Result of FASTA (omim) for
pFN21AE6392
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6392, 418 aa
1>>>pF1KE6392 418 - 418 aa - 418 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4075+/-0.000464; mu= 16.3968+/- 0.028
mean_var=72.6440+/-14.626, 0's: 0 Z-trim(109.6): 308 B-trim: 13 in 1/51
Lambda= 0.150478
statistics sampled from 17491 (17809) to 17491 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.565), E-opt: 0.2 (0.209), width: 16
Scan time: 6.800
The best scores are: opt bits E(85289)
NP_001107859 (OMIM: 611704) transmembrane protease ( 418) 2800 617.7 1.7e-176
NP_872412 (OMIM: 611704) transmembrane protease se ( 421) 2784 614.3 1.8e-175
NP_054777 (OMIM: 610399) transmembrane protease se ( 423) 1283 288.4 2.3e-77
NP_004253 (OMIM: 605369) transmembrane protease se ( 418) 1195 269.3 1.3e-71
XP_011530198 (OMIM: 610399) PREDICTED: transmembra ( 345) 1123 253.6 5.6e-67
XP_005265767 (OMIM: 605369) PREDICTED: transmembra ( 301) 930 211.7 2e-54
XP_016864340 (OMIM: 605369) PREDICTED: transmembra ( 234) 856 195.5 1.1e-49
NP_001243246 (OMIM: 605511) transmembrane protease ( 453) 693 160.3 8.8e-39
NP_076927 (OMIM: 605511) transmembrane protease se ( 454) 681 157.7 5.4e-38
NP_001275930 (OMIM: 206200,609862) transmembrane p ( 802) 660 153.3 2e-36
NP_705837 (OMIM: 206200,609862) transmembrane prot ( 811) 660 153.3 2e-36
XP_011528035 (OMIM: 602060) PREDICTED: transmembra ( 384) 640 148.8 2.2e-35
NP_115780 (OMIM: 605511) transmembrane protease se ( 327) 639 148.5 2.3e-35
XP_005261100 (OMIM: 602060) PREDICTED: transmembra ( 452) 640 148.8 2.6e-35
NP_005647 (OMIM: 602060) transmembrane protease se ( 492) 640 148.8 2.7e-35
XP_011528033 (OMIM: 602060) PREDICTED: transmembra ( 492) 640 148.8 2.7e-35
NP_001128571 (OMIM: 602060) transmembrane protease ( 529) 640 148.9 2.9e-35
NP_002763 (OMIM: 226200,606635) enteropeptidase pr (1019) 635 148.0 1e-34
XP_011527961 (OMIM: 226200,606635) PREDICTED: ente (1034) 635 148.0 1.1e-34
XP_011527960 (OMIM: 226200,606635) PREDICTED: ente (1037) 635 148.0 1.1e-34
XP_011527959 (OMIM: 226200,606635) PREDICTED: ente (1049) 635 148.0 1.1e-34
XP_011527956 (OMIM: 226200,606635) PREDICTED: ente (1064) 635 148.0 1.1e-34
XP_011527958 (OMIM: 226200,606635) PREDICTED: ente (1064) 635 148.0 1.1e-34
XP_011527957 (OMIM: 226200,606635) PREDICTED: ente (1064) 635 148.0 1.1e-34
NP_001193718 (OMIM: 610050) transmembrane protease ( 532) 627 146.0 2.1e-34
NP_001231924 (OMIM: 610050) transmembrane protease ( 563) 627 146.1 2.2e-34
NP_001070731 (OMIM: 610050) transmembrane protease ( 567) 627 146.1 2.2e-34
NP_036599 (OMIM: 609341) tryptase gamma preproprot ( 321) 615 143.3 8.3e-34
XP_005262880 (OMIM: 264900,612416) PREDICTED: coag ( 536) 612 142.8 2e-33
XP_006714200 (OMIM: 264900,612416) PREDICTED: coag ( 610) 612 142.8 2.2e-33
NP_000119 (OMIM: 264900,612416) coagulation factor ( 625) 612 142.8 2.2e-33
XP_005262878 (OMIM: 264900,612416) PREDICTED: coag ( 626) 612 142.8 2.2e-33
NP_001277025 (OMIM: 606565) transmembrane protease ( 290) 603 140.7 4.7e-33
NP_001167023 (OMIM: 606565) transmembrane protease ( 397) 603 140.8 6e-33
NP_001277023 (OMIM: 606565) transmembrane protease ( 412) 603 140.8 6.2e-33
NP_001077416 (OMIM: 606565) transmembrane protease ( 432) 603 140.8 6.4e-33
NP_001167022 (OMIM: 606565) transmembrane protease ( 435) 603 140.8 6.5e-33
NP_063947 (OMIM: 606565) transmembrane protease se ( 437) 603 140.8 6.5e-33
