Result of FASTA (omim) for
pFN21AE6402
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6402, 535 aa
1>>>pF1KE6402 535 - 535 aa - 535 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.9226+/-0.000442; mu= 14.6229+/- 0.028
mean_var=64.8295+/-13.030, 0's: 0 Z-trim(109.5): 71 B-trim: 138 in 1/50
Lambda= 0.159290
statistics sampled from 17577 (17648) to 17577 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.567), E-opt: 0.2 (0.207), width: 16
Scan time: 9.520
The best scores are: opt bits E(85289)
NP_005580 (OMIM: 603178,614105) methylmalonate-sem ( 535) 3520 818.2 0
NP_001265522 (OMIM: 603178,614105) methylmalonate- ( 522) 2791 650.7 3.1e-186
NP_001265523 (OMIM: 603178,614105) methylmalonate- ( 381) 2552 595.8 7.9e-170
XP_016876820 (OMIM: 603178,614105) PREDICTED: meth ( 381) 2552 595.8 7.9e-170
NP_000687 (OMIM: 602733) 4-trimethylaminobutyralde ( 518) 800 193.2 1.7e-48
NP_072090 (OMIM: 606467) aldehyde dehydrogenase fa ( 487) 780 188.6 3.8e-47
NP_000680 (OMIM: 100640) retinal dehydrogenase 1 [ ( 501) 775 187.4 8.7e-47
NP_000684 (OMIM: 600463,615113) aldehyde dehydroge ( 512) 768 185.8 2.7e-46
XP_011516104 (OMIM: 100670) PREDICTED: aldehyde de ( 517) 763 184.7 6.1e-46
NP_000683 (OMIM: 100670) aldehyde dehydrogenase X, ( 517) 763 184.7 6.1e-46
NP_003879 (OMIM: 603687) retinal dehydrogenase 2 i ( 518) 758 183.5 1.4e-45
NP_001193826 (OMIM: 603687) retinal dehydrogenase ( 497) 752 182.1 3.4e-45
XP_011507596 (OMIM: 602733) PREDICTED: 4-trimethyl ( 424) 715 173.6 1.1e-42
NP_000681 (OMIM: 100650,610251) aldehyde dehydroge ( 517) 716 173.9 1.1e-42
NP_001071 (OMIM: 271980,610045) succinate-semialde ( 535) 705 171.3 6.5e-42
XP_011536288 (OMIM: 613584) PREDICTED: mitochondri ( 777) 679 165.4 5.8e-40
XP_016874378 (OMIM: 613584) PREDICTED: mitochondri ( 777) 679 165.4 5.8e-40
NP_001029345 (OMIM: 613584) mitochondrial 10-formy ( 923) 679 165.4 6.8e-40
NP_733798 (OMIM: 603687) retinal dehydrogenase 2 i ( 422) 649 158.4 3.9e-38
NP_001257294 (OMIM: 600249) cytosolic 10-formyltet ( 801) 627 153.4 2.4e-36
XP_011510657 (OMIM: 600249) PREDICTED: cytosolic 1 ( 902) 627 153.5 2.6e-36
NP_036322 (OMIM: 600249) cytosolic 10-formyltetrah ( 902) 627 153.5 2.6e-36
XP_006713544 (OMIM: 600249) PREDICTED: cytosolic 1 ( 902) 627 153.5 2.6e-36
NP_001257293 (OMIM: 600249) cytosolic 10-formyltet ( 912) 627 153.5 2.7e-36
NP_001191818 (OMIM: 100650,610251) aldehyde dehydr ( 470) 610 149.5 2.1e-35
NP_001188306 (OMIM: 107323,266100) alpha-aminoadip ( 511) 558 137.5 9.1e-32
NP_001173 (OMIM: 107323,266100) alpha-aminoadipic ( 539) 558 137.6 9.6e-32
NP_739577 (OMIM: 606467) aldehyde dehydrogenase fa ( 433) 550 135.7 2.8e-31
XP_016861103 (OMIM: 600249) PREDICTED: cytosolic 1 ( 828) 462 115.5 6.3e-25
XP_016861102 (OMIM: 600249) PREDICTED: cytosolic 1 ( 838) 462 115.5 6.4e-25
NP_001280744 (OMIM: 600463,615113) aldehyde dehydr ( 405) 439 110.2 1.3e-23
XP_011541719 (OMIM: 107323,266100) PREDICTED: alph ( 404) 425 107.0 1.2e-22
XP_016864982 (OMIM: 107323,266100) PREDICTED: alph ( 404) 425 107.0 1.2e-22
NP_001189333 (OMIM: 107323,266100) alpha-aminoadip ( 475) 406 102.6 2.8e-21
NP_001154976 (OMIM: 239510,606811) delta-1-pyrroli ( 503) 342 87.9 7.9e-17
NP_003739 (OMIM: 239510,606811) delta-1-pyrroline- ( 563) 342 87.9 8.8e-17
NP_733844 (OMIM: 239510,606811) delta-1-pyrroline- ( 563) 342 87.9 8.8e-17
NP_733797 (OMIM: 603687) retinal dehydrogenase 2 i ( 480) 323 83.5 1.6e-15
