Result of FASTA (omim) for
pFN21AE6457
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6457, 476 aa
1>>>pF1KE6457 476 - 476 aa - 476 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2660+/-0.000383; mu= 18.6902+/- 0.024
mean_var=88.5066+/-16.924, 0's: 0 Z-trim(114.4): 96 B-trim: 0 in 0/54
Lambda= 0.136328
statistics sampled from 24099 (24200) to 24099 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.651), E-opt: 0.2 (0.284), width: 16
Scan time: 7.530
The best scores are: opt bits E(85289)
NP_055279 (OMIM: 606749) tubulointerstitial nephri ( 476) 3395 678.1 1.4e-194
XP_006715125 (OMIM: 606749) PREDICTED: tubulointer ( 458) 3269 653.3 4e-187
XP_016866234 (OMIM: 606749) PREDICTED: tubulointer ( 438) 2982 596.8 3.8e-170
XP_016866235 (OMIM: 606749) PREDICTED: tubulointer ( 401) 2511 504.2 2.8e-142
XP_016866237 (OMIM: 606749) PREDICTED: tubulointer ( 309) 2121 427.4 2.8e-119
XP_016866236 (OMIM: 606749) PREDICTED: tubulointer ( 351) 2121 427.4 3.1e-119
XP_011512799 (OMIM: 606749) PREDICTED: tubulointer ( 426) 2121 427.5 3.5e-119
NP_071447 (OMIM: 616064) tubulointerstitial nephri ( 467) 1533 311.9 2.5e-84
XP_005271164 (OMIM: 616064) PREDICTED: tubulointer ( 362) 1324 270.7 4.9e-72
NP_001191344 (OMIM: 616064) tubulointerstitial nep ( 362) 1324 270.7 4.9e-72
XP_011540248 (OMIM: 616064) PREDICTED: tubulointer ( 408) 1283 262.7 1.4e-69
NP_001191343 (OMIM: 616064) tubulointerstitial nep ( 436) 1165 239.5 1.4e-62
XP_005271163 (OMIM: 616064) PREDICTED: tubulointer ( 440) 1145 235.5 2.2e-61
NP_001805 (OMIM: 170650,245000,245010,602365) dipe ( 463) 300 69.4 2.5e-11
XP_006716307 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 215 52.5 2.1e-06
XP_016868589 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 215 52.5 2.1e-06
NP_001899 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 215 52.5 2.1e-06
NP_680093 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 215 52.5 2.1e-06
XP_016868587 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 215 52.5 2.1e-06
XP_016868586 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 215 52.5 2.1e-06
NP_680091 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 215 52.5 2.1e-06
NP_680092 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 215 52.5 2.1e-06
XP_006716308 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 215 52.5 2.1e-06
XP_016868588 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 215 52.5 2.1e-06
XP_011542114 (OMIM: 116810) PREDICTED: cathepsin B ( 339) 215 52.5 2.1e-06
NP_680090 (OMIM: 116810) cathepsin B isoform 1 pre ( 339) 215 52.5 2.1e-06
NP_001324 (OMIM: 603308) cathepsin L2 preproprotei ( 334) 205 50.6 8.2e-06
NP_001188504 (OMIM: 603308) cathepsin L2 prepropro ( 334) 205 50.6 8.2e-06
NP_001304166 (OMIM: 116810) cathepsin B isoform 2 ( 215) 192 47.8 3.5e-05
XP_016868590 (OMIM: 116810) PREDICTED: cathepsin B ( 245) 192 47.9 3.9e-05
NP_001244902 (OMIM: 116880) cathepsin L1 isoform 2 ( 151) 188 46.9 4.7e-05
NP_666023 (OMIM: 116880) cathepsin L1 isoform 1 pr ( 333) 188 47.2 8.3e-05
NP_001244901 (OMIM: 116880) cathepsin L1 isoform 1 ( 333) 188 47.2 8.3e-05
NP_001244900 (OMIM: 116880) cathepsin L1 isoform 1 ( 333) 188 47.2 8.3e-05
XP_005251773 (OMIM: 116880) PREDICTED: cathepsin L ( 333) 188 47.2 8.3e-05
NP_001903 (OMIM: 116880) cathepsin L1 isoform 1 pr ( 333) 188 47.2 8.3e-05
XP_011516565 (OMIM: 116880) PREDICTED: cathepsin L ( 272) 164 42.4 0.0019
XP_016869782 (OMIM: 116880) PREDICTED: cathepsin L ( 272) 164 42.4 0.0019
>>NP_055279 (OMIM: 606749) tubulointerstitial nephritis (476 aa)
