Result of FASTA (omim) for
pFN21AE6370
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6370, 326 aa
1>>>pF1KE6370 326 - 326 aa - 326 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.7603+/-0.000304; mu= 19.7414+/- 0.019
mean_var=69.5904+/-13.971, 0's: 0 Z-trim(117.6): 316 B-trim: 0 in 0/57
Lambda= 0.153744
statistics sampled from 29520 (29839) to 29520 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.709), E-opt: 0.2 (0.35), width: 16
Scan time: 6.220
The best scores are: opt bits E(85289)
NP_071402 (OMIM: 609343) brain-specific serine pro ( 317) 652 153.2 6.9e-37
XP_005255530 (OMIM: 609343) PREDICTED: brain-speci ( 317) 652 153.2 6.9e-37
NP_036599 (OMIM: 609341) tryptase gamma preproprot ( 321) 651 152.9 8.1e-37
NP_001275679 (OMIM: 606751) transmembrane protease ( 413) 652 153.3 8.4e-37
NP_001275680 (OMIM: 606751) transmembrane protease ( 448) 652 153.3 8.9e-37
NP_110397 (OMIM: 606751) transmembrane protease se ( 457) 652 153.3 9e-37
XP_011520749 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 639 150.3 5.4e-36
XP_011520748 (OMIM: 609341) PREDICTED: tryptase ga ( 346) 639 150.3 5.4e-36
NP_001193718 (OMIM: 610050) transmembrane protease ( 532) 638 150.3 8.7e-36
NP_001231924 (OMIM: 610050) transmembrane protease ( 563) 638 150.3 9e-36
NP_001070731 (OMIM: 610050) transmembrane protease ( 567) 638 150.3 9.1e-36
XP_005262880 (OMIM: 264900,612416) PREDICTED: coag ( 536) 636 149.8 1.2e-35
XP_006714200 (OMIM: 264900,612416) PREDICTED: coag ( 610) 636 149.9 1.3e-35
NP_000119 (OMIM: 264900,612416) coagulation factor ( 625) 636 149.9 1.3e-35
XP_005262878 (OMIM: 264900,612416) PREDICTED: coag ( 626) 636 149.9 1.3e-35
NP_002764 (OMIM: 600823) prostasin preproprotein [ ( 343) 633 149.0 1.4e-35
XP_016863673 (OMIM: 229000,612423) PREDICTED: plas ( 436) 633 149.1 1.6e-35
NP_001305325 (OMIM: 229000,612423) plasma kallikre ( 436) 633 149.1 1.6e-35
NP_000883 (OMIM: 229000,612423) plasma kallikrein ( 638) 633 149.2 2.1e-35
XP_011530232 (OMIM: 229000,612423) PREDICTED: plas ( 649) 633 149.2 2.2e-35
XP_016863670 (OMIM: 229000,612423) PREDICTED: plas ( 649) 633 149.2 2.2e-35
NP_001243246 (OMIM: 605511) transmembrane protease ( 453) 625 147.3 5.7e-35
NP_001275930 (OMIM: 206200,609862) transmembrane p ( 802) 626 147.8 7.4e-35
NP_705837 (OMIM: 206200,609862) transmembrane prot ( 811) 626 147.8 7.5e-35
NP_115780 (OMIM: 605511) transmembrane protease se ( 327) 614 144.7 2.4e-34
NP_076927 (OMIM: 605511) transmembrane protease se ( 454) 614 144.9 3.1e-34
XP_011528035 (OMIM: 602060) PREDICTED: transmembra ( 384) 613 144.6 3.2e-34
XP_005261100 (OMIM: 602060) PREDICTED: transmembra ( 452) 613 144.7 3.6e-34
NP_005647 (OMIM: 602060) transmembrane protease se ( 492) 613 144.7 3.8e-34
XP_011528033 (OMIM: 602060) PREDICTED: transmembra ( 492) 613 144.7 3.8e-34
NP_001128571 (OMIM: 602060) transmembrane protease ( 529) 613 144.7 4e-34
NP_001277025 (OMIM: 606565) transmembrane protease ( 290) 590 139.4 8.9e-33
NP_001167023 (OMIM: 606565) transmembrane protease ( 397) 590 139.5 1.1e-32
NP_001277023 (OMIM: 606565) transmembrane protease ( 412) 590 139.5 1.2e-32
