Result of FASTA (omim) for
pFN21AE6456
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6456, 553 aa
1>>>pF1KE6456 553 - 553 aa - 553 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.7292+/-0.000301; mu= 18.6200+/- 0.019
mean_var=113.1575+/-22.506, 0's: 0 Z-trim(120.2): 293 B-trim: 0 in 0/55
Lambda= 0.120568
statistics sampled from 34906 (35223) to 34906 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.743), E-opt: 0.2 (0.413), width: 16
Scan time: 8.790
The best scores are: opt bits E(85289)
NP_001034592 (OMIM: 610561) serine protease 53 pre ( 553) 3960 699.6 6.5e-201
XP_011544122 (OMIM: 610561) PREDICTED: serine prot ( 567) 3920 692.7 8.2e-199
XP_011544121 (OMIM: 610561) PREDICTED: serine prot ( 576) 3399 602.0 1.6e-171
XP_011544120 (OMIM: 610561) PREDICTED: serine prot ( 600) 2761 491.1 4.2e-138
XP_011544119 (OMIM: 610561) PREDICTED: serine prot ( 614) 2721 484.1 5.2e-136
XP_011544118 (OMIM: 610561) PREDICTED: serine prot ( 623) 2200 393.5 1e-108
NP_002764 (OMIM: 600823) prostasin preproprotein [ ( 343) 613 117.2 8.4e-26
XP_011520753 (OMIM: 613797) PREDICTED: serine prot ( 280) 611 116.8 9.3e-26
NP_690851 (OMIM: 613797) serine protease 33 precur ( 280) 611 116.8 9.3e-26
XP_011520754 (OMIM: 613797) PREDICTED: serine prot ( 280) 611 116.8 9.3e-26
NP_114154 (OMIM: 608018) serine protease 27 isofor ( 290) 597 114.4 5.2e-25
NP_001275930 (OMIM: 206200,609862) transmembrane p ( 802) 589 113.4 2.7e-24
NP_705837 (OMIM: 206200,609862) transmembrane prot ( 811) 589 113.4 2.7e-24
XP_016878460 (OMIM: 610560) PREDICTED: polyserase- ( 621) 544 105.5 5.2e-22
XP_016878459 (OMIM: 610560) PREDICTED: polyserase- ( 634) 544 105.5 5.3e-22
XP_016878458 (OMIM: 610560) PREDICTED: polyserase- ( 637) 544 105.5 5.3e-22
NP_001245220 (OMIM: 610560) polyserase-2 isoform 3 ( 752) 544 105.6 5.9e-22
XP_016878457 (OMIM: 610560) PREDICTED: polyserase- ( 761) 544 105.6 6e-22
NP_001245219 (OMIM: 610560) polyserase-2 isoform 2 ( 850) 544 105.6 6.5e-22
NP_775773 (OMIM: 610560) polyserase-2 isoform 1 pr ( 855) 544 105.6 6.5e-22
NP_036599 (OMIM: 609341) tryptase gamma preproprot ( 321) 501 97.7 5.9e-20
NP_001275679 (OMIM: 606751) transmembrane protease ( 413) 500 97.6 7.9e-20
NP_001275680 (OMIM: 606751) transmembrane protease ( 448) 500 97.7 8.3e-20
NP_110397 (OMIM: 606751) transmembrane protease se ( 457) 500 97.7 8.5e-20
NP_115780 (OMIM: 605511) transmembrane protease se ( 327) 495 96.7 1.2e-19
NP_076927 (OMIM: 605511) transmembrane protease se ( 454) 495 96.8 1.5e-19
XP_011526284 (OMIM: 610477) PREDICTED: transmembra ( 562) 490 96.0 3.3e-19
NP_068813 (OMIM: 606797) suppressor of tumorigenic ( 855) 492 96.6 3.4e-19
XP_011526282 (OMIM: 610477) PREDICTED: transmembra ( 690) 490 96.1 3.8e-19
NP_892018 (OMIM: 610477) transmembrane protease se (1059) 490 96.3 5e-19
XP_011526280 (OMIM: 610477) PREDICTED: transmembra (1093) 490 96.3 5.2e-19
XP_011520749 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 481 94.3 6.9e-19
XP_011520748 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 481 94.3 6.9e-19
NP_001231924 (OMIM: 610050) transmembrane protease ( 563) 479 94.1 1.2e-18
NP_001193718 (OMIM: 610050) transmembrane protease ( 532) 475 93.4 1.9e-18
