Result of FASTA (omim) for
pFN21AE6338
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6338, 313 aa
1>>>pF1KE6338 313 - 313 aa - 313 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3640+/-0.000399; mu= 15.1987+/- 0.025
mean_var=68.7673+/-14.250, 0's: 0 Z-trim(113.0): 16 B-trim: 1200 in 2/48
Lambda= 0.154662
statistics sampled from 22089 (22098) to 22089 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.643), E-opt: 0.2 (0.259), width: 16
Scan time: 4.680
The best scores are: opt bits E(85289)
NP_001121557 (OMIM: 271900,608034) aspartoacylase ( 313) 2146 487.9 1.1e-137
XP_016880150 (OMIM: 271900,608034) PREDICTED: aspa ( 313) 2146 487.9 1.1e-137
NP_000040 (OMIM: 271900,608034) aspartoacylase [Ho ( 313) 2146 487.9 1.1e-137
NP_542389 (OMIM: 614413) N-acyl-aromatic-L-amino a ( 319) 981 228.0 2e-59
XP_016874039 (OMIM: 614413) PREDICTED: N-acyl-arom ( 326) 961 223.5 4.5e-58
XP_016874038 (OMIM: 614413) PREDICTED: N-acyl-arom ( 326) 961 223.5 4.5e-58
XP_016874040 (OMIM: 614413) PREDICTED: N-acyl-arom ( 302) 877 204.8 1.8e-52
>>NP_001121557 (OMIM: 271900,608034) aspartoacylase [Hom (313 aa)
initn: 2146 init1: 2146 opt: 2146 Z-score: 2592.9 bits: 487.9 E(85289): 1.1e-137
Smith-Waterman score: 2146; 100.0% identity (100.0% similar) in 313 aa overlap (1-313:1-313)
10 20 30 40 50 60
pF1KE6 MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKPFITNPRAVKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKPFITNPRAVKK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 CTRYIDCDLNRIFDLENLGKKMSEDLPYEVRRAQEINHLFGPKDSEDSYDIIFDLHNTTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CTRYIDCDLNRIFDLENLGKKMSEDLPYEVRRAQEINHLFGPKDSEDSYDIIFDLHNTTS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 NMGCTLILEDSRNNFLIQMFHYIKTSLAPLPCYVYLIEHPSLKYATTRSIAKYPVGIEVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NMGCTLILEDSRNNFLIQMFHYIKTSLAPLPCYVYLIEHPSLKYATTRSIAKYPVGIEVG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 PQPQGVLRADILDQMRKMIKHALDFIHHFNEGKEFPPCAIEVYKIIEKVDYPRDENGEIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQPQGVLRADILDQMRKMIKHALDFIHHFNEGKEFPPCAIEVYKIIEKVDYPRDENGEIA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 AIIHPNLQDQDWKPLHPGDPMFLTLDGKTIPLGGDCTVYPVFVNEAAYYEKKEAFAKTTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AIIHPNLQDQDWKPLHPGDPMFLTLDGKTIPLGGDCTVYPVFVNEAAYYEKKEAFAKTTK
250 260 270 280 290 300
310
pF1KE6 LTLNAKSIRCCLH
:::::::::::::
NP_001 LTLNAKSIRCCLH
310
>>XP_016880150 (OMIM: 271900,608034) PREDICTED: aspartoa (313 aa)
initn: 2146 init1: 2146 opt: 2146 Z-score: 2592.9 bits: 487.9 E(85289): 1.1e-137
Smith-Waterman score: 2146; 100.0% identity (100.0% similar) in 313 aa overlap (1-313:1-313)
10 20 30 40 50 60
pF1KE6 MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKPFITNPRAVKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKPFITNPRAVKK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 CTRYIDCDLNRIFDLENLGKKMSEDLPYEVRRAQEINHLFGPKDSEDSYDIIFDLHNTTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CTRYIDCDLNRIFDLENLGKKMSEDLPYEVRRAQEINHLFGPKDSEDSYDIIFDLHNTTS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 NMGCTLILEDSRNNFLIQMFHYIKTSLAPLPCYVYLIEHPSLKYATTRSIAKYPVGIEVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NMGCTLILEDSRNNFLIQMFHYIKTSLAPLPCYVYLIEHPSLKYATTRSIAKYPVGIEVG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 PQPQGVLRADILDQMRKMIKHALDFIHHFNEGKEFPPCAIEVYKIIEKVDYPRDENGEIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQPQGVLRADILDQMRKMIKHALDFIHHFNEGKEFPPCAIEVYKIIEKVDYPRDENGEIA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 AIIHPNLQDQDWKPLHPGDPMFLTLDGKTIPLGGDCTVYPVFVNEAAYYEKKEAFAKTTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AIIHPNLQDQDWKPLHPGDPMFLTLDGKTIPLGGDCTVYPVFVNEAAYYEKKEAFAKTTK
