Result of FASTA (omim) for
pFN21AE6514
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6514, 147 aa
1>>>pF1KE6514 147 - 147 aa - 147 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2201+/-0.000313; mu= 11.6598+/- 0.020
mean_var=57.6141+/-11.345, 0's: 0 Z-trim(114.9): 32 B-trim: 37 in 1/51
Lambda= 0.168970
statistics sampled from 25006 (25038) to 25006 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.693), E-opt: 0.2 (0.294), width: 16
Scan time: 3.250
The best scores are: opt bits E(85289)
NP_640342 (OMIM: 608402) membrane-spanning 4-domai ( 147) 928 234.0 6.5e-62
XP_016873614 (OMIM: 606548) PREDICTED: membrane-sp ( 145) 293 79.2 2.6e-15
XP_011543511 (OMIM: 606548) PREDICTED: membrane-sp ( 148) 293 79.2 2.6e-15
NP_690590 (OMIM: 606548) membrane-spanning 4-domai ( 178) 293 79.3 3.1e-15
NP_071744 (OMIM: 606548) membrane-spanning 4-domai ( 225) 293 79.3 3.8e-15
NP_690591 (OMIM: 606548) membrane-spanning 4-domai ( 248) 293 79.3 4.1e-15
NP_001234928 (OMIM: 606548) membrane-spanning 4-do ( 253) 293 79.3 4.2e-15
NP_001317204 (OMIM: 606548) membrane-spanning 4-do ( 276) 293 79.3 4.5e-15
XP_005274234 (OMIM: 606548) PREDICTED: membrane-sp ( 276) 293 79.3 4.5e-15
XP_016873613 (OMIM: 606548) PREDICTED: membrane-sp ( 180) 283 76.8 1.7e-14
XP_016873612 (OMIM: 606548) PREDICTED: membrane-sp ( 203) 283 76.9 1.9e-14
XP_006718724 (OMIM: 606548) PREDICTED: membrane-sp ( 208) 283 76.9 1.9e-14
XP_006718723 (OMIM: 606548) PREDICTED: membrane-sp ( 231) 283 76.9 2.1e-14
NP_996823 (OMIM: 606502) membrane-spanning 4-domai ( 195) 182 52.2 4.7e-07
NP_996821 (OMIM: 606502) membrane-spanning 4-domai ( 195) 182 52.2 4.7e-07
NP_996822 (OMIM: 606502) membrane-spanning 4-domai ( 240) 182 52.3 5.6e-07
NP_067024 (OMIM: 606502) membrane-spanning 4-domai ( 240) 182 52.3 5.6e-07
>>NP_640342 (OMIM: 608402) membrane-spanning 4-domains s (147 aa)
initn: 928 init1: 928 opt: 928 Z-score: 1232.5 bits: 234.0 E(85289): 6.5e-62
Smith-Waterman score: 928; 100.0% identity (100.0% similar) in 147 aa overlap (1-147:1-147)
10 20 30 40 50 60
pF1KE6 MTSQPISNETIIMLPSNVINFSQAEKPEPTNQGQDSLKKRLQAKVKVIGVHSSLAGSILS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_640 MTSQPISNETIIMLPSNVINFSQAEKPEPTNQGQDSLKKRLQAKVKVIGVHSSLAGSILS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ALSALVGFILLSVNPAALNPASLQCKLDEKDIPTRLLLSYDYHSPYTMDCHRAKASLAGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_640 ALSALVGFILLSVNPAALNPASLQCKLDEKDIPTRLLLSYDYHSPYTMDCHRAKASLAGT
70 80 90 100 110 120
130 140
pF1KE6 LSLMLVSTVLEFCLAVLTAVLQWKQTV
:::::::::::::::::::::::::::
NP_640 LSLMLVSTVLEFCLAVLTAVLQWKQTV
130 140
>>XP_016873614 (OMIM: 606548) PREDICTED: membrane-spanni (145 aa)
