Result of FASTA (omim) for
pFN21AE6288
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE6288, 307 aa
1>>>pF1KE6288 307 - 307 aa - 307 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4168+/-0.000308; mu= 15.7070+/- 0.019
mean_var=76.5528+/-15.682, 0's: 0 Z-trim(117.1): 17 B-trim: 1395 in 1/52
Lambda= 0.146586
statistics sampled from 28803 (28819) to 28803 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.695), E-opt: 0.2 (0.338), width: 16
Scan time: 4.720
The best scores are: opt bits E(85289)
NP_945349 (OMIM: 609789) aquaporin-12A precursor [ ( 295) 1697 367.9 1.4e-101
NP_766627 (OMIM: 609914) aquaporin-11 [Homo sapien ( 271) 385 90.4 4.3e-18
XP_005273974 (OMIM: 609914) PREDICTED: aquaporin-1 ( 232) 239 59.5 7.4e-09
NP_001160 (OMIM: 603750) aquaporin-8 [Homo sapiens ( 261) 150 40.7 0.0038
XP_011544124 (OMIM: 603750) PREDICTED: aquaporin-8 ( 262) 150 40.7 0.0038
>>NP_945349 (OMIM: 609789) aquaporin-12A precursor [Homo (295 aa)
initn: 1695 init1: 1695 opt: 1697 Z-score: 1944.9 bits: 367.9 E(85289): 1.4e-101
Smith-Waterman score: 1912; 95.1% identity (95.8% similar) in 307 aa overlap (1-307:1-295)
10 20 30 40 50 60
pF1KE6 MAGLNVSLSFFFATFTLCEAARRASKALLPVGAYEVFAREAVGAVQLGACFLEMRTLVEL
:::::::::::::::.::::::::::::::::::::::::: :::::::
NP_945 MAGLNVSLSFFFATFALCEAARRASKALLPVGAYEVFAREA------------MRTLVEL
10 20 30 40
70 80 90 100 110 120
pF1KE6 GPWAGDFGPDLLLTLLFLLFLAHGVTLDGASANPTVSLQEFLMAEESLPGTLLKLAAQGL
:::::::::::::::::::::::::::::::::::::::::::::.::::::::::::::
NP_945 GPWAGDFGPDLLLTLLFLLFLAHGVTLDGASANPTVSLQEFLMAEQSLPGTLLKLAAQGL
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE6 GMQAACTLTRLCWAWELSDLHLLQSLMAQSCSSALRTSVPHGALVEAACAFCFHLTLLHL
:::::::: :::::::::::::::::::::::::::::::::::::::::::::::::::
NP_945 GMQAACTLMRLCWAWELSDLHLLQSLMAQSCSSALRTSVPHGALVEAACAFCFHLTLLHL
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE6 RHSPPAYSGPAVALLVTVTAYTAGPFTSAFFNPALAASVTFACSGHTLLEYVQVYWLGPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_945 RHSPPAYSGPAVALLVTVTAYTAGPFTSAFFNPALAASVTFACSGHTLLEYVQVYWLGPL
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE6 TGMVLAVLLHQGRLPHLFQRNLFYGQKNKYRAPRGKPAPASGDTQTPAKGSSVREPGRSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_945 TGMVLAVLLHQGRLPHLFQRNLFYGQKNKYRAPRGKPAPASGDTQTPAKGSSVREPGRSG
230 240 250 260 270 280
pF1KE6 VEGPHSS
:::::::
NP_945 VEGPHSS
290
>>NP_766627 (OMIM: 609914) aquaporin-11 [Homo sapiens] (271 aa)
initn: 360 init1: 224 opt: 385 Z-score: 445.9 bits: 90.4 E(85289): 4.3e-18
Smith-Waterman score: 385; 30.6% identity (62.0% similar) in 255 aa overlap (7-257:17-261)
10 20 30 40 50
pF1KE6 MAGLNVSLSFFFATFTLCEAARRASKALLPVGAYEVFAREAVGAVQLGAC
::...... : :: ... : . ..:. : ... :: :
NP_766 MSPLLGLRSELQDTCTSLGLMLSVVLLMGLARVVARQQLHRPVAHAFVLEFLATFQLCCC
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 FLEMRTLVELGPWAGDFGPDLLLTLLFLLFLAHGVTLDGASANPTVSLQEFLMAEESLPG
:.. : : : : :::.... :.::.:: :.:.:: ....... :
NP_766 THELQLLSEQHPAH----PTWTLTLVYFFSLVHGLTLVGTSSNPCGVMMQMMLGGMSPET
70 80 90 100 110
120 130 140 150 160
pF1KE6 TLLKLAAQGLGMQAACTLTRLC----WAWELSDLHLLQSLMAQSCSSALRTSVPHGALVE
..: :: .. : :. : : :. :.. :. . .: :.. .:... .....:
NP_766 GAVRLLAQLVS--ALCS--RYCTSALWSLGLTQYHVSERSFA--CKNPIRVDLLKAVITE
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE6 AACAFCFHLTLLHLRHSPPAYSGPAVALLVTVTAYTAGPFTSAFFNPALAASVTFACSGH
:.:.: :: .:::... .: :.: .:..: .:.: :::::: :. : : .