250 260 270 280 290 300
310
pF1KE6 LTLNAKSIRCCLH
:::::::::::::
XP_016 LTLNAKSIRCCLH
310
>>NP_000040 (OMIM: 271900,608034) aspartoacylase [Homo s (313 aa)
initn: 2146 init1: 2146 opt: 2146 Z-score: 2592.9 bits: 487.9 E(85289): 1.1e-137
Smith-Waterman score: 2146; 100.0% identity (100.0% similar) in 313 aa overlap (1-313:1-313)
10 20 30 40 50 60
pF1KE6 MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKPFITNPRAVKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKPFITNPRAVKK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 CTRYIDCDLNRIFDLENLGKKMSEDLPYEVRRAQEINHLFGPKDSEDSYDIIFDLHNTTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 CTRYIDCDLNRIFDLENLGKKMSEDLPYEVRRAQEINHLFGPKDSEDSYDIIFDLHNTTS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 NMGCTLILEDSRNNFLIQMFHYIKTSLAPLPCYVYLIEHPSLKYATTRSIAKYPVGIEVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 NMGCTLILEDSRNNFLIQMFHYIKTSLAPLPCYVYLIEHPSLKYATTRSIAKYPVGIEVG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 PQPQGVLRADILDQMRKMIKHALDFIHHFNEGKEFPPCAIEVYKIIEKVDYPRDENGEIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PQPQGVLRADILDQMRKMIKHALDFIHHFNEGKEFPPCAIEVYKIIEKVDYPRDENGEIA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 AIIHPNLQDQDWKPLHPGDPMFLTLDGKTIPLGGDCTVYPVFVNEAAYYEKKEAFAKTTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AIIHPNLQDQDWKPLHPGDPMFLTLDGKTIPLGGDCTVYPVFVNEAAYYEKKEAFAKTTK
250 260 270 280 290 300
310
pF1KE6 LTLNAKSIRCCLH
:::::::::::::
NP_000 LTLNAKSIRCCLH
310
>>NP_542389 (OMIM: 614413) N-acyl-aromatic-L-amino acid (319 aa)
initn: 980 init1: 961 opt: 981 Z-score: 1187.9 bits: 228.0 E(85289): 2e-59
Smith-Waterman score: 981; 44.8% identity (76.0% similar) in 308 aa overlap (1-308:1-308)
10 20 30 40 50 60
pF1KE6 MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKPFITNPRAVKK
: : . .: ...::. :::::::..::.:..:::. ::.::... . : ..:: :..
NP_542 MCSLPVPREPLRRVAVTGGTHGNEMSGVYLARHWLHAPAELQRASFSAVPVLANPAATSG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 CTRYIDCDLNRIFDLENLGKKMSEDLPYEVRRAQEINHLFGPKDSEDSYDIIFDLHNTTS
: ::.: :::: : :... . : :::: ::.:.:.:.::: : ...:...::::::.
NP_542 CRRYVDHDLNRTFTSSFLNSRPTPDDPYEVTRARELNQLLGPKASGQAFDFVLDLHNTTA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 NMGCTLILEDSRNNFLIQMFHYIKTSLAPLPCYVYLIEHPSLKYATTRSIAKYPVGIEVG
::: :: ..:.. : ... .... . : : :.: .. . . . :.:: .:.:.:
NP_542 NMGTCLIAKSSHEVFAMHLCRHLQLQYPELSCQVFLYQRSGEESYNLDSVAKNGLGLELG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 PQPQGVLRADILDQMRKMIKHALDFIHHFNEGKEFPPCAIEVYKIIEKVDYPRDENGEIA
:::::::::::...:: .. .::::. ::.: :: .:.:. . ::.:: : :..:
NP_542 PQPQGVLRADIFSRMRTLVATVLDFIELFNQGTAFPAFEMEAYRPVGVVDFPRTEAGHLA
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 AIIHPNLQDQDWKPLHPGDPMFLTLDGKTIPLGGDCTVYPVFVNEAAYYEKKEAFAKTTK
. .::.:::.:..::.:: :.: ..:. . :. ::::::.:::::::: ::..: :
NP_542 GTVHPQLQDRDFQPLQPGAPIFQMFSGEDLLYEGESTVYPVFINEAAYYEKGVAFVQTEK
250 260 270 280 290 300
310
pF1KE6 LTLNAKSIRCCLH
.:... ..
