Result of FASTA (omim) for
pFN21AE6486
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6486, 584 aa
1>>>pF1KE6486 584 - 584 aa - 584 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1925+/-0.000431; mu= 19.1382+/- 0.026
mean_var=68.6510+/-14.257, 0's: 0 Z-trim(110.9): 57 B-trim: 11 in 1/53
Lambda= 0.154793
statistics sampled from 19271 (19325) to 19271 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.577), E-opt: 0.2 (0.227), width: 16
Scan time: 9.260
The best scores are: opt bits E(85289)
XP_011537051 (OMIM: 609841) PREDICTED: sodium/pota ( 584) 3888 878.0 0
NP_079235 (OMIM: 609841) sodium/potassium/calcium ( 584) 3888 878.0 0
XP_016875467 (OMIM: 609841) PREDICTED: sodium/pota ( 422) 2824 640.3 3.9e-183
XP_011537054 (OMIM: 609841) PREDICTED: sodium/pota ( 389) 2579 585.5 1.1e-166
XP_006719670 (OMIM: 609841) PREDICTED: sodium/pota ( 389) 2579 585.5 1.1e-166
NP_001317395 (OMIM: 609841) sodium/potassium/calci ( 528) 2345 533.3 7.3e-151
NP_065740 (OMIM: 609839) sodium/potassium/calcium ( 644) 289 74.3 1.4e-12
XP_011534743 (OMIM: 210750,609840,615887) PREDICTE ( 316) 275 70.9 7e-12
XP_011534744 (OMIM: 210750,609840,615887) PREDICTE ( 316) 275 70.9 7e-12
XP_011534742 (OMIM: 210750,609840,615887) PREDICTE ( 372) 275 71.0 8e-12
NP_705934 (OMIM: 210750,609840,615887) sodium/pota ( 558) 275 71.1 1.1e-11
NP_705933 (OMIM: 210750,609840,615887) sodium/pota ( 603) 275 71.1 1.2e-11
NP_705932 (OMIM: 210750,609840,615887) sodium/pota ( 622) 275 71.1 1.2e-11
XP_011534739 (OMIM: 210750,609840,615887) PREDICTE ( 650) 275 71.1 1.2e-11
XP_011534738 (OMIM: 210750,609840,615887) PREDICTE ( 669) 275 71.1 1.3e-11
XP_011520528 (OMIM: 603617,613830) PREDICTED: sodi ( 688) 272 70.5 2.1e-11
XP_005254838 (OMIM: 603617,613830) PREDICTED: sodi ( 717) 272 70.5 2.1e-11
XP_016878214 (OMIM: 603617,613830) PREDICTED: sodi ( 966) 272 70.6 2.7e-11
NP_001241669 (OMIM: 603617,613830) sodium/potassiu ( 426) 251 65.7 3.6e-10
NP_995322 (OMIM: 113750,609802) sodium/potassium/c ( 500) 251 65.7 4.1e-10
XP_006720831 (OMIM: 603617,613830) PREDICTED: sodi ( 985) 251 65.9 7.2e-10
NP_001287961 (OMIM: 603617,613830) sodium/potassiu (1081) 251 65.9 7.7e-10
XP_011520522 (OMIM: 603617,613830) PREDICTED: sodi (1081) 251 65.9 7.7e-10
XP_005254835 (OMIM: 603617,613830) PREDICTED: sodi (1099) 251 65.9 7.8e-10
XP_011520521 (OMIM: 603617,613830) PREDICTED: sodi (1099) 251 65.9 7.8e-10
NP_004718 (OMIM: 603617,613830) sodium/potassium/c (1099) 251 65.9 7.8e-10
XP_016870082 (OMIM: 609838) PREDICTED: sodium/pota ( 644) 245 64.4 1.3e-09
XP_006716813 (OMIM: 609838) PREDICTED: sodium/pota ( 644) 245 64.4 1.3e-09
NP_001180217 (OMIM: 609838) sodium/potassium/calci ( 644) 245 64.4 1.3e-09
NP_065077 (OMIM: 609838) sodium/potassium/calcium ( 661) 245 64.4 1.3e-09
XP_005251483 (OMIM: 609838) PREDICTED: sodium/pota ( 661) 245 64.4 1.3e-09
XP_005251482 (OMIM: 609838) PREDICTED: sodium/pota ( 661) 245 64.4 1.3e-09
XP_016870081 (OMIM: 609838) PREDICTED: sodium/pota ( 661) 245 64.4 1.3e-09
NP_001287960 (OMIM: 603617,613830) sodium/potassiu (1069) 235 62.3 9.1e-09
XP_011520523 (OMIM: 603617,613830) PREDICTED: sodi (1069) 235 62.3 9.1e-09
XP_011534741 (OMIM: 210750,609840,615887) PREDICTE ( 626) 221 59.1 5.2e-08
XP_011534740 (OMIM: 210750,609840,615887) PREDICTE ( 645) 221 59.1 5.3e-08
NP_001287962 (OMIM: 603617,613830) sodium/potassiu (1012) 189 52.1 1.1e-05
XP_011520524 (OMIM: 603617,613830) PREDICTED: sodi (1030) 189 52.1 1.1e-05
XP_016878213 (OMIM: 603617,613830) PREDICTED: sodi (1049) 180 50.1 4.5e-05
XP_016877569 (OMIM: 113750,609802) PREDICTED: sodi ( 314) 147 42.3 0.0028
