FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE6307, 314 aa
  1>>>pF1KE6307 314 - 314 aa - 314 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 5.2032+/-0.000443; mu= 16.5601+/- 0.027
 mean_var=72.5749+/-14.434, 0's: 0 Z-trim(110.7): 91  B-trim: 742 in 2/49
 Lambda= 0.150550
 statistics sampled from 19022 (19107) to 19022 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.589), E-opt: 0.2 (0.224), width:  16
 Scan time:  5.810

The best scores are:                                      opt bits E(85289)
NP_002345 (OMIM: 185535,613217,613244) epithelial  ( 314) 2046 453.9  2e-127
NP_002344 (OMIM: 137290,204870) tumor-associated c ( 323) 1012 229.3 8.1e-60
NP_004589 (OMIM: 602264) testican-1 precursor [Hom ( 439)  141 40.2  0.0092


>>NP_002345 (OMIM: 185535,613217,613244) epithelial cell  (314 aa)
 initn: 2046 init1: 2046 opt: 2046  Z-score: 2408.8  bits: 453.9 E(85289): 2e-127
Smith-Waterman score: 2046; 99.7% identity (99.7% similar) in 314 aa overlap (1-314:1-314)

               10        20        30        40        50        60
pF1KE6 MAPPQVLAFGLLLAAATATFAAAQEECVCENYKLAVNCFVNNNRQCQCTSVGAQNTVICS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MAPPQVLAFGLLLAAATATFAAAQEECVCENYKLAVNCFVNNNRQCQCTSVGAQNTVICS
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE6 KLAAKCLVMKAEMNGSKLGRRAKPEGALQNNDGLYDPDCDESGLFKAKQCNGTSTCWCVN
       :::::::::::::::::::::::::::::::::::::::::::::::::::::: :::::
NP_002 KLAAKCLVMKAEMNGSKLGRRAKPEGALQNNDGLYDPDCDESGLFKAKQCNGTSMCWCVN
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE6 TAGVRRTDKDTEITCSERVRTYWIIIELKHKAREKPYDSKSLRTALQKEITTRYQLDPKF
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 TAGVRRTDKDTEITCSERVRTYWIIIELKHKAREKPYDSKSLRTALQKEITTRYQLDPKF
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE6 ITSILYENNVITIDLVQNSSQKTQNDVDIADVAYYFEKDVKGESLFHSKKMDLTVNGEQL
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 ITSILYENNVITIDLVQNSSQKTQNDVDIADVAYYFEKDVKGESLFHSKKMDLTVNGEQL
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE6 DLDPGQTLIYYVDEKAPEFSMQGLKAGVIAVIVVVVIAVVAGIVVLVISRKKRMAKYEKA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 DLDPGQTLIYYVDEKAPEFSMQGLKAGVIAVIVVVVIAVVAGIVVLVISRKKRMAKYEKA
              250       260       270       280       290       300

              310    
pF1KE6 EIKEMGEMHRELNA
       ::::::::::::::
NP_002 EIKEMGEMHRELNA
              310    

>>NP_002344 (OMIM: 137290,204870) tumor-associated calci  (323 aa)
 initn: 922 init1: 415 opt: 1012  Z-score: 1194.9  bits: 229.3 E(85289): 8.1e-60
Smith-Waterman score: 1012; 49.7% identity (78.8% similar) in 316 aa overlap (1-311:7-320)

                      10        20        30        40        50   
pF1KE6       MAPPQV-LAFGLLLAAATATFAAAQEECVCENYKLAVNCFVNNNRQCQCTSVGA
             .::: . : . ::. ::..  .:::..:.: . :..:    . . .::: ..:.
NP_002 MARGPGLAPPPLRLPLLLLVLAAVTGHTAAQDNCTCPTNKMTVCSPDGPGGRCQCRALGS
               10        20        30        40        50        60

            60        70        80          90       100       110 
pF1KE6 QNTVICSKLAAKCLVMKAEMNGSKLGRR-AKP-EGALQNNDGLYDPDCDESGLFKAKQCN
         .: :: :..:::..::.:.. : .:  ..: : :: .::::::::::  : :::.:::
NP_002 GMAVDCSTLTSKCLLLKARMSAPKNARTLVRPSEHALVDNDGLYDPDCDPEGRFKARQCN
               70        80        90       100       110       120

