Result of FASTA (omim) for
pFN21AE6406
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6406, 458 aa
1>>>pF1KE6406 458 - 458 aa - 458 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.1572+/-0.000426; mu= 18.0307+/- 0.026
mean_var=67.1936+/-13.044, 0's: 0 Z-trim(109.8): 51 B-trim: 0 in 0/53
Lambda= 0.156462
statistics sampled from 18008 (18055) to 18008 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.576), E-opt: 0.2 (0.212), width: 16
Scan time: 6.550
The best scores are: opt bits E(85289)
XP_005271345 (OMIM: 611339) PREDICTED: cysteine pr ( 458) 3101 709.5 4.6e-204
NP_116241 (OMIM: 611339) cysteine protease ATG4C [ ( 458) 3101 709.5 4.6e-204
NP_835739 (OMIM: 611339) cysteine protease ATG4C [ ( 458) 3101 709.5 4.6e-204
XP_011540615 (OMIM: 611339) PREDICTED: cysteine pr ( 423) 2749 630.1 3.6e-180
XP_016858090 (OMIM: 611339) PREDICTED: cysteine pr ( 418) 2478 568.9 9.2e-162
XP_016858089 (OMIM: 611339) PREDICTED: cysteine pr ( 418) 2478 568.9 9.2e-162
NP_001268433 (OMIM: 611340) cysteine protease ATG4 ( 411) 941 221.9 2.5e-57
NP_116274 (OMIM: 611340) cysteine protease ATG4D i ( 474) 941 222.0 2.8e-57
XP_006722990 (OMIM: 611340) PREDICTED: cysteine pr ( 360) 615 148.3 3.2e-35
NP_001308219 (OMIM: 300663) cysteine protease ATG4 ( 226) 348 87.9 3e-17
NP_001308217 (OMIM: 300663) cysteine protease ATG4 ( 321) 349 88.2 3.5e-17
XP_011529144 (OMIM: 300663) PREDICTED: cysteine pr ( 321) 349 88.2 3.5e-17
NP_001308216 (OMIM: 300663) cysteine protease ATG4 ( 321) 349 88.2 3.5e-17
NP_840055 (OMIM: 300663) cysteine protease ATG4A i ( 321) 349 88.2 3.5e-17
NP_443168 (OMIM: 300663) cysteine protease ATG4A i ( 398) 349 88.3 4.1e-17
XP_016859129 (OMIM: 611338) PREDICTED: cysteine pr ( 319) 329 83.7 7.9e-16
XP_005247053 (OMIM: 611338) PREDICTED: cysteine pr ( 319) 329 83.7 7.9e-16
XP_005247052 (OMIM: 611338) PREDICTED: cysteine pr ( 341) 328 83.5 9.7e-16
XP_016859128 (OMIM: 611338) PREDICTED: cysteine pr ( 341) 328 83.5 9.7e-16
NP_847896 (OMIM: 611338) cysteine protease ATG4B i ( 380) 245 64.8 4.6e-10
NP_037457 (OMIM: 611338) cysteine protease ATG4B i ( 393) 245 64.8 4.7e-10
XP_005247050 (OMIM: 611338) PREDICTED: cysteine pr ( 405) 245 64.8 4.9e-10
XP_005247049 (OMIM: 611338) PREDICTED: cysteine pr ( 415) 245 64.8 5e-10
XP_016859127 (OMIM: 611338) PREDICTED: cysteine pr ( 457) 245 64.9 5.4e-10
XP_016859126 (OMIM: 611338) PREDICTED: cysteine pr ( 479) 245 64.9 5.6e-10
NP_840054 (OMIM: 300663) cysteine protease ATG4A i ( 336) 236 62.7 1.7e-09
XP_011529143 (OMIM: 300663) PREDICTED: cysteine pr ( 340) 236 62.7 1.7e-09
NP_001308218 (OMIM: 300663) cysteine protease ATG4 ( 259) 160 45.5 0.0002
>>XP_005271345 (OMIM: 611339) PREDICTED: cysteine protea (458 aa)
initn: 3101 init1: 3101 opt: 3101 Z-score: 3784.6 bits: 709.5 E(85289): 4.6e-204
Smith-Waterman score: 3101; 100.0% identity (100.0% similar) in 458 aa overlap (1-458:1-458)
10 20 30 40 50 60
pF1KE6 MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 AESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 AQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 TIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 LRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 RTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 PLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSKEKYPLFTFVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSKEKYPLFTFVN
370 380 390 400 410 420
430 440 450
pF1KE6 GHSRDYDFTSTTTNEEDLFSEDEKKQLKRFSTEEFVLL
::::::::::::::::::::::::::::::::::::::
XP_005 GHSRDYDFTSTTTNEEDLFSEDEKKQLKRFSTEEFVLL
430 440 450
>>NP_116241 (OMIM: 611339) cysteine protease ATG4C [Homo (458 aa)
initn: 3101 init1: 3101 opt: 3101 Z-score: 3784.6 bits: 709.5 E(85289): 4.6e-204
Smith-Waterman score: 3101; 100.0% identity (100.0% similar) in 458 aa overlap (1-458:1-458)
10 20 30 40 50 60