XP_011526284 (OMIM: 610477) PREDICTED: transmembra ( 562) 600 140.2 1.3e-32
XP_011520748 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 597 139.4 1.3e-32
XP_011520749 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 597 139.4 1.3e-32
XP_011526282 (OMIM: 610477) PREDICTED: transmembra ( 690) 600 140.3 1.5e-32
NP_892018 (OMIM: 610477) transmembrane protease se (1059) 600 140.4 2.1e-32
XP_011526280 (OMIM: 610477) PREDICTED: transmembra (1093) 600 140.4 2.2e-32
XP_005271672 (OMIM: 606565) PREDICTED: transmembra ( 454) 591 138.2 4.1e-32
XP_011541204 (OMIM: 606565) PREDICTED: transmembra ( 456) 591 138.2 4.1e-32
XP_011541203 (OMIM: 606565) PREDICTED: transmembra ( 489) 591 138.2 4.3e-32
XP_005271671 (OMIM: 606565) PREDICTED: transmembra ( 492) 591 138.2 4.4e-32
XP_005271670 (OMIM: 606565) PREDICTED: transmembra ( 494) 591 138.2 4.4e-32
NP_001275679 (OMIM: 606751) transmembrane protease ( 413) 589 137.7 5.1e-32
>>NP_001107859 (OMIM: 611704) transmembrane protease ser (418 aa)
initn: 2800 init1: 2800 opt: 2800 Z-score: 3289.9 bits: 617.7 E(85289): 1.7e-176
Smith-Waterman score: 2800; 99.8% identity (100.0% similar) in 418 aa overlap (1-418:1-418)
10 20 30 40 50 60
pF1KE6 MMYRTVGFGTRSRNLKPWMIAVLIVLSLTVVAVTIGLLVHFLVFDQKKEYYHGSFKILDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MMYRTVGFGTRSRNLKPWMIAVLIVLSLTVVAVTIGLLVHFLVFDQKKEYYHGSFKILDP
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 QINNNFGQSNTYQLKDLRETTENLVDEIFIDSAWKKNYIKNQVVRLTPEEDGVKVDVIMV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QINNNFGQSNTYQLKDLRETTENLVDEIFIDSAWKKNYIKNQVVRLTPEEDGVKVDVIMV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 FQFPSTEQRAVREKKIQSILNQKIRNLRALPINASSVQVNAMSSSTGELTVQASCGKRVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FQFPSTEQRAVREKKIQSILNQKIRNLRALPINASSVQVNAMSSSTGELTVQASCGKRVV
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 PLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKNPHQWTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKNPHQWTV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 SFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRRICLPEASASF
:::::::::::::::::::::::::::::::::::::::::::::::::.::::::::::
NP_001 SFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICLPEASASF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 QPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCAGYMEGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCAGYMEGI
310 320 330 340 350 360
370 380 390 400 410
pF1KE6 YDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWIASKTGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWIASKTGI
370 380 390 400 410
>>NP_872412 (OMIM: 611704) transmembrane protease serine (421 aa)
initn: 2257 init1: 2257 opt: 2784 Z-score: 3271.0 bits: 614.3 E(85289): 1.8e-175
Smith-Waterman score: 2784; 99.0% identity (99.3% similar) in 421 aa overlap (1-418:1-421)
10 20 30 40 50 60
pF1KE6 MMYRTVGFGTRSRNLKPWMIAVLIVLSLTVVAVTIGLLVHFLVFDQKKEYYHGSFKILDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 MMYRTVGFGTRSRNLKPWMIAVLIVLSLTVVAVTIGLLVHFLVFDQKKEYYHGSFKILDP
10 20 30 40 50 60
70 80 90 100 110
pF1KE6 QINNNFGQSNTYQLKDLRETTENLV---DEIFIDSAWKKNYIKNQVVRLTPEEDGVKVDV
::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::
NP_872 QINNNFGQSNTYQLKDLRETTENLVSQVDEIFIDSAWKKNYIKNQVVRLTPEEDGVKVDV
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE6 IMVFQFPSTEQRAVREKKIQSILNQKIRNLRALPINASSVQVNAMSSSTGELTVQASCGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 IMVFQFPSTEQRAVREKKIQSILNQKIRNLRALPINASSVQVNAMSSSTGELTVQASCGK
