Result of FASTA (omim) for
pFN21AE6455
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6455, 569 aa
1>>>pF1KE6455 569 - 569 aa - 569 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.6297+/-0.000388; mu= -3.7926+/- 0.024
mean_var=306.0957+/-62.679, 0's: 0 Z-trim(122.7): 54 B-trim: 0 in 0/56
Lambda= 0.073307
statistics sampled from 41117 (41173) to 41117 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.778), E-opt: 0.2 (0.483), width: 16
Scan time: 8.670
The best scores are: opt bits E(85289)
NP_671724 (OMIM: 608416,616749) matrix metalloprot ( 569) 4040 440.7 5.9e-123
NP_002416 (OMIM: 185260) stromelysin-2 preproprote ( 476) 455 61.5 7e-09
NP_002413 (OMIM: 185250,614466) stromelysin-1 prep ( 477) 438 59.7 2.4e-08
NP_002420 (OMIM: 601807,611543) matrix metalloprot ( 508) 421 57.9 8.9e-08
XP_016880550 (OMIM: 608417) PREDICTED: matrix meta ( 409) 394 55.0 5.4e-07
NP_002417 (OMIM: 601046) macrophage metalloelastas ( 470) 393 55.0 6.5e-07
NP_004762 (OMIM: 604629,612529) matrix metalloprot ( 483) 389 54.5 8.9e-07
NP_001291371 (OMIM: 120355) neutrophil collagenase ( 444) 383 53.9 1.3e-06
XP_016873260 (OMIM: 120355) PREDICTED: neutrophil ( 444) 383 53.9 1.3e-06
XP_011541137 (OMIM: 120355) PREDICTED: neutrophil ( 444) 383 53.9 1.3e-06
NP_001291370 (OMIM: 120355) neutrophil collagenase ( 444) 383 53.9 1.3e-06
NP_002415 (OMIM: 120355) neutrophil collagenase is ( 467) 383 53.9 1.3e-06
XP_011541136 (OMIM: 120355) PREDICTED: neutrophil ( 476) 383 53.9 1.4e-06
NP_005931 (OMIM: 185261) stromelysin-3 preproprote ( 488) 379 53.5 1.9e-06
XP_011536658 (OMIM: 602285) PREDICTED: matrix meta ( 519) 358 51.3 9.1e-06
XP_011536659 (OMIM: 602285) PREDICTED: matrix meta ( 519) 358 51.3 9.1e-06
XP_011536657 (OMIM: 602285) PREDICTED: matrix meta ( 519) 358 51.3 9.1e-06
NP_057239 (OMIM: 602285) matrix metalloproteinase- ( 603) 358 51.3 1e-05
NP_001139410 (OMIM: 120353,226600,606963) intersti ( 403) 349 50.3 1.5e-05
NP_002412 (OMIM: 120353,226600,606963) interstitia ( 469) 349 50.3 1.6e-05
XP_016874798 (OMIM: 601807,611543) PREDICTED: matr ( 366) 343 49.6 2.1e-05
XP_016874797 (OMIM: 601807,611543) PREDICTED: matr ( 387) 343 49.6 2.2e-05
NP_001289438 (OMIM: 120360,259600) 72 kDa type IV ( 584) 326 47.9 0.0001
NP_001289437 (OMIM: 120360,259600) 72 kDa type IV ( 584) 326 47.9 0.0001
NP_001289439 (OMIM: 120360,259600) 72 kDa type IV ( 584) 326 47.9 0.0001
NP_001121363 (OMIM: 120360,259600) 72 kDa type IV ( 610) 326 48.0 0.00011
XP_011518521 (OMIM: 605470) PREDICTED: matrix meta ( 191) 313 46.2 0.00011
NP_004521 (OMIM: 120360,259600) 72 kDa type IV col ( 660) 326 48.0 0.00012
NP_068573 (OMIM: 605470) matrix metalloproteinase- ( 261) 313 46.3 0.00015
XP_011541138 (OMIM: 120355) PREDICTED: neutrophil ( 377) 312 46.3 0.00021
NP_071913 (OMIM: 608482) matrix metalloproteinase- ( 562) 316 46.9 0.00021
XP_011520904 (OMIM: 608482) PREDICTED: matrix meta ( 528) 310 46.2 0.00031
XP_016880552 (OMIM: 608417) PREDICTED: matrix meta ( 378) 301 45.2 0.00047
XP_016880553 (OMIM: 608417) PREDICTED: matrix meta ( 378) 301 45.2 0.00047
XP_016880551 (OMIM: 608417) PREDICTED: matrix meta ( 378) 301 45.2 0.00047
XP_011523533 (OMIM: 608417) PREDICTED: matrix meta ( 390) 301 45.2 0.00048
NP_116568 (OMIM: 608417) matrix metalloproteinase- ( 393) 301 45.2 0.00048
XP_011520906 (OMIM: 608482) PREDICTED: matrix meta ( 478) 303 45.4 0.00048
XP_011523532 (OMIM: 608417) PREDICTED: matrix meta ( 418) 301 45.2 0.0005
XP_011523531 (OMIM: 608417) PREDICTED: matrix meta ( 435) 301 45.2 0.00052
XP_011523530 (OMIM: 608417) PREDICTED: matrix meta ( 435) 301 45.2 0.00052
XP_011523528 (OMIM: 608417) PREDICTED: matrix meta ( 435) 301 45.2 0.00052