NP_733936 (OMIM: 271980,610045) succinate-semialde ( 548) 287 75.3 5.5e-13
XP_011536290 (OMIM: 613584) PREDICTED: mitochondri ( 622) 283 74.4 1.2e-12
NP_001180409 (OMIM: 606467) aldehyde dehydrogenase ( 437) 256 68.1 6.2e-11
NP_001306147 (OMIM: 239510,606811) delta-1-pyrroli ( 512) 248 66.3 2.6e-10
XP_011524743 (OMIM: 613358) PREDICTED: aldehyde de ( 773) 243 65.2 8.4e-10
XP_011524744 (OMIM: 613358) PREDICTED: aldehyde de ( 773) 243 65.2 8.4e-10
NP_699160 (OMIM: 613358) aldehyde dehydrogenase fa ( 802) 243 65.2 8.7e-10
NP_001317079 (OMIM: 100660) aldehyde dehydrogenase ( 380) 210 57.6 8.2e-08
XP_011522033 (OMIM: 100660) PREDICTED: aldehyde de ( 380) 210 57.6 8.2e-08
NP_000682 (OMIM: 100660) aldehyde dehydrogenase, d ( 453) 210 57.6 9.7e-08
NP_001128639 (OMIM: 100660) aldehyde dehydrogenase ( 453) 210 57.6 9.7e-08
NP_001128640 (OMIM: 100660) aldehyde dehydrogenase ( 453) 210 57.6 9.7e-08
>>NP_005580 (OMIM: 603178,614105) methylmalonate-semiald (535 aa)
initn: 3520 init1: 3520 opt: 3520 Z-score: 4369.7 bits: 818.2 E(85289): 0
Smith-Waterman score: 3520; 100.0% identity (100.0% similar) in 535 aa overlap (1-535:1-535)
10 20 30 40 50 60
pF1KE6 MAALLAAAAVRARILQVSSKVKSSPTWYSASSFSSSVPTVKLFIGGKFVESKSDKWIDIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MAALLAAAAVRARILQVSSKVKSSPTWYSASSFSSSVPTVKLFIGGKFVESKSDKWIDIH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 NPATNEVIGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLKEIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 NPATNEVIGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLKEIA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 KLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 GIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 QHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 QHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKEN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 TLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLIT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE6 PQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE6 PVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 PVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLP
430 440 450 460 470 480
490 500 510 520 530
pF1KE6 MFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR
490 500 510 520 530
>>NP_001265522 (OMIM: 603178,614105) methylmalonate-semi (522 aa)
initn: 2787 init1: 2787 opt: 2791 Z-score: 3464.5 bits: 650.7 E(85289): 3.1e-186
Smith-Waterman score: 3406; 97.6% identity (97.6% similar) in 535 aa overlap (1-535:1-522)
10 20 30 40 50 60
pF1KE6 MAALLAAAAVRARILQVSSKVKSSPTWYSASSFSSSVPTVKLFIGGKFVESKSDKWIDIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAALLAAAAVRARILQVSSKVKSSPTWYSASSFSSSVPTVKLFIGGKFVESKSDKWIDIH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 NPATNEVIGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLKEIA
::::::::::::::::::::::::::::::::::::::::::: ::::
NP_001 NPATNEVIGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQQ-------------KEIA
70 80 90 100
130 140 150 160 170 180
pF1KE6 KLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCA
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE6 GIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHG
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE6 QHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKEN
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE6 TLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLNQLVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLIT
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE6 PQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFG
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE6 PVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLP
410 420 430 440 450 460
490 500 510 520 530
pF1KE6 MFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR
470 480 490 500 510 520
>>NP_001265523 (OMIM: 603178,614105) methylmalonate-semi (381 aa)
initn: 2552 init1: 2552 opt: 2552 Z-score: 3169.9 bits: 595.8 E(85289): 7.9e-170
Smith-Waterman score: 2552; 100.0% identity (100.0% similar) in 381 aa overlap (155-535:1-381)
130 140 150 160 170 180
pF1KE6 LEQGKTLADAEGDVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCAGIAP
::::::::::::::::::::::::::::::
NP_001 MMGETMPSITKDMDLYSYRLPLGVCAGIAP
10 20 30
190 200 210 220 230 240
pF1KE6 FNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEA
40 50 60 70 80 90
250 260 270 280 290 300
pF1KE6 VNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQ
100 110 120 130 140 150
310 320 330 340 350 360
pF1KE6 LVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLITPQAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLITPQAK
160 170 180 190 200 210
370 380 390 400 410 420
pF1KE6 ERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLV
220 230 240 250 260 270
430 440 450 460 470 480
pF1KE6 VLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLPMFSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLPMFSF
280 290 300 310 320 330
490 500 510 520 530
pF1KE6 TGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR
:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR
340 350 360 370 380
>>XP_016876820 (OMIM: 603178,614105) PREDICTED: methylma (381 aa)
initn: 2552 init1: 2552 opt: 2552 Z-score: 3169.9 bits: 595.8 E(85289): 7.9e-170
Smith-Waterman score: 2552; 100.0% identity (100.0% similar) in 381 aa overlap (155-535:1-381)
130 140 150 160 170 180
pF1KE6 LEQGKTLADAEGDVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCAGIAP
::::::::::::::::::::::::::::::
XP_016 MMGETMPSITKDMDLYSYRLPLGVCAGIAP
10 20 30
190 200 210 220 230 240
pF1KE6 FNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEA
40 50 60 70 80 90
250 260 270 280 290 300
pF1KE6 VNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQ
100 110 120 130 140 150
310 320 330 340 350 360
pF1KE6 LVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLITPQAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVGAAFGAAGQRCMALSTAVLVGEAKKWLPELVEHAKNLRVNAGDQPGADLGPLITPQAK
160 170 180 190 200 210
370 380 390 400 410 420
pF1KE6 ERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLV
220 230 240 250 260 270
430 440 450 460 470 480
pF1KE6 VLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLPMFSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLPMFSF
280 290 300 310 320 330
490 500 510 520 530
pF1KE6 TGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR
340 350 360 370 380
>>NP_000687 (OMIM: 602733) 4-trimethylaminobutyraldehyde (518 aa)
initn: 689 init1: 371 opt: 800 Z-score: 991.7 bits: 193.2 E(85289): 1.7e-48
Smith-Waterman score: 800; 30.5% identity (62.1% similar) in 515 aa overlap (10-512:3-507)
10 20 30 40 50
pF1KE6 MAALLAAAAVRARILQVSSKVKS-SPTWYSASSFSSSVPTVKL-FIGGKFVESKSDKWID
.:: . .: ..: :. .: : .. : . : . :: :: . . .