NP_001070731 (OMIM: 610050) transmembrane protease ( 567) 475 93.4 2e-18
NP_001243246 (OMIM: 605511) transmembrane protease ( 453) 463 91.2 7.3e-18
NP_940866 (OMIM: 615144) serine protease 55 isofor ( 352) 457 90.1 1.3e-17
NP_254275 (OMIM: 609443) chymotrypsin-like elastas ( 269) 452 89.1 1.9e-17
XP_011528035 (OMIM: 602060) PREDICTED: transmembra ( 384) 453 89.4 2.2e-17
XP_005261100 (OMIM: 602060) PREDICTED: transmembra ( 452) 453 89.5 2.4e-17
XP_011528033 (OMIM: 602060) PREDICTED: transmembra ( 492) 453 89.5 2.6e-17
NP_005647 (OMIM: 602060) transmembrane protease se ( 492) 453 89.5 2.6e-17
NP_001128571 (OMIM: 602060) transmembrane protease ( 529) 453 89.6 2.7e-17
XP_016882221 (OMIM: 142440) PREDICTED: serine prot ( 393) 446 88.2 5.1e-17
NP_892028 (OMIM: 142440) serine protease hepsin pr ( 417) 446 88.3 5.3e-17
NP_002142 (OMIM: 142440) serine protease hepsin pr ( 417) 446 88.3 5.3e-17
XP_016882220 (OMIM: 142440) PREDICTED: serine prot ( 417) 446 88.3 5.3e-17
XP_006723244 (OMIM: 142440) PREDICTED: serine prot ( 417) 446 88.3 5.3e-17
XP_005258895 (OMIM: 142440) PREDICTED: serine prot ( 417) 446 88.3 5.3e-17
>>NP_001034592 (OMIM: 610561) serine protease 53 precurs (553 aa)
initn: 3960 init1: 3960 opt: 3960 Z-score: 3728.0 bits: 699.6 E(85289): 6.5e-201
Smith-Waterman score: 3960; 100.0% identity (100.0% similar) in 553 aa overlap (1-553:1-553)
10 20 30 40 50 60
pF1KE6 MKWCWGPVLLIAGATVLMEGLQAAQRACGQRGPGPPKPQEGNTVPGEWPWQASVRRQGAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKWCWGPVLLIAGATVLMEGLQAAQRACGQRGPGPPKPQEGNTVPGEWPWQASVRRQGAH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ICSGSLVADTWVLTAAHCFEKAAATELNSWSVVLGSLQREGLSPGAEEVGVAALQLPRAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ICSGSLVADTWVLTAAHCFEKAAATELNSWSVVLGSLQREGLSPGAEEVGVAALQLPRAY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 NHYSQGSDLALLQLAHPTTHTPLCLPQPAHRFPFGASCWATGWDQDTSDAPGTLRNLRLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NHYSQGSDLALLQLAHPTTHTPLCLPQPAHRFPFGASCWATGWDQDTSDAPGTLRNLRLR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 LISRPTCNCIYNQLHQRHLSNPARPGMLCGGPQPGVQGPCQGDSGGPVLCLEPDGHWVQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LISRPTCNCIYNQLHQRHLSNPARPGMLCGGPQPGVQGPCQGDSGGPVLCLEPDGHWVQA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 GIISFASSCAQEDAPVLLTNTAAHSSWLQARVQGAAFLAQSPETPEMSDEDSCVACGSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GIISFASSCAQEDAPVLLTNTAAHSSWLQARVQGAAFLAQSPETPEMSDEDSCVACGSLR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 TAGPQAGAPSPWPWEARLMHQGQLACGGALVSEEAVLTAAHCFIGRQAPEEWSVGLGTRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TAGPQAGAPSPWPWEARLMHQGQLACGGALVSEEAVLTAAHCFIGRQAPEEWSVGLGTRP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 EEWGLKQLILHGAYTHPEGGYDMALLLLAQPVTLGASLRPLCLPYPDHHLPDGERGWVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEWGLKQLILHGAYTHPEGGYDMALLLLAQPVTLGASLRPLCLPYPDHHLPDGERGWVLG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 RARPGAGISSLQTVPVTLLGPRACSRLHAAPGGDGSPILPGMVCTSAVGELPSCEGLSGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RARPGAGISSLQTVPVTLLGPRACSRLHAAPGGDGSPILPGMVCTSAVGELPSCEGLSGA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 PLVHEVRGTWFLAGLHSFGDACQGPARPAVFTALPAYEDWVSSLDWQVYFAEEPEPEAEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLVHEVRGTWFLAGLHSFGDACQGPARPAVFTALPAYEDWVSSLDWQVYFAEEPEPEAEP