XP_016877568 (OMIM: 113750,609802) PREDICTED: sodi ( 314) 147 42.3 0.0028
>>XP_011537051 (OMIM: 609841) PREDICTED: sodium/potassiu (584 aa)
initn: 3888 init1: 3888 opt: 3888 Z-score: 4691.0 bits: 878.0 E(85289): 0
Smith-Waterman score: 3888; 100.0% identity (100.0% similar) in 584 aa overlap (1-584:1-584)
10 20 30 40 50 60
pF1KE6 MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 VSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 FFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 VTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 VVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQET
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 TAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 LHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 FAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLAR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 QGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVF
490 500 510 520 530 540
550 560 570 580
pF1KE6 SLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM
::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM
550 560 570 580
>>NP_079235 (OMIM: 609841) sodium/potassium/calcium exch (584 aa)
initn: 3888 init1: 3888 opt: 3888 Z-score: 4691.0 bits: 878.0 E(85289): 0
Smith-Waterman score: 3888; 100.0% identity (100.0% similar) in 584 aa overlap (1-584:1-584)
10 20 30 40 50 60
pF1KE6 MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 VSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 VSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 FFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 FFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 VTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 VTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 VVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 VVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQET
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 TAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 TAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 LHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 LHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 FAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 FAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLAR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 QGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 QGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVF
490 500 510 520 530 540
550 560 570 580
pF1KE6 SLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM
::::::::::::::::::::::::::::::::::::::::::::
NP_079 SLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM
550 560 570 580
>>XP_016875467 (OMIM: 609841) PREDICTED: sodium/potassiu (422 aa)
initn: 2824 init1: 2824 opt: 2824 Z-score: 3408.9 bits: 640.3 E(85289): 3.9e-183
Smith-Waterman score: 2824; 99.8% identity (100.0% similar) in 420 aa overlap (1-420:1-420)
10 20 30 40 50 60
pF1KE6 MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 VSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 FFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 VTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFY
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 VVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQET
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 TAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNC
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 LHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::.
