Result of FASTA (omim) for
pFN21AE6303
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6303, 347 aa
1>>>pF1KE6303 347 - 347 aa - 347 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.7513+/-0.000353; mu= 19.1504+/- 0.022
mean_var=59.5744+/-11.943, 0's: 0 Z-trim(114.1): 17 B-trim: 284 in 2/48
Lambda= 0.166167
statistics sampled from 23800 (23808) to 23800 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.649), E-opt: 0.2 (0.279), width: 16
Scan time: 7.240
The best scores are: opt bits E(85289)
NP_839952 (OMIM: 601385,611093) tumor suppressor c ( 347) 2342 569.7 3.2e-162
NP_006756 (OMIM: 601385,611093) tumor suppressor c ( 348) 2318 564.0 1.7e-160
XP_011542954 (OMIM: 601385,611093) PREDICTED: tumo ( 292) 1952 476.2 3.9e-134
XP_016869350 (OMIM: 601385,611093) PREDICTED: tumo ( 292) 1952 476.2 3.9e-134
XP_011542953 (OMIM: 601385,611093) PREDICTED: tumo ( 303) 1947 475.0 9.1e-134
XP_016869349 (OMIM: 601385,611093) PREDICTED: tumo ( 305) 1947 475.0 9.2e-134
XP_011542956 (OMIM: 601385,611093) PREDICTED: tumo ( 258) 1743 426.1 4.2e-119
NP_115497 (OMIM: 300715,300853) magnesium transpor ( 367) 1643 402.2 9.2e-112
>>NP_839952 (OMIM: 601385,611093) tumor suppressor candi (347 aa)
initn: 2342 init1: 2342 opt: 2342 Z-score: 3033.4 bits: 569.7 E(85289): 3.2e-162
Smith-Waterman score: 2342; 100.0% identity (100.0% similar) in 347 aa overlap (1-347:1-347)
10 20 30 40 50 60
pF1KE6 MGARGAPSRRRQAGRRLRYLPTGSFPFLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_839 MGARGAPSRRRQAGRRLRYLPTGSFPFLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 SRRSIFRMNGDKFRKFIKAPPRNYSMIVMFTALQPQRQCSVCRQANEEYQILANSWRYSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_839 SRRSIFRMNGDKFRKFIKAPPRNYSMIVMFTALQPQRQCSVCRQANEEYQILANSWRYSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 AFCNKLFFSMVDYDEGTDVFQQLNMNSAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_839 AFCNKLFFSMVDYDEGTDVFQQLNMNSAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 WIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_839 WIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 AMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQAQFVAESHIILVLNAAITMGMVLLNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_839 AMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQAQFVAESHIILVLNAAITMGMVLLNE
250 260 270 280 290 300
310 320 330 340
pF1KE6 AATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPYSFLIK
:::::::::::::::::::::::::::::::::::::::::::::::
NP_839 AATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPYSFLIK
310 320 330 340
>>NP_006756 (OMIM: 601385,611093) tumor suppressor candi (348 aa)
initn: 2318 init1: 2318 opt: 2318 Z-score: 3002.3 bits: 564.0 E(85289): 1.7e-160
Smith-Waterman score: 2318; 100.0% identity (100.0% similar) in 343 aa overlap (1-343:1-343)
10 20 30 40 50 60
pF1KE6 MGARGAPSRRRQAGRRLRYLPTGSFPFLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MGARGAPSRRRQAGRRLRYLPTGSFPFLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE6 SRRSIFRMNGDKFRKFIKAPPRNYSMIVMFTALQPQRQCSVCRQANEEYQILANSWRYSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SRRSIFRMNGDKFRKFIKAPPRNYSMIVMFTALQPQRQCSVCRQANEEYQILANSWRYSS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE6 AFCNKLFFSMVDYDEGTDVFQQLNMNSAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 AFCNKLFFSMVDYDEGTDVFQQLNMNSAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE6 WIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 WIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVF
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE6 AMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQAQFVAESHIILVLNAAITMGMVLLNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 AMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQAQFVAESHIILVLNAAITMGMVLLNE
250 260 270 280 290 300
310 320 330 340
pF1KE6 AATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPYSFLIK
:::::::::::::::::::::::::::::::::::::::::::