NP_000 MFLRAGLAALSPLLRSLRPSPVAAMSTGTFVVSQPLNYRGGARVEPADASGTE
10 20 30 40 50
60 70 80 90 100 110
pF1KE6 -IHNPATNEVIGRVPQATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLK
.:::..::. . . :.. :. . : :: :.. : . : ..::. ..:.:
NP_000 KAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIRERED
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE6 EIAKLITLEQGKTLADAEGDVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLG
::: . ...::.. .:. :. . : .:. .... : :: . .. :. : :::
NP_000 EIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFG-YTRREPLG
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE6 VCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNI
::.::. .:.: .: : :..:::....::: .: ...:::.. ...:.: : .:.
NP_000 VCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNV
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE6 IHGQHEAVNFICDHPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDAN
..: . .:.:.:::. .::.:: .: :.: ... : : ..:.:. ... : .
NP_000 VQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCD
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE6 KENTLNQLVGAAFGAAGQRCMALSTAVLVGEA--KKWLPELVEHAKNLRVNAGDQPGAD-
.:... . : : . :: : .: :.: . :. :.:.... :.. :: :
NP_000 MNNAVKGALMANFLTQGQVCCN-GTRVFVQKEILDKFTEEVVKQTQ--RIKIGDPLLEDT
300 310 320 330 340
360 370 380 390 400 410
pF1KE6 -LGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVK---GYENGNFVGPTIISNVKPN
.::::. ::: ... . ..::..: : : : ..: .. : ...: . .
NP_000 RMGPLINRPHLERVLGFVKVAKEQGAKVLCGG-DIYVPEDPKLKDGYYMRPCVLTNCRDD
350 360 370 380 390 400
420 430 440 450 460 470
pF1KE6 MTCYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVG
::: ::::::::. .: .: :... .:.. .: ....:: . :.. . ...:
NP_000 MTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCF
410 420 430 440 450 460
480 490 500 510 520
pF1KE6 VNVPI--PVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAV
.: :: :: : : ..: : : :. :..:.::::.
NP_000 INNYNVSPVELP---FGGYKKSGFGREN--GRVTIEYYSQLKTVCVEMGDVESAF
470 480 490 500 510
530
pF1KE6 VMPTMGR
>>NP_072090 (OMIM: 606467) aldehyde dehydrogenase family (487 aa)
initn: 651 init1: 203 opt: 780 Z-score: 967.3 bits: 188.6 E(85289): 3.8e-47
Smith-Waterman score: 780; 31.3% identity (64.9% similar) in 479 aa overlap (43-513:13-484)
20 30 40 50 60 70
pF1KE6 RILQVSSKVKSSPTWYSASSFSSSVPTVKLFIGGKFVESKSDKWIDIHNPATNEVIGRVP
:: :::. .: .:: ..:.:.:: :::
NP_072 MAGTNALLMLENFIDGKFLPCSS--YIDSYDPSTGEVYCRVP
10 20 30 40
80 90 100 110 120 130
pF1KE6 QATKAEMDAAIASCKRAFPAWADTSVLSRQQVLLRYQQLIKENLKEIAKLITLEQGKTLA
.. : :..::. . ..:::.:.. : :..:: . .:....:.:.:. . .::::::
NP_072 NSGKDEIEAAVKAAREAFPSWSSRSPQERSRVLNQVADLLEQSLEEFAQAESKDQGKTLA
50 60 70 80 90 100
140 150 160 170 180 190
pF1KE6 DAEG-DVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCAGIAPFNFPAMI
:. :. :..: . : . .: :. : :.:: . :.:.:.: ..
NP_072 LARTMDIPRSVQNFRFFASSSLHHTSECTQMDHLGCMHYTVRAPVGVAGLISPWNLPLYL
110 120 130 140 150 160
200 210 220 230 240 250
pF1KE6 PLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQHEAVNF-ICD
: . ::. ::: . :::: . .. .: :::. .:.: :..::. : :. . .