pF1KE6 MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 AESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 AESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 AQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 AQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 TIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 TIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 LRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 LRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 RTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 RTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 PLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSKEKYPLFTFVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_116 PLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSKEKYPLFTFVN
370 380 390 400 410 420
430 440 450
pF1KE6 GHSRDYDFTSTTTNEEDLFSEDEKKQLKRFSTEEFVLL
::::::::::::::::::::::::::::::::::::::
NP_116 GHSRDYDFTSTTTNEEDLFSEDEKKQLKRFSTEEFVLL
430 440 450
>>NP_835739 (OMIM: 611339) cysteine protease ATG4C [Homo (458 aa)
initn: 3101 init1: 3101 opt: 3101 Z-score: 3784.6 bits: 709.5 E(85289): 4.6e-204
Smith-Waterman score: 3101; 100.0% identity (100.0% similar) in 458 aa overlap (1-458:1-458)
10 20 30 40 50 60
pF1KE6 MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 AESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 AESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 AQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 AQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 TIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 TIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 LRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 LRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 RTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 RTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 PLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSKEKYPLFTFVN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_835 PLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSKEKYPLFTFVN
370 380 390 400 410 420
430 440 450
pF1KE6 GHSRDYDFTSTTTNEEDLFSEDEKKQLKRFSTEEFVLL
::::::::::::::::::::::::::::::::::::::
NP_835 GHSRDYDFTSTTTNEEDLFSEDEKKQLKRFSTEEFVLL
430 440 450
>>XP_011540615 (OMIM: 611339) PREDICTED: cysteine protea (423 aa)
initn: 2749 init1: 2749 opt: 2749 Z-score: 3355.7 bits: 630.1 E(85289): 3.6e-180
Smith-Waterman score: 2749; 100.0% identity (100.0% similar) in 403 aa overlap (1-403:1-403)
10 20 30 40 50 60
pF1KE6 MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 AESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 AQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 TIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 LRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 RTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 PLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSKEKYPLFTFVN
:::::::::::::::::::::::::::::::::::::::::::
XP_011 PLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKNQIMIKAAIINIHVQDF
370 380 390 400 410 420
430 440 450
pF1KE6 GHSRDYDFTSTTTNEEDLFSEDEKKQLKRFSTEEFVLL
XP_011 MWT
>>XP_016858090 (OMIM: 611339) PREDICTED: cysteine protea (418 aa)
initn: 2468 init1: 2468 opt: 2478 Z-score: 3025.1 bits: 568.9 E(85289): 9.2e-162
Smith-Waterman score: 2722; 91.3% identity (91.3% similar) in 458 aa overlap (1-458:1-418)
10 20 30 40 50 60
pF1KE6 MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 AESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 AQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 TIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 LRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 RTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 PLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSKEKYPLFTFVN
::: :::::::::::::::::
XP_016 PLE----------------------------------------MLKFSSKEKYPLFTFVN
370 380
430 440 450
pF1KE6 GHSRDYDFTSTTTNEEDLFSEDEKKQLKRFSTEEFVLL
::::::::::::::::::::::::::::::::::::::