XP_011523529 (OMIM: 608417) PREDICTED: matrix meta ( 435) 301 45.2 0.00052
NP_077278 (OMIM: 608417) matrix metalloproteinase- ( 520) 301 45.3 0.0006
>>NP_671724 (OMIM: 608416,616749) matrix metalloproteina (569 aa)
initn: 4040 init1: 4040 opt: 4040 Z-score: 2328.5 bits: 440.7 E(85289): 5.9e-123
Smith-Waterman score: 4040; 100.0% identity (100.0% similar) in 569 aa overlap (1-569:1-569)
10 20 30 40 50 60
pF1KE6 MLAASIFRPTLLLCWLAAPWPTQPESLFHSRDRSDLEPSPLRQAKPIADLHAAQRFLSRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_671 MLAASIFRPTLLLCWLAAPWPTQPESLFHSRDRSDLEPSPLRQAKPIADLHAAQRFLSRY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 GWSGVWAAWGPSPEGPPETPKGAALAEAVRRFQRANALPASGELDAATLAAMNRPRCGVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_671 GWSGVWAAWGPSPEGPPETPKGAALAEAVRRFQRANALPASGELDAATLAAMNRPRCGVP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 DMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_671 DMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 LGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGRGRHLGCPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_671 LGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGRGRHLGCPR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 AFDGSGQEFAHAWRLGDIHFDDDEHFTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_671 AFDGSGQEFAHAWRLGDIHFDDDEHFTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 MQPNYIPQEPAFELDWSDRKAIQKLYGSCEGSFDTAFDWIRKERNQYGEVMVRFSTYFFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_671 MQPNYIPQEPAFELDWSDRKAIQKLYGSCEGSFDTAFDWIRKERNQYGEVMVRFSTYFFR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 NSWYWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_671 NSWYWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 SDKDQALTEDEQGKSYPKLISEGFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_671 SDKDQALTEDEQGKSYPKLISEGFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE6 VLNSYPKRITEVFPAVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVNDKDKQQNSW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_671 VLNSYPKRITEVFPAVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVNDKDKQQNSW
490 500 510 520 530 540
550 560
pF1KE6 LPANGLFPKKFISEKWFDVCDVHISTLNM
:::::::::::::::::::::::::::::
NP_671 LPANGLFPKKFISEKWFDVCDVHISTLNM
550 560
>>NP_002416 (OMIM: 185260) stromelysin-2 preproprotein [ (476 aa)
initn: 339 init1: 144 opt: 455 Z-score: 280.5 bits: 61.5 E(85289): 7e-09
Smith-Waterman score: 536; 29.6% identity (53.4% similar) in 487 aa overlap (85-541:59-474)
60 70 80 90 100 110
pF1KE6 RFLSRYGWSGVWAAWGPSPEGPPETPKGAALAEAVRRFQRANALPASGELDAATLAAMNR
... .. .:. .: ..:.::. :: .: .
NP_002 SNKDLAQQYLEKYYNLEKDVKQFRRKDSNLIVKKIQGMQKFLGLEVTGKLDTDTLEVMRK
30 40 50 60 70 80
120 130 140 150 160 170
pF1KE6 PRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAFSKR
:::::::. . : :: : :. :
NP_002 PRCGVPDV-----GHFSSFPGMPK------------------WR--------------KT
90 100 110
180 190 200 210 220 230
pF1KE6 TLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGRGR
:..:... . . ...:. . :...: ::::: : . : : :: ..:. .
NP_002 HLTYRIVNYTPDLPRDAVDS--AIEKALKVWEEVTPLTFSR--LYEGEA-DIMISFAVKE
120 130 140 150 160
240 250 260 270 280
pF1KE6 HLGCPRAFDGSGQEFAHAWR-----LGDIHFDDDEHFTPPTSDTGISLLKVAVHEIGHVL
: : .::: :. .:::. :::::::::..: .: : .:. ::.::.:: :
NP_002 H-GDFYSFDGPGHSLAHAYPPGPGLYGDIHFDDDEKWTEDAS--GTNLFLVAAHELGHSL
170 180 190 200 210 220
290 300 310 320 330
pF1KE6 GLPHTYRTGSIMQP--NYIPQEPAFELDWSDRKAIQKLYG----SCE-----------GS
:: :. : ..: : : . . :.:. .: ..::.::: : : ::
NP_002 GLFHSANTEALMYPLYNSFTELAQFRLSQDDVNGIQSLYGPPPASTEEPLVPTKSVPSGS
230 240 250 260 270 280
340 350 360 370 380
pF1KE6 -----FDTA--FDWIRKERNQYGEVMVRFSTYFFRNSWYWLYENRNNRTRYGDPIQILTG
: : :: : :..: ::.. ..: . : . .. : .
