Result of FASTA (omim) for
pFN21AE6483
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6483, 553 aa
1>>>pF1KE6483 553 - 553 aa - 553 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5971+/-0.000374; mu= 17.2675+/- 0.023
mean_var=72.2311+/-15.206, 0's: 0 Z-trim(113.8): 194 B-trim: 1361 in 1/48
Lambda= 0.150908
statistics sampled from 23161 (23360) to 23161 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.642), E-opt: 0.2 (0.274), width: 16
Scan time: 9.090
The best scores are: opt bits E(85289)
NP_653186 (OMIM: 220150,607096) solute carrier fam ( 553) 3692 813.3 0
NP_001263255 (OMIM: 220150,607096) solute carrier ( 519) 2204 489.3 1.2e-137
NP_700357 (OMIM: 220150,607096) solute carrier fam ( 332) 2185 485.1 1.5e-136
XP_006718494 (OMIM: 220150,607096) PREDICTED: solu ( 543) 2186 485.4 2e-136
XP_006718493 (OMIM: 220150,607096) PREDICTED: solu ( 578) 2186 485.4 2.1e-136
NP_060954 (OMIM: 607097) solute carrier family 22 ( 550) 1920 427.5 5.4e-119
NP_001263256 (OMIM: 220150,607096) solute carrier ( 445) 1801 401.5 2.8e-111
NP_001034841 (OMIM: 607580) solute carrier family ( 541) 1744 389.2 1.8e-107
XP_011543318 (OMIM: 607580) PREDICTED: solute carr ( 541) 1744 389.2 1.8e-107
NP_001129978 (OMIM: 611698) solute carrier family ( 552) 1641 366.7 1e-100
NP_955384 (OMIM: 610792) solute carrier family 22 ( 547) 1591 355.8 2e-97
XP_016873176 (OMIM: 610792) PREDICTED: solute carr ( 547) 1591 355.8 2e-97
NP_543142 (OMIM: 607579) solute carrier family 22 ( 553) 1541 345.0 3.7e-94
XP_016873188 (OMIM: 607580) PREDICTED: solute carr ( 489) 1540 344.7 3.9e-94
NP_695008 (OMIM: 607582) solute carrier family 22 ( 550) 1476 330.8 6.8e-90
NP_004781 (OMIM: 607582) solute carrier family 22 ( 563) 1473 330.2 1.1e-89
XP_016874051 (OMIM: 607582) PREDICTED: solute carr ( 551) 1464 328.2 4.1e-89
NP_001294914 (OMIM: 607097) solute carrier family ( 442) 1372 308.1 3.7e-83
NP_004245 (OMIM: 607581) solute carrier family 22 ( 542) 1356 304.7 4.9e-82
NP_001171661 (OMIM: 607581) solute carrier family ( 542) 1356 304.7 4.9e-82
XP_016873190 (OMIM: 607580) PREDICTED: solute carr ( 424) 1292 290.7 6.2e-78
NP_001171662 (OMIM: 607581) solute carrier family ( 451) 1283 288.7 2.5e-77
NP_695009 (OMIM: 607582) solute carrier family 22 ( 506) 1268 285.5 2.7e-76
NP_695010 (OMIM: 607582) solute carrier family 22 ( 519) 1268 285.5 2.8e-76
XP_016872648 (OMIM: 607579) PREDICTED: solute carr ( 445) 1254 282.4 2e-75
XP_016873191 (OMIM: 607580) PREDICTED: solute carr ( 365) 1211 273.0 1.1e-72
XP_011543666 (OMIM: 607581) PREDICTED: solute carr ( 419) 1151 260.0 1.1e-68
NP_001171665 (OMIM: 607581) solute carrier family ( 419) 1151 260.0 1.1e-68
XP_011543469 (OMIM: 607097) PREDICTED: solute carr ( 417) 1150 259.8 1.2e-68
NP_006663 (OMIM: 604995) solute carrier family 22 ( 546) 1090 246.8 1.3e-64
XP_006715034 (OMIM: 604995) PREDICTED: solute carr ( 549) 1086 245.9 2.4e-64
NP_696961 (OMIM: 604995) solute carrier family 22 ( 548) 1078 244.2 8.2e-64
XP_006715033 (OMIM: 604995) PREDICTED: solute carr ( 551) 1070 242.4 2.7e-63
NP_004247 (OMIM: 604047) solute carrier family 22 ( 551) 1052 238.5 4.2e-62
XP_016873180 (OMIM: 610792) PREDICTED: solute carr ( 452) 994 225.8 2.2e-58
XP_016873179 (OMIM: 610792) PREDICTED: solute carr ( 452) 994 225.8 2.2e-58
XP_016873178 (OMIM: 610792) PREDICTED: solute carr ( 466) 994 225.8 2.3e-58
XP_016873177 (OMIM: 610792) PREDICTED: solute carr ( 477) 994 225.8 2.3e-58
XP_016873174 (OMIM: 610792) PREDICTED: solute carr ( 577) 985 223.9 1.1e-57
XP_016873173 (OMIM: 610792) PREDICTED: solute carr ( 577) 985 223.9 1.1e-57
XP_016873175 (OMIM: 610792) PREDICTED: solute carr ( 577) 985 223.9 1.1e-57