490 500 510 520 530 540
550
pF1KE6 GSCLANISQPTSC
:::::::::::::
NP_001 GSCLANISQPTSC
550
>>XP_011544122 (OMIM: 610561) PREDICTED: serine protease (567 aa)
initn: 3920 init1: 3920 opt: 3920 Z-score: 3690.3 bits: 692.7 E(85289): 8.2e-199
Smith-Waterman score: 3920; 100.0% identity (100.0% similar) in 548 aa overlap (1-548:1-548)
10 20 30 40 50 60
pF1KE6 MKWCWGPVLLIAGATVLMEGLQAAQRACGQRGPGPPKPQEGNTVPGEWPWQASVRRQGAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MKWCWGPVLLIAGATVLMEGLQAAQRACGQRGPGPPKPQEGNTVPGEWPWQASVRRQGAH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ICSGSLVADTWVLTAAHCFEKAAATELNSWSVVLGSLQREGLSPGAEEVGVAALQLPRAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ICSGSLVADTWVLTAAHCFEKAAATELNSWSVVLGSLQREGLSPGAEEVGVAALQLPRAY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 NHYSQGSDLALLQLAHPTTHTPLCLPQPAHRFPFGASCWATGWDQDTSDAPGTLRNLRLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NHYSQGSDLALLQLAHPTTHTPLCLPQPAHRFPFGASCWATGWDQDTSDAPGTLRNLRLR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 LISRPTCNCIYNQLHQRHLSNPARPGMLCGGPQPGVQGPCQGDSGGPVLCLEPDGHWVQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LISRPTCNCIYNQLHQRHLSNPARPGMLCGGPQPGVQGPCQGDSGGPVLCLEPDGHWVQA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 GIISFASSCAQEDAPVLLTNTAAHSSWLQARVQGAAFLAQSPETPEMSDEDSCVACGSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GIISFASSCAQEDAPVLLTNTAAHSSWLQARVQGAAFLAQSPETPEMSDEDSCVACGSLR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 TAGPQAGAPSPWPWEARLMHQGQLACGGALVSEEAVLTAAHCFIGRQAPEEWSVGLGTRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TAGPQAGAPSPWPWEARLMHQGQLACGGALVSEEAVLTAAHCFIGRQAPEEWSVGLGTRP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 EEWGLKQLILHGAYTHPEGGYDMALLLLAQPVTLGASLRPLCLPYPDHHLPDGERGWVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEWGLKQLILHGAYTHPEGGYDMALLLLAQPVTLGASLRPLCLPYPDHHLPDGERGWVLG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 RARPGAGISSLQTVPVTLLGPRACSRLHAAPGGDGSPILPGMVCTSAVGELPSCEGLSGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RARPGAGISSLQTVPVTLLGPRACSRLHAAPGGDGSPILPGMVCTSAVGELPSCEGLSGA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 PLVHEVRGTWFLAGLHSFGDACQGPARPAVFTALPAYEDWVSSLDWQVYFAEEPEPEAEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLVHEVRGTWFLAGLHSFGDACQGPARPAVFTALPAYEDWVSSLDWQVYFAEEPEPEAEP
490 500 510 520 530 540
550
pF1KE6 GSCLANISQPTSC
::::::::
XP_011 GSCLANISMWPRGLLPNPASPGPFSLQ
550 560
>>XP_011544121 (OMIM: 610561) PREDICTED: serine protease (576 aa)
initn: 3399 init1: 3399 opt: 3399 Z-score: 3200.4 bits: 602.0 E(85289): 1.6e-171
Smith-Waterman score: 3399; 100.0% identity (100.0% similar) in 475 aa overlap (1-475:1-475)
10 20 30 40 50 60
pF1KE6 MKWCWGPVLLIAGATVLMEGLQAAQRACGQRGPGPPKPQEGNTVPGEWPWQASVRRQGAH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MKWCWGPVLLIAGATVLMEGLQAAQRACGQRGPGPPKPQEGNTVPGEWPWQASVRRQGAH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ICSGSLVADTWVLTAAHCFEKAAATELNSWSVVLGSLQREGLSPGAEEVGVAALQLPRAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ICSGSLVADTWVLTAAHCFEKAAATELNSWSVVLGSLQREGLSPGAEEVGVAALQLPRAY