NP_002 EMPAKCDPALSFDAISTLRGEY---------LFFKDRYFWRRSHWNPEPEFH---LISAF
290 300 310 320 330
390 400 410 420 430 440
pF1KE6 WPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKSYPKLI-SEGF
::..:.. .:: .. . :: ..:.::..: ... :: .::. : . ::
NP_002 WPSLPSY-LDAAYEVNS--RDTVFIFKGNEFWAIRGNEVQA--------GYPRGIHTLGF
340 350 360 370 380
450 460 470 480 490 500
pF1KE6 PGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFPAVIPQNHPFR
: .:.: :...: ::: . . :: : . . ...:. :.. ::.: :.
NP_002 PPTIRKIDAAVSDKEKKKTYFFAADKYWRFDENSQSMEQGFPRLIADDFPGVEPKVDAVL
390 400 410 420 430 440
510 520 530 540 550 560
pF1KE6 NIDSAYYSYAYNSIFFFKGNAYWKVVNDKDKQQNSWLPANGLFPKKFISEKWFDVCDVHI
. . .: .. .: : : :: ..:. :. ::::
NP_002 QAFGFFYFFSGSSQFEFDPNA--RMVTHILKS-NSWLHC
450 460 470
pF1KE6 STLNM
>>NP_002413 (OMIM: 185250,614466) stromelysin-1 prepropr (477 aa)
initn: 334 init1: 138 opt: 438 Z-score: 270.7 bits: 59.7 E(85289): 2.4e-08
Smith-Waterman score: 525; 28.2% identity (53.3% similar) in 493 aa overlap (85-541:60-475)
60 70 80 90 100 110
pF1KE6 RFLSRYGWSGVWAAWGPSPEGPPETPKGAALAEAVRRFQRANALPASGELDAATLAAMNR
... .:..:. .: ..:.::. :: .: .
NP_002 SMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRK
30 40 50 60 70 80
120 130 140 150 160 170
pF1KE6 PRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAFSKR
:::::::. .. : : : :. :
NP_002 PRCGVPDV-----------------GHFRTFPGIP------KWR--------------KT
90 100 110
180 190 200 210 220 230
pF1KE6 TLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGRGR
:..:... . . ...:. : :...: ::::: : . : : :: ..:. .
NP_002 HLTYRIVNYTPDLPKDAVDS--AVEKALKVWEEVTPLTFSR--LYEGEA-DIMISFAVRE
120 130 140 150 160
240 250 260 270 280
pF1KE6 HLGCPRAFDGSGQEFAHAWRLG-----DIHFDDDEHFTPPTSDTGISLLKVAVHEIGHVL
: : ::: :. .:::. : : ::::::..: : :: .:. ::.::::: :
NP_002 H-GDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDT--TGTNLFLVAAHEIGHSL
170 180 190 200 210 220
290 300 310 320 330
pF1KE6 GLPHTYRTGSIMQPNY--IPQEPAFELDWSDRKAIQKLYGSCEGSFDT------------
:: :. : ..: : : . . :.:. .: ..::.::: : .:
NP_002 GLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEP
230 240 250 260 270 280
340 350 360 370 380
pF1KE6 ----------AFDWIRKERNQYGEVMVRFSTYFFRNSWYWLYENRNNRTRYGDPIQILTG
.:: . : ::... :.. .: :.. . ......
NP_002 GTPANCDPALSFDAVSTLR---GEILI------FKDRHFW----RKSLRKLEPELHLISS
290 300 310 320 330
390 400 410 420 430 440
pF1KE6 -WPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKSYPKLI-SEG
::..:. ..:: .. . .: ..:.:::.: :. .: .::. : . :
NP_002 FWPSLPS-GVDAAYEVTS--KDLVFIFKGNQFW--------AIRGNEVRAGYPRGIHTLG
340 350 360 370 380
450 460 470 480 490 500
pF1KE6 FPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFPAVIPQNHPF
:: .:.:. :.... ::: :. . :: .:: . ..::.:.: ::.. .
