Result of FASTA (omim) for
pFN21AE6495
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6495, 458 aa
1>>>pF1KE6495 458 - 458 aa - 458 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1748+/-0.000325; mu= 18.7462+/- 0.020
mean_var=73.3065+/-14.942, 0's: 0 Z-trim(116.0): 154 B-trim: 0 in 0/52
Lambda= 0.149797
statistics sampled from 26743 (26916) to 26743 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.677), E-opt: 0.2 (0.316), width: 16
Scan time: 9.830
The best scores are: opt bits E(85289)
NP_001094832 (OMIM: 609273,613727) kelch repeat an ( 458) 3111 681.6 1.2e-195
NP_061335 (OMIM: 611201) kelch-like protein 9 [Hom ( 617) 335 81.8 5.9e-15
NP_001003760 (OMIM: 610749) kelch-like protein 31 ( 634) 316 77.7 1e-13
XP_005249164 (OMIM: 610749) PREDICTED: kelch-like ( 634) 316 77.7 1e-13
XP_016866347 (OMIM: 610749) PREDICTED: kelch-like ( 634) 316 77.7 1e-13
NP_001161775 (OMIM: 300655) kelch-like protein 13 ( 613) 313 77.0 1.6e-13
NP_001161773 (OMIM: 300655) kelch-like protein 13 ( 639) 313 77.0 1.6e-13
NP_001161774 (OMIM: 300655) kelch-like protein 13 ( 639) 313 77.0 1.6e-13
XP_016885439 (OMIM: 300655) PREDICTED: kelch-like ( 639) 313 77.0 1.6e-13
NP_001161772 (OMIM: 300655) kelch-like protein 13 ( 649) 313 77.0 1.6e-13
NP_277030 (OMIM: 300655) kelch-like protein 13 iso ( 655) 313 77.0 1.7e-13
XP_011529713 (OMIM: 300655) PREDICTED: kelch-like ( 655) 313 77.0 1.7e-13
NP_001161771 (OMIM: 300655) kelch-like protein 13 ( 658) 313 77.0 1.7e-13
XP_011529711 (OMIM: 300655) PREDICTED: kelch-like ( 661) 313 77.0 1.7e-13
XP_011529712 (OMIM: 300655) PREDICTED: kelch-like ( 661) 313 77.0 1.7e-13
NP_001165125 (OMIM: 608064) kelch-like protein 5 i ( 568) 310 76.3 2.3e-13
NP_950240 (OMIM: 608064) kelch-like protein 5 isof ( 694) 310 76.4 2.7e-13
NP_001007076 (OMIM: 608064) kelch-like protein 5 i ( 709) 310 76.4 2.8e-13
NP_057074 (OMIM: 608064) kelch-like protein 5 isof ( 755) 310 76.4 2.9e-13
XP_011512003 (OMIM: 608064) PREDICTED: kelch-like ( 788) 310 76.4 3e-13
XP_016863764 (OMIM: 608064) PREDICTED: kelch-like ( 788) 310 76.4 3e-13
XP_016863765 (OMIM: 608064) PREDICTED: kelch-like ( 788) 310 76.4 3e-13
XP_011512002 (OMIM: 608064) PREDICTED: kelch-like ( 788) 310 76.4 3e-13
XP_005262712 (OMIM: 608064) PREDICTED: kelch-like ( 789) 310 76.4 3e-13
XP_016863763 (OMIM: 608064) PREDICTED: kelch-like ( 804) 310 76.4 3e-13
XP_011512001 (OMIM: 608064) PREDICTED: kelch-like ( 804) 310 76.4 3e-13
XP_016863762 (OMIM: 608064) PREDICTED: kelch-like ( 804) 310 76.4 3e-13
XP_005244900 (OMIM: 609209) PREDICTED: influenza v ( 424) 267 66.9 1.2e-10
XP_016855573 (OMIM: 609209) PREDICTED: influenza v ( 431) 267 67.0 1.2e-10
XP_011507382 (OMIM: 609209) PREDICTED: influenza v ( 560) 267 67.0 1.4e-10
NP_006460 (OMIM: 609209) influenza virus NS1A-bind ( 642) 267 67.1 1.6e-10
XP_011507381 (OMIM: 609209) PREDICTED: influenza v ( 649) 267 67.1 1.6e-10
XP_016876168 (OMIM: 605332) PREDICTED: kelch-like ( 525) 263 66.2 2.5e-10
XP_016876167 (OMIM: 605332) PREDICTED: kelch-like ( 575) 263 66.2 2.7e-10
NP_001278936 (OMIM: 611967) kelch-like protein 8 i ( 437) 261 65.7 2.9e-10
NP_001273654 (OMIM: 605332) kelch-like protein 1 i ( 687) 263 66.2 3.1e-10