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE6 RVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKNPHQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 RVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKNPHQ
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE6 WTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRRICLPEAS
::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::
NP_872 WTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRQICLPEAS
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE6 ASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCAGYM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 ASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCAGYM
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE6 EGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWIASKTG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 EGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWIASKTG
370 380 390 400 410 420
pF1KE6 I
:
NP_872 I
>>NP_054777 (OMIM: 610399) transmembrane protease serine (423 aa)
initn: 1099 init1: 980 opt: 1283 Z-score: 1509.9 bits: 288.4 E(85289): 2.3e-77
Smith-Waterman score: 1283; 43.0% identity (75.4% similar) in 423 aa overlap (1-418:1-423)
10 20 30 40 50
pF1KE6 MMYRTVGFGTRSR-NLKPWMIAVLIVLSLTVVAVTIGLLVHFLVFDQKKEY-YHGSFKIL
:::: .:.: .::.:...: .:: :.:: ::: ::.. ..::: : :......
NP_054 MMYRPDVVRARKRVCWEPWVIGLVIFISLIVLAVCIGLTVHYVRYNQKKTYNYYSTLSFT
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 DPQINNNFGQSNTYQLKDLRETTENLVDEIFIDSAWKKNYIKNQVVRLTPEEDGVKVDVI
.. .::. . .. .. . :..: . : : .....:.::.... .. :: . ..
NP_054 TDKLYAEFGREASNNFTEMSQRLESMVKNAFYKSPLREEFVKSQVIKFSQQKHGVLAHML
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE6 MVFQFPSTEQRAVREKKIQSILNQKIRNLRALP-INASSVQVNAMSSSTGELTVQASCG-
.. .: :::. . .: .: .:..:... . : .. ::... .... . .. ::
NP_054 LICRFHSTEDPETVDKIVQLVLHEKLQDAVGPPKVDPHSVKIKKINKTETDSYLNHCCGT
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE6 KRVVPLNVN-RIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKNP
.: :. . ::..:. . .. ::::::::.:. :.::::::. ::::.::::: ::::
NP_054 RRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYKNP
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE6 HQWTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRRICLPE
.::.:::. :.: :::..::.:.::::. ...:::.....:: : ... ..:.:::.
NP_054 ARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPD
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE6 ASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCAG
:: :::. .. .:::::: : ::: ::.:.: .:. .:..::.:.. : : :.:::
NP_054 ASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAG
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE6 YMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWIASK
.:: :::.::::::::. : .: ::: :::::::.:.. .::::::.:: :.::.::
NP_054 SLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWITSK
370 380 390 400 410 420
pF1KE6 TGI
:::
NP_054 TGI
>>NP_004253 (OMIM: 605369) transmembrane protease serine (418 aa)
initn: 1195 init1: 869 opt: 1195 Z-score: 1406.7 bits: 269.3 E(85289): 1.3e-71
Smith-Waterman score: 1195; 40.3% identity (75.2% similar) in 419 aa overlap (2-418:1-418)
10 20 30 40 50 60
pF1KE6 MMYRTVGFGTRSRNLKPWMIAVLIVLSLTVVAVTIGLLVHFLVFDQKKEYYHGSFKILDP
::: . . :: :.:... ..: .....::::.:::.::.::::. .:..::..:.