NP_002 FPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSK----
390 400 410 420 430
510 520 530 540 550
pF1KE6 RNIDSAYYSYAYNSIFFFKGNAYWKVVNDKDK-----QQNSWLPANGLFPKKFISEKWFD
::... ... ..:: :.. . . : ..::::
NP_002 --IDAVFEEFGF--FYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
440 450 460 470
560
pF1KE6 VCDVHISTLNM
>>NP_002420 (OMIM: 601807,611543) matrix metalloproteina (508 aa)
initn: 552 init1: 166 opt: 421 Z-score: 260.6 bits: 57.9 E(85289): 8.9e-08
Smith-Waterman score: 570; 30.2% identity (54.3% similar) in 523 aa overlap (56-556:31-469)
30 40 50 60 70 80
pF1KE6 SLFHSRDRSDLEPSPLRQAKPIADLHAAQRFLSRYGWSGVWAAWGPSPEGPPETPKGAAL
.::.::. .: .. : .
NP_002 MNCQQLWLGFLLPMTVSGRVLGLAEVAPVDYLSQYGYL-------QKPLEGSNNFKPEDI
10 20 30 40 50
90 100 110 120 130 140
pF1KE6 AEAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRS
.::.: ::.:. ::.::.:: :: : : .::::. : : .. .
NP_002 TEALRAFQEASELPVSGQLDDATRARMRQPRCGLED---------------PFNQKTLKY
60 70 80 90
150 160 170 180 190 200
pF1KE6 PRAPLSLSRRGWQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRMW
: :.: :. :. :..:.:. : : : : . ::. :
NP_002 ----LLLGR--WR--------------KKHLTFRILN--LPSTLPPHTARAALRQAFQDW
100 110 120 130
210 220 230 240 250 260
pF1KE6 SEVTPLDFREDLAAPGAAVDIKLGFGRGRHLG-CPRAFDGSGQEFAHA--WRLGDIHFDD
:.:.:: :.: : ::: ::.:.: .::. . : .::: :. .::: .::..:::.
NP_002 SNVAPLTFQEVQA--GAA-DIRLSF-HGRQSSYCSNTFDGPGRVLAHADIPELGSVHFDE
140 150 160 170 180 190
270 280 290 300 310 320
pF1KE6 DEHFTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQEPAFELDWSDRKAI
:: .: : :..: .:.::.::.::: :. . ..: : : .: :.: .: .:
NP_002 DEFWTEGTY-RGVNLRIIAAHEVGHALGLGHSRYSQALMAPVYEGYRPHFKLHPDDVAGI
200 210 220 230 240 250
330 340 350 360
pF1KE6 QKLYGSC------EGSFDTAFDWI-----------RKERNQYGEVMV--RFSTYFFRNSW
: :::. : .: . . .. .:. : .:: :....
NP_002 QALYGKKSPVIRDEEEEETELPTVPPVPTEPSPMPDPCSSELDAMMLGPRGKTYAFKGDY
260 270 280 290 300 310
370 380 390 400 410 420
pF1KE6 YWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDK
: . . : ... . : :.: :.:: :. . . . .::.:.. ::: . :
NP_002 VWTVSDSGP----GPLFRVSALWEGLPG-NLDAAVY--SPRTQWIHFFKGDKVWRYINFK
320 330 340 350 360
430 440 450 460 470 480
pF1KE6 DQALTEDEQGKSYPKLISEGFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLN
.. ..:: ... :. ::.:.: .. ...:: : . .: ..
NP_002 --------MSPGFPKKLNRVEPN----LDAALYWPLNQKVFLFKGSGYWQWDELARTDFS
370 380 390 400 410
490 500 510 520 530 540
pF1KE6 SYPKRITEVFPAVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVNDKDKQQNSWLPA
:::: : .: .: : :.: :: .:. . ..::::..::.. :. : .
NP_002 SYPKPIKGLFTGV-P-NQP-----SAAMSWQDGRVYFFKGKVYWRL--------NQQLRV
420 430 440 450
550 560
pF1KE6 NGLFPKKFISEKWFDVCDVHISTLNM
. .:.. ::..:
NP_002 EKGYPRN-ISHNWMHCRPRTIDTTPSGGNTTPSGTGITLDTTLSATETTFEY
460 470 480 490 500
>>XP_016880550 (OMIM: 608417) PREDICTED: matrix metallop (409 aa)
initn: 349 init1: 116 opt: 394 Z-score: 246.5 bits: 55.0 E(85289): 5.4e-07
Smith-Waterman score: 459; 30.1% identity (51.3% similar) in 435 aa overlap (112-539:1-385)
90 100 110 120 130 140
pF1KE6 GAALAEAVRRFQRANALPASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRAR
:.:::::: : : . ::
XP_016 MTRPRCGVTDTNS---YAAWAERISDLFAR
10 20
150 160 170 180 190
pF1KE6 SRRSPRAPLSLSRRG--WQPRGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVA
: . : ....: : : .: : ..: .: : :
XP_016 HRTKMRRKKRFAKQGNKWYK---------QHLSYRLVNW-------PEHLPEPAVRGAVR
30 40 50 60 70
200 210 220 230 240 250
pF1KE6 LAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGRGRHL-GCPRAFDGSGQEFAHAW--RLG
::..::.:. :.: : : : : ::.: : .: : : :::: : .:::. : :
XP_016 AAFQLWSNVSALEFWEA-PATGPA-DIRLTFFQGDHNDGLGNAFDGPGGALAHAFLPRRG
80 90 100 110 120
260 270 280 290 300 310
pF1KE6 DIHFDDDEHFTPPTSDTGISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQEPAFELDW
. :::.::... . : .:. : .:::::.::: :. ..: : : :.:
XP_016 EAHFDQDERWSL-SRRRGRNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKRLGRDALLSW
130 140 150 160 170 180
320 330 340 350 360 370
pF1KE6 SDRKAIQKLYGSCEGSFDTAFDWIRKERNQYGEVMVRFST-YFFRNSWYWLYENRNNRTR
.: :.:.:: : : .. . : : :: .. : . :.:..: .: .: .
