Result of FASTA (omim) for
pFN21AE6463
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6463, 500 aa
1>>>pF1KE6463 500 - 500 aa - 500 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9259+/-0.000418; mu= 20.1799+/- 0.026
mean_var=61.3032+/-12.697, 0's: 0 Z-trim(110.6): 97 B-trim: 549 in 2/48
Lambda= 0.163807
statistics sampled from 18820 (18975) to 18820 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.583), E-opt: 0.2 (0.222), width: 16
Scan time: 7.490
The best scores are: opt bits E(85289)
NP_995322 (OMIM: 113750,609802) sodium/potassium/c ( 500) 3315 792.3 0
XP_016877568 (OMIM: 113750,609802) PREDICTED: sodi ( 314) 1789 431.6 1.6e-120
XP_016877569 (OMIM: 113750,609802) PREDICTED: sodi ( 314) 1789 431.6 1.6e-120
XP_011534743 (OMIM: 210750,609840,615887) PREDICTE ( 316) 684 170.4 6.6e-42
XP_011534744 (OMIM: 210750,609840,615887) PREDICTE ( 316) 684 170.4 6.6e-42
XP_011534742 (OMIM: 210750,609840,615887) PREDICTE ( 372) 684 170.5 7.5e-42
NP_065740 (OMIM: 609839) sodium/potassium/calcium ( 644) 631 158.1 6.9e-38
NP_705934 (OMIM: 210750,609840,615887) sodium/pota ( 558) 616 154.5 7.2e-37
NP_705932 (OMIM: 210750,609840,615887) sodium/pota ( 622) 616 154.6 7.8e-37
XP_011534740 (OMIM: 210750,609840,615887) PREDICTE ( 645) 616 154.6 8.1e-37
XP_011534738 (OMIM: 210750,609840,615887) PREDICTE ( 669) 616 154.6 8.3e-37
NP_705933 (OMIM: 210750,609840,615887) sodium/pota ( 603) 609 152.9 2.4e-36
XP_011534741 (OMIM: 210750,609840,615887) PREDICTE ( 626) 609 152.9 2.5e-36
XP_011534739 (OMIM: 210750,609840,615887) PREDICTE ( 650) 609 152.9 2.6e-36
NP_001180217 (OMIM: 609838) sodium/potassium/calci ( 644) 593 149.1 3.5e-35
XP_016870082 (OMIM: 609838) PREDICTED: sodium/pota ( 644) 593 149.1 3.5e-35
XP_006716813 (OMIM: 609838) PREDICTED: sodium/pota ( 644) 593 149.1 3.5e-35
XP_005251482 (OMIM: 609838) PREDICTED: sodium/pota ( 661) 593 149.1 3.6e-35
XP_005251483 (OMIM: 609838) PREDICTED: sodium/pota ( 661) 593 149.1 3.6e-35
NP_065077 (OMIM: 609838) sodium/potassium/calcium ( 661) 593 149.1 3.6e-35
XP_016870081 (OMIM: 609838) PREDICTED: sodium/pota ( 661) 593 149.1 3.6e-35
XP_006720831 (OMIM: 603617,613830) PREDICTED: sodi ( 985) 568 143.3 3e-33
XP_011520528 (OMIM: 603617,613830) PREDICTED: sodi ( 688) 564 142.3 4.3e-33
XP_005254838 (OMIM: 603617,613830) PREDICTED: sodi ( 717) 564 142.3 4.4e-33
NP_001287962 (OMIM: 603617,613830) sodium/potassiu (1012) 565 142.6 4.9e-33
XP_011520522 (OMIM: 603617,613830) PREDICTED: sodi (1081) 565 142.7 5.2e-33
NP_001287961 (OMIM: 603617,613830) sodium/potassiu (1081) 565 142.7 5.2e-33
XP_016878214 (OMIM: 603617,613830) PREDICTED: sodi ( 966) 564 142.4 5.6e-33
XP_011520524 (OMIM: 603617,613830) PREDICTED: sodi (1030) 564 142.4 5.9e-33
XP_016878213 (OMIM: 603617,613830) PREDICTED: sodi (1049) 564 142.4 6e-33
NP_001287960 (OMIM: 603617,613830) sodium/potassiu (1069) 564 142.4 6.1e-33
XP_011520523 (OMIM: 603617,613830) PREDICTED: sodi (1069) 564 142.4 6.1e-33
XP_011520521 (OMIM: 603617,613830) PREDICTED: sodi (1099) 564 142.4 6.2e-33
XP_005254835 (OMIM: 603617,613830) PREDICTED: sodi (1099) 564 142.4 6.2e-33
NP_004718 (OMIM: 603617,613830) sodium/potassium/c (1099) 564 142.4 6.2e-33
NP_001241669 (OMIM: 603617,613830) sodium/potassiu ( 426) 533 134.8 4.6e-31
NP_001317395 (OMIM: 609841) sodium/potassium/calci ( 528) 309 82.0 4.8e-15
XP_005267399 (OMIM: 210750,609840,615887) PREDICTE ( 352) 285 76.2 1.7e-13
XP_006719670 (OMIM: 609841) PREDICTED: sodium/pota ( 389) 251 68.2 5e-11
XP_011537054 (OMIM: 609841) PREDICTED: sodium/pota ( 389) 251 68.2 5e-11