NP_072 LTWKIAPAMAAGNTVIAKPSELTSVTAWMLCKLLDKAGVPPGVVNIVFGTGPRVGEALVS
170 180 190 200 210 220
260 270 280 290 300 310
pF1KE6 HPDIKAISFVGSNKAGEYIFERGSRHGKRVQANMGAKNHGVVMPDANKENTLNQLVGAAF
::.. :::.::. ..: : . .. : :... ..:.:: .... ::: .. . : ..:
NP_072 HPEVPLISFTGSQPTAERITQLSAPHCKKLSLELGGKNPAIIFEDANLDECIPATVRSSF
230 240 250 260 270 280
320 330 340 350 360
pF1KE6 GAAGQRCMALSTAVLVGEA--KKWLPELVEHAKNLRVNAGDQPGADLGPLITPQAKERVC
. :. :. : ..: .. ...: ..:: ... .:. ..: ...: ::. :.:
NP_072 ANQGEICLCTSR-IFVQKSIYSEFLKRFVEATRKWKVGIPSDPLVSIGALISKAHLEKVR
290 300 310 320 330
370 380 390 400 410 420
pF1KE6 NLIDSGTKEGASIL----LDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEIFGPVLV
. . . :::.: .: .. ... . : :. ::.:...: . :. :::::::
NP_072 SYVKRALAEGAQIWCGEGVDKLSLPARN-QAGYFMLPTVITDIKDESCCMTEEIFGPVTC
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE6 VLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVPLPMFSF
:. .. .:.:. .:: :: .......: . ... :. .. : : .: . : . :
NP_072 VVPFDSEEEVIERANNVKYGLAATVWSSNVGRVHRVAKKLQSGLVWTNCWLIRELNL-PF
400 410 420 430 440 450
490 500 510 520 530
pF1KE6 TGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR
: .:: : . .:.. .:.:..::::
NP_072 GGMKSSGIGREG--AKDSYDFFTEIKTITVKH
460 470 480
>>NP_000680 (OMIM: 100640) retinal dehydrogenase 1 [Homo (501 aa)
initn: 554 init1: 222 opt: 775 Z-score: 960.9 bits: 187.4 E(85289): 8.7e-47
Smith-Waterman score: 775; 30.4% identity (63.9% similar) in 493 aa overlap (37-521:18-501)
10 20 30 40 50 60
pF1KE6 AAAVRARILQVSSKVKSSPTWYSASSFSSSVPTVKLFIGGKFVESKSDKWIDIHNPATNE
. .:.::.... .: : : . . ::::.:
NP_000 MSSSGTPDLPVLLTDLKIQYTKIFINNEWHDSVSGKKFPVFNPATEE
10 20 30 40
70 80 90 100 110 120
pF1KE6 VIGRVPQATKAEMDAAIASCKRAFPA---WADTSVLSRQQVLLRYQQLIKENLKEIAKLI
. .: .. : ..: :. . ..:: : .. : ..: . .::... .: .