NP_766 AVCSFLFHSALLHFQEVRTKLRIHLLAALITFLVYAGGSLTGAVFNPALALSLHFMCFDE
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE6 TLLEYVQVYWLGPLTGMVLAVLLHQGRLPHLFQRNLFYGQKNKYRAPRGKPAPASGDTQT
.. .. ::::.: :..: .:. . :: :
NP_766 AFPQFFIVYWLAPSLGILLMILMFSFFLPWLHNNHTINKKE
240 250 260 270
290 300
pF1KE6 PAKGSSVREPGRSGVEGPHSS
>>XP_005273974 (OMIM: 609914) PREDICTED: aquaporin-11 is (232 aa)
initn: 182 init1: 98 opt: 239 Z-score: 279.9 bits: 59.5 E(85289): 7.4e-09
Smith-Waterman score: 239; 28.1% identity (58.5% similar) in 217 aa overlap (7-215:17-222)
10 20 30 40 50
pF1KE6 MAGLNVSLSFFFATFTLCEAARRASKALLPVGAYEVFAREAVGAVQLGAC
::...... : :: ... : . ..:. : ... :: :
XP_005 MSPLLGLRSELQDTCTSLGLMLSVVLLMGLARVVARQQLHRPVAHAFVLEFLATFQLCCC
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE6 FLEMRTLVELGPWAGDFGPDLLLTLLFLLFLAHGVTLDGASANPTVSLQEFLMAEESLPG
:.. : : : : :::.... :.::.:: :.:.:: ....... :
XP_005 THELQLLSEQHPAH----PTWTLTLVYFFSLVHGLTLVGTSSNPCGVMMQMMLGGMSPET
70 80 90 100 110
120 130 140 150 160
pF1KE6 TLLKLAAQGLGMQAACTLTRLC----WAWELSDLHLLQSLMAQSCSSALRTSVPHGALVE
..: :: .. : :. : : :. :.. :. . .: :.. .:... .....:
XP_005 GAVRLLAQLVS--ALCS--RYCTSALWSLGLTQYHVSERSFA--CKNPIRVDLLKAVITE
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE6 AACAFCFHLTLLHLRHSPPAYSGPAVALLVTVTAYTAGPFTS----AFFNPALAASVTFA
:.:.: :: .:::... .: :.: .: :: . .:: : :
XP_005 AVCSFLFHSALLHFQEVRTKLRIHLLAALITFLVY-AGILLMILMFSFFLPWLHNNHTIN
180 190 200 210 220
230 240 250 260 270 280
pF1KE6 CSGHTLLEYVQVYWLGPLTGMVLAVLLHQGRLPHLFQRNLFYGQKNKYRAPRGKPAPASG
XP_005 KKE
230
>>NP_001160 (OMIM: 603750) aquaporin-8 [Homo sapiens] (261 aa)
initn: 140 init1: 63 opt: 150 Z-score: 177.5 bits: 40.7 E(85289): 0.0038
Smith-Waterman score: 150; 25.0% identity (54.0% similar) in 248 aa overlap (17-249:7-245)
10 20 30 40 50
pF1KE6 MAGLNVSLSFFFATFTLCEAARRASKALLP-VGA------YEVFAREAVGAVQLGACFLE
.:: .:: : ::. :: :.. . . .: :.
