Result of FASTA (omim) for
pFN21AE6379
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6379, 327 aa
1>>>pF1KE6379 327 - 327 aa - 327 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.0617+/-0.000449; mu= 16.8024+/- 0.028
mean_var=59.9467+/-11.670, 0's: 0 Z-trim(108.8): 25 B-trim: 406 in 1/53
Lambda= 0.165650
statistics sampled from 16883 (16895) to 16883 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.562), E-opt: 0.2 (0.198), width: 16
Scan time: 3.780
The best scores are: opt bits E(85289)
NP_004887 (OMIM: 605506) vacuolar protein sorting- ( 327) 2141 520.5 1.9e-147
NP_001305874 (OMIM: 605506) vacuolar protein sorti ( 310) 1802 439.5 4.3e-123
NP_001305873 (OMIM: 605506) vacuolar protein sorti ( 320) 1796 438.1 1.2e-122
NP_001030337 (OMIM: 605506) vacuolar protein sorti ( 251) 1582 386.9 2.4e-107
NP_443107 (OMIM: 610027) vacuolar protein sorting- ( 336) 1540 376.9 3.3e-104
NP_001305875 (OMIM: 605506) vacuolar protein sorti ( 216) 1404 344.3 1.4e-94
XP_011540867 (OMIM: 610027) PREDICTED: vacuolar pr ( 229) 892 221.9 9.8e-58
NP_001317951 (OMIM: 605298) Down syndrome critical ( 270) 165 48.2 2.3e-05
NP_001317947 (OMIM: 605298) Down syndrome critical ( 172) 126 38.8 0.0099
>>NP_004887 (OMIM: 605506) vacuolar protein sorting-asso (327 aa)
initn: 2141 init1: 2141 opt: 2141 Z-score: 2768.3 bits: 520.5 E(85289): 1.9e-147
Smith-Waterman score: 2141; 100.0% identity (100.0% similar) in 327 aa overlap (1-327:1-327)
10 20 30 40 50 60
pF1KE6 MSFLGGFFGPICEIDIVLNDGETRKMAEMKTEDGKVEKHYLFYDGESVSGKVNLAFKQPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MSFLGGFFGPICEIDIVLNDGETRKMAEMKTEDGKVEKHYLFYDGESVSGKVNLAFKQPG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 KRLEHQGIRIEFVGQIELFNDKSNTHEFVNLVKELALPGELTQSRSYDFEFMQVEKPYES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KRLEHQGIRIEFVGQIELFNDKSNTHEFVNLVKELALPGELTQSRSYDFEFMQVEKPYES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 YIGANVRLRYFLKVTIVRRLTDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 YIGANVRLRYFLKVTIVRRLTDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 NKSKYHLKDVIVGKIYFLLVRIKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 NKSKYHLKDVIVGKIYFLLVRIKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 VKGESIPIRLFLAGYDPTPTMRDVNKKFSVRYFLNLVLVDEEDRRYFKQQEIILWRKAPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 VKGESIPIRLFLAGYDPTPTMRDVNKKFSVRYFLNLVLVDEEDRRYFKQQEIILWRKAPE
250 260 270 280 290 300
310 320
pF1KE6 KLRKQRTNFHQRFESPESQASAEQPEM
:::::::::::::::::::::::::::
NP_004 KLRKQRTNFHQRFESPESQASAEQPEM
310 320
>>NP_001305874 (OMIM: 605506) vacuolar protein sorting-a (310 aa)
initn: 1802 init1: 1802 opt: 1802 Z-score: 2330.8 bits: 439.5 E(85289): 4.3e-123
Smith-Waterman score: 1802; 100.0% identity (100.0% similar) in 277 aa overlap (51-327:34-310)
30 40 50 60 70 80
pF1KE6 GETRKMAEMKTEDGKVEKHYLFYDGESVSGKVNLAFKQPGKRLEHQGIRIEFVGQIELFN
::::::::::::::::::::::::::::::
NP_001 NPFQERYSVEDLSTFGMCLCMVRYVYDAFYKVNLAFKQPGKRLEHQGIRIEFVGQIELFN
10 20 30 40 50 60
90 100 110 120 130 140
pF1KE6 DKSNTHEFVNLVKELALPGELTQSRSYDFEFMQVEKPYESYIGANVRLRYFLKVTIVRRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DKSNTHEFVNLVKELALPGELTQSRSYDFEFMQVEKPYESYIGANVRLRYFLKVTIVRRL
70 80 90 100 110 120
150 160 170 180 190 200
pF1KE6 TDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLV
