFSPEELKVKVLGDVIEVHGKHEERQDEHGFISREFHRKYRIPADVDPLTITSSLS
80 90 100 110 120 130
140 150
pF1KE6 HDGILVVEVKDPVGTK
::.:.:
NP_001 SDGVLTVNGPRKQVSGPERTIPITREEKPAVTAAPKK
140 150 160 170
150 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 14:06:37 2016 done: Tue Nov 8 14:06:38 2016
Total Scan time: 3.560 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]