NP_001 MSGEIAMCEPEFGNDKAREPSVGGRWRVSWYERFVQPCLVELLGSALFIF
10 20 30 40 50
60 70 80 90 100 110
pF1KE6 MRTL--VELGPWAGDFGPDLLLTLLFLLFLAHGVTLDGASANPTVSLQEFLMAEESLPGT
. : .: : .: . : : : . : .: ...:. ::.::: .:.. .:
NP_001 IGCLSVIENGTDTGLLQPALAHGLALGLVIATLGNISGGHFNPAVSLAAMLIGGLNLVML
60 70 80 90 100 110
120 130 140 150 160
pF1KE6 LLKLAAQGLGMQAACTLTRLCWA----WELSDLHLLQSLMAQSCSSALRTSVPHGALVEA
: ..: :: . . .:.. :. : .. . ..:: . . .:.
NP_001 LPYWVSQLLGGMLGAALAKAVSPEERFWNASGAAFVTVQEQGQVAGALVAEIILTTLL--
120 130 140 150 160
170 180 190 200 210 220
pF1KE6 ACAFCFHLTLLHLRHSPPAYSGP-AVALLVTVTAYTAGPFTSAFFNPALAASVTFACSGH
: : : . .. . . : .: .... ::: ..:: ... .::: : . . . ..:
NP_001 ALAVC--MGAINEKTKGPL--APFSIGFAVTVDILAGGPVSGGCMNPARAFGPAVV-ANH
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE6 TLLEYVQVYWLGPL-TGMVLAVLLHQGRLPHLFQRNLFYGQKNKYRAPRGKPAPASGDTQ
.. .:::::: .:.....:.
NP_001 --WNFHWIYWLGPLLAGLLVGLLIRCFIGDGKTRLILKAR
230 240 250 260
>>XP_011544124 (OMIM: 603750) PREDICTED: aquaporin-8 iso (262 aa)
initn: 140 init1: 63 opt: 150 Z-score: 177.5 bits: 40.7 E(85289): 0.0038
Smith-Waterman score: 150; 25.0% identity (54.0% similar) in 248 aa overlap (17-249:8-246)
10 20 30 40 50
pF1KE6 MAGLNVSLSFFFATFTLCEAARRASKALLP-VGA------YEVFAREAVGAVQLGACFLE
.:: .:: : ::. :: :.. . . .: :.
XP_011 MSGEQIAMCEPEFGNDKAREPSVGGRWRVSWYERFVQPCLVELLGSALFIF
10 20 30 40 50
60 70 80 90 100 110
pF1KE6 MRTL--VELGPWAGDFGPDLLLTLLFLLFLAHGVTLDGASANPTVSLQEFLMAEESLPGT
. : .: : .: . : : : . : .: ...:. ::.::: .:.. .:
XP_011 IGCLSVIENGTDTGLLQPALAHGLALGLVIATLGNISGGHFNPAVSLAAMLIGGLNLVML
60 70 80 90 100 110
120 130 140 150 160
pF1KE6 LLKLAAQGLGMQAACTLTRLCWA----WELSDLHLLQSLMAQSCSSALRTSVPHGALVEA
: ..: :: . . .:.. :. : .. . ..:: . . .:.
XP_011 LPYWVSQLLGGMLGAALAKAVSPEERFWNASGAAFVTVQEQGQVAGALVAEIILTTLL--
120 130 140 150 160
170 180 190 200 210 220
pF1KE6 ACAFCFHLTLLHLRHSPPAYSGP-AVALLVTVTAYTAGPFTSAFFNPALAASVTFACSGH
: : : . .. . . : .: .... ::: ..:: ... .::: : . . . ..:
XP_011 ALAVC--MGAINEKTKGPL--APFSIGFAVTVDILAGGPVSGGCMNPARAFGPAVV-ANH
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE6 TLLEYVQVYWLGPL-TGMVLAVLLHQGRLPHLFQRNLFYGQKNKYRAPRGKPAPASGDTQ
.. .:::::: .:.....:.
XP_011 --WNFHWIYWLGPLLAGLLVGLLIRCFIGDGKTRLILKAR
230 240 250 260
307 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 11:48:48 2016 done: Tue Nov 8 11:48:48 2016
Total Scan time: 4.720 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]