NP_065917 (OMIM: 605332) kelch-like protein 1 isof ( 748) 263 66.3 3.3e-10
NP_001278935 (OMIM: 611967) kelch-like protein 8 i ( 544) 261 65.7 3.5e-10
NP_065854 (OMIM: 611967) kelch-like protein 8 isof ( 620) 261 65.8 3.8e-10
NP_001278932 (OMIM: 611967) kelch-like protein 8 i ( 620) 261 65.8 3.8e-10
NP_065856 (OMIM: 613772) kelch-like protein 14 [Ho ( 628) 260 65.6 4.5e-10
NP_061990 (OMIM: 300348) kelch-like protein 4 isof ( 718) 243 61.9 6.4e-09
NP_476503 (OMIM: 300348) kelch-like protein 4 isof ( 720) 243 61.9 6.4e-09
XP_016862151 (OMIM: 611295) PREDICTED: kelch-like ( 319) 231 59.1 2.1e-08
XP_016862152 (OMIM: 611295) PREDICTED: kelch-like ( 319) 231 59.1 2.1e-08
NP_001311238 (OMIM: 616262) kelch-like protein 21 ( 500) 231 59.2 2.9e-08
NP_055666 (OMIM: 616262) kelch-like protein 21 iso ( 597) 231 59.3 3.3e-08
XP_005247611 (OMIM: 611295) PREDICTED: kelch-like ( 600) 231 59.3 3.3e-08
XP_011511240 (OMIM: 611295) PREDICTED: kelch-like ( 600) 231 59.3 3.3e-08
XP_005247609 (OMIM: 611295) PREDICTED: kelch-like ( 600) 231 59.3 3.3e-08
>>NP_001094832 (OMIM: 609273,613727) kelch repeat and BT (458 aa)
initn: 3111 init1: 3111 opt: 3111 Z-score: 3633.6 bits: 681.6 E(85289): 1.2e-195
Smith-Waterman score: 3111; 99.8% identity (100.0% similar) in 458 aa overlap (1-458:1-458)
10 20 30 40 50 60
pF1KE6 MARGPQTLVQVWVGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MARGPQTLVQVWVGGQLFQADRALLVEHCGFFRGLFRSGMRETRAAEVRLGVLSAGGFRA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 TLQVLRGDRPALAAEDELLQVVECAAFLQAPALARFLEHNLTSDNCALLCDAAAAFGLRD
::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::
NP_001 TLQVLRGDRPALAAEDELLQAVECAAFLQAPALARFLEHNLTSDNCALLCDAAAAFGLRD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 VFHSAALFICDGERELAAELALPEARAYVAALRPSSYAAVSTHTPAPGFLEDASRTLCYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VFHSAALFICDGERELAAELALPEARAYVAALRPSSYAAVSTHTPAPGFLEDASRTLCYL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 DEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASKEVVELGFCYDPDGGTWHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRGASKEVVELGFCYDPDGGTWHE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 FPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPC
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 AQACGRLFVCLWRPADTTAVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRNGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AQACGRLFVCLWRPADTTAVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRNGP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 SDDFLHCAIDCLNLATGQWTALPGQFVNSKGALFTAVVRGDTVYTVNRMFTLLYAIEGGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDDFLHCAIDCLNLATGQWTALPGQFVNSKGALFTAVVRGDTVYTVNRMFTLLYAIEGGT
370 380 390 400 410 420
430 440 450
pF1KE6 WRLLREKAGFPRPGSLQTFLLRLPPGAPGPVTSTTAEL
::::::::::::::::::::::::::::::::::::::
NP_001 WRLLREKAGFPRPGSLQTFLLRLPPGAPGPVTSTTAEL
430 440 450
>>NP_061335 (OMIM: 611201) kelch-like protein 9 [Homo sa (617 aa)
initn: 324 init1: 153 opt: 335 Z-score: 389.5 bits: 81.8 E(85289): 5.9e-15
Smith-Waterman score: 339; 28.3% identity (53.1% similar) in 339 aa overlap (148-456:281-612)
120 130 140 150 160 170
pF1KE6 LRDVFHSAALFICDGERELAAELALPEARAYVAALRPSSYAAV---STH-TPAPGFLED-
:. . :. .:. ::: . : :..