XP_016 GHSRDYDFTSTTTNEEDLFSEDEKKQLKRFSTEEFVLL
390 400 410
>>XP_016858089 (OMIM: 611339) PREDICTED: cysteine protea (418 aa)
initn: 2468 init1: 2468 opt: 2478 Z-score: 3025.1 bits: 568.9 E(85289): 9.2e-162
Smith-Waterman score: 2722; 91.3% identity (91.3% similar) in 458 aa overlap (1-458:1-418)
10 20 30 40 50 60
pF1KE6 MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 AESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 AQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 TIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 LRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGE
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 RTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 PLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSKEKYPLFTFVN
::: :::::::::::::::::
XP_016 PLE----------------------------------------MLKFSSKEKYPLFTFVN
370 380
430 440 450
pF1KE6 GHSRDYDFTSTTTNEEDLFSEDEKKQLKRFSTEEFVLL
::::::::::::::::::::::::::::::::::::::
XP_016 GHSRDYDFTSTTTNEEDLFSEDEKKQLKRFSTEEFVLL
390 400 410
>>NP_001268433 (OMIM: 611340) cysteine protease ATG4D is (411 aa)
initn: 1273 init1: 530 opt: 941 Z-score: 1150.2 bits: 221.9 E(85289): 2.5e-57
Smith-Waterman score: 1264; 45.1% identity (68.9% similar) in 437 aa overlap (27-458:17-411)
10 20 30 40 50 60
pF1KE6 MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFSRNSPVLLLGKCYHFKYEDEDKTLP
::.:..: ::. : . : :. :.:. :
NP_001 MQVLHLAGRCPYVSPGWVVKSRTSFSKISSIHLCGRRYRFEGE-------
10 20 30 40
70 80 90 100 110 120
pF1KE6 AESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFPQIEGSALTTDCGWGCTLRTGQMLL
:....:..::.::.:::::..:: . :. ::.:::::: ::.:::.:
NP_001 -------------GDIQRFQRDFVSRLWLTYRRDFPPLPGGCLTSDCGWGCMLRSGQMML
50 60 70 80 90
130 140 150 160 170 180
pF1KE6 AQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKKFTASFEASLSGEREFKTPTISLKE
::::.:::: : ::: ..... . : : . ... : .. : .
NP_001 AQGLLLHFLPRDWTWAEGMGL--GPPELSGSASPSRY--------HGPARWMPPRWA---
100 110 120 130
190 200 210 220 230 240
pF1KE6 TIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQLIEYGKKSGKKAGDWYGPAVVAHI
. :...: ::.:.:::.: : : ::::.:.: :..:::::::::::..::::
NP_001 -----QGAPELEQERRHRQIVSWFADHPRAPFGLHRLVELGQSSGKKAGDWYGPSLVAHI
140 150 160 170 180 190
250 260 270 280 290 300
pF1KE6 LRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRLGGE
:::::: :. ...::.::::::..:: . .. . .:. :.:.::::::::::
NP_001 LRKAVESCS--DVTRLVVYVSQDCTVYKADVA--RLVARPDPTAEWKSVVILVPVRLGGE
200 210 220 230 240
310 320 330 340 350 360
pF1KE6 RTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDVSIKDF
: :. :: .: : :.::.::::..: :: :.::: :.:.:::::: :::: ::
NP_001 TLNPVYVPCVKELLRCELCLGIMGGKPRHSLYFIGYQDDFLLYLDPHYCQPTVDVSQADF
250 260 270 280 290 300
370 380 390 400 410
pF1KE6 PLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSK-EKYPLFTFV
:::.::: ::.::.: :::::::.::: . ..:. :.:..:. :: :.::.::..
NP_001 PLESFHCTSPRKMAFAKMDPSCTVGFYAGDRKEFETLCSELTRVLSSSSATERYPMFTLA
310 320 330 340 350 360
420 430 440 450
pF1KE6 NGHSRDYDFTSTTTN--EEDLFSEDEKKQL--KRFSTEEFVLL
.::..:... . .. . : . : :: :.:.::.:
NP_001 EGHAQDHSLDDLCSQLAQPTLRLPRTGRLLRAKRPSSEDFVFL
370 380 390 400 410
>>NP_116274 (OMIM: 611340) cysteine protease ATG4D isofo (474 aa)
initn: 1302 init1: 530 opt: 941 Z-score: 1149.3 bits: 222.0 E(85289): 2.8e-57
Smith-Waterman score: 1371; 46.2% identity (70.5% similar) in 457 aa overlap (7-458:60-474)
10 20 30
pF1KE6 MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFS
:::::.:.::..::::.::.::.:..: ::
NP_116 GPRGPDPNGLGPSGASGPALGSPGAGPSEPDEVDKFKAKFLTAWNNVKYGWVVKSRTSFS
30 40 50 60 70 80
40 50 60 70 80 90
pF1KE6 RNSPVLLLGKCYHFKYEDEDKTLPAESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFP
. : . : :. :.:. : :....:..::.::.:::::..::
NP_116 KISSIHLCGRRYRFEGE--------------------GDIQRFQRDFVSRLWLTYRRDFP
90 100 110 120
100 110 120 130 140 150
pF1KE6 QIEGSALTTDCGWGCTLRTGQMLLAQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKK
. :. ::.:::::: ::.:::.:::::.:::: : ::: ..... .