NP_003285 (OMIM: 191080) tryptase alpha/beta-1 pre ( 275) 588 138.9 1.2e-32
NP_001077416 (OMIM: 606565) transmembrane protease ( 432) 590 139.5 1.2e-32
NP_001167022 (OMIM: 606565) transmembrane protease ( 435) 590 139.5 1.2e-32
NP_063947 (OMIM: 606565) transmembrane protease se ( 437) 590 139.5 1.2e-32
NP_000292 (OMIM: 173350,217090) plasminogen isofor ( 810) 586 138.9 3.5e-32
NP_077078 (OMIM: 191081) tryptase beta-2 prepropro ( 275) 579 136.9 4.7e-32
XP_005271672 (OMIM: 606565) PREDICTED: transmembra ( 454) 578 136.9 7.8e-32
XP_011541204 (OMIM: 606565) PREDICTED: transmembra ( 456) 578 136.9 7.9e-32
XP_011541203 (OMIM: 606565) PREDICTED: transmembra ( 489) 578 136.9 8.3e-32
XP_005271671 (OMIM: 606565) PREDICTED: transmembra ( 492) 578 136.9 8.3e-32
XP_005271670 (OMIM: 606565) PREDICTED: transmembra ( 494) 578 136.9 8.3e-32
NP_892018 (OMIM: 610477) transmembrane protease se (1059) 560 133.2 2.3e-30
XP_011526280 (OMIM: 610477) PREDICTED: transmembra (1093) 560 133.2 2.4e-30
NP_001898 (OMIM: 118888) chymotrypsin-like proteas ( 264) 552 130.9 2.9e-30
NP_002763 (OMIM: 226200,606635) enteropeptidase pr (1019) 552 131.4 7.7e-30
XP_011527961 (OMIM: 226200,606635) PREDICTED: ente (1034) 552 131.4 7.8e-30
>>NP_071402 (OMIM: 609343) brain-specific serine proteas (317 aa)
initn: 631 init1: 252 opt: 652 Z-score: 783.2 bits: 153.2 E(85289): 6.9e-37
Smith-Waterman score: 652; 36.1% identity (61.8% similar) in 288 aa overlap (11-288:10-285)
10 20 30 40 50
pF1KE6 MAAPASVMGPLGPSALGLLLLLLVVAPPRV--AALVHRQPENQGISLTGSVACGRPSMEG
:: . :: . ::..: . :: . : :::.:.. .
NP_071 MVVSGAPPALGGGCLGTFTSLLLLASTAILNAARIPVPP-----------ACGKPQQLN
10 20 30 40
60 70 80 90 100 110
pF1KE6 KILGGVPAPERKWPWQVSVHYAGLHVCGGSILNEYWVLSAAHCFHRDKNIK-IYDMYVGL
...:: . . .::: ::.. : : :.::.:. ::..:::::. . : .... .:
NP_071 RVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGA
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE6 VNLRVDGNHTQWYEVNRVILHPTYEMYHPIGGDVALVQLKTRIVFSESVLPVCLATPEVN
.: :...: : : ::.: . .:.:::.:. : ::: :::.:: ..
NP_071 WQLGNPGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIH
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE6 LT-SANCWATGWGLVSKQG---ETSDELQEVQLPLILEPWCHLLY---GHMSYIMPDMLC
: ...:: .::: . ..: . ::....:.: : :: . .. : ::::
NP_071 LPPNTHCWISGWGSI-QDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLC
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE6 AGDILNAKTVCEGDSGGPLVCEFNRSWLQIGIVSWGRGCSNPLYPGVYASVSYFSKWICD
:: . . . .: :::::::.:. . .:: ::.:::.::.. :::: :.: .:.
NP_071 AGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEK
230 240 250 260 270 280
300 310 320
pF1KE6 NIEITPTPAQPAPALSPALGPTLSVLMAMLAGWSVL
NP_071 IVQGVQLRGRAQGGGALRAPSQGSGAAARS
290 300 310
>>XP_005255530 (OMIM: 609343) PREDICTED: brain-specific (317 aa)
initn: 631 init1: 252 opt: 652 Z-score: 783.2 bits: 153.2 E(85289): 6.9e-37
Smith-Waterman score: 652; 36.1% identity (61.8% similar) in 288 aa overlap (11-288:10-285)
10 20 30 40 50
pF1KE6 MAAPASVMGPLGPSALGLLLLLLVVAPPRV--AALVHRQPENQGISLTGSVACGRPSMEG
:: . :: . ::..: . :: . : :::.:.. .