NP_079235 (OMIM: 609841) sodium/potassium/calcium ( 584) 251 68.3 6.9e-11
XP_011537051 (OMIM: 609841) PREDICTED: sodium/pota ( 584) 251 68.3 6.9e-11
XP_016875467 (OMIM: 609841) PREDICTED: sodium/pota ( 422) 218 60.4 1.2e-08
XP_005264571 (OMIM: 182305) PREDICTED: sodium/calc ( 937) 177 50.9 1.9e-05
NP_001106273 (OMIM: 182305) sodium/calcium exchang ( 937) 177 50.9 1.9e-05
XP_016860252 (OMIM: 182305) PREDICTED: sodium/calc ( 938) 177 50.9 1.9e-05
XP_016860251 (OMIM: 182305) PREDICTED: sodium/calc ( 938) 177 50.9 1.9e-05
XP_016860249 (OMIM: 182305) PREDICTED: sodium/calc ( 945) 177 50.9 1.9e-05
XP_016860250 (OMIM: 182305) PREDICTED: sodium/calc ( 945) 177 50.9 1.9e-05
XP_016860248 (OMIM: 182305) PREDICTED: sodium/calc ( 945) 177 50.9 1.9e-05
>>NP_995322 (OMIM: 113750,609802) sodium/potassium/calci (500 aa)
initn: 3315 init1: 3315 opt: 3315 Z-score: 4230.8 bits: 792.3 E(85289): 0
Smith-Waterman score: 3315; 100.0% identity (100.0% similar) in 500 aa overlap (1-500:1-500)
10 20 30 40 50 60
pF1KE6 MQTKGGQTWARRALLLGILWATAHLPLSGTSLPQRLPRATGNSTQCVISPSSEFPEGFFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_995 MQTKGGQTWARRALLLGILWATAHLPLSGTSLPQRLPRATGNSTQCVISPSSEFPEGFFT
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 RQERRDGGIIIYFLIIVYMFMAISIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_995 RQERRDGGIIIYFLIIVYMFMAISIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 PELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPLFRDCAAYT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_995 PELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPLFRDCAAYT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 ISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYIIKKCSPCCACLAKAME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_995 ISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYIIKKCSPCCACLAKAME
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 RSEQQPLMGWEDEGQPFIRRQSRTDSGIFYEDSGYSQLSISLHGLSQVSEDPPSVFNMPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_995 RSEQQPLMGWEDEGQPFIRRQSRTDSGIFYEDSGYSQLSISLHGLSQVSEDPPSVFNMPE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 ADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYILVWMVTITG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_995 ADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYILVWMVTITG
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 ETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLCLGIPWFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_995 ETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLCLGIPWFI
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 KTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDRKLGIVCLLSYLGLAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_995 KTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDRKLGIVCLLSYLGLAT
430 440 450 460 470 480
490 500
pF1KE6 LSVLYELGIIGNNKIRGCGG
::::::::::::::::::::
NP_995 LSVLYELGIIGNNKIRGCGG
490 500
>>XP_016877568 (OMIM: 113750,609802) PREDICTED: sodium/p (314 aa)
initn: 1789 init1: 1789 opt: 1789 Z-score: 2284.7 bits: 431.6 E(85289): 1.6e-120
Smith-Waterman score: 1804; 90.1% identity (90.1% similar) in 313 aa overlap (114-395:1-313)
90 100 110 120
pF1KE6 SIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSAPELVTAFLG--------------
::::::::::::::::
XP_016 MAAGSSAPELVTAFLGKYCSLYFLLTQCDF
10 20 30
130 140 150 160 170
pF1KE6 -----------------VFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPL
:::::::::::::::::::::::::::::::::::::::::::
XP_016 YFLQVNTNLAGTILHIGVFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPL
40 50 60 70 80 90