NP_116 PLPGGCLTSDCGWGCMLRSGQMMLAQGLLLHFLPRDWTWAEGMGLGPPE-----------
130 140 150 160 170
160 170 180 190 200 210
pF1KE6 FTASFEASLSGEREFKTPTISLKETIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQ
. .: : : .. :. . .. . :...: ::.:.:::.: : : ::::.
NP_116 ----LSGSASPSR-YHGPARWMPPRWAQGAP--ELEQERRHRQIVSWFADHPRAPFGLHR
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE6 LIEYGKKSGKKAGDWYGPAVVAHILRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQS
:.: :..:::::::::::..:::::::::: :. ...::.::::::..:: .
NP_116 LVELGQSSGKKAGDWYGPSLVAHILRKAVESCS--DVTRLVVYVSQDCTVYKADVA--RL
240 250 260 270 280
280 290 300 310 320 330
pF1KE6 ASMTSDNADDKAVIILVPVRLGGERTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGF
.. . .:. :.:.:::::::::: : :. :: .: : :.::.::::..: :: :.
NP_116 VARPDPTAEWKSVVILVPVRLGGETLNPVYVPCVKELLRCELCLGIMGGKPRHSLYFIGY
290 300 310 320 330 340
340 350 360 370 380 390
pF1KE6 QDDSLIYMDPHYCQSFVDVSIKDFPLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKR
::: :.:.:::::: :::: :::::.::: ::.::.: :::::::.::: . ..:.
NP_116 QDDFLLYLDPHYCQPTVDVSQADFPLESFHCTSPRKMAFAKMDPSCTVGFYAGDRKEFET
350 360 370 380 390 400
400 410 420 430 440 450
pF1KE6 ASEEITKMLKFSSK-EKYPLFTFVNGHSRDYDFTSTTTN--EEDLFSEDEKKQL--KRFS
:.:..:. :: :.::.::...::..:... . .. . : . : :: :
NP_116 LCSELTRVLSSSSATERYPMFTLAEGHAQDHSLDDLCSQLAQPTLRLPRTGRLLRAKRPS
410 420 430 440 450 460
pF1KE6 TEEFVLL
.:.::.:
NP_116 SEDFVFL
470
>>XP_006722990 (OMIM: 611340) PREDICTED: cysteine protea (360 aa)
initn: 1071 init1: 530 opt: 615 Z-score: 753.3 bits: 148.3 E(85289): 3.2e-35
Smith-Waterman score: 790; 35.4% identity (52.5% similar) in 457 aa overlap (7-458:60-360)
10 20 30
pF1KE6 MEATGTDEVDKLKTKFISAWNNMKYSWVLKTKTYFS
:::::.:.::..::::.::.::.:..: ::
XP_006 GPRGPDPNGLGPSGASGPALGSPGAGPSEPDEVDKFKAKFLTAWNNVKYGWVVKSRTSFS
30 40 50 60 70 80
40 50 60 70 80 90
pF1KE6 RNSPVLLLGKCYHFKYEDEDKTLPAESGCTIEDHVIAGNVEEFRKDFISRIWLTYREEFP
. : . : :. :.:. : :....:..::.::.:::::..::
XP_006 KISSIHLCGRRYRFEGE--------------------GDIQRFQRDFVSRLWLTYRRDFP
90 100 110 120
100 110 120 130 140 150
pF1KE6 QIEGSALTTDCGWGCTLRTGQMLLAQGLILHFLGRAWTWPDALNIENSDSESWTSHTVKK
. :. ::.:::::: ::.:::.:::::.:::: :.