NP_542 FTFTVPAMPALTPAPSPAS
310
>>XP_016874039 (OMIM: 614413) PREDICTED: N-acyl-aromatic (326 aa)
initn: 946 init1: 716 opt: 961 Z-score: 1163.6 bits: 223.5 E(85289): 4.5e-58
Smith-Waterman score: 961; 43.8% identity (74.6% similar) in 315 aa overlap (1-308:1-315)
10 20 30 40 50 60
pF1KE6 MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKPFITNPRAVKK
: : . .: ...::. :::::::..::.:..:::. ::.::... . : ..:: :..
XP_016 MCSLPVPREPLRRVAVTGGTHGNEMSGVYLARHWLHAPAELQRASFSAVPVLANPAATSG
10 20 30 40 50 60
70 80 90 100 110
pF1KE6 CTRYIDCDLNRIFDLE-------NLGKKMSEDLPYEVRRAQEINHLFGPKDSEDSYDIIF
: ::.: :::: : .:... . : :::: ::.:.:.:.::: : ...:...
XP_016 CRRYVDHDLNRTFTSSFLKPGSGQLSSRPTPDDPYEVTRARELNQLLGPKASGQAFDFVL
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE6 DLHNTTSNMGCTLILEDSRNNFLIQMFHYIKTSLAPLPCYVYLIEHPSLKYATTRSIAKY
::::::.::: :: ..:.. : ... .... . : : :.: .. . . . :.::
XP_016 DLHNTTANMGTCLIAKSSHEVFAMHLCRHLQLQYPELSCQVFLYQRSGEESYNLDSVAKN
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE6 PVGIEVGPQPQGVLRADILDQMRKMIKHALDFIHHFNEGKEFPPCAIEVYKIIEKVDYPR
.:.:.::::::::::::...:: .. .::::. ::.: :: .:.:. . ::.::
XP_016 GLGLELGPQPQGVLRADIFSRMRTLVATVLDFIELFNQGTAFPAFEMEAYRPVGVVDFPR
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE6 DENGEIAAIIHPNLQDQDWKPLHPGDPMFLTLDGKTIPLGGDCTVYPVFVNEAAYYEKKE
: :..:. .::.:::.:..::.:: :.: ..:. . :. ::::::.::::::::
XP_016 TEAGHLAGTVHPQLQDRDFQPLQPGAPIFQMFSGEDLLYEGESTVYPVFINEAAYYEKGV
250 260 270 280 290 300
300 310
pF1KE6 AFAKTTKLTLNAKSIRCCLH
::..: :.:... ..
XP_016 AFVQTEKFTFTVPAMPALTPAPSPAS
310 320
>>XP_016874038 (OMIM: 614413) PREDICTED: N-acyl-aromatic (326 aa)
initn: 946 init1: 716 opt: 961 Z-score: 1163.6 bits: 223.5 E(85289): 4.5e-58
Smith-Waterman score: 961; 43.8% identity (74.6% similar) in 315 aa overlap (1-308:1-315)
10 20 30 40 50 60
pF1KE6 MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKPFITNPRAVKK
: : . .: ...::. :::::::..::.:..:::. ::.::... . : ..:: :..
XP_016 MCSLPVPREPLRRVAVTGGTHGNEMSGVYLARHWLHAPAELQRASFSAVPVLANPAATSG
10 20 30 40 50 60
70 80 90 100 110
pF1KE6 CTRYIDCDLNRIFDLE-------NLGKKMSEDLPYEVRRAQEINHLFGPKDSEDSYDIIF
: ::.: :::: : .:... . : :::: ::.:.:.:.::: : ...:...