NP_004 MYRPARVTSTSRFLNPYVVCFIVVAGVVILAVTIALLVYFLAFDQKSYFYRSSFQLLNV
10 20 30 40 50
70 80 90 100 110 120
pF1KE6 QINNNFGQSNTYQLKDLRETTENLVDEIFIDSAWKKNYIKNQVVRLTPEEDGVKVDVIMV
. :..... : . . : :.:. . : .: ....:. .:..: . .::..::.:
NP_004 EYNSQLNSPATQEYRTLSGRIESLITKTFKESNLRNQFIRAHVAKLRQDGSGVRADVVMK
60 70 80 90 100 110
130 140 150 160 170
pF1KE6 FQFPSTEQRAVREKKIQSILNQKIRNLRALPINASSVQVNAMSSSTGELTVQASCGK--R
::: ... : ...:.:.: : . : : :: :. .......... . ::
NP_004 FQFTRNNNGASMKSRIESVLRQMLNNSGNLEINPST-EITSLTDQAAANWLINECGAGPD
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE6 VVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLVTAAHCFQKYKNPHQW
.. :. .:: .:. : ...::::.::. .: :.::..::.: :..::::::.. .::..:
NP_004 LITLSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFRSNSNPRDW
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE6 TVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVTFSDDIRRICLPEASA
.. : . . : .. :: ..::..:.::..: :::.:.. . :::. ::. .::: :.
NP_004 IATSGISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQ
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE6 SFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVYGNDIKPGMFCAGYME
.. :. :...::.:: :.:.. .::...:.:::.:::. :. :.. : ::.::: .
NP_004 NIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGMLCAGVPQ
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE6 GIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYTQVTYYRNWIASKTGI
: :::.:::::::: .: . :...:::::::.:: :::::::.:: : .:: ..:::
NP_004 GGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIRQQTGI
360 370 380 390 400 410
>>XP_011530198 (OMIM: 610399) PREDICTED: transmembrane p (345 aa)
initn: 1071 init1: 980 opt: 1123 Z-score: 1323.5 bits: 253.6 E(85289): 5.6e-67
Smith-Waterman score: 1123; 44.9% identity (76.8% similar) in 345 aa overlap (77-418:1-345)
50 60 70 80 90 100
pF1KE6 KKEYYHGSFKILDPQINNNFGQSNTYQLKDLRETTENLVDEIFIDSAWKKNYIKNQVVRL
. . :..: . : : .....:.::...
XP_011 MSQRLESMVKNAFYKSPLREEFVKSQVIKF
10 20 30
110 120 130 140 150 160
pF1KE6 TPEEDGVKVDVIMVFQFPSTEQRAVREKKIQSILNQKIRNLRALP-INASSVQVNAMSSS
. .. :: . .... .: :::. . .: .: .:..:... . : .. ::... ....
XP_011 SQQKHGVLAHMLLICRFHSTEDPETVDKIVQLVLHEKLQDAVGPPKVDPHSVKIKKINKT
40 50 60 70 80 90
170 180 190 200 210 220
pF1KE6 TGELTVQASCG-KRVVPLNVN-RIASGVIAPKAAWPWQASLQYDNIHQCGATLISNTWLV
. .. :: .: :. . ::..:. . .. ::::::::.:. :.::::::. ::::
XP_011 ETDSYLNHCCGTRRSKTLGQSLRIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLV
100 110 120 130 140 150
230 240 250 260 270 280
pF1KE6 TAAHCFQKYKNPHQWTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVSSRVT
.::::: :::: .::.:::. :.: :::..::.:.::::. ...:::.....:: :
XP_011 SAAHCFTTYKNPARWTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVP
160 170 180 190 200 210
290 300 310 320 330 340
pF1KE6 FSDDIRRICLPEASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQPQVY
... ..:.:::.:: :::. .. .:::::: : ::: ::.:.: .:. .:..::.:
XP_011 YTNAVHRVCLPDASYEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAY
220 230 240 250 260 270
350 360 370 380 390 400
pF1KE6 GNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKPGVYT
.. : : :.::: .:: :::.::::::::. : .: ::: :::::::.:.. .::::::
XP_011 NDAITPRMLCAGSLEGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYT
280 290 300 310 320 330
410
pF1KE6 QVTYYRNWIASKTGI
.:: :.::.:::::
XP_011 RVTALRDWITSKTGI
340
>>XP_005265767 (OMIM: 605369) PREDICTED: transmembrane p (301 aa)
initn: 869 init1: 869 opt: 930 Z-score: 1097.9 bits: 211.7 E(85289): 2e-54
Smith-Waterman score: 930; 43.0% identity (75.5% similar) in 302 aa overlap (119-418:1-301)
90 100 110 120 130 140
pF1KE6 FIDSAWKKNYIKNQVVRLTPEEDGVKVDVIMVFQFPSTEQRAVREKKIQSILNQKIRNLR
: ::: ... : ...:.:.: : . :
XP_005 MKFQFTRNNNGASMKSRIESVLRQMLNNSG
10 20 30
150 160 170 180 190 200
pF1KE6 ALPINASSVQVNAMSSSTGELTVQASCGK--RVVPLNVNRIASGVIAPKAAWPWQASLQY
: :: :. .......... . :: .. :. .:: .:. : ...::::.::.