NP_061 INYVQTVDFMRTDNTCVNLLLEASNYQMMPYMQPVMQSDRTAIRSDSTHLVTLGGVLRQQ
260 270 280 290 300 310
180 190 200 210 220
pF1KE6 --ASRTLCYLDEEEDAWRTLAALPLEASTLLAGVATLGNKLYIVGGVRG---ASKEVVEL
.:. : . ::. . ::.:: :..: :.:..:: ::.::: . .: .:.
NP_061 LVVSKELRMYDERAQEWRSLA--PMDAPRYQHGIAVIGNFLYVVGGQSNYDTKGKTAVDT
320 330 340 350 360
230 240 250 260 270 280
pF1KE6 GFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSF
: .:: . : . : .. : :... :.:::.::. ...:: :.: . ::.
NP_061 VFRFDPRYNKWMQVASLNEKRTFFHLSALKGHLYAVGGRSAAGELATVECYNPRMNEWSY
370 380 390 400 410 420
290 300 310 320 330 340
pF1KE6 VADLPQPAAGVPCAQACGRLFVCLWRPADT--TAVVEYAVRTDAWLPVAELRRPQSYGHC
:: . .: : . : ... :: . .. . :: :. : . .. ::
NP_061 VAKMSEPHYGHAGTVYGGLMYISGGITHDTFQNELMCFDPDTDKWMQKAPMTTVRGL-HC
430 440 450 460 470 480
350 360 370 380 390
pF1KE6 MVAHRDSLYVVRN----GPSD--DFLHCAIDCLNLATGQWTALPGQFVNSKGALFTAVVR
: . :.:::. . : :: : : : .: ::: . ... ... . .:: .
NP_061 MCTVGDKLYVIGGNHFRGTSDYDDVLSCEYYSPTL--DQWTPIAAML-RGQSDVGVAVFE
490 500 510 520 530 540
400 410 420 430 440
pF1KE6 GDTVYTV------NR-MFTLL--YAIEGGTWRL---LREKAGFPRPGSLQTFLLRLPPGA
. .:.: :: : .. : : :. : :. : : .: .: . ::.
NP_061 -NKIYVVGGYSWNNRCMVEIVQKYDPEKDEWHKVFDLPESLGGIRACTLTVFPPEENPGS
550 560 570 580 590 600
450
pF1KE6 PGPVTSTTAEL
:. . .:
NP_061 PSRESPLSAPSDHS
610
>>NP_001003760 (OMIM: 610749) kelch-like protein 31 [Hom (634 aa)
initn: 250 init1: 124 opt: 316 Z-score: 367.2 bits: 77.7 E(85289): 1e-13
Smith-Waterman score: 316; 30.8% identity (57.1% similar) in 247 aa overlap (167-391:325-559)
140 150 160 170 180 190
pF1KE6 AAELALPEARAYVAALRPSSYAAVSTHTPAPGFLEDA-SRTLCYLDEEEDAWRTLAALPL
::. : . :: . : : : ..: :. .:
NP_001 HLLPYHQNTLQSRRTRIRGGCRVLVTVGGRPGLTEKSLSRDILYRDPE-NGWSKLTEMP-
300 310 320 330 340 350
200 210 220 230 240
pF1KE6 EASTLLAGVATLGNKLYIVGG-----VRGASKEVVELGFC-YDPDGGTWHEFPSPHQPRY
:... ::.. . ::..:: .:. .:..: .:: ::: .:: .. : .: :
NP_001 -AKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVS-NFCRYDPRFNTWIHLASMNQKRT
360 370 380 390 400 410
250 260 270 280 290 300
pF1KE6 DTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQAC-----
.:. :.: .:: ::. . ..:.: : :... : :: . . :. :
NP_001 HFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQW-------QPKTPLEVARCCHASAV
420 430 440 450 460
310 320 330 340 350
pF1KE6 --GRLFVCLWRPAD--TTAVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRN--
::..: :. . .: : .:.: . .: :... :: :. : .::. .