180 190 200 210 220 230
pF1KE6 FRDCAAYTISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYIIKKCSPCC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FRDCAAYTISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYIIKKCSPCC
100 110 120 130 140 150
240 250 260 270 280 290
pF1KE6 ACLAKAMERSEQQPLMGWEDEGQPFIRRQSRTDSGIFYEDSGYSQLSISLHGLSQVSEDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ACLAKAMERSEQQPLMGWEDEGQPFIRRQSRTDSGIFYEDSGYSQLSISLHGLSQVSEDP
160 170 180 190 200 210
300 310 320 330 340 350
pF1KE6 PSVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYIL
220 230 240 250 260 270
360 370 380 390 400 410
pF1KE6 VWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDML
:::::::::::::::::::::::::::::::::::::::::::
XP_016 VWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKN
280 290 300 310
420 430 440 450 460 470
pF1KE6 CLGIPWFIKTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDRKLGIVCL
>>XP_016877569 (OMIM: 113750,609802) PREDICTED: sodium/p (314 aa)
initn: 1789 init1: 1789 opt: 1789 Z-score: 2284.7 bits: 431.6 E(85289): 1.6e-120
Smith-Waterman score: 1804; 90.1% identity (90.1% similar) in 313 aa overlap (114-395:1-313)
90 100 110 120
pF1KE6 SIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSAPELVTAFLG--------------
::::::::::::::::
XP_016 MAAGSSAPELVTAFLGKYCSLYFLLTQCDF
10 20 30
130 140 150 160 170
pF1KE6 -----------------VFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPL
:::::::::::::::::::::::::::::::::::::::::::
XP_016 YFLQVNTNLAGTILHIGVFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPL
40 50 60 70 80 90
180 190 200 210 220 230
pF1KE6 FRDCAAYTISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYIIKKCSPCC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FRDCAAYTISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYIIKKCSPCC
100 110 120 130 140 150
240 250 260 270 280 290
pF1KE6 ACLAKAMERSEQQPLMGWEDEGQPFIRRQSRTDSGIFYEDSGYSQLSISLHGLSQVSEDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ACLAKAMERSEQQPLMGWEDEGQPFIRRQSRTDSGIFYEDSGYSQLSISLHGLSQVSEDP
160 170 180 190 200 210
300 310 320 330 340 350
pF1KE6 PSVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYIL
220 230 240 250 260 270
360 370 380 390 400 410
pF1KE6 VWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDML
:::::::::::::::::::::::::::::::::::::::::::
XP_016 VWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKN
280 290 300 310
420 430 440 450 460 470
pF1KE6 CLGIPWFIKTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDRKLGIVCL
>>XP_011534743 (OMIM: 210750,609840,615887) PREDICTED: s (316 aa)
initn: 653 init1: 472 opt: 684 Z-score: 873.3 bits: 170.4 E(85289): 6.6e-42
Smith-Waterman score: 684; 46.8% identity (77.3% similar) in 203 aa overlap (288-489:101-303)
260 270 280 290 300 310
pF1KE6 IRRQSRTDSGIFYEDSGYSQLSISLHGLSQVSEDPPSVFNMPEADLKRIFWVLSLPIITL
: : : :..::: .. ::.. :.: :
XP_011 GNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFL
80 90 100 110 120 130
320 330 340 350 360 370
pF1KE6 LFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAA
: .: :.: : :...:..::. ...::..:.::.::.::: : :: :::..::.:.:::
XP_011 LCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAA
140 150 160 170 180 190
380 390 400 410 420 430
pF1KE6 GTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLC-LGIPWFIKTAFINGSAPAEVNSR
:::.:: .::..:::.: ::::.:: .::::::.: ::.:: ..: .: .. ...:::
XP_011 GTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSR
200 210 220 230 240 250
440 450 460 470 480 490
pF1KE6 GLTYITISLNISIIFLFLAVHFNGWKLDRKLGIVCLLSYLGLATLSVLYELGIIGNNKIR
::.: .. : :. . :..:.: :.::::::. :. : . .:.. :...