NP_006 AATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPYSDLDFE
310 320 330 340
>>XP_011542954 (OMIM: 601385,611093) PREDICTED: tumor su (292 aa)
initn: 1952 init1: 1952 opt: 1952 Z-score: 2529.2 bits: 476.2 E(85289): 3.9e-134
Smith-Waterman score: 1952; 100.0% identity (100.0% similar) in 287 aa overlap (57-343:1-287)
30 40 50 60 70 80
pF1KE6 FLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFIKAPPRNYSM
::::::::::::::::::::::::::::::
XP_011 MEWSSRRSIFRMNGDKFRKFIKAPPRNYSM
10 20 30
90 100 110 120 130 140
pF1KE6 IVMFTALQPQRQCSVCRQANEEYQILANSWRYSSAFCNKLFFSMVDYDEGTDVFQQLNMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IVMFTALQPQRQCSVCRQANEEYQILANSWRYSSAFCNKLFFSMVDYDEGTDVFQQLNMN
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE6 SAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALAL
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE6 LVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQV
160 170 180 190 200 210
270 280 290 300 310 320
pF1KE6 SYIHGSSQAQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYIHGSSQAQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFF
220 230 240 250 260 270
330 340
pF1KE6 SFLLSIFRSKYHGYPYSFLIK
:::::::::::::::::
XP_011 SFLLSIFRSKYHGYPYSDLDFE
280 290
>>XP_016869350 (OMIM: 601385,611093) PREDICTED: tumor su (292 aa)
initn: 1952 init1: 1952 opt: 1952 Z-score: 2529.2 bits: 476.2 E(85289): 3.9e-134
Smith-Waterman score: 1952; 100.0% identity (100.0% similar) in 287 aa overlap (57-343:1-287)
30 40 50 60 70 80
pF1KE6 FLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFIKAPPRNYSM
::::::::::::::::::::::::::::::
XP_016 MEWSSRRSIFRMNGDKFRKFIKAPPRNYSM
10 20 30
90 100 110 120 130 140
pF1KE6 IVMFTALQPQRQCSVCRQANEEYQILANSWRYSSAFCNKLFFSMVDYDEGTDVFQQLNMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IVMFTALQPQRQCSVCRQANEEYQILANSWRYSSAFCNKLFFSMVDYDEGTDVFQQLNMN
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE6 SAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALAL
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE6 LVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQV
160 170 180 190 200 210
270 280 290 300 310 320
pF1KE6 SYIHGSSQAQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SYIHGSSQAQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFF
220 230 240 250 260 270
330 340
pF1KE6 SFLLSIFRSKYHGYPYSFLIK
:::::::::::::::::
XP_016 SFLLSIFRSKYHGYPYSDLDFE
280 290
>>XP_011542953 (OMIM: 601385,611093) PREDICTED: tumor su (303 aa)
initn: 1947 init1: 1947 opt: 1947 Z-score: 2522.5 bits: 475.0 E(85289): 9.1e-134
Smith-Waterman score: 1947; 100.0% identity (100.0% similar) in 286 aa overlap (57-342:1-286)
30 40 50 60 70 80
pF1KE6 FLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFIKAPPRNYSM
::::::::::::::::::::::::::::::
XP_011 MEWSSRRSIFRMNGDKFRKFIKAPPRNYSM
10 20 30
90 100 110 120 130 140
pF1KE6 IVMFTALQPQRQCSVCRQANEEYQILANSWRYSSAFCNKLFFSMVDYDEGTDVFQQLNMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IVMFTALQPQRQCSVCRQANEEYQILANSWRYSSAFCNKLFFSMVDYDEGTDVFQQLNMN
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE6 SAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALAL
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE6 LVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQV
160 170 180 190 200 210
270 280 290 300 310 320
pF1KE6 SYIHGSSQAQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYIHGSSQAQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFF
220 230 240 250 260 270
330 340
pF1KE6 SFLLSIFRSKYHGYPYSFLIK
::::::::::::::::
XP_011 SFLLSIFRSKYHGYPYREKSSDKNVYQKTDTWS
280 290 300
>>XP_016869349 (OMIM: 601385,611093) PREDICTED: tumor su (305 aa)
initn: 1947 init1: 1947 opt: 1947 Z-score: 2522.5 bits: 475.0 E(85289): 9.2e-134
Smith-Waterman score: 1947; 100.0% identity (100.0% similar) in 286 aa overlap (57-342:1-286)
30 40 50 60 70 80
pF1KE6 FLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFIKAPPRNYSM
::::::::::::::::::::::::::::::