NP_001 ADGRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLSTPRGW-HCAVTLSDRVYVMGGSQ
470 480 490 500 510 520
360 370 380 390 400 410
pF1KE6 -GPSDDFLHC-AIDCLNLATGQWT-ALPGQF-VNSKGALFTAVVRGDTVYTVNRMFTLLY
:: . . ...: . :::::. : : : :.. :
NP_001 LGPRGERVDVLTVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKK
530 540 550 560 570 580
420 430 440 450
pF1KE6 AIEGGTWRLLREKAGFPRPGSLQTFLLRLPPGAPGPVTSTTAEL
NP_001 CIQCFSPELNEWTEDDELPEATVGVSCCTLSMPNNVTRESRASSVSSVPVSI
590 600 610 620 630
>>XP_005249164 (OMIM: 610749) PREDICTED: kelch-like prot (634 aa)
initn: 250 init1: 124 opt: 316 Z-score: 367.2 bits: 77.7 E(85289): 1e-13
Smith-Waterman score: 316; 30.8% identity (57.1% similar) in 247 aa overlap (167-391:325-559)
140 150 160 170 180 190
pF1KE6 AAELALPEARAYVAALRPSSYAAVSTHTPAPGFLEDA-SRTLCYLDEEEDAWRTLAALPL
::. : . :: . : : : ..: :. .:
XP_005 HLLPYHQNTLQSRRTRIRGGCRVLVTVGGRPGLTEKSLSRDILYRDPE-NGWSKLTEMP-
300 310 320 330 340 350
200 210 220 230 240
pF1KE6 EASTLLAGVATLGNKLYIVGG-----VRGASKEVVELGFC-YDPDGGTWHEFPSPHQPRY
:... ::.. . ::..:: .:. .:..: .:: ::: .:: .. : .: :
XP_005 -AKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVS-NFCRYDPRFNTWIHLASMNQKRT
360 370 380 390 400 410
250 260 270 280 290 300
pF1KE6 DTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQAC-----
.:. :.: .:: ::. . ..:.: : :... : :: . . :. :
XP_005 HFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQW-------QPKTPLEVARCCHASAV
420 430 440 450 460
310 320 330 340 350
pF1KE6 --GRLFVCLWRPAD--TTAVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRN--
::..: :. . .: : .:.: . .: :... :: :. : .::. .
XP_005 ADGRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLSTPRGW-HCAVTLSDRVYVMGGSQ
470 480 490 500 510 520
360 370 380 390 400 410
pF1KE6 -GPSDDFLHC-AIDCLNLATGQWT-ALPGQF-VNSKGALFTAVVRGDTVYTVNRMFTLLY
:: . . ...: . :::::. : : : :.. :
XP_005 LGPRGERVDVLTVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKK
530 540 550 560 570 580
420 430 440 450
pF1KE6 AIEGGTWRLLREKAGFPRPGSLQTFLLRLPPGAPGPVTSTTAEL
XP_005 CIQCFSPELNEWTEDDELPEATVGVSCCTLSMPNNVTRESRASSVSSVPVSI
590 600 610 620 630
>>XP_016866347 (OMIM: 610749) PREDICTED: kelch-like prot (634 aa)
initn: 250 init1: 124 opt: 316 Z-score: 367.2 bits: 77.7 E(85289): 1e-13
Smith-Waterman score: 316; 30.8% identity (57.1% similar) in 247 aa overlap (167-391:325-559)
140 150 160 170 180 190
pF1KE6 AAELALPEARAYVAALRPSSYAAVSTHTPAPGFLEDA-SRTLCYLDEEEDAWRTLAALPL
::. : . :: . : : : ..: :. .:
XP_016 HLLPYHQNTLQSRRTRIRGGCRVLVTVGGRPGLTEKSLSRDILYRDPE-NGWSKLTEMP-
300 310 320 330 340 350
200 210 220 230 240
pF1KE6 EASTLLAGVATLGNKLYIVGG-----VRGASKEVVELGFC-YDPDGGTWHEFPSPHQPRY
:... ::.. . ::..:: .:. .:..: .:: ::: .:: .. : .: :
XP_016 -AKSFNQCVAVMDGFLYVAGGEDQNDARNQAKHAVS-NFCRYDPRFNTWIHLASMNQKRT
360 370 380 390 400 410
250 260 270 280 290 300
pF1KE6 DTALAGFDGRLYAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQAC-----
.:. :.: .:: ::. . ..:.: : :... : :: . . :. :
XP_016 HFSLSVFNGLVYAAGGRNAEGSLASLECYVPSTNQW-------QPKTPLEVARCCHASAV
420 430 440 450 460
310 320 330 340 350
pF1KE6 --GRLFVCLWRPAD--TTAVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRN--
::..: :. . .: : .:.: . .: :... :: :. : .::. .