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 NHYSQGSDLALLQLAHPTTHTPLCLPQPAHRFPFGASCWATGWDQDTSDAPGTLRNLRLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NHYSQGSDLALLQLAHPTTHTPLCLPQPAHRFPFGASCWATGWDQDTSDAPGTLRNLRLR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 LISRPTCNCIYNQLHQRHLSNPARPGMLCGGPQPGVQGPCQGDSGGPVLCLEPDGHWVQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LISRPTCNCIYNQLHQRHLSNPARPGMLCGGPQPGVQGPCQGDSGGPVLCLEPDGHWVQA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 GIISFASSCAQEDAPVLLTNTAAHSSWLQARVQGAAFLAQSPETPEMSDEDSCVACGSLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GIISFASSCAQEDAPVLLTNTAAHSSWLQARVQGAAFLAQSPETPEMSDEDSCVACGSLR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 TAGPQAGAPSPWPWEARLMHQGQLACGGALVSEEAVLTAAHCFIGRQAPEEWSVGLGTRP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TAGPQAGAPSPWPWEARLMHQGQLACGGALVSEEAVLTAAHCFIGRQAPEEWSVGLGTRP
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 EEWGLKQLILHGAYTHPEGGYDMALLLLAQPVTLGASLRPLCLPYPDHHLPDGERGWVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEWGLKQLILHGAYTHPEGGYDMALLLLAQPVTLGASLRPLCLPYPDHHLPDGERGWVLG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 RARPGAGISSLQTVPVTLLGPRACSRLHAAPGGDGSPILPGMVCTSAVGELPSCEGLSGA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RARPGAGISSLQTVPVTLLGPRACSRLHAAPGGDGSPILPGMVCTSAVGELPSCEANQPA
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 PLVHEVRGTWFLAGLHSFGDACQGPARPAVFTALPAYEDWVSSLDWQVYFAEEPEPEAEP
XP_011 ADRGPGHSQDKRMQAGKWHYCPCPPHPVMCDSRHQGRPRSPAAVGRNLPGATGAHSPPCR
490 500 510 520 530 540
>>XP_011544120 (OMIM: 610561) PREDICTED: serine protease (600 aa)
initn: 2751 init1: 2751 opt: 2761 Z-score: 2600.5 bits: 491.1 E(85289): 4.2e-138
Smith-Waterman score: 3739; 92.0% identity (92.0% similar) in 585 aa overlap (16-553:16-600)
10 20 30 40 50 60
pF1KE6 MKWCWGPVLLIAGATVLMEGLQAAQRACGQRGPGPPKPQEGNTVPGEWPWQASVRRQGAH
:::::::::::::::::::::::::::::::::::::::::::::
XP_011 MKWCWGPVLLIAGATVLMEGLQAAQRACGQRGPGPPKPQEGNTVPGEWPWQASVRRQGAH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ICSGSLVADTWVLTAAHCFEKAAATELNSWSVVLGSLQREGLSPGAEEVGVAALQLPRAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ICSGSLVADTWVLTAAHCFEKAAATELNSWSVVLGSLQREGLSPGAEEVGVAALQLPRAY
70 80 90 100 110 120
130 140 150 160
pF1KE6 NHYSQGSDLALLQLAHPTTHTPLCLPQPAHRFPFGASCWATGWDQDTSD-----------
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NHYSQGSDLALLQLAHPTTHTPLCLPQPAHRFPFGASCWATGWDQDTSDGKCWPRLKLGE
130 140 150 160 170 180
170 180 190
pF1KE6 ------------------------------------APGTLRNLRLRLISRPTCNCIYNQ
::::::::::::::::::::::::
XP_011 ALCLPSVTVSAPNCPGFQSPLLPRSQTLAPAPSLSPAPGTLRNLRLRLISRPTCNCIYNQ
190 200 210 220 230 240
200 210 220 230 240 250
pF1KE6 LHQRHLSNPARPGMLCGGPQPGVQGPCQGDSGGPVLCLEPDGHWVQAGIISFASSCAQED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LHQRHLSNPARPGMLCGGPQPGVQGPCQGDSGGPVLCLEPDGHWVQAGIISFASSCAQED
250 260 270 280 290 300
260 270 280 290 300 310
pF1KE6 APVLLTNTAAHSSWLQARVQGAAFLAQSPETPEMSDEDSCVACGSLRTAGPQAGAPSPWP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APVLLTNTAAHSSWLQARVQGAAFLAQSPETPEMSDEDSCVACGSLRTAGPQAGAPSPWP
310 320 330 340 350 360
320 330 340 350 360 370