XP_005 NLEINPST-EITSLTDQAAANWLINECGAGPDLITLSEQRILGGTEAEEGSWPWQVSLRL
40 50 60 70 80
210 220 230 240 250 260
pF1KE6 DNIHQCGATLISNTWLVTAAHCFQKYKNPHQWTVSFGTKINPPLMKRNVRRFIIHEKYRS
.: :.::..::.: :..::::::.. .::..: .. : . . : .. :: ..::..:.:
XP_005 NNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIATSGISTTFPKLRMRVRNILIHNNYKS
90 100 110 120 130 140
270 280 290 300 310 320
pF1KE6 AAREYDIAVVQVSSRVTFSDDIRRICLPEASASFQPNLTVHITGFGALYYGGESQNDLRE
:..: :::.:.. . :::. ::. .::: :. .. :. :...::.:: :.:.. .::.
XP_005 ATHENDIALVRLENSVTFTKDIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQ
150 160 170 180 190 200
330 340 350 360 370 380
pF1KE6 ARVKIISDDVCKQPQVYGNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGI
..:.:::.:::. :. :.. : ::.::: .: :::.:::::::: .: . :...::
XP_005 GQVRIISNDVCNAPHSYNGAILSGMLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGI
210 220 230 240 250 260
390 400 410
pF1KE6 VSWGDNCGQKDKPGVYTQVTYYRNWIASKTGI
:::::.:: :::::::.:: : .:: ..:::
XP_005 VSWGDQCGLPDKPGVYTRVTAYLDWIRQQTGI
270 280 290 300
>>XP_016864340 (OMIM: 605369) PREDICTED: transmembrane p (234 aa)
initn: 856 init1: 856 opt: 856 Z-score: 1012.7 bits: 195.5 E(85289): 1.1e-49
Smith-Waterman score: 856; 48.5% identity (79.8% similar) in 233 aa overlap (186-418:2-234)
160 170 180 190 200 210
pF1KE6 SVQVNAMSSSTGELTVQASCGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGAT
:: .:. : ...::::.::. .: :.::..
XP_016 MRILGGTEAEEGSWPWQVSLRLNNAHHCGGS
10 20 30
220 230 240 250 260 270
pF1KE6 LISNTWLVTAAHCFQKYKNPHQWTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAV
::.: :..::::::.. .::..: .. : . . : .. :: ..::..:.::..: :::.
