Result of FASTA (omim) for
pFN21AE6459
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6459, 453 aa
1>>>pF1KE6459 453 - 453 aa - 453 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.1997+/-0.000307; mu= 15.0130+/- 0.019
mean_var=104.1788+/-20.837, 0's: 0 Z-trim(118.9): 42 B-trim: 21 in 1/55
Lambda= 0.125656
statistics sampled from 32318 (32364) to 32318 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.723), E-opt: 0.2 (0.379), width: 16
Scan time: 6.590
The best scores are: opt bits E(85289)
NP_004713 (OMIM: 602296,612936) AP-4 complex subun ( 453) 2996 553.4 4.5e-157
XP_005250746 (OMIM: 602296,612936) PREDICTED: AP-4 ( 460) 2972 549.1 9.2e-156
XP_011514987 (OMIM: 602296,612936) PREDICTED: AP-4 ( 460) 2972 549.1 9.2e-156
XP_006716238 (OMIM: 602296,612936) PREDICTED: AP-4 ( 419) 2441 452.8 8.2e-127
XP_005250747 (OMIM: 602296,612936) PREDICTED: AP-4 ( 385) 2237 415.8 1e-115
XP_016868279 (OMIM: 602296,612936) PREDICTED: AP-4 ( 284) 1628 305.3 1.4e-82
XP_016868280 (OMIM: 602296,612936) PREDICTED: AP-4 ( 228) 1568 294.3 2.2e-79
NP_004059 (OMIM: 601024) AP-2 complex subunit mu i ( 435) 559 111.6 4.3e-24
NP_001020376 (OMIM: 601024) AP-2 complex subunit m ( 433) 515 103.6 1.1e-21
NP_001298127 (OMIM: 601024) AP-2 complex subunit m ( 460) 515 103.6 1.1e-21
NP_001123996 (OMIM: 603535) AP-1 complex subunit m ( 435) 409 84.4 6.5e-16
XP_016882909 (OMIM: 603535) PREDICTED: AP-1 comple ( 409) 371 77.5 7.4e-14
NP_005489 (OMIM: 607309) AP-1 complex subunit mu-2 ( 423) 273 59.8 1.7e-08
NP_001287816 (OMIM: 607309) AP-1 complex subunit m ( 425) 273 59.8 1.7e-08
NP_001307193 (OMIM: 610366) AP-3 complex subunit m ( 418) 271 59.4 2.1e-08
NP_001307192 (OMIM: 610366) AP-3 complex subunit m ( 418) 271 59.4 2.1e-08
NP_036227 (OMIM: 610366) AP-3 complex subunit mu-1 ( 418) 271 59.4 2.1e-08
NP_996895 (OMIM: 610366) AP-3 complex subunit mu-1 ( 418) 271 59.4 2.1e-08
NP_115882 (OMIM: 603535) AP-1 complex subunit mu-1 ( 423) 258 57.0 1.1e-07
XP_016882910 (OMIM: 603535) PREDICTED: AP-1 comple ( 397) 220 50.1 1.3e-05
NP_001307194 (OMIM: 610366) AP-3 complex subunit m ( 364) 182 43.2 0.0014
>>NP_004713 (OMIM: 602296,612936) AP-4 complex subunit m (453 aa)
initn: 2996 init1: 2996 opt: 2996 Z-score: 2941.0 bits: 553.4 E(85289): 4.5e-157
Smith-Waterman score: 2996; 100.0% identity (100.0% similar) in 453 aa overlap (1-453:1-453)
10 20 30 40 50 60
pF1KE6 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVMHHHGRHFIHIR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVMHHHGRHFIHIR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 HSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVLDYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 HSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVLDYG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 YVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRPVLSSRSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 YVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRPVLSSRSD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 QSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEEFCVGKSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 QSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEEFCVGKSE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 LRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSPLPFRLFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSPLPFRLFP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 SVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQKAELAEGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 SVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQKAELAEGA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 LRWDLPRVQGGSQLSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFELPRHTCSGLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 LRWDLPRVQGGSQLSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFELPRHTCSGLQ
370 380 390 400 410 420
430 440 450
pF1KE6 VRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI
:::::::::::::::::::::::::::::::::
NP_004 VRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI
430 440 450
>>XP_005250746 (OMIM: 602296,612936) PREDICTED: AP-4 com (460 aa)
initn: 2668 init1: 2668 opt: 2972 Z-score: 2917.4 bits: 549.1 E(85289): 9.2e-156
Smith-Waterman score: 2972; 98.5% identity (98.5% similar) in 460 aa overlap (1-453:1-460)
10 20 30 40 50
pF1KE6 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVM-------HHHG
::::::::::::::::::::::::::::::::::::::::::::::::: ::::
XP_005 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVMVTSGGRRHHHG
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 RHFIHIRHSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RHFIHIRHSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELL
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE6 DEVLDYGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DEVLDYGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRP
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE6 VLSSRSDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLSSRSDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEE
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE6 FCVGKSELRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FCVGKSELRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSP
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE6 LPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQK
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE6 AELAEGALRWDLPRVQGGSQLSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFELPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AELAEGALRWDLPRVQGGSQLSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFELPR
370 380 390 400 410 420
420 430 440 450
pF1KE6 HTCSGLQVRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI
::::::::::::::::::::::::::::::::::::::::
XP_005 HTCSGLQVRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI
430 440 450 460
>>XP_011514987 (OMIM: 602296,612936) PREDICTED: AP-4 com (460 aa)
initn: 2668 init1: 2668 opt: 2972 Z-score: 2917.4 bits: 549.1 E(85289): 9.2e-156
Smith-Waterman score: 2972; 98.5% identity (98.5% similar) in 460 aa overlap (1-453:1-460)
10 20 30 40 50
pF1KE6 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVM-------HHHG
::::::::::::::::::::::::::::::::::::::::::::::::: ::::
XP_011 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVMVTSGGRRHHHG
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 RHFIHIRHSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RHFIHIRHSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELL
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE6 DEVLDYGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DEVLDYGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRP
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE6 VLSSRSDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLSSRSDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEE
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE6 FCVGKSELRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FCVGKSELRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSP
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE6 LPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQK
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE6 AELAEGALRWDLPRVQGGSQLSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFELPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AELAEGALRWDLPRVQGGSQLSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFELPR
370 380 390 400 410 420
420 430 440 450
pF1KE6 HTCSGLQVRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI
::::::::::::::::::::::::::::::::::::::::
XP_011 HTCSGLQVRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI
430 440 450 460
>>XP_006716238 (OMIM: 602296,612936) PREDICTED: AP-4 com (419 aa)
initn: 2478 init1: 2137 opt: 2441 Z-score: 2397.7 bits: 452.8 E(85289): 8.2e-127
Smith-Waterman score: 2586; 89.6% identity (89.6% similar) in 460 aa overlap (1-453:1-419)
10 20 30 40 50
pF1KE6 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVM-------HHHG
::::::::::::::::::::::::::::::::::::::::::::::::: ::::
XP_006 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVMVTSGGRRHHHG
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 RHFIHIRHSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RHFIHIRHSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELL
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE6 DEVLDYGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DEVLDYGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRP
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE6 VLSSRSDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VLSSRSDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEE
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE6 FCVGKSELRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FCVGKSELRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSP
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE6 LPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQK
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE6 AELAEGALRWDLPRVQGGSQLSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFELPR
::::::::::::::::::::::::::
XP_006 AELAEGALRWDLPRVQGGSQLSGLFQ----------------------------------
370 380
420 430 440 450
pF1KE6 HTCSGLQVRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI
:::::::::::::::::::::::::::::::::
XP_006 -------VRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI
390 400 410