XP_016 CRRYVDHDLNRTFTSSFLKPGSGQLSSRPTPDDPYEVTRARELNQLLGPKASGQAFDFVL
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE6 DLHNTTSNMGCTLILEDSRNNFLIQMFHYIKTSLAPLPCYVYLIEHPSLKYATTRSIAKY
::::::.::: :: ..:.. : ... .... . : : :.: .. . . . :.::
XP_016 DLHNTTANMGTCLIAKSSHEVFAMHLCRHLQLQYPELSCQVFLYQRSGEESYNLDSVAKN
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE6 PVGIEVGPQPQGVLRADILDQMRKMIKHALDFIHHFNEGKEFPPCAIEVYKIIEKVDYPR
.:.:.::::::::::::...:: .. .::::. ::.: :: .:.:. . ::.::
XP_016 GLGLELGPQPQGVLRADIFSRMRTLVATVLDFIELFNQGTAFPAFEMEAYRPVGVVDFPR
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE6 DENGEIAAIIHPNLQDQDWKPLHPGDPMFLTLDGKTIPLGGDCTVYPVFVNEAAYYEKKE
: :..:. .::.:::.:..::.:: :.: ..:. . :. ::::::.::::::::
XP_016 TEAGHLAGTVHPQLQDRDFQPLQPGAPIFQMFSGEDLLYEGESTVYPVFINEAAYYEKGV
250 260 270 280 290 300
300 310
pF1KE6 AFAKTTKLTLNAKSIRCCLH
::..: :.:... ..
XP_016 AFVQTEKFTFTVPAMPALTPAPSPAS
310 320
>>XP_016874040 (OMIM: 614413) PREDICTED: N-acyl-aromatic (302 aa)
initn: 877 init1: 716 opt: 877 Z-score: 1062.8 bits: 204.8 E(85289): 1.8e-52
Smith-Waterman score: 877; 43.3% identity (74.6% similar) in 291 aa overlap (25-308:1-291)
10 20 30 40 50 60
pF1KE6 MTSCHIAEEHIQKVAIFGGTHGNELTGVFLVKHWLENGAEIQRTGLEVKPFITNPRAVKK
..::.:..:::. ::.::... . : ..:: :..
XP_016 MSGVYLARHWLHAPAELQRASFSAVPVLANPAATSG
10 20 30
70 80 90 100 110
pF1KE6 CTRYIDCDLNRIFDLE-------NLGKKMSEDLPYEVRRAQEINHLFGPKDSEDSYDIIF
: ::.: :::: : .:... . : :::: ::.:.:.:.::: : ...:...
XP_016 CRRYVDHDLNRTFTSSFLKPGSGQLSSRPTPDDPYEVTRARELNQLLGPKASGQAFDFVL
40 50 60 70 80 90
120 130 140 150 160 170
pF1KE6 DLHNTTSNMGCTLILEDSRNNFLIQMFHYIKTSLAPLPCYVYLIEHPSLKYATTRSIAKY
::::::.::: :: ..:.. : ... .... . : : :.: .. . . . :.::
XP_016 DLHNTTANMGTCLIAKSSHEVFAMHLCRHLQLQYPELSCQVFLYQRSGEESYNLDSVAKN
100 110 120 130 140 150
180 190 200 210 220 230
pF1KE6 PVGIEVGPQPQGVLRADILDQMRKMIKHALDFIHHFNEGKEFPPCAIEVYKIIEKVDYPR
.:.:.::::::::::::...:: .. .::::. ::.: :: .:.:. . ::.::
XP_016 GLGLELGPQPQGVLRADIFSRMRTLVATVLDFIELFNQGTAFPAFEMEAYRPVGVVDFPR
160 170 180 190 200 210
240 250 260 270 280 290
pF1KE6 DENGEIAAIIHPNLQDQDWKPLHPGDPMFLTLDGKTIPLGGDCTVYPVFVNEAAYYEKKE
: :..:. .::.:::.:..::.:: :.: ..:. . :. ::::::.::::::::
XP_016 TEAGHLAGTVHPQLQDRDFQPLQPGAPIFQMFSGEDLLYEGESTVYPVFINEAAYYEKGV
220 230 240 250 260 270
300 310
pF1KE6 AFAKTTKLTLNAKSIRCCLH
::..: :.:... ..
XP_016 AFVQTEKFTFTVPAMPALTPAPSPAS
280 290 300
313 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 12:14:53 2016 done: Tue Nov 8 12:14:54 2016
Total Scan time: 4.680 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]