pF1KE6 WEARLMHQGQLACGGALVSEEAVLTAAHCFIGRQAPEEWSVGLGTRPEEWGLKQLILHGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WEARLMHQGQLACGGALVSEEAVLTAAHCFIGRQAPEEWSVGLGTRPEEWGLKQLILHGA
370 380 390 400 410 420
380 390 400 410 420 430
pF1KE6 YTHPEGGYDMALLLLAQPVTLGASLRPLCLPYPDHHLPDGERGWVLGRARPGAGISSLQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YTHPEGGYDMALLLLAQPVTLGASLRPLCLPYPDHHLPDGERGWVLGRARPGAGISSLQT
430 440 450 460 470 480
440 450 460 470 480 490
pF1KE6 VPVTLLGPRACSRLHAAPGGDGSPILPGMVCTSAVGELPSCEGLSGAPLVHEVRGTWFLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPVTLLGPRACSRLHAAPGGDGSPILPGMVCTSAVGELPSCEGLSGAPLVHEVRGTWFLA
490 500 510 520 530 540
500 510 520 530 540 550
pF1KE6 GLHSFGDACQGPARPAVFTALPAYEDWVSSLDWQVYFAEEPEPEAEPGSCLANISQPTSC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLHSFGDACQGPARPAVFTALPAYEDWVSSLDWQVYFAEEPEPEAEPGSCLANISQPTSC
550 560 570 580 590 600
>>XP_011544119 (OMIM: 610561) PREDICTED: serine protease (614 aa)
initn: 2711 init1: 2711 opt: 2721 Z-score: 2562.7 bits: 484.1 E(85289): 5.2e-136
Smith-Waterman score: 3699; 91.9% identity (91.9% similar) in 580 aa overlap (16-548:16-595)
10 20 30 40 50 60
pF1KE6 MKWCWGPVLLIAGATVLMEGLQAAQRACGQRGPGPPKPQEGNTVPGEWPWQASVRRQGAH
:::::::::::::::::::::::::::::::::::::::::::::
XP_011 MKWCWGPVLLIAGATVLMEGLQAAQRACGQRGPGPPKPQEGNTVPGEWPWQASVRRQGAH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ICSGSLVADTWVLTAAHCFEKAAATELNSWSVVLGSLQREGLSPGAEEVGVAALQLPRAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ICSGSLVADTWVLTAAHCFEKAAATELNSWSVVLGSLQREGLSPGAEEVGVAALQLPRAY
70 80 90 100 110 120
130 140 150 160
pF1KE6 NHYSQGSDLALLQLAHPTTHTPLCLPQPAHRFPFGASCWATGWDQDTSD-----------
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NHYSQGSDLALLQLAHPTTHTPLCLPQPAHRFPFGASCWATGWDQDTSDGKCWPRLKLGE
130 140 150 160 170 180
170 180 190
pF1KE6 ------------------------------------APGTLRNLRLRLISRPTCNCIYNQ
::::::::::::::::::::::::
XP_011 ALCLPSVTVSAPNCPGFQSPLLPRSQTLAPAPSLSPAPGTLRNLRLRLISRPTCNCIYNQ
190 200 210 220 230 240
200 210 220 230 240 250
pF1KE6 LHQRHLSNPARPGMLCGGPQPGVQGPCQGDSGGPVLCLEPDGHWVQAGIISFASSCAQED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LHQRHLSNPARPGMLCGGPQPGVQGPCQGDSGGPVLCLEPDGHWVQAGIISFASSCAQED
250 260 270 280 290 300
260 270 280 290 300 310
pF1KE6 APVLLTNTAAHSSWLQARVQGAAFLAQSPETPEMSDEDSCVACGSLRTAGPQAGAPSPWP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APVLLTNTAAHSSWLQARVQGAAFLAQSPETPEMSDEDSCVACGSLRTAGPQAGAPSPWP
310 320 330 340 350 360
320 330 340 350 360 370
pF1KE6 WEARLMHQGQLACGGALVSEEAVLTAAHCFIGRQAPEEWSVGLGTRPEEWGLKQLILHGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WEARLMHQGQLACGGALVSEEAVLTAAHCFIGRQAPEEWSVGLGTRPEEWGLKQLILHGA
370 380 390 400 410 420
380 390 400 410 420 430
pF1KE6 YTHPEGGYDMALLLLAQPVTLGASLRPLCLPYPDHHLPDGERGWVLGRARPGAGISSLQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YTHPEGGYDMALLLLAQPVTLGASLRPLCLPYPDHHLPDGERGWVLGRARPGAGISSLQT
430 440 450 460 470 480
440 450 460 470 480 490
pF1KE6 VPVTLLGPRACSRLHAAPGGDGSPILPGMVCTSAVGELPSCEGLSGAPLVHEVRGTWFLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VPVTLLGPRACSRLHAAPGGDGSPILPGMVCTSAVGELPSCEGLSGAPLVHEVRGTWFLA
490 500 510 520 530 540
500 510 520 530 540 550
pF1KE6 GLHSFGDACQGPARPAVFTALPAYEDWVSSLDWQVYFAEEPEPEAEPGSCLANISQPTSC