initn: 295 init1: 277 opt: 293 Z-score: 396.0 bits: 79.2 E(85289): 2.6e-15
Smith-Waterman score: 293; 61.9% identity (79.8% similar) in 84 aa overlap (1-84:29-105)
10 20 30
pF1KE6 MTSQPISNETIIMLPSNVINFSQAEKPEPTNQ
:::::. :::::.:::::::::::::::::::
XP_016 MVLLKLLEVYRKGSAGTFHKSTIFGNTIMTSQPVPNETIIVLPSNVINFSQAEKPEPTNQ
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE6 GQDSLKKRLQAKVKVIGVHSSLAGSILSALSALVGFILLSVNPAALNPASLQCKLDEKDI
:::::::.:.:..::::. . : : .. .: :.:: : :...: :
XP_016 GQDSLKKHLHAEIKVIGTIQILCGMMVLSL----GIILAS---ASFSPNFTQVTSTLLNS
70 80 90 100 110
100 110 120 130 140
pF1KE6 PTRLLLSYDYHSPYTMDCHRAKASLAGTLSLMLVSTVLEFCLAVLTAVLQWKQTV
XP_016 AYPFIGPFFFIISGSLSIATEKRLTKLLGFLS
120 130 140
>>XP_011543511 (OMIM: 606548) PREDICTED: membrane-spanni (148 aa)
initn: 277 init1: 277 opt: 293 Z-score: 395.8 bits: 79.2 E(85289): 2.6e-15
Smith-Waterman score: 293; 61.9% identity (79.8% similar) in 84 aa overlap (1-84:29-105)
10 20 30
pF1KE6 MTSQPISNETIIMLPSNVINFSQAEKPEPTNQ
:::::. :::::.:::::::::::::::::::
XP_011 MVLLKLLEVYRKGSAGTFHKSTIFGNTIMTSQPVPNETIIVLPSNVINFSQAEKPEPTNQ
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE6 GQDSLKKRLQAKVKVIGVHSSLAGSILSALSALVGFILLSVNPAALNPASLQCKLDEKDI
:::::::.:.:..::::. . : : .. .: :.:: : :...: :
XP_011 GQDSLKKHLHAEIKVIGTIQILCGMMVLSL----GIILAS---ASFSPNFTQVTSTLLNS
70 80 90 100 110
100 110 120 130 140
pF1KE6 PTRLLLSYDYHSPYTMDCHRAKASLAGTLSLMLVSTVLEFCLAVLTAVLQWKQTV
XP_011 AYPFIGPFFFIISGSLSIATEKRLTKLLGLMLEIM
120 130 140
>>NP_690590 (OMIM: 606548) membrane-spanning 4-domains s (178 aa)
initn: 316 init1: 277 opt: 293 Z-score: 394.6 bits: 79.3 E(85289): 3.1e-15
Smith-Waterman score: 317; 45.2% identity (54.8% similar) in 168 aa overlap (1-103:1-168)
10 20 30 40
pF1KE6 MTSQPISNETIIMLPSNVINFSQAEKPEPTNQGQDSLKKRLQAKVKVIG-----------
:::::. :::::.::::::::::::::::::::::::::.:.:..::::
NP_690 MTSQPVPNETIIVLPSNVINFSQAEKPEPTNQGQDSLKKHLHAEIKVIGTIQILCGMMVL
10 20 30 40 50 60
50
pF1KE6 -----------------------------------------------------VHSSLAG
:::::.:
NP_690 SLGIILASASFSPNFTQVTSTLLNSAYPFIGPFFFIISGSLSIATEKRLTKLLVHSSLVG
70 80 90 100 110 120
60 70 80 90 100 110
pF1KE6 SILSALSALVGFILLSVNPAALNPASLQ-CKLDEKDIPTRLLLSYDYHSPYTMDCHRAKA
:::::::::::::.:::. :.::::::: .:.. :. . .: :
NP_690 SILSALSALVGFIILSVKQATLNPASLQWNSLSDADLHSAGILPSCAHCCAAVETGLL
130 140 150 160 170
120 130 140
pF1KE6 SLAGTLSLMLVSTVLEFCLAVLTAVLQWKQTV
>>NP_071744 (OMIM: 606548) membrane-spanning 4-domains s (225 aa)
initn: 512 init1: 277 opt: 293 Z-score: 393.0 bits: 79.3 E(85289): 3.8e-15
Smith-Waterman score: 427; 50.3% identity (59.2% similar) in 179 aa overlap (1-114:1-179)
10 20 30 40
pF1KE6 MTSQPISNETIIMLPSNVINFSQAEKPEPTNQGQDSLKKRLQAKVKVIG-----------