XP_016 DDVLAVQSLYVSPELQYKLG-GWTVKARNPKPQARCRQQQLYIFKGSHFWEVAADGNVS-
190 200 210 220 230 240
380 390 400 410 420 430
pF1KE6 YGDPIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKS
.: . : :.: ::.: . . . . :::.:.. ::. . : :
XP_016 --EPRPLQERWVGLPP-NIEAAA--VSLNDGDFYFFKGGRCWRFRGPKPV------WG--
250 260 270 280 290
440 450 460 470 480 490
pF1KE6 YPKLISEGFPGIPSPLDTA-FYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFP
:.: : :.: :.: :. ..:: .:: . ... . .: ::. . .
XP_016 LPQLCRAG--GLPRHPDAALFFPPLRRLI-LFKGARYYVLARGGLQVEPYYPRSLQDW--
300 310 320 330 340
500 510 520 530 540 550
pF1KE6 AVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVNDKDKQQNSWLPANGLFPKKFISE
. ::.. ...: .::.::. . ::.. :. : : .
XP_016 GGIPEE-----VSGAL-PRPDGSIIFFRDDRYWRL--DQAKLQATTSGRWATELPWMGCW
350 360 370 380 390 400
560
pF1KE6 KWFDVCDVHISTLNM
XP_016 HANSGSALF
>>NP_002417 (OMIM: 601046) macrophage metalloelastase pr (470 aa)
initn: 528 init1: 116 opt: 393 Z-score: 245.1 bits: 55.0 E(85289): 6.5e-07
Smith-Waterman score: 526; 28.5% identity (54.8% similar) in 478 aa overlap (82-541:57-468)
60 70 80 90 100 110
pF1KE6 AAQRFLSRYGWSGVWAAWGPSPEGPPETPKGAALAEAVRRFQRANALPASGELDAATLAA
: . : ....:. .: ..:.::..::
NP_002 KNNVLFGERYLEKFYGLEINKLPVTKMKYSGNLMKEKIQEMQHFLGLKVTGQLDTSTLEM
30 40 50 60 70 80
120 130 140 150 160 170
pF1KE6 MNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAF
:. :::::::.. . :. : .:. :.
NP_002 MHAPRCGVPDVH-----------------HFREMPGGPV------WR-------------
90 100 110
180 190 200 210 220 230
pF1KE6 SKRTLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFG
:. ...:. . . ... : . ::..::.:::: : . : : :: . :.
NP_002 -KHYITYRI--NNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSK--INTGMA-DILVVFA
120 130 140 150 160
240 250 260 270 280
pF1KE6 RGRHLGCPRAFDGSGQEFAHAWRLG-----DIHFDDDEHFTPPTSDTGISLLKVAVHEIG
:: : : .::::.: .:::. : : :::.:: .: : . : .:. .::::::
NP_002 RGAH-GDFHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWT--THSGGTNLFLTAVHEIG
170 180 190 200 210 220
290 300 310 320 330 340
pF1KE6 HVLGLPHTYRTGSIMQPNYIPQE-PAFELDWSDRKAIQKLYGSCE-----GSFDTAFDWI
: ::: :. ..: :.: . .:.:. .: ..::.:::. . . :.. .
NP_002 HSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYGDPKENQRLPNPDNSEPAL
230 240 250 260 270 280
350 360 370 380 390
pF1KE6 RKERNQYGEVM-VRFSTYFFRNSWYWLYENRNNRTRYGDPIQILTGWPGIPTHNIDAFVH
.. : : . .::.. ..:: .. .: . : . :: .:. .:.: .
NP_002 CDPNLSFDAVTTVGNKIFFFKDRFFWLKVSERPKTSVN---LISSLWPTLPS-GIEAAYE
290 300 310 320 330
400 410 420 430 440 450
pF1KE6 IWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKSYPKLI-SEGFPGIPSPLDTAFYDR
: . :.. ..:. ..:: .. . . .::: : : :::.. . .:.: ..