XP_016873183 (OMIM: 610792) PREDICTED: solute carr ( 379) 980 222.7 1.6e-57
XP_016873182 (OMIM: 610792) PREDICTED: solute carr ( 381) 980 222.7 1.6e-57
XP_016873181 (OMIM: 610792) PREDICTED: solute carr ( 405) 980 222.8 1.7e-57
NP_775857 (OMIM: 611698) solute carrier family 22 ( 322) 932 212.3 1.9e-54
XP_016873192 (OMIM: 607580) PREDICTED: solute carr ( 331) 907 206.8 8.6e-53
XP_016865689 (OMIM: 604995) PREDICTED: solute carr ( 543) 906 206.7 1.5e-52
XP_011512558 (OMIM: 604995) PREDICTED: solute carr ( 610) 900 205.4 4.1e-52
XP_016865687 (OMIM: 604995) PREDICTED: solute carr ( 602) 899 205.2 4.8e-52
NP_003051 (OMIM: 212140,603377) solute carrier fam ( 557) 898 205.0 5.2e-52
>>NP_653186 (OMIM: 220150,607096) solute carrier family (553 aa)
initn: 3692 init1: 3692 opt: 3692 Z-score: 4342.3 bits: 813.3 E(85289): 0
Smith-Waterman score: 3692; 100.0% identity (100.0% similar) in 553 aa overlap (1-553:1-553)
10 20 30 40 50 60
pF1KE6 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_653 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH
490 500 510 520 530 540
550
pF1KE6 GTLGNSVLKSTQF
:::::::::::::
NP_653 GTLGNSVLKSTQF
550
>>NP_001263255 (OMIM: 220150,607096) solute carrier fami (519 aa)
initn: 2194 init1: 2194 opt: 2204 Z-score: 2591.9 bits: 489.3 E(85289): 1.2e-137
Smith-Waterman score: 3387; 93.7% identity (93.9% similar) in 553 aa overlap (1-553:1-519)
10 20 30 40 50 60
pF1KE6 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG
:::::: .:::::::::::::::::::
NP_001 LQMAVM----------------------------------VMEWTAARARPLVMTLNSLG
190 200
250 260 270 280 290 300
pF1KE6 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW
210 220 230 240 250 260
310 320 330 340 350 360
pF1KE6 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF
270 280 290 300 310 320
370 380 390 400 410 420
pF1KE6 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI
330 340 350 360 370 380
430 440 450 460 470 480
pF1KE6 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA
390 400 410 420 430 440
490 500 510 520 530 540
pF1KE6 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH
450 460 470 480 490 500
550
pF1KE6 GTLGNSVLKSTQF
:::::::::::::
NP_001 GTLGNSVLKSTQF
510
>>NP_700357 (OMIM: 220150,607096) solute carrier family (332 aa)
initn: 2185 init1: 2185 opt: 2185 Z-score: 2572.5 bits: 485.1 E(85289): 1.5e-136
Smith-Waterman score: 2185; 100.0% identity (100.0% similar) in 332 aa overlap (222-553:1-332)
200 210 220 230 240 250
pF1KE6 FAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLGFSFGHGLTAAV
::::::::::::::::::::::::::::::
NP_700 MEWTAARARPLVMTLNSLGFSFGHGLTAAV
10 20 30
260 270 280 290 300 310
pF1KE6 AYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_700 AYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAV
40 50 60 70 80 90
320 330 340 350 360 370
pF1KE6 QDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_700 QDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDL
100 110 120 130 140 150
380 390 400 410 420 430
pF1KE6 QALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_700 QALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMG
160 170 180 190 200 210
440 450 460 470 480 490
pF1KE6 ALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_700 ALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGV
220 230 240 250 260 270
500 510 520 530 540 550
pF1KE6 HGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_700 HGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKST
280 290 300 310 320 330
pF1KE6 QF
::
NP_700 QF
>>XP_006718494 (OMIM: 220150,607096) PREDICTED: solute c (543 aa)
initn: 3446 init1: 2186 opt: 2186 Z-score: 2570.4 bits: 485.4 E(85289): 2e-136