XP_006 PLPGGCLTSDCGWGCMLRSGQMMLAQGLLLHFLPRV------------------------
130 140 150 160
160 170 180 190 200 210
pF1KE6 FTASFEASLSGEREFKTPTISLKETIGKYSDDHEMRNEVYHRKIISWFGDSPLALFGLHQ
:. :
XP_006 ----------------------------YKAD----------------------------
220 230 240 250 260 270
pF1KE6 LIEYGKKSGKKAGDWYGPAVVAHILRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQS
::... :: ::
XP_006 --------------------VARLV------AR-PD------------------------
170
280 290 300 310 320 330
pF1KE6 ASMTSDNADDKAVIILVPVRLGGERTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGF
.:. :.:.:::::::::: : :. :: .: : :.::.::::..: :: :.
XP_006 -----PTAEWKSVVILVPVRLGGETLNPVYVPCVKELLRCELCLGIMGGKPRHSLYFIGY
180 190 200 210 220 230
340 350 360 370 380 390
pF1KE6 QDDSLIYMDPHYCQSFVDVSIKDFPLETFHCPSPKKMSFRKMDPSCTIGFYCRNVQDFKR
::: :.:.:::::: :::: :::::.::: ::.::.: :::::::.::: . ..:.
XP_006 QDDFLLYLDPHYCQPTVDVSQADFPLESFHCTSPRKMAFAKMDPSCTVGFYAGDRKEFET
240 250 260 270 280 290
400 410 420 430 440 450
pF1KE6 ASEEITKMLKFSSK-EKYPLFTFVNGHSRDYDFTSTTTN--EEDLFSEDEKKQL--KRFS
:.:..:. :: :.::.::...::..:... . .. . : . : :: :
XP_006 LCSELTRVLSSSSATERYPMFTLAEGHAQDHSLDDLCSQLAQPTLRLPRTGRLLRAKRPS
300 310 320 330 340 350
pF1KE6 TEEFVLL
.:.::.:
XP_006 SEDFVFL
360
>>NP_001308219 (OMIM: 300663) cysteine protease ATG4A is (226 aa)
initn: 328 init1: 215 opt: 348 Z-score: 430.5 bits: 87.9 E(85289): 3e-17
Smith-Waterman score: 348; 32.7% identity (62.3% similar) in 199 aa overlap (268-454:30-219)
240 250 260 270 280 290
pF1KE6 AHILRKAVEEARHPDLQGITIYVAQDCTVYNSDVIDKQSASMTSDNADDKAVIILVPVRL
.: . ..:: . .. . : ....::.::
NP_001 MDNTVVIEDIKKMCRVLPLSADTAGDRPPDSLTASNQSKGTSAYCSAWKPLLLIVPLRL
10 20 30 40 50
300 310 320 330 340 350
pF1KE6 GGERTNTDYLEFVKGILSLEYCVGIIGGKPKQSYYFAGFQDDSLIYMDPHYCQSFVDV--
: .. : :.. : ... .: .::::...::: :: : ::..::: :.:::.
NP_001 GINQINPVYVDAFKECFKMPQSLGALGGKPNNAYYFIGFLGDELIFLDPHTTQTFVDTEE
60 70 80 90 100 110
360 370 380 390 400 410
pF1KE6 --SIKDFPLETFHC-PSPKKMSFRKMDPSCTIGFYCRNVQDFKRASEEITKMLKFSSKEK
...: .:::: ::..:.. ..::: ..::.:.. .:: . : . ::.
NP_001 NGTVND---QTFHCLQSPQRMNILNLDPSVALGFFCKEEKDFDNWCSLVQKEIL---KEN
120 130 140 150 160 170
420 430 440 450
pF1KE6 YPLFTFVNGHSRDYD-FTS------TTTNEEDLFSEDEKKQLKRFSTEEFVLL
.: .:. : . :. :::. : . : .::..:. ::
NP_001 LRMFELVQKHPSHWPPFVPPAKPEVTTTGAEFI---DSTEQLEEFDLEEDFEILSV
180 190 200 210 220
458 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 12:57:56 2016 done: Tue Nov 8 12:57:57 2016
Total Scan time: 6.550 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]