XP_005 MVVSGAPPALGGGCLGTFTSLLLLASTAILNAARIPVPP-----------ACGKPQQLN
10 20 30 40
60 70 80 90 100 110
pF1KE6 KILGGVPAPERKWPWQVSVHYAGLHVCGGSILNEYWVLSAAHCFHRDKNIK-IYDMYVGL
...:: . . .::: ::.. : : :.::.:. ::..:::::. . : .... .:
XP_005 RVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPYLFSVLLGA
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE6 VNLRVDGNHTQWYEVNRVILHPTYEMYHPIGGDVALVQLKTRIVFSESVLPVCLATPEVN
.: :...: : : ::.: . .:.:::.:. : ::: :::.:: ..
XP_005 WQLGNPGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLPICLPDASIH
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE6 LT-SANCWATGWGLVSKQG---ETSDELQEVQLPLILEPWCHLLY---GHMSYIMPDMLC
: ...:: .::: . ..: . ::....:.: : :: . .. : ::::
XP_005 LPPNTHCWISGWGSI-QDGVPLPHPQTLQKLKVPIIDSEVCSHLYWRGAGQGPITEDMLC
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE6 AGDILNAKTVCEGDSGGPLVCEFNRSWLQIGIVSWGRGCSNPLYPGVYASVSYFSKWICD
:: . . . .: :::::::.:. . .:: ::.:::.::.. :::: :.: .:.
XP_005 AGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYISLSAHRSWVEK
230 240 250 260 270 280
300 310 320
pF1KE6 NIEITPTPAQPAPALSPALGPTLSVLMAMLAGWSVL
XP_005 IVQGVQLRGRAQGGGALRAPSQGSGAAARS
290 300 310
>>NP_036599 (OMIM: 609341) tryptase gamma preproprotein (321 aa)
initn: 603 init1: 229 opt: 651 Z-score: 782.0 bits: 152.9 E(85289): 8.1e-37
Smith-Waterman score: 655; 37.9% identity (59.9% similar) in 317 aa overlap (15-320:2-297)
10 20 30 40 50
pF1KE6 MAAPASVMGPLGPSALGLLLLLLVVAPPRVAALVHRQPENQGISLTGSVACGRPSME---
::: :::..: : :. : :: .::::..
NP_036 MALGACGLLLLLAVPGVS-LRTLQP-----------GCGRPQVSDAG
10 20 30
60 70 80 90 100 110
pF1KE6 GKILGGVPAPERKWPWQVSVHYAGLHVCGGSILNEYWVLSAAHCFHRDKNIKIYDMYVGL
:.:.:: :: ::::.:.. .::::::.:. :::.::::: . : . :....:
NP_036 GRIVGGHAAPAGAWPWQASLRLRRVHVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGE
40 50 60 70 80 90
120 130 140 150 160 170
pF1KE6 VNLRVDGNHTQWYEVNRVILHPTYEMYHPIGGDVALVQLKTRIVFSESVLPVCLATPEVN
... .. . . : ..::: . .::.:::.:.. ...: .::::: ::..
NP_036 LEITLSPHFST---VRQIILHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCL--PEAS
100 110 120 130 140 150
180 190 200 210 220
pF1KE6 ---LTSANCWATGWGLVSKQGETSDE---LQEVQLPLILEPWCHLLY-GHMSYIM-PDML
. ::.:::: ...:: :.::.. .. :. : : . :. ::::
NP_036 DDFCPGIRCWVTGWGY-TREGEPLPPPYSLREVKVSVVDTETCRRDYPGPGGSILQPDML
160 170 180 190 200
230 240 250 260 270 280
pF1KE6 CAGDILNAKTVCEGDSGGPLVCEFNRSWLQIGIVSWGRGCSNPLYPGVYASVSYFSKWIC
:: .: :. ::::::::. : .:.: ::::::.::. : ::::. : . .::
NP_036 CARGPGDA---CQDDSGGPLVCQVNGAWVQAGIVSWGEGCGRPNRPGVYTRVPAYVNWIR
210 220 230 240 250 260
290 300 310 320
pF1KE6 DNIEITPTPAQPAPALSPALGPTLSVLMAMLAGWSVL
.: . . : : : : :. .:
NP_036 RHITASGGSESGYPRLPLLAGFFLPGLFLLLVSCVLLAKCLLHPSADGTPFPAPD
270 280 290 300 310 320
>>NP_001275679 (OMIM: 606751) transmembrane protease ser (413 aa)
initn: 578 init1: 313 opt: 652 Z-score: 781.7 bits: 153.3 E(85289): 8.4e-37
Smith-Waterman score: 652; 38.3% identity (65.0% similar) in 277 aa overlap (28-293:136-409)
10 20 30 40 50
pF1KE6 MAAPASVMGPLGPSALGLLLLLLVVAPPRVAALVHR--QPEN-----QGISLTGSVA
::....... ::.: : .:: :
NP_001 SLGHLRLTHHKGVNLTDIKLNSSQEFAQLSPRLGGFLEEAWQPRNNCTSGQVVSLRCS-E
110 120 130 140 150 160
60 70 80 90 100
pF1KE6 CGRPSMEGKILGGVPAPERKWPWQVSVHYAGLHVCGGSILNEYWVLSAAHCFH--RDKNI
:: . ..:.:: . .::::.:: . :.::::.: ::..::::.: : .