Smith-Waterman score: 3400; 95.2% identity (95.4% similar) in 543 aa overlap (36-553:1-543)
10 20 30 40 50 60
pF1KE6 LLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQASILG
::::::::::::::::::::::::::::::
XP_006 MLENFSAAVPSHRCWAPLLDNSTAQASILG
10 20 30
70 80 90 100 110 120
pF1KE6 SLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGWVYDRS
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE6 IFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSYLQMAV
100 110 120 130 140 150
190 200 210 220
pF1KE6 MGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTL-------------------------
:::::::::::::::::::::::::::::::::::
XP_006 MGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLRRSLTWRHAGGLHAGSRAEPLGLLA
160 170 180 190 200 210
230 240 250 260 270 280
pF1KE6 LMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLA
.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLA
220 230 240 250 260 270
290 300 310 320 330 340
pF1KE6 ESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTL
280 290 300 310 320 330
350 360 370 380 390 400
pF1KE6 LRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLL
340 350 360 370 380 390
410 420 430 440 450 460
pF1KE6 SHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELF
400 410 420 430 440 450
470 480 490 500 510 520
pF1KE6 PTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQS
460 470 480 490 500 510
530 540 550
pF1KE6 LPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
:::::::::::::::::::::::::::::::::
XP_006 LPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
520 530 540
>>XP_006718493 (OMIM: 220150,607096) PREDICTED: solute c (578 aa)
initn: 3674 init1: 2186 opt: 2186 Z-score: 2570.0 bits: 485.4 E(85289): 2.1e-136
Smith-Waterman score: 3628; 95.5% identity (95.7% similar) in 578 aa overlap (1-553:1-578)
10 20 30 40 50 60
pF1KE6 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY
130 140 150 160 170 180
190 200 210 220
pF1KE6 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTL--------------------
::::::::::::::::::::::::::::::::::::::::
XP_006 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLRRSLTWRHAGGLHAGSRAEP
190 200 210 220 230 240
230 240 250 260 270
pF1KE6 -----LMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLY
.::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LGLLAVMEWTAARARPLVMTLNSLGFSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLY
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE6 SWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SWWLAESARWLLTTGRLDWGLQELWRVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPA
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE6 SLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SLGTLLRMPGLRFRTCISTLCWFAFGFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMG
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE6 ALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ALLLLSHLGRRPTLAASLLLAGLCILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIY
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE6 SSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SSELFPTVLRMTAVGLGQMAARGGAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLL
490 500 510 520 530 540
520 530 540 550
pF1KE6 PETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
::::::::::::::::::::::::::::::::::::::
XP_006 PETQSLPLPDTIQDVQNQAVKKATHGTLGNSVLKSTQF
550 560 570
>>NP_060954 (OMIM: 607097) solute carrier family 22 memb (550 aa)
initn: 1837 init1: 1084 opt: 1920 Z-score: 2257.3 bits: 427.5 E(85289): 5.4e-119
Smith-Waterman score: 1920; 52.1% identity (80.5% similar) in 555 aa overlap (1-553:1-550)
10 20 30 40 50 60
pF1KE6 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ
::::.::. .::.: ::.::...... . . .: .:::::::.:.::::. .:::..:
NP_060 MAFSKLLEQAGGVGLFQTLQVLTFILPCLMIPSQMLLENFSAAIPGHRCWTHMLDNGSAV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW
.. ...:.:::.::::::::: ::::::::::::::::::::::::::::::::::::
NP_060 ST---NMTPKALLTISIPPGPNQGPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW
70 80 90 100 110
130 140 150 160 170 180
pF1KE6 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY
:::::.:::::::::.:::.:..:::..:::...:::::. : : ::::. .:.:
NP_060 VYDRSVFTSTIVAKWDLVCSSQGLKPLSQSIFMSGILVGSFIWGLLSYRFGRKPMLSWCC
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE6 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG
::.:: ::.. :::.: .:: .::. ::..::..... ::..:::.. : ..::. . .
NP_060 LQLAVAGTSTIFAPTFVIYCGLRFVAAFGMAGIFLSSLTLMVEWTTTSRRAVTMTVVGCA
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE6 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW
:: :.. ...:...::: :::..::::: : :::: ::::::. :. : .::::
NP_060 FSAGQAALGGLAFALRDWRTLQLAASVPFFAISLISWWLPESARWLIIKGKPDQALQELR
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE6 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF
.:: :::. ... :: :::.:...::.. .. : :. :. .: ::.:.: . :..
NP_060 KVARINGHKEAKN-LTIEVLMSSVKEEVASAKEPRSVLDLFCVPVLRWRSCAMLVVNFSL
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE6 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI
....::..:::.:: .::::: ..:.::. .. . :::: :::: :.: .::: :
NP_060 LISYYGLVFDLQSLGRDIFLLQALFGAVDFLGRATTALLLSFLGRRTIQAGSQAMAGLAI
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE6 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA
::: :::... .:: ..:::: : : ..::.:::..::::: .:::: :. . ..: ::
NP_060 LANMLVPQDLQTLRVVFAVLGKGCFGISLTCLTIYKAELFPTPVRMTADGILHTVGRLGA
420 430 440 450 460 470
490 500 510 520 530
pF1KE6 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALL-LPETQSLPLPDTIQDVQNQAVKKAT
..:::. . : :: :.::.. . :.:..:. :::::.:::::::::...: . :.
NP_060 MMGPLILMSRQALPLLPPLLYGVISIASSLVVLFFLPETQGLPLPDTIQDLESQK-STAA
480 490 500 510 520 530
540 550
pF1KE6 HGTLGNSV-LKSTQF
.:. ..: ..::..
NP_060 QGNRQEAVTVESTSL
540 550
>>NP_001263256 (OMIM: 220150,607096) solute carrier fami (445 aa)
initn: 1801 init1: 1801 opt: 1801 Z-score: 2118.7 bits: 401.5 E(85289): 2.8e-111
Smith-Waterman score: 2740; 80.5% identity (80.5% similar) in 553 aa overlap (1-553:1-445)
10 20 30 40 50 60
pF1KE6 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDR-----------
130 140 150 160
190 200 210 220 230 240
pF1KE6 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG
NP_001 ------------------------------------------------------------
250 260 270 280 290 300
pF1KE6 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW
:::::::::::::::::::::::
NP_001 -------------------------------------WLAESARWLLTTGRLDWGLQELW
170 180 190
310 320 330 340 350 360
pF1KE6 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF
200 210 220 230 240 250
370 380 390 400 410 420
pF1KE6 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI
260 270 280 290 300 310
430 440 450 460 470 480
pF1KE6 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA
320 330 340 350 360 370
490 500 510 520 530 540
pF1KE6 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH
380 390 400 410 420 430
550
pF1KE6 GTLGNSVLKSTQF
:::::::::::::
NP_001 GTLGNSVLKSTQF
440
>>NP_001034841 (OMIM: 607580) solute carrier family 22 m (541 aa)
initn: 1744 init1: 1744 opt: 1744 Z-score: 2050.4 bits: 389.2 E(85289): 1.8e-107
Smith-Waterman score: 1744; 50.3% identity (75.2% similar) in 533 aa overlap (1-533:1-533)
10 20 30 40 50 60
pF1KE6 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ
::: :::. ::::::::.:. . .. :.: : . .::::.::.:.::::. .:::.:..