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLHSFGDACQGPARPAVFTALPAYEDWVSSLDWQVYFAEEPEPEAEPGSCLANISMWPRG
550 560 570 580 590 600
XP_011 LLPNPASPGPFSLQ
610
>>XP_011544118 (OMIM: 610561) PREDICTED: serine protease (623 aa)
initn: 2190 init1: 2190 opt: 2200 Z-score: 2072.9 bits: 393.5 E(85289): 1e-108
Smith-Waterman score: 3178; 90.7% identity (90.7% similar) in 507 aa overlap (16-475:16-522)
10 20 30 40 50 60
pF1KE6 MKWCWGPVLLIAGATVLMEGLQAAQRACGQRGPGPPKPQEGNTVPGEWPWQASVRRQGAH
:::::::::::::::::::::::::::::::::::::::::::::
XP_011 MKWCWGPVLLIAGATVLMEGLQAAQRACGQRGPGPPKPQEGNTVPGEWPWQASVRRQGAH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 ICSGSLVADTWVLTAAHCFEKAAATELNSWSVVLGSLQREGLSPGAEEVGVAALQLPRAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ICSGSLVADTWVLTAAHCFEKAAATELNSWSVVLGSLQREGLSPGAEEVGVAALQLPRAY
70 80 90 100 110 120
130 140 150 160
pF1KE6 NHYSQGSDLALLQLAHPTTHTPLCLPQPAHRFPFGASCWATGWDQDTSD-----------
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NHYSQGSDLALLQLAHPTTHTPLCLPQPAHRFPFGASCWATGWDQDTSDGKCWPRLKLGE
130 140 150 160 170 180
170 180 190
pF1KE6 ------------------------------------APGTLRNLRLRLISRPTCNCIYNQ
::::::::::::::::::::::::
XP_011 ALCLPSVTVSAPNCPGFQSPLLPRSQTLAPAPSLSPAPGTLRNLRLRLISRPTCNCIYNQ
190 200 210 220 230 240
200 210 220 230 240 250
pF1KE6 LHQRHLSNPARPGMLCGGPQPGVQGPCQGDSGGPVLCLEPDGHWVQAGIISFASSCAQED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LHQRHLSNPARPGMLCGGPQPGVQGPCQGDSGGPVLCLEPDGHWVQAGIISFASSCAQED
250 260 270 280 290 300
260 270 280 290 300 310
pF1KE6 APVLLTNTAAHSSWLQARVQGAAFLAQSPETPEMSDEDSCVACGSLRTAGPQAGAPSPWP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APVLLTNTAAHSSWLQARVQGAAFLAQSPETPEMSDEDSCVACGSLRTAGPQAGAPSPWP
310 320 330 340 350 360
320 330 340 350 360 370
pF1KE6 WEARLMHQGQLACGGALVSEEAVLTAAHCFIGRQAPEEWSVGLGTRPEEWGLKQLILHGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WEARLMHQGQLACGGALVSEEAVLTAAHCFIGRQAPEEWSVGLGTRPEEWGLKQLILHGA
370 380 390 400 410 420
380 390 400 410 420 430
pF1KE6 YTHPEGGYDMALLLLAQPVTLGASLRPLCLPYPDHHLPDGERGWVLGRARPGAGISSLQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YTHPEGGYDMALLLLAQPVTLGASLRPLCLPYPDHHLPDGERGWVLGRARPGAGISSLQT
430 440 450 460 470 480
440 450 460 470 480 490
pF1KE6 VPVTLLGPRACSRLHAAPGGDGSPILPGMVCTSAVGELPSCEGLSGAPLVHEVRGTWFLA
::::::::::::::::::::::::::::::::::::::::::
XP_011 VPVTLLGPRACSRLHAAPGGDGSPILPGMVCTSAVGELPSCEANQPAADRGPGHSQDKRM
490 500 510 520 530 540
500 510 520 530 540 550
pF1KE6 GLHSFGDACQGPARPAVFTALPAYEDWVSSLDWQVYFAEEPEPEAEPGSCLANISQPTSC
XP_011 QAGKWHYCPCPPHPVMCDSRHQGRPRSPAAVGRNLPGATGAHSPPCRTGVSVDTPTPNSA
550 560 570 580 590 600
>>NP_002764 (OMIM: 600823) prostasin preproprotein [Homo (343 aa)
initn: 539 init1: 199 opt: 613 Z-score: 584.2 bits: 117.2 E(85289): 8.4e-26
Smith-Waterman score: 613; 36.2% identity (61.3% similar) in 326 aa overlap (6-311:8-323)
10 20 30 40 50
pF1KE6 MKWCWGPVLLIAGATVLMEGL-QAAQRACGQRGPGPPKPQE----GNT-VPGEWPWQA
:: : : : .:. :: ... : : ..: :: :.. : :.::::.
NP_002 MAQKGVLGPGQLGAVAILLYLGLLRSGTGAEGAEAPCGVAPQARITGGSSAVAGQWPWQV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 SVRRQGAHICSGSLVADTWVLTAAHCFEKAAATELNSWSVVLGSLQREGLSPGAEEVGVA
:. .:.:.:.::::.. :::.::::: . : .. : ::. : .. : :.. :.