             120        130       140       150       160       170
pF1KE6 GTSTCWCVNTAGVRRTDK-DTEITCSERVRTYWIIIELKHKAREKPYDSKSLRTALQKEI
        ::.:::::..::::::: :  . :.: :::. :.:.:.:.     .. ..: . :.. .
NP_002 QTSVCWCVNSVGVRRTDKGDLSLRCDELVRTHHILIDLRHRPTAGAFNHSDLDAELRRLF
              130       140       150       160       170       180

              180       190       200       210       220       230
pF1KE6 TTRYQLDPKFITSILYENNVITIDLVQNSSQKTQNDVDIADVAYYFEKDVKGESLFHSKK
         ::.: :::.... ::. .: :.: ::.:::. .::::.:.:::::.:.::::::... 
NP_002 RERYRLHPKFVAAVHYEQPTIQIELRQNTSQKAAGDVDIGDAAYYFERDIKGESLFQGRG
              190       200       210       220       230       240

               240       250       260       270       280         
pF1KE6 -MDLTVNGEQLDLDPGQTLIYYVDEKAPEFSMQGLKAGVIAVIVVVVIAVVAGIVVLVIS
        .:: : :: :...  .:::::.::  :.:::. : ::.::::::::.:.:::..::::.
NP_002 GLDLRVRGEPLQVE--RTLIYYLDEIPPKFSMKRLTAGLIAVIVVVVVALVAGMAVLVIT
              250         260       270       280       290        

     290       300       310    
pF1KE6 RKKRMAKYEKAEIKEMGEMHRELNA
        ... .::.:.::::.::...:   
NP_002 NRRKSGKYKKVEIKELGELRKEPSL
      300       310       320   

>>NP_004589 (OMIM: 602264) testican-1 precursor [Homo sa  (439 aa)
 initn: 104 init1:  53 opt: 141  Z-score: 170.6  bits: 40.2 E(85289): 0.0092
Smith-Waterman score: 154; 26.0% identity (50.7% similar) in 146 aa overlap (7-141:258-382)

                                       10          20              
pF1KE6                         MAPPQVLAFGLLL--AAATATFAAAQEECV------
                                     . . :::  .  .: .    : :.      
NP_004 TSSNTAQGRFDTSILPICKDSLGWMFNKLDMNYDLLLDPSEINAIYLDKYEPCIKPLFNS
       230       240       250       260       270       280       

       30        40        50        60        70        80        
pF1KE6 CENYKLAVNCFVNNNRQCQCTSVGAQNTVICSKLAAKCLVMKAEMNGSKLGRRAKPEGAL
       :...:   .  ..::. : : .    . . :          . :::  .. . .: .. :
NP_004 CDSFK---DGKLSNNEWCYCFQ--KPGGLPC----------QNEMN--RIQKLSKGKSLL
       290          300         310                   320       330

       90       100       110        120         130       140     
pF1KE6 QNNDGLYDPDCDESGLFKAKQCNG-TSTCWCVNTAG--VRRTDKDTEITCSERVRTYWII
           : . : :.: : .:: ::.: :. ::::.  :  .  . :.  ..: :. .:    
NP_004 ----GAFIPRCNEEGYYKATQCHGSTGQCWCVDKYGNELAGSRKQGAVSCEEEQETSGDF
                  340       350       360       370       380      

         150       160       170       180       190       200     
pF1KE6 IELKHKAREKPYDSKSLRTALQKEITTRYQLDPKFITSILYENNVITIDLVQNSSQKTQN
                                                                   
NP_004 GSGGSVVLLDDLEYERELGPKDKEGKLRVHTRAVTEDDEDEDDDKEDEVGYIW       
        390       400       410       420       430                




314 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Mon Nov  7 19:35:15 2016 done: Mon Nov  7 19:35:16 2016
 Total Scan time:  5.810 Total Display time:  0.000

Function used was FASTA [36.3.4 Apr, 2011]