:::::. :::::.::::::::::::::::::::::::::.:.:..::::
NP_071 MTSQPVPNETIIVLPSNVINFSQAEKPEPTNQGQDSLKKHLHAEIKVIGTIQILCGMMVL
10 20 30 40 50 60
50
pF1KE6 -----------------------------------------------------VHSSLAG
:::::.:
NP_071 SLGIILASASFSPNFTQVTSTLLNSAYPFIGPFFFIISGSLSIATEKRLTKLLVHSSLVG
70 80 90 100 110 120
60 70 80 90 100 110
pF1KE6 SILSALSALVGFILLSVNPAALNPASLQCKLDEKDIPTRLLLSYDYH-SPYTMDCHRAKA
:::::::::::::.:::. :.::::::::.::...:::: .:: :: : :: ::. ::
NP_071 SILSALSALVGFIILSVKQATLNPASLQCELDKNNIPTRSYVSYFYHDSLYTTDCYTAKA
130 140 150 160 170 180
120 130 140
pF1KE6 SLAGTLSLMLVSTVLEFCLAVLTAVLQWKQTV
NP_071 SLAGTLSLMLICTLLEFCLAVLTAVLRWKQAYSDFPGVSVLAGFT
190 200 210 220
>--
initn: 170 init1: 170 opt: 170 Z-score: 230.9 bits: 49.3 E(85289): 4e-06
Smith-Waterman score: 170; 87.1% identity (96.8% similar) in 31 aa overlap (115-145:180-210)
90 100 110 120 130 140
pF1KE6 CKLDEKDIPTRLLLSYDYHSPYTMDCHRAKASLAGTLSLMLVSTVLEFCLAVLTAVLQWK
:::::::::::. :.::::::::::::.::
NP_071 ELDKNNIPTRSYVSYFYHDSLYTTDCYTAKASLAGTLSLMLICTLLEFCLAVLTAVLRWK
150 160 170 180 190 200
pF1KE6 QTV
:
NP_071 QAYSDFPGVSVLAGFT
210 220
>>NP_690591 (OMIM: 606548) membrane-spanning 4-domains s (248 aa)
initn: 512 init1: 277 opt: 293 Z-score: 392.3 bits: 79.3 E(85289): 4.1e-15
Smith-Waterman score: 427; 50.3% identity (59.2% similar) in 179 aa overlap (1-114:1-179)
10 20 30 40
pF1KE6 MTSQPISNETIIMLPSNVINFSQAEKPEPTNQGQDSLKKRLQAKVKVIG-----------
:::::. :::::.::::::::::::::::::::::::::.:.:..::::
NP_690 MTSQPVPNETIIVLPSNVINFSQAEKPEPTNQGQDSLKKHLHAEIKVIGTIQILCGMMVL
10 20 30 40 50 60
50
pF1KE6 -----------------------------------------------------VHSSLAG
:::::.:
NP_690 SLGIILASASFSPNFTQVTSTLLNSAYPFIGPFFFIISGSLSIATEKRLTKLLVHSSLVG
70 80 90 100 110 120
60 70 80 90 100 110
pF1KE6 SILSALSALVGFILLSVNPAALNPASLQCKLDEKDIPTRLLLSYDYH-SPYTMDCHRAKA
:::::::::::::.:::. :.::::::::.::...:::: .:: :: : :: ::. ::
NP_690 SILSALSALVGFIILSVKQATLNPASLQCELDKNNIPTRSYVSYFYHDSLYTTDCYTAKA
130 140 150 160 170 180
120 130 140
pF1KE6 SLAGTLSLMLVSTVLEFCLAVLTAVLQWKQTV
NP_690 SLAGTLSLMLICTLLEFCLAVLTAVLRWKQAYSDFPGSVLFLPHSYIGNSGMSSKMTHDC
190 200 210 220 230 240
>--
initn: 170 init1: 170 opt: 170 Z-score: 230.2 bits: 49.3 E(85289): 4.4e-06
Smith-Waterman score: 170; 87.1% identity (96.8% similar) in 31 aa overlap (115-145:180-210)
90 100 110 120 130 140
pF1KE6 CKLDEKDIPTRLLLSYDYHSPYTMDCHRAKASLAGTLSLMLVSTVLEFCLAVLTAVLQWK
:::::::::::. :.::::::::::::.::
NP_690 ELDKNNIPTRSYVSYFYHDSLYTTDCYTAKASLAGTLSLMLICTLLEFCLAVLTAVLRWK
150 160 170 180 190 200
pF1KE6 QTV
:
NP_690 QAYSDFPGSVLFLPHSYIGNSGMSSKMTHDCGYEELLTS
210 220 230 240
>>NP_001234928 (OMIM: 606548) membrane-spanning 4-domain (253 aa)
initn: 512 init1: 277 opt: 293 Z-score: 392.2 bits: 79.3 E(85289): 4.2e-15