NP_001 CGARPLASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARL
170 180 190 200 210 220
110 120 130 140 150 160
pF1KE6 KIYDMYVGLVNLRVDGNHTQWYEVNRVILHPTYEMYHPIGGDVALVQLKTRIVFSESVLP
. . ...:::. . : : :.:.: :: : . ::::..:.: . ::..:
NP_001 SSWRVHAGLVSHSAVRPH-QGALVERIIPHPLYSAQNH-DYDVALLRLQTALNFSDTVGA
230 240 250 260 270 280
170 180 190 200 210 220
pF1KE6 VCLATPEVNLTSAN-CWATGWGLVS-KQGETSDELQEVQLPLILEPWCHLLYGHMSYIMP
::: . : .. ... ::..::: . .. .:: ::.. .::. :. . . . :
NP_001 VCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTP
290 300 310 320 330 340
230 240 250 260 270 280
pF1KE6 DMLCAGDILNAKTVCEGDSGGPLVCEFNRSWLQIGIVSWGRGCSNPLYPGVYASVSYFSK
::::: . . .:.::::::::: . .: .:.:::::::..: .:::::.:. :
NP_001 RMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLD
350 360 370 380 390 400
290 300 310 320
pF1KE6 WICDNIEITPTPAQPAPALSPALGPTLSVLMAMLAGWSVL
:: :. .
NP_001 WIHDTAQDSLL
410
>>NP_001275680 (OMIM: 606751) transmembrane protease ser (448 aa)
initn: 578 init1: 313 opt: 652 Z-score: 781.3 bits: 153.3 E(85289): 8.9e-37
Smith-Waterman score: 652; 38.3% identity (65.0% similar) in 277 aa overlap (28-293:171-444)
10 20 30 40 50
pF1KE6 MAAPASVMGPLGPSALGLLLLLLVVAPPRVAALVHR--QPEN-----QGISLTGSVA
::....... ::.: : .:: :
NP_001 SLGHLRLTHHKGVNLTDIKLNSSQEFAQLSPRLGGFLEEAWQPRNNCTSGQVVSLRCS-E
150 160 170 180 190
60 70 80 90 100
pF1KE6 CGRPSMEGKILGGVPAPERKWPWQVSVHYAGLHVCGGSILNEYWVLSAAHCFH--RDKNI
:: . ..:.:: . .::::.:: . :.::::.: ::..::::.: : .
NP_001 CGARPLASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARL
200 210 220 230 240 250
110 120 130 140 150 160
pF1KE6 KIYDMYVGLVNLRVDGNHTQWYEVNRVILHPTYEMYHPIGGDVALVQLKTRIVFSESVLP
. . ...:::. . : : :.:.: :: : . ::::..:.: . ::..:
NP_001 SSWRVHAGLVSHSAVRPH-QGALVERIIPHPLYSAQNH-DYDVALLRLQTALNFSDTVGA
260 270 280 290 300 310
170 180 190 200 210 220
pF1KE6 VCLATPEVNLTSAN-CWATGWGLVS-KQGETSDELQEVQLPLILEPWCHLLYGHMSYIMP
::: . : .. ... ::..::: . .. .:: ::.. .::. :. . . . :
NP_001 VCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTP
320 330 340 350 360 370
230 240 250 260 270 280
pF1KE6 DMLCAGDILNAKTVCEGDSGGPLVCEFNRSWLQIGIVSWGRGCSNPLYPGVYASVSYFSK
::::: . . .:.::::::::: . .: .:.:::::::..: .:::::.:. :
NP_001 RMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLD
380 390 400 410 420 430
290 300 310 320
pF1KE6 WICDNIEITPTPAQPAPALSPALGPTLSVLMAMLAGWSVL
:: :. .