XP_016 MEWSSRRSIFRMNGDKFRKFIKAPPRNYSM
10 20 30
90 100 110 120 130 140
pF1KE6 IVMFTALQPQRQCSVCRQANEEYQILANSWRYSSAFCNKLFFSMVDYDEGTDVFQQLNMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IVMFTALQPQRQCSVCRQANEEYQILANSWRYSSAFCNKLFFSMVDYDEGTDVFQQLNMN
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE6 SAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALAL
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE6 LVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQV
160 170 180 190 200 210
270 280 290 300 310 320
pF1KE6 SYIHGSSQAQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SYIHGSSQAQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFF
220 230 240 250 260 270
330 340
pF1KE6 SFLLSIFRSKYHGYPYSFLIK
::::::::::::::::
XP_016 SFLLSIFRSKYHGYPYRHAVVLTVKSSVWRKYIHP
280 290 300
>>XP_011542956 (OMIM: 601385,611093) PREDICTED: tumor su (258 aa)
initn: 1743 init1: 1743 opt: 1743 Z-score: 2259.2 bits: 426.1 E(85289): 4.2e-119
Smith-Waterman score: 1743; 100.0% identity (100.0% similar) in 256 aa overlap (57-312:1-256)
30 40 50 60 70 80
pF1KE6 FLLLLLLLCIQLGGGQKKKENLLAEKVEQLMEWSSRRSIFRMNGDKFRKFIKAPPRNYSM
::::::::::::::::::::::::::::::
XP_011 MEWSSRRSIFRMNGDKFRKFIKAPPRNYSM
10 20 30
90 100 110 120 130 140
pF1KE6 IVMFTALQPQRQCSVCRQANEEYQILANSWRYSSAFCNKLFFSMVDYDEGTDVFQQLNMN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IVMFTALQPQRQCSVCRQANEEYQILANSWRYSSAFCNKLFFSMVDYDEGTDVFQQLNMN
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE6 SAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SAPTFMHFPPKGRPKRADTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALAL
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE6 LVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVSLVGGLLYLRRNNLEFIYNKTGWAMVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQV
160 170 180 190 200 210
270 280 290 300 310 320
pF1KE6 SYIHGSSQAQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFF
::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SYIHGSSQAQFVAESHIILVLNAAITMGMVLLNEAATSKGDVGKRRTF
220 230 240 250
330 340
pF1KE6 SFLLSIFRSKYHGYPYSFLIK
>>NP_115497 (OMIM: 300715,300853) magnesium transporter (367 aa)
initn: 1633 init1: 1633 opt: 1643 Z-score: 2127.5 bits: 402.2 E(85289): 9.2e-112
Smith-Waterman score: 1643; 69.1% identity (93.8% similar) in 324 aa overlap (24-346:43-366)
10 20 30 40 50
pF1KE6 MGARGAPSRRRQAGRRLRYLPTGSFPFLLLLLLLC-IQLGGGQKKKENLLAEK
: ... ::..: . ...:.::: .:.::
NP_115 RPTLRPSRSKVSLIEGRGANMAARWRFWCVSVTMVVALLIVCDVPSASAQRKKEMVLSEK
20 30 40 50 60 70
60 70 80 90 100 110
pF1KE6 VEQLMEWSSRRSIFRMNGDKFRKFIKAPPRNYSMIVMFTALQPQRQCSVCRQANEEYQIL
: :::::...: ..::::::::...::::::::.:::::::: .::: ::.::.::.:::
NP_115 VSQLMEWTNKRPVIRMNGDKFRRLVKAPPRNYSVIVMFTALQLHRQCVVCKQADEEFQIL
80 90 100 110 120 130
120 130 140 150 160 170
pF1KE6 ANSWRYSSAFCNKLFFSMVDYDEGTDVFQQLNMNSAPTFMHFPPKGRPKRADTFDLQRIG
:::::::::: :..::.:::.:::.::::.:::::::::..:: ::.:::.::..:: :
NP_115 ANSWRYSSAFTNRIFFAMVDFDEGSDVFQMLNMNSAPTFINFPAKGKPKRGDTYELQVRG
140 150 160 170 180 190
180 190 200 210 220 230
pF1KE6 FAAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYLRRNNLEFIYNKTGWA
:.:::.:.::::::::.:::.:::::.: . :.::....:::.::::.:.::..::::::
NP_115 FSAEQIARWIADRTDVNIRVIRPPNYAGPLMLGLLLAVIGGLVYLRRSNMEFLFNKTGWA
200 210 220 230 240 250
240 250 260 270 280 290
pF1KE6 MVSLCIVFAMTSGQMWNHIRGPPYAHKNPHNGQVSYIHGSSQAQFVAESHIILVLNAAIT
...::.:.::::::::::::::::::::::.:.:.:::::::::::::.::.:..:...:
NP_115 FAALCFVLAMTSGQMWNHIRGPPYAHKNPHTGHVNYIHGSSQAQFVAETHIVLLFNGGVT
260 270 280 290 300 310
300 310 320 330 340
pF1KE6 MGMVLLNEAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPYSFLIK
.::::: ::::: :.:::.:.:..:.::::.:::..::::::::::::::::.
NP_115 LGMVLLCEAATSDMDIGKRKIMCVAGIGLVVLFFSWMLSIFRSKYHGYPYSFLMS
320 330 340 350 360
347 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 11:54:39 2016 done: Tue Nov 8 11:54:40 2016
Total Scan time: 7.240 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]