Result of FASTA (omim) for
pFN21AE6310
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6310, 417 aa
1>>>pF1KE6310 417 - 417 aa - 417 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.5948+/-0.00036; mu= 16.7395+/- 0.023
mean_var=76.1490+/-15.731, 0's: 0 Z-trim(114.2): 24 B-trim: 1210 in 2/52
Lambda= 0.146975
statistics sampled from 23875 (23896) to 23875 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.645), E-opt: 0.2 (0.28), width: 16
Scan time: 8.500
The best scores are: opt bits E(85289)
NP_005133 (OMIM: 261000,609342) gastric intrinsic ( 417) 2707 583.4 3.6e-166
XP_011543241 (OMIM: 261000,609342) PREDICTED: gast ( 403) 1780 386.8 5.3e-107
NP_001053 (OMIM: 189905) transcobalamin-1 precurso ( 433) 613 139.4 1.7e-32
NP_001171655 (OMIM: 275350,613441) transcobalamin- ( 400) 283 69.4 1.9e-11
NP_000346 (OMIM: 275350,613441) transcobalamin-2 i ( 427) 249 62.2 2.9e-09
>>NP_005133 (OMIM: 261000,609342) gastric intrinsic fact (417 aa)
initn: 2707 init1: 2707 opt: 2707 Z-score: 3104.2 bits: 583.4 E(85289): 3.6e-166
Smith-Waterman score: 2707; 100.0% identity (100.0% similar) in 417 aa overlap (1-417:1-417)
10 20 30 40 50 60
pF1KE6 MAWFALYLLSLLWATAGTSTQTQSSCSVPSAQEPLVNGIQVLMENSVTSSAYPNPSILIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MAWFALYLLSLLWATAGTSTQTQSSCSVPSAQEPLVNGIQVLMENSVTSSAYPNPSILIA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 MNLAGAYNLKAQKLLTYQLMSSDNNDLTIGQLGLTIMALTSSCRDPGDKVSILQRQMENW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MNLAGAYNLKAQKLLTYQLMSSDNNDLTIGQLGLTIMALTSSCRDPGDKVSILQRQMENW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 APSSPNAEASAFYGPSLAILALCQKNSEATLPIAVRFAKTLLANSSPFNVDTGAMATLAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 APSSPNAEASAFYGPSLAILALCQKNSEATLPIAVRFAKTLLANSSPFNVDTGAMATLAL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 TCMYNKIPVGSEEGYRSLFGQVLKDIVEKISMKIKDNGIIGDIYSTGLAMQALSVTPEPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TCMYNKIPVGSEEGYRSLFGQVLKDIVEKISMKIKDNGIIGDIYSTGLAMQALSVTPEPS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 KKEWNCKKTTDMILNEIKQGKFHNPMSIAQILPSLKGKTYLDVPQVTCSPDHEVQPTLPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KKEWNCKKTTDMILNEIKQGKFHNPMSIAQILPSLKGKTYLDVPQVTCSPDHEVQPTLPS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE6 NPGPGPTSASNITVIYTINNQLRGVELLFNETINVSVKSGSVLLVVLEEAQRKNPMFKFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 NPGPGPTSASNITVIYTINNQLRGVELLFNETINVSVKSGSVLLVVLEEAQRKNPMFKFE
310 320 330 340 350 360
370 380 390 400 410
pF1KE6 TTMTSWGLVVSSINNIAENVNHKTYWQFLSGVTPLNEGVADYIPFNHEHITANFTQY
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 TTMTSWGLVVSSINNIAENVNHKTYWQFLSGVTPLNEGVADYIPFNHEHITANFTQY
370 380 390 400 410
>>XP_011543241 (OMIM: 261000,609342) PREDICTED: gastric (403 aa)