Smith-Waterman score: 427; 50.3% identity (59.2% similar) in 179 aa overlap (1-114:29-207)
10 20 30
pF1KE6 MTSQPISNETIIMLPSNVINFSQAEKPEPTNQ
:::::. :::::.:::::::::::::::::::
NP_001 MVLLKLLEVYRKGSAGTFHKSTIFGNTIMTSQPVPNETIIVLPSNVINFSQAEKPEPTNQ
10 20 30 40 50 60
40
pF1KE6 GQDSLKKRLQAKVKVIG-------------------------------------------
:::::::.:.:..::::
NP_001 GQDSLKKHLHAEIKVIGTIQILCGMMVLSLGIILASASFSPNFTQVTSTLLNSAYPFIGP
70 80 90 100 110 120
50 60 70 80
pF1KE6 ---------------------VHSSLAGSILSALSALVGFILLSVNPAALNPASLQCKLD
:::::.::::::::::::::.:::. :.::::::::.::
NP_001 FFFIISGSLSIATEKRLTKLLVHSSLVGSILSALSALVGFIILSVKQATLNPASLQCELD
130 140 150 160 170 180
90 100 110 120 130 140
pF1KE6 EKDIPTRLLLSYDYH-SPYTMDCHRAKASLAGTLSLMLVSTVLEFCLAVLTAVLQWKQTV
...:::: .:: :: : :: ::. ::
NP_001 KNNIPTRSYVSYFYHDSLYTTDCYTAKASLAGTLSLMLICTLLEFCLAVLTAVLRWKQAY
190 200 210 220 230 240
>--
initn: 170 init1: 170 opt: 170 Z-score: 230.1 bits: 49.3 E(85289): 4.4e-06
Smith-Waterman score: 170; 87.1% identity (96.8% similar) in 31 aa overlap (115-145:208-238)
90 100 110 120 130 140
pF1KE6 CKLDEKDIPTRLLLSYDYHSPYTMDCHRAKASLAGTLSLMLVSTVLEFCLAVLTAVLQWK
:::::::::::. :.::::::::::::.::
NP_001 ELDKNNIPTRSYVSYFYHDSLYTTDCYTAKASLAGTLSLMLICTLLEFCLAVLTAVLRWK
180 190 200 210 220 230
pF1KE6 QTV
:
NP_001 QAYSDFPGVSVLAGFT
240 250
>>NP_001317204 (OMIM: 606548) membrane-spanning 4-domain (276 aa)
initn: 498 init1: 277 opt: 293 Z-score: 391.6 bits: 79.3 E(85289): 4.5e-15
Smith-Waterman score: 427; 50.3% identity (59.2% similar) in 179 aa overlap (1-114:29-207)
10 20 30
pF1KE6 MTSQPISNETIIMLPSNVINFSQAEKPEPTNQ
:::::. :::::.:::::::::::::::::::
NP_001 MVLLKLLEVYRKGSAGTFHKSTIFGNTIMTSQPVPNETIIVLPSNVINFSQAEKPEPTNQ
10 20 30 40 50 60
40
pF1KE6 GQDSLKKRLQAKVKVIG-------------------------------------------
:::::::.:.:..::::
NP_001 GQDSLKKHLHAEIKVIGTIQILCGMMVLSLGIILASASFSPNFTQVTSTLLNSAYPFIGP
70 80 90 100 110 120
50 60 70 80
pF1KE6 ---------------------VHSSLAGSILSALSALVGFILLSVNPAALNPASLQCKLD
:::::.::::::::::::::.:::. :.::::::::.::
NP_001 FFFIISGSLSIATEKRLTKLLVHSSLVGSILSALSALVGFIILSVKQATLNPASLQCELD
130 140 150 160 170 180
90 100 110 120 130 140
pF1KE6 EKDIPTRLLLSYDYH-SPYTMDCHRAKASLAGTLSLMLVSTVLEFCLAVLTAVLQWKQTV
...:::: .:: :: : :: ::. ::
NP_001 KNNIPTRSYVSYFYHDSLYTTDCYTAKASLAGTLSLMLICTLLEFCLAVLTAVLRWKQAY
190 200 210 220 230 240
>--
initn: 170 init1: 170 opt: 170 Z-score: 229.5 bits: 49.4 E(85289): 4.8e-06
Smith-Waterman score: 170; 87.1% identity (96.8% similar) in 31 aa overlap (115-145:208-238)
90 100 110 120 130 140
pF1KE6 CKLDEKDIPTRLLLSYDYHSPYTMDCHRAKASLAGTLSLMLVSTVLEFCLAVLTAVLQWK
:::::::::::. :.::::::::::::.::
NP_001 ELDKNNIPTRSYVSYFYHDSLYTTDCYTAKASLAGTLSLMLICTLLEFCLAVLTAVLRWK