initn: 3395 init1: 3395 opt: 3395 Z-score: 3614.2 bits: 678.1 E(85289): 1.4e-194
Smith-Waterman score: 3395; 99.4% identity (99.8% similar) in 476 aa overlap (1-476:1-476)
10 20 30 40 50 60
pF1KE6 MWTGYKILIFSYLTTEIWMEKRYLSQREVDLEAYFTRNHTVLQGTRFKRAIFQGQYCRNF
:::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::
NP_055 MWTGYKILIFSYLTTEIWMEKQYLSQREVDLEAYFTRNHTVLQGTRFKRAIFQGQYCRNF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 GCCEDRDDGCVTEFYAANALCYCDKFCDRENSDCCPDYKSFCREEKEWPPHTQPWYPEGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 GCCEDRDDGCVTEFYAANALCYCDKFCDRENSDCCPDYKSFCREEKEWPPHTQPWYPEGC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 FKDGQHYEEGSVIKENCNSCTCSGQQWKCSQHVCLVRSELIEQVNKGDYGWTAQNYSQFW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 FKDGQHYEEGSVIKENCNSCTCSGQQWKCSQHVCLVRSELIEQVNKGDYGWTAQNYSQFW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 GMTLEDGFKFRLGTLPPSLMLLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNC
:::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::
NP_055 GMTLEDGFKFRLGTLPPSPMLLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNC
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 AASWAFSTASVAADRIAIQSKGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 AASWAFSTASVAADRIAIQSKGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 LVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 ETEIMKEIMQNGPVQAIMQVHEDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGT
::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::
NP_055 ETEIMKEIMQNGPVQAIMQVREDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGT
370 380 390 400 410 420
430 440 450 460 470
pF1KE6 LRGAQGQKEKFWIAANSWGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_055 LRGAQGQKEKFWIAANSWGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP
430 440 450 460 470
>>XP_006715125 (OMIM: 606749) PREDICTED: tubulointerstit (458 aa)
initn: 3269 init1: 3269 opt: 3269 Z-score: 3480.4 bits: 653.3 E(85289): 4e-187
Smith-Waterman score: 3269; 99.3% identity (99.8% similar) in 458 aa overlap (19-476:1-458)
10 20 30 40 50 60
pF1KE6 MWTGYKILIFSYLTTEIWMEKRYLSQREVDLEAYFTRNHTVLQGTRFKRAIFQGQYCRNF
:::.::::::::::::::::::::::::::::::::::::::
XP_006 MEKQYLSQREVDLEAYFTRNHTVLQGTRFKRAIFQGQYCRNF
10 20 30 40
70 80 90 100 110 120
pF1KE6 GCCEDRDDGCVTEFYAANALCYCDKFCDRENSDCCPDYKSFCREEKEWPPHTQPWYPEGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GCCEDRDDGCVTEFYAANALCYCDKFCDRENSDCCPDYKSFCREEKEWPPHTQPWYPEGC
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE6 FKDGQHYEEGSVIKENCNSCTCSGQQWKCSQHVCLVRSELIEQVNKGDYGWTAQNYSQFW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FKDGQHYEEGSVIKENCNSCTCSGQQWKCSQHVCLVRSELIEQVNKGDYGWTAQNYSQFW
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE6 GMTLEDGFKFRLGTLPPSLMLLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNC
:::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::
XP_006 GMTLEDGFKFRLGTLPPSPMLLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNC
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE6 AASWAFSTASVAADRIAIQSKGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AASWAFSTASVAADRIAIQSKGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRG
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE6 LVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSN
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE6 ETEIMKEIMQNGPVQAIMQVHEDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGT
::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::
XP_006 ETEIMKEIMQNGPVQAIMQVREDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGT
350 360 370 380 390 400
430 440 450 460 470
pF1KE6 LRGAQGQKEKFWIAANSWGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LRGAQGQKEKFWIAANSWGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP
410 420 430 440 450
>>XP_016866234 (OMIM: 606749) PREDICTED: tubulointerstit (438 aa)
initn: 2979 init1: 2979 opt: 2982 Z-score: 3175.6 bits: 596.8 E(85289): 3.8e-170
Smith-Waterman score: 2982; 97.0% identity (98.6% similar) in 429 aa overlap (1-428:1-429)
10 20 30 40 50 60
pF1KE6 MWTGYKILIFSYLTTEIWMEKRYLSQREVDLEAYFTRNHTVLQGTRFKRAIFQGQYCRNF
:::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::
XP_016 MWTGYKILIFSYLTTEIWMEKQYLSQREVDLEAYFTRNHTVLQGTRFKRAIFQGQYCRNF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 GCCEDRDDGCVTEFYAANALCYCDKFCDRENSDCCPDYKSFCREEKEWPPHTQPWYPEGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GCCEDRDDGCVTEFYAANALCYCDKFCDRENSDCCPDYKSFCREEKEWPPHTQPWYPEGC
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 FKDGQHYEEGSVIKENCNSCTCSGQQWKCSQHVCLVRSELIEQVNKGDYGWTAQNYSQFW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKDGQHYEEGSVIKENCNSCTCSGQQWKCSQHVCLVRSELIEQVNKGDYGWTAQNYSQFW
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 GMTLEDGFKFRLGTLPPSLMLLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNC
:::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::
XP_016 GMTLEDGFKFRLGTLPPSPMLLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNC
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 AASWAFSTASVAADRIAIQSKGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AASWAFSTASVAADRIAIQSKGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 LVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 ETEIMKEIMQNGPVQAIMQVHEDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGT
::::::::::::::::::::.::::::::::::::::::::::::::::::::::::
XP_016 ETEIMKEIMQNGPVQAIMQVREDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGLLP
370 380 390 400 410 420
430 440 450 460 470
pF1KE6 LRG-AQGQKEKFWIAANSWGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP
. : ..:..
XP_016 IPGESHGERMAISGFFEE
430
>>XP_016866235 (OMIM: 606749) PREDICTED: tubulointerstit (401 aa)
initn: 2511 init1: 2511 opt: 2511 Z-score: 2675.5 bits: 504.2 E(85289): 2.8e-142
Smith-Waterman score: 2629; 83.6% identity (84.0% similar) in 476 aa overlap (1-476:1-401)
10 20 30 40 50 60
pF1KE6 MWTGYKILIFSYLTTEIWMEKRYLSQREVDLEAYFTRNHTVLQGTRFKRAIFQGQYCRNF
:::::::::::::::::::::.::::::::::::::::::::::
XP_016 MWTGYKILIFSYLTTEIWMEKQYLSQREVDLEAYFTRNHTVLQG----------------
10 20 30 40
70 80 90 100 110 120
pF1KE6 GCCEDRDDGCVTEFYAANALCYCDKFCDRENSDCCPDYKSFCREEKEWPPHTQPWYPEGC
:
XP_016 -----------------------------------------------------------C
130 140 150 160 170 180
pF1KE6 FKDGQHYEEGSVIKENCNSCTCSGQQWKCSQHVCLVRSELIEQVNKGDYGWTAQNYSQFW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKDGQHYEEGSVIKENCNSCTCSGQQWKCSQHVCLVRSELIEQVNKGDYGWTAQNYSQFW
50 60 70 80 90 100
190 200 210 220 230 240
pF1KE6 GMTLEDGFKFRLGTLPPSLMLLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNC
:::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::
XP_016 GMTLEDGFKFRLGTLPPSPMLLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNC
110 120 130 140 150 160
250 260 270 280 290 300
pF1KE6 AASWAFSTASVAADRIAIQSKGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AASWAFSTASVAADRIAIQSKGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRG
170 180 190 200 210 220
310 320 330 340 350 360
pF1KE6 LVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSN
230 240 250 260 270 280
370 380 390 400 410 420