>>XP_005250747 (OMIM: 602296,612936) PREDICTED: AP-4 com (385 aa)
initn: 2237 init1: 2237 opt: 2237 Z-score: 2198.4 bits: 415.8 E(85289): 1e-115
Smith-Waterman score: 2411; 85.0% identity (85.0% similar) in 453 aa overlap (1-453:1-385)
10 20 30 40 50 60
pF1KE6 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVMHHHGRHFIHIR
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVM-----------
10 20 30 40
70 80 90 100 110 120
pF1KE6 HSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVLDYG
:::
XP_005 ---------------------------------------------------------DYG
50
130 140 150 160 170 180
pF1KE6 YVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRPVLSSRSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRPVLSSRSD
60 70 80 90 100 110
190 200 210 220 230 240
pF1KE6 QSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEEFCVGKSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEEFCVGKSE
120 130 140 150 160 170
250 260 270 280 290 300
pF1KE6 LRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSPLPFRLFP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSPLPFRLFP
180 190 200 210 220 230
310 320 330 340 350 360
pF1KE6 SVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQKAELAEGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQKAELAEGA
240 250 260 270 280 290
370 380 390 400 410 420
pF1KE6 LRWDLPRVQGGSQLSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFELPRHTCSGLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRWDLPRVQGGSQLSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFELPRHTCSGLQ
300 310 320 330 340 350
430 440 450
pF1KE6 VRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI
:::::::::::::::::::::::::::::::::
XP_005 VRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI
360 370 380
>>XP_016868279 (OMIM: 602296,612936) PREDICTED: AP-4 com (284 aa)
initn: 1678 init1: 1628 opt: 1628 Z-score: 1603.5 bits: 305.3 E(85289): 1.4e-82
Smith-Waterman score: 1773; 87.4% identity (87.4% similar) in 325 aa overlap (129-453:1-284)
100 110 120 130 140 150
pF1KE6 EGTISRNVALVYELLDEVLDYGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAE
::::::::::::::::::::::::::::::
XP_016 MLRNFIQTEAVVSKPFSLFDLSSVGLFGAE
10 20 30
160 170 180 190 200 210
pF1KE6 TQQSKVAPSSAASRPVLSSRSDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TQQSKVAPSSAASRPVLSSRSDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKS
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE6 FLPSGSEMRIGLTEEFCVGKSELRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FLPSGSEMRIGLTEEFCVGKSELRGYGPGIRVDEVSFHSSVNLDEFESHRILRLQPPQGE
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE6 LTVMRYQLSDDLPSPLPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTVMRYQLSDDLPSPLPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPR
160 170 180 190 200 210
340 350 360 370 380 390
pF1KE6 GVVSLSQELSSPEQKAELAEGALRWDLPRVQGGSQLSGLFQMDVPGPPGPPSHGLSTSAS
:::::::::::::::::::::::::::::::::::::::::
XP_016 GVVSLSQELSSPEQKAELAEGALRWDLPRVQGGSQLSGLFQ-------------------
220 230 240 250
400 410 420 430 440 450
pF1KE6 PLGLGPASLSFELPRHTCSGLQVRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI
:::::::::::::::::::::::::::::::::
XP_016 ----------------------VRFLRLAFRPCGNANPHKWVRHLSHSDAYVIRI
260 270 280
>>XP_016868280 (OMIM: 602296,612936) PREDICTED: AP-4 com (228 aa)
initn: 1568 init1: 1568 opt: 1568 Z-score: 1546.1 bits: 294.3 E(85289): 2.2e-79
Smith-Waterman score: 1568; 100.0% identity (100.0% similar) in 228 aa overlap (226-453:1-228)
200 210 220 230 240 250
pF1KE6 SVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEEFCVGKSELRGYGPGIRVDEVSF
::::::::::::::::::::::::::::::
XP_016 MRIGLTEEFCVGKSELRGYGPGIRVDEVSF
10 20 30
260 270 280 290 300 310
pF1KE6 HSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSPLPFRLFPSVQWDRGSGRLQVYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSPLPFRLFPSVQWDRGSGRLQVYL
40 50 60 70 80 90
320 330 340 350 360 370
pF1KE6 KLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQKAELAEGALRWDLPRVQGGSQLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQKAELAEGALRWDLPRVQGGSQLS
100 110 120 130 140 150
380 390 400 410 420 430
pF1KE6 GLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFELPRHTCSGLQVRFLRLAFRPCGNAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFELPRHTCSGLQVRFLRLAFRPCGNAN
160 170 180 190 200 210
440 450
pF1KE6 PHKWVRHLSHSDAYVIRI
::::::::::::::::::
XP_016 PHKWVRHLSHSDAYVIRI
220
>>NP_004059 (OMIM: 601024) AP-2 complex subunit mu isofo (435 aa)
initn: 474 init1: 136 opt: 559 Z-score: 553.6 bits: 111.6 E(85289): 4.3e-24
Smith-Waterman score: 643; 28.9% identity (63.4% similar) in 464 aa overlap (1-452:1-434)
10 20 30 40 50 60
pF1KE6 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVMHHHGRHFIHIR
::. .:: . ::. :: . .: : : :.... : .. . : . :.:..