XP_016 LINNMWILTAAHCFRSNSNPRDWIATSGISTTFPKLRMRVRNILIHNNYKSATHENDIAL
40 50 60 70 80 90
280 290 300 310 320 330
pF1KE6 VQVSSRVTFSDDIRRICLPEASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDD
:.. . :::. ::. .::: :. .. :. :...::.:: :.:.. .::...:.:::.:
XP_016 VRLENSVTFTKDIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPELRQGQVRIISND
100 110 120 130 140 150
340 350 360 370 380 390
pF1KE6 VCKQPQVYGNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQ
::. :. :.. : ::.::: .: :::.:::::::: .: . :...:::::::.::
XP_016 VCNAPHSYNGAILSGMLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGL
160 170 180 190 200 210
400 410
pF1KE6 KDKPGVYTQVTYYRNWIASKTGI
:::::::.:: : .:: ..:::
XP_016 PDKPGVYTRVTAYLDWIRQQTGI
220 230
>>NP_001243246 (OMIM: 605511) transmembrane protease ser (453 aa)
initn: 670 init1: 303 opt: 693 Z-score: 817.3 bits: 160.3 E(85289): 8.8e-39
Smith-Waterman score: 693; 32.5% identity (62.0% similar) in 416 aa overlap (15-412:46-443)
10 20 30 40
pF1KE6 MMYRTVGFGTRSRNLKPWMIAVLIVLSLTVVAVTIGLLVHFLVF
:: . : :. ...: ..:..::: .::
NP_001 RSLFGLDDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIAL-ILALAIGLGIHF---
20 30 40 50 60 70
50 60 70 80 90
pF1KE6 DQKKEYY-HGSFKILDPQINNNFGQSNTYQLKD----LRETTENLVDEIFIDSAWK----
: . .: ..::: .. : : :. . .: .: .: : ..: ..::
NP_001 DCSGKYRCRSSFKCIE-LIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVFTAASWKTMCS
80 90 100 110 120 130
100 110 120 130 140
pF1KE6 ---KNYIKNQVVRLTPEEDGVKVDVIMVFQFPSTEQRAVREK--KIQSIL-NQKIRNLRA
:.. : . . :. : . : :. . ::. .:. .: ..:. :.
NP_001 DDWKGHYANVACAQLGFPSYVSSDNLRV----SSLEGQFREEFVSIDHLLPDDKVTALH-
140 150 160 170 180
150 160 170 180 190 200
pF1KE6 LPINASSVQVNAMSSSTGELTVQAS-CGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDN
:: : .: .:.: . ::.: .::..: .. . ::::::::...
NP_001 -----HSVYVREGCASGHVVTLQCTACGHRR--GYSSRIVGGNMSLLSQWPWQASLQFQG
190 200 210 220 230
210 220 230 240 250 260
pF1KE6 IHQCGATLISNTWLVTAAHCFQKYKNPHQWTVSFG--TKINPPLMKRNVRRFIIHEKYRS
: ::...:. :..::::: :..::.. : . .. : .. :.... : ::.
NP_001 YHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKP
240 250 260 270 280 290
270 280 290 300 310 320
pF1KE6 AAREYDIAVVQVSSRVTFSDDIRRICLPEASASFQPNLTVHITGFGALYYGGESQNDLRE
:::...... .::.. :. .:::.. .: . . .:.:: ::... : .
NP_001 KRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGGDASPVLNH
300 310 320 330 340 350
330 340 350 360 370 380
pF1KE6 ARVKIISDDVCKQPQVYGNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGI
: : .::. .:.. .:::. :.:.:.::::. : :.:.:::::::: .. . : :.:
NP_001 AAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQE-RRLWKLVGA
360 370 380 390 400 410
390 400 410
pF1KE6 VSWGDNCGQKDKPGVYTQVTYYRNWIASKTGI
.:.: .:.. .::::::.:: . .::
NP_001 TSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLKT
420 430 440 450
>>NP_076927 (OMIM: 605511) transmembrane protease serine (454 aa)
initn: 441 init1: 211 opt: 681 Z-score: 803.2 bits: 157.7 E(85289): 5.4e-38
Smith-Waterman score: 681; 32.4% identity (61.9% similar) in 417 aa overlap (15-412:46-444)
10 20 30 40
pF1KE6 MMYRTVGFGTRSRNLKPWMIAVLIVLSLTVVAVTIGLLVHFLVF
:: . : :. ...: ..:..::: .::
NP_076 RSLFGLDDLKISPVAPDADAVAAQILSLLPLKFFPIIVIGIIAL-ILALAIGLGIHF---
20 30 40 50 60 70
50 60 70 80 90
pF1KE6 DQKKEYY-HGSFKILDPQINNNFGQSNTYQLKD----LRETTENLVDEIFIDSAWK----
: . .: ..::: .. : : :. . .: .: .: : ..: ..::
NP_076 DCSGKYRCRSSFKCIE-LIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVFTAASWKTMCS
80 90 100 110 120 130
100 110 120 130 140
pF1KE6 ---KNYIKNQVVRLTPEEDGVKVDVIMVFQFPSTEQRAVREK--KIQSIL-NQKIRNLRA
:.. : . . :. : . : :. . ::. .:. .: ..:. :.