NP_001 WIHDTAQDSLL
440
>>NP_110397 (OMIM: 606751) transmembrane protease serine (457 aa)
initn: 578 init1: 313 opt: 652 Z-score: 781.2 bits: 153.3 E(85289): 9e-37
Smith-Waterman score: 652; 38.3% identity (65.0% similar) in 277 aa overlap (28-293:180-453)
10 20 30 40 50
pF1KE6 MAAPASVMGPLGPSALGLLLLLLVVAPPRVAALVHR--QPEN-----QGISLTGSVA
::....... ::.: : .:: :
NP_110 SLGHLRLTHHKGVNLTDIKLNSSQEFAQLSPRLGGFLEEAWQPRNNCTSGQVVSLRCS-E
150 160 170 180 190 200
60 70 80 90 100
pF1KE6 CGRPSMEGKILGGVPAPERKWPWQVSVHYAGLHVCGGSILNEYWVLSAAHCFH--RDKNI
:: . ..:.:: . .::::.:: . :.::::.: ::..::::.: : .
NP_110 CGARPLASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARL
210 220 230 240 250 260
110 120 130 140 150 160
pF1KE6 KIYDMYVGLVNLRVDGNHTQWYEVNRVILHPTYEMYHPIGGDVALVQLKTRIVFSESVLP
. . ...:::. . : : :.:.: :: : . ::::..:.: . ::..:
NP_110 SSWRVHAGLVSHSAVRPH-QGALVERIIPHPLYSAQNH-DYDVALLRLQTALNFSDTVGA
270 280 290 300 310 320
170 180 190 200 210 220
pF1KE6 VCLATPEVNLTSAN-CWATGWGLVS-KQGETSDELQEVQLPLILEPWCHLLYGHMSYIMP
::: . : .. ... ::..::: . .. .:: ::.. .::. :. . . . :
NP_110 VCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTP
330 340 350 360 370 380
230 240 250 260 270 280
pF1KE6 DMLCAGDILNAKTVCEGDSGGPLVCEFNRSWLQIGIVSWGRGCSNPLYPGVYASVSYFSK
::::: . . .:.::::::::: . .: .:.:::::::..: .:::::.:. :
NP_110 RMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLD
390 400 410 420 430 440
290 300 310 320
pF1KE6 WICDNIEITPTPAQPAPALSPALGPTLSVLMAMLAGWSVL
:: :. .
NP_110 WIHDTAQDSLL
450
>>XP_011520749 (OMIM: 609341) PREDICTED: tryptase gamma (346 aa)
initn: 547 init1: 223 opt: 639 Z-score: 767.2 bits: 150.3 E(85289): 5.4e-36
Smith-Waterman score: 639; 37.2% identity (61.4% similar) in 290 aa overlap (42-320:42-322)
20 30 40 50 60
pF1KE6 GPSALGLLLLLLVVAPPRVAALVHRQPENQGISLTGSVACGRPSME---GKILGGVPAPE
: . ...::::.. :.:.:: ::
XP_011 LKSKVPKKAGRCGQGRLHGGSAVGFLGSPPGTPSSFDLGCGRPQVSDAGGRIVGGHAAPA
20 30 40 50 60 70
70 80 90 100 110 120
pF1KE6 RKWPWQVSVHYAGLHVCGGSILNEYWVLSAAHCFHRDKNIKIYDMYVGLVNLRVDGNHTQ
::::.:.. .::::::.:. :::.::::: . : . :....: ... .. . .
XP_011 GAWPWQASLRLRRVHVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGELEITLSPHFST
80 90 100 110 120 130
130 140 150 160 170 180
pF1KE6 WYEVNRVILHPTYEMYHPIGGDVALVQLKTRIVFSESVLPVCLATPEVN---LTSANCWA
: ..::: . .::.:::.:.. ...: .::::: ::.. . ::.