NP_002 IEA--RNQVFLFKDDKYWLISNLRPEP--------NYPKSIHSFGFPNFVKKIDAAVFNP
340 350 360 370 380
460 470 480 490 500 510
pF1KE6 RQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFPAVIPQNHPFRNIDSAYYSYAYNSI
: ::: .. . .: :. . .::: ::. : .. :. ::...:: .
NP_002 RFYRTYFFVDNQYWRYDERRQMMDPGYPKLITKNFQGIGPK------IDAVFYS-KNKYY
390 400 410 420 430 440
520 530 540 550 560
pF1KE6 FFFKGNAYWKV-----VNDKDKQQNSWLPANGLFPKKFISEKWFDVCDVHISTLNM
.::.:. .. : ..:::.
NP_002 YFFQGSNQFEYDFLLQRITKTLKSNSWFGC
450 460 470
>>NP_004762 (OMIM: 604629,612529) matrix metalloproteina (483 aa)
initn: 335 init1: 94 opt: 389 Z-score: 242.6 bits: 54.5 E(85289): 8.9e-07
Smith-Waterman score: 462; 27.1% identity (51.8% similar) in 483 aa overlap (84-541:67-481)
60 70 80 90 100 110
pF1KE6 QRFLSRYGWSGVWAAWGPSPEGPPETPKGAALAEAVRRFQRANALPASGELDAATLAAMN
.. . ....: .: ..:.:: .:. ...
NP_004 NYRLAQAYLDKYYTNKEGHQIGEMVARGSNSMIRKIKELQAFFGLQVTGKLDQTTMNVIK
40 50 60 70 80 90
120 130 140 150 160 170
pF1KE6 RPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQPRGYPDGGAAQAFSK
.:::::::. : : : : :. :
NP_004 KPRCGVPDV-----------------ANYRLFPGEP------KWK--------------K
100 110
180 190 200 210 220 230
pF1KE6 RTLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAAPGAAVDIKLGFGRG
::..:. . ..: .. . : .:.. :: ..::.: . : : :: ..: :
NP_004 NTLTYRI--SKYTPSMSSVEVDKAVEMALQAWSSAVPLSFVR--INSGEA-DIMISFENG
120 130 140 150 160 170
240 250 260 270 280
pF1KE6 RHLGCPRAFDGSGQEFAHAWRLG-----DIHFDDDEHFTPPTSDTGISLLKVAVHEIGHV
: : ::: .:::. : : :::. :..: :. :..:. ::.::.::.
NP_004 DH-GDSYPFDGPRGTLAHAFAPGEGLGGDTHFDNAEKWTMGTN--GFNLFTVAAHEFGHA
180 190 200 210 220 230
290 300 310 320 330
pF1KE6 LGLPHTYRTGSIMQPNYIPQEP-AFELDWSDRKAIQKLYGSCE---GS--------FDTA
::: :. ...: :.: ..: .:.: .: :.:: ::: . :. .
NP_004 LGLAHSTDPSALMYPTYKYKNPYGFHLPKDDVKGIQALYGPRKVFLGKPTLPHAPHHKPS
240 250 260 270 280 290
340 350 360 370 380 390
pF1KE6 FDWIRKERNQYGEV-MVRFSTYFFRNSWYWLYENRNNRTRYG-DPIQILTGWPGIPTHNI
. . ... : :. .:.. .: :. . : : : : ...: . . :.
NP_004 IPDLCDSSSSFDAVTMLGKELLLFKDRIFW---RRQVHLRTGIRPSTITSSFPQLMS-NV
300 310 320 330 340
400 410 420 430 440 450
pF1KE6 DAFVHIWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKSYPKLISE-GFPGIPSPLDT
:: .. .: :::.: .:: .:. : .. :. : . ::: . .:.
NP_004 DAAYEV--AERGTAYFFKGPHYW---------ITRGFQMQGPPRTIYDFGFPRHVQQIDA
350 360 370 380 390
460 470 480 490 500 510
pF1KE6 AFYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFPAVIPQNHPFRNIDSAYYSY
: : :. . :: . ...: . .. ..::: : : .: : ::.:
NP_004 AVYLREPQKTLFFVGDEYYSYDERKRKMEKDYPKNTEEEFSGVNGQ------IDAAVELN
400 410 420 430 440 450
520 530 540 550 560
pF1KE6 AYNSIFFFKGNAYWKVVNDKDK-----QQNSWLPANGLFPKKFISEKWFDVCDVHISTLN
.: :.::.: .: ..:. ...::.
NP_004 GY--IYFFSGPKTYKYDTEKEDVVSVVKSSSWIGC
460 470 480
pF1KE6 M
>>NP_001291371 (OMIM: 120355) neutrophil collagenase iso (444 aa)
initn: 478 init1: 113 opt: 383 Z-score: 239.7 bits: 53.9 E(85289): 1.3e-06
Smith-Waterman score: 495; 29.1% identity (54.4% similar) in 478 aa overlap (71-518:21-425)
50 60 70 80 90
pF1KE6 LRQAKPIADLHAAQRFLSRYGWSGVWAAWGPSPEGPPETPKGA-ALAEAVRRFQRANALP
:: . .:. ...: ....:: .:
NP_001 MQQIPQEKSINDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLN
10 20 30 40 50
100 110 120 130 140 150
pF1KE6 ASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQP
..:. . :: :..::::::: .. :: : :.