NP_000 ELCQVEEGDKEDVDKAVKAARQAFQIGSPWRTMDASERGRLLYKLADLIERDRLLLATME
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE6 TLEQGKTLADAEGDVFRG-LQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCAGI
... :: ..: . . : ...... . .. ..:.:.: : .. :. . :.:::. :
NP_000 SMNGGKLYSNAYLNDLAGCIKTLRYCAGWADKIQGRTIP-IDGNFFTYTRHEPIGVCGQI
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE6 APFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQH
:.::: .. .: . :. :::: ..::.:..: ... .:.:....: : :..::. :
NP_000 IPWNFPLVMLIWKIGPALSCGNTVVVKPAEQTPLTALHVASLIKEAGFPPGVVNIVPGYG
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE6 EAVNF-ICDHPDIKAISFVGSNKAGEYIFER-GSRHGKRVQANMGAKNHGVVMPDANKEN
... : .: :: ..:.::...:. : : :. . ::: ..:.:. .:. ::. .:
NP_000 PTAGAAISSHMDIDKVAFTGSTEVGKLIKEAAGKSNLKRVTLELGGKSPCIVLADADLDN
230 240 250 260 270 280
310 320 330 340 350
pF1KE6 TLNQLVGAAFGAAGQRCMALSTAVLVGEA--KKWLPELVEHAKNLRVNAGDQPGADLGPL
... ..: :: :.: : ..: :. ... . ::.::. .. ::. ::
NP_000 AVEFAHHGVFYHQGQCCIAASR-IFVEESIYDEFVRRSVERAKKYILGNPLTPGVTQGPQ
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE6 ITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEI
: . ... .::.:: ::::.. : ::: :: ::..::: .: ::::
NP_000 IDKEQYDKILDLIESGKKEGAKLECGGGPWGNKGY----FVQPTVFSNVTDEMRIAKEEI
350 360 370 380 390 400
420 430 440 450 460 470
pF1KE6 FGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVP
:::: ... ..::..:. .::. :: ....:: . : . ...: : :: :
NP_000 FGPVQQIMKFKSLDDVIKRANNTFYGLSAGVFTKDIDKAITISSALQAGTVWVNC-YGVV
410 420 430 440 450 460
480 490 500 510 520 530
pF1KE6 LPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR
. : : . : :. :. :.. ::..::.: . .....
NP_000 SAQCPFGGFKMS--GNGRELGEYGFHEYTEVKTVTVKISQKNS
470 480 490 500
>>NP_000684 (OMIM: 600463,615113) aldehyde dehydrogenase (512 aa)
initn: 654 init1: 215 opt: 768 Z-score: 952.1 bits: 185.8 E(85289): 2.7e-46
Smith-Waterman score: 768; 31.8% identity (63.9% similar) in 485 aa overlap (37-513:29-504)
10 20 30 40 50 60
pF1KE6 AAAVRARILQVSSKVKSSPTWYSASSFSSSVPTVKLFIGGKFVESKSDKWIDIHNPATNE
: .:.::.... :::: : . ::.: :
NP_000 MATANGAVENGQPDRKPPALPRPIRNLEVKFTKIFINNEWHESKSGKKFATCNPSTRE
10 20 30 40 50
70 80 90 100 110 120
pF1KE6 VIGRVPQATKAEMDAAIASCKRAFP---AWADTSVLSRQQVLLRYQQLIKENLKEIAKLI
: .: .. : ..: :. . . :: : ..::: ..: . .:.... .: :
NP_000 QICEVEEGDKPDVDKAVEAAQVAFQRGSPWRRLDALSRGRLLHQLADLVERDRATLAALE
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE6 TLEQGKTLADAEGDVFRG-LQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPLGVCAGI
:.. :: . : ..: ...... . .. ..:.:.:. .. .. . :.:::..:
NP_000 TMDTGKPFLHAFFIDLEGCIRTLRYFAGWADKIQGKTIPT-DDNVVCFTRHEPIGVCGAI
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE6 APFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLNIIHGQH
.:.::: .. .: . :. ::::...::.:..: ... :..:....: : :..::. :
NP_000 TPWNFPLLMLVWKLAPALCCGNTMVLKPAEQTPLTALYLGSLIKEAGFPPGVVNIVPGFG
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE6 EAVNF-ICDHPDIKAISFVGSNKAGEYIFERGSRHG-KRVQANMGAKNHGVVMPDANKEN
.:. : .::.:. :.:.::...:. . : .:: . ::: ..:.:: .: ::. .