XP_011 ---VRQIILHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCL--PEASDDFCPGIRCWV
140 150 160 170 180
190 200 210 220 230 240
pF1KE6 TGWGLVSKQGETSDE---LQEVQLPLILEPWCHLLY-GHMSYIM-PDMLCAGDILNAKTV
:::: ...:: :.::.. .. :. : : . :. :::::: .:
XP_011 TGWGY-TREGEPLPPPYSLREVKVSVVDTETCRRDYPGPGGSILQPDMLCARGPGDA---
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 CEGDSGGPLVCEFNRSWLQIGIVSWGRGCSNPLYPGVYASVSYFSKWICDNIEITPTPAQ
:. ::::::::. : .:.: : ::::.::. : ::::. : . .:: .: . .
XP_011 CQDDSGGPLVCQVNGAWVQAGTVSWGEGCGRPNRPGVYTRVPAYVNWIRRHITASGGSES
250 260 270 280 290 300
310 320
pF1KE6 PAPALSPALGPTLSVLMAMLAGWSVL
: : : : :. .:
XP_011 GYPRLPLLAGFFLPGLFLLLVSCVLLAKCLLHPSADGTPFPAPD
310 320 330 340
>>XP_011520748 (OMIM: 609341) PREDICTED: tryptase gamma (346 aa)
initn: 547 init1: 223 opt: 639 Z-score: 767.2 bits: 150.3 E(85289): 5.4e-36
Smith-Waterman score: 639; 37.2% identity (61.4% similar) in 290 aa overlap (42-320:42-322)
20 30 40 50 60
pF1KE6 GPSALGLLLLLLVVAPPRVAALVHRQPENQGISLTGSVACGRPSME---GKILGGVPAPE
: . ...::::.. :.:.:: ::
XP_011 LKSKVPKKAGRCGQGRLHGGSAVGFLGSPPGTPSSFDLGCGRPQVSDAGGRIVGGHAAPA
20 30 40 50 60 70
70 80 90 100 110 120
pF1KE6 RKWPWQVSVHYAGLHVCGGSILNEYWVLSAAHCFHRDKNIKIYDMYVGLVNLRVDGNHTQ
::::.:.. .::::::.:. :::.::::: . : . :....: ... .. . .
XP_011 GAWPWQASLRLRRVHVCGGSLLSPQWVLTAAHCFSGSLNSSDYQVHLGELEITLSPHFST
80 90 100 110 120 130
130 140 150 160 170 180
pF1KE6 WYEVNRVILHPTYEMYHPIGGDVALVQLKTRIVFSESVLPVCLATPEVN---LTSANCWA
: ..::: . .::.:::.:.. ...: .::::: ::.. . ::.
XP_011 ---VRQIILHSSPSGQPGTSGDIALVELSVPVTLSSRILPVCL--PEASDDFCPGIRCWV
140 150 160 170 180
190 200 210 220 230 240
pF1KE6 TGWGLVSKQGETSDE---LQEVQLPLILEPWCHLLY-GHMSYIM-PDMLCAGDILNAKTV
:::: ...:: :.::.. .. :. : : . :. :::::: .:
XP_011 TGWGY-TREGEPLPPPYSLREVKVSVVDTETCRRDYPGPGGSILQPDMLCARGPGDA---
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 CEGDSGGPLVCEFNRSWLQIGIVSWGRGCSNPLYPGVYASVSYFSKWICDNIEITPTPAQ
:. ::::::::. : .:.: : ::::.::. : ::::. : . .:: .: . .
XP_011 CQDDSGGPLVCQVNGAWVQAGTVSWGEGCGRPNRPGVYTRVPAYVNWIRRHITASGGSES
250 260 270 280 290 300
310 320
pF1KE6 PAPALSPALGPTLSVLMAMLAGWSVL
: : : : :. .:
XP_011 GYPRLPLLAGFFLPGLFLLLVSCVLLAKCLLHPSADGTPFPAPD
310 320 330 340
>>NP_001193718 (OMIM: 610050) transmembrane protease ser (532 aa)
initn: 476 init1: 441 opt: 638 Z-score: 763.5 bits: 150.3 E(85289): 8.7e-36
Smith-Waterman score: 638; 37.6% identity (65.0% similar) in 266 aa overlap (34-293:264-524)
10 20 30 40 50 60
pF1KE6 PASVMGPLGPSALGLLLLLLVVAPPRVAALVHRQ--PENQGISLTGSVACGRPSMEGKIL
.::. : .. ::: : :: .: :.:.