NP_001 MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW
.. : :: .::: :::: : ::..:::: .:::::: :.: : ::::::::::::
NP_001 GNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY
:::.: : ::::.::.:::: ..:: ..: . :.:.:::. : .:::::::..: :
NP_001 VYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG
::.:. : :::::.:::::..::: .:. .. :.. . :: .. ::. :.: .
NP_001 LQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW
.:.:. . ...:: ::: :..:.:::::. :: : ::.::::::. :..:: ::. :
NP_001 LSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF
.:: :: ...::. ::. :.:.:::. .: ... :.: :..: : :: .. ::
NP_001 KVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFAN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI
. :.: ..:: .::::::::.. :.: . .. ::: :.:.::: . ..:.:: :
NP_001 TIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA
::::.::.:: .:: ::: ::.: .:.:. .... ::.::::: : :. :.: ::
NP_001 LANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH
:.::. : : :: ..:: :...:: ..:::::..:::::::.::.::
NP_001 ALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQKKNLKEK
490 500 510 520 530 540
550
pF1KE6 GTLGNSVLKSTQF
NP_001 A
>>XP_011543318 (OMIM: 607580) PREDICTED: solute carrier (541 aa)
initn: 1744 init1: 1744 opt: 1744 Z-score: 2050.4 bits: 389.2 E(85289): 1.8e-107
Smith-Waterman score: 1744; 50.3% identity (75.2% similar) in 533 aa overlap (1-533:1-533)
10 20 30 40 50 60
pF1KE6 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ
::: :::. ::::::::.:. . .. :.: : . .::::.::.:.::::. .:::.:..
XP_011 MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW
.. : :: .::: :::: : ::..:::: .:::::: :.: : ::::::::::::
XP_011 GNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY
:::.: : ::::.::.:::: ..:: ..: . :.:.:::. : .:::::::..: :
XP_011 VYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG
::.:. : :::::.:::::..::: .:. .. :.. . :: .. ::. :.: .
XP_011 LQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW
.:.:. . ...:: ::: :..:.:::::. :: : ::.::::::. :..:: ::. :
XP_011 LSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF
.:: :: ...::. ::. :.:.:::. .: ... :.: :..: : :: .. ::
XP_011 KVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFAN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 GFTFFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGLCI
. :.: ..:: .::::::::.. :.: . .. ::: :.:.::: . ..:.:: :
XP_011 TIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 LANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARGGA
::::.::.:: .:: ::: ::.: .:.:. .... ::.::::: : :. :.: ::
XP_011 LANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 ILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKATH
:.::. : : :: ..:: :...:: ..:::::..:::::::.::.::
XP_011 ALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQKKNLKEK
490 500 510 520 530 540
550
pF1KE6 GTLGNSVLKSTQF
XP_011 A
>>NP_001129978 (OMIM: 611698) solute carrier family 22 m (552 aa)
initn: 1613 init1: 1613 opt: 1641 Z-score: 1929.0 bits: 366.7 E(85289): 1e-100
Smith-Waterman score: 1641; 46.1% identity (74.6% similar) in 555 aa overlap (1-553:1-552)
10 20 30 40 50 60
pF1KE6 MAFSELLDLVGGLGRFQVLQTMALMVSIMWLCTQSMLENFSAAVPSHRCWAPLLDNSTAQ
:.:. ::: :::.::::. . .. . : . .::::.: .::::::.:::::.:..