XP_016 LHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 FAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLAR
XP_016 RN
>>XP_011537054 (OMIM: 609841) PREDICTED: sodium/potassiu (389 aa)
initn: 2579 init1: 2579 opt: 2579 Z-score: 3113.7 bits: 585.5 E(85289): 1.1e-166
Smith-Waterman score: 2579; 100.0% identity (100.0% similar) in 389 aa overlap (196-584:1-389)
170 180 190 200 210 220
pF1KE6 TAGLALGALFGAGVLVTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRV
::::::::::::::::::::::::::::::
XP_011 MAASRPFFRDIVFYMVAVFLTFLMLFRGRV
10 20 30
230 240 250 260 270 280
pF1KE6 TLAWALGYLGLYVFYVVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLAWALGYLGLYVFYVVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSY
40 50 60 70 80 90
290 300 310 320 330 340
pF1KE6 DYGDEYRPLFFYQETTAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DYGDEYRPLFFYQETTAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVV
100 110 120 130 140 150
350 360 370 380 390 400
pF1KE6 DPDKDDQNWKRPLNCLHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DPDKDDQNWKRPLNCLHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVT
160 170 180 190 200 210
410 420 430 440 450 460
pF1KE6 FFATSDSQPPRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FFATSDSQPPRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAW
220 230 240 250 260 270
470 480 490 500 510 520
pF1KE6 GNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGL
280 290 300 310 320 330
530 540 550 560 570 580
pF1KE6 LVWVLAGALGLSLVFSLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVWVLAGALGLSLVFSLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM
340 350 360 370 380
>>XP_006719670 (OMIM: 609841) PREDICTED: sodium/potassiu (389 aa)
initn: 2579 init1: 2579 opt: 2579 Z-score: 3113.7 bits: 585.5 E(85289): 1.1e-166
Smith-Waterman score: 2579; 100.0% identity (100.0% similar) in 389 aa overlap (196-584:1-389)
170 180 190 200 210 220
pF1KE6 TAGLALGALFGAGVLVTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRV
::::::::::::::::::::::::::::::
XP_006 MAASRPFFRDIVFYMVAVFLTFLMLFRGRV
10 20 30
230 240 250 260 270 280
pF1KE6 TLAWALGYLGLYVFYVVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TLAWALGYLGLYVFYVVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSY
40 50 60 70 80 90
290 300 310 320 330 340
pF1KE6 DYGDEYRPLFFYQETTAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DYGDEYRPLFFYQETTAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVV
100 110 120 130 140 150
350 360 370 380 390 400
pF1KE6 DPDKDDQNWKRPLNCLHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DPDKDDQNWKRPLNCLHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVT
160 170 180 190 200 210
410 420 430 440 450 460
pF1KE6 FFATSDSQPPRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FFATSDSQPPRLHWLFAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAW
220 230 240 250 260 270
470 480 490 500 510 520
pF1KE6 GNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GNSIGDAFSDFTLARQGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGL
280 290 300 310 320 330
530 540 550 560 570 580
pF1KE6 LVWVLAGALGLSLVFSLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LVWVLAGALGLSLVFSLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM
340 350 360 370 380
>>NP_001317395 (OMIM: 609841) sodium/potassium/calcium e (528 aa)
initn: 2344 init1: 2344 opt: 2345 Z-score: 2829.4 bits: 533.3 E(85289): 7.3e-151
Smith-Waterman score: 3405; 90.4% identity (90.4% similar) in 584 aa overlap (1-584:1-528)
10 20 30 40 50 60
pF1KE6 MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 VSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 FFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFG----
130 140 150 160 170
190 200 210 220 230 240
pF1KE6 VTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFY
::::::::
NP_001 ----------------------------------------------------YLGLYVFY
180
250 260 270 280 290 300
pF1KE6 VVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQET
190 200 210 220 230 240
310 320 330 340 350 360
pF1KE6 TAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNC
250 260 270 280 290 300
370 380 390 400 410 420
pF1KE6 LHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWL
310 320 330 340 350 360
430 440 450 460 470 480
pF1KE6 FAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLAR
370 380 390 400 410 420
490 500 510 520 530 540
pF1KE6 QGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVF
430 440 450 460 470 480
550 560 570 580
pF1KE6 SLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM
::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM
490 500 510 520
>>NP_065740 (OMIM: 609839) sodium/potassium/calcium exch (644 aa)
initn: 445 init1: 234 opt: 289 Z-score: 346.7 bits: 74.3 E(85289): 1.4e-12
Smith-Waterman score: 409; 25.3% identity (54.7% similar) in 534 aa overlap (99-578:109-632)
70 80 90 100 110 120
pF1KE6 RTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAKFFCPNLSA
::.:.: .:.: :... :: :.:
NP_065 AGLRNSKNCTEPALHEFPNDIFTNEDRRQGAVVLHVLCAIYMFYALAIVCDDFFVPSLEK
80 90 100 110 120 130
130 140 150 160 170 180
pF1KE6 ISTTLKLSHNVAGVTFLAFGNGAPDIFSALVA-FSDPHTAGLALGALFGAGVLVTTVVAG
: :.::..:::.::.: :..::..:..... : .:. :.. :..:. . :
NP_065 ICERLHLSEDVAGATFMAAGSSAPELFTSVIGVFITKGDVGV--GTIVGSAVFNILCIIG
140 150 160 170 180 190
190 200 210 220 230 240
pF1KE6 --GITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFYVVTVI
:. . .: ..:: ..: ..:. ..... .:. .: . .:..:.: .