NP_076 DDWKGHYANVACAQLGFPSYVSSDNLRV----SSLEGQFREEFVSIDHLLPDDKVTALH-
140 150 160 170 180
150 160 170 180 190 200
pF1KE6 LPINASSVQVNAMSSSTGELTVQAS-CGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDN
:: : .: .:.: . ::.: .::..: .. . ::::::::...
NP_076 -----HSVYVREGCASGHVVTLQCTACGHRR--GYSSRIVGGNMSLLSQWPWQASLQFQG
190 200 210 220 230
210 220 230 240 250 260
pF1KE6 IHQCGATLISNTWLVTAAHCFQKYKNPHQWTVSFG--TKINPPLMKRNVRRFIIHEKYRS
: ::...:. :..::::: :..::.. : . .. : .. :.... : ::.
NP_076 YHLCGGSVITPLWIITAAHCVYDLYLPKSWTIQVGLVSLLDNPAPSHLVEKIVYHSKYKP
240 250 260 270 280 290
270 280 290 300 310 320
pF1KE6 AAREYDIAVVQVSSRVTFSDDIRRICLPEASASFQPNLTVHITGFGALYYG-GESQNDLR
:::...... .::.. :. .:::.. .: . . .:.:: : :... :
NP_076 KRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLN
300 310 320 330 340 350
330 340 350 360 370 380
pF1KE6 EARVKIISDDVCKQPQVYGNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIG
.: : .::. .:.. .:::. :.:.:.::::. : :.:.:::::::: .. . : :.:
NP_076 HAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQE-RRLWKLVG
360 370 380 390 400 410
390 400 410
pF1KE6 IVSWGDNCGQKDKPGVYTQVTYYRNWIASKTGI
.:.: .:.. .::::::.:: . .::
NP_076 ATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLKT
420 430 440 450
>>NP_001275930 (OMIM: 206200,609862) transmembrane prote (802 aa)
initn: 634 init1: 279 opt: 660 Z-score: 774.9 bits: 153.3 E(85289): 2e-36
Smith-Waterman score: 660; 42.1% identity (70.6% similar) in 235 aa overlap (185-412:566-797)
160 170 180 190 200 210
pF1KE6 SSVQVNAMSSSTGELTVQASCGKRVVPLNVNRIASGVIAPKAAWPWQASLQYDNIHQCGA
.::..:... .. :::::::: . : ::.
NP_001 KKPNPQCDGRPDCRDGSDEEHCDCGLQGPSSRIVGGAVSSEGEWPWQASLQVRGRHICGG
540 550 560 570 580 590
220 230 240 250 260
pF1KE6 TLISNTWLVTAAHCFQK--YKNPHQWTVSFGTKI--N---PPLMKRNVRRFIIHEKYRSA
.::.. :..:::::::. . . ::: .: :. : : .. .: :...: ..
NP_001 ALIADRWVITAAHCFQEDSMASTVLWTVFLG-KVWQNSRWPGEVSFKVSRLLLHPYHEED
600 610 620 630 640 650
270 280 290 300 310 320
pF1KE6 AREYDIAVVQVSSRVTFSDDIRRICLPEASASFQPNLTVHITGFGALYYGGESQNDLREA
...::.:..:.. :. : .: .::: : :.:.: :::.::: :: .: :...
NP_001 SHDYDVALLQLDHPVVRSAAVRPVCLPARSHFFEPGLHCWITGWGALREGGPISNALQKV
660 670 680 690 700 710
330 340 350 360 370 380
pF1KE6 RVKIISDDVCKQPQVYGNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIV
:..: .:.:. .:: .. : :.:::: .: :::.:::::::: . :. :.: :.:
NP_001 DVQLIPQDLCS--EVYRYQVTPRMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLV
720 730 740 750 760 770
390 400 410
pF1KE6 SWGDNCGQKDKPGVYTQVTYYRNWIASKTGI
::: .::. . ::::..: .::
NP_001 SWGLGCGRPNYFGVYTRITGVISWIQQVVT
780 790 800
418 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 12:51:52 2016 done: Tue Nov 8 12:51:53 2016
Total Scan time: 6.800 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]