initn: 2593 init1: 1776 opt: 1780 Z-score: 2042.1 bits: 386.8 E(85289): 5.3e-107
Smith-Waterman score: 2569; 96.6% identity (96.6% similar) in 417 aa overlap (1-417:1-403)
10 20 30 40 50 60
pF1KE6 MAWFALYLLSLLWATAGTSTQTQSSCSVPSAQEPLVNGIQVLMENSVTSSAYPNPSILIA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAWFALYLLSLLWATAGTSTQTQSSCSVPSAQEPLVNGIQVLMENSVTSSAYPNPSILIA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 MNLAGAYNLKAQKLLTYQLMSSDNNDLTIGQLGLTIMALTSSCRDPGDKVSILQRQMENW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MNLAGAYNLKAQKLLTYQLMSSDNNDLTIGQLGLTIMALTSSCRDPGDKVSILQRQMENW
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 APSSPNAEASAFYGPSLAILALCQKNSEATLPIAVRFAKTLLANSSPFNVDTGAMATLAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 APSSPNAEASAFYGPSLAILALCQKNSEATLPIAVRFAKTLLANSSPFNVDTGAMATLAL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 TCMYNKIPVGSEEGYRSLFGQVLKDIVEKISMKIKDNGIIGDIYSTGLAMQALSVTPEPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TCMYNKIPVGSEEGYRSLFGQVLKDIVEKISMKIKDNGIIGDIYSTGLAMQALSVTPEPS
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 KKEWNCKKTTDMILNEIKQGKFHNPMSIAQILPSLKGKTYLDVPQVTCSPDHEVQPTLPS
:::::::::::::::::::::::::::::::::::: ::::::::::
XP_011 KKEWNCKKTTDMILNEIKQGKFHNPMSIAQILPSLK--------------DHEVQPTLPS
250 260 270 280
310 320 330 340 350 360
pF1KE6 NPGPGPTSASNITVIYTINNQLRGVELLFNETINVSVKSGSVLLVVLEEAQRKNPMFKFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPGPGPTSASNITVIYTINNQLRGVELLFNETINVSVKSGSVLLVVLEEAQRKNPMFKFE
290 300 310 320 330 340
370 380 390 400 410
pF1KE6 TTMTSWGLVVSSINNIAENVNHKTYWQFLSGVTPLNEGVADYIPFNHEHITANFTQY
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TTMTSWGLVVSSINNIAENVNHKTYWQFLSGVTPLNEGVADYIPFNHEHITANFTQY
350 360 370 380 390 400
>>NP_001053 (OMIM: 189905) transcobalamin-1 precursor [H (433 aa)
initn: 505 init1: 179 opt: 613 Z-score: 704.3 bits: 139.4 E(85289): 1.7e-32
Smith-Waterman score: 649; 33.9% identity (61.7% similar) in 410 aa overlap (33-417:37-433)
10 20 30 40 50 60
pF1KE6 WFALYLLSLLWATAGTSTQTQSSCSVPSAQEPLVNGIQVLMENSVTSSAYPNPSILIAMN
.::.: . : ::.. .......
NP_001 LPLVGLLLFSFIPSQLCEICEVSEENYIRLKPLLNTMIQSNYNRGTSAV----NVVLSLK
10 20 30 40 50 60
70 80 90 100 110
pF1KE6 LAGAYNLKAQKLLTYQL---MSSDNNDLTIGQLGLTIMALTSSCRDPGDKVSI---LQRQ
:.: .. . :. ..: .:.. :.:.: :.:: . ::. ... : .
NP_001 LVGIQIQTLMQKMIQQIKYNVKSRLSDVSSGELALIILAL-GVCRNAEENLIYDYHLIDK
70 80 90 100 110 120
120 130 140 150 160
pF1KE6 MEN-WAPSSPNAEA------SAFYGPSLAILALCQKNSEATLPIAVRFAKTLLAN---SS
.:: . : :: . .: :: .:::: :.. . .: : .:
NP_001 LENKFQAEIENMEAHNGTPLTNYYQLSLDVLALCLFNGNYSTAEVVNHFTPENKNYYFGS
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE6 PFNVDTGAMATLALTCMYNKIPVG---SEEGYRSLFGQVLKDIVEKISMKIKDNGIIGDI
:.:::::::.:::::. ... : ..:: . .. :..:::: . :.::.::.