180 190 200 210 220 230
pF1KE6 QTV
:
NP_001 QAYSDFPGSVLFLPHSYIGNSGMSSKMTHDCGYEELLTS
240 250 260 270
>>XP_005274234 (OMIM: 606548) PREDICTED: membrane-spanni (276 aa)
initn: 498 init1: 277 opt: 293 Z-score: 391.6 bits: 79.3 E(85289): 4.5e-15
Smith-Waterman score: 427; 50.3% identity (59.2% similar) in 179 aa overlap (1-114:29-207)
10 20 30
pF1KE6 MTSQPISNETIIMLPSNVINFSQAEKPEPTNQ
:::::. :::::.:::::::::::::::::::
XP_005 MVLLKLLEVYRKGSAGTFHKSTIFGNTIMTSQPVPNETIIVLPSNVINFSQAEKPEPTNQ
10 20 30 40 50 60
40
pF1KE6 GQDSLKKRLQAKVKVIG-------------------------------------------
:::::::.:.:..::::
XP_005 GQDSLKKHLHAEIKVIGTIQILCGMMVLSLGIILASASFSPNFTQVTSTLLNSAYPFIGP
70 80 90 100 110 120
50 60 70 80
pF1KE6 ---------------------VHSSLAGSILSALSALVGFILLSVNPAALNPASLQCKLD
:::::.::::::::::::::.:::. :.::::::::.::
XP_005 FFFIISGSLSIATEKRLTKLLVHSSLVGSILSALSALVGFIILSVKQATLNPASLQCELD
130 140 150 160 170 180
90 100 110 120 130 140
pF1KE6 EKDIPTRLLLSYDYH-SPYTMDCHRAKASLAGTLSLMLVSTVLEFCLAVLTAVLQWKQTV
...:::: .:: :: : :: ::. ::
XP_005 KNNIPTRSYVSYFYHDSLYTTDCYTAKASLAGTLSLMLICTLLEFCLAVLTAVLRWKQAY
190 200 210 220 230 240
>--
initn: 170 init1: 170 opt: 170 Z-score: 229.5 bits: 49.4 E(85289): 4.8e-06
Smith-Waterman score: 170; 87.1% identity (96.8% similar) in 31 aa overlap (115-145:208-238)
90 100 110 120 130 140
pF1KE6 CKLDEKDIPTRLLLSYDYHSPYTMDCHRAKASLAGTLSLMLVSTVLEFCLAVLTAVLQWK
:::::::::::. :.::::::::::::.::
XP_005 ELDKNNIPTRSYVSYFYHDSLYTTDCYTAKASLAGTLSLMLICTLLEFCLAVLTAVLRWK
180 190 200 210 220 230
pF1KE6 QTV
:
XP_005 QAYSDFPGSVLFLPHSYIGNSGMSSKMTHDCGYEELLTS
240 250 260 270
>>XP_016873613 (OMIM: 606548) PREDICTED: membrane-spanni (180 aa)
initn: 512 init1: 277 opt: 283 Z-score: 381.3 bits: 76.8 E(85289): 1.7e-14
Smith-Waterman score: 687; 70.9% identity (82.4% similar) in 165 aa overlap (1-145:1-165)
10 20 30 40
pF1KE6 MTSQPISNETIIMLPSNVINFSQAEKPEPTNQGQDSLKKRLQAKVKVIG-----------
:::::. :::::.::::::::::::::::::::::::::.:.:..::::
XP_016 MTSQPVPNETIIVLPSNVINFSQAEKPEPTNQGQDSLKKHLHAEIKVIGFIISGSLSIAT
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE6 --------VHSSLAGSILSALSALVGFILLSVNPAALNPASLQCKLDEKDIPTRLLLSYD
:::::.::::::::::::::.:::. :.::::::::.::...:::: .::
XP_016 EKRLTKLLVHSSLVGSILSALSALVGFIILSVKQATLNPASLQCELDKNNIPTRSYVSYF
70 80 90 100 110 120
110 120 130 140
pF1KE6 YH-SPYTMDCHRAKASLAGTLSLMLVSTVLEFCLAVLTAVLQWKQTV
:: : :: ::. :::::::::::::. :.::::::::::::.:::
XP_016 YHDSLYTTDCYTAKASLAGTLSLMLICTLLEFCLAVLTAVLRWKQAYSDFPGVSVLAGFT
130 140 150 160 170 180
147 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 13:59:53 2016 done: Tue Nov 8 13:59:54 2016
Total Scan time: 3.250 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]