XP_011 GLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLP
260 270 280 290 300 310
500
pF1KE6 GCGG
XP_011 MCREDD
>>XP_011534744 (OMIM: 210750,609840,615887) PREDICTED: s (316 aa)
initn: 653 init1: 472 opt: 684 Z-score: 873.3 bits: 170.4 E(85289): 6.6e-42
Smith-Waterman score: 684; 46.8% identity (77.3% similar) in 203 aa overlap (288-489:101-303)
260 270 280 290 300 310
pF1KE6 IRRQSRTDSGIFYEDSGYSQLSISLHGLSQVSEDPPSVFNMPEADLKRIFWVLSLPIITL
: : : :..::: .. ::.. :.: :
XP_011 GNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFL
80 90 100 110 120 130
320 330 340 350 360 370
pF1KE6 LFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAA
: .: :.: : :...:..::. ...::..:.::.::.::: : :: :::..::.:.:::
XP_011 LCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAA
140 150 160 170 180 190
380 390 400 410 420 430
pF1KE6 GTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLC-LGIPWFIKTAFINGSAPAEVNSR
:::.:: .::..:::.: ::::.:: .::::::.: ::.:: ..: .: .. ...:::
XP_011 GTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSR
200 210 220 230 240 250
440 450 460 470 480 490
pF1KE6 GLTYITISLNISIIFLFLAVHFNGWKLDRKLGIVCLLSYLGLATLSVLYELGIIGNNKIR
::.: .. : :. . :..:.: :.::::::. :. : . .:.. :...
XP_011 GLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLP
260 270 280 290 300 310
500
pF1KE6 GCGG
XP_011 MCREDD
>>XP_011534742 (OMIM: 210750,609840,615887) PREDICTED: s (372 aa)
initn: 653 init1: 472 opt: 684 Z-score: 872.3 bits: 170.5 E(85289): 7.5e-42
Smith-Waterman score: 684; 46.8% identity (77.3% similar) in 203 aa overlap (288-489:157-359)
260 270 280 290 300 310
pF1KE6 IRRQSRTDSGIFYEDSGYSQLSISLHGLSQVSEDPPSVFNMPEADLKRIFWVLSLPIITL
: : : :..::: .. ::.. :.: :
XP_011 GNVPVENPEDPQQNQEQQPPPQPPPPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFL
130 140 150 160 170 180
320 330 340 350 360 370
pF1KE6 LFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAA
: .: :.: : :...:..::. ...::..:.::.::.::: : :: :::..::.:.:::
XP_011 LCVTIPNCSKPRWEKFFMVTFITATLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAA
190 200 210 220 230 240
380 390 400 410 420 430
pF1KE6 GTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLC-LGIPWFIKTAFINGSAPAEVNSR
:::.:: .::..:::.: ::::.:: .::::::.: ::.:: ..: .: .. ...:::
XP_011 GTSVPDCMASLIVARQGLGDMAVSNTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSR
250 260 270 280 290 300
440 450 460 470 480 490
pF1KE6 GLTYITISLNISIIFLFLAVHFNGWKLDRKLGIVCLLSYLGLATLSVLYELGIIGNNKIR
::.: .. : :. . :..:.: :.::::::. :. : . .:.. :...
XP_011 GLVYSVVLLLGSVALTVLGIHLNKWRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLP
310 320 330 340 350 360
500
pF1KE6 GCGG
XP_011 MCREDD
370
>>NP_065740 (OMIM: 609839) sodium/potassium/calcium exch (644 aa)
initn: 1150 init1: 631 opt: 631 Z-score: 801.2 bits: 158.1 E(85289): 6.9e-38
Smith-Waterman score: 958; 36.7% identity (60.8% similar) in 490 aa overlap (42-428:83-572)
20 30 40 50 60 70
pF1KE6 RALLLGILWATAHLPLSGTSLPQRLPRATGNSTQCVISPSSEFPEGFFTRQERRDGGIII
:: .:. :::. .:: ..::.:....