130 140 150 160 170 180
210 220 230 240 250 260
pF1KE6 RIKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAPVKGESIPIRLFLAGYDPTPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RIKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAPVKGESIPIRLFLAGYDPTPT
190 200 210 220 230 240
270 280 290 300 310 320
pF1KE6 MRDVNKKFSVRYFLNLVLVDEEDRRYFKQQEIILWRKAPEKLRKQRTNFHQRFESPESQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MRDVNKKFSVRYFLNLVLVDEEDRRYFKQQEIILWRKAPEKLRKQRTNFHQRFESPESQA
250 260 270 280 290 300
pF1KE6 SAEQPEM
:::::::
NP_001 SAEQPEM
310
>>NP_001305873 (OMIM: 605506) vacuolar protein sorting-a (320 aa)
initn: 1796 init1: 1796 opt: 1796 Z-score: 2322.9 bits: 438.1 E(85289): 1.2e-122
Smith-Waterman score: 1796; 100.0% identity (100.0% similar) in 276 aa overlap (52-327:45-320)
30 40 50 60 70 80
pF1KE6 ETRKMAEMKTEDGKVEKHYLFYDGESVSGKVNLAFKQPGKRLEHQGIRIEFVGQIELFND
::::::::::::::::::::::::::::::
NP_001 LSTFGMCLCMVRYVYDAFYKVSLFSPFLYPVNLAFKQPGKRLEHQGIRIEFVGQIELFND
20 30 40 50 60 70
90 100 110 120 130 140
pF1KE6 KSNTHEFVNLVKELALPGELTQSRSYDFEFMQVEKPYESYIGANVRLRYFLKVTIVRRLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KSNTHEFVNLVKELALPGELTQSRSYDFEFMQVEKPYESYIGANVRLRYFLKVTIVRRLT
80 90 100 110 120 130
150 160 170 180 190 200
pF1KE6 DLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVR
140 150 160 170 180 190
210 220 230 240 250 260
pF1KE6 IKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAPVKGESIPIRLFLAGYDPTPTM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAPVKGESIPIRLFLAGYDPTPTM
200 210 220 230 240 250
270 280 290 300 310 320
pF1KE6 RDVNKKFSVRYFLNLVLVDEEDRRYFKQQEIILWRKAPEKLRKQRTNFHQRFESPESQAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDVNKKFSVRYFLNLVLVDEEDRRYFKQQEIILWRKAPEKLRKQRTNFHQRFESPESQAS
260 270 280 290 300 310
pF1KE6 AEQPEM
::::::
NP_001 AEQPEM
320
>>NP_001030337 (OMIM: 605506) vacuolar protein sorting-a (251 aa)
initn: 1582 init1: 1582 opt: 1582 Z-score: 2048.1 bits: 386.9 E(85289): 2.4e-107
Smith-Waterman score: 1582; 99.2% identity (100.0% similar) in 245 aa overlap (1-245:1-245)
10 20 30 40 50 60
pF1KE6 MSFLGGFFGPICEIDIVLNDGETRKMAEMKTEDGKVEKHYLFYDGESVSGKVNLAFKQPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSFLGGFFGPICEIDIVLNDGETRKMAEMKTEDGKVEKHYLFYDGESVSGKVNLAFKQPG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 KRLEHQGIRIEFVGQIELFNDKSNTHEFVNLVKELALPGELTQSRSYDFEFMQVEKPYES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KRLEHQGIRIEFVGQIELFNDKSNTHEFVNLVKELALPGELTQSRSYDFEFMQVEKPYES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 YIGANVRLRYFLKVTIVRRLTDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YIGANVRLRYFLKVTIVRRLTDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 NKSKYHLKDVIVGKIYFLLVRIKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NKSKYHLKDVIVGKIYFLLVRIKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 VKGESIPIRLFLAGYDPTPTMRDVNKKFSVRYFLNLVLVDEEDRRYFKQQEIILWRKAPE
:::..
NP_001 VKGDNFMEKSS
250
>>NP_443107 (OMIM: 610027) vacuolar protein sorting-asso (336 aa)
initn: 1527 init1: 1504 opt: 1540 Z-score: 1991.9 bits: 376.9 E(85289): 3.3e-104
Smith-Waterman score: 1540; 69.8% identity (89.3% similar) in 328 aa overlap (1-325:1-326)
10 20 30 40 50 60
pF1KE6 MSFLGGFFGPICEIDIVLNDGETRKMAEMKTEDGKVEKHYLFYDGESVSGKVNLAFKQPG
:::.: :: :..:.:::.:.:: :: :::::: ::..::::::.:::::.::.:.:.