XP_016 ADGRVLVTGGYIANAYSRSVCAYDPASDSWQELPNLSTPRGW-HCAVTLSDRVYVMGGSQ
470 480 490 500 510 520
360 370 380 390 400 410
pF1KE6 -GPSDDFLHC-AIDCLNLATGQWT-ALPGQF-VNSKGALFTAVVRGDTVYTVNRMFTLLY
:: . . ...: . :::::. : : : :.. :
XP_016 LGPRGERVDVLTVECYSPATGQWSYAAPLQVGVSTAGVSALHGRAYLVGGWNEGEKKYKK
530 540 550 560 570 580
420 430 440 450
pF1KE6 AIEGGTWRLLREKAGFPRPGSLQTFLLRLPPGAPGPVTSTTAEL
XP_016 CIQCFSPELNEWTEDDELPEATVGVSCCTLSMPNNVTRESRASSVSSVPVSI
590 600 610 620 630
>>NP_001161775 (OMIM: 300655) kelch-like protein 13 isof (613 aa)
initn: 289 init1: 147 opt: 313 Z-score: 363.9 bits: 77.0 E(85289): 1.6e-13
Smith-Waterman score: 313; 27.4% identity (51.7% similar) in 259 aa overlap (174-421:314-555)
150 160 170 180 190 200
pF1KE6 EARAYVAALRPSSYAAVSTHTPAPGFLEDASRTLCYLDEEEDAWRTLAALPLEASTLLAG
:. : . ::. :..:: :..: :
NP_001 PVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLA--PMDAPRYQHG
290 300 310 320 330 340
210 220 230 240 250 260
pF1KE6 VATLGNKLYIVGGVRG---ASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRL
.:..:: ::.::: . .: .:. : .:: . : . : .. : :... : :
NP_001 IAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYL
350 360 370 380 390 400
270 280 290 300 310
pF1KE6 YAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVCLWRPADT--T
::.::. . .:: :.: .. :..:: . .: : . : ... ::
NP_001 YAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQK
410 420 430 440 450 460
320 330 340 350 360 370
pF1KE6 AVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRN----GPSD--DFLHCAIDCL
.. . :: :. : . .. ::: . . :::. . : :: : : : .