NP_004 MIGGLFIYNHKGEVLISRVYRDDIG-RNAVDAFRVNVIHARQQVRSPVTNIARTSFFHVK
10 20 30 40 50
70 80 90 100 110 120
pF1KE6 HSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVLDYG
.:...:...:..::. ..:.: .. ... : :...: .:. : .:.::::::.::.:
NP_004 RSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFG
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE6 YVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRPVLSSRSD
: :.. : :..:: ... :. . . :.. :.:. . . : .. :
NP_004 YPQNSETGALKTFITQQGIKSQHQTKEEQSQI--------TSQVTGQIGWRREGIKYR--
120 130 140 150 160
190 200 210 220 230
pF1KE6 QSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEEFCV---G
.::.::::.: ...:.. .:..:.. :.:.. .::.: . : ..:..... . :
NP_004 ---RNELFLDVLESVNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQG
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE6 KS---ELRGYGP-GIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSP
:. : : .: .:. .::. : :..:.:.: . . ::.::. .:::. . :.
NP_004 KGTADETSKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDI--I
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE6 LPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQK
::::..: :. . : .:.: . .. .. . : ......: : .. ... . . :
NP_004 LPFRVIPLVR-EVGRTKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAK
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE6 AELAEGALRWDLPRVQGG--SQLSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFEL
. .:.:. : . :. : ::.:. ... :.. . : : : :..::.
NP_004 YKASENAIVWKIKRMAGMKESQISAEIELL-------PTNDKKKWARP----PISMNFEV
350 360 370 380 390
420 430 440 450
pF1KE6 PRHTCSGLQVRFLRLAFRPCGNANPH---KWVRHLSHSDAYVIRI
: . :::.::.:.. :.: : . : ::::....: : :
NP_004 P-FAPSGLKVRYLKV-FEPKLNYSDHDVIKWVRYIGRSGIYETRC
400 410 420 430
>>NP_001020376 (OMIM: 601024) AP-2 complex subunit mu is (433 aa)
initn: 474 init1: 136 opt: 515 Z-score: 510.5 bits: 103.6 E(85289): 1.1e-21
Smith-Waterman score: 641; 28.4% identity (64.0% similar) in 464 aa overlap (1-452:1-432)
10 20 30 40 50 60
pF1KE6 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTGLPGDESPVVMHHHGRHFIHIR
::. .:: . ::. :: . .: : : :.... : .. . : . :.:..
NP_001 MIGGLFIYNHKGEVLISRVYRDDIG-RNAVDAFRVNVIHARQQVRSPVTNIARTSFFHVK
10 20 30 40 50
70 80 90 100 110 120
pF1KE6 HSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGSLGEGTISRNVALVYELLDEVLDYG
.:...:...:..::. ..:.: .. ... : :...: .:. : .:.::::::.::.:
NP_001 RSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNFVLIYELLDEILDFG
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE6 YVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFGAETQQSKVAPSSAASRPVLSSRSD
: :.. : :..:: ... :. .. .::... :..... ..
NP_001 YPQNSETGALKTFITQQGIKSQ--------------TKEEQSQIT-SQVTGQIGWRREGI
120 130 140 150 160
190 200 210 220 230
pF1KE6 QSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRLKSFLPSGSEMRIGLTEEFCV---G
. ..::.::::.: ...:.. .:..:.. :.:.. .::.: . : ..:..... . :
NP_001 KYRRNELFLDVLESVNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQG
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE6 KS---ELRGYGP-GIRVDEVSFHSSVNLDEFESHRILRLQPPQGELTVMRYQLSDDLPSP
:. : : .: .:. .::. : :..:.:.: . . ::.::. .:::. . :.
NP_001 KGTADETSKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDI--I
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE6 LPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALNVRLHLPLPRGVVSLSQELSSPEQK
::::..: :. . : .:.: . .. .. . : ......: : .. ... . . :
NP_001 LPFRVIPLVR-EVGRTKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAK
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE6 AELAEGALRWDLPRVQGG--SQLSGLFQMDVPGPPGPPSHGLSTSASPLGLGPASLSFEL
. .:.:. : . :. : ::.:. ... :.. . : : : :..::.