NP_065 DLVGEDRKWMMARKLMQVNDTLTSEDAGLRNSKNCTEPALHEFPNDIFTNEDRRQGAVVL
60 70 80 90 100 110
80 90 100 110 120 130
pF1KE6 YFLIIVYMFMAISIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSAPELVTAFLGVF
. : .:::.:..::::..:.:::: : : : ::.::::.:::::::::::: :. .:::
NP_065 HVLCAIYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSAPELFTSVIGVF
120 130 140 150 160 170
140 150 160 170 180 190
pF1KE6 ITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPLFRDCAAYTISAAAVLGIIY
:::::.:..::.:::..:.: : ..:::... : .:: : :.:: ::.:. :.. .::
NP_065 ITKGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVALSSWCLLRDSIYYTLSVIALIVFIY
180 190 200 210 220 230
200 210 220 230
pF1KE6 DNQVYWYEGALLLLIYGLYVLVL--------CFDIKI-----------NQYIIKKCSPCC
:..: :.:. .:.:.: .:.... ::. . :. : : :
NP_065 DEKVSWWESLVLVLMYLIYIVIMKYNACIHQCFERRTKGAGNMVNGLANNAEIDDSSNCD
240 250 260 270 280 290
240 250 260
pF1KE6 AC---LAKAMERSEQQPLM------------GWEDEGQ--------PFIRRQSRTDSGIF
: : :: . . . .: .. . : : : : .. ..
NP_065 ATVVLLKKANFHRKASVIMVDELLSAYPHQLSFSEAGLRIMITSHFPPKTRLSMASRMLI
300 310 320 330 340 350
270 280
pF1KE6 YE----------DSGYSQLSISL-------HGLSQVS-----------------------
: .: :...:.. .: . :
NP_065 NERQRLINSRAYTNGESEVAIKIPIKHTVENGTGPSSAPDRGVNGTRRDDVVAEAGNETE
360 370 380 390 400 410
290 300 310 320 330
pF1KE6 -------------------EDPPSVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFW
: : . :. : . :. . :... :. .:..:.:.: : :
NP_065 NENEDNENDEEEEEDEDDDEGPYTPFDTPSGKLETVKWAFTWPLSFVLYFTVPNCNKPRW
420 430 440 450 460 470
340 350 360 370 380 390
pF1KE6 KNYFVITFFMSAIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLV
...:..:: :..::.::.:..:::::: : :: :::..::.:.::::::.:: .::..:
NP_065 EKWFMVTFASSTLWIAAFSYMMVWMVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIV
480 490 500 510 520 530
400 410 420 430 440
pF1KE6 ARKGKGDMAMSNIVGSNVFDMLC-LGIPWFIKTAFIN-GSAPAEVNSRGLTYITISLNIS
::.: ::::.:: .::::::.: ::.:: ..: .. ::
NP_065 ARQGMGDMAVSNSIGSNVFDILIGLGLPWALQTLAVDYGSYIRLNSRGLIYSVGLLLASV
540 550 560 570 580 590
450 460 470 480 490 500
pF1KE6 IIFLFLAVHFNGWKLDRKLGIVCLLSYLGLATLSVLYELGIIGNNKIRGCGG
NP_065 FVTVFGVHLNKWQLDKKLGCGCLLLYGVFLCFSIMTEFNVFTFVNLPMCGDH
600 610 620 630 640
>>NP_705934 (OMIM: 210750,609840,615887) sodium/potassiu (558 aa)
initn: 1237 init1: 598 opt: 616 Z-score: 782.9 bits: 154.5 E(85289): 7.2e-37
Smith-Waterman score: 1025; 36.5% identity (64.1% similar) in 493 aa overlap (40-443:7-499)
10 20 30 40 50 60
pF1KE6 ARRALLLGILWATAHLPLSGTSLPQRLPRATGNSTQCVISPSSEFPEGFFTRQERRDGGI
: .. .:. ::: .:. .::. :..
NP_705 MAPVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAV
10 20 30
70 80 90 100 110 120
pF1KE6 IIYFLIIVYMFMAISIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSAPELVTAFLG
....: .:::.:..::::..:.:::: : : : ::.::::.::::::::.::: .. .:
NP_705 LLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIG
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE6 VFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPLFRDCAAYTISAAAVLGI
::::.::.:..::.:::..:.: : ..:::... : :. : . :: . ::::. ... .
NP_705 VFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVF
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE6 IYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYI-IKKCS-----PCCACLAKAMERSE
:::.:. :.:: .:...: .:.:.. ...:.. .. .:. : : . : . . .