pF1KE6 ETEIMKEIMQNGPVQAIMQVHEDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGT
::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::
XP_016 ETEIMKEIMQNGPVQAIMQVREDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGT
290 300 310 320 330 340
430 440 450 460 470
pF1KE6 LRGAQGQKEKFWIAANSWGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRGAQGQKEKFWIAANSWGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP
350 360 370 380 390 400
>>XP_016866237 (OMIM: 606749) PREDICTED: tubulointerstit (309 aa)
initn: 2121 init1: 2121 opt: 2121 Z-score: 2262.4 bits: 427.4 E(85289): 2.8e-119
Smith-Waterman score: 2121; 99.3% identity (99.7% similar) in 306 aa overlap (171-476:4-309)
150 160 170 180 190 200
pF1KE6 TCSGQQWKCSQHVCLVRSELIEQVNKGDYGWTAQNYSQFWGMTLEDGFKFRLGTLPPSLM
:::::::::::::::::::::::::::: :
XP_016 MGRWTAQNYSQFWGMTLEDGFKFRLGTLPPSPM
10 20 30
210 220 230 240 250 260
pF1KE6 LLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNCAASWAFSTASVAADRIAIQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNCAASWAFSTASVAADRIAIQS
40 50 60 70 80 90
270 280 290 300 310 320
pF1KE6 KGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRGLVSHACYPLFKDQNATNNGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRGLVSHACYPLFKDQNATNNGC
100 110 120 130 140 150
330 340 350 360 370 380
pF1KE6 AMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSNETEIMKEIMQNGPVQAIMQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSNETEIMKEIMQNGPVQAIMQV
160 170 180 190 200 210
390 400 410 420 430 440
pF1KE6 HEDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGTLRGAQGQKEKFWIAANSWGK
.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 REDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGTLRGAQGQKEKFWIAANSWGK
220 230 240 250 260 270
450 460 470
pF1KE6 SWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP
::::::::::::::::::::::::::::::::::::
XP_016 SWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP
280 290 300
>>XP_016866236 (OMIM: 606749) PREDICTED: tubulointerstit (351 aa)
initn: 2395 init1: 2121 opt: 2121 Z-score: 2261.7 bits: 427.4 E(85289): 3.1e-119
Smith-Waterman score: 2148; 72.9% identity (73.3% similar) in 476 aa overlap (1-476:1-351)
10 20 30 40 50 60
pF1KE6 MWTGYKILIFSYLTTEIWMEKRYLSQREVDLEAYFTRNHTVLQGTRFKRAIFQGQYCRNF
:::::::::::::::::::::.::::::::::::::::::::::
XP_016 MWTGYKILIFSYLTTEIWMEKQYLSQREVDLEAYFTRNHTVLQGR---------------
10 20 30 40
70 80 90 100 110 120
pF1KE6 GCCEDRDDGCVTEFYAANALCYCDKFCDRENSDCCPDYKSFCREEKEWPPHTQPWYPEGC
XP_016 ------------------------------------------------------------
130 140 150 160 170 180
pF1KE6 FKDGQHYEEGSVIKENCNSCTCSGQQWKCSQHVCLVRSELIEQVNKGDYGWTAQNYSQFW
::::::::::
XP_016 --------------------------------------------------WTAQNYSQFW
50
190 200 210 220 230 240
pF1KE6 GMTLEDGFKFRLGTLPPSLMLLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNC
:::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::
XP_016 GMTLEDGFKFRLGTLPPSPMLLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNC
60 70 80 90 100 110
250 260 270 280 290 300
pF1KE6 AASWAFSTASVAADRIAIQSKGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AASWAFSTASVAADRIAIQSKGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRG
120 130 140 150 160 170
310 320 330 340 350 360
pF1KE6 LVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSN
180 190 200 210 220 230
370 380 390 400 410 420
pF1KE6 ETEIMKEIMQNGPVQAIMQVHEDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGT
::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::
XP_016 ETEIMKEIMQNGPVQAIMQVREDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGT
240 250 260 270 280 290
430 440 450 460 470
pF1KE6 LRGAQGQKEKFWIAANSWGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRGAQGQKEKFWIAANSWGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP
300 310 320 330 340 350
>>XP_011512799 (OMIM: 606749) PREDICTED: tubulointerstit (426 aa)
initn: 3001 init1: 2121 opt: 2121 Z-score: 2260.6 bits: 427.5 E(85289): 3.5e-119
Smith-Waterman score: 2902; 88.9% identity (89.3% similar) in 476 aa overlap (1-476:1-426)
10 20 30 40 50 60
pF1KE6 MWTGYKILIFSYLTTEIWMEKRYLSQREVDLEAYFTRNHTVLQGTRFKRAIFQGQYCRNF
:::::::::::::::::::::.::::::::::::::::::::::::::::::::::::::
XP_011 MWTGYKILIFSYLTTEIWMEKQYLSQREVDLEAYFTRNHTVLQGTRFKRAIFQGQYCRNF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 GCCEDRDDGCVTEFYAANALCYCDKFCDRENSDCCPDYKSFCREEKEWPPHTQPWYPEGC
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GCCEDRDDGCVTEFYAANALCYCDKFCDRENSDCCPDYKSFCREEKEWPPHTQPWYPEG-
70 80 90 100 110
130 140 150 160 170 180
pF1KE6 FKDGQHYEEGSVIKENCNSCTCSGQQWKCSQHVCLVRSELIEQVNKGDYGWTAQNYSQFW
: ::::::::::
XP_011 ------------------------------------R-------------WTAQNYSQFW
120 130
190 200 210 220 230 240
pF1KE6 GMTLEDGFKFRLGTLPPSLMLLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNC
:::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::
XP_011 GMTLEDGFKFRLGTLPPSPMLLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNC
140 150 160 170 180 190
250 260 270 280 290 300
pF1KE6 AASWAFSTASVAADRIAIQSKGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AASWAFSTASVAADRIAIQSKGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRG
200 210 220 230 240 250
310 320 330 340 350 360
pF1KE6 LVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVSHACYPLFKDQNATNNGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSN
260 270 280 290 300 310
370 380 390 400 410 420
pF1KE6 ETEIMKEIMQNGPVQAIMQVHEDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGT
::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::
XP_011 ETEIMKEIMQNGPVQAIMQVREDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGT
320 330 340 350 360 370
430 440 450 460 470
pF1KE6 LRGAQGQKEKFWIAANSWGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRGAQGQKEKFWIAANSWGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP
380 390 400 410 420
>>NP_071447 (OMIM: 616064) tubulointerstitial nephritis (467 aa)
initn: 1459 init1: 662 opt: 1533 Z-score: 1635.1 bits: 311.9 E(85289): 2.5e-84
Smith-Waterman score: 1533; 49.6% identity (73.5% similar) in 427 aa overlap (54-474:45-463)
30 40 50 60 70 80
pF1KE6 LSQREVDLEAYFTRNHTVLQGTRFKRAIFQGQYCRNFG-CCEDRDDGCVTEFYAANALCY
:.::.. ::. : : :. . .: .::
NP_071 AGHLALGAQQGRGRRELAPGLHLRGIRDAGGRYCQEQDLCCRGRADDCALPYLGA--ICY
20 30 40 50 60 70
90 100 110 120 130 140
pF1KE6 CDKFCDRENSDCCPDYKSFCREEKEWPPHTQPWYP-EGCFKDGQHYEEGSVIKENCNSCT
:: ::.: ::::::. .:: :: :. : .::.. :. : .. .::: ::
NP_071 CDLFCNRTVSDCCPDFWDFCLGV---PP---PFPPIQGCMHGGRIYPVLGTYWDNCNRCT
80 90 100 110 120
150 160 170 180 190 200
pF1KE6 CS-GQQWKCSQHVCLVRSELIEQVNKGDYGWTAQNYSQFWGMTLEDGFKFRLGTLPPSLM
:. ..::.:.:. ::: ..:. .:.:.::: : :.: ::::::..:...::::. ::
NP_071 CQENRQWQCDQEPCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSS
130 140 150 160 170 180
210 220 230 240 250 260
pF1KE6 LLSMNEMTASLPATTDLPEFFVASYKWPGWTHGPLDQKNCAASWAFSTASVAADRIAIQS
...:.:. . : :: : :: :::. : :::: :::.:::::::.::.::..:.:
NP_071 VMNMHEIYTVLNPGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHS
190 200 210 220 230 240
270 280 290 300 310
pF1KE6 KGRYTANLSPQNLISCCAKNRHGCNSGSIDRAWWYLRKRGLVSHACYPLF---KDQNATN
:..: ::::::.:: .....:: .: .: :::.::.::.:: :::. .:. .
NP_071 LGHMTPVLSPQNLLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRERDEAGPA
250 260 270 280 290 300
320 330 340 350 360 370
pF1KE6 NGCAMASRSDGRGKRHATKPCPNNVEKSNRIYQCSPPYRVSSNETEIMKEIMQNGPVQAI
: : ::. :::::.:: :::. ..: ::: .: ::..::. :::::.:.::::::.
NP_071 PPCMMHSRAMGRGKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMENGPVQAL
310 320 330 340 350 360
380 390 400 410 420 430
pF1KE6 MQVHEDFFHYKTGIYRHVTSTNKESEKYRKLQTHAVKLTGWGTLRGAQGQKEKFWIAANS
:.:::::: :: ::: :. . . :.::. ::.::.:::: .:. :.: ::::
NP_071 MEVHEDFFLYKGGIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKYWTAANS
370 380 390 400 410 420
440 450 460 470
pF1KE6 WGKSWGENGYFRILRGVNESDIEKLIIAAWGQLTSSDEP
:: .::: :.:::.::::: :::......::.. :
NP_071 WGPAWGERGHFRIVRGVNECDIESFVLGVWGRVGMEDMGHH
430 440 450 460
>>XP_005271164 (OMIM: 616064) PREDICTED: tubulointerstit (362 aa)
initn: 1299 init1: 662 opt: 1324 Z-score: 1414.3 bits: 270.7 E(85289): 4.9e-72
Smith-Waterman score: 1324; 51.3% identity (75.8% similar) in 355 aa overlap (124-474:4-358)
100 110 120 130 140 150
pF1KE6 CCPDYKSFCREEKEWPPHTQPWYPEGCFKDGQHYEEGSVIKENCNSCTCS-GQQWKCSQH
:. : .. .::: :::. ..::.:.:.
XP_005 MHGGRIYPVLGTYWDNCNRCTCQENRQWQCDQE
10 20 30
160 170 180 190 200 210
pF1KE6 VCLVRSELIEQVNKGDYGWTAQNYSQFWGMTLEDGFKFRLGTLPPSLMLLSMNEMTASLP
::: ..:. .:.:.::: : :.: ::::::..:...::::. :: ...:.:. . :
XP_005 PCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSSVMNMHEIYTVLN
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE6 ATTDLPEFFVASYKWPGWTHGPLDQKNCAASWAFSTASVAADRIAIQSKGRYTANLSPQN
:: : :: :::. : :::: :::.:::::::.::.::..:.: :..: :::::
XP_005 PGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPVLSPQN
100 110 120 130 140 150
280 290 300 310 320
pF1KE6 LISCCAKNRHGCNSGSIDRAWWYLRKRGLVSHACYPLF---KDQNATNNGCAMASRSDGR
:.:: .....:: .: .: :::.::.::.:: :::. .:. . : : ::. ::
XP_005 LLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRERDEAGPAPPCMMHSRAMGR
160 170 180 190 200 210
330 340 350 360 370 380
pF1KE6 GKRHATKPCPNNVEKSNRIYQCSPPYRVSSNETEIMKEIMQNGPVQAIMQVHEDFFHYKT
:::.:: :::. ..: ::: .: ::..::. :::::.:.::::::.:.:::::: ::
XP_005 GKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMENGPVQALMEVHEDFFLYKG
220 230 240 250 260 270
390 400 410 420 430 440