NP_002 SITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKE--AYEVKLGAHQLDSYS---EDAKVS
70 80 90 100 110
120 130 140 150 160
pF1KE6 ALQ----LPRAYNHYSQGSDLALLQLAHPTTHT----PLCLPQPAHRFPFGASCWATGWD
.:. : .. ::: :.:::::..: : . :.::: :: : : .:::
NP_002 TLKDIIPHPSYLQEGSQG-DIALLQLSRPITFSRYIRPICLPAANASFPNGLHCTVTGWG
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE6 QDTSDA----PGTLRNLRLRLISRPTCNCIYNQLHQRHLSNPARPGMLCGGPQPGVQGPC
. . .. : :..:.. :::: ::::.:: . . . .. :.:.: : . :
NP_002 HVAPSVSLLTPKPLQQLEVPLISRETCNCLYNIDAKPEEPHFVQEDMVCAGYVEGGKDAC
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE6 QGDSGGPVLCLEPDGHWVQAGIISFASSCAQEDAPVLLTNTAAHSSWLQARVQGAAFLAQ
:::::::. : .: : .::.:....:. .. : . : .....::.:..: .
NP_002 QGDSGGPLSC-PVEGLWYLTGIVSWGDACGARNRPGVYTLASSYASWIQSKVTELQPRV-
240 250 260 270 280 290
290 300 310 320 330
pF1KE6 SPETPEMSDEDSCVACGS--LRTAGPQAGAPSPWPWEARLMHQGQLACGGALVSEEAVLT
:.: : :. :: . ::: ...: : :
NP_002 VPQTQE-SQPDSNL-CGSHLAFSSAPAQGLLRPILFLPLGLALGLLSPWLSEH
300 310 320 330 340
340 350 360 370 380 390
pF1KE6 AAHCFIGRQAPEEWSVGLGTRPEEWGLKQLILHGAYTHPEGGYDMALLLLAQPVTLGASL
>>XP_011520753 (OMIM: 613797) PREDICTED: serine protease (280 aa)
initn: 530 init1: 220 opt: 611 Z-score: 583.4 bits: 116.8 E(85289): 9.3e-26
Smith-Waterman score: 611; 38.2% identity (62.5% similar) in 280 aa overlap (4-272:6-278)
10 20 30 40 50
pF1KE6 MKWCWGPVLLIAGATVLMEGLQAAQRACGQRGPGPPKPQEG--NTVPGEWPWQASVRR
: .::.. ... .: ..: :::: : . : . ::::::::...
XP_011 MRGVSCLQVLLLLVLGAAGTQGRKSA--ACGQ--PRMSSRIVGGRDGRDGEWPWQASIQH
10 20 30 40 50
60 70 80 90 100 110
pF1KE6 QGAHICSGSLVADTWVLTAAHCFEKAAATELNSWSVVLGSLQREGLSPGAEEVGVAALQL
.:::.:.:::.: ::::::::: . : . : ::.:. . :: . : : . :
XP_011 RGAHVCGGSLIAPQWVLTAAHCFPRRALPA--EYRVRLGALRLGSTSPRTLSVPVRRVLL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE6 PRAYNHYSQGSDLALLQLAHPTTHT----PLCLPQPAHRFPFGASCWATGWDQDTSDAP-
: :.. . .::::::: .:. . :.::: :. : : :. : .::: . .:
XP_011 PPDYSEDGARGDLALLQLRRPVPLSARVQPVCLPVPGARPPPGTPCRVTGWGSLRPGVPL
120 130 140 150 160 170
180 190 200 210 220
pF1KE6 ---GTLRNLRLRLISRPTCNCIYN-QLHQRHLSNPARPGMLCGGPQPGVQGPCQGDSGGP
:...:. :.. ::. .:. . . :: ::.: : . ::::::::
XP_011 PEWRPLQGVRVPLLDSRTCDGLYHVGADVPQAERIVLPGSLCAGYPQGHKDACQGDSGGP
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE6 VLCLEPDGHWVQAGIISFASSCAQEDAPVLLTNTAAHSSWLQARVQGAAFLAQSPETPEM
. ::. .: :: .:..:....:: . : . :..:..: :.::::
XP_011 LTCLQ-SGSWVLVGVVSWGKGCALPNRPGVYTSVATYSPWIQARVSF
240 250 260 270 280
290 300 310 320 330 340
pF1KE6 SDEDSCVACGSLRTAGPQAGAPSPWPWEARLMHQGQLACGGALVSEEAVLTAAHCFIGRQ
>>NP_690851 (OMIM: 613797) serine protease 33 precursor (280 aa)
initn: 530 init1: 220 opt: 611 Z-score: 583.4 bits: 116.8 E(85289): 9.3e-26
Smith-Waterman score: 611; 38.2% identity (62.5% similar) in 280 aa overlap (4-272:6-278)
10 20 30 40 50
pF1KE6 MKWCWGPVLLIAGATVLMEGLQAAQRACGQRGPGPPKPQEG--NTVPGEWPWQASVRR
: .::.. ... .: ..: :::: : . : . ::::::::...