NP_705 IYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAFFTVKQKSIANGNPVNSELEAGNDFYD
160 170 180 190 200 210
250 260 270
pF1KE6 QQ------PLMGWEDE----GQ-PFI---RRQSRTDSGIFYEDSGY--------------
. ::.: : :. : . . .: . . . ..:
NP_705 GSYDDPSVPLLGQVKEKPQYGKNPVVMVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRL
220 230 240 250 260 270
280 290
pF1KE6 ---SQLSI--------SLHGLS----------------------------QVSEDPP---
:.. : : .:.: : .. ::
NP_705 RMASRIIINERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPP
280 290 300 310 320 330
300 310 320 330 340
pF1KE6 ------------SVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMS
: :..::: .. ::.. :.: :: .: :.: : :...:..::. .
NP_705 PPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITA
340 350 360 370 380 390
350 360 370 380 390 400
pF1KE6 AIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMS
..::..:.::.::.::: : :: :::..::.:.::::::.:: .::..:::.: ::::.:
NP_705 TLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVS
400 410 420 430 440 450
410 420 430 440 450 460
pF1KE6 NIVGSNVFDMLC-LGIPWFIKTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNG
: .::::::.: ::.:: ..: .: .. ...:::::.: ..
NP_705 NTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNK
460 470 480 490 500 510
470 480 490 500
pF1KE6 WKLDRKLGIVCLLSYLGLATLSVLYELGIIGNNKIRGCGG
NP_705 WRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLPMCREDD
520 530 540 550
>>NP_705932 (OMIM: 210750,609840,615887) sodium/potassiu (622 aa)
initn: 1237 init1: 598 opt: 616 Z-score: 782.2 bits: 154.6 E(85289): 7.8e-37
Smith-Waterman score: 1025; 36.5% identity (64.1% similar) in 493 aa overlap (40-443:71-563)
10 20 30 40 50 60
pF1KE6 ARRALLLGILWATAHLPLSGTSLPQRLPRATGNSTQCVISPSSEFPEGFFTRQERRDGGI
: .. .:. ::: .:. .::. :..
NP_705 GSLGHKTASASKRVLPDTWRNRKLMAPVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAV
50 60 70 80 90 100
70 80 90 100 110 120
pF1KE6 IIYFLIIVYMFMAISIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSAPELVTAFLG
....: .:::.:..::::..:.:::: : : : ::.::::.::::::::.::: .. .:
NP_705 LLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIG
110 120 130 140 150 160
130 140 150 160 170 180
pF1KE6 VFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPLFRDCAAYTISAAAVLGI
::::.::.:..::.:::..:.: : ..:::... : :. : . :: . ::::. ... .
NP_705 VFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVF
170 180 190 200 210 220
190 200 210 220 230 240
pF1KE6 IYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYI-IKKCS-----PCCACLAKAMERSE
:::.:. :.:: .:...: .:.:.. ...:.. .. .:. : : . : . . .
NP_705 IYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAFFTVKQKSIANGNPVNSELEAGNDFYD
230 240 250 260 270 280
250 260 270
pF1KE6 QQ------PLMGWEDE----GQ-PFI---RRQSRTDSGIFYEDSGY--------------
. ::.: : :. : . . .: . . . ..:
NP_705 GSYDDPSVPLLGQVKEKPQYGKNPVVMVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRL
290 300 310 320 330 340
280 290
pF1KE6 ---SQLSI--------SLHGLS----------------------------QVSEDPP---
:.. : : .:.: : .. ::
NP_705 RMASRIIINERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPP
350 360 370 380 390 400
300 310 320 330 340
pF1KE6 ------------SVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMS
: :..::: .. ::.. :.: :: .: :.: : :...:..::. .
NP_705 PPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITA
410 420 430 440 450 460
350 360 370 380 390 400
pF1KE6 AIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMS
..::..:.::.::.::: : :: :::..::.:.::::::.:: .::..:::.: ::::.:
NP_705 TLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVS
470 480 490 500 510 520
410 420 430 440 450 460
pF1KE6 NIVGSNVFDMLC-LGIPWFIKTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNG
: .::::::.: ::.:: ..: .: .. ...:::::.: ..