NP_001 ELMCFDPDTDKWIQKAPMTTVRGL-HCMCTVGERLYVIGGNHFRGTSDYDDVLSC--EYY
470 480 490 500 510
380 390 400 410 420 430
pF1KE6 NLATGQWTALPGQFVNSKGALFTAVVRGDTVYTVNRMFTLLYAIEGGTWRLLREKAGFPR
. ::: . .:..::.. : . . .:.. : .:
NP_001 SPILDQWTPI------------AAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQK
520 530 540 550 560
440 450
pF1KE6 PGSLQTFLLRLPPGAPGPVTSTTAEL
NP_001 YDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
570 580 590 600 610
>>NP_001161773 (OMIM: 300655) kelch-like protein 13 isof (639 aa)
initn: 289 init1: 147 opt: 313 Z-score: 363.6 bits: 77.0 E(85289): 1.6e-13
Smith-Waterman score: 313; 27.4% identity (51.7% similar) in 259 aa overlap (174-421:340-581)
150 160 170 180 190 200
pF1KE6 EARAYVAALRPSSYAAVSTHTPAPGFLEDASRTLCYLDEEEDAWRTLAALPLEASTLLAG
:. : . ::. :..:: :..: :
NP_001 PVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLA--PMDAPRYQHG
310 320 330 340 350 360
210 220 230 240 250 260
pF1KE6 VATLGNKLYIVGGVRG---ASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRL
.:..:: ::.::: . .: .:. : .:: . : . : .. : :... : :
NP_001 IAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYL
370 380 390 400 410 420
270 280 290 300 310
pF1KE6 YAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVCLWRPADT--T
::.::. . .:: :.: .. :..:: . .: : . : ... ::
NP_001 YAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQK
430 440 450 460 470 480
320 330 340 350 360 370
pF1KE6 AVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRN----GPSD--DFLHCAIDCL
.. . :: :. : . .. ::: . . :::. . : :: : : : .
NP_001 ELMCFDPDTDKWIQKAPMTTVRGL-HCMCTVGERLYVIGGNHFRGTSDYDDVLSC--EYY
490 500 510 520 530 540
380 390 400 410 420 430
pF1KE6 NLATGQWTALPGQFVNSKGALFTAVVRGDTVYTVNRMFTLLYAIEGGTWRLLREKAGFPR
. ::: . .:..::.. : . . .:.. : .:
NP_001 SPILDQWTPI------------AAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQK
550 560 570 580 590
440 450
pF1KE6 PGSLQTFLLRLPPGAPGPVTSTTAEL
NP_001 YDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
600 610 620 630
>>NP_001161774 (OMIM: 300655) kelch-like protein 13 isof (639 aa)
initn: 289 init1: 147 opt: 313 Z-score: 363.6 bits: 77.0 E(85289): 1.6e-13
Smith-Waterman score: 313; 27.4% identity (51.7% similar) in 259 aa overlap (174-421:340-581)
150 160 170 180 190 200
pF1KE6 EARAYVAALRPSSYAAVSTHTPAPGFLEDASRTLCYLDEEEDAWRTLAALPLEASTLLAG
:. : . ::. :..:: :..: :
NP_001 PVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLA--PMDAPRYQHG
310 320 330 340 350 360
210 220 230 240 250 260
pF1KE6 VATLGNKLYIVGGVRG---ASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRL
.:..:: ::.::: . .: .:. : .:: . : . : .. : :... : :
NP_001 IAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYL
370 380 390 400 410 420
270 280 290 300 310
pF1KE6 YAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVCLWRPADT--T
::.::. . .:: :.: .. :..:: . .: : . : ... ::
NP_001 YAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQK
430 440 450 460 470 480
320 330 340 350 360 370
pF1KE6 AVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRN----GPSD--DFLHCAIDCL
.. . :: :. : . .. ::: . . :::. . : :: : : : .
NP_001 ELMCFDPDTDKWIQKAPMTTVRGL-HCMCTVGERLYVIGGNHFRGTSDYDDVLSC--EYY
490 500 510 520 530 540
380 390 400 410 420 430
pF1KE6 NLATGQWTALPGQFVNSKGALFTAVVRGDTVYTVNRMFTLLYAIEGGTWRLLREKAGFPR
. ::: . .:..::.. : . . .:.. : .:
NP_001 SPILDQWTPI------------AAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQK
550 560 570 580 590
440 450
pF1KE6 PGSLQTFLLRLPPGAPGPVTSTTAEL
NP_001 YDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
600 610 620 630
>>XP_016885439 (OMIM: 300655) PREDICTED: kelch-like prot (639 aa)
initn: 289 init1: 147 opt: 313 Z-score: 363.6 bits: 77.0 E(85289): 1.6e-13
Smith-Waterman score: 313; 27.4% identity (51.7% similar) in 259 aa overlap (174-421:340-581)
150 160 170 180 190 200
pF1KE6 EARAYVAALRPSSYAAVSTHTPAPGFLEDASRTLCYLDEEEDAWRTLAALPLEASTLLAG
:. : . ::. :..:: :..: :
XP_016 PVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLA--PMDAPRYQHG
310 320 330 340 350 360
210 220 230 240 250 260
pF1KE6 VATLGNKLYIVGGVRG---ASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRL
.:..:: ::.::: . .: .:. : .:: . : . : .. : :... : :
XP_016 IAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYL
370 380 390 400 410 420
270 280 290 300 310
pF1KE6 YAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVCLWRPADT--T
::.::. . .:: :.: .. :..:: . .: : . : ... ::
XP_016 YAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQK
430 440 450 460 470 480
320 330 340 350 360 370
pF1KE6 AVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRN----GPSD--DFLHCAIDCL
.. . :: :. : . .. ::: . . :::. . : :: : : : .