NP_001 MGFDVLLDQVGGMGRFQICLIAFFCITNILLFPNIVLENFTAFTPSHRCWVPLLDNDTVS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ASILGSLSPEALLAISIPPGPNQRPHQCRRFRQPQWQLLDPNATATSWSEADTEPCVDGW
. :.:: . :: :::: : ::..:.:: .:::::: :.: . .: :::::::::
NP_001 DNDTGTLSKDDLLRISIPLDSNLRPQKCQRFIHPQWQLLHLNGTFPNTNEPDTEPCVDGW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 VYDRSIFTSTIVAKWNLVCDSHALKPMAQSIYLAGILVGAAACGPASDRFGRRLVLTWSY
::::: : ::::..:.:::.:..:: :.::...:: :.:. : ::: ::... .
NP_001 VYDRSSFLSTIVTEWDLVCESQSLKSMVQSLFMAGSLLGGLIYGHLSDRVGRKIICKLCF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 LQMAVMGTAAAFAPAFPVYCLFRFLLAFAVAGVMMNTGTLLMEWTAARARPLVMTLNSLG
::.:. .: :::::.: :::..::: .:.. .. :: : .::: :.: ... . .
NP_001 LQLAISNTCAAFAPTFLVYCILRFLAGFSTMTILGNTFILSLEWTLPRSRSMTIMVLLCS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 FSFGHGLTAAVAYGVRDWTLLQLVVSVPFFLCFLYSWWLAESARWLLTTGRLDWGLQELW
.: :. : ...:....:: .:::.::.:... :: :: ..::::::. ...:: ::.::
NP_001 YSVGQMLLGGLAFAIQDWHILQLTVSTPIIVLFLSSWKMVESARWLIINNQLDEGLKELR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 RVAAINGKGAVQDTLTPEVLLSAMREELSMGQPPASLGTLLRMPGLRFRTCISTLCWFAF
::: :::: ...::: :.. :.:..::. . .:. .:.: : ::.: . ::. :
NP_001 RVAHINGKKNTEETLTTELVRSTMKKELDAVRIKTSIFSLFRAPKLRMR--VFGLCFVRF
310 320 330 340 350
370 380 390 400 410
pF1KE6 GFT--FFGLALDLQALGSNIFLLQMFIGVVDIPAKMGALLLLSHLGRRPTLAASLLLAGL
..: :.:: :.:: ::::. :.:.. :.: . :. .:: :.:.::: . . .::
NP_001 AITVPFYGLILNLQHLGSNVSLFQILCGAVTFTARCVSLLTLNHMGRRISQILFTFPVGL
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE6 CILANTLVPHEMGALRSALAVLGLGGVGAAFTCITIYSSELFPTVLRMTAVGLGQMAARG
::.::..:.:: :: .::.::.:.:.:: . ... .:: ::.:: :..:.. ...:
NP_001 FILVNTFLPQEMQILRVVLATLGIGSVSAASNSASVHHNELVPTILRSTVAGINAVSGRT
420 430 440 450 460 470
480 490 500 510 520 530
pF1KE6 GAILGPLVRLLGVHGPWLPLLVYGTVPVLSGLAALLLPETQSLPLPDTIQDVQNQAVKKA
:: :.::. : ...: :: . ::. :.:. . ::::::..::::.:::::.:. : .
NP_001 GAALAPLLMTLMAYSPHLPWISYGVFPILAVPVILLLPETRDLPLPNTIQDVENDR-KDS
480 490 500 510 520 530
540 550
pF1KE6 THGTLGNSVLKSTQF
. .. .: :::
NP_001 RNIKQEDTCMKVTQF
540 550
553 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 13:44:22 2016 done: Tue Nov 8 13:44:23 2016
Total Scan time: 9.090 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]