NP_705 NTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTVLGIHLNK
530 540 550 560 570 580
470 480 490 500
pF1KE6 WKLDRKLGIVCLLSYLGLATLSVLYELGIIGNNKIRGCGG
NP_705 WRLDRKLGVYVLVLYAIFLCFSIMIEFNVFTFVNLPMCREDD
590 600 610 620
>>XP_011534740 (OMIM: 210750,609840,615887) PREDICTED: s (645 aa)
initn: 1177 init1: 598 opt: 616 Z-score: 782.0 bits: 154.6 E(85289): 8.1e-37
Smith-Waterman score: 1025; 36.5% identity (64.1% similar) in 493 aa overlap (40-443:118-610)
10 20 30 40 50 60
pF1KE6 ARRALLLGILWATAHLPLSGTSLPQRLPRATGNSTQCVISPSSEFPEGFFTRQERRDGGI
: .. .:. ::: .:. .::. :..
XP_011 AAAGHKTASASKRVLPDTWRNRKLMAPVNGTQTAKNCTDPAIHEFPTDLFSNKERQHGAV
90 100 110 120 130 140
70 80 90 100 110 120
pF1KE6 IIYFLIIVYMFMAISIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSAPELVTAFLG
....: .:::.:..::::..:.:::: : : : ::.::::.::::::::.::: .. .:
XP_011 LLHILGALYMFYALAIVCDDFFVPSLEKICERLHLSEDVAGATFMAAGSSTPELFASVIG
150 160 170 180 190 200
130 140 150 160 170 180
pF1KE6 VFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPLFRDCAAYTISAAAVLGI
::::.::.:..::.:::..:.: : ..:::... : :. : . :: . ::::. ... .
XP_011 VFITHGDVGVGTIVGSAVFNILCIIGVCGLFAGQVVRLTWWAVCRDSVYYTISVIVLIVF
210 220 230 240 250 260
190 200 210 220 230 240
pF1KE6 IYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYI-IKKCS-----PCCACLAKAMERSE
:::.:. :.:: .:...: .:.:.. ...:.. .. .:. : : . : . . .
XP_011 IYDEQIVWWEGLVLIILYVFYILIMKYNVKMQAFFTVKQKSIANGNPVNSELEAGNDFYD
270 280 290 300 310 320
250 260 270
pF1KE6 QQ------PLMGWEDE----GQ-PFI---RRQSRTDSGIFYEDSGY--------------
. ::.: : :. : . . .: . . . ..:
XP_011 GSYDDPSVPLLGQVKEKPQYGKNPVVMVDEIMSSSPPKFTFPEAGLRIMITNKFGPRTRL
330 340 350 360 370 380
280 290
pF1KE6 ---SQLSI--------SLHGLS----------------------------QVSEDPP---
:.. : : .:.: : .. ::
XP_011 RMASRIIINERQRLINSANGVSSKPLQNGRHENIENGNVPVENPEDPQQNQEQQPPPQPP
390 400 410 420 430 440
300 310 320 330 340
pF1KE6 ------------SVFNMPEADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMS
: :..::: .. ::.. :.: :: .: :.: : :...:..::. .
XP_011 PPEPEPVEADFLSPFSVPEARGDKVKWVFTWPLIFLLCVTIPNCSKPRWEKFFMVTFITA
450 460 470 480 490 500
350 360 370 380 390 400
pF1KE6 AIWISAFTYILVWMVTITGETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMS
..::..:.::.::.::: : :: :::..::.:.::::::.:: .::..:::.: ::::.:
XP_011 TLWIAVFSYIMVWLVTIIGYTLGIPDVIMGITFLAAGTSVPDCMASLIVARQGLGDMAVS
510 520 530 540 550 560
410 420 430 440 450 460
pF1KE6 NIVGSNVFDMLC-LGIPWFIKTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNG
: .::::::.: ::.:: ..: .: .. ...:::::.: ..
XP_011 NTIGSNVFDILVGLGVPWGLQTMVVNYGSTVKINSRGLVYSVVLLLGSVALTCSSEVPGI
570 580 590 600 610 620
470 480 490 500
pF1KE6 WKLDRKLGIVCLLSYLGLATLSVLYELGIIGNNKIRGCGG
XP_011 QPQEALIEGQGGRQWKER
630 640
500 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 13:32:27 2016 done: Tue Nov 8 13:32:29 2016
Total Scan time: 7.490 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]