NP_001 ESAHRTTEVAHRDFANSFSILRYNSTIQESLHRSECPSQRYISLQCS-HCGLRAMTGRIV
240 250 260 270 280 290
70 80 90 100 110
pF1KE6 GGVPAPERKWPWQVSVHYAGLHVCGGSILNEYWVLSAAHCFH--RDKNIKIYDMYVGLVN
::. : . :::::::.:.. :.:::.... :::.::::: :.: .. . .:.: :
NP_001 GGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVYAGTSN
300 310 320 330 340 350
120 130 140 150 160 170
pF1KE6 LRVDGNHTQWYEVNRVILHPTYEMYHPIGGDVALVQLKTRIVFSESVLPVCLATPEVNLT
:. . . . ..:.. .: . :.::..:. ...: . :.:: ...
NP_001 LH---QLPEAASIAEIIINSNYTDEED-DYDIALMRLSKPLTLSAHIHPACLPMHGQTFS
360 370 380 390 400
180 190 200 210 220 230
pF1KE6 -SANCWATGWGLVSKQGE-TSDELQEVQLPLILEPWCHLLYGHMSYIMPDMLCAGDILNA
. .:: ::.: . . . :: :.:::. :: :. . ::. : :.::::. ..
NP_001 LNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGG
410 420 430 440 450 460
240 250 260 270 280 290
pF1KE6 KTVCEGDSGGPLVCEFNRSWLQIGIVSWGRGCSNPLYPGVYASVSYFSKWICDNIEITPT
. :.:::::::::: : : :..::: ::.. ::::..:. :: ...:
NP_001 RDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMESEVR
470 480 490 500 510 520
300 310 320
pF1KE6 PAQPAPALSPALGPTLSVLMAMLAGWSVL
NP_001 FRKS
530
>>NP_001231924 (OMIM: 610050) transmembrane protease ser (563 aa)
initn: 476 init1: 441 opt: 638 Z-score: 763.2 bits: 150.3 E(85289): 9e-36
Smith-Waterman score: 638; 37.6% identity (65.0% similar) in 266 aa overlap (34-293:299-559)
10 20 30 40 50 60
pF1KE6 PASVMGPLGPSALGLLLLLLVVAPPRVAALVHRQ--PENQGISLTGSVACGRPSMEGKIL
.::. : .. ::: : :: .: :.:.
NP_001 ESAHRTTEVAHRDFANSFSILRYNSTIQESLHRSECPSQRYISLQCS-HCGLRAMTGRIV
270 280 290 300 310 320
70 80 90 100 110
pF1KE6 GGVPAPERKWPWQVSVHYAGLHVCGGSILNEYWVLSAAHCFH--RDKNIKIYDMYVGLVN
::. : . :::::::.:.. :.:::.... :::.::::: :.: .. . .:.: :
NP_001 GGALASDSKWPWQVSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVYAGTSN
330 340 350 360 370 380
120 130 140 150 160 170
pF1KE6 LRVDGNHTQWYEVNRVILHPTYEMYHPIGGDVALVQLKTRIVFSESVLPVCLATPEVNLT
:. . . . ..:.. .: . :.::..:. ...: . :.:: ...
NP_001 LH---QLPEAASIAEIIINSNYTDEED-DYDIALMRLSKPLTLSAHIHPACLPMHGQTFS
390 400 410 420 430 440
180 190 200 210 220 230
pF1KE6 -SANCWATGWGLVSKQGE-TSDELQEVQLPLILEPWCHLLYGHMSYIMPDMLCAGDILNA
. .:: ::.: . . . :: :.:::. :: :. . ::. : :.::::. ..
NP_001 LNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGG
450 460 470 480 490 500
240 250 260 270 280 290
pF1KE6 KTVCEGDSGGPLVCEFNRSWLQIGIVSWGRGCSNPLYPGVYASVSYFSKWICDNIEITPT
. :.:::::::::: : : :..::: ::.. ::::..:. :: ...:
NP_001 RDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMESSAG
510 520 530 540 550 560
300 310 320
pF1KE6 PAQPAPALSPALGPTLSVLMAMLAGWSVL
326 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 12:33:08 2016 done: Tue Nov 8 12:33:09 2016
Total Scan time: 6.220 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]