NP_690 MRGVSCLQVLLLLVLGAAGTQGRKSA--ACGQ--PRMSSRIVGGRDGRDGEWPWQASIQH
10 20 30 40 50
60 70 80 90 100 110
pF1KE6 QGAHICSGSLVADTWVLTAAHCFEKAAATELNSWSVVLGSLQREGLSPGAEEVGVAALQL
.:::.:.:::.: ::::::::: . : . : ::.:. . :: . : : . :
NP_690 RGAHVCGGSLIAPQWVLTAAHCFPRRALPA--EYRVRLGALRLGSTSPRTLSVPVRRVLL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE6 PRAYNHYSQGSDLALLQLAHPTTHT----PLCLPQPAHRFPFGASCWATGWDQDTSDAP-
: :.. . .::::::: .:. . :.::: :. : : :. : .::: . .:
NP_690 PPDYSEDGARGDLALLQLRRPVPLSARVQPVCLPVPGARPPPGTPCRVTGWGSLRPGVPL
120 130 140 150 160 170
180 190 200 210 220
pF1KE6 ---GTLRNLRLRLISRPTCNCIYN-QLHQRHLSNPARPGMLCGGPQPGVQGPCQGDSGGP
:...:. :.. ::. .:. . . :: ::.: : . ::::::::
NP_690 PEWRPLQGVRVPLLDSRTCDGLYHVGADVPQAERIVLPGSLCAGYPQGHKDACQGDSGGP
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE6 VLCLEPDGHWVQAGIISFASSCAQEDAPVLLTNTAAHSSWLQARVQGAAFLAQSPETPEM
. ::. .: :: .:..:....:: . : . :..:..: :.::::
NP_690 LTCLQ-SGSWVLVGVVSWGKGCALPNRPGVYTSVATYSPWIQARVSF
240 250 260 270 280
290 300 310 320 330 340
pF1KE6 SDEDSCVACGSLRTAGPQAGAPSPWPWEARLMHQGQLACGGALVSEEAVLTAAHCFIGRQ
>>XP_011520754 (OMIM: 613797) PREDICTED: serine protease (280 aa)
initn: 530 init1: 220 opt: 611 Z-score: 583.4 bits: 116.8 E(85289): 9.3e-26
Smith-Waterman score: 611; 38.2% identity (62.5% similar) in 280 aa overlap (4-272:6-278)
10 20 30 40 50
pF1KE6 MKWCWGPVLLIAGATVLMEGLQAAQRACGQRGPGPPKPQEG--NTVPGEWPWQASVRR
: .::.. ... .: ..: :::: : . : . ::::::::...
XP_011 MRGVSCLQVLLLLVLGAAGTQGRKSA--ACGQ--PRMSSRIVGGRDGRDGEWPWQASIQH
10 20 30 40 50
60 70 80 90 100 110
pF1KE6 QGAHICSGSLVADTWVLTAAHCFEKAAATELNSWSVVLGSLQREGLSPGAEEVGVAALQL
.:::.:.:::.: ::::::::: . : . : ::.:. . :: . : : . :
XP_011 RGAHVCGGSLIAPQWVLTAAHCFPRRALPA--EYRVRLGALRLGSTSPRTLSVPVRRVLL
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE6 PRAYNHYSQGSDLALLQLAHPTTHT----PLCLPQPAHRFPFGASCWATGWDQDTSDAP-
: :.. . .::::::: .:. . :.::: :. : : :. : .::: . .:
XP_011 PPDYSEDGARGDLALLQLRRPVPLSARVQPVCLPVPGARPPPGTPCRVTGWGSLRPGVPL
120 130 140 150 160 170
180 190 200 210 220
pF1KE6 ---GTLRNLRLRLISRPTCNCIYN-QLHQRHLSNPARPGMLCGGPQPGVQGPCQGDSGGP
:...:. :.. ::. .:. . . :: ::.: : . ::::::::
XP_011 PEWRPLQGVRVPLLDSRTCDGLYHVGADVPQAERIVLPGSLCAGYPQGHKDACQGDSGGP
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE6 VLCLEPDGHWVQAGIISFASSCAQEDAPVLLTNTAAHSSWLQARVQGAAFLAQSPETPEM
. ::. .: :: .:..:....:: . : . :..:..: :.::::
XP_011 LTCLQ-SGSWVLVGVVSWGKGCALPNRPGVYTSVATYSPWIQARVSF
240 250 260 270 280
290 300 310 320 330 340
pF1KE6 SDEDSCVACGSLRTAGPQAGAPSPWPWEARLMHQGQLACGGALVSEEAVLTAAHCFIGRQ
553 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 13:28:15 2016 done: Tue Nov 8 13:28:16 2016
Total Scan time: 8.790 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]