NP_443 MSFFG--FGQSVEVEILLNDAESRKRAEHKTEDGKKEKYFLFYDGETVSGKVSLALKNPN
10 20 30 40 50
70 80 90 100 110 120
pF1KE6 KRLEHQGIRIEFVGQIELFNDKSNTHEFVNLVKELALPGELTQSRSYDFEFMQVEKPYES
::::::::.:::.:::::. :..: ::::.:::.:: :::.:::...:::: .:::::::
NP_443 KRLEHQGIKIEFIGQIELYYDRGNHHEFVSLVKDLARPGEITQSQAFDFEFTHVEKPYES
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE6 YIGANVRLRYFLKVTIVRRLTDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEY
: : ::.:::::..:: :::.:.:::.:..:: :.:::..:.::::::::::::::::::
NP_443 YTGQNVKLRYFLRATISRRLNDVVKEMDIVVHTLSTYPELNSSIKMEVGIEDCLHIEFEY
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE6 NKSKYHLKDVIVGKIYFLLVRIKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAP
::::::::::::::::::::::::.:::...::.: :: ::.. :..::::::::::::
NP_443 NKSKYHLKDVIVGKIYFLLVRIKIKHMEIDIIKRETTGTGPNVYHENDTIAKYEIMDGAP
180 190 200 210 220 230
250 260 270 280 290
pF1KE6 VKGESIPIRLFLAGYDPTPTMRDVNKKFSVRYFLNLVLVDEEDRRYFKQQEIILWRKAP-
:.:::::::::::::. ::::::.::::::::.:::::.:::.::::::::..::::.
NP_443 VRGESIPIRLFLAGYELTPTMRDINKKFSVRYYLNLVLIDEEERRYFKQQEVVLWRKGDI
240 250 260 270 280 290
300 310 320
pF1KE6 --EKLRKQRTNFHQRFESPESQASAEQPEM
... .: . ::::. : . .. :
NP_443 VRKSMSHQAAIASQRFEGTTSLGEVRTPSQLSDNNCRQ
300 310 320 330
>>NP_001305875 (OMIM: 605506) vacuolar protein sorting-a (216 aa)
initn: 1404 init1: 1404 opt: 1404 Z-score: 1819.1 bits: 344.3 E(85289): 1.4e-94
Smith-Waterman score: 1404; 100.0% identity (100.0% similar) in 216 aa overlap (112-327:1-216)
90 100 110 120 130 140
pF1KE6 KSNTHEFVNLVKELALPGELTQSRSYDFEFMQVEKPYESYIGANVRLRYFLKVTIVRRLT
::::::::::::::::::::::::::::::
NP_001 MQVEKPYESYIGANVRLRYFLKVTIVRRLT
10 20 30
150 160 170 180 190 200
pF1KE6 DLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVR
40 50 60 70 80 90
210 220 230 240 250 260
pF1KE6 IKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAPVKGESIPIRLFLAGYDPTPTM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAPVKGESIPIRLFLAGYDPTPTM
100 110 120 130 140 150
270 280 290 300 310 320
pF1KE6 RDVNKKFSVRYFLNLVLVDEEDRRYFKQQEIILWRKAPEKLRKQRTNFHQRFESPESQAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RDVNKKFSVRYFLNLVLVDEEDRRYFKQQEIILWRKAPEKLRKQRTNFHQRFESPESQAS
160 170 180 190 200 210
pF1KE6 AEQPEM
::::::
NP_001 AEQPEM
>>XP_011540867 (OMIM: 610027) PREDICTED: vacuolar protei (229 aa)
initn: 894 init1: 873 opt: 892 Z-score: 1157.5 bits: 221.9 E(85289): 9.8e-58
Smith-Waterman score: 892; 63.0% identity (85.2% similar) in 216 aa overlap (1-214:1-213)
10 20 30 40 50 60
pF1KE6 MSFLGGFFGPICEIDIVLNDGETRKMAEMKTEDGKVEKHYLFYDGESVSGKVNLAFKQPG
:::.: :: :..:.:::.:.:: :: :::::: ::..::::::.:::::.::.:.:.
XP_011 MSFFG--FGQSVEVEILLNDAESRKRAEHKTEDGKKEKYFLFYDGETVSGKVSLALKNPN
10 20 30 40 50
70 80 90 100 110 120
pF1KE6 KRLEHQGIRIEFVGQIELFNDKSNTHEFVNLVKELALPGELTQSRSYDFEFMQVEKPYES
::::::::.:::.:::::. :..: ::::.:::.:: :::.:::...:::: .:::::::
XP_011 KRLEHQGIKIEFIGQIELYYDRGNHHEFVSLVKDLARPGEITQSQAFDFEFTHVEKPYES
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE6 YIGANVRLRYFLKVTIVRRLTDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEY
: : ::.:::::..:: :::.:.:::.:..:: :.:::..:.::::::::::::::::::
XP_011 YTGQNVKLRYFLRATISRRLNDVVKEMDIVVHTLSTYPELNSSIKMEVGIEDCLHIEFEY
120 130 140 150 160 170
190 200 210 220 230
pF1KE6 NKSKYHLKDVIVGKI--YFLLVRIKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDG
:::.. ... : : .. .. :. :: :.