NP_065 VCGLFAGQVVALSSWCLLRDSIYYTLSVIALIVFIYDEKVSWWESLVLVLMYLIYIVIMK
200 210 220 230 240 250
250 260 270 280 290
pF1KE6 LCTWIYQ-RQRR----GSLFCPMPVTPEILSDSEEDRVSSNTNSYDYG--------DE--
. :.: .:: :.. . . :: ..:. : . .. .. ::
NP_065 YNACIHQCFERRTKGAGNMVNGLANNAEIDDSSNCDATVVLLKKANFHRKASVIMVDELL
260 270 280 290 300 310
300 310 320 330
pF1KE6 --YRPLFFYQETTAQILVRALNP----LDY-----MKWRRKSAYWKALK------VFKLP
: . ..:. .:.. . : :.. .. :.. .: ..:.:
NP_065 SAYPHQLSFSEAGLRIMITSHFPPKTRLSMASRMLINERQRLINSRAYTNGESEVAIKIP
320 330 340 350 360 370
340 350 360 370 380
pF1KE6 VEFLLLL-TVPVVDPDK-------DD-----QNWKRPLNCLHLVISPLVVVLTLQSGTYG
.. . : : ::. :: : . : . . : :
NP_065 IKHTVENGTGPSSAPDRGVNGTRRDDVVAEAGNETENENEDNENDEEEEEDEDDDEGPYT
380 390 400 410 420 430
390 400 410 420 430
pF1KE6 VYEI--GGLVPV-WVVVVIAGTALASVTFFATSDSQPPRLHWLFAFL-GFLTSALWINAA
.. : : : :. . :. : .:.. . . :: : :. : .:.::: :
NP_065 PFDTPSGKLETVKWAFT----WPLSFVLYFTVPNCNKPR--WEKWFMVTFASSTLWIAAF
440 450 460 470 480 490
440 450 460 470 480 490
pF1KE6 ATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSACFGGII
. .: .. .: .. . ....:.:.:: :.:. : .... .::::. :: : .:. .
NP_065 SYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGMGDMAVSNSIGSNV
500 510 520 530 540 550
500 510 520 530 540 550
pF1KE6 FNILVGVGLGCLLQ-ISRSH-TEVKLEPDGLLVWVLAGALGLSLVFSLVSVPLQCFQLSR
:.::.:.:: :: .. .. . ..:. ::. : : : :. .. .: :. .::..
NP_065 FDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSV--GLLLASVFVTVFGVHLNKWQLDK
560 570 580 590 600
560 570 580
pF1KE6 VYGFCLLLFYLNFLVVALLTEFGVIHLKSM
: ::.: :: ...:::.:
NP_065 KLGCGCLLLYGVFLCFSIMTEFNVFTFVNLPMCGDH
610 620 630 640
>>XP_011534743 (OMIM: 210750,609840,615887) PREDICTED: s (316 aa)
initn: 305 init1: 209 opt: 275 Z-score: 334.3 bits: 70.9 E(85289): 7e-12
Smith-Waterman score: 275; 27.6% identity (59.0% similar) in 239 aa overlap (342-578:73-303)
320 330 340 350 360 370
pF1KE6 LDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNCLHLVISPLVVV
::: .:. .:: .. : :
XP_011 NERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVE
50 60 70 80 90 100
380 390 400 410 420 430
pF1KE6 LTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWLFAFLGFLTSAL
. : ..: : : :: . : . . . . :: . .: .. :.:..:
XP_011 ADFLS-PFSVPEARGDKVKWVFTW----PLIFLLCVTIPNCSKPRWEKFF-MVTFITATL
110 120 130 140 150
440 450 460 470 480 490
pF1KE6 WINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSAC
:: . . .: .. .: .. . ....:.:.:: :.:. : .... .:::: :: :
XP_011 WIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNT
160 170 180 190 200 210
500 510 520 530 540
pF1KE6 FGGIIFNILVGVGL--GCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVFSLVSVPLQC
.:. .:.::::.:. : .. . ::.. :: :. .. :: :........ :.