NP_001 YKASENAIVWKIKRMAGMKESQISAEIELL-------PTNDKKKWARP----PISMNFEV
350 360 370 380 390
420 430 440 450
pF1KE6 PRHTCSGLQVRFLRLAFRPCGNANPH---KWVRHLSHSDAYVIRI
: . :::.::.:.. :.: : . : ::::....: : :
NP_001 P-FAPSGLKVRYLKV-FEPKLNYSDHDVIKWVRYIGRSGIYETRC
400 410 420 430
>>NP_001298127 (OMIM: 601024) AP-2 complex subunit mu is (460 aa)
initn: 488 init1: 136 opt: 515 Z-score: 510.2 bits: 103.6 E(85289): 1.1e-21
Smith-Waterman score: 628; 28.5% identity (62.1% similar) in 488 aa overlap (1-452:1-459)
10 20 30 40
pF1KE6 MISQFFILSSKGDPLIYKDFRGDSGGRDVAELFYRKLTG-LPGD----------ESPVVM
::. .:: . ::. :: . .: : :.:..:. . .: .::. .. :
NP_001 MIGGLFIYNHKGEVLISRVYRDDIGSRQAADSAVFSSSGPFPGEWLEANRRNAVDAFRVN
10 20 30 40 50 60
50 60 70 80 90
pF1KE6 HHHGRH-------------FIHIRHSGLYLVVTTSENVSPFSLLELLSRLATLLGDYCGS
:.:. :.:...:...:...:..::. ..:.: .. ... : :.
NP_001 VIHARQQVRSPVTNIARTSFFHVKRSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGK
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE6 LGEGTISRNVALVYELLDEVLDYGYVQTTSTEMLRNFIQTEAVVSKPFSLFDLSSVGLFG
..: .:. : .:.::::::.::.:: :.. : :..:: ... :. . . :..
NP_001 ISEENIKNNFVLIYELLDEILDFGYPQNSETGALKTFITQQGIKSQHQTKEEQSQI----
130 140 150 160 170
160 170 180 190 200 210
pF1KE6 AETQQSKVAPSSAASRPVLSSRSDQSQKNEVFLDVVERLSVLIASNGSLLKVDVQGEIRL
:.:. . . : .. : .::.::::.: ...:.. .:..:.. :.:.. .
NP_001 ----TSQVTGQIGWRREGIKYR-----RNELFLDVLESVNLLMSPQGQVLSAHVSGRVVM
180 190 200 210 220
220 230 240 250 260
pF1KE6 KSFLPSGSEMRIGLTEEFCV---GKS---ELRGYGP-GIRVDEVSFHSSVNLDEFESHRI
::.: . : ..:..... . ::. : : .: .:. .::. : :..:.:.:
NP_001 KSYLSGMPECKFGMNDKIVIEKQGKGTADETSKSGKQSIAIDDCTFHQCVRLSKFDSERS
230 240 250 260 270 280
270 280 290 300 310 320
pF1KE6 LRLQPPQGELTVMRYQLSDDLPSPLPFRLFPSVQWDRGSGRLQVYLKLRCDLLSKSQALN
. . ::.::. .:::. . :. ::::..: :. . : .:.: . .. .. . : .
NP_001 ISFIPPDGEFELMRYRTTKDI--ILPFRVIPLVR-EVGRTKLEVKVVIKSNFKPSLLAQK
290 300 310 320 330 340
330 340 350 360 370 380
pF1KE6 VRLHLPLPRGVVSLSQELSSPEQKAELAEGALRWDLPRVQGG--SQLSGLFQMDVPGPPG
.....: : .. ... . . : . .:.:. : . :. : ::.:. ...
NP_001 IEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMAGMKESQISAEIELL------
350 360 370 380 390
390 400 410 420 430 440
pF1KE6 PPSHGLSTSASPLGLGPASLSFELPRHTCSGLQVRFLRLAFRPCGNANPH---KWVRHLS
:.. . : : : :..::.: . :::.::.:.. :.: : . : ::::...
NP_001 -PTNDKKKWARP----PISMNFEVP-FAPSGLKVRYLKV-FEPKLNYSDHDVIKWVRYIG
400 410 420 430 440 450
450
pF1KE6 HSDAYVIRI
.: : :
NP_001 RSGIYETRC
460
453 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 13:29:58 2016 done: Tue Nov 8 13:29:59 2016
Total Scan time: 6.590 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]