pF1KE6 GIYRHVTSTNKESEKYRKLQTHAVKLTGWGTLRGAQGQKEKFWIAANSWGKSWGENGYFR
::: :. . . :.::. ::.::.:::: .:. :.: :::::: .::: :.::
XP_005 GIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERGHFR
280 290 300 310 320 330
450 460 470
pF1KE6 ILRGVNESDIEKLIIAAWGQLTSSDEP
:.::::: :::......::.. :
XP_005 IVRGVNECDIESFVLGVWGRVGMEDMGHH
340 350 360
>>NP_001191344 (OMIM: 616064) tubulointerstitial nephrit (362 aa)
initn: 1299 init1: 662 opt: 1324 Z-score: 1414.3 bits: 270.7 E(85289): 4.9e-72
Smith-Waterman score: 1324; 51.3% identity (75.8% similar) in 355 aa overlap (124-474:4-358)
100 110 120 130 140 150
pF1KE6 CCPDYKSFCREEKEWPPHTQPWYPEGCFKDGQHYEEGSVIKENCNSCTCS-GQQWKCSQH
:. : .. .::: :::. ..::.:.:.
NP_001 MHGGRIYPVLGTYWDNCNRCTCQENRQWQCDQE
10 20 30
160 170 180 190 200 210
pF1KE6 VCLVRSELIEQVNKGDYGWTAQNYSQFWGMTLEDGFKFRLGTLPPSLMLLSMNEMTASLP
::: ..:. .:.:.::: : :.: ::::::..:...::::. :: ...:.:. . :
NP_001 PCLVDPDMIKAINQGNYGWQAGNHSAFWGMTLDEGIRYRLGTIRPSSSVMNMHEIYTVLN
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE6 ATTDLPEFFVASYKWPGWTHGPLDQKNCAASWAFSTASVAADRIAIQSKGRYTANLSPQN
:: : :: :::. : :::: :::.:::::::.::.::..:.: :..: :::::
NP_001 PGEVLPTAFEASEKWPNLIHEPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPVLSPQN
100 110 120 130 140 150
280 290 300 310 320
pF1KE6 LISCCAKNRHGCNSGSIDRAWWYLRKRGLVSHACYPLF---KDQNATNNGCAMASRSDGR
:.:: .....:: .: .: :::.::.::.:: :::. .:. . : : ::. ::
NP_001 LLSCDTHQQQGCRGGRLDGAWWFLRRRGVVSDHCYPFSGRERDEAGPAPPCMMHSRAMGR
160 170 180 190 200 210
330 340 350 360 370 380
pF1KE6 GKRHATKPCPNNVEKSNRIYQCSPPYRVSSNETEIMKEIMQNGPVQAIMQVHEDFFHYKT
:::.:: :::. ..: ::: .: ::..::. :::::.:.::::::.:.:::::: ::
NP_001 GKRQATAHCPNSYVNNNDIYQVTPVYRLGSNDKEIMKELMENGPVQALMEVHEDFFLYKG
220 230 240 250 260 270
390 400 410 420 430 440
pF1KE6 GIYRHVTSTNKESEKYRKLQTHAVKLTGWGTLRGAQGQKEKFWIAANSWGKSWGENGYFR
::: :. . . :.::. ::.::.:::: .:. :.: :::::: .::: :.::
NP_001 GIYSHTPVSLGRPERYRRHGTHSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERGHFR
280 290 300 310 320 330
450 460 470
pF1KE6 ILRGVNESDIEKLIIAAWGQLTSSDEP
:.::::: :::......::.. :
NP_001 IVRGVNECDIESFVLGVWGRVGMEDMGHH
340 350 360
476 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 13:28:51 2016 done: Tue Nov 8 13:28:53 2016
Total Scan time: 7.530 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]