XP_011 IGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGL-VYSVVLLLG-SVALTVLGIHLNK
220 230 240 250 260 270
550 560 570 580
pF1KE6 FQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM
..:.: : .:..: :: ... ::.:
XP_011 WRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLPMCREDD
280 290 300 310
>>XP_011534744 (OMIM: 210750,609840,615887) PREDICTED: s (316 aa)
initn: 305 init1: 209 opt: 275 Z-score: 334.3 bits: 70.9 E(85289): 7e-12
Smith-Waterman score: 275; 27.6% identity (59.0% similar) in 239 aa overlap (342-578:73-303)
320 330 340 350 360 370
pF1KE6 LDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNCLHLVISPLVVV
::: .:. .:: .. : :
XP_011 NERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVE
50 60 70 80 90 100
380 390 400 410 420 430
pF1KE6 LTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWLFAFLGFLTSAL
. : ..: : : :: . : . . . . :: . .: .. :.:..:
XP_011 ADFLS-PFSVPEARGDKVKWVFTW----PLIFLLCVTIPNCSKPRWEKFF-MVTFITATL
110 120 130 140 150
440 450 460 470 480 490
pF1KE6 WINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSAC
:: . . .: .. .: .. . ....:.:.:: :.:. : .... .:::: :: :
XP_011 WIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNT
160 170 180 190 200 210
500 510 520 530 540
pF1KE6 FGGIIFNILVGVGL--GCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVFSLVSVPLQC
.:. .:.::::.:. : .. . ::.. :: :. .. :: :........ :.
XP_011 IGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGL-VYSVVLLLG-SVALTVLGIHLNK
220 230 240 250 260 270
550 560 570 580
pF1KE6 FQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM
..:.: : .:..: :: ... ::.:
XP_011 WRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLPMCREDD
280 290 300 310
>>XP_011534742 (OMIM: 210750,609840,615887) PREDICTED: s (372 aa)
initn: 305 init1: 209 opt: 275 Z-score: 333.3 bits: 71.0 E(85289): 8e-12
Smith-Waterman score: 275; 27.6% identity (59.0% similar) in 239 aa overlap (342-578:129-359)
320 330 340 350 360 370
pF1KE6 LDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNCLHLVISPLVVV
::: .:. .:: .. : :
XP_011 NERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPPPPEPEPVE
100 110 120 130 140 150
380 390 400 410 420 430
pF1KE6 LTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWLFAFLGFLTSAL
. : ..: : : :: . : . . . . :: . .: .. :.:..:
XP_011 ADFLS-PFSVPEARGDKVKWVFTW----PLIFLLCVTIPNCSKPRWEKFF-MVTFITATL
160 170 180 190 200 210
440 450 460 470 480 490
pF1KE6 WINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLARQGYPRMAFSAC
:: . . .: .. .: .. . ....:.:.:: :.:. : .... .:::: :: :
XP_011 WIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVSNT
220 230 240 250 260 270
500 510 520 530 540
pF1KE6 FGGIIFNILVGVGL--GCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVFSLVSVPLQC
.:. .:.::::.:. : .. . ::.. :: :. .. :: :........ :.
XP_011 IGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGL-VYSVVLLLG-SVALTVLGIHLNK
280 290 300 310 320 330
550 560 570 580
pF1KE6 FQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM
..:.: : .:..: :: ... ::.:
XP_011 WRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLPMCREDD
340 350 360 370
584 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 13:46:30 2016 done: Tue Nov 8 13:46:32 2016
Total Scan time: 9.260 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]