NP_001 QFSVDTGAMAVLALTCVKKSLINGQIKADEGSLKNISIYTKSLVEKILSEKKENGLIGNT
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE6 YSTGLAMQALSVTPEP-SKKEWNCKKTTDMILNEIKQGKFHNPMSIAQILPSLKGKTYLD
.::: ::::: :. . ....:::..: . .:.::.:: : :: . ::.::.: :::.::
NP_001 FSTGEAMQALFVSSDYYNENDWNCQQTLNTVLTEISQGAFSNPNAAAQVLPALMGKTFLD
250 260 270 280 290 300
290 300 310 320 330
pF1KE6 VPQ----VTCSPDHEVQPTLPSNPGPGPTSASNITVIYTINNQLRGVELLFNETINVSVK
. . :. : . ... : . : : : : :.: :.. : : :. ::.:
NP_001 INKDSSCVSASGNFNISADEPITVTP-PDSQSYISVNYSV----RINETYFT---NVTVL
310 320 330 340 350
340 350 360 370 380 390
pF1KE6 SGSVLLVVLEEAQRKNP-MFKFETTMTSWGLVVSSINNIAENVNHKTYWQFLSGVTPLNE
.:::.: :.:.::. : .: : ::: .. :... : : .:::..::: ::..
NP_001 NGSVFLSVMEKAQKMNDTIFGFTMEERSWGPYITCIQGLCANNNDRTYWELLSGGEPLSQ
360 370 380 390 400 410
400 410
pF1KE6 GVADYIPFNHEHITANFTQY
:...:. : :.. . ...:
NP_001 GAGSYVVRNGENLEVRWSKY
420 430
>>NP_001171655 (OMIM: 275350,613441) transcobalamin-2 is (400 aa)
initn: 193 init1: 65 opt: 283 Z-score: 326.6 bits: 69.4 E(85289): 1.9e-11
Smith-Waterman score: 366; 27.8% identity (55.7% similar) in 431 aa overlap (6-410:8-393)
10 20 30 40 50
pF1KE6 MAWFALYLLSLLWATAGTSTQTQSSCSVPSAQEPLVN--GIQVLMENSVTSSAYPNPS
:.::..: :. :. : .: . ::. : ..: . : . :::
NP_001 MRHLGAFLFLLGVL----GALTEM---CEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPS
10 20 30 40 50
60 70 80 90 100
pF1KE6 ILIAMNL----AGA------YNLKA--QKLLTYQLMSSDNNDL----TIGQLGLTIMALT
: ... : ::. ..:: :. : . .: :..: ..:::.: ..::
NP_001 IYVGLRLSSLQAGTKEDLYLHSLKLGYQQCLLGSAFSEDDGDCQGKPSMGQLALYLLALR
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE6 SSCRDPGDKVSILQRQMENWAPSSPNAEASAFYGPSLAILALCQKNSEATLPIAVRFAKT
. :: . . ..: .: .:.::::: ..... .. .
NP_001 A-----------------NWHDHKGHPHTS-YYQYGLGILALCLHQKRVHDSVVDK----
120 130 140 150
170 180 190 200 210
pF1KE6 LLANSSPFN-----VDTGAMATLALTCMYNKIPVGSEEGYRSLFGQVLKDIVEKISMKIK
:: ::. :::.::: ::.::. . . . : :. . .... . :.:
NP_001 LLYAVEPFHQGHHSVDTAAMAGLAFTCLKRS---NFNPGRRQRITMAIRTVREEILKAQT
160 170 180 190 200
220 230 240 250 260 270
pF1KE6 DNGIIGDIYSTGLAMQALSVTP-EPSKKEWNCKKTTDMILNEIKQGKFHNPMSIAQILPS
.: .:..::: ::.: : ..: . .. : :. .: ...: :.: . :.:.::
NP_001 PEGHFGNVYSTPLALQFLMTSPMRGAELGTACLKARVALLASLQDGAFQNALMISQLLPV
210 220 230 240 250 260
280 290 300 310 320 330
pF1KE6 LKGKTYLDVPQVTC-SPDHEVQPTLPSNPGPGPTSASNITVIYTINNQLRGVELLFNETI
:. :::.:. : .: ..:. . : ....: :. :. . ::
NP_001 LNHKTYIDLIFPDCLAPRVMLEPAAETIP-----QTQEI-----ISVTLQVLSLLPPYRQ
270 280 290 300 310