NP_000 PTVGAAISSHPQINKIAFTGSTEVGKLVKEAASRSNLKRVTLELGGKNPCIVCADADLDL
240 250 260 270 280 290
310 320 330 340 350
pF1KE6 TLNQLVGAAFGAAGQRCMALSTAVLVGEA--KKWLPELVEHAKNLRVNAGDQPGADLGPL
... ..: :: : : : :.: : .... . ::.::. :. . .. ::
NP_000 AVECAHQGVFFNQGQCCTAASR-VFVEEQVYSEFVRRSVEYAKKRPVGDPFDVKTEQGPQ
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE6 ITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMTCYKEEI
: . ... .::.:: ::::.. : .. :: :. ::..:.: :: ::::
NP_000 IDQKQFDKILELIESGKKEGAKLECGGSAMEDKGL----FIKPTVFSEVTDNMRIAKEEI
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE6 FGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVNVPIPVP
:::: .:. ....:.:. .:.. :: .:.:: : : : : .. : : .: .
NP_000 FGPVQPILKFKSIEEVIKRANSTDYGLTAAVFTKNLDKALKLASALESGTVWINCYNAL-
420 430 440 450 460 470
480 490 500 510 520 530
pF1KE6 LPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPTMGR
. : : . : :. :. .. ::..::.:
NP_000 YAQAPFGGFKMS--GNGRELGEYALAEYTEVKTVTIKLGDKNP
480 490 500 510
>>XP_011516104 (OMIM: 100670) PREDICTED: aldehyde dehydr (517 aa)
initn: 637 init1: 205 opt: 763 Z-score: 945.8 bits: 184.7 E(85289): 6.1e-46
Smith-Waterman score: 763; 29.5% identity (63.5% similar) in 526 aa overlap (4-521:1-517)
10 20 30 40 50 60
pF1KE6 MAALLAAAAVRARILQVSSKVKSSPTWYSASSFSSSVPTVKLFIGGKFVESKSDKWIDIH
.: : : :: . :: . . .. ..: .:::.... .. : : .
XP_011 MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTV
10 20 30 40 50
70 80 90 100 110
pF1KE6 NPATNEVIGRVPQATKAEMDAAIASCKRAF---PAWADTSVLSRQQVLLRYQQLIKENLK
::.:.::::.: .. .:..: :. . ..:: : .. : ..: : .:....
XP_011 NPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRV
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE6 EIAKLITLEQGKTLADAEG-DVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPL
.:.: ::..:: . .. . :. . ..: .. . .. :.:.: . . .. . :.
XP_011 YLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIP-MDGQHFCFTRHEPV
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE6 GVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLN
:::. : :.::: .. : . :.. ::: .:: .:..: ... ::.:....: : :..:
XP_011 GVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVN
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE6 IIHGQHEAVNF-ICDHPDIKAISFVGSNKAGEYIFER-GSRHGKRVQANMGAKNHGVVMP
:: : ... : .: :. ..:.::...:. : . :. . ::: ..:.:. ..:.
XP_011 IITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLA
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE6 DANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEA--KKWLPELVEHAKNLRVNAGDQPG
::. :....: : : :: : : : . .: :. ...: . ::.::. .:. .
XP_011 DADMEHAVEQCHEALFFNMGQCCCAGSRT-FVEESIYNEFLERTVEKAKQRKVGNPFELD
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE6 ADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMT
.. :: . . ::: . :. : ::::..: :... .:. :. ::....:. .:
XP_011 TQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGF----FIKPTVFGGVQDDMR
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE6 CYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVN
:::::::: ... . ..:... .::. :: ..:.:: . : ... ...: : ::
XP_011 IAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVN
420 430 440 450 460 470
480 490 500 510 520 530
pF1KE6 VPIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPT
. . : : . : :. :..:.. ::..::.: . ....
XP_011 T-YNIVTCHTPFGGFKES--GNGRELGEDGLKAYTEVKTVTIKVPQKNS
480 490 500 510
pF1KE6 MGR
>>NP_000683 (OMIM: 100670) aldehyde dehydrogenase X, mit (517 aa)
initn: 637 init1: 205 opt: 763 Z-score: 945.8 bits: 184.7 E(85289): 6.1e-46
Smith-Waterman score: 763; 29.5% identity (63.5% similar) in 526 aa overlap (4-521:1-517)
10 20 30 40 50 60
pF1KE6 MAALLAAAAVRARILQVSSKVKSSPTWYSASSFSSSVPTVKLFIGGKFVESKSDKWIDIH
.: : : :: . :: . . .. ..: .:::.... .. : : .