NP_001 VTGKPNEETLDMMKKPRCGVPD-----SGGFMLTPGNPK------------------WE-
60 70 80
160 170 180 190 200 210
pF1KE6 RGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAA
. .:..:. . . ::: :. .: . ::..:: ..:: : . .
NP_001 -------------RTNLTYRI--RNYTPQLSEAEVERAIKDAFELWSVASPLIFTR--IS
90 100 110 120
220 230 240 250 260 270
pF1KE6 PGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAWRLG-----DIHFDDDEHFTPPTSDTG
: : ::...: . : : ::: . .:::.. : : ::: .: .: .....
NP_001 QGEA-DINIAFYQRDH-GDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWT--NTSAN
130 140 150 160 170 180
280 290 300 310 320
pF1KE6 ISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQEPA-FELDWSDRKAIQKLYG------
.:. ::.::.:: ::: :. :..: ::: .: . . : .: .:: .::
NP_001 YNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPI
190 200 210 220 230 240
330 340 350 360 370
pF1KE6 ---------SCEGSFDTAFDWIRKERNQYGEVMVRFSTYFFRNSWYWLYENRNNRTRYGD
:. :. .:: : : ::.. ::.. ..: . . .:... .
NP_001 QPTGPSTPKPCDPSL--TFDAITTLR---GEIL------FFKDRYFWRRHPQLQRVEM-N
250 260 270 280 290
380 390 400 410 420 430
pF1KE6 PIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKSYPK
:... ::..:: .:.: . . :: ..:.::::: ::. . ..:::
NP_001 FISLF--WPSLPT-GIQAAYE--DFDRDLIFLFKGNQYW--------ALSGYDILQGYPK
300 310 320 330 340
440 450 460 470 480 490
pF1KE6 LISE-GFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFP---
::. :::. . .:.: . : . ::: .. . .: .:. . .::: :. .::
NP_001 DISNYGFPSSVQAIDAAVFYRSK--TYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIE
350 360 370 380 390
500 510 520 530 540 550
pF1KE6 ----AVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVNDKDKQQNSWLPANGLFPKK
::. :.: :. ... : ::.. :
NP_001 SKVDAVFQQEHFFHVFSGPRY-YAFDLIAQRVTRVARGNKWLNCRYG
400 410 420 430 440
>>XP_016873260 (OMIM: 120355) PREDICTED: neutrophil coll (444 aa)
initn: 478 init1: 113 opt: 383 Z-score: 239.7 bits: 53.9 E(85289): 1.3e-06
Smith-Waterman score: 495; 29.1% identity (54.4% similar) in 478 aa overlap (71-518:21-425)
50 60 70 80 90
pF1KE6 LRQAKPIADLHAAQRFLSRYGWSGVWAAWGPSPEGPPETPKGA-ALAEAVRRFQRANALP
:: . .:. ...: ....:: .:
XP_016 MQQIPQEKSINDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLN
10 20 30 40 50
100 110 120 130 140 150
pF1KE6 ASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQP
..:. . :: :..::::::: .. :: : :.
XP_016 VTGKPNEETLDMMKKPRCGVPD-----SGGFMLTPGNPK------------------WE-
60 70 80
160 170 180 190 200 210
pF1KE6 RGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAA
. .:..:. . . ::: :. .: . ::..:: ..:: : . .
XP_016 -------------RTNLTYRI--RNYTPQLSEAEVERAIKDAFELWSVASPLIFTR--IS
90 100 110 120
220 230 240 250 260 270
pF1KE6 PGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAWRLG-----DIHFDDDEHFTPPTSDTG
: : ::...: . : : ::: . .:::.. : : ::: .: .: .....
XP_016 QGEA-DINIAFYQRDH-GDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWT--NTSAN
130 140 150 160 170 180
280 290 300 310 320
pF1KE6 ISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQEPA-FELDWSDRKAIQKLYG------
.:. ::.::.:: ::: :. :..: ::: .: . . : .: .:: .::
XP_016 YNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPI
190 200 210 220 230 240
330 340 350 360 370
pF1KE6 ---------SCEGSFDTAFDWIRKERNQYGEVMVRFSTYFFRNSWYWLYENRNNRTRYGD
:. :. .:: : : ::.. ::.. ..: . . .:... .