340 350 360 370 380 390
pF1KE6 NVSVKSGSVLLVVLEEAQRKNPMFKFETTMTSWGLVVSSINNIAENVNHKTYWQFLSGV-
..:: .::.. ::..:.. . : .:: . : ..:. ... .... .::.:
NP_001 SISVLAGSTVEDVLKKAHELGG-FTYETQASLSGPYLTSV--MGKAAGEREFWQLLRDPN
320 330 340 350 360 370
400 410
pF1KE6 TPLNEGVADYIPFNHEHITANFTQY
::: .:.::: : . : :
NP_001 TPLLQGIADYRPKDGETIELRLVSW
380 390 400
>>NP_000346 (OMIM: 275350,613441) transcobalamin-2 isofo (427 aa)
initn: 193 init1: 65 opt: 249 Z-score: 287.2 bits: 62.2 E(85289): 2.9e-09
Smith-Waterman score: 393; 28.2% identity (57.0% similar) in 440 aa overlap (6-410:8-420)
10 20 30 40 50
pF1KE6 MAWFALYLLSLLWATAGTSTQTQSSCSVPSAQEPLVN--GIQVLMENSVTSSAYPNPS
:.::..: :. :. : .: . ::. : ..: . : . :::
NP_000 MRHLGAFLFLLGVL----GALTEM---CEIPEMDSHLVEKLGQHLLPWMDRLSLEHLNPS
10 20 30 40 50
60 70 80 90 100
pF1KE6 ILIAMNL----AGA------YNLKA--QKLLTYQLMSSDNNDL----TIGQLGLTIMALT
: ... : ::. ..:: :. : . .: :..: ..:::.: ..::
NP_000 IYVGLRLSSLQAGTKEDLYLHSLKLGYQQCLLGSAFSEDDGDCQGKPSMGQLALYLLALR
60 70 80 90 100 110
110 120 130 140 150
pF1KE6 SSCR----DPGDK-VSILQRQMENW----APSSPNAEASAFYGPSLAILALCQKNSEATL
..:. ::. :: :. .:. . . . ...: .:.::::: .....
NP_000 ANCEFVRGHKGDRLVSQLKWFLEDEKRAIGHDHKGHPHTSYYQYGLGILALCLHQKRVHD
120 130 140 150 160 170
160 170 180 190 200
pF1KE6 PIAVRFAKTLLANSSPFN-----VDTGAMATLALTCMYNKIPVGSEEGYRSLFGQVLKDI
.. . :: ::. :::.::: ::.::. . . . : :. . .... .
NP_000 SVVDK----LLYAVEPFHQGHHSVDTAAMAGLAFTCLKRS---NFNPGRRQRITMAIRTV
180 190 200 210 220
210 220 230 240 250 260
pF1KE6 VEKISMKIKDNGIIGDIYSTGLAMQALSVTP-EPSKKEWNCKKTTDMILNEIKQGKFHNP
:.: .: .:..::: ::.: : ..: . .. : :. .: ...: :.:
NP_000 REEILKAQTPEGHFGNVYSTPLALQFLMTSPMRGAELGTACLKARVALLASLQDGAFQNA
230 240 250 260 270 280
270 280 290 300 310 320
pF1KE6 MSIAQILPSLKGKTYLDVPQVTC-SPDHEVQPTLPSNPGPGPTSASNITVIYTINNQLRG
. :.:.:: :. :::.:. : .: ..:. . : ....: :. :.
NP_000 LMISQLLPVLNHKTYIDLIFPDCLAPRVMLEPAAETIP-----QTQEI-----ISVTLQV
290 300 310 320 330
330 340 350 360 370 380
pF1KE6 VELLFNETINVSVKSGSVLLVVLEEAQRKNPMFKFETTMTSWGLVVSSINNIAENVNHKT
. :: ..:: .::.. ::..:.. . : .:: . : ..:. ... ....
NP_000 LSLLPPYRQSISVLAGSTVEDVLKKAHELGG-FTYETQASLSGPYLTSV--MGKAAGERE
340 350 360 370 380 390
390 400 410
pF1KE6 YWQFLSGV-TPLNEGVADYIPFNHEHITANFTQY
.::.: ::: .:.::: : . : :
NP_000 FWQLLRDPNTPLLQGIADYRPKDGETIELRLVSW
400 410 420
417 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 11:58:34 2016 done: Tue Nov 8 11:58:35 2016
Total Scan time: 8.500 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]