XP_016 ELMCFDPDTDKWIQKAPMTTVRGL-HCMCTVGERLYVIGGNHFRGTSDYDDVLSC--EYY
490 500 510 520 530 540
380 390 400 410 420 430
pF1KE6 NLATGQWTALPGQFVNSKGALFTAVVRGDTVYTVNRMFTLLYAIEGGTWRLLREKAGFPR
. ::: . .:..::.. : . . .:.. : .:
XP_016 SPILDQWTPI------------AAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQK
550 560 570 580 590
440 450
pF1KE6 PGSLQTFLLRLPPGAPGPVTSTTAEL
XP_016 YDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
600 610 620 630
>>NP_001161772 (OMIM: 300655) kelch-like protein 13 isof (649 aa)
initn: 289 init1: 147 opt: 313 Z-score: 363.5 bits: 77.0 E(85289): 1.6e-13
Smith-Waterman score: 313; 27.4% identity (51.7% similar) in 259 aa overlap (174-421:350-591)
150 160 170 180 190 200
pF1KE6 EARAYVAALRPSSYAAVSTHTPAPGFLEDASRTLCYLDEEEDAWRTLAALPLEASTLLAG
:. : . ::. :..:: :..: :
NP_001 PVMQSDRTAIRSDTTHLVTLGGVLRQQLVVSKELRMYDEKAHEWKSLA--PMDAPRYQHG
320 330 340 350 360 370
210 220 230 240 250 260
pF1KE6 VATLGNKLYIVGGVRG---ASKEVVELGFCYDPDGGTWHEFPSPHQPRYDTALAGFDGRL
.:..:: ::.::: . .: .:. : .:: . : . : .. : :... : :
NP_001 IAVIGNFLYVVGGQSNYDTKGKTAVDTVFRFDPRYNKWMQVASLNEKRTFFHLSALKGYL
380 390 400 410 420 430
270 280 290 300 310
pF1KE6 YAIGGEFQRTPISSVERYDPAAGCWSFVADLPQPAAGVPCAQACGRLFVCLWRPADT--T
::.::. . .:: :.: .. :..:: . .: : . : ... ::
NP_001 YAVGGRNAAGELPTVECYNPRTNEWTYVAKMSEPHYGHAGTVYGGVMYISGGITHDTFQK
440 450 460 470 480 490
320 330 340 350 360 370
pF1KE6 AVVEYAVRTDAWLPVAELRRPQSYGHCMVAHRDSLYVVRN----GPSD--DFLHCAIDCL
.. . :: :. : . .. ::: . . :::. . : :: : : : .
NP_001 ELMCFDPDTDKWIQKAPMTTVRGL-HCMCTVGERLYVIGGNHFRGTSDYDDVLSC--EYY
500 510 520 530 540 550
380 390 400 410 420 430
pF1KE6 NLATGQWTALPGQFVNSKGALFTAVVRGDTVYTVNRMFTLLYAIEGGTWRLLREKAGFPR
. ::: . .:..::.. : . . .:.. : .:
NP_001 SPILDQWTPI------------AAMLRGQSDVGVAVFENKIYVVGGYSWNNRCMVEIVQK
560 570 580 590 600
440 450
pF1KE6 PGSLQTFLLRLPPGAPGPVTSTTAEL
NP_001 YDPDKDEWHKVFDLPESLGGIRACTLTVFPPEETTPSPSRESPLSAP
610 620 630 640
458 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 13:52:17 2016 done: Tue Nov 8 13:52:18 2016
Total Scan time: 9.830 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]