XP_016 QPTGPSTPKPCDPSL--TFDAITTLR---GEIL------FFKDRYFWRRHPQLQRVEM-N
250 260 270 280 290
380 390 400 410 420 430
pF1KE6 PIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKSYPK
:... ::..:: .:.: . . :: ..:.::::: ::. . ..:::
XP_016 FISLF--WPSLPT-GIQAAYE--DFDRDLIFLFKGNQYW--------ALSGYDILQGYPK
300 310 320 330 340
440 450 460 470 480 490
pF1KE6 LISE-GFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFP---
::. :::. . .:.: . : . ::: .. . .: .:. . .::: :. .::
XP_016 DISNYGFPSSVQAIDAAVFYRSK--TYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIE
350 360 370 380 390
500 510 520 530 540 550
pF1KE6 ----AVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVNDKDKQQNSWLPANGLFPKK
::. :.: :. ... : ::.. :
XP_016 SKVDAVFQQEHFFHVFSGPRY-YAFDLIAQRVTRVARGNKWLNCRYG
400 410 420 430 440
>>XP_011541137 (OMIM: 120355) PREDICTED: neutrophil coll (444 aa)
initn: 478 init1: 113 opt: 383 Z-score: 239.7 bits: 53.9 E(85289): 1.3e-06
Smith-Waterman score: 495; 29.1% identity (54.4% similar) in 478 aa overlap (71-518:21-425)
50 60 70 80 90
pF1KE6 LRQAKPIADLHAAQRFLSRYGWSGVWAAWGPSPEGPPETPKGA-ALAEAVRRFQRANALP
:: . .:. ...: ....:: .:
XP_011 MQQIPQEKSINDYLEKFYQLPSNQYQSTRKNGTNVIVEKLKEMQRFFGLN
10 20 30 40 50
100 110 120 130 140 150
pF1KE6 ASGELDAATLAAMNRPRCGVPDMRPPPPSAPPSPPGPPPRARSRRSPRAPLSLSRRGWQP
..:. . :: :..::::::: .. :: : :.
XP_011 VTGKPNEETLDMMKKPRCGVPD-----SGGFMLTPGNPK------------------WE-
60 70 80
160 170 180 190 200 210
pF1KE6 RGYPDGGAAQAFSKRTLSWRLLGEALSSQLSVADQRRIVALAFRMWSEVTPLDFREDLAA
. .:..:. . . ::: :. .: . ::..:: ..:: : . .
XP_011 -------------RTNLTYRI--RNYTPQLSEAEVERAIKDAFELWSVASPLIFTR--IS
90 100 110 120
220 230 240 250 260 270
pF1KE6 PGAAVDIKLGFGRGRHLGCPRAFDGSGQEFAHAWRLG-----DIHFDDDEHFTPPTSDTG
: : ::...: . : : ::: . .:::.. : : ::: .: .: .....
XP_011 QGEA-DINIAFYQRDH-GDNSPFDGPNGILAHAFQPGQGIGGDAHFDAEETWT--NTSAN
130 140 150 160 170 180
280 290 300 310 320
pF1KE6 ISLLKVAVHEIGHVLGLPHTYRTGSIMQPNYIPQEPA-FELDWSDRKAIQKLYG------
.:. ::.::.:: ::: :. :..: ::: .: . . : .: .:: .::
XP_011 YNLFLVAAHEFGHSLGLAHSSDPGALMYPNYAFRETSNYSLPQDDIDGIQAIYGLSSNPI
190 200 210 220 230 240
330 340 350 360 370
pF1KE6 ---------SCEGSFDTAFDWIRKERNQYGEVMVRFSTYFFRNSWYWLYENRNNRTRYGD
:. :. .:: : : ::.. ::.. ..: . . .:... .
XP_011 QPTGPSTPKPCDPSL--TFDAITTLR---GEIL------FFKDRYFWRRHPQLQRVEM-N
250 260 270 280 290
380 390 400 410 420 430
pF1KE6 PIQILTGWPGIPTHNIDAFVHIWTWKRDERYFFQGNQYWRYDSDKDQALTEDEQGKSYPK
:... ::..:: .:.: . . :: ..:.::::: ::. . ..:::
XP_011 FISLF--WPSLPT-GIQAAYE--DFDRDLIFLFKGNQYW--------ALSGYDILQGYPK
300 310 320 330 340
440 450 460 470 480 490
pF1KE6 LISE-GFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFP---
::. :::. . .:.: . : . ::: .. . .: .:. . .::: :. .::
XP_011 DISNYGFPSSVQAIDAAVFYRSK--TYFFVNDQFWRYDNQRQFMEPGYPKSISGAFPGIE
350 360 370 380 390
500 510 520 530 540 550
pF1KE6 ----AVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYWKVVNDKDKQQNSWLPANGLFPKK
::. :.: :. ... : ::.. :
XP_011 SKVDAVFQQEHFFHVFSGPRY-YAFDLIAQRVTRVARGNKWLNCRYG
400 410 420 430 440
569 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 13:27:36 2016 done: Tue Nov 8 13:27:37 2016
Total Scan time: 8.670 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]