NP_000 MLRFLAPRLLSLQGRTARYSSAAALPSPILNPDIPYNQLFINNEWQDAVSKKTFPTV
10 20 30 40 50
70 80 90 100 110
pF1KE6 NPATNEVIGRVPQATKAEMDAAIASCKRAF---PAWADTSVLSRQQVLLRYQQLIKENLK
::.:.::::.: .. .:..: :. . ..:: : .. : ..: : .:....
NP_000 NPTTGEVIGHVAEGDRADVDRAVKAAREAFRLGSPWRRMDASERGRLLNRLADLVERDRV
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE6 EIAKLITLEQGKTLADAEG-DVFRGLQVVEHACSVTSLMMGETMPSITKDMDLYSYRLPL
.:.: ::..:: . .. . :. . ..: .. . .. :.:.: . . .. . :.
NP_000 YLASLETLDNGKPFQESYALDLDEVIKVYRYFAGWADKWHGKTIP-MDGQHFCFTRHEPV
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE6 GVCAGIAPFNFPAMIPLWMFPMAMVCGNTFLMKPSERVPGATMLLAKLLQDSGAPDGTLN
:::. : :.::: .. : . :.. ::: .:: .:..: ... ::.:....: : :..:
NP_000 GVCGQIIPWNFPLVMQGWKLAPALATGNTVVMKVAEQTPLSALYLASLIKEAGFPPGVVN
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE6 IIHGQHEAVNF-ICDHPDIKAISFVGSNKAGEYIFER-GSRHGKRVQANMGAKNHGVVMP
:: : ... : .: :. ..:.::...:. : . :. . ::: ..:.:. ..:.
NP_000 IITGYGPTAGAAIAQHVDVDKVAFTGSTEVGHLIQKAAGDSNLKRVTLELGGKSPSIVLA
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE6 DANKENTLNQLVGAAFGAAGQRCMALSTAVLVGEA--KKWLPELVEHAKNLRVNAGDQPG
::. :....: : : :: : : : . .: :. ...: . ::.::. .:. .
NP_000 DADMEHAVEQCHEALFFNMGQCCCAGSRT-FVEESIYNEFLERTVEKAKQRKVGNPFELD
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE6 ADLGPLITPQAKERVCNLIDSGTKEGASILLDGRKIKVKGYENGNFVGPTIISNVKPNMT
.. :: . . ::: . :. : ::::..: :... .:. :. ::....:. .:
NP_000 TQQGPQVDKEQFERVLGYIQLGQKEGAKLLCGGERFGERGF----FIKPTVFGGVQDDMR
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE6 CYKEEIFGPVLVVLETETLDEAIQIVNNNPYGNGTAIFTTNGATARKYAHLVDVGQVGVN
:::::::: ... . ..:... .::. :: ..:.:: . : ... ...: : ::
NP_000 IAKEEIFGPVQPLFKFKKIEEVVERANNTRYGLAAAVFTRDLDKAMYFTQALQAGTVWVN
420 430 440 450 460 470
480 490 500 510 520 530
pF1KE6 VPIPVPLPMFSFTGSRSSFRGDTNFYGKQGIQFYTQLKTITSQWKEEDATLSSPAVVMPT
. . : : . : :. :..:.. ::..::.: . ....
NP_000 T-YNIVTCHTPFGGFKES--GNGRELGEDGLKAYTEVKTVTIKVPQKNS
480 490 500 510
pF1KE6 MGR
535 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 12:55:34 2016 done: Tue Nov 8 12:55:36 2016
Total Scan time: 9.520 Total Display time: 0.110
Function used was FASTA [36.3.4 Apr, 2011]