XP_011 NKSNFSCFPLLLRTISEYHSIIMCSL-HLCLQKSKRRNQILAMICCFLPELK
180 190 200 210 220
240 250 260 270 280 290
pF1KE6 APVKGESIPIRLFLAGYDPTPTMRDVNKKFSVRYFLNLVLVDEEDRRYFKQQEIILWRKA
>>NP_001317951 (OMIM: 605298) Down syndrome critical reg (270 aa)
initn: 172 init1: 100 opt: 165 Z-score: 217.4 bits: 48.2 E(85289): 2.3e-05
Smith-Waterman score: 169; 21.5% identity (55.9% similar) in 270 aa overlap (33-283:6-256)
10 20 30 40 50 60
pF1KE6 FLGGFFGPICEIDIVLNDGETRKMAEMKTEDGKVEK-HYLFYDGESVSGKVNLAFKQPGK
: :... . ... :: .:: : .. :.
NP_001 MGTALDIKIKRANKVYHAGEVLSGVVVISSKDS--
10 20 30
70 80 90 100
pF1KE6 RLEHQGIRIEF------------VGQIELFNDKSNTHEFVNLVKELALPGELTQSRS-YD
..:::. . . :: .: : .. . ...: . :.. ::.. ....
NP_001 -VQHQGVSLTMEGTVNLQLSAKSVGVFEAFYNSVKPIQIINSTIEMVKPGKFPSGKTEIP
40 50 60 70 80 90
110 120 130 140 150 160
pF1KE6 FEF---MQVEKP-YESYIGANVRLRYFLKVTIVR-RLTDLVKEYDLIVHQLATYPDVNNS
::: .. .: ::.: :. :... . ..: . :. . :.. ..
NP_001 FEFPLHLKGNKVLYETYHGV------FVNIQPQKGKFTP--SPVDFTIT-----PETLQN
100 110 120 130
170 180 190 200 210 220
pF1KE6 IKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVRIKIQHMELQLIKKEITGIGPST
.: .. . : .. . :... . . ..:.. . :. .::::.. : : . .
NP_001 VKERALLPKFL-LRGHLNSTNCVITQPLTGELVVESSEAAIRSVELQLVRVETCGCAEGY
140 150 160 170 180 190
230 240 250 260 270 280
pF1KE6 TTETETIAKYEIMDGAPVKGESIPIRLFLAGYDPTPTMRDVNKKFSVRYFLNLVLVDEED
. .. : . .: :: .: :.:: . . ::.. .: :.:.. .:.:.. . :
NP_001 ARDATEIQNIQIADGDVCRGLSVPIYMVFPRLFTCPTLETTN--FKVEFEVNIVVLLHPD
200 210 220 230 240 250
290 300 310 320
pF1KE6 RRYFKQQEIILWRKAPEKLRKQRTNFHQRFESPESQASAEQPEM
NP_001 HLITENFPLKLCRI
260 270
>>NP_001317947 (OMIM: 605298) Down syndrome critical reg (172 aa)
initn: 122 init1: 100 opt: 126 Z-score: 170.0 bits: 38.8 E(85289): 0.0099
Smith-Waterman score: 126; 22.2% identity (59.5% similar) in 126 aa overlap (158-283:36-158)
130 140 150 160 170 180
pF1KE6 LRYFLKVTIVRRLTDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEYNKSKYHL
:.. ...: .. . : .. . :... .
NP_001 DIKIKRANKVYHAGPQKGKFTPSPVDFTITPETLQNVKERALLPKFL-LRGHLNSTNCVI
10 20 30 40 50 60
190 200 210 220 230 240
pF1KE6 KDVIVGKIYFLLVRIKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAPVKGESIP
. ..:.. . :. .::::.. : : . . . .. : . .: :: .: :.:
NP_001 TQPLTGELVVESSEAAIRSVELQLVRVETCGCAEGYARDATEIQNIQIADGDVCRGLSVP
70 80 90 100 110 120
250 260 270 280 290 300
pF1KE6 IRLFLAGYDPTPTMRDVNKKFSVRYFLNLVLVDEEDRRYFKQQEIILWRKAPEKLRKQRT
: . . ::.. .: :.:.. .:.:.. . :
NP_001 IYMVFPRLFTCPTLETTN--FKVEFEVNIVVLLHPDHLITENFPLKLCRI
130 140 150 160 170
310 320
pF1KE6 NFHQRFESPESQASAEQPEM
327 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 12:44:16 2016 done: Tue Nov 8 12:44:17 2016
Total Scan time: 3.780 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]